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Ganjali R, Sabbagh MG, Nazemiyan F, et al.Immunotargets Ther. 2019;8:53–62. The authors have advised that Table 2 on page 57 isincorrect. The correct table is shown below. The authors apologize for this error. Read the original article

Raheleh Ganjali,1 Mahin Ghorban Sabbagh,2,3 Fatemeh Nazemiyan,2,4 Fereshteh Mamdouhi,2,3 Shapour Badiee Aval,5 Zhila Taherzadeh,6 Fatemeh Heshmati Nabavi,7 Reza Golmakani,8 Fariba Tohidinezhad,1 Saeid Eslami1,9,10 1Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 2Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 3Department of Nephrology, Montaseriyeh Organ Transplantation Hospital, Mashhad University of Medical Sciences, Mashhad, Iran; 4Department of Nephrology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran; 5Complementary Medicine Research Center, Faculty of Traditional Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 6Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 7School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran; 8Department of Emergency Medicine, Doctor Shariati Hospital, Mashhad University of Medical Sciences, Mashhad, Iran; 9Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 10Department of Medical Informatics, University of Amsterdam, Amsterdam, The NetherlandsCorrespondence: Saeid EslamiDepartment of Medical Informatics, Mashhad University of Medical Sciences, Azadi Street, Mashhad, IranTel +98 513 800 2429Fax +98 513 800 2445Email Eslamis@mums.ac.irBackground: Medication non-adherence is the major risk factor for rejection episodes. The aim of this study was to determine the risk factors associated with adherence to immunosuppressive regimen and its barriers among kidney transplant (KT) recipients.Methods: A cross-sectional study was performed in two outpatient post-transplant clinics in Mashhad, northeast of Iran. All patients who attended the clinics from August to October 2017 were included. Patients’s knowledge, adherence to immunosuppressive regimen, and quality of life were measured using the Kidney Transplant Understanding Tool, Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS), and SF-12V2 questionnaire, respectively. The barriers in adhering immunosuppressive regimen were investigated by Immunosuppressive Therapy Barriers Scale. Logistic regression was used to screen the significant risk factors of medication non-adherence.Results: In this study, 244 KT recipients were included with a mean age of 39.6±12.5 years. Based on the BAASIS score, 111 (45.5%) patients were adherent to immunosuppressive regimen. Female patients were more likely to be adherent (OR=0.48, p

Raheleh Ganjali,1 Farnaz Khoshrounejad,1 Mohammad Reza Mazaheri Habibi,2 Zhila Taherzadeh,3 Reza Golmakani,4 Sayyed Mostafa Mostafavi,1 Saeid Eslami1,5,6 1Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 2Department of Health Information Technology, Varastegan Institute for Medical Sciences, Mashhad, Iran; 3Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 4Department of Emergency Medicine, Doctor Shariati Hospital, Mashhad University of Medical Sciences, Mashhad, Iran; 5Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 6Department of Medical Informatics, University of Amsterdam, Amsterdam, the NetherlandsCorrespondence: Saeid EslamiDepartment of Medical Informatics, Mashhad University of Medical Sciences, Azadi Street, Mashhad, IranTel +98 513 800 2429Fax +98 513 800 2445Email Eslamis@mums.ac.irIntroduction: Adolescent and young adult periods are characterized by increased risk-taking, impulsive behavior, and nonadherence issues, which makes it equally challenging for patients and their health care professionals. Health information technology (IT) has the potential to empower patients.Objective: Determine the effects and features of IT-based interventions for self-management of adolescents and young adults in kidney transplant recipients.Materials and Methods: A comprehensive survey was done on Medline and Scopus in September 2018. Eligible studies included randomized controlled trials (RCTs) and quasi-experimental studies focused on automated IT-based interventions. Studies contained information about adolescent and young adult kidney transplant recipients aged under 25, all published in English. The articles were combined with each other based on the classification of outcomes, the type of interventions, and their impact. The studies were categorized based on the impact of interventions as positive and statistically significant, with no effect, or a combined effect (both positive significance and without effect).Results: In this review, of a total of 2,242 retrieved articles, collected from Scopus and PubMed databases, 5 studies met the full-text inclusion criteria. Interventions were performed using computerized systems (3 studies), smartphone application/personal digital ass (PDA) (1 study), and multiple components (1 study). These studies evaluated 15 outcomes, including 7 care process and 8 clinical outcomes. In 6 of 15 outcomes (40%), interventions had a statistically significant positive effect.Conclusion: IT-based interventions such as mobile health/personal digital assistant(PDA), computer systems and multi-component have the potential to improve self-management in adolescents and young adult kidney transplant recipients (care process outcomes). It is recommended to conduct complementary research to examine the effect of IT-based self-management interventions on clinical outcomes in kidney transplant recipients.Keywords: adolescent, young adult, information technology, self-management

The aim of the paper is to investigate the association between physicians' adherence to a pharmacotherapy guideline and continuity of care for patients with depressive and/or anxiety disorders in a collaborative care program. This retrospective observational study was conducted using medical records of subjects suffering from depression and/or anxiety disorder visited by 26 general practitioners (GP) working with Community Mental Health Center (CMHC), who run a collaborative care program in Tehran, Iran. All patients were visited by a general practitioner in private offices from November 2010 to May 2013. A scoring system was utilized to assess physicians' adherence to the pharmacotherapy guideline using medical records. Patients' continuity of care was calculated based on the number of days of being in the collaborative care program. To investigate the association between physicians' adherence to the guideline and the patients' continuity of care, univariate logistic regression analysis, multiple logistic regression analysis and parametric survival analysis were performed using Stata version 11. A total of 3,338 patients were studied. Their mean age was 37 years and 81.6% were female. Being treated by a particular GP was an important factor in patients with depressive and/or anxiety diagnosis as well as having both diagnoses. Furthermore, higher score of adherence to the guideline was associated with less continuity of care in depressive patients. Being treated by certain GPs is an effective way of retention of patients in the treatment. The results demonstrate that patients with guideline-based pharmacotherapy need to be told about continuity of care in community mental health program