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269 results on '"Taguchi, Takahide"'

5. Acoustic Characteristics of Ataxic Speech in Japanese Patients with Spinocerebellar Degeneration (SCD)

Author

Ikui, Yukiko, Tsukuda, Mamoru, Kuroiwa, Yoshiyuki, Koyano, Shigeru, Hirose, Hajime, and Taguchi, Takahide

Abstract

Background: In English- and German-speaking countries, ataxic speech is often described as showing scanning based on acoustic impressions. Although the term "scanning" is generally considered to represent abnormal speech features including prosodic excess or insufficiency, any precise acoustic analysis of ataxic speech has not been performed in Japanese-speaking patients. This raises the question of what is the most dominant acoustic characteristic of ataxic speech in Japanese subjects, particularly related to the perceptual impression of "scanning". Aims: The study was designed to investigate the nature of speech characteristics of Japanese ataxic subjects, particularly "scanning", by means of acoustic analysis. Methods & Procedures: The study comprised 20 Japanese cases with spinocerebellar degeneration diagnosed to have a perceptual impression of scanning by neurologists (ataxic group) and 20 age-matched normal healthy subjects (control group). Recordings of speech samples of Japanese test sentences were obtained from each subject. The recorded and digitized acoustic samples were analysed using "Acoustic Core-8" (Arcadia Inc.). Outcomes & Results: Sentence duration was significantly longer in the ataxic group as compared with the control group, indicating that the speaking rate was slower in the ataxic subjects. Segment duration remained consistent in both vowels and consonants in the control group as compared with the ataxic group. In particular, the duration of vowel segments, i.e. the nucleus of Japanese mora, was significantly invariable in the control group regardless of differences between subjects as well as in segments compared with the ataxic group. In addition, the duration of phonemically long Japanese vowels was significantly shorter in the ataxic group. Conclusions & Implications: The results indicate that the perceptual impression of "scanning" in Japanese ataxic cases derives mainly from the breakdown of isochrony in terms of difficulty in keeping the length of vowel segments of Japanese invariable during speech production. In addition, the tendency toward irregular shortening of the length of phonemically long Japanese vowels is thought to reinforce the impression of "scanning" in ataxic speech in Japanese cases. (Contains 2 tables and 6 figures.)

Published
2012
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14. Randomized controlled phase II comparison study of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil versus CCRT with cisplatin, 5-fluorouracil, methotrexate and leucovorin in patients with locally advanced squamous cell carcinoma of the head and neck

Author

Tsukuda, Mamoru, Ishitoya, Junichi, Matsuda, Hideki, Horiuchi, Choichi, Taguchi, Takahide, Takahashi, Masahiro, Nishimura, Goshi, Kawakami, Mariko, Watanabe, Makiko, Niho, Tatsuo, Kawano, Toshiro, Ikeda, Yoichi, Sakuma, Yasunori, Shiono, Osamu, and Komatsu, Masanori

Published
2010
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16. Analysis of feasibility and toxicity of concurrent chemoradiotherapy with S-1 for locally advanced squamous cell carcinoma of the head and neck in elderly cases and/or cases with comorbidity

Author

Tsukuda, Mamoru, Ishitoya, Junichi, Mikami, Yasukazu, Matsuda, Hideki, Horiuchi, Choichi, Taguchi, Takahide, Satake, Kenichi, Kawano, Toshiro, Takahashi, Masahiro, Nishimura, Goshi, Kawakami, Mariko, Sakuma, Yasunori, Watanabe, Makiko, Shiono, Osamu, Komatsu, Masanori, and Yamashita, Yukiko

Published
2009
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32. Symmetric Lipomatosis Arising in the Tongue Presenting as Macroglossia and Articulatory Disorder

Author

Kudoh, Masanori, Omura, Ken, Satsukawa, Arata, Matsumoto, Koshi, Taguchi, Takahide, Harada, Hiroyuki, and Ishii, Yoshimasa

Subjects
Article Subject
Abstract

Symmetric lipomatosis is definitively characterized by symmetric, tumorous lipomatous proliferation of adipose tissue that often develops in the head and neck, shoulders, and upper trunk. However, in the oral region, symmetric lipomatosis of the tongue (SLT) is an extremely rare condition related to generalized lipidosis that is often caused by chronic alcoholism. It is characterized by multiple symmetric lipomatous nodules and diffuse bilateral swelling located within the tongue. We report an extremely rare case of SLT arising in an 80-year-old man with a long history of alcoholic liver cirrhosis. He exhibited multiple soft nodular protrusions on the bilateral margin of the tongue presenting as macroglossia for years. Although MR imaging showed multiple fatty masses on both sides of the tongue, there was no elevated tumor mass on the bilateral margin. The patient underwent bilateral partial glossectomy under general anesthesia. Histopathologically, the resected tumor exhibited diffuse infiltration with mature adipose tissue lacking a fibrous capsule. Due to the lipidosis and the unusual presentation of multiple lesions, the lesion was ultimately diagnosed as SLT. At present, after surgery, the patient wears a full-denture and is in excellent condition, with no sign of recurrence, improved QOL, and recovery of masticatory, articulatory, and speech intelligibility functions.

Published
2016
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33. Surgery-based versus radiation-based treatment strategy for a high metabolic volume laryngeal cancer

Author

Yabuki, Kenichiro, primary, Sano, Daisuke, additional, Shiono, Osamu, additional, Arai, Yasuhiro, additional, Chiba, Yoshihiro, additional, Tanabe, Teruhiko, additional, Nishimura, Goshi, additional, Takahashi, Masahiro, additional, Taguchi, Takahide, additional, Kaneta, Tomohiro, additional, Hata, Masaharu, additional, and Oridate, Nobuhiko, additional

Published
2016
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34. Prognostic significance of metabolic tumor volume in patients with piriform sinus carcinoma treated by radiotherapy with or without concurrent chemotherapy

Author

Yabuki, Kenichiro, primary, Sano, Daisuke, additional, Shiono, Osamu, additional, Arai, Yasuhiro, additional, Takahashi, Hideaki, additional, Chiba, Yoshihiro, additional, Tanabe, Teruhiko, additional, Nishimura, Goshi, additional, Takahashi, Masahiro, additional, Taguchi, Takahide, additional, Kaneta, Tomohiro, additional, Hata, Masaharu, additional, and Oridate, Nobuhiko, additional

Published
2016
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35. Tow cases of malleus ankylosis

Author

Sakuma, Naoko, primary, Takahashi, Masahiro, additional, Inoue, Maki, additional, Yamamoto, Takae, additional, Arai, Yasuhiro, additional, Taguchi, Takahide, additional, and Oridate, Nobuhiko, additional

Published
2016
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37. Imaging strategy for response evaluation to chemoradiotherapy of the nodal disease in patients with head and neck squamous cell carcinoma

Author

Nishimura, Goshi, primary, Yabuki, Kenichiro, additional, Hata, Masaharu, additional, Komatsu, Masanori, additional, Taguchi, Takahide, additional, Takahashi, Masahiro, additional, Shiono, Osamu, additional, Sano, Daisuke, additional, Arai, Yasuhiro, additional, Takahashi, Hideaki, additional, Chiba, Yoshihiro, additional, and Oridate, Nobuhiko, additional

Published
2015
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38. Adjuvant chemotherapy with S-1 after curative chemoradiotherapy in patients with locoregionally advanced squamous cell carcinoma of the head and neck: Reanalysis of the ACTS-HNC study.

Author

Kubota, Akira, Nakatani, Eiji, Tsukahara, Kiyoaki, Hasegawa, Yasuhisa, Takemura, Hideki, Terada, Tomonori, Taguchi, Takahide, Nagahara, Kunihiko, Nakatani, Hiroaki, Yoshino, Kunitoshi, Higaki, Yuichiro, Iwae, Shigemichi, Beppu, Takeshi, Hanamure, Yutaka, Tomita, Kichinobu, Kohno, Naoyuki, Kawabata, Kazuyoshi, Teramukai, Satoshi, Fujii, Masato, and null, null

Subjects
HEAD & neck cancer treatment, CANCER treatment, SQUAMOUS cell carcinoma, ADJUVANT treatment of cancer, CANCER chemotherapy, CLINICAL trials
Abstract

Background: Chemoradiotherapy (CRT) has improved organ preservation or overall survival (OS) of locoregionally advanced head and neck squamous cell cancer (LAHNSCC), but in clinical trials of conventional CRT, increasing CRT intensity has not been shown to improve OS. In the Adjuvant ChemoTherapy with S-1 after curative treatment in patients with Head and Neck Cancer (ACTS-HNC) phase III study, OS of curative locoregional treatments improved more with adjuvant chemotherapy with S-1 (tegafur gimeracil oteracil potassium) than with tegafur/uracil (UFT). ACTS HNC study showed the significant efficacy of S-1 after curative radiotherapy in sub-analysis. We explored the efficacy of S-1 after curative CRT in a subset of patients from the ACTS-HNC study. Methods: Patients with stage III, IVA, or IVB LAHNSCC were enrolled in this study to evaluate the efficacy of S-1 compared with UFT as adjuvant chemotherapy after curative CRT in the ACTS-HNC study. Patients received S-1 at 80–120 mg/day in two divided doses for 2 weeks, followed by a 1-week rest, or UFT 300 or 400 mg/day in two or three divided doses daily, for 1 year. The endpoints were OS, disease-free survival, locoregional relapse-free survival, distant metastasis-free survival (DMFS), and post-locoregional relapse survival. Results: One hundred eighty patients (S-1, n = 87; UFT, n = 93) were included in this study. Clinical characteristics of the S-1 and UFT arms were similar. S-1 after CRT significantly improved OS (hazard ratio [HR], 0.46; 95% confidence interval [CI], 0.22–0.93) and DMFS (HR, 0.50; 95% CI, 0.26–0.97) compared with UFT. Conclusion: As adjuvant chemotherapy, S-1 demonstrated better efficacy for OS and DMFS than UFT in patients with LAHNSCC after curative CRT and may be considered a treatment option following curative CRT. For this study was not preplanned in the ACTS-HNC study, the results is hypothesis generating but not definitive. [ABSTRACT FROM AUTHOR]

Published
2018
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39. Predictive markers, including total lesion glycolysis, for the response of lymph node(s) metastasis from head and neck squamous cell carcinoma treated by chemoradiotherapy

Author

Nishimura, Goshi, primary, Komatsu, Masanori, additional, Hata, Masaharu, additional, Yabuki, Kenichiro, additional, Taguchi, Takahide, additional, Takahashi, Masahiro, additional, Shiono, Osamu, additional, Sano, Daisuke, additional, Arai, Yasuhiro, additional, Takahashi, Hideaki, additional, Chiba, Yoshihiro, additional, and Oridate, Nobuhiko, additional

Published
2015
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44. Surgery-based versus radiation-based treatment strategy for a high metabolic volume laryngeal cancer.

Author

Yabuki, Kenichiro, Sano, Daisuke, Shiono, Osamu, Arai, Yasuhiro, Chiba, Yoshihiro, Tanabe, Teruhiko, Nishimura, Goshi, Takahashi, Masahiro, Taguchi, Takahide, Kaneta, Tomohiro, Hata, Masaharu, and Oridate, Nobuhiko

Abstract

Objective/hypothesis: We previously reported that the metabolic tumor volume (MTV) of a primary tumor was an independent prognostic factor for survival in laryngeal carcinoma treated by radiotherapy (RT)-based protocol. The purpose of this study was to evaluate the difference in survival outcomes between surgery-based and RT-based treatment in patients with a MTV laryngeal cancer.Study Design: An individual retrospective cohort study.Methods: We reviewed the records of 63 patients with laryngeal cancer showing a primary tumor with a high MTV value (≥ 4.9 mL). The patients were separated into two groups by primary treatment strategy: 22 patients were included in the surgery group, and 41 patients were included in the RT group. Clinical factors and treatment modalities were analyzed for their association with survival.Results: Multivariate analysis, including age, sex, subsite, T classification, nodal metastasis, and treatment modality, showed that the subsite (hazard ratio [HR] 2.55, P = 0.043) and treatment modality (HR 3.98, P = 0.019) were independent predictors for survival. The Kaplan-Meier curves for 2-year relapse-free survival rates and overall survival rates for patients in the surgery and RT groups were 74.2% versus 38.8% (P = 0.025) and 80.1% versus 66.7% (P = 0.078).Conclusions: Patients with a high metabolic volume laryngeal cancer treated by a surgery-based protocol showed better relapse-free survival and overall survival than did those undergoing RT-based treatment. Pretreatment MTV assessment could be useful in planning the treatment strategy for patients with a laryngeal cancer.Level Of Evidence: 2b. Laryngoscope, 127:862-867, 2017. [ABSTRACT FROM AUTHOR]

Published
2017
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47. The Accuracy of Evaluating the Response of Metastatic Lymph Nodes after Concurrent Chemoradiotherapy in Patients with Head and Neck Squamous Cell Carcinoma

Author

Nishimura, Goshi, primary, Komatsu, Masanori, additional, Taguchi, Takahide, additional, Takahashi, Masahiro, additional, Sano, Daisuke, additional, Sakuma, Naoko, additional, Arai, Yasuhiro, additional, Takahashi, Hideaki, additional, Tanaka, Yasuko, additional, Sawakuma, Kae, additional, and Oridate, Nobuhiko, additional

Published
2014
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