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The role of serotonin in human behaviour is informed by approaches which allow in vivo modification of synaptic serotonin. However, characterising the effects of increased serotonin signalling in human models of behaviour is challenging given the limitations of available experimental probes, notably selective serotonin reuptake inhibitors. Here we use a now-accessible approach to directly increase synaptic serotonin in humans (a selective serotonin releasing agent) and examine its influence on domains of behaviour historically considered core functions of serotonin. Computational techniques, including reinforcement learning and drift diffusion modelling, explain participant behaviour at baseline and after week-long intervention. Reinforcement learning models reveal that increasing synaptic serotonin reduces sensitivity for outcomes in aversive contexts. Furthermore, increasing synaptic serotonin enhances behavioural inhibition, and shifts bias towards impulse control during exposure to aversive emotional probes. These effects are seen in the context of overall improvements in memory for neutral verbal information. Our findings highlight the direct effects of increasing synaptic serotonin on human behaviour, underlining its role in guiding decision-making within aversive and more neutral contexts, and offering implications for longstanding theories of central serotonin function., (© 2024. The Author(s).)

Background: Only few studies have been conducted on leg length discrepancy (LLD) in patients with hip osteoarthritis (OA). This study aimed to examine the relationship between perceived LLD (pLLD) and structural LLD (sLLD) in patients with advanced OA and to determine the factors influencing both LLDs. This retrospective study aimed to answer the following questions: (1) are older adults less likely to perceive LLD than younger adults? (2) is there a relationship between pLLD and sLLD? and (3) is pLLD associated with patient satisfaction?, Hypothesis: We hypothesized that older adults are less likely to perceive LLD than younger adults., Patients and Methods: We recruited 125 patients (102 women and 23 men) with hip OA associated with developmental dysplasia of the hip defined as grade 3 or higher according to the Tönnis classification and excluding contralateral grade 2 or higher. The mean age of the patients was 65.2±11.2 (36-85) years. Before surgery, 2-mm and 5-mm thick plates were placed on the floor on the plantar surface of the short leg to measure pLLD. Preoperative computed tomography (CT) was performed and sLLDs were measured using the 3D planning software ZedHip. The following associated factors were evaluated: age, height, weight, body mass index (BMI), adduction and abduction range of motion (ROM) of the affected hip joint, Crowe classification, standing pelvic inclination in the coronal plane, Cobb angle and Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ)., Results: The absolute difference between pLLD and sLLD was modestly positively correlated with age (R=0.206; p<0.05) indicating older patients were less prone to perceive LLD. A strong positive correlation was found between pLLD (4.8±7.3mm; range: -37 to 28mm) and sLLD (6.4±7.0mm; range: -29.9 to 23.7mm) (R=0.714, p<0.05). The greater the pLLD, the smaller the hip abduction ROM (24.8±11.6°; range: 0 to 45°) tended to be, while the greater the sLLD, the smaller the hip abduction and adduction ROM (10.3±5.7°; range: 0 to 25°) tended to be (R= -0.259 and R= -0.297, respectively; p<0.05) The clinical significance of this finding is that pLLD may be improved if hip ROM training is performed before surgery. pLLD was significantly smaller in the group without pelvic inclination (8.0±14.1mm; range: -37 to 22mm) than in the group with pelvic inclination to the affected side (6.9±7.5mm; range: -12 to 28mm) and in the group with no inclination to the affected side (7.3±7.6mm; range: -8 to 25mm) (p<0.05) The clinical significance of this finding is that improving pelvic inclination with hip ROM training or muscle stretching may also reduce pLLD. No significant differences were noted between pLLD and JHEQ total scores or subgroups., Discussion: Older patients had less pLLD. Preoperative pLLD was strongly correlated with sLLD but not with patient satisfaction. These results may be useful for conservative treatment of OA, preoperative planning and intraoperative leg length correction., Level of Evidence: IV; case control study., (Copyright © 2023 Elsevier Masson SAS. All rights reserved.)

Impaired cognition is often overlooked in the clinical management of depression, despite its association with poor psychosocial functioning and reduced clinical engagement. There is an outstanding need for new treatments to address this unmet clinical need, highlighted by our consultations with individuals with lived experience of depression. Here we consider the evidence to support different pharmacological approaches for the treatment of impaired cognition in individuals with depression, including treatments that influence primary neurotransmission directly as well as novel targets such as neurosteroid modulation. We also consider potential methodological challenges in establishing a strong evidence base in this area, including the need to disentangle direct effects of treatment on cognition from more generalised symptomatic improvement and the identification of sensitive, reliable and objective measures of cognition., (© 2022. The Author(s).)

Creativity is a valuable commodity. Research has revealed some identifying characteristics of creative people and some of the emotional states that can bring out the most creativity in all of us. It has also been shown that the long-term experience of different cultures and lifestyles that is the result of travel and immigration can also enhance creativity. However, the role of one-off, extreme, or unusual experiences on creativity has not been directly observed before. In part, that may be because, by their very nature, such experiences are very difficult to bring into the laboratory. Here, we brought the tools and empirical methods of the laboratory into the wild, measuring the psychological effects of a unique multisensory experience: an underwater nightclub. We showed - with fully randomized and experimentally controlled conditions - that such an experience boosted measures of divergent thinking in participants. This demonstrates that one element of creativity can be directly enhanced by unusual situations, and that experimental tools of psychology can be used to investigate a range of consumer experiences., Competing Interests: The underwater experience described in the MS was part of an experiential marketing event for Desperados, a brand sold by Heineken, who funded the event. One author was hired as a consultant to design and administer an experiment investigating the psychological consequences of diversifying experiences. Heineken played no role in designing the experiment or analyzing data., (Copyright © 2022 Richardson, Tagomori and Devlin.)

Background: Patients with developmental dysplasia of the hip (DDH) are known to have abnormal pelvic morphologies; however, rotation of innominate bone features remains unclear. Thus, we investigated innominate bone rotation in patients with DDH by measuring the associated angles and distances using three-dimensional (3D) computed tomography., Methods: We defined four straight lines in pelvic 3D models: from the anterior superior iliac spine to the posterior superior iliac spine, from the anterior inferior iliac spine to the posterior inferior iliac spine, from the pubic tubercle to the ischial spine, and from the pubic tubercle to the ischial tuberosity. Similarly, we measured the angles formed by these lines using the vertical axis of the anterior pelvic plane on the horizontal plane and the horizontal axis on the sagittal plane. Additionally, we measured the distances between the femoral head centers and the acetabular centers in the coronal plane., Results: The difference in internal rotation angle between the superior and inferior parts of the iliac bone was significantly lower, by approximately 1.7°, in the DDH group than in the control group ( p = 0.007); the difference between the inferior and superior parts of the ischiopubic bone was significantly higher, by approximately 1.5°, in the DDH group ( p < 0.001). In the sagittal plane, the sum of the superior aspect of the iliac bone and the inferior aspect of the ischium was significantly lower in the DDH group ( p = 0.001) than in the control group. The distances between the femoral heads and the acetabula were significantly greater in the DDH group than in the control group ( p = 0.03, p < 0.01, respectively)., Conclusions: Patients with DDH had a more internally rotated ilium and ischiopubic bone than normal individuals; however, it should be emphasized that internal rotation was reduced near the acetabulum, and the acetabulum was shifted laterally. Similarly, it was shown that patients with DDH had different rotations of the ilium and ischiopubic bone in the sagittal plane., Competing Interests: CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported., (Copyright © 2022 by The Korean Orthopaedic Association.)

Background: There is a paucity of studies on the iliac curvature in developmental dysplasia of the hip (DDH). Here, we examined the iliac curvature in DDH using three-dimensional computed tomography., Methods: We allocated cases with a center-edge angle of < 20° to the DDH group (55 cases) and cases with a center-edge angle of > 25° to the control group (57 cases) and measured the straight line (line A) between the anterior and posterior superior iliac spines. We examined which part of the iliac bone line A passes through and classified the results into 4 categories (type A, inside the iliac bone; type B, through the iliac bone; type C, outside the iliac bone; and type D, both inside and outside the iliac bone) to evaluate the iliac wing curvature. After measuring the area and internal surface of the iliac wing using line A, we examined the correlation between these values, the interspinous distance, the superior iliac angle, and the center-edge angle., Results: Distributions of the four types were compared between the two groups; there was no significant difference. The length of the portion of line A inside the ilium and the area formed by line A and the iliac wing, which shows the degree of iliac wing curvature, were not significantly different between the groups. There were no correlations between these values and the center-edge angle; however, there were weak positive correlations among the interspinous distance, the superior iliac angle, and the center-edge angle., Conclusions: The inward nature of the iliac bone in patients with DDH is mainly due to the internal rotation of the entire iliac bone and less likely due to the curvature of the iliac bone., Competing Interests: CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported., (Copyright © 2021 by The Korean Orthopaedic Association.)

Alkaptonuria-related rapidly destructive arthropathy of the hip joint has not been reported in detail with both imaging and histopathological findings in the literature. We, herein, presented the case of a 79-year-old male patient who suddenly started experiencing marked right hip pain. Radiography showed that the femoral head was spherical; however, after 3 months, approximately half of the femoral head was destroyed despite there being almost no change in the acetabulum. Radiographs of the spine also showed fusion between multiple vertebrae. Significant osteoporosis was observed on roentgenography, together with decreased bone density. Urinary gas chromatography-mass spectrometry analysis revealed that a large amount of homogentisic acid was excreted. During total hip arthroplasty, gray and muddy contents were observed in the joint capsule, and the surface of the destroyed femoral head was black. Histopathologically, granulomatous foci containing fragmented bone and cartilage debris were found in the bone marrow space of the joint surface, and the cartilage tissue was pigmented brownish black. The patient was subsequently diagnosed with ochronotic hip joint destruction. The present case report is the first to demonstrate rapidly destructive coxopathy associated with alkaptonuria using both imaging and histopathological findings. These findings clearly show that severe hip joint destruction defined as rapidly destructive hip arthropathy can occur in a very short time period for patients with alkaptonuria.

Background: Plain computed tomography (CT) and magnetic resonance imaging (MRI) are useful for diagnosing adverse local tissue reactions after metal-on-metal total hip arthroplasty (THA), but metal artifacts can hamper radiological assessments near the implants. We sought to clarify the usefulness of 18F-fluorodeoxyglucose positron-emission tomography (18F-FDG-PET) CT and MRI in the periprosthetic region, which is difficult to assess after THA due to metal artifacts., Methods: We performed preoperative 18F-FDG-PET/CT and 18F-FDG-PET/MRI, as well as plain CT and MRI, in 11 metal-on-metal THA patients who underwent revision surgery., Results: Most patients showed high FDG uptake in the metal artifact areas and pseudotumors in the 18-F-FDG-PET/CT and 18-F-FDG-PET/MRI scans. Intraoperative intra-articular macroscopic and histopathological intra-articular granulation tissue findings were suggestive of adverse local tissue reaction., Conclusions: The enhanced uptake in the metal artifact areas seemed to reflect adverse local tissue reaction. Therefore, 18F-FDG-PET/CT and 18-F-FDG-PET/MRI can be useful for the auxiliary diagnosis of adverse local tissue reactions after metal-on-metal THA., Competing Interests: CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported., (Copyright © 2021 by The Korean Orthopaedic Association.)

Age- or sex-related differences in femoral curvature affect the onset of trauma or degenerative diseases of the hip joints. This study aimed to investigate femoral curvature in detail in Japanese individuals using three-dimensional computed tomography, evaluate its effects on the position of proximal femur, and assess differences in femoral curvature according to age and sex. We measured sagittal and coronal femoral bowing in 40 elderly (mean age 85.2 years) and 40 adult (mean age 30.1 years) Japanese individuals using computed tomography. In adult individuals, the radii of the femoral curvatures of the distal end and shaft in the coronal planes were significantly smaller in women than in men. In contrast, no significant difference was observed in femoral curvature between the sexes in the elderly group. Furthermore, the radius of femoral curvature was significantly smaller in elderly individuals than in adult individuals, regardless of the sex and location of the measurement. The highest point of the greater trochanter of the femoral head center was 7.3 ± 5.6 mm in the elderly group and 2.2 ± 4.6 mm in the adult group (p < 0.05). Thus, the femoral curvature varies with age and sex in Japanese individuals. In addition, the femoral curvature could cause positional changes in the proximal femur, such as the highest point of the greater trochanter. Therefore, further studies investigating the biomechanical effects of these morphological changes are warranted.

Backgroud: In total hip arthroplasty, the cup setting angle may affect the postoperative results. In recent years, both computed tomography-based navigation and computed tomography-free (imageless) navigation have been reported to produce high accuracy in cup installation; however, no direct comparison between these two methods has been performed. The present study aimed to directly compare the cup installation angle accuracy between computed tomography-based navigation and computed tomography-free navigation in patients with Crowe's classification stage I or II dysplastic osteoarthritis and to examine the factors affecting the cup installation accuracy., Methods: Using both navigation systems for the same technique, primary total hip arthroplasty was performed by the same surgeon in 36 patients. A cup was installed using computed tomography-based navigation, and the installed cup was measured again using computed tomography-free navigation. We compared the error between the target angle and the intraoperative installation angle for each navigation method by performing statistical analyses., Results: For computed tomography-based navigation, errors in the inclination and the anteversion angles compared to the target angle were 3.14° ± 1.55° and 1.47° ± 0.99°, respectively. For computed tomography-free navigation, the inclination and anteversion angle errors were significantly larger, i.e., 6.84° ± 4.78° and 5.43° ± 5.22°, respectively ( p < 0.01). The inclination and anteversion angles of computed tomography-free navigation were correlated, and there were no significant factors influencing the error., Conclusions: Computed tomography-based navigation is more accurate for cup installation than computed tomography-free navigation. When using computed tomography-free navigation, it is necessary to add technical schemes before and during surgery to improve the cup installation accuracy., Competing Interests: CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported., (Copyright © 2021 by The Korean Orthopaedic Association.)

Background: We aimed to clarify the iliac anatomy in developmental dysplasia of the hip using three-dimensional computed tomography., Methods: The distance between two points along each anatomical portion of the ilium, including the acetabular center, were compared between patients in the dysplasia and control groups., Results: There were no significant differences in the upper part of the ilium between the groups. However, three distances that included the acetabular center were significantly shorter in the dysplasia group than in the control group., Conclusions: Our study suggests that bone dysplasia occurs in the ilium near the acetabulum, not in the iliac wings., Competing Interests: None., (© 2021 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.)

Backgroud: No study has compared flat and elevated-rim polyethylene liners in terms of stress distribution on the bearing surface. The purpose of this study was to investigate the difference in stress distribution between flat and elevated-rim polyethylene liners., Methods: A stress analysis was performed by using the 3-dimensional finite element method. The cup was placed at an open angle of 20°, the flat liner and the liner with a 10° elevation was placed at inclination angles of 80°, 70°, and 60°., Results: Compared with the 60° flat liner, the 80° and 70° flat liners showed higher stress at the liner edge. In the elevated-rim liner, the stress was high at the liner edge along the cup edge. When the von Mises equivalent stress was applied to each element of the liner, the high stress area (volume) was the largest for the 80° flat liner, second largest for the 80° elevated-rim liner, and third largest for the 70° flat liner. The average contact pressure also followed the same order., Conclusions: Elevated-rim liners affect the stress distribution by increasing the area of contact. However, since elevated-rim liners exhibit high stress at the cup edge, they are likely to result in new problems including liner failure. These findings could aid surgeons in the selection of liners and determination of revision methods such as isolated liner exchange vs. acetabular cup revision for a well-fixed metal cup with a higher inclination angle in revision total hip arthroplasty., Competing Interests: CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported., (Copyright © 2020 by The Korean Orthopaedic Association.)

We report herein the microstructure of the acetabular labrum obtained from a patient with stem loosening but without bipolar cup migration who had undergone hemiarthroplasty for femoral neck fracture 18 years ago. We used light and scanning electron microscopy to investigate the influence of bipolar cup on acetabular labrum in vivo. Deparaffinized blocks were treated with 2 N NaOH to digest the cell matrix, allowing the collagen fibers, constituting the acetabular labrum, to be observed under scanning electron microscopy. Although chondrocyte atrophy was seen, the basic structure was not different from the normal tissue images of the elderly. However, in the deep part of the acetabular labrum, there was an area that was not stained with Alcian blue observed with light microscopy, and there was an amorphous tissue without type II collagen fibrils observed with scanning electron microscopy. These findings proved that the acetabular labrum has partially degenerated over the long term after bipolar hemiarthroplasty, and that the acetabular labrum can survive in vivo in such a condition. Given that hemiarthroplasty has a possibility to preserve the face-to-face tissue in the long term in vivo, it may be one of the valuable options for modern or future joint reconstruction surgery.

We examined the ultrastructure of the anterior cruciate ligament and assessed age-related changes by comparing the ligaments of young and old monkeys. Ultrathin sections of the anterior cruciate ligament were observed by transmission electron microscopy. The three-dimensional architecture of collagen fibers in the ligament was examined by scanning electron microscopy after tissue specimens were treated with 2 N NaOH to digest the extracellular matrix. At the surface layer of the cruciate ligament in young monkeys, fusiform-shaped fibroblasts actively produced collagen fibrils. The ligament consisted of parallel bundles of dense collagen fibrils of approximately 200 nm in diameter. Collagen fibrils appeared to run linearly. Ligament fibrocytes in the deep layer had a stellate form. Ligament fibrocytes decreased in number and showed marked atrophy in old age. Collagen fibrils had a looser configuration in older monkeys. Despite atrophy of fibroblasts in the deep layer of the anterior cruciate ligament, the area with atrophic fibroblasts in the ligament expands with age, which can likely cause deterioration of and a reduction in collagen fibers. This information can be applied in studies on the cause of the low repair ability of and aging-related changes in the anterior cruciate ligament in humans.

The acetabular labrum is frequently damaged with advancing age. As collagen fibers are the main sources of strength, knowledge of their ultrastructure is important to determine the cause of age-induced changes. We aimed to investigate the ultrastructure of collagen fibers constituting the acetabular labrum using scanning electron microscopy (SEM). Acetabular labrum samples obtained during total hip arthroplasty were studied. The samples were specially prepared to observe the steric construction of collagen fibrils constituting the acetabular labrum under light microscopy followed by SEM. The acetabular labrum was mostly composed of cartilage tissue, consisting of chondrocytes and collagen type II, with a layer of collagen type I. In adults, chondrocytes with a rich cytoplasm were surrounded by a dense network of fine type II collagen fibrils, and small bundles of type I collagen fibrils were interposed in the cartilage layer. In elderly individuals, the chondrocytes atrophied and both type I and II collagen fibrils were sparse. We suggest that cartilage has three to five layers, consisting of type I and type II collagen fibrils with a solid cartilage substrate. In elderly individuals, the density of chondrocytes decreases and the cellular shape and architecture of collagen fibrils also changes.

Background: Studies comparing cementless and cemented cups are lacking, especially for revision total hip arthroplasty (THA). The aim of this study was to investigate and compare the differences in implant accuracy between two fixation methods in revision THA., Methods: We conducted a retrospective study of 85 hips in 70 patients who underwent revision THA using a computed tomography (CT)-based navigation system. Among these, 53 hips underwent cementless THA and 32 hips underwent cemented THA. We measured cup inclination and anteversion using the Kyocera two-dimensional-template with X-ray (Japan-Kyocera, Shiga, Japan) and stem anteversion with CT. We calculated the combined anteversion [cup anteversion+0.7×stem anteversion]., Results: There were no significant differences between the two groups with respect to definitive cup inclination and anteversion. The mean deviations in the inclination and anteversion angle were 40.3 ± 4.3 and 19.6 ± 6.2° in the cementless group and 40.5 ± 3.3 and 17.1 ± 5.1° in the cemented group. There were 11 outliers with respect to the Lewinnek safe zone in the cementless group and two in the cemented group (P = 0.072). Although there was no statistically significant difference, the number of safe zone outliers in the cemented group was less than that in the cementless group., Conclusion: We conclude that when using a navigation system for revision THA, high precision can be obtained for the cup placement angle with or without cement. However, it seems that a major error in the installation angle of the cup is less likely to occur when using a cemented cup than when using a cementless cup in revision THA with a navigation system., (© 2019 Delhi Orthopedic Association. All rights reserved.)

Background: In isolated acetabular revision surgery, surgeons must place the cup at an appropriate angle with various retained stem anteversion angles to prevent postoperative dislocation. For accurate acetabular cup position, various navigation systems have been used. Nevertheless, no publications have reported combined cup and stem anteversion and dislocation rates after isolated acetabular revision, especially comparing the use of navigation with manual implantation. Therefore we performed a retrospective comparative study to answer the following questions: (1) What is the combined anteversion after isolated acetabular revision with computed tomography-based navigation? (2) Does navigation improve the accuracy of cup angle and combined anteversion, (3) reduce dislocation rate, and (4) reduce operative time?, Hypothesis: A navigation system makes combined anteversion near the target angle in isolated acetabular revision., Patients and Methods: We conducted a retrospective study of 32 hips in 24 patients who underwent isolated acetabular revision total hip arthroplasty using computed tomography-based navigation system. The control group comprised 8 hips in 8 patients who underwent the same procedure without navigation., Results: In the navigation group, average Widmer's combined anteversion was 39.0°±8.7° (range, 25.3°-56.6°). Cup positions were 40.3°±2.9° (range, 29.0°-49.0°) for radiographic abduction angle, 24.3°±8.0° (range, 4.6°-42.6°) for radiographic anteversion. In the control group, Widmer's combined anteversion was 47.2°±15.1° (range, 27.0°-74.3°, p=0.048). The average cup positions for radiographic abduction angle and anteversion were 36.7°±8.9° (range, 24.5°-54.9°) and 29.1°±7.3° (range, 17.2°-38.8°), respectively (p>0.05). Widmer's combined anteversion deviated from the target angle by a smaller amount in the navigation group than in the control group: errors in measurement of Widmer's combined anteversion were 7.2°±5.1° (range, 0.74°-19.6°) in the navigation group and 13.9°±11.1° (range, 3.6°-37.3°) in the control group (p=0.135). Postoperative dislocation occurred in none of the 32 hips (0%) in the navigation group and in one of the 8 hips (12.5%) in the control group (p=0.2)., Discussion: Using the navigation system, combined anteversion is made near the target angle in isolated acetabular revision surgery and more accurately than manual implantation. These results should be considered as preliminary since this is a limited cohort, but it brings new knowledge in navigation considering the very limited number of series using of navigation in isolated cup revision of total hip arthroplasty. In addition this is the first study to investigate combined cup and stem anteversion in isolated acetabular revision. The use of CT-scan is helpful to diagnose error in stem anteversion and to adapt the orientation of the new cup., Level of Evidence: III, Retrospective case control study., (Copyright © 2019 Elsevier Masson SAS. All rights reserved.)

Simulations using three-dimensional computer-aided design were performed with the various conditions to research the movement distance of the ball head and total range of motion until impingement and dislocation (ROM(t)) which involved in joint stability. Although a large ball head increases the entire ROM(t) and oscillation angle, it decreases stability transitioning from impingement to dislocation. Conversely, though large neck diameter increases the simulated stability from impingement to dislocation, it reduces the ROM(t) and oscillation angle. ROM(t) decreases with change in neck shape and is greatly affected by the presence of osteophytes, even if the head-neck ratio remains the same., (© 2019 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.)

We aimed to clarify the possibility of using bipolar hip arthroplasty (BHA) for degenerative diseases by examining long-term results postoperatively in 336 hips. Patients' average age was 61.0 years (range, 34-88 years), and the average follow-up period was 12.5 years (range, 5.0-27.3 years). The 5-year, 10-year, and 20-year Kaplan Meier survival rates (end point: revision) were 92.1%, 81.8%, and 20.1% in the osteoarthritis group and 96.4%, 90.1%, and 24.6% in the rheumatoid arthritis group, respectively. Since the survival rate for more than 10 years decreases rapidly, the use of BHA for treating degenerative diseases should be restricted., (© 2019 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.)

Background: The aim of this study is to determine the influence of crosslinking and addition of 0.3 wt% vitamin E in a polyethylene rim on its mechanical damage and oxidation caused by impingement., Methods: Six ultrahigh-molecular weight polyethylene samples were studied (control; crosslinked; vitamin-E containing; crosslinked and vitamin-E containing; aged control; and aged crosslinked and vitamin-E containing). Crosslinking was attained by irradiation with a 300 kGy electron beam; vitamin E incorporation was at 0.3 wt%; and aging was performed through forced oxidation for 14 days. Resistance to impingement was evaluated by stereoscopic observations, three-dimensional measurements, and oxidation measurements by Fourier transform infrared spectroscopy., Findings: Rim breakage (delamination and fracture) due to impingement was observed only for the aged control specimen. In contrast, crosslinked specimens containing vitamin E showed no failure of the rim after aging. The addition of vitamin E to polyethylene suppressed its oxidation and reduced the oxidation caused by crosslinking or impingement. The impingement resistance of the control sample deteriorated upon oxidation, whereas that of vitamin E-containing crosslinked polyethylene remained high due to the antioxidant property of vitamin E., Interpretation: Vitamin E-containing polyethylene showed a reduced risk of wear/breakage of polyethylene rims by impingement., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Background: The indications for bipolar hemiarthroplasty (BHA) have been narrowing as those for total hip arthroplasty (THA) have been expanding in cases of femoral neck fracture and initial stages of osteonecrosis of femoral head (ONFH). It is difficult to measure wear in vivo after BHA because the equipment used has a dual bearing system with an inner head inside a metal outer cup. The present study aimed to (1) use a roentgenograph to measure linear wear in vivo after BHA with different acetabular conditions around the bipolar cup, and (2) compare the linear wear of polyethylene between integral bipolar cup (IBC) and Centrax prostheses., Methods: From among patients who had undergone BHA in our department after 1996, we analyzed 48 joints with osteoarthritis (OA) and without acetabular cartilage, as well as 25 joints with ONFH of stage 3 or less, in which the acetabular cartilage remains. Two types of bipolar cup prostheses were used: the IBC, which was gamma-sterilized in air using 2-Mrad irradiation, and the Centrax, which was gamma-sterilized in nitrogen using 3-Mrad irradiation. To image the inner head in vivo , we used high-pressure X-ray photography; we measured linear wear of the polyethylene with software using Martell Method 1., Results: Comparing mean annual linear wear between the OA and ONFH groups, using IBC prostheses in both groups, there was a significant difference (0.213 mm vs. 0.096 mm, respectively; P  = 0.0177 ). There was a significant difference between the Centrax and IBC prostheses in OA patients in terms of linear wear (0.04 mm vs. 0.213 mm; P  = 0.0181)., Conclusion: The linear wear of polyethylene in BHA implants can be affected by the material used to manufacture the bipolar cup. Such implants should only be used for appropriate indications.

Total hip arthroplasty (THA) can eliminate pain caused by hip joint destruction and correct leg-length discrepancies (LLD). We present a short and simple intraoperative method for LLD correction in THA. We performed 55 primary THAs using this technique. The measurement error was 1.86 ± 1.4 mm, which was within 3 mm in 49 of 55 cases (89%) and within 5 mm in 54 of 55 cases (98%). This method is simple and does not require specialized devices, making it versatile to be used anywhere. No new skin incisions or extra costs are required, which will likely make it attractive to surgeons.

Background: Navigation systems are an effective tool to improve the installation accuracy of the cup in primary total hip arthroplasty. This study aimed to evaluate the efficacy of a computed tomography-based navigation system in achieving optimal installation accuracy of implants in revision total hip arthroplasty and to clarify the usefulness of the navigation system., Methods: We conducted a retrospective study of 23 hips in 23 patients who underwent revision total hip arthroplasty using a computed tomography-based navigation system; the control group comprised 33 hips in 33 patients who underwent revision total hip arthroplasty without a navigation system., Results: The average cup position with the navigation system was 40.0° ± 3.7° in radiographic abduction angle, 18.8° ± 4.8° in radiographic anteversion, and 41.2° ± 8.9° in combined anteversion; without the navigation system, the average cup position was 38.7° ± 6.1°, 19.0° ± 9.1°, and 33.6° ± 20.5°, respectively. The achievement rate of cup positioning within the Lewinnek safe zone was not significantly different between the navigation group (82.6%) and control group (63.6%). In contrast, the achievement rate of cup positioning within the Widmer combined anteversion guidelines was significantly greater in the navigation group (78.3%) than in the control group (48.0%, p = 0.029). Furthermore, outlier cases in the navigation group had a smaller variance of deviation from the optimal cup position than those in the control group did., Conclusions: The results show that the use of navigation for revision total hip arthroplasty improved cup positioning and reduced the range of outliers. Improvement of cup placement accuracy influenced the installation of the stem and also improved the achievement rate of combined anteversion. Thus, a computed tomography-based navigation system is very useful for surgeons when placing the cup within the target angle in revision total hip arthroplasty., Competing Interests: CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported.

Background: Acetabular component orientation, such as high placement and femoral head diameter influence joint stability in total hip arthroplasty (THA), wherein anterior inferior iliac spine (AIIS) shape could cause femoro-acetabular impingement. Little is known regarding the combined influence of these parameters, particularly in the context of developmental dysplasia of the hip. Therefore we conducted a computer simulation study based on computed tomography (CT) data to determine whether: (1) AIIS shape, (2) high placement of acetabular cups, and (3) ball head diameter influence the range of motion (ROM) after THA., Hypothesis: The decrease in ROM depends on AIIS shape and the ROM decreases even if the femoral head diameter is increased when high placement of acetabular cups., Patients and Methods: CT data from 14 hips of 14 patients were evaluated. Hips were categorized by Hetsroni classification type I (n=6), type II (n=6), and type III (n=2) depending on AIIS shape. ROM was evaluated using CT-based software. Cups were placed at and 5 and 10mm above the normal hip position. The femoral heads used were 28 (standard simulation), 32, and 36mm in diameter. ROM at impingement was measured under flexion (Flex), internal rotation (IR) at 90° flexion (IR at 90Flex), IR at 45° flexion with a 20° adduction (IR at 45Flex20Add), and external rotation at 10° extension (ER at 10Ext)., Results: The mean ROM standard simulation for Flex, IR at 90Flex, IR at 45Flex20Add and ER at 10Ext were: 119.8±5.4°, 31.0±11.3°, 70.0±11.9°, and 33.0±9.7° for type I; 118.5±5.5°, 31.5±2.9°, 71.3±2.2°, and 33.3±3.3° for type II; and 105.5±13.4°, 21.0±15.6°, 61.0±11.3°, and 34.5±2.1° for type III, respectively. There were no significant differences in the ROMs of each type (Flex, p=0.252; IR at 90Flex, p=0.461; IR at 45Flex20Add, p=0.261; and ER at 10Ext, p=0.655). For the high placement of acetabular cups, ROM increase was restricted despite the femoral head diameter increase., Discussion: Larger femoral head diameters increased ROM, with a lower increase in type III because of bony impingement. ROM decreased with higher cup placement. Expansion effects were minimal, even with larger ball head diameters, and were further decreased in types II and III. Attention should be paid to AIIS shape because bony impingements occur early with higher acetabular cup placement., Level of Evidence: VI Simulation study., (Copyright © 2018 Elsevier Masson SAS. All rights reserved.)

Background: We aimed to investigate the three-dimensional structure of the collagenous fibers of the ligamentum teres (LT) of the human hip and clarify the LT micro-anatomy at the attachment of the femoral head., Methods: Femoral heads and LT were collected during hip arthroplasty. Specimens were cut into 5-10-mm squares, prepared, developed, and observed under a light microscope. Next, specimens were prepared and examined under a scanning electron microscope (SEM)., Results: Under optical microscope, LT adhered to the artificial cartilage at the attachment of the femoral head. Under SEM, LT comprised parallelly arranged collagenous fibers and the fine collagenous fibrils were twisted. While the central collagenous fibers of the LT at the attachment of the femoral head penetrated the articular cartilage tissue and reached the ring-shaped bone, fibers at the margin traversed and adhered to the cartilage surface., Conclusion: Articular cartilage and subchondral bone are present at the LT attachment to the femoral head. Although collagenous fibers of the LT show parallel arrangement at the main trunk, they are dispersed at the cartilage surface and not all reach the thin subchondral bone of the femoral head. This could possibly weaken ligament strength at the attachment of the femoral head., Level of Evidence: IV., Competing Interests: Conflict of interest The Authors have no financial or personal relationships with other people or organizations that could inappropriately influence their work.

Background: Regarding the cup setting in total hip arthroplasty, range of motion and prevention of dislocation are important. From past reports, the wear of the bearing surface may affect long-term results. This study evaluated the stress applied to the bearing surface by the combined use of the three-dimensional rigid spring model and the finite-element analysis., Methods: For contact pressure distribution of the bearing surface, interference analysis was performed using a three-dimensional rigid body spring model. Furthermore, stress was applied to the inner surface of the cup installed in the bone so that the same stress distribution obtained from the interference analysis was achieved. The finite-element analysis was then performed at each condition, which changed the inclination and anteversion angles of the cup to examine the relationship of maximum equivalent stress., Results and Discussion: The maximum equivalent stresses on the bearing surface under the condition with fixation of an anteversion angle of 0° were 0.78, 0.85, and 1.15 MPa at inclination angles of 25°, 40°, and 55°, respectively. The stress value at 55° was approximately 1.5 times greater than that at 25°. The maximum equivalent stresses on the bearing surface under the condition with fixation of an inclination angle of 40° were 0.85, 0.9, and 1.02 MPa at anteversion angles of 0°, 15°, and 30°, respectively. The stress value at 30° was approximately 1.2 times greater than that at 0°. This study suggests that large inclination and anteversion angles may enhance the stress on the bearing surface and affect long-term results.

Introduction: In bipolar hemiarthroplasty, migration of the outer cup component into the acetabular cup, with evidence of severe osteolysis in the acetabulum, commonly occurs without loosening of the femoral component. The merits of retaining the stable femoral component in these cases have been debated. Our study aimed to determine whether revision of the acetabular component in isolation could be successfully performed., Materials and Methods: The data of 54 patients (61 hips), 44 women, and 10 men, aged 67.7 (range 47-86) years at the time of the index revision, were analyzed. The average time from primary operation to revision surgery was 14.9 (range 1.0-27.0) years, with an average follow-up time after revision of 5.2 (range, 1.0-18.7) years. Indications for acetabular revision included migration of the outer cup component (N = 55), disassembly of the bipolar cup (N = 4), and recurrent dislocation (N = 2). Fixation of the femoral stem was cementless in 49 hips and cemented in 12. Bone grafting for osteolysis of the proximal femur around the stem was performed in six hips. An acetabular reinforcement ring with a cemented cup was used in 31 hips, with cementless cup fixation in 29 hips, and cemented cup in one case., Results: On average, the Harris hip score improved from 57.0 ± 21.6 to 87.4 ± 6.40 points after revision. Two cases of femoral periprosthetic fracture were treated with osteosynthesis 3 year post-revision. There was no evidence of loosening of the femoral stem or subsidence, with a non-progressive radiolucent line <2 mm identified in one case. There was no incidence of dislocation or deep infection, and all components were judged to be stable at the final follow-up., Conclusion: Isolated acetabular revision can be reliably performed in cases of failed bipolar hemiarthroplasty with a well-fixed femoral component.