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2. Effects of a 2-year exercise training on neuromuscular system health in older individuals with low muscle function

Author

Monti, E., Tagliaferri, S., Zampieri, S., Sarto, F., Sirago, G., Franchi, M. V., Ticinesi, A., Longobucco, Y., Adorni, E., Lauretani, F., Von Haehling, S., Marzetti, Emanuele, Calvani, Riccardo, Bernabei, Roberto, Cesari, M., Maggio, M., Narici, M. V., Marzetti E. (ORCID:0000-0001-9567-6983), Calvani R. (ORCID:0000-0001-5472-2365), Bernabei R. (ORCID:0000-0002-9197-004X), Monti, E., Tagliaferri, S., Zampieri, S., Sarto, F., Sirago, G., Franchi, M. V., Ticinesi, A., Longobucco, Y., Adorni, E., Lauretani, F., Von Haehling, S., Marzetti, Emanuele, Calvani, Riccardo, Bernabei, Roberto, Cesari, M., Maggio, M., Narici, M. V., Marzetti E. (ORCID:0000-0001-9567-6983), Calvani R. (ORCID:0000-0001-5472-2365), and Bernabei R. (ORCID:0000-0002-9197-004X)

Abstract

Background: Ageing is accompanied by a progressive loss of skeletal muscle mass and strength, potentially determining the insurgence of sarcopenia. Evidence suggests that motoneuron and neuromuscular junction (NMJ) degeneration contribute to sarcopenia pathogenesis. Seeking for strategies able to slow down sarcopenia insurgence and progression, we investigated whether a 2-year mixed-model training involving aerobic, strength and balance exercises would be effective for improving or preserving motoneuronal health and NMJ stability, together with muscle mass, strength and functionality in an old, sarcopenic population. Methods: Forty-five sarcopenic elderly (34 females; 11 males) with low dual-energy X-ray absorptiometry (DXA) lean mass and Short Physical Performance Battery (SPPB) score <9 were randomly assigned to either a control group [Healthy Aging Lifestyle Education (HALE), n = 21] or an intervention group [MultiComponent Intervention (MCI), n = 24]. MCI trained three times per week for 2 years with a mix of aerobic, strength and balance exercises matched with nutritional advice. Before and after the intervention, ultrasound scans of the vastus lateralis (VL), SPPB and a blood sample were obtained. VL architecture [pennation angle (PA) and fascicle length (Lf)] and cross-sectional area (CSA) were measured. As biomarkers of neuronal health and NMJ stability status, neurofilament light chain (NfL) and C-terminal agrin fragment (CAF) concentrations were measured in serum. Differences in ultrasound parameters, NfL and CAF concentration and physical performance between baseline and follow-up were tested with mixed ANOVA or Wilcoxon test. The relationship between changes in physical performance and NfL or CAF concentration was assessed through correlation analyses. Results: At follow-up, MCI showed preserved VL architecture (PA, Lf) despite a reduced CSA (−8.4%, P < 0.001), accompanied by maintained CAF concentration and ameli

Published
2023

3. 3D printed inks of two-dimensional semimetallic MoS2/TiS2 nanosheets for conductive-additive-free symmetric supercapacitors.

Author

Panagiotopoulos, A., Nagaraju, G., Tagliaferri, S., Grotta, C., Sherrell, P. C., Sokolikova, M., Cheng, G., Iacoviello, F., Sharda, K., and Mattevi, C.

Abstract

The semimetallic 1T′ and 1T phases of two-dimensional (2D) transition metal dichalcogenides (TMDs) have been attracting considerable attention as promising materials for electrochemical technologies owing to their intrinsic electrical conductivity and exceptionally high ion-intercalation properties. Achieving the 1T′ phase of MoS2 in high concentration and preserving it during device operation are still pressing challenges as the phase is metastable. Herein, we demonstrate 3D printed electrodes of 1T′/1T MoS2/TiS2 nanosheets for microsupercapacitors. The highly concentrated water-based inks of exfoliated 1T′/1T MoS2/TiS2 nanosheets were suitable for the printing of 3D architectures with arbitrary geometry, micron-sized features and spatial uniformity. Such architectures are used as microsupercapacitor electrodes which exhibit an areal capacitance of 448.16 mF cm−2 at a current density of 0.1 mA cm−2. TMD-based microsupercapacitors with high-mass loading (up to 100 mg cm−2) 3D electrodes also exhibited excellent cycling stability and coulombic efficiency over 100 000 cycles, while retaining the 1T′ phase. Overall, the high mass loading of the printed electrode and the conductivity and the geometry of the electrodes contribute to achieving energy and power density (3.89 μW h cm−2 and 250 μW cm−2, respectively) which are prime amongst those of the TMD-based supercapacitors. This work demonstrates the possibility of formulating and processing inks of 2D TMDs without conductive additives, paving the way towards the manufacturability of electrically conductive device components based on metastable materials. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Treatment of Delirium in Older Persons: What We Should Not Do!

Author

Lauretani, F, Bellelli, G, Pela, G, Morganti, S, Tagliaferri, S, Maggio, M, Lauretani F., Bellelli G., Pela G., Morganti S., Tagliaferri S., Maggio M., Lauretani, F, Bellelli, G, Pela, G, Morganti, S, Tagliaferri, S, Maggio, M, Lauretani F., Bellelli G., Pela G., Morganti S., Tagliaferri S., and Maggio M.

Abstract

The presentation of common acute diseases in older age is often referred to as "atypical". Frequently, the symptoms are neither single nor tissue related. In most cases, the onset of symptoms and diseases is the expression of a diminished reserve with a failure of the body system and imbalance of brain function. Delirium is one of the main devastating and prevalent atypical symptoms and could be considered as a geriatric syndrome. It encompasses an array of neuropsychiatric symptoms and represents a disarrangement of the cerebral function in response to one or more stressors. The most recent definition, reported in the DSM-V, depicts delirium as a clear disturbance in attention and awareness. The deficit is to be developed in a relatively short time period (usually hours or days). The attention disorder must be associated with another cognitive impairment in memory, orientation, language, visual-spatial or perception abilities. For the treatment, it is imperative to remove the potential causes of delirium before prescribing drugs. Even a non-pharmacological approach to reducing the precipitating causes should be identified and planned. When we are forced to approach the pharmacological treatment of hyperactive delirium in older persons, we should select highly cost-effective drugs. High attention should be devoted to the correct balance between improvement of psychiatric symptoms and occurrence of side effects. Clinicians should be guided in the correct choice of drugs following cluster symptoms presentation, excluding drugs that could potentially produce complications rather than advantages. In this brief point-of-view, we propose a novel pharmacological flow-chart of treatment in relation to the basic clusters of diseases of an older patient acutely admitted to the hospital and, in particular, we emphasize "What We Should Not Do!", with the intention of avoiding possible side effects of drugs used.

Published
2020

5. Do Smokers' Perceptions of the Harmfulness of Nicotine Replacement Therapy and Nicotine Vaping Products as Compared to Cigarettes Influence Their Use as an Aid for Smoking Cessation? Findings from the ITC Four Country Smoking and Vaping Surveys

Author

Yong, H-H, Gravely, S, Borland, R, Gartner, C, Cummings, KM, East, K, Tagliaferri, S, Elton-Marshall, T, Hyland, A, Bansal-Travers, M, Fong, GT, Yong, H-H, Gravely, S, Borland, R, Gartner, C, Cummings, KM, East, K, Tagliaferri, S, Elton-Marshall, T, Hyland, A, Bansal-Travers, M, and Fong, GT

Abstract

INTRODUCTION: This study examined whether smokers' harm perceptions of nicotine replacement therapy (NRT) and nicotine vaping products (NVPs) relative to cigarettes predicted their subsequent use as smoking cessation aids during their last quit attempt (LQA). AIMS AND METHODS: We analyzed data from 1,315 current daily smokers (10+ cigarettes per day) who were recruited at Wave 1 (2016), and who reported making a quit attempt by Wave 2 (2018) of the International Tobacco Control Four Country Smoking and Vaping Surveys in Australia, Canada, England, and the United States. We used multinomial logistic regression models to examine prospective associations between harm perceptions of (a) NRT and (b) NVPs and their use at LQA, controlling for socio-demographic and other potential confounders. RESULTS: Smokers who perceive that (a) NRT and (b) NVPs are much less harmful than cigarettes were more likely to subsequently use the respective product as an aid than using no aid or other aids during LQA (adjusted relative risk ratio [aRRR] = 3.79, 95%CI = 2.16-6.66; and aRRR = 2.11, 95%CI = 1.29-3.45, respectively) compared to smokers who perceive these products as equally or more harmful. Additionally, those who perceive NVPs as much less harmful than cigarettes were less likely to use NRT as a quit aid (aRRR = 0.34, 95%CI = 0.20-0.60). No country variations for these associations were found. CONCLUSIONS: This study found that smokers' perceptions of the harmfulness of (a) NRT and (b) NVPs relative to cigarettes predicted the respective product use when trying to quit smoking. Corrective education targeting misperceptions of nicotine products' relative harmfulness may facilitate their use for smoking cessation. IMPLICATIONS: Nicotine replacement therapy and nicotine vaping products are two commonly used smoking cessation aids. This study demonstrates that misperceptions of the harms of nicotine products relative to cigarettes influence their use for smoking cessation. Believing

Published
2022

6. Prevalence of Gastrointestinal Symptoms in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Results of the Prospective Controlled Multinational GI-COVID-19 Study

Author

Marasco, G., Cremon, C., Barbaro, M. R., Salvi, D., Cacciari, G., Kagramanova, A., Bordin, D., Drug, V., Miftode, E., Fusaroli, P., Mohamed, S. Y., Ricci, C., Bellini, M., Rahman, M. M., Melcarne, L., Santos, J., Lobo, B., Bor, S., Yapali, S., Akyol, D., Sapmaz, F. P., Urun, Y. Y., Eskazan, T., Celebi, A., Kacmaz, H., Ebik, B., Binicier, H. C., Bugdayci, M. S., Yagci, M. B., Pullukcu, H., Kaya, B. Y., Tureyen, A., Hatemi, I., Koc, E. S., Sirin, G., Caliskan, A. R., Bengi, G., Alis, E. E., Lukic, S., Trajkovska, M., Hod, K., Dumitrascu, D., Pietrangelo, A., Corradini, E., Simren, M., Sjolund, J., Tornkvist, N., Ghoshal, U. C., Kolokolnikova, O., Colecchia, A., Serra, J., Maconi, G., De Giorgio, R., Danese, S., Portincasa, P., Di Stefano, M., Maggio, M., Philippou, E., Lee, Y. Y., Venturi, A., Borghi, C., Zoli, M., Gionchetti, P., Viale, P., Stanghellini, V., Barbara, G., Piacentini, A., Shengelia, M., Vechorko, V., Cardamone, C., Rosei, C. A., Pancetti, A., Rettura, F., Pedrosa, M., Campoli, C., Mijac, D., Korac, M., Karic, U., Markovic, A., Najdeski, A., Nikolova, D., Dimzova, M., Lior, O., Shinhar, N., Perelmutter, O., Ringel, Y., Sabo, C. M., Chis, A., Bonucchi, G., Caio, G. P. I., Ghirardi, C., Marziani, B., Rizzello, B., Aguilar, A., Capogreco, A., Aghemo, A., Di Paolo, D. M., Marconi, G., Di Sabatino, A., Tagliaferri, S., Naves, J. E., Galli, A., Dragoni, G., Nedelcu, L., Mauloni, P. A., Del Vecchio, S., Rotondo, L., Capuani, F., Montanari, D., Palombo, F., Paone, C., Mastel, G., Fontana, C., Bellacosa, L., Cogliandro, R. F., Marasco, Giovanni, Cremon, Cesare, Barbaro, Maria Raffaella, Salvi, Daniele, Cacciari, Giulia, Kagramanova, Anna, Bordin, Dmitry, Drug, Vasile, Miftode, Edgidia, Fusaroli, Pietro, Mohamed, Salem Youssef, Ricci, Chiara, Bellini, Massimo, Rahman, M Masudur, Melcarne, Luigi, Santos, Javier, Lobo, Beatriz, Bor, Serhat, Yapali, Suna, Akyol, Deniz, Sapmaz, Ferdane Pirincci, Urun, Yonca Yilmaz, Eskazan, Tugce, Celebi, Altay, Kacmaz, Huseyin, Ebik, Berat, Binicier, Hatice Cilem, Bugdayci, Mehmet Sait, Yağcı, Munkhtsetseg Banzragch, Pullukcu, Husnu, Kaya, Berrin Yalınba, Tureyen, Ali, Hatemi, İbrahim, Koc, Elif Sitre, Sirin, Goktug, Calıskan, Ali Riza, Bengi, Goksel, Alıs, Esra Ergun, Lukic, Snezana, Trajkovska, Meri, Hod, Keren, Dumitrascu, Dan, Pietrangelo, Antonello, Corradini, Elena, Simren, Magnu, Sjolund, Jessica, Tornkvist, Navkiran, Ghoshal, Uday C, Kolokolnikova, Olga, Colecchia, Antonio, Serra, Jordi, Maconi, Giovanni, De Giorgio, Roberto, Danese, Silvio, Portincasa, Pietro, Di Stefano, Michele, Maggio, Marcello, Philippou, Elena, Lee, Yeong Yeh, Venturi, Alessandro, Borghi, Claudio, Zoli, Marco, Gionchetti, Paolo, Viale, Pierluigi, Stanghellini, Vincenzo, and Barbara, Giovanni

Subjects
Male, medicine.medical_specialty, Settore MED/17 - Malattie Infettive, Coronavirus disease 2019 (COVID-19), Nausea, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), diarrhea, Disease, Gastrointestinal Symptoms, COVID-19, Acute Respiratory Syndrome, GI-COVID-19, NO, Russia, Manifestations, Interviews as Topic, Rating scale, Internal medicine, Surveys and Questionnaires, parasitic diseases, medicine, Prevalence, Humans, In patient, Prospective Studies, Respiratory system, Settore MED/12 - Gastroenterologia, Hepatology, business.industry, SARS-CoV-2, pandemic, Gastroenterology, COVID-19, Middle Aged, gastrointestinal, Gastroenteritis, Europe, Hospital admission, Egypt, Female, medicine.symptom, business, human activities
Abstract

INTRODUCTION: Gastrointestinal (GI) symptoms in coronavirus-19 disease (COVID-19) have been reported with great variability and without standardization. In hospitalized patients, we aimed to evaluate the prevalence of GI symptoms, factors associated with their occurrence, and variation at 1 month. METHODS: The GI-COVID-19 is a prospective, multicenter, controlled study. Patients with and without COVID-19 diagnosis were recruited at hospital admission and asked for GI symptoms at admission and after 1 month, using the validated Gastrointestinal Symptom Rating Scale questionnaire. RESULTS: The study included 2036 hospitalized patients. A total of 871 patients (575 COVID+ and 296 COVID-) were included for the primary analysis. GI symptoms occurred more frequently in patients with COVID-19 (59.7%; 343/575 patients) than in the control group (43.2%; 128/296 patients) (P < 0.001). Patients with COVID-19 complained of higher presence or intensity of nausea, diarrhea, loose stools, and urgency as compared with controls. At a 1-month follow-up, a reduction in the presence or intensity of GI symptoms was found in COVID-19 patients with GI symptoms at hospital admission. Nausea remained increased over controls. Factors significantly associated with nausea persistence in COVID-19 were female sex, high body mass index, the presence of dyspnea, and increased C-reactive protein levels. DISCUSSION: The prevalence of GI symptoms in hospitalized patients with COVID-19 is higher than previously reported. Systemic and respiratory symptoms are often associated with GI complaints. Nausea may persist after the resolution of COVID-19 infection., Fondazione Cassa di Risparmio in Bologna; Italian Ministry of Education, University and Research; Fondazione del Monte di Bologna e Ravenna [SC1-BHC-01-2019]; European Grant H2020, DISCOvERIE [SC1-BHC-01-2019]; Italian Ministry of Health [Ricerca Finalizzata GR-2018-12367062], G.B. contribution to this research was permitted in part by funding from Fondazione Cassa di Risparmio in Bologna; the ItalianMinistry of Education, University and Research; and Fondazione del Monte di Bologna e Ravenna and European Grant H2020, DISCOvERIE, SC1-BHC-01-2019. M.R.B. is a recipient of a grant from the Italian Ministry of Health (Ricerca Finalizzata GR-2018-12367062). None of the funding organizations have had any role in the design and conduct of the study; in the collection, management, and analysis of the data; or in the preparation, review, and approval of the article.

Published
2022

7. The sarcopenia and physical frailty in older people: multi-component treatment strategies (SPRINTT) project: description and feasibility of a nutrition intervention in community-dwelling older Europeans

Author

Jyvakorpi S. K., Ramel A., Strandberg T. E., Piotrowicz K., Blaszczyk-Bebenek E., Urtamo A., Rempe H. M., Geirsdottir O., Vagnerova T., Billot M., Larreur A., Savera G., Soriano G., Picauron C., Tagliaferri S., Sanchez-Puelles C., Cadenas V. S., Perl A., Tirrel L., Ohman H., Weling-Scheepers C., Ambrosi S., Costantini A., Pavelkova K., Klimkova M., Freiberger E., Jonsson P. V., Marzetti E., Pitkala K. H., Landi F., Calvani R., Bernabei R., Boni C., Brandi V., Broccatelli M., Celesti C., Cicchetti A., Collamati A., Coretti S., D'Angelo E., D'Elia M., Landi G., Lorenzi M., Mariotti L., Martone A. M., Ortolani E., Pafundi T., Picca A., Ruggeri M., Salini S., Tosato M., Vetrano D. L., Lattanzio F., Baldoni R., Bernabei S., Bonfigli A. R., Bustacchini S., Carrieri B., Cassetta L., Cherubini A., Cucchi M., Cucchieri G., Costantini A. R., Dell'Aquila G., Espinosa E., Fedecostante M., Fraternali R., Galeazzi R., Mengarelli A., Piomboni S., Posacki E., Severini E., Tregambe T., Trotta F., Maggio M., Lauretani F., Butto V., Fisichella A., Guareschi C., Longobucco Y., Di Bari M., Rodriguez-Manas L., Alamo S., Bouzon C. A., Gonzales Turin J., Zafra O. L. L., Picazo A. L., Sepulveda L. P., SanchezSanchez J. L., Puelles C. S., Aragones M. V., CruzJentoft A. J., Santos J. A., Alvarez-Nebreda L., JimenezJimenez N. F., Nozal J. M. -D., Montero-Errasquin B., Moreno B. P. B. P., Roldan-Plaza C., Vicente A. R. -D., Sanchez-Cadenas V., Sanchez-Castellano C., Sanchez-Garcia E., Vaquero-Pinto M. N., Topinkova E., Bautzka L., Blechova K., Gueye T., Juklickova I., Klbikova T., Krenkova J. J., Madlova P., Mejstrikova H., Melcova R., Michalkova H., Ryznarova I., Drastichova I., Hasalikova E., Hucko R., Jakub S., Janacova M., Kilmkova M., Parizkova M., Redrova M., Ruskova P. P., Sieber C. C., Auerswald T., Engel C., Franke A., Freibergen E., Freiheit U., Gotthardt S., Kampe K., Kob R., Kokott C., Kraska C., Meyer C., Reith V., Rempe H., Schoene D., Sieber G., Zielinski K., Anker S. D., Ebner N., Grutz R., von Haehling S., Schols A. M. W. J., Gosker H., Huysmans S., Quaaden S., Schols J. M., Smeets N., Stevens P., van de Bool C., Weling C., Strandberg T., Jyvakorpi S., Hallikas K., Herranen M., Huusko T., Hytonen L., Ikonen K., Karppi-Sjoblom A., Karvinen K., Kayhty M., Kindsted T., Landstrom E., Leirimaa S., Pitkala K., Punkka A., Saavalainen A. -M., Salo T., Sepa M., Sohlberg K., Vaatamoinen E., Venalainen S., Vanhanen H., Vellas B., Van Kan G. A., Biville V., Brigitte L., Cervera C., Cesari M., Champarnaud M., Cluzan C., Croizet M., Dardenne S., Dorard M., Dupuy C., Durand E., Faisant C., Fougere B., Girard P., Guyonnet S., Hoogendijk E., Mauroux R., Milhet A., Montel S., Ousset P. -J., Teguo M. T., Teysseyre B., Andrieu S., Blasimme A., Dray C., Rial-Sebbag E., Valet P., Dantoine T., Cardinaud N., Castelli M., Charenton-Blavignac M., Ciccolari-Micaldi C., Gayot C., Laubarie-Mouriet C., Marchesseau D., Mergans T., Nguyen T. B., Papon A., Ribet J., Saulinier I., Tchalla A., Rapp T., Sirven N., Skalska A., Blaszcyk E., Cwynar M., Czesak J., Fatyga P., Fedyk-Lukasik M., Grodzicki T., Jamrozik P., Janusz Z., Klimek E., Komoniewska S., Kret M., Ozog M., Parnicka A., Petitjean K., Pietrzyk A., Skalska-Dulinska B., Starzyk D., Szczerbinska K., Witkiewicz B., Wlodarczyk A., Sinclair A., Harris S., Ogborne A., Ritchie S., Sinclair C., Sinclair H., Bellary S., Worthington H., Derejczyk J., Roller-Wirnsberger R., Jonsson P., Bordes P., Arnaud S., Asbrand C., Bejuit R., Durand S., Flechsenhar K., Joly F., Lain R. L., Moncharmont M., Msihid J., Ndja A., Riche B., Weber A. C., Yuan J., Roubenoff R., Kortebein P., Miller R. R., Gorostiaga C., Belissa-Mathiot P., Hu H., Laigle L., Melchor I. M., Russel A., Bennecky M., Haws T., Joshi A., Philpott K., Walker A., Zia G., Giorgi S. D., Feletti L., Marchioro E., Mocci F., Varesio M. G., Cesario A., Cabin B., de Boer W. P., Ignaszewski C., Klingmann I., Vollenbroek-Hutten M., Hermens T., Jansen-Kosterink S., Tabak M., Blandin P., Coutard L., Lenzotti A. -M., Mokhtari H., Rodon N., RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: CAPHRI - R1 - Ageing and Long-Term Care, Health Services Research, Handicap, Activité, Vieillissement, Autonomie, Environnement (HAVAE), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Clinicum, Department of General Practice and Primary Health Care, University of Helsinki, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, Helsinki University Hospital Area, Teachers' Academy, Jyvakorpi S.K., Ramel A., Strandberg T.E., Piotrowicz K., Blaszczyk-Bebenek E., Urtamo A., Rempe H.M., Geirsdottir O., Vagnerova T., Billot M., Larreur A., Savera G., Soriano G., Picauron C., Tagliaferri S., Sanchez-Puelles C., Cadenas V.S., Perl A., Tirrel L., Ohman H., Weling-Scheepers C., Ambrosi S., Costantini A., Pavelkova K., Klimkova M., Freiberger E., Jonsson P.V., Marzetti E., Pitkala K.H., Landi F., Calvani R., Bernabei R., Boni C., Brandi V., Broccatelli M., Celesti C., Cicchetti A., Collamati A., Coretti S., D'Angelo E., D'Elia M., Landi G., Lorenzi M., Mariotti L., Martone A.M., Ortolani E., Pafundi T., Picca A., Ruggeri M., Salini S., Tosato M., Vetrano D.L., Lattanzio F., Baldoni R., Bernabei S., Bonfigli A.R., Bustacchini S., Carrieri B., Cassetta L., Cherubini A., Cucchi M., Cucchieri G., Costantini A.R., Dell'Aquila G., Espinosa E., Fedecostante M., Fraternali R., Galeazzi R., Mengarelli A., Piomboni S., Posacki E., Severini E., Tregambe T., Trotta F., Maggio M., Lauretani F., Butto V., Fisichella A., Guareschi C., Longobucco Y., Di Bari M., Rodriguez-Manas L., Alamo S., Bouzon C.A., Gonzales Turin J., Zafra O.L.L., Picazo A.L., Sepulveda L.P., SanchezSanchez J.L., Puelles C.S., Aragones M.V., CruzJentoft A.J., Santos J.A., Alvarez-Nebreda L., JimenezJimenez N.F., Nozal J.M.-D., Montero-Errasquin B., Moreno B.P.B.P., Roldan-Plaza C., Vicente A.R.-D., Sanchez-Cadenas V., Sanchez-Castellano C., Sanchez-Garcia E., Vaquero-Pinto M.N., Topinkova E., Bautzka L., Blechova K., Gueye T., Juklickova I., Klbikova T., Krenkova J.J., Madlova P., Mejstrikova H., Melcova R., Michalkova H., Ryznarova I., Drastichova I., Hasalikova E., Hucko R., Jakub S., Janacova M., Kilmkova M., Parizkova M., Redrova M., Ruskova P.P., Sieber C.C., Auerswald T., Engel C., Franke A., Freibergen E., Freiheit U., Gotthardt S., Kampe K., Kob R., Kokott C., Kraska C., Meyer C., Reith V., Rempe H., Schoene D., Sieber G., Zielinski K., Anker S.D., Ebner N., Grutz R., von Haehling S., Schols A.M.W.J., Gosker H., Huysmans S., Quaaden S., Schols J.M., Smeets N., Stevens P., van de Bool C., Weling C., Strandberg T., Jyvakorpi S., Hallikas K., Herranen M., Huusko T., Hytonen L., Ikonen K., Karppi-Sjoblom A., Karvinen K., Kayhty M., Kindsted T., Landstrom E., Leirimaa S., Pitkala K., Punkka A., Saavalainen A.-M., Salo T., Sepa M., Sohlberg K., Vaatamoinen E., Venalainen S., Vanhanen H., Vellas B., Van Kan G.A., Biville V., Brigitte L., Cervera C., Cesari M., Champarnaud M., Cluzan C., Croizet M., Dardenne S., Dorard M., Dupuy C., Durand E., Faisant C., Fougere B., Girard P., Guyonnet S., Hoogendijk E., Mauroux R., Milhet A., Montel S., Ousset P.-J., Teguo M.T., Teysseyre B., Andrieu S., Blasimme A., Dray C., Rial-Sebbag E., Valet P., Dantoine T., Cardinaud N., Castelli M., Charenton-Blavignac M., Ciccolari-Micaldi C., Gayot C., Laubarie-Mouriet C., Marchesseau D., Mergans T., Nguyen T.B., Papon A., Ribet J., Saulinier I., Tchalla A., Rapp T., Sirven N., Skalska A., Blaszcyk E., Cwynar M., Czesak J., Fatyga P., Fedyk-Lukasik M., Grodzicki T., Jamrozik P., Janusz Z., Klimek E., Komoniewska S., Kret M., Ozog M., Parnicka A., Petitjean K., Pietrzyk A., Skalska-Dulinska B., Starzyk D., Szczerbinska K., Witkiewicz B., Wlodarczyk A., Sinclair A., Harris S., Ogborne A., Ritchie S., Sinclair C., Sinclair H., Bellary S., Worthington H., Derejczyk J., Roller-Wirnsberger R., Jonsson P., Bordes P., Arnaud S., Asbrand C., Bejuit R., Durand S., Flechsenhar K., Joly F., Lain R.L., Moncharmont M., Msihid J., Ndja A., Riche B., Weber A.C., Yuan J., Roubenoff R., Kortebein P., Miller R.R., Gorostiaga C., Belissa-Mathiot P., Hu H., Laigle L., Melchor I.M., Russel A., Bennecky M., Haws T., Joshi A., Philpott K., Walker A., Zia G., Giorgi S.D., Feletti L., Marchioro E., Mocci F., Varesio M.G., Cesario A., Cabin B., de Boer W.P., Ignaszewski C., Klingmann I., Vollenbroek-Hutten M., Hermens T., Jansen-Kosterink S., Tabak M., Blandin P., Coutard L., Lenzotti A.-M., Mokhtari H., Rodon N., Epidemiology and Data Science, APH - Aging & Later Life, and APH - Quality of Care

Subjects
0301 basic medicine, Gerontology, Sarcopenia, [SDV]Life Sciences [q-bio], Population, PROTEIN, RECOMMENDATIONS, law.invention, SUPPLEMENTATION, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Intervention (counseling), Cultural diversity, medicine, Nutrition counselling, Nutrition intervention, Humans, 030212 general & internal medicine, Medical prescription, education, Exercise, Aged, 2. Zero hunger, education.field_of_study, 030109 nutrition & dietetics, Frailty, business.industry, Settore MED/09 - MEDICINA INTERNA, ADULTS, medicine.disease, mobility, 3. Good health, Feasibility Studie, Malnutrition, SPRINTT, resistance exercise, muscle mass, Protein intake, 3121 General medicine, internal medicine and other clinical medicine, Feasibility Studies, Energy intake, Independent Living, business, Nutrition counseling, Research Paper, Human
Abstract

Aim To describe the methods and feasibility of the nutritional intervention carried out within the SPRINTT Randomized cotrolled trial. We also illustrate how nutrition interventionists identified participants at risk of malnutrition and the lessons learnt from the nutrition intervention. Findings SPRINTT nutrition intervention was well-received by the majority of the participants. It was mainly carried out using tailored nutrition counselling, but also other means of delivering the intervention were successfully used. Compared with a standard nutrition prescription, an individualized protocol to diagnose malnutrition and follow-up by tailored nutrition counselling helped achieve nutritional targets more effectively in spite of diversity of population in nutritional habits and in some cases reluctance to accept changes. Message The SPRINTT nutrition intervention was feasible and allowed flexibility to the varying needs and cultural differences of this heterogeneous population of frail, older Europeans. It may serve as a model to educate and improve nutrition among community-dwelling older people at risk of mobility limitations. Supplementary Information The online version contains supplementary material available at 10.1007/s41999-020-00438-4., Background The “Sarcopenia and Physical Frailty in Older People: Multicomponent Treatment Strategies” (SPRINTT) project sponsored a multi-center randomized controlled trial (RCT) with the objective to determine the effect of physical activity and nutrition intervention for prevention of mobility disability in community-dwelling frail older Europeans. We describe here the design and feasibility of the SPRINTT nutrition intervention, including techniques used by nutrition interventionists to identify those at risk of malnutrition and to carry out the nutrition intervention. Methods SPRINTT RCT recruited older adults (≥ 70 years) from 11 European countries. Eligible participants (n = 1517) had functional limitations measured with Short Physical Performance Battery (SPPB score 3–9) and low muscle mass as determined by DXA scans, but were able to walk 400 m without assistance within 15 min. Participants were followed up for up to 3 years. The nutrition intervention was carried out mainly by individual nutrition counseling. Nutrition goals included achieving a daily protein intake of 1.0–1.2 g/kg body weight, energy intake of 25–30 kcal/kg of body weight/day, and serum vitamin D concentration ≥ 75 mmol/L. Survey on the method strategies and feasibility of the nutrition intervention was sent to all nutrition interventionists of the 16 SPRINTT study sites. Results Nutrition interventionists from all study sites responded to the survey. All responders found that the SPRINTT nutrition intervention was feasible for the target population, and it was well received by the majority. The identification of participants at nutritional risk was accomplished by combining information from interviews, questionnaires, clinical and laboratory data. Although the nutrition intervention was mainly carried out using individual nutritional counselling, other assisting methods were used as appropriate. Conclusion The SPRINTT nutrition intervention was feasible and able to adapt flexibly to varying needs of this heterogeneous population. The procedures adopted to identify older adults at risk of malnutrition and to design the appropriate intervention may serve as a model to deliver nutrition intervention for community-dwelling older people with mobility limitations. Supplementary Information The online version contains supplementary material available at 10.1007/s41999-020-00438-4.

Published
2021

9. The sarcopenia and physical frailty in older people: multi-component treatment strategies (SPRINTT) project:description and feasibility of a nutrition intervention in community-dwelling older Europeans

Author

Jyvakorpi, S. K. (S. K.), Ramel, A. (A.), Strandberg, T. E. (T. E.), Piotrowicz, K. (K.), Blaszczyk-Bebenek, E. (E.), Urtamo, A. (A.), Rempe, H. M. (H. M.), Geirsdottir, O. (O.), Vagnerova, T. (T.), Billot, M. (M.), Larreur, A. (A.), Savera, G. (G.), Soriano, G. (G.), Picauron, C. (C.), Tagliaferri, S. (S.), Sanchez-Puelles, C. (C.), Cadenas, V. S. (V. Sanchez), Perl, A. (A.), Tirrel, L. (L.), Ohman, H. (H.), Weling-Scheepers, C. (C.), Ambrosi, S. (S.), Costantini, A. (A.), Pavelkova, K. (K.), Klimkova, M. (M.), Freiberger, E. (E.), Jonsson, P. V. (P., V), Marzetti, E. (E.), Pitkala, K. H. (K. H.), Landi, F. (F.), and Calvani, R. (R.)

Subjects
SPRINTT, Protein intake, Nutrition counselling, Nutrition intervention, Energy intake
Abstract

Background: The “Sarcopenia and Physical Frailty in Older People: Multicomponent Treatment Strategies” (SPRINTT) project sponsored a multi-center randomized controlled trial (RCT) with the objective to determine the effect of physical activity and nutrition intervention for prevention of mobility disability in community-dwelling frail older Europeans. We describe here the design and feasibility of the SPRINTT nutrition intervention, including techniques used by nutrition interventionists to identify those at risk of malnutrition and to carry out the nutrition intervention. Methods: SPRINTT RCT recruited older adults (≥ 70 years) from 11 European countries. Eligible participants (n = 1517) had functional limitations measured with Short Physical Performance Battery (SPPB score 3–9) and low muscle mass as determined by DXA scans, but were able to walk 400 m without assistance within 15 min. Participants were followed up for up to 3 years. The nutrition intervention was carried out mainly by individual nutrition counseling. Nutrition goals included achieving a daily protein intake of 1.0–1.2 g/kg body weight, energy intake of 25–30 kcal/kg of body weight/day, and serum vitamin D concentration ≥ 75 mmol/L. Survey on the method strategies and feasibility of the nutrition intervention was sent to all nutrition interventionists of the 16 SPRINTT study sites. Results: Nutrition interventionists from all study sites responded to the survey. All responders found that the SPRINTT nutrition intervention was feasible for the target population, and it was well received by the majority. The identification of participants at nutritional risk was accomplished by combining information from interviews, questionnaires, clinical and laboratory data. Although the nutrition intervention was mainly carried out using individual nutritional counselling, other assisting methods were used as appropriate. Conclusion: The SPRINTT nutrition intervention was feasible and able to adapt flexibly to varying needs of this heterogeneous population. The procedures adopted to identify older adults at risk of malnutrition and to design the appropriate intervention may serve as a model to deliver nutrition intervention for community-dwelling older people with mobility limitations.

Published
2021

10. Age-related alterations in muscle architecture are a signature of sarcopenia: the ultrasound sarcopenia index

Author

Narici, M, McPhee, J, Conte, M, Franchi, MV, Mitchell, K, Tagliaferri, S, Monti, E, Marcolin, G, Atherton, PJ, Smith, K, Phillips, B, Lund, J, Franceschi, C, Maggio, M, Butler-Browne, GS, Narici, M, McPhee, J, Conte, M, Franchi, MV, Mitchell, K, Tagliaferri, S, Monti, E, Marcolin, G, Atherton, PJ, Smith, K, Phillips, B, Lund, J, Franceschi, C, Maggio, M, and Butler-Browne, GS

Abstract

Background: The assessment of muscle mass is a key determinant of the diagnosis of sarcopenia. We introduce for the first time an ultrasound imaging method for diagnosing sarcopenia based on changes in muscle geometric proportions. Methods: Vastus lateralis muscle fascicle length (Lf) and thickness (Tm) were measured at 35% distal femur length by ultrasonography in a population of 279 individuals classified as moderately active elderly (MAE), sedentary elderly (SE) (n = 109), mobility impaired elderly (MIE) (n = 43), and in adult young controls (YC) (n = 60). The ratio of Lf/Tm was calculated to obtain an ultrasound index of the loss of muscle mass associated with sarcopenia (USI). In a subsample of elderly male individuals (n = 76) in which corresponding DXA measurements were available (MAE, n = 52 and SE, n = 24), DXA-derived skeletal muscle index (SMI, appendicular limb mass/height2) was compared with corresponding USI values. Results: For both young and older participants, USI values were found to be independent of sex, height and body mass. USI values were 3.70 ± 0.52 for YC, 4.50 ± 0.72 for the MAE, 5.05 ± 1.11 for the SE and 6.31 ± 1.38 for the MIE, all significantly different between each other (P < 0.0001). Based on the USI Z-scores, with reference to the YC population, the 219 elderly participants were stratified according to their muscle sarcopenic status. Individuals with USI values within a range of 3.70 < USI ≥ 4.23 were classified as non-sarcopenic (prevalence 23.7%), those with USI values within 4.23 < USI ≥ 4.76 were classified as pre-sarcopenic (prevalence 23.7%), those with USI values within 4.76 < USI ≥ 5.29 were classified as moderately sarcopenic (prevalence 15.1%), those with USI values within range 5.29 < USI ≥ 5.82 were classified as sarcopenic (prevalence 27.9%), and those with USI values >5.82 were classified as severely sarcopenic (prevalence 9.6%). The DXA-derived SMI was found to be significantly correlated with USI (r = 0.61, P < 0.000

Published
2021

11. The sarcopenia and physical frailty in older people: multi-component treatment strategies (SPRINTT) project: description and feasibility of a nutrition intervention in community-dwelling older Europeans

Author

Jyväkorpi, S K, Ramel, A, Strandberg, T E, Piotrowicz, K, Błaszczyk-Bębenek, E, Urtamo, A, Rempe, H M, Geirsdóttir, Ó, Vágnerová, T, Billot, M, Larreur, A, Savera, Giulia, Soriano, G, Picauron, C, Tagliaferri, S, Sanchez-Puelles, C, Cadenas, V Sánchez, Perl, A, Tirrel, L, Öhman, H, Weling-Scheepers, C, Ambrosi, S, Costantini, A, Pavelková, K, Klimkova, M, Freiberger, E, Jonsson, P V, Marzetti, Emanuele, Pitkälä, K H, Landi, Francesco, Calvani, Riccardo, Savera, G, Marzetti, E (ORCID:0000-0001-9567-6983), Landi, F (ORCID:0000-0002-3472-1389), Calvani, R (ORCID:0000-0001-5472-2365), Jyväkorpi, S K, Ramel, A, Strandberg, T E, Piotrowicz, K, Błaszczyk-Bębenek, E, Urtamo, A, Rempe, H M, Geirsdóttir, Ó, Vágnerová, T, Billot, M, Larreur, A, Savera, Giulia, Soriano, G, Picauron, C, Tagliaferri, S, Sanchez-Puelles, C, Cadenas, V Sánchez, Perl, A, Tirrel, L, Öhman, H, Weling-Scheepers, C, Ambrosi, S, Costantini, A, Pavelková, K, Klimkova, M, Freiberger, E, Jonsson, P V, Marzetti, Emanuele, Pitkälä, K H, Landi, Francesco, Calvani, Riccardo, Savera, G, Marzetti, E (ORCID:0000-0001-9567-6983), Landi, F (ORCID:0000-0002-3472-1389), and Calvani, R (ORCID:0000-0001-5472-2365)

Abstract

Background The "Sarcopenia and Physical Frailty in Older People: Multicomponent Treatment Strategies" (SPRINTT) project sponsored a multi-center randomized controlled trial (RCT) with the objective to determine the effect of physical activity and nutrition intervention for prevention of mobility disability in community-dwelling frail older Europeans. We describe here the design and feasibility of the SPRINTT nutrition intervention, including techniques used by nutrition interventionists to identify those at risk of malnutrition and to carry out the nutrition intervention. Methods SPRINTT RCT recruited older adults (>= 70 years) from 11 European countries. Eligible participants (n = 1517) had functional limitations measured with Short Physical Performance Battery (SPPB score 3-9) and low muscle mass as determined by DXA scans, but were able to walk 400 m without assistance within 15 min. Participants were followed up for up to 3 years. The nutrition intervention was carried out mainly by individual nutrition counseling. Nutrition goals included achieving a daily protein intake of 1.0-1.2 g/kg body weight, energy intake of 25-30 kcal/kg of body weight/day, and serum vitamin D concentration >= 75 mmol/L. Survey on the method strategies and feasibility of the nutrition intervention was sent to all nutrition interventionists of the 16 SPRINTT study sites. Results Nutrition interventionists from all study sites responded to the survey. All responders found that the SPRINTT nutrition intervention was feasible for the target population, and it was well received by the majority. The identification of participants at nutritional risk was accomplished by combining information from interviews, questionnaires, clinical and laboratory data. Although the nutrition intervention was mainly carried out using individual nutritional counselling, other assisting methods were used as appropriate. Conclusion The SPRINTT nutrition intervention was feasible and able to adapt flexibly

Published
2021

16. A NOVEL TOOL FOR THE EARLY IDENTIFICATION OF FRAILTY IN ELDERLY PEOPLE: THE APPLICATION IN PRIMARY CARE SETTINGS

Author

Maggio, M., primary, Barbolini, M., additional, Longobucco, Y., additional, Barbieri, L., additional, Benedetti, C., additional, Bono, F., additional, Cacciapuoti, I., additional, Donatini, A., additional, Iezzi, E., additional, Papini, D., additional, Rodelli, P.M., additional, Tagliaferri, S., additional, and Moro, M.L., additional

Published
2019
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23. The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 {alpha} (HIF-1{alpha}) activity: involvement in myeloma-induced angioge

Author

Colla, S, Tagliaferri, S, Morandi, F, Lunghi, P, Donofrio, G, Martorana, D, Mancini, C, Lazzaretti, M, Mazzera, L, Ravanetti, L, Bonomini, S, Ferrari, L, Miranda, C, Ladetto, Marco, Neri, Tm, Neri, A, Greco, A, Mangoni, M, Bonati, A, Rizzoli, V, and Giuliani, N.

Published
2007

24. IUGR Management: New Perspectives

Author

Giuliano, N., primary, Annunziata, M. L., additional, Tagliaferri, S., additional, Esposito, F. G., additional, Imperato, O. C. M., additional, Campanile, M., additional, Signorini, M. G., additional, and Di Lieto, A., additional

Published
2014
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27. Phomopsins: an overview of phytopathological and chemical aspects, toxicity, analysis and occurrence

Author

Battilani, P., primary, Gualla, A., additional, Dall'Asta, C., additional, Pellacani, C., additional, Galaverna, G., additional, Giorni, P., additional, Caglieri, A., additional, Tagliaferri, S., additional, Pietri, A., additional, Dossena, A., additional, Spadaro, D., additional, Marchelli, R., additional, Gullino, M., additional, and Costa, L., additional

Published
2011
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29. Synergistic interactions between PBDEs and PCBs in human neuroblastoma cells.

Author

Pellacani, C., Tagliaferri, S., Caglieri, A., Goldoni, M., Giordano, G., Mutti, A., and Costa, L. G.

Subjects
POLYBROMINATED diphenyl ethers, POLYCHLORINATED biphenyls, NEUROBLASTOMA, POLLUTANTS, NEUROTOXICOLOGY
Abstract

Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants. Exposure to these chemicals has been associated with developmental neurotoxicity, endocrine dysfunction, and reproductive disorders. Humans and wildlife are generally exposed to a mixture of these environmental pollutants, highlighting the need to evaluate the potential effects of combined exposures. In this study, we investigated the cytotoxic effects of the combined exposure to two PBDEs and two PCBs in a human neuronal cell line. 2,2′,4,4′-Tetrabromodiphenyl ether, 2,2′,4,4′,5-pentabromodiphenyl ether, PCB-126 (3,3′,4,4′,5-pentachlorobiphenyl; a dioxin-like PCB), and PCB-153 (2,2′,4,4′,5,5′-hexachlorobiphenyl; a non-dioxin-like PCB) were chosen, because their concentrations are among the highest in human tissues and the environment. The results suggest that the nature of interactions is related to the PCB structure. Mixtures of PCB-153 and both PBDEs had a prevalently synergistic effect. In contrast, mixtures of each PBDE congener with PCB-126 showed additive effects at threshold concentrations, and synergistic effects at higher concentrations. These results emphasize the concept that the toxicity of xenobiotics may be affected by possible interactions, which may be of significance given the common coexposures to multiple contaminants. [ABSTRACT FROM AUTHOR]

Published
2014
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32. Behavior of Non-Promoted and Ceria-Promoted Pt/Rh and Pd/Rh Three-Way Catalysts under Steady State and Dynamic Operation of Hybrid Vehicles

Author

Tagliaferri, S., Koppel, R. A., and Baiker, A.

Abstract

The suitability of newly developed non-promoted and ceria-promoted palladium−rhodium automotive catalysts for the exhaust gas control of a hybrid drive system has been tested by light-off experiments with steady and cycling feed stoichiometry, and pulsed-flow operation. The dynamic behavior of the honeycomb-type catalysts has been compared to the performance of standard honeycomb platinum−rhodium catalysts. Light-off tests carried out in the range 150−500 °C indicated significant differences in the conversion of NOx, CO, and hydrocarbons during warm-up, depending on the catalyst composition and whether λ-cycling was applied or not. Appropriate λ-cycling substantially improved the behavior of all catalysts in the lower light-off region. At higher temperatures cycling afforded lower conversions of all target components. Under pulsed-flow operation with an air pulse preceding the exhaust pulse (filling of the cylinder with air), asymmetric λ-cycling with longer rich half-cycles resulted in CO and HC conversions as well as N2 yields similar to or higher than those without an air pulse for the ceria-promoted catalysts. The catalytic tests suggest that ceria-promoted palladium is competitive to Pt−Rh−Ce in a hybrid vehicle application.

Published
1999

33. Automatic and Noninvasive Indoor Air Quality Control in HVAC Systems

Author

C. Basile, M., Bruni, V., Buccolini, F., De Canditiis, D., Tagliaferri, S., and Vitulano, D.

Abstract

This paper presents a methodology for assessing and monitoring the cleaning state of a heating, ventilation, and air conditioning (HVAC) system of a building. It consists of a noninvasive method for measuring the amount of dust in the whole ventilation system, that is, the set of filters and air ducts. Specifically, it defines the minimum amount of measurements, their time table, locations, and acquisition conditions. The proposed method promotes early intervention on the system and it guarantees high indoor air quality and proper HVAC working conditions. The effectiveness of the method is proved by some experimental results on different study cases.

Published
2016
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35. Placental dysfunction in uncomplicated and complicated intrauterine growth restriction by preeclampsia and neonatal outcome

Author

Alessandra Ammendola, Marta Campanile, Antonio Raffone, Fulvio Zullo, Salvatore Tagliaferri, Nicolò Pini, Gabriele Saccone, Maurizio Guida, Antonio Travaglino, Maria D'Armiento, Maria Raffaela Campanino, Giuseppe Zara, Maria G. Signorini, Giuseppe Maria Maruotti, Giovanni Magenes, Tagliaferri, S., Travaglino, A., Raffone, A., Saccone, G., Campanino, M. R., Zara, G., Ammendola, A., Pini, N., Maruotti, G. M., Magenes, G., Signorini, M. G., Guida, M., Zullo, F., D'Armiento, M., and Campanile, M.

Subjects
medicine.medical_specialty, intrauterine growth restriction, Cardiotocography, Placenta, Birth weight, placental histological abnormalities, Intrauterine growth restriction, neonatal outcome, Preeclampsia, Pre-Eclampsia, Pregnancy, Placental dysfunction, Internal medicine, Clinical endpoint, Humans, Medicine, Pathological, Retrospective Studies, Fetal Growth Retardation, business.industry, Infant, Newborn, Obstetrics and Gynecology, Heart Rate, Fetal, medicine.disease, placental histological abnormalitie, Fetal heart monitoring, Case-Control Studies, embryonic structures, Pediatrics, Perinatology and Child Health, Cardiology, Female, Base excess, business, Complication
Abstract

To investigate the use of computerized cardiotocography (cCTG) parameters in Intrauterine Growth Restriction (IUGR) pregnancies for the prediction of 1) complication with preeclampsia; 2) placental histological abnormalities, and 3) neonatal outcomes. A single-center observational retrospective case-control study was performed by reviewing medical records, cCTG databases and pathological reports of women with singleton pregnancy and IUGR uncomplicated (controls) and complicated by preeclampsia (cases). Primary endpoint was the association between cCTG parameters and preeclampsia in IUGR. Secondary endpoints were the association between cCTG parameters and 1) placental abnormalities, and 2) neonatal outcomes. The one-way ANOVA test was used to compare cCTG parameters in cases and controls. t-test was applied to compare neonatal outcomes and placental abnormalities in both groups. The Spearman Test value Correlation coefficients between the cCTG parameters and neonatal outcome in the two groups. A p value < .05 was considered significant for all analyses. Among all cCTG parameters, a significant association with preeclampsia in IUGR was found for Fetal Heart Rate (FHR, p = .008), Delta (p = .018), Short Term Variability (STV, p = .021), Long Term Variability (LTV, p = .028), Acceleration Phase Rectified Slope (APRS, p = .018) and Deceleration Phase Rectified Slope (DPRS, p = .038). Of all placental histologic abnormalities, only vascular alterations at least moderate were significantly associated with increased FHR (p = .02). About neonatal outcomes, all cCTG parameters were significantly associated with birth weight, Apgar index at 1 and 5 min, pH and pCO2. FHR, LTI, Delta, Approximate Entropy (ApEn) and LF were significantly associated with pO2; LTI, Interval Index (II) and ApEn with base excess. Among controls, Delta, ApEn, Low Frequency (LF) and High Frequency (HF) were significantly associated with pCO2, while among cases, STV and Delta were significantly associated with pH; STV, LTI, Delta, ApEn, LF and HF with pCO2; STV, LTI, Delta and ApEn with pO2; HF with base excess; FHR and LF with lactates. cCTG parameters may be useful to detect complication with preeclampsia in IUGR pregnancies. Regarding placental status, cCTG parameters may detect overall circulation alterations, but not specific histological abnormalities. Lastly, all cCTG parameters may predict neonatal outcomes, helping to tailor the patients’ management.

Published
2021

36. Maternal haemodynamic profile in pregnancy after assisted reproductive technology: A pilot study

Author

Marta Campanile, Farid Talhami, Salvatore Tagliaferri, Laura Sarno, Maurizio Guida, Sonia Migliorini, Annunziata Carlea, Giuseppe Maria Maruotti, Sarno, L., Tagliaferri, S., Carlea, A., Talhami, F., Migliorini, S., Maruotti, G. M., Campanile, M., and Guida, M.

Subjects
Cardiac output, Adult, medicine.medical_specialty, Reproductive Techniques, Assisted, Systemic vascular resistance, medicine.medical_treatment, Hemodynamics, Pilot Projects, Pregnancy outcome, Pregnancy, Internal Medicine, medicine, Humans, Pilot Project, Prospective Studies, Hemodynamic, Assisted reproductive technology, Obstetrics, Singleton, Obstetric examination, business.industry, Maternal haemodynamic, Obstetrics and Gynecology, medicine.disease, Prospective Studie, medicine.anatomical_structure, Increased risk, Case-Control Studies, Vascular resistance, Female, Case-Control Studie, business, Human
Abstract

Singleton pregnancies obtained by assisted reproductive technology (ART) are at increased risk of adverse pregnancy outcome. Aim of this pilot study was to compare maternal hemodynamic profile in ART and spontaneous singleton pregnancies. Patients were enrollered during a third trimester routine obstetric examination. Maternal haemodynamic assessment was carried out by a single trained operator using an UltraSonic Cardiac Output Monitor in standardized conditions. Our pilot data suggests that women conceived after ART may have significantly lower Cardiac Output and significantly higher Systemic Vascular Resistance when compared to those conceiving spontaneously. These differences, if confirmed in larger studies, might explain the increased prevalence of adverse outcome, especially hypertensive disorders of pregnancy, in singleton ART pregnancies.

Published
2021

37. miR-16-5p, miR-103-3p, and miR-27b-3p as Early Peripheral Biomarkers of Fetal Growth Restriction

Author

Salvatore Tagliaferri, Pasquale Cepparulo, Antonio Vinciguerra, Marta Campanile, Giuseppina Esposito, Giuseppe Maria Maruotti, Fulvio Zullo, Lucio Annunziato, Giuseppe Pignataro, Tagliaferri, S., Cepparulo, P., Vinciguerra, A., Campanile, M., Esposito, G., Maruotti, G. M., Zullo, F., Annunziato, L., and Pignataro, G.

Subjects
Disease, Pediatrics, Andrology, fetal growth restriction, 03 medical and health sciences, 0302 clinical medicine, Placenta, medicine, Pregnancy, Fetus, 030219 obstetrics & reproductive medicine, microRNA, business.industry, hypoxia, lcsh:RJ1-570, biomarkers, Gestational age, lcsh:Pediatrics, Brief Research Report, Hypoxia (medical), medicine.disease, FGR, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Gestation, Population study, biomarker, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

Current tests available to diagnose fetal hypoxia in-utero lack sensitivity thus failing to identify many fetuses at risk. Emerging evidence suggests that microRNAs derived from the placenta circulate in the maternal blood during pregnancy and may be used as non-invasive biomarkers for pregnancy complications. With the intent to identify putative markers of fetal growth restriction (FGR) and new therapeutic druggable targets, we examined, in maternal blood samples, the expression of a group of microRNAs, known to be regulated by hypoxia. The expression of microRNAs was evaluated in maternal plasma samples collected from (1) women carrying a preterm FGR fetus (FGR group) or (2) women with an appropriately grown fetus matched at the same gestational age (Control group). To discriminate between early- and late-onset FGR, the study population was divided into two subgroups according to the gestational age at delivery. Four microRNAs were identified as possible candidates for the diagnosis of FGR: miR-16-5p, miR-103-3p, miR-107-3p, and miR-27b-3p. All four selected miRNAs, measured by RT-PCR, resulted upregulated in FGR blood samples before the 32nd week of gestation. By contrast, miRNA103-3p and miRNA107-3p, analyzed between the 32nd and 37th week of gestation, showed lower expression in the FGR group compared to aged matched controls. Our results showed that measurement of miRNAs in maternal blood may form the basis for a future diagnostic test to determine the degree of fetal hypoxia in FGR, thus allowing the start of appropriate therapeutic interventions to alleviate the burden of this disease.

Published
2021

38. Treatment of Delirium in Older Persons: What We Should Not Do!

Author

Giovanna Pelà, Sara Tagliaferri, Giuseppe Bellelli, Marcello Maggio, Fulvio Lauretani, S. Morganti, Lauretani, F, Bellelli, G, Pela, G, Morganti, S, Tagliaferri, S, and Maggio, M

Subjects
medicine.medical_specialty, media_common.quotation_subject, Review, Catalysis, Pharmacological treatment, Inorganic Chemistry, lcsh:Chemistry, 03 medical and health sciences, 0302 clinical medicine, delirium, pharmacological treatment, Orientation (mental), Perception, Cerebral function, Medicine, Humans, Cognitive Dysfunction, 030212 general & internal medicine, Physical and Theoretical Chemistry, Intensive care medicine, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, Brain function, media_common, Balance (ability), older person, Psychotropic Drugs, business.industry, Organic Chemistry, Stressor, General Medicine, Computer Science Applications, Hospitalization, neurogeriatric disorders, lcsh:Biology (General), lcsh:QD1-999, Acute Disease, older persons, Delirium, neurogeriatric disorder, medicine.symptom, business, Cognition Disorders, 030217 neurology & neurosurgery
Abstract

The presentation of common acute diseases in older age is often referred to as “atypical”. Frequently, the symptoms are neither single nor tissue related. In most cases, the onset of symptoms and diseases is the expression of a diminished reserve with a failure of the body system and imbalance of brain function. Delirium is one of the main devastating and prevalent atypical symptoms and could be considered as a geriatric syndrome. It encompasses an array of neuropsychiatric symptoms and represents a disarrangement of the cerebral function in response to one or more stressors. The most recent definition, reported in the DSM-V, depicts delirium as a clear disturbance in attention and awareness. The deficit is to be developed in a relatively short time period (usually hours or days). The attention disorder must be associated with another cognitive impairment in memory, orientation, language, visual-spatial or perception abilities. For the treatment, it is imperative to remove the potential causes of delirium before prescribing drugs. Even a non-pharmacological approach to reducing the precipitating causes should be identified and planned. When we are forced to approach the pharmacological treatment of hyperactive delirium in older persons, we should select highly cost-effective drugs. High attention should be devoted to the correct balance between improvement of psychiatric symptoms and occurrence of side effects. Clinicians should be guided in the correct choice of drugs following cluster symptoms presentation, excluding drugs that could potentially produce complications rather than advantages. In this brief point-of-view, we propose a novel pharmacological flow-chart of treatment in relation to the basic clusters of diseases of an older patient acutely admitted to the hospital and, in particular, we emphasize “What We Should Not Do!”, with the intention of avoiding possible side effects of drugs used.

Published
2020

39. Deinococcus radiodurans' SRA-HNH domain containing protein Shp (Dr1533) is involved in faithful genome inheritance maintenance following DNA damage

Author

Mauro Pitaro, Suzanne Sommer, Federica Castani, Alex Ferrandi, Paola Barbieri, Monica Mancini, Sara Tagliaferri, Rosa Alduina, Claire Bouthier de la Tour, Ian Marc Bonapace, Mauro Fasano, Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Radiorésistance des bactéries et des archées (RBA), Département Biologie des Génomes (DBG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Biologia Strutturale e Funzionale, Universitá degli Studi dell’Insubria = University of Insubria [Varese] (Uninsubria), Department of Structural and Functional Biology, Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Universitá degli Studi dell’Insubria, and Ferrandi A, Castani F, Pitaro M, Tagliaferri S, de la Tour CB, Alduina R, Sommer S, Fasano M, Barbieri P, Mancini M, Bonapace IM.

Subjects
DNA Repair, DNA cytosine-methylation, DNA damage, DR1533 locus, Genotoxic agents, Mn2+, SRA domain, Biophysics, Biochemistry, Molecular Biology, [SDV]Life Sciences [q-bio], perspective, Settore BIO/19 - Microbiologia Generale, chemistry.chemical_compound, 0302 clinical medicine, Kanamycin, Cloning, Molecular, cytosine, 0303 health sciences, biology, Chemistry, Genotoxic agent, uhrf1, Mn(2+), Deinococcus, recognition, manganese(ii), DNA, Bacterial, DNA repair, oxidation, Ubiquitin-Protein Ligases, Settore BIO/11 - Biologia Molecolare, resistance, 03 medical and health sciences, Bacterial Proteins, Protein Domains, DR1533 locu, Drug Resistance, Bacterial, Escherichia coli, Humans, features, Amino Acid Sequence, Gene, 030304 developmental biology, Oligonucleotide, Computational Biology, Deinococcus radiodurans, DNA Methylation, biology.organism_classification, Molecular biology, genomic DNA, repair, Mutation, CCAAT-Enhancer-Binding Proteins, Homologous recombination, 030217 neurology & neurosurgery, DNA, Genome, Bacterial, Mutagens
Abstract

WOS:000452343100012; International audience; Background: Deinococcus radiodurans R1 (DR) survives conditions of extreme desiccation, irradiation and exposure to genotoxic chemicals, due to efficient DNA breaks repair, also through Mn2+ protection of DNA repair enzymes. Methods: Possible annotated domains of the DR1533 locus protein (Shp) were searched by bioinformatic analysis. The gene was cloned and expressed as fusion protein. Band-shift assays of Shp or the SRA and HNH domains were performed on oligonucleotides, genomic DNA from E. coif and DR. slip knock-out mutant was generated by homologous recombination with a kanamycin resistance cassette. Results: DR1533 contains an N-terminal SRA domain and a C-terminal HNH motif (SRA-HNH Protein, Shp). Through its SRA domain, Shp binds double-strand oligonucleotides containing 5mC and 5hmC, but also unmethylated and mismatched cytosines in presence of Mn2+. Shp also binds to Escherichia coli dcm(+) genomic DNA, and to cytosine unmethylated DR and E. coli dcm(-) genomic DNAs, but only in presence of Mn2+. Under these binding conditions, Shp displays DNAse activity through its HNH domain. Shp KO enhanced \textgreater 100 fold the number of spontaneous mutants, whilst the treatment with DNA double strand break inducing agents enhanced up to 3-log the number of survivors. Conclusions: The SRA-HNH containing protein Shp binds to and cuts 5mC DNA, and unmethylated DNA in a Mn2+ dependent manner, and might be involved in faithful genome inheritance maintenance following DNA damage. General significance: Our results provide evidence for a potential role of DR Shp protein for genome integrity maintenance, following DNA double strand breaks induced by genotoxic agents.

Published
2019

40. Impact of nuchal cord on antenatal and intrapartum foetal heart rate surveillance and perinatal outcome

Author

Maurizio Guida, Giovanni Magenes, Gabriele Saccone, Giuseppina Esposito, Francesca Giovanna Esposito, Marta Campanile, Fulvio Zullo, Salvatore Tagliaferri, Maria G. Signorini, Tagliaferri, S., Esposito, F. G., Esposito, G., Saccone, G., Signorini, M. G., Magenes, G., Campanile, M., Guida, M., and Zullo, F.

Subjects
medicine.medical_specialty, Cardiotocography, Term Birth, Birth weight, Perinatal outcome, Foetal heart rate, labour, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, medicine, obstetric, Birth Weight, Humans, signal interpretation, reproductive and urinary physiology, Retrospective Studies, Foetal monitoring, Observer Variation, Labor, Obstetric, 030219 obstetrics & reproductive medicine, pregnancy outcome, medicine.diagnostic_test, business.industry, Vaginal delivery, Obstetrics, Infant, Newborn, Reproducibility of Results, Obstetrics and Gynecology, nuchal cord, Heart Rate, Fetal, Delivery, Obstetric, medicine.disease, female genital diseases and pregnancy complications, 030220 oncology & carcinogenesis, computer-assisted, Foetal monitoring, labour, obstetric, nuchal cord, pregnancy outcome, signal interpretation, computer-assisted, Gestation, Female, Apgar score, Nuchal cord, business
Abstract

Analysing antepartum and intrapartum computerised cardiotocographic (cCTG) parameters in physiological term pregnancies with nuchal (NC) or body cord (BC), in order to correlate them with labour events and neonatal outcome. We enrolled 808 pregnant women, composed of 264 with ‘one NC’, 121 with ‘multiple NCs’, 39 with BC and 384 with ‘no NC’, were monitored from the 37th week of gestation before labour, while 49 pregnant women with ‘one or more NCs’ and 47 with ‘no NCs’ were analysed during labour. No differences in maternal characteristics, foetal pH at birth and 5-min Apgar score were observed. The birth weight was significantly lower in the ‘multiple NCs’ group, while 1-minute Apgar score was lower in the BC group than the other groups, respectively. No relevant differences in cCTG parameters were observed, except for LTI, Delta and number of variable decelerations in antepartum period and only variable deceleration in intrapartum period.Impact statementWhat is already known on this subject? Ultrasound cannot predict which foetuses with NCs are likely to have problem during labour. The question arose if single or multiple NC could affects FHR monitoring prior and during labour. What do the results of this study add? Computerised cardiotocography (cCTG) is a standardised method developed to reduce inter- and intra-observer variability and the poor reproducibility of visual analysis. Few studies have investigated the influence of NCs on FHR variability and, to our knowledge, no one has evaluated its linear and nonlinear characteristics in antepartum and intrapartum period using a computerised analysis system. No differences in maternal characteristics, foetal pH at birth and 5-min Apgar score were observed. Birth weight was significantly lower in the ‘multiple NCs’ group, while 1-min Apgar score was lower in the BC group than the other groups, respectively. Foetuses with ‘one or more NCs’ evidenced a larger number of prolonged second stage and meconium-stained liquor cases, while the operative vaginal delivery and emergency caesarean section rates were unchanged. No relevant differences in cCTG parameters were observed, except for LTI, Delta and number of variable decelerations in antepartum period and only variable deceleration in intrapartum period. What are the implications of these findings for clinical practice and/or further research? cCTG monitoring results confirmed their usefulness for assessing the state of good oxygenation for all foetuses investigated.

Published
2019

41. Everolimus restores gefitinib sensitivity in resistant non-small cell lung cancer cell lines

Author

Pier Giorgio Petronini, Matteo Goldoni, Sara Tagliaferri, Maricla Galetti, Marzia Capelletti, Andrea Ardizzoni, Marcello Tiseo, Mara Bonelli, Daniele Generali, Silvia La Monica, Roberta Alfieri, Antonio Mutti, Andrea Cavazzoni, Claudia Fumarola, La Monica S, Galetti M, Alfieri RR, Cavazzoni A, Ardizzoni A, Tiseo M, Capelletti M, Goldoni M, Tagliaferri S, Mutti A, Fumarola C, Bonelli M, Generali D, Petronini PG, La Monica, Silvia, Galetti, Maricla, Alfieri, Roberta R, Cavazzoni, Andrea, Ardizzoni, Andrea, Tiseo, Marcello, Capelletti, Marzia, Goldoni, Matteo, Tagliaferri, Sara, Mutti, Antonio, Fumarola, Claudia, Bonelli, Mara, Generali, Daniele, and Petronini, Pier Giorgio

Subjects
Lung Neoplasms, Biochemistry, Tyrosine-kinase inhibitor, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, heterocyclic compounds, Epidermal growth factor receptor, Phosphorylation, Everolimus, gefitinib, non-small cell lung cancer, cell lines, 0303 health sciences, Drug Synergism, Gefitinib, 3. Good health, ErbB Receptors, Everolimu, 030220 oncology & carcinogenesis, Erlotinib, Lung cancer, Immunosuppressive Agents, Signal Transduction, medicine.drug, medicine.medical_specialty, medicine.drug_class, EGFR, Antineoplastic Agents, P70-S6 Kinase 1, Biology, 03 medical and health sciences, Cell Line, Tumor, Internal medicine, medicine, Humans, Everolimus, neoplasms, PI3K/AKT/mTOR pathway, 030304 developmental biology, Sirolimus, Pharmacology, Ribosomal Protein S6 Kinases, medicine.disease, respiratory tract diseases, Endocrinology, Drug Resistance, Neoplasm, Quinazolines, Cancer research, biology.protein
Abstract

The epidermal growth factor receptor(EGFR) is a validated target for therapy in non-small cell lung cancer (NSCLC). Most patients, however, either do not benefit or develop resistance to specific inhibitors of the EGFR tyrosine kinase activity, such as gefitinib or erlotinib. The mammalian target of rapamycin (mTOR) is a key intracellular kinase integrating proliferation and survival pathways and has been associated with resistance to EGFR tyrosine kinase inhibitors. In this study, we assessed the effects of combining the mTOR inhibitor everolimus (RAD001) with gefitinib on a panel of NSCLC cell lines characterized by gefitinib resistance and able to maintain S6K phosphorylation after gefitinib treatment. Everolimus plus gefitinib induced a significant decrease in the activation of MAPK and mTOR signaling pathways downstream of EGFR and resulted in a growth-inhibitory effect rather than in an enhancement of cell death. A synergistic effect was observed in those cell lines characterized by high proliferative index and low doubling time. These data suggest that treatment with everolimus and gefitinib might be of value in the treatment of selected NSCLC patients that exhibit high tumor proliferative activity. (C) 2009 Elsevier Inc. All rights reserved. RI goldoni, matteo/E-9153-2011; Mutti, Antonio/C-1095-2011

Published
2009

42. The Transient High Energy Sky and Early Universe Surveyor (THESEUS)

Author

Amati, L., O Brien, P., Goetz, D., Bozzo, E., Tenzer, C., Frontera, F., Ghirlanda, G., Labanti, C., Osborne, J. P., Stratta, G., Tanvir, N., Willingale, R., Attina, P., Campana, R., Castro-Tirado, A. J., Contini, C., Fuschino, F., Gomboc, A., Hudec, R., Orleanski, P., Renotte, E., Rodic, T., Bagoly, Z., Blain, A., Callanan, P., Covino, S., Ferrara, A., Le Floch, E., Marisaldi, M., Mereghetti, S., Rosati, P., Vacchi, A., D Avanzo, P., Giommi, P., Piranomonte, S., Piro, L., Reglero, V., Rossi, A., Santangelo, A., Salvaterra, R., Tagliaferri, G., Vergani, S., Vinciguerra, S., Briggs, M., Campolongo, E., Ciolfi, R., Connaughton, V., Cordier, B., Morelli, B., Orlandini, M., Adami, C., Argan, A., Atteia, J. -L, Auricchio, N., Balazs, L., Baldazzi, G., Basa, S., Basak, R., Bellutti, P., Bernardini, M. G., Bertuccio, G., Braga, J., Branchesi, M., Brandt, S., Brocato, E., Budtz-Jorgensen, C., Bulgarelli, A., Burderi, L., Camp, J., Capozziello, S., Caruana, J., Casella, P., Cenko, B., Chardonnet, P., Ciardi, B., Colafrancesco, S., Dainotti, M. G., D Elia, V., Martino, D., Pasquale, M., Del Monte, E., Della Valle, M., Drago, A., Evangelista, Y., Feroci, M., Finelli, F., Fiorini, M., Fynbo, J., Gal-Yam, A., Gendre, B., Ghisellini, G., Grado, A., Guidorzi, C., Hafizi, M., Hanlon, L., Hjorth, J., Izzo, L., Kiss, L., Kumar, P., Kuvvetli, I., Lavagna, M., Li, T., Longo, F., Lyutikov, M., Maio, U., Maiorano, E., Malcovati, P., Malesani, D., Margutti, R., Martin-Carrillo, A., Masetti, N., Mcbreen, S., Mignani, R., Morgante, G., Mundell, C., Nargaard-Nielsen, H. U., Nicastro, L., Palazzi, E., Paltani, S., Panessa, F., Pareschi, G., Pe Er, A., Penacchioni, A. V., Pian, E., Piedipalumbo, E., Piran, T., Rauw, G., Razzano, M., Read, A., Rezzolla, L., Romano, P., Ruffini, R., Savaglio, S., Sguera, V., Schady, P., Skidmore, W., Song, L., Stanway, E., Starling, R., Topinka, M., Troja, E., Putten, M., Vanzella, E., Vercellone, S., Wilson-Hodge, C., Yonetoku, D., Zampa, G., Zampa, N., Zhang, B., Zhang, B. B., Zhang, S., Zhang, S. -N, Antonelli, A., Bianco, F., Boci, S., Boer, M., Botticella, M. T., Boulade, O., Butler, C., Campana, S., Capitanio, F., Celotti, A., Chen, Y., Colpi, M., Comastri, A., Cuby, J. -G, Dadina, M., Andrea De Luca, Dong, Y. -W, Ettori, S., Gandhi, P., Geza, E., Greiner, J., Guiriec, S., Harms, J., Hernanz, M., Hornstrup, A., Hutchinson, I., Israel, G., Jonker, P., Kaneko, Y., Kawai, N., Wiersema, K., Korpela, S., Lebrun, V., Lu, F., Macfadyen, A., Malaguti, G., Maraschi, L., Melandri, A., Modjaz, M., Morris, D., Omodei, N., Paizis, A., Pata, P., Petrosian, V., Rachevski, A., Rhoads, J., Ryde, F., Sabau-Graziati, L., Shigehiro, N., Sims, M., Soomin, J., Szecsi, D., Urata, Y., Uslenghi, M., Valenziano, L., Vianello, G., Vojtech, S., Watson, D., Zicha, J., and L. Amati, P. O’Brien, D. Goetz, E. Bozzo, C. Tenzer, F. Frontera, G. Ghirlanda, C. Labanti, J. P. Osborne, G. Stratta, N. Tanvir, R. Willingale , P. Attina, R. Campana, A.J. Castro-Tirado, C. Contini, F. Fuschino, A. Gomboc, R. Hudec, P. Orleanski, E. Renotte, T. Rodic, Z. Bagoly, A. Blain, P. Callanan, S. Covino, A. Ferrara, E. Le Floch, M. Marisaldi, S. Mereghetti, P. Rosati, A. Vacchi, P. D’Avanzo, P. Giommi, A. Gomboc, S. Piranomonte, L. Piro, V. Reglero, A. Rossi, A. Santangelo, R. Salvaterra, G. Tagliaferri, S. Vergani, S. Vinciguerra, M. Briggs, E. Campolongo, R. Ciolfi, V. Connaughton, B. Cordier, B. Morelli, M. Orlandini, C. Adami, A. Argan, J.-L. Atteia, N. Auricchio, L. Balazs, G. Baldazzi, S. Basa, R. Basak, P. Bellutti, M. G. Bernardini, G. Bertuccio, J. Braga, M. Branchesi, S. Brandt, E. Brocato, C. Budtz-Jorgensen, A. Bulgarelli, L. Burderi, J. Camp, S. Capozziello, J. Caruana, P. Casella, B. Cenko, P. Chardonnet, B. Ciardi, S. Colafrancesco, M. G. Dainotti, V. D’Elia, D. De Martino, M. De Pasquale, E. Del Monte, M. Della Valle, A. Drago, Y. Evangelista, M. Feroci, F. Finelli, M. Fiorini, J. Fynbo, A. Gal-Yam, B. Gendre, G. Ghisellini, A. Grado, C. Guidorzi, M. Hafizi, L. Hanlon, J. Hjorth, L. Izzo, L. Kiss, P. Kumar, I. Kuvvetli, M. Lavagna, T. Li, F. Longo, M. Lyutikov, U. Maio, E. Maiorano, P. Malcovati, D. Malesani, R. Margutti, A. Martin-Carrillo, N. Masetti, S. McBreen, R. Mignani, G. Morgante, C. Mundell, H. U. Nargaard-Nielsen, L. Nicastro, E. Palazzi, S. Paltani, F. Panessa, G. Pareschi, A. Pe’er, A. V. Penacchioni, E. Pian, E. Piedipalumbo, T. Piran, G. Rauw, M. Razzano, A. Read, L. Rezzolla, P. Romano, R. Ruffini, S. Savaglio, V. Sguera, P. Schady, W. Skidmore, L. Song, E. Stanway, R. Starling, M. Topinka, E. Troja, M. van Putten, E. Vanzella, S. Vercellone, C. Wilson-Hodge, D. Yonetoku, G. Zampa, N. Zampa, B. Zhang, B. B. Zhang, S. Zhang, S.-N. Zhang, A. Antonelli, F. Bianco, S. Boci, M. Boer, M. T. Botticella, O. Boulade, C. Butler, S. Campana, F. Capitanio, A. Celotti, Y. Chen, M. Colpi, A. Comastri, J.-G. Cuby, M. Dadina, A. De Luca, Y.-W. Dong, S. Ettori, P. Gandhi, E. Geza, J. Greiner, S. Guiriec, J. Harms, M. Hernanz, A. Hornstrup, I. Hutchinson, G. Israel, P. Jonker, Y. Kaneko, N. Kawai, K. Wiersema, S. Korpela, V. Lebrun, F. Lu, A. MacFadyen, G. Malaguti, L. Maraschi, A. Melandri, M. Modjaz, D. Morris, N. Omodei, A. Paizis, P. P´ata, V. Petrosian, A. Rachevski, J. Rhoads, F. Ryde, L. Sabau-Graziati, N. Shigehiro, M. Sims, J. Soomin, D. Szecsi, Y. Urata, M. Uslenghi, L. Valenziano, G. Vianello, S. Vojtech, D. Watson, J. Zicha

Subjects
Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Gamma-ray bursts, Cosmology: observations, dark ages, re-ionization, first stars, Astrophysics::Galaxy Astrophysics
Abstract

THESEUS is a space mission concept aimed at exploiting Gamma-Ray Bursts for investigating the early Universe and at providing a substantial advancement of multi-messenger and time-domain astrophysics. These goals will be achieved through a unique combination of instruments allowing GRBs and X-ray transients detection over a broad FOV (more than 1sr) with 0.5-1 arcmin localization, an energy band extending from several MeVs down to 0.3 keV and high sensitivity to transient sources in the soft X-ray domain, as well as on-board prompt (few minutes) follow-up with a 0.7 m class IR telescope with both imaging and spectroscopic capabilities. THESEUS will be perfectly suited for addressing the main open issues in cosmology such as, e.g., star formation rate and metallicity evolution of the inter-stellar and intra-galactic medium up to redshift ∼10, signatures of Pop III stars, sources and physics of re-ionization, and the faint end of the galaxy luminosity function. In addition, it will provide unprecedented capability to monitor the X-ray variable sky, thus detecting, localizing, and identifying the electromagnetic counterparts to sources of gravitational radiation, which may be routinely detected in the late '20s / early '30s by next generation facilities like aLIGO/ aVirgo, eLISA, KAGRA, and Einstein Telescope. THESEUS will also provide powerful synergies with the next generation of multi-wavelength observatories (e.g., LSST, ELT, SKA, CTA, ATHENA).

43. Consensus of algorithms for lesion segmentation in brain MRI studies of multiple sclerosis.

Author

De Rosa AP, Benedetto M, Tagliaferri S, Bardozzo F, D'Ambrosio A, Bisecco A, Gallo A, Cirillo M, Tagliaferri R, and Esposito F

Subjects
Humans, Female, Consensus, Male, Image Processing, Computer-Assisted methods, Adult, Deep Learning, Image Interpretation, Computer-Assisted methods, Middle Aged, Multiple Sclerosis diagnostic imaging, Multiple Sclerosis pathology, Magnetic Resonance Imaging methods, Algorithms, Brain diagnostic imaging, Brain pathology
Abstract

Segmentation of multiple sclerosis (MS) lesions on brain MRI scans is crucial for diagnosis, disease and treatment monitoring but is a time-consuming task. Despite several automated algorithms have been proposed, there is still no consensus on the most effective method. Here, we applied a consensus-based framework to improve lesion segmentation on T1-weighted and FLAIR scans. The framework is designed to combine publicly available state-of-the-art deep learning models, by running multiple segmentation tasks before merging the outputs of each algorithm. To assess the effectiveness of the approach, we applied it to MRI datasets from two different centers, including a private and a public dataset, with 131 and 30 MS patients respectively, with manually segmented lesion masks available. No further training was performed for any of the included algorithms. Overlap and detection scores were improved, with Dice increasing by 4-8% and precision by 3-4% respectively for the private and public dataset. High agreement was obtained between estimated and true lesion load (ρ = 0.92 and ρ = 0.97) and count (ρ = 0.83 and ρ = 0.94). Overall, this framework ensures accurate and reliable results, exploiting complementary features and overcoming some of the limitations of individual algorithms., (© 2024. The Author(s).)

Published
2024
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44. Biochar dust emission: Is it a health concern? Preliminary results for toxicity assessment.

Author

Pinelli S, Rossi S, Malcevschi A, Miragoli M, Corradi M, Selis L, Tagliaferri S, Rossi F, Cavallo D, Ursini CL, Poli D, and Mozzoni P

Subjects
Animals, Male, Humans, Rats, Wistar, Reactive Oxygen Species metabolism, Air Pollutants toxicity, Rats, Cell Proliferation drug effects, Adenosine Triphosphate metabolism, Oxidative Stress drug effects, Interleukin-8 metabolism, Particulate Matter toxicity, Charcoal, Dust analysis
Abstract

Biochar is currently garnering interest as an alternative to commercial fertilizer and as a tool to counteract global warming. However, its use is increasingly drawing attention, particularly concerning the fine dust that can be developed during its manufacture, transport, and use. This work aimed to assess the toxicity of fine particulate Biochar (10 ) via in-vitro and in-vivo experiments as a first step for the evaluation of toxicity values. As in-vitro experiments, cell lines showed inhibition of proliferation following the reduction of expression genes involved in cell cycle control, increase in the production of ROS and IL-8, and decrease in intracellular ATP. In-vivo rat exposure induced hyperemia, edema, and inflammatory phenomena with infiltrations of neutrophil granulocytes and macrophages at the alveolar and bronchiolar levels. Both in-vitro and in-vivo studies highlighted how exposure to Biochar particulates leads to an inflammatory condition and oxidative stress., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2024
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45. Topical use of tobramycin: A possible innovative treatment of severe skin chronic ulcers.

Author

Cirielli C, Facchiano F, Picardo M, Benedetto M, Tagliaferri R, Tagliaferri S, Piccinni G, Panebianco A, and Facchiano A

Subjects
Humans, Chronic Disease, Administration, Topical, Male, Female, Aged, Tobramycin administration & dosage, Tobramycin therapeutic use, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents therapeutic use, Skin Ulcer drug therapy
Published
2024
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47. The importance of context (placebo effects) in conservative interventions for musculoskeletal pain: A systematic review and meta-analysis of randomized controlled trials.

Author

Saueressig T, Owen PJ, Pedder H, Tagliaferri S, Kaczorowski S, Altrichter A, Richard A, Miller CT, Donath L, and Belavy DL

Abstract

Background and Objective: Contextual effects (e.g. patient expectations) may play a role in treatment effectiveness. This study aimed to estimate the magnitude of contextual effects for conservative, non-pharmacological interventions for musculoskeletal pain conditions. A systematic review and meta-analysis of randomized controlled trials (RCTs) that compared placebo conservative non-pharmacological interventions to no treatment for musculoskeletal pain. The outcomes assessed included pain intensity, physical functioning, health-related quality of life, global rating of change, depression, anxiety and sleep at immediate, short-, medium- and/or long-term follow-up., Databases and Data Treatment: MEDLINE, EMBASE, CINAHL, Web of Science Core Collection, CENTRAL and SPORTDiscus were searched from inception to September 2021. Trial registry searches, backward and forward citation tracking and searches for prior systematic reviews were completed. The Cochrane risk of bias 2 tool was implemented., Results: The study included 64 RCTs (N = 4314) out of 8898 records. For pain intensity, a mean difference of (MD: -5.32, 95% confidence interval (CI): -7.20, -3.44, N = 57 studies with 74 outcomes, GRADE: very low) was estimated for placebo interventions. A small effect in favour of the placebo interventions for physical function was estimated (SMD: -0.22, 95% CI: -0.35, -0.09; N = 37 with 48 outcomes, GRADE: very low). Similar results were found for a broad range of patient-reported outcomes. Meta-regression analyses did not explain heterogeneity among analyses., Conclusion: The study found that the contextual effect of non-pharmacological conservative interventions for musculoskeletal conditions is likely to be small. However, given the known effect sizes of recommended evidence-based treatments for musculoskeletal conditions, it may still contribute an important component., Significance: Contextual effects of non-pharmacological conservative interventions for musculoskeletal conditions are likely to be small for a broad range of patient-reported outcomes (pain intensity, physical function, quality of life, global rating of change and depression). Contextual effects are unlikely, in isolation, to offer much clinical care. But these factors do have relevance in an overall treatment context as they provide almost 30% of the minimally clinically important difference., (© 2023 The Authors. European Journal of Pain published by John Wiley & Sons Ltd on behalf of European Pain Federation ‐ EFIC ®.)

Published
2024
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48. 3D printing of layered vanadium disulfide for water-in-salt electrolyte zinc-ion batteries.

Author

Tagliaferri S, Nagaraju G, Sokolikova M, Quintin-Baxendale R, and Mattevi C

Abstract

Miniaturized aqueous zinc ion batteries are attractive energy storage devices for wearable electronics, owing to their safety and low cost. Layered vanadium disulfide (VS 2 ) has demonstrated competitive charge storage capability for aqueous zinc ion batteries, as a result of its multivalent states and large interlayer spacing. However, VS 2 electrodes are affected by quick oxide conversion, and they present predefined geometries and aspect ratios, which hinders their integration in wearables devices. Here, we demonstrate the formulation of a suitable ink for extrusion-based 3D printing (direct ink writing) based on micro flowers of layered VS 2 obtained using a scalable hydrothermal process. 3D printed architectures of arbitrary design present electrochemically active, porous and micron-sized struts with tuneable mass loading. These were used as cathodes for aqueous zinc-ion battery electrodes. The 3D printed VS 2 cathodes were assembled with carbon/zinc foil anodes to form full cells of zinc-ion, demonstrating a capacity of ∼1.98 mA h cm -2 with an operating voltage of 1.5 V. Upon cycling a capacity retention of around 65% was achieved after ∼100 cycles. The choice of the electrolyte (a water-in-salt electrolyte) and the design of the pre-processing of the 3D printed cathode ensured improved stability against dissolution and swift oxidation, notorious challenges for VS 2 in an aqueous environment. This works paves the way towards programmable manufacturing of miniaturized aqueous batteries and the materials processing approach can be applied to different materials and battery systems to improve stability.

Published
2024
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49. Awareness and attitude among general dentists and orthodontists toward obstructive sleep apnea in children.

Author

Arcidiacono L, Santagostini A, Tagliaferri S, Ghezzi B, Manfredi E, and Segù M

Abstract

Aim: This study aimed to investigate Italian dentists' knowledge of and attitudes toward obstructive sleep apnea (OSA) in children., Methods: An anonymous questionnaire was prepared using Google Forms and sent to dentists in Italy through private social platforms. The first part of the questionnaire contained basic demographic data questions, and the second part included items about pediatric OSA., Results: A total of 125 responses were collected within 1 month. The interviews revealed gaps in undergraduate and post-graduate training on OSA, and consequently, low self-evaluation of knowledge and self-confidence in managing young patients with OSA. Dentists showed unfavorable attitudes and poor knowledge of the general findings, risk factors, and consequences of pediatric OSA but demonstrated good knowledge of the beneficial effects of rapid maxillary expansion. Orthodontists showed a more favorable attitude and better recognition of the craniofacial features associated with OSA. In addition, a comparison was made between dentists who had graduated more than 5 years ago and new graduates, and differences were found in undergraduate education, which was better for new graduates, and a small number of questions were better answered by experienced dentists., Conclusion: This study showed a lack of knowledge about pediatric OSA and its management among Italian dentists, revealing the need to update the dentistry curriculum and organize educational interventions., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Arcidiacono, Santagostini, Tagliaferri, Ghezzi, Manfredi and Segù.)

Published
2024
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50. Survival and success of zirconia compared with titanium implants: a systematic review and meta-analysis.

Author

Padhye NM, Calciolari E, Zuercher AN, Tagliaferri S, and Donos N

Subjects
Humans, Titanium, Dental Restoration Failure, Esthetics, Dental, Zirconium, Dental Prosthesis Design, Dental Implants
Abstract

Objective: This systematic review assessed the available evidence on the survival and success rate of zirconia and titanium implants. As secondary outcomes, aesthetic, radiographic and clinical parameters, as well as biological and mechanical complications, were considered., Materials and Methods: A systematic search was performed up to March 2022 to identify CCTs/RCTs comparing zirconia and titanium implants with a minimum of 12 months of follow-up. Meta-analysis was performed when ≥ 2 articles with similar characteristics were retrieved., Results: Four published articles with two RCTs (2 different patient populations) with 100 zirconia and 99 titanium implants that were followed up over 12-80 months were selected out of the 6040 articles. A non-statistically significant difference between zirconia and titanium implant survival at 12 months was suggested (P = 0.0938). The success rates were 57.5-93.3% and 57.1-100% for zirconia and titanium implants, respectively. The pink aesthetic score (PES) was higher for zirconia (10.33 ± 2.06 to 11.38 ± 0.92) compared to titanium implants (8.14 ± 3.58 to 11.56 ± 1.0)., Conclusion: Based on the 2 RCTs retrieved in the literature, similar survival rates were reported for zirconia and titanium implants in the short term (12 months of follow-up). Future RCTs are warranted to evaluate the long-term outcomes of zirconia implants., Clinical Relevance: Zirconia implants may be the procedure of choice, particularly in the aesthetic zone, since they show a similar survival and success rate as titanium implants on a short-term follow-up., Trial Registration: Systematic review registration number-CRD42021288704 (PROSPERO)., (© 2023. The Author(s).)

Published
2023
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