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1. Rectal cancer lexicon 2023 revised and updated consensus statement from the Society of Abdominal Radiology Colorectal and Anal Cancer Disease-Focused Panel.

Author

Chang, Kevin, Korngold, Elena, Taggart, Melissa, Horvat, Natally, Kassam, Zahra, Baheti, Akshay, Hope, Thomas, and Lee, Sonia

Subjects
Gastrointestinal tract, MRI, Oncology, Rectal adenocarcinoma, Rectal cancer, Humans, Rectal Neoplasms, Anus Neoplasms, Rectum, Neoplasm Staging, Magnetic Resonance Imaging, Radiology
Abstract

The Society of Abdominal Radiologys Colorectal and Anal Cancer Disease-Focused Panel (DFP) first published a rectal cancer lexicon paper in 2019. Since that time, the DFP has published revised initial staging and restaging reporting templates, and a new SAR user guide to accompany the rectal MRI synoptic report (primary staging). This lexicon update summarizes interval developments, while conforming to the original lexicon 2019 format. Emphasis is placed on primary staging, treatment response, anatomic terminology, nodal staging, and the utility of specific sequences in the MRI protocol. A discussion of primary tumor staging reviews updates on tumor morphology and its clinical significance, T1 and T3 subclassifications and their clinical implications, T4a and T4b imaging findings/definitions, terminology updates on the use of MRF over CRM, and the conundrum of the external sphincter. A parallel section on treatment response reviews the clinical significance of near-complete response and introduces the lexicon of regrowth versus recurrence. A review of relevant anatomy incorporates updated definitions and expert consensus of anatomic landmarks, including the NCCNs new definition of rectal upper margin and sigmoid take-off. A detailed review of nodal staging is also included, with attention to tumor location relative to the dentate line and locoregional lymph node designation, a new suggested size threshold for lateral lymph nodes and their indications for use, and imaging criteria used to differentiate tumor deposits from lymph nodes. Finally, new treatment terminologies such as organ preservation, TNT, TAMIS and watch-and-wait management are introduced. This 2023 version aims to serve as a concise set of up-to-date recommendations for radiologists, and discusses terminology, classification systems, MRI and clinical staging, and the evolving concepts in diagnosis and treatment of rectal cancer.

Published
2023

2. Repeat Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Recurrent Mucinous Appendiceal Adenocarcinoma: A Viable Treatment Strategy with Demonstrable Benefit

Author

Bhutiani, Neal, Grotz, Travis E., Concors, Seth J., White, Michael G., Helmink, Beth A., Raghav, Kanwal P., Taggart, Melissa W., Beaty, Karen A., Royal, Richard E., Overman, Michael J., Matamoros, Aurelio, Scally, Christopher P., Rafeeq, Safia, Mansfield, Paul F., and Fournier, Keith F.

Published
2024
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7. Genomic Landscape of Lynch Syndrome Colorectal Neoplasia Identifies Shared Mutated Neoantigens for Immunoprevention

Author

Bolivar, Ana M., Duzagac, Fahriye, Deng, Nan, Reyes-Uribe, Laura, Chang, Kyle, Wu, Wenhui, Bowen, Charles M., Taggart, Melissa W., Thirumurthi, Selvi, Lynch, Patrick M., You, Y. Nancy, Rodriguez-Pascual, Jesus, Lipkin, Steven M., Kopetz, Scott, Scheet, Paul, Lizee, Gregory A., Reuben, Alexandre, Sinha, Krishna M., and Vilar, Eduardo

Published
2024
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8. Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa

Author

Reyes-Uribe, Laura, Wu, Wenhui, Gelincik, Ozkan, Bommi, Prashant V, Francisco-Cruz, Alejandro, Solis, Luisa M, Lynch, Patrick M, Lim, Ramona, Stoffel, Elena M, Kanth, Priyanka, Samadder, N Jewel, Mork, Maureen E, Taggart, Melissa W, Milne, Ginger L, Marnett, Lawrence J, Vornik, Lana, Liu, Diane D, Revuelta, Maria, Chang, Kyle, You, Y Nancy, Kopelovich, Levy, Wistuba, Ignacio I, Lee, J Jack, Sei, Shizuko, Shoemaker, Robert H, Szabo, Eva, Richmond, Ellen, Umar, Asad, Perloff, Marjorie, Brown, Powel H, Lipkin, Steven M, and Vilar, Eduardo

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Biotechnology, Digestive Diseases, Colo-Rectal Cancer, Cancer, Prevention, Clinical Trials and Supportive Activities, Clinical Research, Genetics, Adult, Aged, Animals, Anti-Inflammatory Agents, Non-Steroidal, Chemoprevention, Colorectal Neoplasms, Hereditary Nonpolyposis, Dinoprostone, Disease Models, Animal, Female, Humans, Intestinal Mucosa, Male, Mice, Middle Aged, Naproxen, HNPCC syndrome, cancer syndromes, chemoprevention, gene expression, non-steroidal anti-inflammatory drugs, Clinical Sciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

ObjectivePatients with Lynch syndrome (LS) are at markedly increased risk for colorectal cancer. It is being increasingly recognised that the immune system plays an essential role in LS tumour development, thus making an ideal target for cancer prevention. Our objective was to evaluate the safety, assess the activity and discover novel molecular pathways involved in the activity of naproxen as primary and secondary chemoprevention in patients with LS.DesignWe conducted a Phase Ib, placebo-controlled, randomised clinical trial of two dose levels of naproxen sodium (440 and 220 mg) administered daily for 6 months to 80 participants with LS, and a co-clinical trial using a genetically engineered mouse model of LS and patient-derived organoids (PDOs).ResultsOverall, the total number of adverse events was not different across treatment arms with excellent tolerance of the intervention. The level of prostaglandin E2 in the colorectal mucosa was significantly decreased after treatment with naproxen when compared with placebo. Naproxen activated different resident immune cell types without any increase in lymphoid cellularity, and changed the expression patterns of the intestinal crypt towards epithelial differentiation and stem cell regulation. Naproxen demonstrated robust chemopreventive activity in a mouse co-clinical trial and gene expression profiles induced by naproxen in humans showed perfect discrimination of mice specimens with LS and PDOs treated with naproxen and control.ConclusionsNaproxen is a promising strategy for immune interception in LS. We have discovered naproxen-induced gene expression profiles for their potential use as predictive biomarkers of drug activity.Trial registration numbergov Identifier: NCT02052908.

Published
2021

10. Figure 1 from PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis

Author

Meuser, Elena, primary, Chang, Kyle, primary, Walters, Angharad, primary, Hurley, Joanna J., primary, West, Hannah D., primary, Perry, Iain, primary, Mort, Matthew, primary, Reyes-Uribe, Laura, primary, Truscott, Rebekah, primary, Jones, Nicholas, primary, Lawrence, Rachel, primary, Jenkins, Gareth, primary, Giles, Peter, primary, Dolwani, Sunil, primary, Al-Sarireh, Bilal, primary, Hawkes, Neil, primary, Short, Emma, primary, Williams, Geraint T., primary, Taggart, Melissa W., primary, Luetchford, Kim, primary, Lynch, Patrick M., primary, Terlouw, Diantha, primary, Nielsen, Maartje, primary, Walton, Sarah-Jane, primary, Latchford, Andrew, primary, Clark, Susan K., primary, Sampson, Julian R., primary, Vilar, Eduardo, primary, and Thomas, Laura E., primary

Published
2024
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11. Supplementary Table S3 from PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis

Author

Meuser, Elena, primary, Chang, Kyle, primary, Walters, Angharad, primary, Hurley, Joanna J., primary, West, Hannah D., primary, Perry, Iain, primary, Mort, Matthew, primary, Reyes-Uribe, Laura, primary, Truscott, Rebekah, primary, Jones, Nicholas, primary, Lawrence, Rachel, primary, Jenkins, Gareth, primary, Giles, Peter, primary, Dolwani, Sunil, primary, Al-Sarireh, Bilal, primary, Hawkes, Neil, primary, Short, Emma, primary, Williams, Geraint T., primary, Taggart, Melissa W., primary, Luetchford, Kim, primary, Lynch, Patrick M., primary, Terlouw, Diantha, primary, Nielsen, Maartje, primary, Walton, Sarah-Jane, primary, Latchford, Andrew, primary, Clark, Susan K., primary, Sampson, Julian R., primary, Vilar, Eduardo, primary, and Thomas, Laura E., primary

Published
2024
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12. Supplementary Figure S5 from PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis

Author

Meuser, Elena, primary, Chang, Kyle, primary, Walters, Angharad, primary, Hurley, Joanna J., primary, West, Hannah D., primary, Perry, Iain, primary, Mort, Matthew, primary, Reyes-Uribe, Laura, primary, Truscott, Rebekah, primary, Jones, Nicholas, primary, Lawrence, Rachel, primary, Jenkins, Gareth, primary, Giles, Peter, primary, Dolwani, Sunil, primary, Al-Sarireh, Bilal, primary, Hawkes, Neil, primary, Short, Emma, primary, Williams, Geraint T., primary, Taggart, Melissa W., primary, Luetchford, Kim, primary, Lynch, Patrick M., primary, Terlouw, Diantha, primary, Nielsen, Maartje, primary, Walton, Sarah-Jane, primary, Latchford, Andrew, primary, Clark, Susan K., primary, Sampson, Julian R., primary, Vilar, Eduardo, primary, and Thomas, Laura E., primary

Published
2024
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13. Data from PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis

Author

Meuser, Elena, primary, Chang, Kyle, primary, Walters, Angharad, primary, Hurley, Joanna J., primary, West, Hannah D., primary, Perry, Iain, primary, Mort, Matthew, primary, Reyes-Uribe, Laura, primary, Truscott, Rebekah, primary, Jones, Nicholas, primary, Lawrence, Rachel, primary, Jenkins, Gareth, primary, Giles, Peter, primary, Dolwani, Sunil, primary, Al-Sarireh, Bilal, primary, Hawkes, Neil, primary, Short, Emma, primary, Williams, Geraint T., primary, Taggart, Melissa W., primary, Luetchford, Kim, primary, Lynch, Patrick M., primary, Terlouw, Diantha, primary, Nielsen, Maartje, primary, Walton, Sarah-Jane, primary, Latchford, Andrew, primary, Clark, Susan K., primary, Sampson, Julian R., primary, Vilar, Eduardo, primary, and Thomas, Laura E., primary

Published
2024
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14. Figure 3 from PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis

Author

Meuser, Elena, primary, Chang, Kyle, primary, Walters, Angharad, primary, Hurley, Joanna J., primary, West, Hannah D., primary, Perry, Iain, primary, Mort, Matthew, primary, Reyes-Uribe, Laura, primary, Truscott, Rebekah, primary, Jones, Nicholas, primary, Lawrence, Rachel, primary, Jenkins, Gareth, primary, Giles, Peter, primary, Dolwani, Sunil, primary, Al-Sarireh, Bilal, primary, Hawkes, Neil, primary, Short, Emma, primary, Williams, Geraint T., primary, Taggart, Melissa W., primary, Luetchford, Kim, primary, Lynch, Patrick M., primary, Terlouw, Diantha, primary, Nielsen, Maartje, primary, Walton, Sarah-Jane, primary, Latchford, Andrew, primary, Clark, Susan K., primary, Sampson, Julian R., primary, Vilar, Eduardo, primary, and Thomas, Laura E., primary

Published
2024
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15. Figure 2 from PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis

Author

Meuser, Elena, primary, Chang, Kyle, primary, Walters, Angharad, primary, Hurley, Joanna J., primary, West, Hannah D., primary, Perry, Iain, primary, Mort, Matthew, primary, Reyes-Uribe, Laura, primary, Truscott, Rebekah, primary, Jones, Nicholas, primary, Lawrence, Rachel, primary, Jenkins, Gareth, primary, Giles, Peter, primary, Dolwani, Sunil, primary, Al-Sarireh, Bilal, primary, Hawkes, Neil, primary, Short, Emma, primary, Williams, Geraint T., primary, Taggart, Melissa W., primary, Luetchford, Kim, primary, Lynch, Patrick M., primary, Terlouw, Diantha, primary, Nielsen, Maartje, primary, Walton, Sarah-Jane, primary, Latchford, Andrew, primary, Clark, Susan K., primary, Sampson, Julian R., primary, Vilar, Eduardo, primary, and Thomas, Laura E., primary

Published
2024
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18. Supplemental Figure 1 from Efficacy and Safety of Atezolizumab and Bevacizumab in Appendiceal Adenocarcinoma

Author

Hornstein, Nicholas J., primary, Zeineddine, Mohammad A., primary, Gunes, Betul B., primary, Pellatt, Andrew J., primary, Knafl, Mark, primary, Zhu, Haifeng, primary, Willett, Anneleis F., primary, Yousef, Abdelrahman, primary, Liu, Suyu, primary, Sun, Ryan, primary, Futreal, Andrew, primary, Woodman, Scott E., primary, Taggart, Melissa W., primary, Overman, Michael J., primary, Halperin, Daniel M., primary, Raghav, Kanwal P., primary, and Shen, John Paul, primary

Published
2024
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19. Data from Efficacy and Safety of Atezolizumab and Bevacizumab in Appendiceal Adenocarcinoma

Author

Hornstein, Nicholas J., primary, Zeineddine, Mohammad A., primary, Gunes, Betul B., primary, Pellatt, Andrew J., primary, Knafl, Mark, primary, Zhu, Haifeng, primary, Willett, Anneleis F., primary, Yousef, Abdelrahman, primary, Liu, Suyu, primary, Sun, Ryan, primary, Futreal, Andrew, primary, Woodman, Scott E., primary, Taggart, Melissa W., primary, Overman, Michael J., primary, Halperin, Daniel M., primary, Raghav, Kanwal P., primary, and Shen, John Paul, primary

Published
2024
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20. Supplementary Tables from Efficacy and Safety of Atezolizumab and Bevacizumab in Appendiceal Adenocarcinoma

Author

Hornstein, Nicholas J., primary, Zeineddine, Mohammad A., primary, Gunes, Betul B., primary, Pellatt, Andrew J., primary, Knafl, Mark, primary, Zhu, Haifeng, primary, Willett, Anneleis F., primary, Yousef, Abdelrahman, primary, Liu, Suyu, primary, Sun, Ryan, primary, Futreal, Andrew, primary, Woodman, Scott E., primary, Taggart, Melissa W., primary, Overman, Michael J., primary, Halperin, Daniel M., primary, Raghav, Kanwal P., primary, and Shen, John Paul, primary

Published
2024
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21. TABLE 1 from Efficacy and Safety of Atezolizumab and Bevacizumab in Appendiceal Adenocarcinoma

Author

Hornstein, Nicholas J., primary, Zeineddine, Mohammad A., primary, Gunes, Betul B., primary, Pellatt, Andrew J., primary, Knafl, Mark, primary, Zhu, Haifeng, primary, Willett, Anneleis F., primary, Yousef, Abdelrahman, primary, Liu, Suyu, primary, Sun, Ryan, primary, Futreal, Andrew, primary, Woodman, Scott E., primary, Taggart, Melissa W., primary, Overman, Michael J., primary, Halperin, Daniel M., primary, Raghav, Kanwal P., primary, and Shen, John Paul, primary

Published
2024
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22. Supplemental Figure 2 from Efficacy and Safety of Atezolizumab and Bevacizumab in Appendiceal Adenocarcinoma

Author

Hornstein, Nicholas J., primary, Zeineddine, Mohammad A., primary, Gunes, Betul B., primary, Pellatt, Andrew J., primary, Knafl, Mark, primary, Zhu, Haifeng, primary, Willett, Anneleis F., primary, Yousef, Abdelrahman, primary, Liu, Suyu, primary, Sun, Ryan, primary, Futreal, Andrew, primary, Woodman, Scott E., primary, Taggart, Melissa W., primary, Overman, Michael J., primary, Halperin, Daniel M., primary, Raghav, Kanwal P., primary, and Shen, John Paul, primary

Published
2024
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23. Supplementary Figures from Peritoneal Microenvironment Promotes Appendiceal Adenocarcinoma Growth: A Multi-omics Approach Using Patient-Derived Xenografts

Author

Pattalachinti, Vinay K., primary, Ito, Ichiaki, primary, Chowdhury, Saikat, primary, Yousef, Abdelrahman, primary, Gu, Yue, primary, Gunes, Betul Beyza, primary, Salle, Emma R., primary, Taggart, Melissa W., primary, Fournier, Keith, primary, Fowlkes, Natalie W., primary, and Shen, John Paul, primary

Published
2024
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24. Supplementary Tables 1-3 from Peritoneal Microenvironment Promotes Appendiceal Adenocarcinoma Growth: A Multi-omics Approach Using Patient-Derived Xenografts

Author

Pattalachinti, Vinay K., primary, Ito, Ichiaki, primary, Chowdhury, Saikat, primary, Yousef, Abdelrahman, primary, Gu, Yue, primary, Gunes, Betul Beyza, primary, Salle, Emma R., primary, Taggart, Melissa W., primary, Fournier, Keith, primary, Fowlkes, Natalie W., primary, and Shen, John Paul, primary

Published
2024
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26. Supplementary Materials from Peritoneal Microenvironment Promotes Appendiceal Adenocarcinoma Growth: A Multi-omics Approach Using Patient-Derived Xenografts

Author

Pattalachinti, Vinay K., primary, Ito, Ichiaki, primary, Chowdhury, Saikat, primary, Yousef, Abdelrahman, primary, Gu, Yue, primary, Gunes, Betul Beyza, primary, Salle, Emma R., primary, Taggart, Melissa W., primary, Fournier, Keith, primary, Fowlkes, Natalie W., primary, and Shen, John Paul, primary

Published
2024
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27. PIGA mutations and glycosylphosphatidylinositol anchor dysregulation in polyposis-associated duodenal tumorigenesis

Author

Meuser, Elena, primary, Chang, Kyle, additional, Walters, Angharad, additional, Hurley, Joanna J., additional, West, Hannah D., additional, Perry, Iain, additional, Mort, Matthew, additional, Reyes-Uribe, Laura, additional, Truscott, Rebekah, additional, Jones, Nicholas, additional, Lawrence, Rachel, additional, Jenkins, Gareth, additional, Giles, Peter, additional, Dolwani, Sunil, additional, Al-Sarireh, Bilal, additional, Hawkes, Neil, additional, Short, Emma, additional, Williams, Geraint T., additional, Taggart, Melissa W., additional, Luetchford, Kim, additional, Lynch, Patrick M., additional, Terlouw, Diantha, additional, Nielsen, Maartje, additional, Walton, Sarah-Jane, additional, Latchford, Andrew, additional, Clark, Susan K., additional, Sampson, Julian R., additional, Vilar, Eduardo, additional, and Thomas, Laura E., additional

Published
2024
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28. From Mixed Hyperplastic/Adenomatous Polyp to Sessile Serrated Lesion: A Long and Winding Road for Long and Winding Crypts

Author

Booth, Adam L., Taggart, Melissa W., Ono, Yuho, and Gonzalez, Raul S.

Subjects
Medical research, Medicine, Experimental, Medical terminology -- Research, Intestinal polyps -- Diagnosis -- Identification and classification, Health
Abstract

* Context.--During the past 3 decades, numerous articles in the literature have offered terminology, diagnostic criteria, and consensus recommendations regarding the entity currently referred to by the World Health Organization as sessile serrated lesion. Given the many names and various, variably reproducible diagnostic criteria ascribed to sessile serrated lesion, confusion persists for many pathologists and gastroenterologists regarding the diagnosis. This distinction is important, as sessile serrated lesion can progress to malignancy, unlike its main differential diagnosis, hyperplastic polyp. Research studies have shed light on the characteristic architecture and morphology, immunohistochemical patterns, and molecular alterations of sessile serrated lesion, and multiple consensus meetings around the globe have developed their criteria and nomenclature, often clashing or mixing terms. Objective.--To provide a narrative review from the entity's early description to our current understanding. Data Sources.--The existing scientific and clinical literature, published texts, medical society recommendations, and specialty consensus guidelines. Conclusions.--The current World Health Organization criteria are a distillation of this scientific process, but terminology is still a point of contention worldwide. doi: 10.5858/arpa.2020-0591-RA, Sessile serrated lesion (SSL) is the current World Health Organization (WHO)-recommended terminology (1) for a type of serrated colorectal polyp characterized by disordered maturation, abnormal basal crypt growth, and propensity [...]

Published
2021
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30. Serum Tumor Markers and Outcomes in Patients With Appendiceal Adenocarcinoma

Author

Yousef, Abdelrahman, primary, Yousef, Mahmoud, additional, Zeineddine, Mohammad A., additional, More, Aditya, additional, Fanaeian, Mohammad, additional, Chowdhury, Saikat, additional, Knafl, Mark, additional, Edelkamp, Paul, additional, Ito, Ichiaki, additional, Gu, Yue, additional, Pattalachinti, Vinay, additional, Naini, Zahra Alavi, additional, Zeineddine, Fadl A., additional, Peterson, Jennifer, additional, Alfaro, Kristin, additional, Foo, Wai Chin, additional, Jin, Jeff, additional, Bhutiani, Neal, additional, Higbie, Victoria, additional, Scally, Christopher P., additional, Kee, Bryan, additional, Kopetz, Scott, additional, Goldstein, Drew, additional, Strach, Madeleine, additional, Williamson, Andrew, additional, Aziz, Omer, additional, Barriuso, Jorge, additional, Uppal, Abhineet, additional, White, Michael G., additional, Helmink, Beth, additional, Fournier, Keith F., additional, Raghav, Kanwal P., additional, Taggart, Melissa W., additional, Overman, Michael J., additional, and Shen, John Paul, additional

Published
2024
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31. Risk of relapse after surgical resection of localized appendiceal adenocarcinoma.

Author

Fanaeian, Mohammad Mahdi, primary, Yousef, Mahmoud M.G., additional, Yousef, Abdelrahman M.G., additional, Foo, Wai Chin, additional, Taggart, Melissa, additional, Beaty, Karen A., additional, Scally, Christopher, additional, Mansfield, Paul F., additional, Fournier, Keith F., additional, Helmink, Beth A, additional, and Shen, John Paul Y.C., additional

Published
2024
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32. Peritoneal Microenvironment Promotes Appendiceal Adenocarcinoma Growth: A Multi-omics Approach Using Patient-Derived Xenografts

Author

Pattalachinti, Vinay K., primary, Ito, Ichiaki, additional, Chowdhury, Saikat, additional, Yousef, Abdelrahman, additional, Gu, Yue, additional, Gunes, Betul Beyza, additional, Salle, Emma R., additional, Taggart, Melissa, additional, Fournier, Keith, additional, Fowlkes, Natalie W., additional, and Shen, John Paul, additional

Published
2024
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35. Repeat Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Recurrent Mucinous Appendiceal Adenocarcinoma: A Viable Treatment Strategy with Demonstrable Benefit

Author

Bhutiani, Neal, primary, Grotz, Travis E., additional, Concors, Seth J., additional, White, Michael G., additional, Helmink, Beth A., additional, Raghav, Kanwal P., additional, Taggart, Melissa W., additional, Beaty, Karen A., additional, Royal, Richard E., additional, Overman, Michael J., additional, Matamoros, Aurelio, additional, Scally, Christopher P., additional, Rafeeq, Safia, additional, Mansfield, Paul F., additional, and Fournier, Keith F., additional

Published
2023
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36. The Clinical Significance of CEA, CA19-9, and CA125 in Management of Appendiceal Adenocarcinoma

Author

Yousef, Abdelrahman, primary, Yousef, Mahmoud, additional, Zeineddine, Mohammad, additional, More, Aditya, additional, Chowdhury, Saikat, additional, Knafl, Mark, additional, Edelkamp, Paul, additional, Ito, Ichiaki, additional, Gu, Yue, additional, Pattalachinti, Vinay, additional, Naini, Zahra Alavi, additional, Zeineddine, Fadl, additional, Peterson, Jennifer, additional, Alfaro, Kristin, additional, Foo, Wai Chin, additional, Jin, Jeff, additional, Bhutiani, Neal, additional, Higbie, Victoria, additional, Scally, Christopher, additional, Kee, Bryan, additional, Kopetz, Scott, additional, Goldstein, Drew, additional, Uppal, Abhineet, additional, White, Michael G., additional, Helmink, Beth, additional, Fournier, Keith, additional, Raghav, Kanwal, additional, Taggart, Melissa, additional, Overman, Michael J., additional, and Shen, John Paul, additional

Published
2023
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38. Efficacy of Systemic Chemotherapy in Patients With Low-grade Mucinous Appendiceal Adenocarcinoma

Author

Shen, John Paul, primary, Yousef, Abdelrahman M., additional, Zeineddine, Fadl A., additional, Zeineddine, Mohammad A., additional, Tidwell, Rebecca S., additional, Beaty, Karen A., additional, Scofield, Lisa C., additional, Rafeeq, Safia, additional, Hornstein, Nicholas, additional, Lano, Elizabeth, additional, Eng, Cathy, additional, Matamoros, Aurelio, additional, Foo, Wai Chin, additional, Uppal, Abhineet, additional, Scally, Christopher, additional, Mansfield, Paul, additional, Taggart, Melissa, additional, Raghav, Kanwal P., additional, Overman, Michael J., additional, and Fournier, Keith, additional

Published
2023
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39. Colorectal surveillance outcomes from an institutional longitudinal cohort of lynch syndrome carriers

Author

del Carmen, Gabriel, primary, Reyes-Uribe, Laura, additional, Goyco, Daniel, additional, Evans, Kyera, additional, Bowen, Charles M., additional, Kinnison, Jennifer L., additional, Sepeda, Valerie O., additional, Weber, Diane M., additional, Moskowitz, Julie, additional, Mork, Maureen E., additional, Thirumurthi, Selvi, additional, Lynch, Patrick M., additional, Rodriguez-Bigas, Miguel A., additional, Taggart, Melissa W., additional, You, Y. Nancy, additional, and Vilar, Eduardo, additional

Published
2023
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40. Figure S1 from In Silico Systems Biology Analysis of Variants of Uncertain Significance in Lynch Syndrome Supports the Prioritization of Functional Molecular Validation

Author

Borras, Ester, primary, Chang, Kyle, primary, Pande, Mala, primary, Cuddy, Amanda, primary, Bosch, Jennifer L., primary, Bannon, Sarah A., primary, Mork, Maureen E., primary, Rodriguez-Bigas, Miguel A., primary, Taggart, Melissa W., primary, Lynch, Patrick M., primary, You, Y. Nancy, primary, and Vilar, Eduardo, primary

Published
2023
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41. Supplementary Tables from Combination of Sulindac and Bexarotene for Prevention of Intestinal Carcinogenesis in Familial Adenomatous Polyposis

Author

Bowen, Charles M., primary, Walter, Lewins, primary, Borras, Ester, primary, Wu, Wenhui, primary, Ozcan, Zuhal, primary, Chang, Kyle, primary, Bommi, Prashant V., primary, Taggart, Melissa W., primary, Thirumurthi, Selvi, primary, Lynch, Patrick M., primary, Reyes-Uribe, Laura, primary, Scheet, Paul A., primary, Sinha, Krishna M., primary, and Vilar, Eduardo, primary

Published
2023
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42. Supplementary Tables S1-S15 from In Silico Systems Biology Analysis of Variants of Uncertain Significance in Lynch Syndrome Supports the Prioritization of Functional Molecular Validation

Author

Borras, Ester, primary, Chang, Kyle, primary, Pande, Mala, primary, Cuddy, Amanda, primary, Bosch, Jennifer L., primary, Bannon, Sarah A., primary, Mork, Maureen E., primary, Rodriguez-Bigas, Miguel A., primary, Taggart, Melissa W., primary, Lynch, Patrick M., primary, You, Y. Nancy, primary, and Vilar, Eduardo, primary

Published
2023
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43. Data from In Silico Systems Biology Analysis of Variants of Uncertain Significance in Lynch Syndrome Supports the Prioritization of Functional Molecular Validation

Author

Borras, Ester, primary, Chang, Kyle, primary, Pande, Mala, primary, Cuddy, Amanda, primary, Bosch, Jennifer L., primary, Bannon, Sarah A., primary, Mork, Maureen E., primary, Rodriguez-Bigas, Miguel A., primary, Taggart, Melissa W., primary, Lynch, Patrick M., primary, You, Y. Nancy, primary, and Vilar, Eduardo, primary

Published
2023
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44. Supplementary Figures from Combination of Sulindac and Bexarotene for Prevention of Intestinal Carcinogenesis in Familial Adenomatous Polyposis

Author

Bowen, Charles M., primary, Walter, Lewins, primary, Borras, Ester, primary, Wu, Wenhui, primary, Ozcan, Zuhal, primary, Chang, Kyle, primary, Bommi, Prashant V., primary, Taggart, Melissa W., primary, Thirumurthi, Selvi, primary, Lynch, Patrick M., primary, Reyes-Uribe, Laura, primary, Scheet, Paul A., primary, Sinha, Krishna M., primary, and Vilar, Eduardo, primary

Published
2023
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45. Supplementary Tables S1-S9 from Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis

Author

Gausachs, Mireia, primary, Borras, Ester, primary, Chang, Kyle, primary, Gonzalez, Sara, primary, Azuara, Daniel, primary, Delgado Amador, Axel, primary, Lopez-Doriga, Adriana, primary, San Lucas, F. Anthony, primary, Sanjuan, Xavier, primary, Paules, Maria J., primary, Taggart, Melissa W., primary, Davies, Gareth E., primary, Ehli, Erik A., primary, Fowler, Jerry, primary, Moreno, Victor, primary, Pineda, Marta, primary, You, Y. Nancy, primary, Lynch, Patrick M., primary, Lazaro, Conxi, primary, Navin, Nicholas E., primary, Scheet, Paul A., primary, Hawk, Ernest T., primary, Capella, Gabriel, primary, and Vilar, Eduardo, primary

Published
2023
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47. Supplementary Figures S1-S15 from Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis

Author

Gausachs, Mireia, primary, Borras, Ester, primary, Chang, Kyle, primary, Gonzalez, Sara, primary, Azuara, Daniel, primary, Delgado Amador, Axel, primary, Lopez-Doriga, Adriana, primary, San Lucas, F. Anthony, primary, Sanjuan, Xavier, primary, Paules, Maria J., primary, Taggart, Melissa W., primary, Davies, Gareth E., primary, Ehli, Erik A., primary, Fowler, Jerry, primary, Moreno, Victor, primary, Pineda, Marta, primary, You, Y. Nancy, primary, Lynch, Patrick M., primary, Lazaro, Conxi, primary, Navin, Nicholas E., primary, Scheet, Paul A., primary, Hawk, Ernest T., primary, Capella, Gabriel, primary, and Vilar, Eduardo, primary

Published
2023
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48. Supplementary Figures + Legend from Optimized Doxorubicin Chemotherapy for Diffuse Large B-cell Lymphoma Exploits Nanocarrier Delivery to Transferrin Receptors

Author

Arumov, Artavazd, primary, Liyanage, Piumi Y., primary, Trabolsi, Asaad, primary, Roberts, Evan R., primary, Li, Lingxiao, primary, Ferreira, Braulio C.L.B., primary, Gao, Zhen, primary, Ban, Yuguang, primary, Newsam, Austin D., primary, Taggart, Melissa W., primary, Vega, Francisco, primary, Bilbao, Daniel, primary, Leblanc, Roger M., primary, and Schatz, Jonathan H., primary

Published
2023
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49. Supplementary Material and Methods from The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells

Author

Bommi, Prashant V., primary, Bowen, Charles M., primary, Reyes-Uribe, Laura, primary, Wu, Wenhui, primary, Katayama, Hiroyuki, primary, Rocha, Pedro, primary, Parra, Edwin R., primary, Francisco-Cruz, Alejandro, primary, Ozcan, Zuhal, primary, Tosti, Elena, primary, Willis, Jason A., primary, Wu, Hong, primary, Taggart, Melissa W., primary, Burks, Jared K., primary, Lynch, Patrick M., primary, Edelmann, Winfried, primary, Scheet, Paul A., primary, Wistuba, Ignacio I., primary, Sinha, Krishna M., primary, Hanash, Samir M., primary, and Vilar, Eduardo, primary

Published
2023
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50. Supplementary Figures S1-S6 from The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells

Author

Bommi, Prashant V., primary, Bowen, Charles M., primary, Reyes-Uribe, Laura, primary, Wu, Wenhui, primary, Katayama, Hiroyuki, primary, Rocha, Pedro, primary, Parra, Edwin R., primary, Francisco-Cruz, Alejandro, primary, Ozcan, Zuhal, primary, Tosti, Elena, primary, Willis, Jason A., primary, Wu, Hong, primary, Taggart, Melissa W., primary, Burks, Jared K., primary, Lynch, Patrick M., primary, Edelmann, Winfried, primary, Scheet, Paul A., primary, Wistuba, Ignacio I., primary, Sinha, Krishna M., primary, Hanash, Samir M., primary, and Vilar, Eduardo, primary

Published
2023
Full Text
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