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Objectives: The objective is to evaluate the feasibility and safety of ArtiSential for performing minimally invasive surgeries for gynecological cancers. Materials and Methods: We conducted a prospective observational study at 10 Tertiary Institutional Hospitals in Korea between November 2021 and April 2022. Eligible patients were 18 years or older and planned to undergo minimally invasive surgery for gynecologic cancer. We collected baseline characteristics, surgical information, and postoperative outcomes. The primary endpoint was to compare the operation time required for gynecologic cancer surgery using ArtiSential with the reported operation time for surgery using conventional laparoscopic instruments or robots. The secondary endpoints were to evaluate the surgical outcomes of gynecologic cancer surgery using ArtiSential compared to conventional laparoscopic instruments or robots and collect operator feedback on equipment improvements during surgery. Results: Forty patients were enrolled in this study, including 19 with endometrial cancer, 15 with cervical cancer, and 6 with ovarian cancer. The average operation time was 187.0 ± 49.2 min, with no complications encountered during surgery. Pelvic lymph nodes were assessed in 34 patients, with the ArtiSential device utilized in 22 (64.7%) of these patients, at an average assessment time of 40.3 ± 19.4 min. Most surgeons using the ArtiSential device reported that it performed slightly better than conventional laparoscopic instruments. Conclusion: The use of the ArtiSential device in minimally invasive surgery has been demonstrated to be both feasible and safe for the treatment of early-stage gynecologic cancer.

Abstract Q-balls are non-topological solitons in field theories whose stability is typically guaranteed by the existence of a global conserved charge. A classic realization is the Friedberg-Lee-Sirlin (FLS) Q-ball in a two-scalar system where a real scalar χ triggers symmetry breaking and confines a complex scalar Φ with a global U(1) symmetry. A quartic interaction κχ 2|Φ|2 with κ > 0 is usually considered to produce a nontrivial Q-ball configuration, and this repulsive force contributes to its stability. On the other hand, the attractive cubic interaction Λχ|Φ|2 is generally allowed in a renormalizable theory and could induce an instability. In this paper, we study the behavior of the Q-ball under the influence of this attractive force which has been overlooked. We find approximate Q-ball solutions in the limit of weak and moderate force couplings using the thin-wall and thick-wall approximations respectively. Our analytical results are consistent with numerical simulations and predict the parameter dependencies of the maximum charge. A crucial difference with the ordinary FLS Q-ball is the existence of the maximum charge beyond which the Q-ball solution is classically unstable. Such a limitation of the charge fundamentally affects Q-ball formation in the early Universe and could plausibly lead to the formation of primordial black holes.

Abstract Accurate measurement of abdominal aortic aneurysm is essential for selecting suitable stent-grafts to avoid complications of endovascular aneurysm repair. However, the conventional image-based measurements are inaccurate and time-consuming. We introduce the automated workflow including semantic segmentation with active learning (AL) and measurement using an application programming interface of computer-aided design. 300 patients underwent CT scans, and semantic segmentation for aorta, thrombus, calcification, and vessels was performed in 60–300 cases with AL across five stages using UNETR, SwinUNETR, and nnU-Net consisted of 2D, 3D U-Net, 2D-3D U-Net ensemble, and cascaded 3D U-Net. 7 clinical landmarks were automatically measured for 96 patients. In AL stage 5, 3D U-Net achieved the highest dice similarity coefficient (DSC) with statistically significant differences (p

Abstract Accurate lesion diagnosis through computed tomography (CT) and advances in laparoscopic or robotic surgeries have increased partial nephrectomy survival rates. However, accurately marking the kidney resection area through the laparoscope is a prevalent challenge. Therefore, we fabricated and evaluated a 4D-printed kidney surgical guide (4DP-KSG) for laparoscopic partial nephrectomies based on CT images. The kidney phantom and 4DP-KSG were designed based on CT images from a renal cell carcinoma patient. 4DP-KSG were fabricated using shape-memory polymers. 4DP-KSG was compressed to a 10 mm thickness and restored to simulate laparoscopic port passage. The Bland–Altman evaluation assessed 4DP-KSG shape and marking accuracies before compression and after restoration with three operators. The kidney phantom’s shape accuracy was 0.436 ± 0.333 mm, and the 4DP-KSG’s shape accuracy was 0.818 ± 0.564 mm before compression and 0.389 ± 0.243 mm after restoration, with no significant differences. The 4DP-KSG marking accuracy was 0.952 ± 0.682 mm before compression and 0.793 ± 0.677 mm after restoration, with no statistical differences between operators (p = 0.899 and 0.992). In conclusion, our 4DP-KSG can be used for laparoscopic partial nephrectomies, providing precise and quantitative kidney tumor marking between operators before compression and after restoration.

Abstract Partial nephrectomy has been demonstrated to preserve renal function compared with radical nephrectomy. Computed tomography (CT) is used to reveal localized renal cell carcinoma (RCC). However, marking RCC directly and quantitatively on a patient's kidney during an operation is difficult. We fabricated and evaluated a 3D-printed kidney surgical guide (3DP-KSG) with a realistic kidney phantom. The kidney phantoms including parenchyma and three different RCC locations and 3DP-KSG were designed and fabricated based on a patient's CT image. 3DP-KSG was used to insert 16-gauge intravenous catheters into the kidney phantoms, which was scanned by CT. The catheter insertion points and angle were evaluated. The measurement errors of insertion points were 1.597 ± 0.741 mm, and cosine similarity of trajectories was 0.990 ± 0.010. The measurement errors for X-axis, Y-axis, and Z-axis in the insertion point were 0.611 ± 0.855 mm, 0.028 ± 1.001 mm, and − 0.510 ± 0.923 mm. The 3DP-KSG targeted the RCC accurately, quantitatively, and immediately on the surface of the kidney, and no significant difference was shown between the operators. Partial nephrectomy will accurately remove the RCC using 3DP-KSG in the operating room.

The color conversion efficiency of phosphor films can be significantly improved by producing them in the shape of photonic crystals (PhCs). When light with photonic band‐edge wavelengths is incident on a PhCs phosphor film, the excitation photons are resonantly absorbed, enhancing the emission intensity. This study develops three‐dimensional PhC phosphor films based on self‐assembled inverse opal structures. PhC phosphors are constructed using a silk fibroin polymer and red organic fluorescent dyes (λpeak ≈ 610 nm) doped into it. The photonic structures are designed using electromagnetic wave simulations and photonic band structure analyses. The fabricated PhC phosphor films are integrated with blue micro‐light‐emitting diode (micro‐LED) chips (λpeak ≈ 452 nm), resulting in a color conversion efficiency increase of more than 1.5 times that of bulk phosphor films. Additionally, experiments are performed using various micro‐LED chips with a size of less than 100 μm. Overall, the results of this study demonstrate the potential of PhC phosphor films in future micro‐LED‐based devices and applications, including displays and communication systems.

Offshore wind power has attracted significant attention due to its high potential, capability for large-scale farms, and high capacity factor. However, it faces high investment costs and issues with subsea power transmission. Conventional high-voltage AC (HVAC) methods are limited by charging current, while high-voltage DC (HVDC) methods suffer from the high cost of power conversion stations. The low-frequency AC (LFAC) method mitigates the charging current through low-frequency operation and can reduce power conversion station costs. This paper aims to identify the economically optimal frequency by comparing the investment costs of LFAC systems at various frequencies. The components of LFAC, including transformers, offshore platforms, and cables, exhibit frequency-dependent characteristics. Lower frequencies result in an increased size and volume of transformers, leading to higher investment costs for offshore platforms. In contrast, cable charging currents and losses are proportional to frequency, causing the total cost to reach a minimum at a specific frequency. To determine the optimal frequency, simulations of investment costs for varying capacities and distances were conducted.

A biotope map provides ecological and spatial information that reflects the natural and ecological features and values of a city. In South Korea, efforts have been made to create a map that includes grades based on evaluating the ecological value of a specific surface space. However, plans for applications have not been established, except for development restrictions or regulations for biotopes with high ecological value ratings. The aim of this study was to promote environmentally friendly and sustainable urban management through ecological land use management for all biotope types that are influenced by anthropogenic land use. Strategies for maintenance, protection, recovery, improvement, creation, and reduction based on ecological restoration principles were set as management goals. To achieve these management goals, evaluation items and indicators were suggested for minor-classification types and applied to Dongducheon City. Management strategies were suggested for target sites based on grades and thematic maps of biotope types to be utilized, such as urban ecological axes, river naturality restoration, and wetland and forest preservation. These findings support sustainable and environmentally friendly urban development by providing fundamental data for ecological and environmental management, including the preservation and restoration of natural environments and the creation of urban ecological networks.

Abstract Argyrodite‐type Li6PS5Cl (LPSCl) has attracted much attention as a solid electrolyte for all‐solid‐state batteries (ASSBs) because of its high ionic conductivity and good mechanical flexibility. LPSCl, however, has challenges of translating research into practical applications, such as irreversible electrochemical degradation at the interface between LPSCl and cathode materials. Even for Li‐ion batteries (LIBs), liquid electrolytes have the same issue as electrolyte decomposition due to interfacial instability. Nonetheless, current LIBs are successfully commercialized because functional electrolyte additives give rise to the formation of stable cathode‐electrolyte interphase (CEI) and solid‐electrolyte interphase (SEI) layers, leading to supplementing the interfacial stability between electrolyte and electrode. Herein, inspired by the role of electrolyte additives for LIBs, trimethylsilyl compounds are introduced as solid electrolyte additives for improving the interfacial stability between sulfide‐based solid electrolytes and cathode materials. 2‐(Trimethylsilyl)ethanethiol (TMS‐SH), a solid electrolyte additive, is oxidatively decomposed during charge, forming a stable CEI layer. As a result, the CEI layer derived from TMS‐SH suppresses the interfacial degradation between LPSCl and LiCoO2, thereby leading to the excellent electrochemical performance of Li | LPSCl | LiCoO2, such as superior cycle life over 2000 cycles (85.0% of capacity retention after 2000 cycles).

Although attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder, it is difficult to develop an accurate diagnostic method. Recently, studies to classify ADHD using resting-state functional magnetic resonance (rs-fMRI) imaging data have been conducted with the development of computing resources and machine learning techniques. Most of them use the entire brain’s regions when training the models. As opposed to the common approach, we conducted a study to classify ADHD by selecting essential areas for using a deep learning model. The experiment used rs-fMRI data from the ADHD-200 global competition. To obtain an integrated result from the multiple sites, each region of the brain is evaluated using ’leave- one-site-out’ cross-validation. As a result, when we only used 15 important regions of interest (ROIs) for training, 70.6% accuracy was obtained, significantly exceeding the existing results of 68.6% from all ROIs. Additionally, to explore the new structure based on SCCNN-RNN, we performed the same experiment with three modified models: (1) separate channel CNN - RNN with attention (ASCRNN), (2) separate channel dilate CNN - RNN with attention (ASDRNN), (3) separate channel CNN - slicing RNN with attention (ASSRNN). The ASSRNN model provides a high accuracy of 70.46% when trained with only 13 important ROIs. These results show that using deep learning to identify the crucial parts of the brain in diagnosing ADHD yields better results than using every area.

Abstract Recently, the development of 3D printing (3DP) technology and its application in various fields have improved our quality of life. However, hazardous materials that affect the human body, such as formaldehyde and particulate matter (PM), are emitted into the air during 3DP. This study measured the formaldehyde, PM10, and PM2.5 emitted by 3DP with the ventilation operation using six materials in material extrusion (ME) and vat photopolymerization (VP) and compared them between the 3DP workspace and the control setting with test–retest validation by two researchers. The experiments were divided into four stages based on the 3DP and ventilation operation. A linear mixed model was used to analyze the mean differences and tendencies between the 3DP workspace and the control setting. The change as ventilation was switched from off to on was evaluated by calculating the area. The differences and tendencies were shown in the statistically significant differences from a post-hoc test (α = 0.0125) except for some cases. There was a significant difference in formaldehyde depending on the ventilation operation; however, only a minor difference in PM10, and PM2.5 was confirmed. The amount of formaldehyde exceeding the standard was measured in all materials during 3DP without ventilation. Therefore, it is recommended to operate ventilation systems.

Abstract The aim of this study was to develop an auto-segmentation algorithm for mandibular condyle using the 3D U-Net and perform a stress test to determine the optimal dataset size for achieving clinically acceptable accuracy. 234 cone-beam computed tomography images of mandibular condyles were acquired from 117 subjects from two institutions, which were manually segmented to generate the ground truth. Semantic segmentation was performed using basic 3D U-Net and a cascaded 3D U-Net. A stress test was performed using different sets of condylar images as the training, validation, and test datasets. Relative accuracy was evaluated using dice similarity coefficients (DSCs) and Hausdorff distance (HD). In the five stages, the DSC ranged 0.886–0.922 and 0.912–0.932 for basic 3D U-Net and cascaded 3D U-Net, respectively; the HD ranged 2.557–3.099 and 2.452–2.600 for basic 3D U-Net and cascaded 3D U-Net, respectively. Stage V (largest data from two institutions) exhibited the highest DSC of 0.922 ± 0.021 and 0.932 ± 0.023 for basic 3D U-Net and cascaded 3D U-Net, respectively. Stage IV (200 samples from two institutions) had a lower performance than stage III (162 samples from one institution). Our results show that fully automated segmentation of mandibular condyles is possible using 3D U-Net algorithms, and the segmentation accuracy increases as training data increases.

Data-driven fault diagnosis is an essential technology for the safety and maintenance of rock drills. However, since the signals acquired from a rock drill have different distributions, which arise due to their variable operating conditions, the classification performance of any data-driven method is diminished; this is called the domain-shift issue. This paper proposes a new domain-adaptation-based fault diagnosis scheme to solve the domain-shift problem. The proposed method introduces a data-cropping technique to mitigate the difference in the length of the data measured from a rock drill for each impact cycle. To extract invariant features for all operating conditions, the proposed method combines two methods: a domain adversarial neural network and minimization of the maximum mean discrepancy (MMD) between the features from different domains. In addition, a soft voting ensemble is used to reduce the model uncertainty. The proposed method shows superior performance when validated with a rock drill dataset; the proposed approach was ranked in 2nd place in the 2022 PHM Conference Data Challenge.

Robust and accurate three-dimensional localization is essential for personal navigation, emergency rescue, and worker monitoring in indoor environments. For localization technology to be employed in various applications, it is necessary to reduce infrastructure dependence and limit the maximum error bound. This study aims to accurately estimate the location of various people using smartphones in a building with a cloud platform-based localization system. The proposed technology is modularized in a hierarchical structure to sequentially estimate the floor and location. This system comprises four localization modules: course level detection, fine level detection (FLD), fine location tracking (FLT), and level change detection (LCD). Each module operates organically according to the current user status. The position estimation range is defined as a total of three phases, and an appropriate location estimation module suitable for the corresponding phase operates to estimate the user’s location gradually and precisely. When the user’s floor is determined by an FLD, the two-dimensional position of the user is estimated by an FLT module that tracks the user’s position by comparing the received signal strength indicator vector sequence and radio map. Also, LCD recognizes the user’s floor change and converts the user’s phase. To verify the proposed technology, various experiments were conducted in a six-story building, and an average accuracy of less than 2 m was obtained.

The use of nuclear energy is inevitable to reduce the dependence on fossil fuels in the energy sector. High-temperature gas-cooled reactors (HTGRs) are considered as a system suitable for the purpose of reducing the use of fossil fuels. Furthermore, eco-friendly mass production of hydrogen is crucial because hydrogen is emerging as a next-generation energy carrier. The unit cost of hydrogen production by the levelized cost of energy (LCOE) method varies widely depending on the energy source and system configuration. In this study, energy, exergy, and thermoeconomic analyses were performed on the hydrogen production system using the HTGR and high-temperature water-cooled nuclear reactor (HTWR) to calculate reasonable unit cost of the hydrogen produced using a thermoeconomic method called modified production structure analysis (MOPSA). A flowsheet analysis was performed to confirm the energy conservation in each component. The electricity generated from the 600 MW HTGR system was used to produce 1.28 kmol/s of hydrogen by electrolysis to split hot water vapor. Meanwhile, 515 MW of heat from the 600 MW HTWR was used to produce 8.10 kmol/s of hydrogen through steam reforming, and 83.6 MW of electricity produced by the steam turbine was used for grid power. The estimated unit cost of hydrogen from HTGR is approximately USD 35.6/GJ with an initial investment cost of USD 2.6 billion. If the unit cost of natural gas is USD 10/GJ, and the carbon tax is USD 0.08/kg of carbon dioxide, the unit cost of hydrogen produced from HTWR is approximately USD 13.92/GJ with initial investment of USD 2.32 billion. The unit cost of the hydrogen produced in the scaled-down plant was also considered.

The 2D semimetallic electrodes have been employed to show outstanding contact properties with 2D semiconducting transition‐metal dichalcogenides (TMDCs) channel, leading to large enhancement of 2D transistor and phototransistor performance. Herein, an innovative concept is established for a unique 2D semimetallic electrode‐2D TMDC channel (2D–2D) device configuration where the electronic structures of 2D semimetallic electrodes are systematically modulated to improve the contact properties with 2D monolayer molybdenum disulfide (MoS2) channel. The 2D semimetallic copper sulfide (CuS) electrodes are doped with iodine atoms by a direct exposure of iodine gas. The contact properties and charge‐transport behavior in the 2D–2D field‐effect transistors (FETs) are highly improved, which is attributed to the favorable energy band alignment and associated material properties between the iodine‐doped CuS (CuS–I) electrodes and 2D channel. The 2D–2D FETs show a high on current, high on/off ratio, and twofold improvement in mobility. Furthermore, 2D–2D phototransistors and flexible/transparent photodetectors are fabricated using the CuS–I/MoS2, which also performed outstanding photoresponsivity characteristics and mechanical durability under external bending strain conditions. These findings demonstrate a promising pathway that under the 2D–2D configuration, the electronic modulation by the iodine atoms may enable the development of future 2D electronic applications.

Abstract Background The Laparoscopic Approach to Cervical Cancer trial and Surveillance, Epidemiology, and End Results program database study demonstrated that minimally invasive radical hysterectomy was inferior to abdominal radical hysterectomy in terms of disease recurrence and survival. Among risk factors related to poor prognosis after minimally invasive surgery (MIS), tumour spillage during intracorporeal colpotomy became a significant issue. Thus, we designed this trial to evaluate the efficacy and safety of minimally invasive radical hysterectomy using an endoscopic stapler for early-stage cervical cancer. Methods This trial is a prospective, multi-centre, open-label, single-arm, non-inferiority phase II study. The nine organisations will participate in this trial after the approval of the institutional review board. Major eligibility criteria include women aged 20 years or older with cervical cancer stage IB1 squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma according to the revised 2009 FIGO staging system who will undergo type B2 or C hysterectomy by MIS. The primary endpoint is the 4.5-year disease-free survival (DFS) rate between abdominal radical hysterectomy and MIS using an endoscopic stapler. For calculating the sample size, we hypothesised that the 4.5-year DFS rate after MIS using an endoscopic stapler is assumed to be the same after abdominal radical hysterectomy at 90.9%, and the non-inferiority margin was 7.2%. When we consider a three-year accrual and 4.5-year follow-up, at least 13 events must happen, requiring a total of 111 patients assuming a statistical power of 80% and the one-tailed test of 5% significance. A total of 124 patients is needed, considering a drop-out rate of 10%. Discussion We expect intracorporeal colpotomy using an endoscopic stapler may prevent tumour spillage during MIS for stage IB1 cervical cancer, showing a comparable prognosis with abdominal radical surgery. Trial registration ClinicalTrials.gov ; NCT04370496 ; registration date, May 2020.

Modern OSs expose an interface for monitoring CPU temperature to unprivileged users for effective user decision-based thermal management. Due to the low sampling rate and resolution, thermal sensors have generally been restricted to the construction of covert channels. However, exposing the thermal interface to unprivileged users may be problematic, because the heat emission inside a CPU core is affected by program execution on the core; an attacker may be able to infer the secret information of the program by exploiting the thermal interface as a side-channel. In this paper, we extensively analyze digital thermal sensors in Intel CPUs and show that it is possible to implement a software-based thermal side-channel attack. Specifically, by analyzing some properties of the thermal sensors, we inferred that the thermal sensor makes it possible to distinguish between a cache hit and a physical memory access in memory load operations. Based on the analysis results, we implement ThermalBleed, a thermal side-channel attack that breaks kernel address space layout randomization (KASLR) in Linux systems. Moreover, by conducting an in-depth analysis, we identify useful hidden properties of the Intel thermal sensors. Our analysis establishes a stepping stone to build a more precise and effective thermal side-channel attack in the future. To the best of our knowledge, this is the first work that extends a thermal covert channel to a practical side-channel attack by exploring the properties of Intel digital thermal sensors.

How can we recommend existing bundles to users accurately? How can we generate new tailored bundles for users? Recommending a bundle, or a group of various items, has attracted widespread attention in e-commerce owing to the increased satisfaction of both users and providers. Bundle matching and bundle generation are two representative tasks in bundle recommendation. The bundle matching task is to correctly match existing bundles to users while the bundle generation is to generate new bundles that users would prefer. Although many recent works have developed bundle recommendation models, they fail to achieve high accuracy since they do not handle heterogeneous data effectively and do not learn a method for customized bundle generation. In this paper, we propose BundleMage, an accurate approach for bundle matching and generation. BundleMage effectively mixes user preferences of items and bundles using an adaptive gate technique to achieve high accuracy for the bundle matching. BundleMage also generates a personalized bundle by learning a generation module that exploits a user preference and the characteristic of a given incomplete bundle to be completed. BundleMage further improves its performance using multi-task learning with partially shared parameters. Through extensive experiments, we show that BundleMage achieves up to 6.6% higher nDCG in bundle matching and 6.3× higher nDCG in bundle generation than the best competitors. We also provide qualitative analysis that BundleMage effectively generates bundles considering both the tastes of users and the characteristics of target bundles.

The Verwey transition in magnetite has been studied for nearly eight decades since its discovery in the 1940s. Here, Kim et al. elucidate the influence of chemical doping by extremely slow oxidization process with magnetite nanoparticles, revealing why first- and second-order regimes of the Verwey transition are observed.

Abstract In thoracoabdominal aortic aneurysm repair, repairing the visceral and segmental arteries is challenging. Although there is a pre-hand-sewn and multi-branched graft based on the conventional image-based technique, it has shortcomings in precisely positioning and directing the visceral and segmental arteries. Here, we introduce two new reconstruction techniques using patient-specific 3D-printed graft reconstruction guides: (1) model-based technique that presents the projected aortic graft, visualizing the main aortic body and its major branches and (2) guide-based technique in which the branching vessels in the visualization model are replaced by marking points identifiable by tactile sense. We demonstrate the effectiveness by evaluating conventional and new techniques based on accuracy, marking time requirement, reproducibility, and results of survey to surgeons on the perceived efficiency and efficacy. The graft reconstruction guides cover the segmentation, design, fabrication, post-processing, and clinical application of open surgical repair of thoracoabdominal aneurysm, and proved to be efficient for accurately reconstructing customized grafts.

In geometrically frustrated magnets small perturbations, such as non-magnetic impurities, can significantly alter the ground state. Here, using inelastic neutron scattering, Park et al. explore such a situation in Al-doped h-YMnO3, where the Aluminum dopants induce an extended spin structure.

Abstract Herein, realistic and reusable phantoms for simulation of pediatric lung video-assisted thoracoscopic surgery (VATS) were proposed and evaluated. 3D-printed phantoms for VATS were designed based on chest computed tomography (CT) data of a pediatric patient with esophageal atresia and tracheoesophageal fistula. Models reflecting the patient-specific structure were fabricated based on the CT images. Appropriate reusable design, realistic mechanical properties with various material types, and 3D printers (fused deposition modeling (FDM) and PolyJet printers) were used to represent the realistic anatomical structures. As a result, the phantom printed by PolyJet reflected closer mechanical properties than those of the FDM phantom. Accuracies (mean difference ± 95 confidence interval) of phantoms by FDM and PolyJet were 0.53 ± 0.46 and 0.98 ± 0.55 mm, respectively. Phantoms were used by surgeons for VATS training, which is considered more reflective of the clinical situation than the conventional simulation phantom. In conclusion, the patient-specific, realistic, and reusable VATS phantom provides a better understanding the complex anatomical structure of a patient and could be used as an educational phantom for esophageal structure replacement in VATS.

Overhead lines that are exposed to the outdoors are susceptible to faults such as open conductors on weak points and disconnection caused by external factors such as typhoons. Arcs that occur during disconnection generate energy at a high heat of over 10,000 °C, requiring swift fault shut-off. However, most conventional fault detection methods to protect electrical power systems detect an overcurrent; thus, they can only detect faults after the line is disconnected and the cross-section of the line that generates the arc discharge makes contact with another line or the ground, causing a high risk of fire. Furthermore, in the case of ground faults owing to the disconnection of overhead lines, the load and the grounding impedance are not parallel. Therefore, in the case of the fault current not exceeding the threshold or a high impedance fault due to the high grounding impedance of the surrounding environment, such as grass or trees, it is difficult to determine overhead line faults with conventional fault detection methods. To solve these issues, this paper proposes an AI-based open conductor fault detection method on overhead lines that can clear the fault before the falling open conductor line comes into contact with the ground’s surface so as to prevent fire. The falling time according to the height and span of the overhead line was calculated using a falling conductor model for the overhead line, to which the pendulum motion was applied. The optimal input data cycle that enables fault detection before a line–ground fault occurs was derived. For artificial intelligence learning to prevent wildfires, the voltage and current signals were collected through a total of 432 fault simulations and were wavelet-transformed with a deep neural network to verify the method. The proposed total scheme was simulated and verified with MATLAB.

Solar-to-steam (STS) generation based on plasmonic materials has attracted significant attention as a green method for producing fresh water. Herein, a simple in situ method is introduced to fabricate Au nanoparticles (AuNPs) on cellulose filter papers as dual-functional substrates for STS generation and surface-enhanced Raman spectroscopy (SERS) sensing. The substrates exhibit 90% of broadband solar absorption between 350 and 1800 nm and achieve an evaporation rate of 0.96 kg·m−2·h−1 under 1-sun illumination, room temperature of 20 °C, and relative humidity of 40%. The STS generation of the substrate is stable during 30 h continuous operation. Enriched SERS hotspots between AuNPs endow the substrates with the ability to detect chemical contamination in water with ppb limits of detection for rhodamine 6G dye and melamine. To demonstrate dual-functional properties, the contaminated water was analyzed with SERS and purified by STS. The purified water was then analyzed with SERS to confirm its purity. The developed substrate can be an improved and suitable candidate for fresh water production and qualification.

Small molecule modulators of mitochondrial function have been attracted much attention in recent years due to their potential therapeutic applications for neurodegenerative diseases. The mitochondrial translocator protein (TSPO) is a promising target for such compounds, given its involvement in the formation of the mitochondrial permeability transition pore in response to mitochondrial stress. In this study, we performed a ligand-based pharmacophore design and virtual screening, and identified a potent hit compound, 7 (VH34) as a TSPO ligand. After validating its biological activity against amyloid-β (Aβ) induced mitochondrial dysfunction and in acute and transgenic Alzheimer’s disease (AD) model mice, we developed a library of analogs, and we found two most active compounds, 31 and 44, which restored the mitochondrial membrane potential, ATP production, and cell viability under Aβ-induced mitochondrial toxicity. These compounds recovered learning and memory function in acute AD model mice with improved pharmacokinetic properties.

There is growing evidence that the small weak scale may be related to self-organized criticality. In this regard, we note that if the strange quark were lighter, the QCD phase transition could have been first order, possibly exhibiting quantum critical points at zero temperature as a function of the Higgs vacuum expectation value v_{h} smaller than (but near) the weak scale. We show that these quantum critical points allow a dynamical selection of the observed weak scale, via quantum-dominated stochastic evolutions of the value of v_{h} during eternal inflation. Although the values of v_{h} in different Hubble patches are described by a probability distribution in the multiverse, inflationary quantum dynamics ensures that the peak of the distribution evolves toward critical points (self-organized criticality), driven mainly by the largest Hubble expansion rate there—the Hubble selection of the universe. To this end, we first explore the quantum critical points of the three-flavor QCD linear sigma model, parametrized by v_{h} at zero temperature, and we present a relaxion model for the weak scale. Among the patches that have reached reheating, it results in a sharp probability distribution of v_{h} near the observed weak scale, which is critical not to the crossover at v_{h}=0 but to the sharp transition at ∼Λ_{QCD}.

Abstract Background Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. The only drug currently approved for clinical use in the treatment of advanced HCC is sorafenib. However, many patients with HCC show reduced sensitivity to sorafenib during treatment. SIRT3, a member of the mammalian sirtuin family, is a tumor suppressor in certain tumor types. However, only few studies have investigated the effects of SIRT3 on tumor prognosis and sorafenib sensitivity in patients with HCC. Here, we aimed to investigate the correlation between SIRT3 expression and glucose metabolism and proliferation in HCC and discover effective compounds that increase endogenous SIRT3 modulation effect of sorafenib. Methods To determine the correlation between SIRT3 and glucose related proteins, immunostaining was performed with liver cancer tissue using various antibodies. To investigate whether the expression of SIRT3 in HCC is related to the resistance to sorafenib, we treated sorafenib after the modulation of SIRT3 levels in HCC cell lines (overexpression in Huh7, knockdown in HepG2). We also employed PD0332991 to modulate the SIRT3 expression in HCC cell and conducted functional assays. Results SIRT3 expression was downregulated in high glycolytic and proliferative HCC cells of human patients, xenograft model and HCC cell lines. Moreover, SIRT3 expression was downregulated after sorafenib treatment, resulting in reduced drug sensitivity in HCC cell lines. To enhance the anti-tumor effect of sorafenib, we employed PD0332991 (CDK4/6-Rb inhibitor) based on the correlation between SIRT3 and phosphorylated retinoblastoma protein in HCC. Notably, combined treatment with sorafenib and PD0332991 showed an enhancement of the anti-tumor effect in HCC cells. Conclusions Our data suggest that the modulation of SIRT3 by CDK4/6 inhibition might be useful for HCC therapy together with sorafenib, which, unfortunately, has limited efficacy and whose use is often associated with drug resistance.

Understanding the spin dynamics in antiferromagnetic (AFM) thin films is fundamental for designing novel devices based on AFM magnon transport. Here, we study the magnon dynamics in thin films of AFM S=5/2 α-Fe_{2}O_{3} by combining resonant inelastic x-ray scattering, Anderson impurity model plus dynamical mean-field theory, and Heisenberg spin model. Below 100 meV, we observe the thickness-independent (down to 15 nm) acoustic single-magnon mode. At higher energies (100–500 meV), an unexpected sequence of equally spaced, optical modes is resolved and ascribed to ΔS_{z}=1, 2, 3, 4, and 5 magnetic excitations corresponding to multiple, noninteracting magnons. Our study unveils the energy, character, and momentum dependence of single and multimagnons in α-Fe_{2}O_{3} thin films, with impact on AFM magnon transport and its related phenomena. From a broader perspective, we generalize the use of L-edge resonant inelastic x-ray scattering as a multispin-excitation probe up to ΔS_{z}=2S. Our analysis identifies the spin-orbital mixing in the valence shell as the key element for accessing excitations beyond ΔS_{z}=1, and up to, e.g., ΔS_{z}=5. At the same time, we elucidate the novel origin of the spin excitations beyond the ΔS_{z}=2, emphasizing the key role played by the crystal lattice as a reservoir of angular momentum that complements the quanta carried by the absorbed and emitted photons.

Three-dimensional (3D) printing technology, with additive manufacturing, can aid in the production of various kinds of patient-specific medical devices and implants in medical fields, which cannot be covered by mass production systems for producing conventional devices/implants. The simulator-based medical image demonstrates the anatomical structure of the disease, which can be used for education, diagnosis, preparation of treatment plan and preoperative surgical guide, etc. The surgical guide is used as a patient-specific medical device for guiding incision, resection, insertion, and marking. As 3D printers can output materials that can be inserted into the human body, the patient-specific implant device that reflects the patient’s anatomy and surgical plan could be of relevance. In addition, patient-specific aids, including gibs, splints, prostheses, and epitheses, could be used for a better outcome. Finally, bio-printing is also used to cultivate cells to produce functional artificial tissues.

Somatostatin analogs, which are used to treat neuroendocrine tumors, inhibit hormone secretion or promote tumor shrinkage; however, their efficacy varies between patients, possibly because of differential expression of somatostatin receptors (SSTRs) in tumors. In this study, we evaluated the regulatory mechanism underlying the expression of SSTR2, the main octreotide target. Thirty miRNAs were found to be dysregulated in neuroendocrine cells (INS-1 cells) incubated with octreotide compared to that in placebo-treated cells. Among the upregulated miRNAs, miR-16-5p was elevated after short-term octreotide treatment. We conducted in vitro experiments to determine whether the expression of miR-16-5p was associated with the regulation of SSTR2 expression and affected octreotide sensitivity in INS-1 cells. Overexpression of miR-16-5p by transfected mimics induced upregulation of SSTR2 expression. Additionally, the expression of miR-16-5p further enhanced octreotide-induced reduction in cell proliferation in both two- and three-dimensional culture of INS-1 cells. Thus, our results reveal the mechanism underlying SSTR2 expression regulation and may aid in developing therapeutic approaches for enhancing the response to octreotide, particularly in patients unresponsive to SSTR2-targeted somatostatin analog treatment.

One major energy loss in electronics is heat dissipation due to induced polarization in dielectric materials in the presence of electric fields. Kim et al. utilize large polarization in liquids to harvest dielectric loss via an energy-loss return gate design, which converts energy back to electricity.

Category: Ankle, Arthroscopy, Sports Introduction/Purpose: The modified Broström operation (MBO) for chronic ankle instability (CAI) has demonstrated good clinical results. Absence of ligamentous tissue was known as a risk factor for recurrence of ankle instability after the sugery. The aim of this study was to evaluate the effect of quality of ligament tissue (anterior talofibular ligament, ATFL) on prognosis in a cohort of patients with CAI after the MBO. Methods: This study was a retrospective case series. A total of 60 patients underwent the MBO for CAI with a mean follow-up of 30.1 months (range, 24-47 months). Presence of ATFL remnant was assessed on ultrasound (US), magnetic resonance imaging (MRI), and arthroscopy in all patients. The foot and ankle outcome score (FAOS) was used to evaluate functional outcomes. Clinical outcomes were compared according to the condition of the ligament remnant. Association with other risk factors was evaluated using multiple linear regression analysis. Results: ATFL was visible in 51/60 cases on US. Thirty patients had thin or absent ATFL on MRI; 22 patients, normal thickness ATFL; and 8 patients, thick ATFL. ATFL was visible in 15 patients on arthroscopy and nonvisible or not clear in 45 cases. Significant differences in FAOS were not noted according to the presence of ATFL remnant on US, arthroscopy, and the grade of ATFL thickness on MRI. No correlation was found between FAOS and the thickness of ATFL. Conclusion: The results suggest that the MBO for patients with CAI had good results, regardless of the presence or absence of ATFL remnant.

BACKGROUND:Recently, porous acupuncture (PA), which is anodized to increase its surface area for higher stimulation intensity, was developed and showed significantly improved therapeutic effects with more comfort as compared with original acupuncture (OA) in vivo. However, the impact of PA on the change of local blood flow as well as its efficacy and acceptability has not yet been confirmed in a clinical trial. In a randomized, controlled crossover clinical trial, we investigated the effects of PA on the change in local blood flow using laser Doppler perfusion imaging and considered the sensation of pain intensity and discomfort severity using a visual analogue scale (VAS) to explore its physiological impact and the possibility of PA in clinical use. METHODS:Twenty-one healthy participants were randomly treated with PA or OA on one side of Zusanli (ST36) and each participant served as his or her own control. Baseline local blood flow and galvanic skin response (GSR) were obtained for 5 min and acupuncture interventions were subsequently performed. Next, local blood flow and GSR were subsequently obtained for 10 min after insertion, 10 min after manipulation, and 5 min after the withdrawal of acupuncture. At the end of the experiment, participants were asked to indicate the sensation of pain intensity at each session of insertion, retention, manipulation, and withdrawal as well as the overall pain intensity and discomfort severity. RESULTS:PA significantly increased the local blood flow as compared with OA and there was no significant difference in GSR between patients treated with PA versus OA in each phase of insertion and manipulation. No significant difference in pain intensity or discomfort severity was found during manipulation, retention, or withdrawal of acupuncture. CONCLUSIONS:These results indicate that PA increases local blood flow, which can be closely related to the observed enhanced performance, without any associated discomfort or pain, suggesting its applicability in clinical practice.

The primordial black hole (PBH) comprising full dark matter (DM) abundance is currently allowed if its mass lies at 10^{−16}M_{⊙}≲M≲10^{−11}M_{⊙}. This lightest mass range is hard to be probed by ongoing gravitational lensing observations. In this paper, we advocate that an old idea of the lensing parallax of gamma-ray bursts (GRBs), observed simultaneously by spatially separated detectors, can probe the unconstrained mass range, and that of nearby stars can probe a heavier mass range. In addition to various good properties of GRBs, astrophysical separations achievable around us—r_{⊕}− AU—are just large enough to resolve the GRB lensing by the lightest PBH DM.

Cache side channel attacks extract secret information by monitoring the cache behavior of a victim. Normally, this attack targets an L3 cache, which is shared between a spy and a victim. Hence, a spy can obtain secret information without alerting the victim. To resist this attack, many detection techniques have been proposed. However, these approaches have limitations as they do not operate in real time. This article proposes a real-time detection method against cache side channel attacks. The proposed technique performs the detection of cache side channel attacks immediately after observing a variation of the CPU counters. For this, Intel PCM (Performance Counter Monitor) and machine learning algorithms are used to measure the value of the CPU counters. Throughout the experiment, several PCM counters recorded changes during the attack. From these observations, a detecting program was implemented by using these counters. The experimental results show that the proposed detection technique displays good performance for real-time detection in various environments.

BackgroundThe aim of this study was to investigate whether adjusting diabetic treatment regimens according to the information obtained from a continuous glucose monitoring system (CGMS) might lead to improved glycemic control in patients with type 2 diabetes.MethodsWe reviewed the medical charts of 172 patients who used the CGMS for 1 year starting in December 2008 and the records of 1,500 patients who visited their regular outpatient clinics during December 2008. Of these patients, a total of 65 CGMS patients and 301 regular outpatients (control group) were enrolled in the study after propensity score matching. There were no differences in baseline glycated hemoglobin (HbA1c), age, and duration of diabetes between the CGMS and the control groups after propensity score matching. The changes in the HbA1c levels from baseline to 6 months were calculated.ResultsThe CGMS group showed a significant improvement in the HbA1c level compared to the control group at 3 months (7.9%±1.6% vs. 7.4%±1.2%, P=0.001) and at 6 months (7.4%±1.2% vs. 7.9%±1.6%, P=0.010). There were significant differences in the treatment modality changes between the CGMS group and the control group.ConclusionUsing a 3-day CGMS was advantageous for improving glucose control in patients with type 2 diabetes and may help these patients to optimize glycemic control in clinical practice.