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Resistance band training (RBT) with functional electrical stimulation (FES) may be an effective exercise regimen for improving age-related motor impairments. This preliminary study investigated the potential effects of bimanual RBT with FES on upper limb motor functions in older adults. This study randomly assigned 22 elderly people to the bimanual RBT with FES (Bi-RBT+FES) group and the RBT without FES (Bi-RBT) group. All participants performed isometric hand-grip force control tasks in unimanual (dominant and non-dominant) and bimanual conditions before and after four weeks of exercise for each group. We quantified the mean force, force accuracy, force variability, and force regularity at two targeted force levels (i.e., 10 % and 40 % of maximum voluntary contraction; MVC) to estimate changes in force control capabilities. The results revealed that the Bi-RBT+FES group demonstrated a greater force accuracy in the dominant hand at 10 % of MVC after training. Non-dominant hands in the Bi-RBT+FES group increased force accuracy at 40 % of MVC and reduced force variability collapsed across two targeted force levels. Both groups showed a decrease in force regularity after training. These preliminary results indicate that Bi-RBT+FES may be a viable option to facilitate functional recovery of the upper limbs in older adults.

Abstract Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation used for improving cognitive functions via delivering weak electrical stimulation with a certain frequency. This systematic review and meta-analysis investigated the effects of tACS protocols on cognitive functions in healthy young adults. We identified 56 qualified studies that compared cognitive functions between tACS and sham control groups, as indicated by cognitive performances and cognition-related reaction time. Moderator variable analyses specified effect size according to (a) timing of tACS, (b) frequency band of simulation, (c) targeted brain region, and (b) cognitive domain, respectively. Random-effects model meta-analysis revealed small positive effects of tACS protocols on cognitive performances. The moderator variable analyses found significant effects for online-tACS with theta frequency band, online-tACS with gamma frequency band, and offline-tACS with theta frequency band. Moreover, cognitive performances were improved in online- and offline-tACS with theta frequency band on either prefrontal and posterior parietal cortical regions, and further both online- and offline-tACS with theta frequency band enhanced executive function. Online-tACS with gamma frequency band on posterior parietal cortex was effective for improving cognitive performances, and the cognitive improvements appeared in executive function and perceptual-motor function. These findings suggested that tACS protocols with specific timing and frequency band may effectively improve cognitive performances.

Abstract This study investigated the effects of altered visual gain levels on bilateral motor synergies determined by the uncontrolled manifold (UCM) hypothesis and force control. Twelve healthy participants performed bimanual index finger abduction force control tasks at 20% of their maximal voluntary contraction across four different visual gain conditions: 8, 80, 256, and 512 pixels/N. Quantifying force accuracy and variability within a trial provided a bimanual force control outcome. The UCM analysis measured bilateral motor synergies, a proportion of good variance to bad variance across multiple trials. Correlation analyses determined whether changes in the UCM variables were related to changes in force control variables from the lowest to highest visual gain conditions, respectively. Multiple analyses indicated that the three highest visual gain conditions in comparison to the lowest visual gain increased values of bilateral motor synergies and target force accuracy. The correlation findings showed that a reduction of bad variance from the lowest to three highest visual gain conditions was related to increased force accuracy. These findings reveal that visual gain greater than 8 pixels/N facilitates bimanual force control.

Transcranial direct current stimulation (tDCS) is one of the non-invasive brain stimulation techniques that can improve motor functions. As bimanual motor actions require high motor cortical activations between hemispheres, applying bilateral anodal stimulation on left and right sides of primary motor cortex (M1) can improve for improvements in bimanual motor tasks. This study investigated which bilateral tDCS protocol effectively improves bimanual hand-grip force control capabilities in healthy young adults. We used three different bilateral tDCS protocols: (a) dual-anodal stimulation on the M1 of bilateral hemispheres (Bi-AA), (b) anodal–cathodal stimulation on the M1 of dominant and nondominant hemispheres (Bi-AC), and (c) sham stimulation (Sham). The results indicated that applying the Bi-AA significantly improved bilateral motor synergies estimated by uncontrolled manifold analysis relative to Sham. However, these differences were not observed in the comparison between Bi-AA and Bi-AC as well as between Bi-AC and Sham. These findings suggest that facilitating motor cortical activations between both hemispheres may be an additional option for advancing interlimb motor coordination patterns.

Per- and polyfluoroalkyl substances (PFAS) are a set of synthetic chemicals which contain several carbon-fluorine (C‒F) bonds and have been in production for the past eight decades. PFAS have been used in several industrial and consumer products including nonstick pans, food packaging, firefighting foams, and carpeting. PFAS require proper investigations worldwide due to their omnipresence in the biotic environment and the resulting pollution to drinking water sources. These harmful chemicals have been associated with adverse health effects such as liver damage, cancer, low fertility, hormone subjugation, and thyroid illness. In addition, these fluorinated compounds show high chemical, thermal, biological, hydrolytic, photochemical, and oxidative stability. Therefore, effective treatment processes are required for the removal and degradation of PFAS from wastewater, drinking water, and groundwater. Previous review papers have provided excellent summaries on PFAS treatment technologies, but the focus has been on the elimination efficiency without providing mechanistic understanding of removal/degradation pathways. The present review summarizes a comprehensive examination of various thermal and non-thermal PFAS destruction technologies. It includes sonochemical/ultrasound degradation, microwave hydrothermal treatment, subcritical or supercritical treatment, electrical discharge plasma technology, thermal destruction methods/incinerations, low/high-temperature thermal desorption process, vapor energy generator (VEG) technology and mechanochemical destruction. The background, degradation mechanisms/pathways, and advances of each remediation process are discussed in detail in this review.

Abstract The need for understanding the low-frequency noise (LFN) of metal oxide semiconductor thin-film transistors (TFTs) is increasing owing to the substantial effects of LFN in various circuit applications. A focal point of inquiry pertains to the examination of LFN amidst bias stress conditions, known to compromise TFT reliability. In this study, we investigate the effects of hot carrier stress (HCS) on zinc tin oxide (ZTO) TFTs by low-frequency noise (LFN) analysis. Asymmetric damage caused by HCS is analyzed by measuring the power spectral density at the source and drain sides. The excess noise generated by the HCS is analyzed with consideration of trap density of states (DOS). It is revealed that the needle defects are generated during the HCS, significantly affecting the LFN characteristics of the ZTO TFTs. Additionally, we observe a self-recovery behavior in the devices and demonstrate the relevant changes in the LFN characteristics following this phenomenon. This study provides valuable insights into the LFN characteristics of ZTO TFTs under HCS conditions and sheds light on the underlying mechanisms.

Abstract Low-frequency noise (LFN) characteristics of semiconductor devices pose a significant importance for understanding their working principle, particularly concerning material imperfections. Accordingly, substantial research endeavors have focused on characterizing the LFN of devices. However, the LFN characteristics of the ambipolar transistors have been rarely demonstrated. Herein, we investigate the effects of ambipolar carrier transport and CYTOP-induced p-type doping on low-frequency noise characteristics of MoTe2 transistors. The source of the 1/f noise differs between the n-type (electron transport) and p-type (hole transport) modes. Notably, the influence of contact resistance is more pronounced in the n-type mode. CYTOP doping suppresses the n-type mode by introducing hole doping effects. Furthermore, CYTOP doping mitigates the impact of contact resistance on excess noise.

Mouse syngeneic tumor models are widely used tools to demonstrate activity of novel anti-cancer immunotherapies. Despite their widespread use, a comprehensive view of their tumor-immune compositions and their relevance to human tumors has only begun to emerge. We propose each model possesses a unique tumor-immune infiltrate profile that can be probed with immunotherapies to inform on anti-tumor mechanisms and treatment strategies in human tumors with similar profiles. In support of this endeavor, we characterized the tumor microenvironment of four commonly used models and demonstrate they encompass a range of immunogenicities, from highly immune infiltrated RENCA tumors to poorly infiltrated B16F10 tumors. Tumor cell lines for each model exhibit different intrinsic factors in vitro that likely influence immune infiltration upon subcutaneous implantation. Similarly, solid tumors in vivo for each model are unique, each enriched in distinct features ranging from pathogen response elements to antigen presentation machinery. As RENCA tumors progress in size, all major T cell populations diminish while myeloid-derived suppressor cells become more enriched, possibly driving immune suppression and tumor progression. In CT26 tumors, CD8 T cells paradoxically increase in density yet are restrained as tumor volume increases. Finally, immunotherapy treatment across these different tumor-immune landscapes segregate into responders and non-responders based on features partially dependent on pre-existing immune infiltrates. Overall, these studies provide an important resource to enhance our translation of syngeneic models to human tumors. Future mechanistic studies paired with this resource will help identify responsive patient populations and improve strategies where immunotherapies are predicted to be ineffective.

Background: Emerging research has suggested a link between ambient temperature and mental and neurological conditions such as depression and dementia. This systematic review aims to summarize the epidemiological evidence on the effects of ambient temperature on mental and neurological conditions in older adults, who may be more vulnerable to temperature-related health effects compared to younger individuals. Methods: A systematic search was conducted in PubMed, Ovid/Embase, Web of Science, and Ovid/PsycINFO on July 17, 2023, and updated on July 31, 2024. We included epidemiological studies investigating the association between ambient temperature exposures and numerous mental and neurological conditions in populations aged 60 years and older. Exclusions were made for studies on indoor or controlled exposure, suicide, substance abuse, those not published as peer-reviewed journal articles, or those not written in English. The risk of bias of included studies was assessed using a tool developed by the World Health Organization (WHO). Qualitative synthesis was performed on all eligible studies, and random-effects meta-analyses were conducted on groups of at least four studies sharing similar study design, exposure metric, and health outcome. The certainty of evidence was assessed using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) framework modified by the WHO. Results: From 16,786 screened articles, 76 studies were deemed eligible, primarily from mainland China and North America. There was notable heterogeneity in study variables and methodologies. The most commonly used exposure metrics were daily absolute temperature and heat waves, and time-series and case-crossover analyses were the most frequently employed study designs. Meta-analysis of four studies on the effect of a 1 °C increase in temperature on hospital admissions/visits for mental disorders showed a pooled risk ratio (RR) of 1.014 (95 % Confidence Interval, CI: 1.001, 1.026). Comparing heat wave days to non-heat wave days, pooled effect estimates showed increased risk in hospital admissions/visits (RR: 1.269; 95 % CI: 1.030, 1.564; six studies) and mortality related to mental disorders (RR: 1.266; 95 % CI: 0.956, 1.678; four studies). Despite the limited number of studies on cold exposures, they consistently reported that lower temperatures were associated with an increased risk of various mental and neurological conditions. Conclusions: This review presents epidemiological evidence of the adverse impacts of ambient temperature exposures, such as high temperatures and heat waves, on mental and neurological conditions among the older adult population, with overall moderate certainty. The findings highlight the need for greater attention to the mental and neurological health of older adults in the context of climate change and population aging.Registration number (PROSPERO ID): CRD42023428137.

This paper conducts a comprehensive cost-benefit analysis of nuclear energy’s contribution to climate change mitigation, with a focus on its potential to reduce the social cost of carbon (SCC). For 31 countries, we employ a four-step methodology to estimate SCC, comparing it against the lifetime costs associated with nuclear power generation. The Upstate New York case study in 2019 reveals that its three nuclear power plants could save approximately $675 million of the social cost of carbon (SCC) annually. Our SCC analyses suggest that the currently operating nuclear power plants worldwide can save the SCC, corresponding to 2.6% of the United States’ annual GDP. According to our cost-benefit analysis, among several countries that operate nuclear reactors, the US and China exhibit high environmental benefits from nuclear power, whereas other countries earn net environmental losses from it. Our study’s robust data analysis methods ensure the reliability and validity of our conclusions, enhancing the relevance of our findings for informing policy decisions. Despite variations in net benefits influenced by societal SCCs and levelized costs of energy (LCOE), nuclear energy emerges as a crucial component in transitioning to a zero-carbon grid. Our study advocates for the use of SCC analysis to incentivize the adoption of low-carbon energy sources.

Background/Objectives: Raloxifene (RLF) is a therapeutic option for invasive breast cancer because it blocks estrogen receptors selectively. Low solubility, limited targeting, first-pass action, and poor absorption are some of the challenges that make RLF in oral form less effective. This study aimed to create an intra-tumoral in situ pH-responsive formulation of RLF–invasome (IPHRLI) for breast cancer treatment, with the goals of sustaining RLF release, minimizing adverse effects, and enhancing solubility, bioavailability, targeting, and effectiveness. Methods: Numerous RLF–invasome formulations were optimized using design expert software (version 12.0.6.0, StatEase Inc., Minneapolis, MN, USA). Integrating an optimal formulation with an amalgam of chitosan and glyceryl monooleate resulted in the IPHRLI formulation. In vivo testing of the IPHRLI formulation was conducted utilizing the Ehrlich cancer model. Results: Requirements for an optimum RLF–invasome formulation were met by a mixture of phospholipids (2.46%), ethanol (2.84%), and cineole (0.5%). The IPHRLI formulation substantially sustained its release by 75.41% after 8 h relative to free RLF. The bioavailability of intra-tumoral IPHRLI was substantially raised by 4.07-fold compared to oral free RLF. Histopathological and tumor volume analyses of intra-tumoral IPHRLI confirmed its efficacy and targeting effect. Conclusions: the intra-tumoral administration of the IPHRLI formulation may provide a potential strategy for breast cancer management.

Education-job match is known to affect employee job satisfaction, as well as their intention to leave the role. Job satisfaction is a critical part of an employee's motivation to remain loyal to and employed within a company. However, ICT sector faces significant skill gaps, driven by college education lagging behind ICT employers' expectations of job skills and experience needed in practice. This article hypothesizes that perceived effectiveness of ICT education in learning job skills ("education-job transferability") in ICT industries can enhance employee job satisfaction and reduce employee turnover. Using a unique dataset extracted from the Labor Force Survey of ICT Workers in South Korea, this article empirically examines the status quo of education-job transferability in ICT industries and its impact on job satisfaction. This article reveals that ICT education is perceived as less effective for learning job skills than other disciplines' education. Moreover, a significant stake of ICT graduates plan to do vocational training, suggesting that higher education is not enough to secure ICT-specialized jobs. Consistent with our hypotheses, we found that an education-job transferability enhances employees' job satisfaction and reduces their intention to leave their current jobs. This article suggests that education-job transferability in Information, Communication and Technology (ICT) industries has a long-lasting effect on both employees and employers, by enhancing employee job satisfaction and potentially mitigating employee turnover.

The transcription factor Myc plays a central role in regulating cell-fate decisions, including proliferation, growth, and apoptosis. To maintain a normal cell physiology, it is critical that the control of Myc dynamics is precisely orchestrated. Recent studies suggest that such control of Myc can be achieved at the post-translational level via protein stability modulation. Myc is regulated by two Ras effector pathways: the extracellular signal-regulated kinase (Erk) and phosphatidylinositol 3-kinase (PI3K) pathways. To gain quantitative insight into Myc dynamics, we have developed a mathematical model to analyze post-translational regulation of Myc via sequential phosphorylation by Erk and PI3K. Our results suggest that Myc integrates Erk and PI3K signals to result in various cellular responses by differential stability control of Myc protein isoforms. Such signal integration confers a flexible dynamic range for the system output, governed by stability change. In addition, signal integration may require saturation of the input signals, leading to sensitive signal integration to the temporal features of the input signals, insensitive response to their amplitudes, and resistance to input fluctuations. We further propose that these characteristics of the protein stability control module in Myc may be commonly utilized in various cell types and classes of proteins.

As the number of overseas projects increase, capabilities of managers should be comprehended by handling risks. Therefore, comparison of project managers’ risk perception and risk handling costs from actual cases is necessary to set the management direction. Thus, eleven risk factors that occur frequently in overseas construction were classified into three categories . Perception of 54 international construction managers were collected by survey and ranked by using relative importance index. Consequently, managers perceived that the impact of risks occurring due to the wrong plan was high and conflict risk was low. Then, the data from 20 cases were amplified by applying Monte-Carlo simulation with statistical verification of reliability and normality . Through multivariable regression analysis, the cost impact of the legal conflict risks with the local subcontractors and engineers was the highest,intensely differed with managers’ perception. Specifically, the risks involving various stakeholders with sufficient time to resolve were not recognized, despite the high-cost impact. Though, fully understanding perception of the host-clients or site labors was difficult, this study is vital in that the conceptual gap was narrowed by numerically comparing the difference between risk perception of managers and actual risk cost. , It would be used as a guideline by focusing on factors with high impact for educating managers at overseas sites.

The Korea Retrospective Dosimetry network (KREDOS) performed an inter-laboratory comparison to confirm the harmonization and reliability of the results of retrospective dosimetry using mobile phone. The mobile phones were exposed to 192Ir while attached to the human phantoms in the field experiment, and the exposure doses read by each laboratory were compared. This paper describes the reference dosimetry performed to present the reference values for inter-comparison and to obtain additional information about the dose distribution. Reference dosimetry included both measurement using LiF:Mg,Cu,Si and calculation via MCNP simulation to allow a comparison of doses obtained with the two different methodologies. When irradiating the phones, LiF elements were attached to the phones and phantoms and irradiated at the same time. The comparison results for the front of the phantoms were in good agreement, with an average relative difference of about 10%, while an average of about 16% relative difference occurred for the back and side of the phantom. The differences were attributed to the different characteristics of the physical and simulated phantoms, such as anatomical structure and constituent materials. Nevertheless, there was about 4% of under-estimation compared to measurements in the overall linear fitting, indicating the calculations were well matched to the measurements.

Abstract Objective We investigated the longitudinal pattern, determining factors, and clinical implications of brain volume changes in N‐methyl d‐aspartate receptor‐antibody (NMDAR) encephalitis. Methods Baseline clinical profiles, treatment profiles, and outcome measured using the Clinical Assessment Scale in Autoimmune Encephalitis (CASE) and modified Rankin scale (mRS) were obtained from a long‐term clinical database documenting an NMDAR encephalitis cohort. In serial MRI, the change in the normalized volume of different brain regions from the baseline evaluation was measured. At each MRI evaluation time point, the cumulative disease burden (CASE score × months) and the cumulative duration of status epilepticus were also evaluated. Results Thirty‐six patients were followed‐up for 28.5 months (range 12–63 months). The volume ratio at last MRI to baseline was the lowest in the cerebellum (94.4 ± 5.7%, p