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Molecularly imprinted polymers (MIPs) as materials with determined levels of selectivity and specificity for designated analytes have recently gained much attention in various application fields. However, with the growing adoption of green analytical chemistry (GAC) principles, it is essential to investigate the greenness of MIP synthesis and its subsequent application in sample preparation, as well as to evaluate the "green"nature of the developed analytical methodologies, such as dispersive solid-phase microextraction (DSPME). Accordingly, the main objective of this research was to evaluate the greenness of MIP-based glycidyl methacrylate synthesis and MIP use as a DSPME sorbent prior to high-performance liquid chromatography with mass spectrometry (HPLC-MS). The green perspective of MIP-DSPME prior to HPLC-MS was investigated using various analytical metric tools such as the Analytical Eco-Scale, the Green Analytical Procedure Index, and Analytical GREEnness (AGREE). Since these analytical tools are not fully implementable for the assessment of the greenness of the MIP synthesis, some alternative approaches were used to optimize the synthesis parameters to make the MIP DSPME sorbent as close as possible to the GAC principles. The calculated AGREE score (0.62) and 91 points in the Analytical Eco-Scale for the proposed DSPME technique using MIP indicated a high level of greenness.

Aniline, the main representative of aromatic amines, occurs in a large number of industries, such as the production of textiles, plastics, medicines, pesticides, rubber, and varnishes.1 Due to practicality and efficiency, a molecularly imprinted polymers (MIPs) can be used as sorbents for removing aniline.2 In this study, magnetic molecularly imprinted polymer was synthesized via suspension copolymerization while characterization was performed by various methods in order to obtain an efficient sorbent for the aniline removal from an aqueous solution. Fourier transform infrared spectroscopy (FT-IR) confirmed characteristic vibrational bands which suggested successful synthesis of MIP, nitrogen gas adsorption-desorption measurements as well as mercury porosimetry have shown that the most dominant pores were mesopores, while scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) confirmed a 3D spherical porous structure with all the expected elements.

In the present study, synthesized macroporous copolymer was used for the sorption of lindane from an aqueous solution. This organochlorine pesticide is classified, according to US EPA, as mutagenic and teratogenic. Residues of lindane can persist in the environment, migrate long distances, and cause widespread contamination. In this way, lindane residues can reach the human body through the food chain. The usage of this pesticide is banned in most countries. However, lindane remains a serious toxicological problem at industrial sites where lindane was used coupled with improper wastewater disposal and has led to serious contamination. In addition, some countries still allow the production and use of lindane, and despite localized restrictions, lindane contamination remains a global problem. Taking into account these reasons, its removal from the environment is of a great significance. Macroporous copolymer was syntesized via suspension copolymerization and characterized by Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). The parameters which affect sorption efficiency of the lindane were: pH, sorption time (tsorp), ion strength (ion), rpm, and dose of sorbent. These variables were optimized by the experimental design which include Plackett- Burman Design (PBD) and Central Composite Design (CCD). After screening step by the PBD, the optimum conditions were obtained by the CCD where the values were investigated in two levels. The design of experiment showed that the ion strength and dose of sorbent were the most significant parameters, while the other variables do not have such an effect on sorption efficiency. Accordingly, the optimum conditions to reach the maximum recovery were: pH 8, 180 min sorption time, 300 rpm, 2 w/v % ion strength and 8 g/L dose of sorbent. The results showed that the studied copolymer could be an efficient sorbent for trace lindane in water with recoveries above 80 %.

Deep eutectic solvents (DESs) have been recognized as promising solvents due to their purity, high conductivity, bio-degradability, thermal stability1. These environmentally friendly solvents are important tools in the creation of green and sustainable technologies. The use of DES in polymer science is highly promising for the development of novel green materials. Therefore, DESs have been used in molecular imprinting in order to improve the properties of molecularly imprinted polymers (MIP). DES are most often prepared by combining two classes of compounds: hydrogen bond donor, HBD (such as amide) and hydrogen bond acceptor, HBA (such as quaternary ammonium salt) in different molar ratios2. By mixing these components in with appropriate molar ratios, eutectic mixtures are formed in a liquid state at temperatures below 100 °C. This study reports the ability of DES-MIP as a sorbent for the removal of aromatic amine from plastic packaging. In order to obtain the most effective sorbent, DESs are prepared by combining choline chloride as HBA with different HBDs, such as urea, glycerol, and ethylene glycol. The results showed that choline chloride:urea was the most suitable DES as modifier of MIP.

The contamination of water with chromium is a global issue that is especially severe in developing countries with intensive mining and heavy industry (South Africa, Pakistan, and India) [1,2]. Trivalent Cr(III) and hexavalent Cr(VI) are the most common forms found in effluent water. Whereas trivalent chromium is a micronutrient (25–35 g/day) involved in the metabolism of lipids and carbohydrates [3,4], hexavalent chromium is exceedingly toxic, teratogenic, and mutagenic. Particularly concerning are its high solubility in water, mobility in detritus, and potential for bioaccumulation in living tissues. Due to these factors, hexavalent chromium has been the subject of numerous studies, especially its removal from effluent [5,6]. These studies have demonstrated that sorption is a highly effective and relatively simple technique for chromium removal from wastewater. In terms of this, magnetic heavy metals nanosorbents derived from inorganic compounds and polymers [7-9] are incredibly intriguing, because they could have been readily extracted from the mixture using an external magnetic field. The sorption investigation of hexavalent chromium in aqueous solutions on the magnetic aminofunctionalized polymer nanocomposite based on glycidyl methacrylate, m-PGMA revealed its highly selectivity and efficiency. [10,11]. The binding mechanism of hexavalent chromium ions onto m-PGMA was investigated using kinetic, equilibrium, and thermodynamic experiments as well as molecular modeling techniques (theoretical quantum-chemical calculations) [12-15]. It was observed that the process occurs in two phases. In the first phase, electrostatic interactions attract hexavalent chromium ions to the surface of the sorbent via the active sites (amino and APTMS groups). Cr(VI) is then converted to Cr(III) ions, which can coordinate with amino or hydroxyl groups on the surface of the sorbent [16]. The trivalent chromium ions that persist in the solution or on the surface of the sorbent are less

A novel porous gold polymer composite was prepared by the functionalization of a glycidyl methacrylate-based copolymer (pGME) with ethylene diamine (pGME-en), and activation by gold (pGME-en/Au), in a simple batch adsorption procedure in an acid solution, at room temperature. Detailed characterization of the pGME-en before and after activation was performed. The main focuses of this research were the design of a method that can enable the recovery of gold and the reuse of this multipurpose sorbent as an antimicrobial agent. Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) analysis pointed out amine groups as the primary binding sites for Au activation, while hydroxyl groups also contributed to the chelation reaction. pGME-en exhibited fast gold adsorption with an adsorption half-time of 5 min and an equilibrium time of 30 min. The maximal adsorption capacity was about 187 mg/g. The analysis of sorption experimental data with a non-linear surface reaction and diffusion-based kinetic models revealed the pseudo-second-order and Avrami model as the best fit, with unambiguous control by liquid film and intra-particle diffusion. The biological activity studies against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, and Candida albicans revealed moderate activity of pGME-en/Au against different bacterial and fungal species. pGME-en/Au was stable in a saline solution, with a release of approximately 2.3 mg/g after 24 h.

The contamination of water with chromium is a global issue that is especially severe in developing countries with intensive mining and heavy industry (South Africa, Pakistan, and India) [1,2]. Trivalent Cr(III) and hexavalent Cr(VI) are the most common forms found in effluent water. Whereas trivalent chromium is a micronutrient (25–35 g/day) involved in the metabolism of lipids and carbohydrates [3,4], hexavalent chromium is exceedingly toxic, teratogenic, and mutagenic. Particularly concerning are its high solubility in water, mobility in detritus, and potential for bioaccumulation in living tissues. Due to these factors, hexavalent chromium has been the subject of numerous studies, especially its removal from effluent [5,6]. These studies have demonstrated that sorption is a highly effective and relatively simple technique for chromium removal from wastewater. In terms of this, magnetic heavy metals nanosorbents derived from inorganic compounds and polymers [7-9] are incredibly intriguing, because they could have been readily extracted from the mixture using an external magnetic field. The sorption investigation of hexavalent chromium in aqueous solutions on the magnetic aminofunctionalized polymer nanocomposite based on glycidyl methacrylate, m-PGMA revealed its highly selectivity and efficiency. [10,11]. The binding mechanism of hexavalent chromium ions onto m-PGMA was investigated using kinetic, equilibrium, and thermodynamic experiments as well as molecular modeling techniques (theoretical quantum-chemical calculations) [12-15]. It was observed that the process occurs in two phases. In the first phase, electrostatic interactions attract hexavalent chromium ions to the surface of the sorbent via the active sites (amino and APTMS groups). Cr(VI) is then converted to Cr(III) ions, which can coordinate with amino or hydroxyl groups on the surface of the sorbent [16]. The trivalent chromium ions that persist in the solution or on the surface of the sorbent are less

Organohlorni pesticid - lindan, smatra se potencijalno kancerogenim jedinjenjem. Lindan i njegovi ostaci mogu da opstanu u životnoj sredini veoma dugo, migrirajući i potencijalno izazivajući zagađenje životne sredine. Ostaci lindana mogu dospeti i u ljudski organizam kroz lanac ishrane, jer je ovo potencijalno toksično jedinjenje sklono bioakumulaciji. Kontaminacija lindanom je globalni problem, a njegovo uklanjanje iz životne sredine je neophodno. U ovom istraživanju sorpcija lindana iz vodenog rastvora urađena je sa makroporoznim kopolimerom na bazi glicidil metakrilata, koji se pokazao kao veoma efikasan sorbent, sa sorpcijom lindana od oko 0%. Za određivanje koncentracije lindana korišćena je analitička tehnika, gasna hromatografija sa detektorom za hvatanje elektrona GC-ECD. Osim sorpcije, uspešno je urađena i desorpcija lindana., Organochlorine pesticide - lindane, is considered as potentially carcinogenic compound. Lindane and its residues can persist in the environment for a very long period, migrating and potentially causing environmental pollution. Residues of lindane can also enter the human body through the food chain, because this potentially toxic compound is prone to bioaccumulation. Lindane contamination is a global problem, and its removal from the environment is essential. In this research, the sorption of lindane from an aqueous solution was performed with a macroporous copolymer based on glycidyl methacrylate, which proved to be a very effective sorbent, with lindane sorption of about 80%. An analytical technique, gas chromatography with an electron capture detector GC-ECD, was used to determine the concentration of lindane. In addition to sorption, desorption of lindane was also successfully performed.

Polyurethane networks (PUNs) based on hyperbranched polyesters (HBP), polycaprolactone (PCL), and isophorone diisocyanate were prepared.1,2 PUNs consist of different content of hard (HS) and soft segments (SS). The impact of the HBP and the content of the SS on the structure and viscoelastic properties of the prepared PUNs were investigated. XRD analysis confirmed that PUNs with lower SS content were amorphous, while samples with the highest SS content had a certain degree of crystallinity. Viscoelastic properties of PUNs depend on the SS content and used HBP. These PUNs have potential application as coatings.

Macroporous (glycidyl methacrylate) GMA-based composite was synthesized via suspension polymerization in the presence of 2 wt. % magnetic nanoparticles and functionalized with triethylenetetramine. Copper was immobilized on composite by contacting modified copolymer with 0.1 M solution of CuCl2, at pH 5, and 25 ̊C. The obtained composite was characterized by mercury porosimetry, Fourier transform infrared spectroscopy (FTIR) analysis and atomic force microscopy (AFM). GMA-based composites, due to their properties (size, porosity, etc.), and the presence of reactive epoxy group, have found a variety of applications as sorbents, enzyme supports, in biomedical applications, for metal and organic compounds sorption.1 The antimicrobial activity of the synthesized GMA/Cu copolymer against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger as representatives for Gram-positive bacteria, Gram-negative bacteria, yeast and fungi were investigated in this study.2 The copolymer displayed good antimicrobial activity against all analyzed microbes, which makes it a material that can be potentially used for biomedical (antibacterial and antifungal) applications.

Organochlorine pesticide - lindane, according to the US EPA classification, is considered as potentially carcinogenic compound. Although the usage of this pesticide is banned in many countries, it is still used in some. As persistent organic compound, lindane and its residues can persist in the environment for a very long time, migrating over long distances, potentially causing environmental pollution. Lindane residues can reach the human body through the food chain, because this potentially toxic compound is prone to bioaccumulation, and this is serious toxicological problem especially at industrial and agricultural sites where lindane has been used directly, or has reached due to improper wastewater disposal. Despite bans on its use, lindane contamination remains a global problem, and its removal from the environment is of crucial importance. In this research, for the sorption of lindane from an aqueous solution, a macroporous copolymer based on glycidyl methacrylate was utilized, which proved to be a very effective sorbent, with lindane sorption of about 80 %. Analytical technique, Gas Chromatography with an Electron Capture Detector (GC-ECD), was used for determination of lindane concentration. In addition to sorption, desorption of lindane was also successfully performed using different solvents, which confirmed the possibility of recycling and reuse of the investigated polymer., Organohlorni pesticid - lindan, prema US EPA klasifikaciji, smatra se potencijalno kancerogenim jedinjenjem. Iako je upotreba ovog pesticida zabranjena u mnogim zemljama, u nekim se i dalje koristi. Kao perzistentno organsko jedinjenje, lindan i njegovi ostaci mogu da opstanu u životnoj sredini veoma dugo, migrirajući na velike udaljenosti, potencijalno izazivajući zagađenje životne sredine. Ostaci lindana mogu da dospeju u ljudski organizam kroz lanac ishrane, jer je ovo potencijalno toksično jedinjenje sklono bioakumulaciji, a to je ozbiljan toksikološki problem posebno u industrijskim i poljoprivrednim lokacijama gde se lindan direktno koristio ili je dospeo usled nepravilnog odlaganja otpadnih voda. Uprkos zabranama njegove upotrebe, kontaminacija lindanom ostaje globalni problem, a njegovo uklanjanje iz životne sredine je od ključnog značaja. U ovom istraživanju sorpcija lindana iz vodenog rastvora urađena je sa makroporoznim kopolimerom na bazi glicidil metakrilata, koji se pokazao kao veoma efikasan sorbent, sa sorpcijom lindana od oko 0 %. Za određivanje koncentracije lindana korišćena je analitička tehnika, gasna hromatografija sa detektorom za hvatanje elektrona GC-ECD (Gas Chromatography with an Electron Capture Detector). Osim sorpcije, uspešno je urađena i desorpcija lindana korišćenjem različitih rastvarača, što je potvrdilo mogućnost reciklaže i ponovne upotrebe ispitivanog polimera.

Lindane was one of the most commonly used organochlorine pesticides for controlling a wide range of horticultural, agricultural, and public health pests during the second half of the 20th century. [1] Owing to its toxic nature, bioaccumulation capability, and long transportable nature, it belongs to a group of persistent organic pollutants (POPs). [2] Although lindane use has been restricted or even banned, its residues persist and represent a serious environmental problem since lindane residues are still found in water, sediments, soil, plants, and animals. [3] Therefore, there is a growing interest in lindane removal or degradation by various methods. In this context, sorption has received considerable attention as one of the most effective and simplest technological approaches for the removal of lindane. In the present study, we investigated the kinetics of the lindane sorption process onto a porous functionalized copolymer based on glycidyl methacrylate. Five widely used isotherm kinetic models (pseudo-first-order, pseudo-second-order, Elovich, Avrami, and fractional power models) were employed via non-linear and linear fitting. The extent of kinetic model compatibility was evaluated through seven error functions. According to the obtained results, the pseudo-second-order model was the best-fitting kinetic model for describing the kinetics of lindane sorption by the investigated sorbent.

Kinetic, equilibrium and thermodynamic of arsenate sorption onto magnetic polymer sorbent based on glycidyl methacrylate were investigated. The maximum sorption capacity of 0.59 mg/g was obtained. The experimental data were analyzed by seven kinetic models and eight isotherm models. Nonlinear regression method was used to fit the data to the kinetic and isotherm models. Thus, two error functions; coefficient of determination and Chi-square statistic test were applied to evaluate the sorption data. It was shown that arsenate sorption obeys the pseudo-second-order model with evident influence of pore and film diffusion. The Freundlich and all three-parameter isotherm models proved to be the best representatives of arsenate sorption. Thermodynamic studies implied endothermic and spontaneous process in nature.

Magnetic macroporous poly(glycidyl methacrylate-co-trimethylolpropane trimethacrylate) nanocomposite was synthesized by suspension copolymerization. The obtained nanocomposite was characterized by Fourier transform infrared spectroscopy (FT-IR), mercury porosimetry and scanning electron microscopy (SEM). Such magnetic nanocomposite was applied as sorbent for a dispersive solid-phase microextraction (DSPME) for aniline preconcentration from water samples. The parameters affecting the microextraction were optimized. The screening of DSPME parameters was determined using Plackett-Burman design (PBD). For the optimization of the most important factors Central Composite Design (CCD) was used. The analysis of the results showed that the pH value and temperature of desorption were the most significant factors.

Improving the affinity and selectivity of polymeric materials for sorbing ionic species, particularly heavy metals that pose a high environmental risk, is crucial from an environmental standpoint. Research on the mechanism of sorption can aid in selecting the optimal sorbent for a given application. Sorption occurs as a result of various interactions. Sorption includes diffusion of ions through solution (typically the quickest), diffusion of ions through the boundary layer surrounding the sorbent surface, diffusion through the porous structure of the sorbent (intra-particle diffusion), and binding to active sites on sorbent surfaces. Kinetic and equilibrium models explain the sorption mechanism but not the nature of interactions, which is essential for predicting the selectivity and efficiency of the sorbent based on particular ionic species. As a result, we were compelled to approach the molecular level. Active sites on the surface of the magnetic aminofunctionalized polymer, which are amino functional groups, are used to bind ions to the magnetic nanocomposite. The sorption process can be viewed as the sum of ion-ligand unit interactions. Unit complex formation and stability can be studied with statistical analysis and quantum chemical calculations. The Cambridge database (CSD) improves the crystal structure of complex ion-ligand. Based on binding energy, DFT (Density Functional Theory) predicts the stability of complex molecules (unit ion-ligand interactions). To ensure an accurate calculation, it is essential to include all system parameters, including sorbent structure, ligand properties, ligand charge under specific conditions, ion forms and charges, and solvatation effects. In the early stages of research, defining the system's model lets researchers make theoretical predictions about the magnetic aminofunctionalized polymer sorbent's affinity and selectivity for certain ionic species.

In this paper, three molecularly imprinted polymers (MIPs) with different molar ratios of amine (ethylene diamine) and template (aniline) (1:1, 2:1, 4:1) were synthesized by the surface imprinting method. The obtained MIPs were characterized by scanning electron microscopy and FTIR, and investigated as a potential aniline sorbents at different pH. The results showed that MIP (4:1) had good potential for the removal of aniline.

Magnetic macroporous poly(glycidyl methacrylate-co-trimethylolpropane trimethacrylate) nanocomposite was synthesized by suspension copolymerization. The obtained nanocomposite was characterized by Fourier transform infrared spectroscopy (FT-IR), mercury porosimetry and scanning electron microscopy (SEM). Such magnetic nanocomposite was applied as sorbent for a dispersive solid-phase microextraction (DSPME) for aniline preconcentration from water samples. The parameters affecting the microextraction were optimized. The screening of DSPME parameters was determined using Plackett-Burman design (PBD). For the optimization of the most important factors Central Composite Design (CCD) was used. The analysis of the results showed that the pH value and temperature of desorption were the most significant factors.

Kinetic, equilibrium and thermodynamic of arsenate sorption onto magnetic polymer sorbent based on glycidyl methacrylate were investigated. The maximum sorption capacity of 0.59 mg/g was obtained. The experimental data were analyzed by seven kinetic models and eight isotherm models. Nonlinear regression method was used to fit the data to the kinetic and isotherm models. Thus, two error functions; coefficient of determination and Chi-square statistic test were applied to evaluate the sorption data. It was shown that arsenate sorption obeys the pseudo-second-order model with evident influence of pore and film diffusion. The Freundlich and all three-parameter isotherm models proved to be the best representatives of arsenate sorption. Thermodynamic studies implied endothermic and spontaneous process in nature.

In this report, magnetic porous polymer functionalized with pentaethylenehexamine (mP-PEHA) was tested as CO2 sorbent. The sorbent mP-PEHA was characterized by Fourier transform infrared spectroscopy in ATR mode (FTIR-ATR), scanning electron microscopy (SEM) and mercury porosimetry. CO2 adsorption was determined using a pulse gas chromatographic method. At optimal adsorption conditions (20 °C), the CO2 sorption capacity reached 10.8 ml CO2/g (0.48 mmol CO2/g). Temperature-programmed desorption (TPD) experiments were conducted to calculate the activation energy of CO2 desorption. Low activation energy (18.34 kJ/mol) and high desorption rate, with a stable uptake in five adsorption/desorption cycles, suggest mP-PEHA as potentially excellent sorbent for CO2 absorption.

A core-shell amino-functionalized glycidyl methacrylate magnetic molecularly imprinted polymer (MIP) was synthesized by the suspension polymerization/surface imprinting method and characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), mercury porosimetry, nitrogen gas adsorption–desorption, and elemental analysis. This MIP was used as the sorbent in dispersive solid-phase microextraction (DSPME) of aniline from textile wastewater prior to high-performance liquid chromatography-mass spectrometry (HPLC-MS) measurements. Since aniline is toxic and a probable human carcinogen, its determination in water is of great significance. This is a challenging task because aniline is usually present at trace levels. The effects of different DSPME variables on the preconcentration efficiency have been studied by using the Plackett–Burman screening design of experiments (DoE) followed by response surface methodology optimization using the Box-Behnken design. Thus, DoE enabled the investigation of several variables simultaneously. Under optimized conditions, aniline was effectively and selectively separated by a small amount of the DSPME sorbent and detected in real textile wastewater samples. The method detection limit of 1 ng mL−1 was attained, with good method linearity and acceptable recovery and precision. The results showed that the studied MIP could be a reliable DSPME sorbent for efficiently analyzing trace aniline in real wastewater samples.

An amino‐functionalized magnetic macroporous copolymer of glycidyl methacrylate (GM) and ethylene glycol (E) dimethacrylate (m‐poly(GME)‐deta) was synthesized, fully characterized, and used to investigate the adsorption of vanadium (V) oxyanions from aqueous solutions (Ci = 0.5 mM) in a batch system at room temperature (298 K). Pseudo‐first‐order (PFO), pseudo‐second-order (PSO), Elovich, and intra‐particle diffusion (IPD) models were used to analyze the kinetic data. The study showed that sorption is rapid, i.e., the sorption half‐time is approximately one minute. Initially, the sorption process primarily involved surface sorbent particles, and it was best described by the PSO model. However, after saturation of the surface active sites is attained, the sorption rate decreases significantly because of limitations of the diffusion rate, which is then primarily controlled by the IPD process. The sorption process is favorable in the pH range of 3–6 due to the strong electrostatic interactions between the absorption centers of copolymer and vanadium (V) oxyanions. In the stated pH range, deta absorption centers with two and three protonated N atoms are in equilibrium as studied by quantum chemical modeling. Among V(V) species present in diluted aqueous media, the adsorption of H2VO4− ions dominates.

This study is focused on the optimization of the synthesis of nanocomposite by suspension copolymerization in the presence of functionalized magnetic nanoparticles. The effect of parameters such as type and amount of stabilizing agent as well as the stirring rate of the reaction mixture on the shape and particle size obtained nanocomposite are studied. The magnetic nanocomposite with the best morphology properties was characterized using optical microscopy, FTIR, and mercury porosimetry.

Molecularly imprinted polymers (MIPs) are new functional polymers with pre-designed molecular selectivity. Synthesis of MIP is performed using a template added into a polymer matrix. After that, the template is removed, leaving cavities and active binding sites. A template could be a target compound, its fragment or a molecule similar to the target molecule by its size, shape and functional groups (dummy template). In this way, the molecularly imprinted polymers can be bonded to original templates, as well as related template molecules. Due to their robustness, long-term stability, high selectivity, reproducibility, and cost-effectiveness, they are suitable for a wide range of applications such as chemical and biological sensors, solid-phase extraction, selective carriers for various types of chromatography, artificial receptors for drug testing, and human viral pathogens detection. Because of continuous evolution and fast virus mutation, there is a need for technologies that would evolve as fast. So far, MIP has been used for the detection of influenza virus, dengue virus, and human immunodeficiency virus. Detection of different subtypes of influenza virus (H5N1, H5N3, H1N1, H1N3, and H6N1) is obtained using a quartz sensor QCM coated with MIP based on methacrylate and N-vinylpyrrolidone. To detect the dengue virus, a MIP has been developed to recognize the non-structural protein NS1 found in the virus itself. Linear 15-mer peptides derived from NS1 protein of Japanese encephalitis are used as a template (Thr-Glu-Leu-Arg-Tir-Ser-Trp-Lis-Thr-Trp-Gli-LisAla-Lis-Met) based on dengue NS1 virus epitope mapping to antibody D2/8-1. Dopamine is used as a functional monomer for the synthesis of MIP for HIV detection, while a synthetic peptide with 35 amino acid residues similar to the amino acid sequence on the glycoprotein HIV-1 gp41 is used as a template. Based on previous research of similar viruses, this type of polymer is found to have a potential for coronavirus detec, Molekulsko otisnuti polimeri (MIP) predstavljaju nove funkcionalne polimere sa unapred dizajniranom molekulskom selektivnošću. Sinteza MIP-a se vrši korišćenjem šablona koji se dodaje u polimernu matricu, nakon čega se uklanja ostavljajući šupljine i aktivna mesta vezivanja. Šablon može biti ciljno jedinjenje, njegov fragment ili molekul veličine, oblika i funkcionalnih grupa sličnih ciljnom (tzv. lažni šablon). Na taj način molekulsko otisnuti polimeri mogu vezati kako originalne, tako i srodne molekule šablona. Zahvaljujući robusnosti, dugoročnoj stabilnosti, visokoj selektivnosti, obnovljivosti i ekonomičnosti pogodni su za širok spektar primene kao što su hemijski i biološki senzori, ekstrakcija čvrste faze, selektivni nosači za različite vrste hromatografije, veštački receptori za ispitivanje lekova, kao i za detekciju humanih virusnih patogena. Zbog stalne evolucije i brzine mutiranja virusa javlja se potreba za tehnologijama koje će ići u korak sa novonastalim situacijama. U dosadašnjim istraživanjima MIP je korišćen za detekciju virusa gripa, denga virusa, kao i virusa humane imunodeficijencije. Detekcija različitih podtipova virusa gripa (H5N1, H5N3, H1N1, H1N3 i H6N1) ostvarena je pomoću kvarcnog senzora QCM koji je premazan MIP-om na bazi metakrilata i N-vinilpirolidona. Za otkrivanje virusa denge razvijen je MIP za prepoznavanje nestrukturnog proteina NS1 koji se nalazi u samom virusu. Linearni 15-merni peptidi izvedeni iz NS1 proteina Japanskog encefalitisa korišćeni su kao šablon (Thr-Glu-Leu-Arg-Tir-Ser-Trp-Lis-Thr-Trp-Gli-LisAla-Lis-Met) na osnovu mapiranja epitopa virusa denge NS1 prema antitelu D2/8-1. Kao funkcionalni monomer u sintezi MIP-a za detekciju HIV virusa koristi se dopamin, dok se kao šablon koristi sintetički peptid sa 35 aminokiselinska ostatka sličan aminokiselinskoj sekvenci na glikoproteinu HIV-1 gp41. Na osnovu prethodnih saznanja o sličnim virusima, ova vrsta polimera mogla bi da ima potencijalnu primenu za detekciju korona virus

Vanadium and its compounds have multiple applications in industry, such as in alloys to increase strength and as a catalyst. Vanadium(V) is the dominant form in the aquatic environment and also, it is the most hazardous product which can cause an environmental problem due to its high solubility and toxicity. The aim of this study was to investigate the possible use of a novel magnetic polymer/bentonite composite prepared by suspension copolymerization of glycidy. methacrylate (GMA) and ethylene alyco. dimethacrylate (EGDMA) and functionalize with ethylene diamine and hexamethylene diamine (MB-PSME-ED and MB-PGME-HD), for V(V) sorption from aqueous solution. The influence of contact time on V(V) sorption onto MB-PGME-ED and MB-PGME-HD was investigated. All sorption experiments were performed in batch static conditions, at pH 7.6 and room temperature (298 K). Maximum sorption capacities, Qmax, were 2.47 mg/g and 1.94 mg/g for MB-PGME-ED and MB-PGME-HD, respectively. Surface-reaction (pseudo-first order, pseudo-second order and Elovich) and particle diffusion based (intra-particle diffusion, liquid film diffusivity model, Bangham, Boyd and McKay's) kinetic models were used for analysis of V(V) sorption kinetic data. Both sorbents obeyed the pseudo-second order kinetic model, with evident influence of pore diffusion. Desorption experiments of V(V) loaded MB-PGME-ED and MB-PGME HD performed with 0.1 M NaOH and 0.1 M HNO3 showed that NaCH is a better stripping agent for V(V) ion within both samples.

Statistička analiza podataka dobijenih iz kristalnih struktura, ekstrahovanih iz Kembričke baze strukturnih podataka (eng. CSD), pokazala je da atomi S i Se u nepolarnom okruženju pokazuju sličnu tendenciju ka pojedinim tipovima interakcija [1]. Najbrojnije su strukture sa C-H…S i CH…Se interakcijama (~ 80%), dok su Se…Se i S …S interakcije druge po zastupljenosti (~ 5%). Kada se S ili Se nalaze u polarnom okruženju (u neposrednoj blizini imaju O-H ili N-H grupu) raspodela pojedinih tipova interakcija je nešto drugačija. Statistička analiza interakcija S i Se (kriterijumi: d < 4.0Å (za S) d < 4.5Å (za Se), Slika) pokazala je da su najbrojnije interakcije sa H atomom (u oba slučaja oko 47%), dok su interakcije koje uključuju C atome (interakcije sa nepolarnim grupama) druge po zastupljenosti. Interakcije sa nepolarnim C-H grupama su nešto zastupljenije kod Se (30%) nego kod S atoma (21%), dok su interakcije sa polarnim O-H i N-H grupama manje brojne kod Se (ukupno 10%) nego kod S atoma (ukupno 16%). Neočekivano, simultane interakcije X atoma sa S/Se atomom i polarnom O-H/N-H grupom (H…X<3.5 Å) su zastupljene u udelu od samo 20% (Slika). Rezultati doking studije sugerišu da bi PBISe (Se jedinjenje) moglo biti bolji inhibitor iNOS (inducibilne azot-monoksid sintaze) nego njegov S derivat (PBIT). Sve orijentacije PBISe su grupisane na istom mestu (aktivno mesto, Slika) što dovodi do mnogo bolje efikasnosti ovog molekula u odnosu na PBIT, za kojeg su nađena tri mesta vezivanja (Slika). Ovo se slaže sa eksperimentalnim rezultatima koji ukazuju na to da PBISe ubija ćelije melanoma više od 10 puta efikasnije od drugog iNOS inhibitora (PBIT)., Statistical analysis of data from crystal structures, extracted from Cambridge Structural Database(CSD) have shown that S and Se atoms in nonpolar environment display similar tendencytoward specified type interactions [1]. The most numerous are structures with C−H···Se andC−H···S interactions (~80%), while structures with Se···Se and S···S interactions (~5%) are notablyless numerous (second type of interactions). When S or Se atoms is in a polar environment(there is OH or NH grous in the vicinity), the distribution of certain types of interactions is slightlydifferent. Statistical analysis of S and Se interactions (criteria: d < 4.0 Å (for S) d < 4.5 Å (for Se),Figure) showed the most numerous interactions with the H atom (in both cases about 47%), whileinteractions involving C atoms (interactions with non-polar groups) are second in prevalence.Interactions with non-polar C-H groups are slightly more numerous for Se (30%) than for S atom(21%), while interactions with polar O-H and N-H groups are less numerous for Se (10% in total)than in case of S atom (16% in total). Unexpectedly, the simultaneous interactions of X atom withthe S/Se atom and the polar OH/N-H group (H…X<3.5 Å) are only present in an amount of about20%.Results from docking study suggested that PBISe (Se compound) could be beter inhibitor ofiNOS (inducible nitric oxide synthase) than its S derivative (PBIT). All orientations of PBISe areclustered at the same site (active site, Figure) leading to much better efficiency of this moleculecompared to PBIT, where three binding sites can be observed (Figure). This is in strong agreementwith experimental results pointing that PBISe kills melanoma cells >10−fold more effectively thanother iNOS inhibitors (PBIT).

A novel functionalized macroporous poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate), (pSGE-eda-EDTA) copolymer was obtained by two-step functionalization with ethylene diamine (EDA) and ethylenediaminetetraacetic acid (EDTA). The initial copolymers, as well as functionalized samples, were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), mercury porosimetry and elemental analysis. Additionally, the content of amino and carboxyl group, as well as the point of zero charge (pHPZC value), were determined.