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1. Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells

3. Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer

4. The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity

5. Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response

6. Downregulation of Keap1 Confers Features of a Fasted Metabolic State

7. Pirin, an Nrf2-Regulated Protein, Is Overexpressed in Human Colorectal Tumors

9. Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

10. Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

11. Construction of Fused Tropone Systems Through Intramolecular Rh(I)-Catalyzed Carbonylative [2+2+2+1] Cycloadditon of Triynes

13. Data from Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans

14. Supplementary Figure 1 from The Acetylenic Tricyclic Bis(cyano enone), TBE-31 Inhibits Non–Small Cell Lung Cancer Cell Migration through Direct Binding with Actin

15. Supplementary Video 1 from The Acetylenic Tricyclic Bis(cyano enone), TBE-31 Inhibits Non–Small Cell Lung Cancer Cell Migration through Direct Binding with Actin

16. Supplemental Figures S1-9 from Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans

17. Supplementary Video 2 from The Acetylenic Tricyclic Bis(cyano enone), TBE-31 Inhibits Non–Small Cell Lung Cancer Cell Migration through Direct Binding with Actin

18. Data from The Acetylenic Tricyclic Bis(cyano enone), TBE-31 Inhibits Non–Small Cell Lung Cancer Cell Migration through Direct Binding with Actin

19. Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1

20. Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer

21. Inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP binding and hydrolysis via CDDO and its derivatives

22. Recent progress in the strategic incorporation of fluorine into medicinally active compounds

23. List of contributors

24. Curious effects of fluorine on medicinally active compounds

25. Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

26. Design, Synthesis, and Biological Evaluations of Asymmetric Bow-Tie PAMAM Dendrimer-Based Conjugates for Tumor-Targeted Drug Delivery

27. Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for 11C-Labeling

28. Design and synthesis of tumor-targeting theranostic drug conjugates for SPECT and PET imaging studies

29. Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

30. Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression

31. The kinase inhibitor AT9283 selectively kills colorectal cancer cells with hyperactive NRF2

32. List of contributors

33. Case studies of fluorine in drug discovery

34. Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

35. Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme

36. Characterization of denitrification and net N2O-reduction properties of novel aerobically N2O-reducing bacteria

37. Downregulation of Keap1 Confers Features of a Fasted Metabolic State

38. Construction of Fused Tropone Systems Through Intramolecular Rh(I)-Catalyzed Carbonylative [2+2+2+1] Cycloadditon of Triynes

39. Synthesis of Colchicinoids and Allocolchicinoids through Rh(I)-Catalyzed [2+2+2+1] and [2+2+2] Cycloadditions of o-Phenylenetriynes with and without CO

40. Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for

41. Author Correction: Pathogenic p62/ SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

42. Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans

43. Strategic Incorporation of Fluorine for Drug Discovery and Development

44. Synthesis of13C215N2-labeled anti-inflammatory and cytoprotective tricyclicbis(cyanoenone) ([13C215N2]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method

45. An Improved Synthesis of a Hydroxymethyl Tricyclic Ketone from Cyclohexanone, the Key Processes for the Synthesis of a Highly Potent Anti-inflammatory and Cytoprotective Agent

46. Microwave-assisted Diels–Alder reactions between Danishefsky's diene and derivatives of ethyl α-(hydroxymethyl)acrylate. Synthetic approach toward a biotinylated anti-inflammatory monocyclic cyanoenone

47. Highly Potent Activation of Nrf2 by Topical Tricyclic Bis(Cyano Enone): Implications for Protection against UV Radiation during Thiopurine Therapy

48. Synthesis, Chemical Reactivity as Michael Acceptors, and Biological Potency of Monocyclic Cyanoenones, Novel and Highly Potent Anti-inflammatory and Cytoprotective Agents

49. A Novel Acetylenic Tricyclic bis-(Cyano Enone) Potently Induces Phase 2 Cytoprotective Pathways and Blocks Liver Carcinogenesis Induced by Aflatoxin

50. A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice

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