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894 results on '"Tada, Hayato"'

9. Characterization of baseline clinical factors associated with incident worsening kidney function in patients with non-valvular atrial fibrillation: the Hokuriku-Plus AF Registry

Author

Hayashi, Kenshi, Tanaka, Yoshihiro, Tsuda, Toyonobu, Nomura, Akihiro, Fujino, Noboru, Furusho, Hiroshi, Sakai, Norihiko, Iwata, Yasunori, Usui, Soichiro, Sakata, Kenji, Kato, Takeshi, Tada, Hayato, Kusayama, Takashi, Usuda, Keisuke, Kawashiri, Masa-aki, Passman, Rod S., Wada, Takashi, Yamagishi, Masakazu, and Takamura, Masayuki

Published
2023
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10. Clinical Characteristics of Homozygous Familial Hypercholesterolemia in Japan: A Survey Using a National Database

Author

Harada-Shiba, Mariko, Ishibashi, Shun, Yokoyama, Shinji, Shimano, Hitoshi, Yokote, Koutaro, Bujo, Hideaki, Yamashita, Shizuya, Tsukamoto, Kazuhisa, Ikewaki, Katsunori, Gotoda, Takanari, Dobashi, Kazushige, Takegami, Misa, Sekijima, Yoshiki, Ishigaki, Yasushi, Okazaki, Hiroaki, Nohara, Atsushi, Koyama, Shingo, Inagaki, Kyoko, Ono, Koh, Koseki, Masahiro, Daida, Hiroyuki, Takahashi, Manabu, Nakamura, Kimitoshi, Miida, Takashi, Kawashiri, Masa-aki, Minamino, Tetsuo, Okazaki, Sachiko, Tada, Hayato, Wada, Jun, Ogura, Masatsune, Yoshida, Hiroshi, Kataoka, Yu, Ohmura, Hirotoshi, Hori, Mika, Matsuki, Kota, Yamamoto, Masashi, Takeuchi, Yasuo, Nakatsuka, Atsuko, Masuda, Daisaku, Hirayama, Satoshi, Kuroda, Masayuki, Yamaguchi, Takashi, and Takeji, Yasuaki

Published
2023
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11. Negative correlation between organ heteroplasmy, particularly hepatic heteroplasmy, and age at death revealed by post-mortem studies of m.3243A > G cases

Author

Yagi, Kunimasa, Okazaki, Satoko, Ohbatake, Azusa, Nakaya, Masako, Liu, Jianhui, Arite, Eiko, Miyamoto, Yukiko, Ito, Naoko, Nakano, Kaoru, Yamaaki, Naoto, Honoki, Hisae, Fujisaka, Shiho, Chujo, Daisuke, Tsunoda, Shin-ichiro, Yanagimoto, Kunio, Nozue, Tsuyoshi, Yamada, Masayo, Ooe, Kotaro, Araki, Tsutomu, Nakashima, Akikatsu, Azami, Yasushi, Sodemoto, Yukio, Tadokoro, Kenichi, Nagano, Makoto, Noguchi, Tohru, Nohara, Atushi, Origasa, Hideki, Niida, Yo, and Tada, Hayato

Published
2023
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19. The utility of zebrafish cardiac arrhythmia model to predict the pathogenicity of KCNQ1 variants

Author

Cui, Shihe, Hayashi, Kenshi, Kobayashi, Isao, Hosomichi, Kazuyoshi, Nomura, Akihiro, Teramoto, Ryota, Usuda, Keisuke, Okada, Hirofumi, Deng, Yaowen, Kobayashi-Sun, Jingjing, Nishikawa, Tetsuo, Furusho, Hiroshi, Saito, Takekatsu, Hirase, Hiroaki, Ohta, Kunio, Fujimoto, Manabu, Horita, Yuki, Kusayama, Takashi, Tsuda, Toyonobu, Tada, Hayato, Kato, Takeshi, Usui, Soichiro, Sakata, Kenji, Fujino, Noboru, Tajima, Atsushi, Yamagishi, Masakazu, and Takamura, Masayuki

Published
2023
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26. Impact of sinus rhythm maintenance on major adverse cardiac and cerebrovascular events after catheter ablation of atrial fibrillation: insights from AF frontier ablation registry

Author

Usuda, Keisuke, Kato, Takeshi, Tsuda, Toyonobu, Tada, Hayato, Niwa, Satoru, Usui, Soichiro, Sakata, Kenji, Hayashi, Kenshi, Furusho, Hiroshi, Kawashiri, Masaaki, Takamura, Masayuki, Otsuka, Takayuki, Suzuki, Shinya, Hirata, Akio, Murakami, Masato, Takami, Mitsuru, Kimura, Masaomi, Fukaya, Hidehira, Nakahara, Shiro, Shimizu, Wataru, Iwasaki, Yu-ki, Hayashi, Hiroshi, Harada, Tomoo, Nakajima, Ikutaro, Okumura, Ken, Koyama, Junjiroh, Tokuda, Michifumi, Yamane, Teiichi, Momiyama, Yukihiko, Tanimoto, Kojiro, Soejima, Kyoko, Nonoguchi, Noriko, Ejima, Koichiro, Hagiwara, Nobuhisa, Harada, Masahide, Sonoda, Kazumasa, Inoue, Masaru, Kumagai, Koji, Hayashi, Hidemori, Satomi, Kazuhiro, Yazaki, Yoshinao, Watari, Yuji, Arai, Masaru, Watanabe, Ryuta, Yokoyama, Katsuaki, Matsumoto, Naoya, Nagashima, Koichi, and Okumura, Yasuo

Published
2022
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29. Cardiac sympathetic activity and lethal arrhythmic events: insight into bell-shaped relationship between 123I-meta-iodobenzylguanidine activity and event rates.

Author

Nakajima, Kenichi, Nakata, Tomoaki, Doi, Takahiro, Verschure, Derk O., Frantellizzi, Viviana, De Feo, Maria Silvia, Tada, Hayato, and Verberne, Hein J.

Subjects
ARRHYTHMIA, CARDIAC pacing, CARDIAC arrest, VENTRICULAR tachycardia, HEART failure patients, CARDIAC resuscitation
Abstract

Background: 123I-meta-iodobenzylguanidine (mIBG) has been applied to patients with chronic heart failure (CHF). However, the relationship between 123I-mIBG activity and lethal arrhythmic events (ArE) is not well defined. This study aimed to determine this relationship in Japanese and European cohorts. Results: We calculated heart-to-mediastinum (H/M) count ratios and washout rates (WRs) of 827 patients using planar 123I-mIBG imaging. We defined ArEs as sudden cardiac death, arrhythmic death, and potentially lethal events such as sustained ventricular tachycardia, cardiac arrest with resuscitation, and appropriate implantable cardioverter defibrillator (ICD) discharge, either from a single ICD or as part of a cardiac resynchronization therapy device (CRTD). We analyzed the incidence of ArE with respect to H/M ratios, WRs and New York Heart Association (NYHA) functional classes among Japanese (J; n = 581) and European (E; n = 246) cohorts. We also simulated ArE rates versus H/M ratios under specific conditions using a machine-learning model incorporating 13 clinical variables. Consecutive patients with CHF were selected in group J, whereas group E comprised candidates for cardiac electronic devices. Groups J and E mostly comprised patients with NYHA functional classes I/II (95%) and II/III (91%), respectively, and 21% and 72% were respectively implanted with ICD/CRTD devices. The ArE rate increased with lower H/M ratios in group J, but the relationship was bell-shaped, with a high ArE rate within the intermediate H/M range, in group E. This bell-shaped curve was also evident in patients with NYHA classes II/III in the combined J and E groups, particularly in those with a high (> 15%) mIBG WR and with ischemic, but not in those with non-ischemic etiologies. Machine learning-based prediction of ArE risk aligned with these findings, indicating a bell-shaped curve in NYHA class II/III but not in class I. Conclusions: The relationship between cardiac 123I-mIBG activity and lethal arrhythmic events is influenced by the background of patients. The bell-shaped relationship in NYHA classes II/III, high WR, and ischemic etiology likely aids in identifying patients at high risk for ArEs. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Sitosterolemia

Author

Tada, Hayato, primary, Kojima, Nobuko, additional, Takamura, Masayuki, additional, and Kawashiri, Masa-aki, additional

Published
2022
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34. Transitional Medicine of Intractable Primary Dyslipidemias in Japan

Author

Ogura, Masatsune, primary, Okazaki, Sachiko, additional, Okazaki, Hiroaki, additional, Tada, Hayato, additional, Dobashi, Kazushige, additional, Nakamura, Kimitoshi, additional, Matsunaga, Keiji, additional, Miida, Takashi, additional, Minamino, Tetsuo, additional, Yokoyama, Shinji, additional, and Harada-Shiba, Mariko, additional

Published
2024
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36. Improved Efficiency of the Clinical Diagnostic Criteria for Familial Hypercholesterolemia in Children: A Comparison of the Japan Atherosclerosis Society Guidelines of 2017 and 2022

Author

Fu, Hai Ying, primary, Matsunaga, Keiji, additional, Inoue, Tomoko, additional, Tani, Ryosuke, additional, Funatsuki, Kenzo, additional, Iwase, Takashi, additional, Kondo, Sonoko, additional, Nishioka, Katsufumi, additional, Ito, Shigeru, additional, Sasaki, Tsuyoshi, additional, Yokota, Ichiro, additional, Hoshikawa, Yoichi, additional, Yokoyama, Katsunori, additional, Fujisawa, Takuji, additional, Kawashiri, Masa-aki, additional, Tada, Hayato, additional, Takamura, Masayuki, additional, Kusaka, Takashi, additional, and Minamino, Tetsuo, additional

Published
2024
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39. Correction: Characterization of baseline clinical factors associated with incident worsening kidney function in patients with non-valvular atrial fibrillation: the Hokuriku-Plus AF Registry

Author

Hayashi, Kenshi, Tanaka, Yoshihiro, Tsuda, Toyonobu, Nomura, Akihiro, Fujino, Noboru, Furusho, Hiroshi, Sakai, Norihiko, Iwata, Yasunori, Usui, Soichiro, Sakata, Kenji, Kato, Takeshi, Tada, Hayato, Kusayama, Takashi, Usuda, Keisuke, Kawashiri, Masa-aki, Passman, Rod S., Wada, Takashi, Yamagishi, Masakazu, and Takamura, Masayuki

Published
2023
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41. Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease

Author

Nomura, Akihiro, Won, Hong-Hee, Khera, Amit V, Takeuchi, Fumihiko, Ito, Kaoru, McCarthy, Shane, Emdin, Connor A, Klarin, Derek, Natarajan, Pradeep, Zekavat, Seyedeh M, Gupta, Namrata, Peloso, Gina M, Borecki, Ingrid B, Teslovich, Tanya M, Asselta, Rosanna, Duga, Stefano, Merlini, Piera A, Correa, Adolfo, Kessler, Thorsten, Wilson, James G, Bown, Matthew J, Hall, Alistair S, Braund, Peter S, Carey, David J, Murray, Michael F, Kirchner, H Lester, Leader, Joseph B, Lavage, Daniel R, Manus, J Neil, Hartze, Dustin N, Samani, Nilesh J, Schunkert, Heribert, Marrugat, Jaume, Elosua, Roberto, McPherson, Ruth, Farrall, Martin, Watkins, Hugh, Juang, Jyh-Ming J, Hsiung, Chao A, Lin, Shih-Yi, Wang, Jun-Sing, Tada, Hayato, Kawashiri, Masa-Aki, Inazu, Akihiro, Yamagishi, Masakazu, Katsuya, Tomohiro, Nakashima, Eitaro, Nakatochi, Masahiro, Yamamoto, Ken, Yokota, Mitsuhiro, Momozawa, Yukihide, Rotter, Jerome I, Lander, Eric S, Rader, Daniel J, Danesh, John, Ardissino, Diego, Gabriel, Stacey, Willer, Cristen J, Abecasis, Goncalo R, Saleheen, Danish, Kubo, Michiaki, Kato, Norihiro, Ida Chen, Yii-Der, Dewey, Frederick E, and Kathiresan, Sekar

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Atherosclerosis, Heart Disease - Coronary Heart Disease, Heart Disease, Cardiovascular, Genetics, Adult, Aged, Case-Control Studies, Cholesterol Ester Transfer Proteins, Coronary Disease, Female, Genetic Variation, Humans, Male, Middle Aged, Risk Factors, case-control studies, cholesteryl ester transfer protein, coronary disease, lipids, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

RationaleTherapies that inhibit CETP (cholesteryl ester transfer protein) have failed to demonstrate a reduction in risk for coronary heart disease (CHD). Human DNA sequence variants that truncate the CETP gene may provide insight into the efficacy of CETP inhibition.ObjectiveTo test whether protein-truncating variants (PTVs) at the CETP gene were associated with plasma lipid levels and CHD.Methods and resultsWe sequenced the exons of the CETP gene in 58 469 participants from 12 case-control studies (18 817 CHD cases, 39 652 CHD-free controls). We defined PTV as those that lead to a premature stop, disrupt canonical splice sites, or lead to insertions/deletions that shift frame. We also genotyped 1 Japanese-specific PTV in 27561 participants from 3 case-control studies (14 286 CHD cases, 13 275 CHD-free controls). We tested association of CETP PTV carrier status with both plasma lipids and CHD. Among 58 469 participants with CETP gene-sequencing data available, average age was 51.5 years and 43% were women; 1 in 975 participants carried a PTV at the CETP gene. Compared with noncarriers, carriers of PTV at CETP had higher high-density lipoprotein cholesterol (effect size, 22.6 mg/dL; 95% confidence interval, 18-27; P

Published
2017

42. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis

Author

Natarajan, Pradeep, Bis, Joshua C, Bielak, Lawrence F, Cox, Amanda J, Dörr, Marcus, Feitosa, Mary F, Franceschini, Nora, Guo, Xiuqing, Hwang, Shih-Jen, Isaacs, Aaron, Jhun, Min A, Kavousi, Maryam, Li-Gao, Ruifang, Lyytikäinen, Leo-Pekka, Marioni, Riccardo E, Schminke, Ulf, Stitziel, Nathan O, Tada, Hayato, van Setten, Jessica, Smith, Albert V, Vojinovic, Dina, Yanek, Lisa R, Yao, Jie, Yerges-Armstrong, Laura M, Amin, Najaf, Baber, Usman, Borecki, Ingrid B, Carr, J Jeffrey, Chen, Yii-Der Ida, Cupples, L Adrienne, de Jong, Pim A, de Koning, Harry, de Vos, Bob D, Demirkan, Ayse, Fuster, Valentin, Franco, Oscar H, Goodarzi, Mark O, Harris, Tamara B, Heckbert, Susan R, Heiss, Gerardo, Hoffmann, Udo, Hofman, Albert, Išgum, Ivana, Jukema, J Wouter, Kähönen, Mika, Kardia, Sharon LR, Kral, Brian G, Launer, Lenore J, Massaro, Joe, Mehran, Roxana, Mitchell, Braxton D, Mosley, Thomas H, de Mutsert, Renée, Newman, Anne B, Nguyen, Khanh-Dung, North, Kari E, O'Connell, Jeffrey R, Oudkerk, Matthijs, Pankow, James S, Peloso, Gina M, Post, Wendy, Province, Michael A, Raffield, Laura M, Raitakari, Olli T, Reilly, Dermot F, Rivadeneira, Fernando, Rosendaal, Frits, Sartori, Samantha, Taylor, Kent D, Teumer, Alexander, Trompet, Stella, Turner, Stephen T, Uitterlinden, Andre G, Vaidya, Dhananjay, van der Lugt, Aad, Völker, Uwe, Wardlaw, Joanna M, Wassel, Christina L, Weiss, Stefan, Wojczynski, Mary K, Becker, Diane M, Becker, Lewis C, Boerwinkle, Eric, Bowden, Donald W, Deary, Ian J, Dehghan, Abbas, Felix, Stephan B, Gudnason, Vilmundur, Lehtimäki, Terho, Mathias, Rasika, Mook-Kanamori, Dennis O, Psaty, Bruce M, Rader, Daniel J, Rotter, Jerome I, Wilson, James G, van Duijn, Cornelia M, Völzke, Henry, Kathiresan, Sekar, Peyser, Patricia A, and O'Donnell, Christopher J

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Heart Disease - Coronary Heart Disease, Aging, Human Genome, Atherosclerosis, Cardiovascular, Heart Disease, Clinical Research, Genetics, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being, Apolipoprotein B-100, Apolipoprotein E2, Asymptomatic Diseases, Black People, Carotid Artery Diseases, Carotid Intima-Media Thickness, Cholesterol, LDL, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Exome, Gene Frequency, Genetic Markers, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Odds Ratio, Oligonucleotide Array Sequence Analysis, Phenotype, Prognosis, Risk Assessment, Risk Factors, Vascular Calcification, White People, carotid intima-media thickness, coronary artery calcification, exome, genome-wide association study, genomics, CHARGE Consortium, carotid intima–media thickness, Medical Biotechnology, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundThe burden of subclinical atherosclerosis in asymptomatic individuals is heritable and associated with elevated risk of developing clinical coronary heart disease. We sought to identify genetic variants in protein-coding regions associated with subclinical atherosclerosis and the risk of subsequent coronary heart disease.Methods and resultsWe studied a total of 25 109 European ancestry and African ancestry participants with coronary artery calcification (CAC) measured by cardiac computed tomography and 52 869 participants with common carotid intima-media thickness measured by ultrasonography within the CHARGE Consortium (Cohorts for Heart and Aging Research in Genomic Epidemiology). Participants were genotyped for 247 870 DNA sequence variants (231 539 in exons) across the genome. A meta-analysis of exome-wide association studies was performed across cohorts for CAC and carotid intima-media thickness. APOB p.Arg3527Gln was associated with 4-fold excess CAC (P=3×10-10). The APOE ε2 allele (p.Arg176Cys) was associated with both 22.3% reduced CAC (P=1×10-12) and 1.4% reduced carotid intima-media thickness (P=4×10-14) in carriers compared with noncarriers. In secondary analyses conditioning on low-density lipoprotein cholesterol concentration, the ε2 protective association with CAC, although attenuated, remained strongly significant. Additionally, the presence of ε2 was associated with reduced risk for coronary heart disease (odds ratio 0.77; P=1×10-11).ConclusionsExome-wide association meta-analysis demonstrates that protein-coding variants in APOB and APOE associate with subclinical atherosclerosis. APOE ε2 represents the first significant association for multiple subclinical atherosclerosis traits across multiple ethnicities, as well as clinical coronary heart disease.

Published
2016

43. Tackling cardiometabolic risk in the Asia Pacific region

Author

Li, Jian-Jun, Yeo, Khung Keong, Tan, Kathyrn, Ako, Junya, Krittayaphong, Rungroj, Tan, Ru San, Aylward, Philip E., Lam, CarolynS.P., Baek, Sang Hong, Dalal, Jamshed, Fong, Alan, Li, Yi-Heng, O’Brien, Richard C., Koh, Si Ya Natalie, Scherer, Daniel J., Tada, Hayato, Kang, Vernon, Butters, Julie, and Nicholls, Stephen J.

Published
2020
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50. A case of sitosterolemia-caused systemic large-vessel stenosis mimicking Takayasu arteritis in which FDG-PET provided a clue for the differential diagnosis

Author

Nakadoi, Takato, primary, Katsuyama, Eri, additional, Matsumoto, Kazuya, additional, Shidahara, Kenta, additional, Hirose, Kei, additional, Nawachi, Shoichi, additional, Asano, Yosuke, additional, Katayama, Yu, additional, Miyawaki, Yoshia, additional, Katsuyama, Takayuki, additional, Takano-Narazaki, Mariko, additional, Matsumoto, Yoshinori, additional, Sada, Ken-Ei, additional, Tada, Hayato, additional, and Wada, Jun, additional

Published
2023
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