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5 results on '"Tackett, Karen"'

1. Acute GVHD, BK virus hemorrhagic cystitis and age are risk factors for transplant-associated thrombotic microangiopathy in adults

Author

Vasu, Sumithira, Bostic, Matthew, Zhao, Qiuhong, Sharma, Nidhi, Puto, Marcin, Knight, Samantha, Scott, Denise, Guzman, Rosalyn, Kromer, Meghan, Tackett, Karen, Lind, Kristin, Knill, Kathryn, Watson, Emily, Wall, Sarah, Saad, Ayman, Choe, Hannah, Larkin, Karilyn, Brammer, Jonathan, Jaglowski, Samantha, Penza, Sam, Davies, Stella M., and Cataland, Spero

Published
2022
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2. G-CSF improves safety when you start the day after autologous transplant in multiple myeloma

Author

Sborov, Douglas W., primary, Cho, Yu Kyoung, additional, Cottini, Francesca, additional, Hade, Erinn M., additional, Lamprecht, Misty, additional, Tackett, Karen, additional, Sharma, Nidhi, additional, Williams, Nita, additional, Li, Junan, additional, Devine, Steven, additional, Poi, Ming, additional, Phelps, Mitch A., additional, and Hofmeister, Craig C., additional

Published
2017
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5. Acute GVHD, BK hemorrhagic cystitis and age are risk factors for transplant-associated thrombotic microangiopathy in adults

Author

Vasu, Sumithira, Bostic, Matthew, Zhao, Qiuhong, Sharma, Nidhi, Puto, Marcin, Knight, Samantha, Scott, Denise, Guzman, Rosalyn, Kromer, Meghan, Tackett, Karen, Lind, Kristin, Knill, Kathryn, Watson, Emily, Wall, Sarah, Saad, Ayman, Choe, Hannah, Larkin, Karilyn, Brammer, Jonathan, Jaglowski, Samantha, Penza, Sam, Davies, Stella M, and Cataland, Spero

Abstract

Hematopoietic cell transplantation associated thrombotic microangiopathy (TMA) is a complication associated with higher non-relapse mortality (NRM) in allogeneic transplant (HCT) patients. Current classification criteria are not generally agreed upon or validated, and presence of confounding factors post-transplant contribute to under-diagnosis or delayed diagnosis of TMA. We studied risk factors, incidence and biomarkersof TMA in 119 adult allogeneic HCT recipients.Twenty-seven patients developed clinically actionable phenotype of TMA (CA-TMA) and the incidence of CA-TMA was 22% by day 180. Among the 27 patients that developed CA-TMA, 10 patients developed CA-TMA prior to onset of acute graft-versus-host disease (aGVHD) and 17 patients developed CA-TMA after the onset of aGVHD. We report for the first time that age > 50, BK hemorrhagic cystitis) and other viral infections (CMV, HHV-6, Adenovirus) are risk factors for adult CA-TMA. Even after adjusting for aGVHD, CA-TMA was independently associated with significantly higher non-relapse mortality.These data illustrate relationships between CA-TMA and aGVHD, describe new risk factors for CA-TMA and emphasizes theneed to develop validated set of criteria for timely diagnosis.

Published
2021
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