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298 results on '"Tabish, Tanveer A."'

2. Contributors

Author

Abbas, Manzar, primary, Ahmad, Jalal, additional, Akhtar, Mahmood Hassan, additional, Andleeb, Farah, additional, Arockiaraj, Jesu, additional, Atiq, Atia, additional, Atiq, Maria, additional, Banerjee, Jhimli, additional, Bao, Jianwei, additional, Bukhari, Syeda Zunaira, additional, Dash, Sandeep Kumar, additional, Hussain, Sajid, additional, Idrees, Sana, additional, Iftikhar, Maryam, additional, Ihsan, Ayesha, additional, Ijaz, Shumaila, additional, Iqbal, Javed, additional, Irshad, Kanwal, additional, Khalil, Ali Talha, additional, Khan, Hasan. M., additional, Manjusha, Muralidharan, additional, Mir, Tanveer Ahmad, additional, Mukherjee, Sudip, additional, Ovais, Muhammad, additional, Pramanik, Arindam, additional, Rafiq, Farhat, additional, Saleem, Muhammad, additional, Samanta, Sovan, additional, Saravanan, Muthupandian, additional, Shabbir, Maryam, additional, Shahid, Syed Ahsan, additional, Sravanthy, Geetha, additional, Tabish, Tanveer A., additional, Ullah, Sana, additional, Vydiam, Kalyan, additional, Yasasve, Madhavan, additional, Younas, Maira, additional, Younis, Muhammad Rizwan, additional, Yu, Cong, additional, Zou, Qianli, additional, khan, Maroof Ahmad, additional, and UR Rehman, Saeed, additional

Published
2024
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8. Biosensing Applications of MXene-Based Composites

Author

Sharif, Ayesha, Khan, Shahzad Maqsood, Tabish, Tanveer A., Gull, Nafisa, Zia, Saba, Husen, Azamal, Series Editor, Jawaid, Mohammad, Series Editor, Rizwan, Komal, editor, Khan, Anish, editor, and Ahmed Asiri, Abdullah Mohammed, editor

Published
2023
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21. Development of graphene nanostructures for use in anti-cancer nanomedicine

Author

Tabish, Tanveer Ahmad, Zhang, Shaowei, and Xia, Yongde

Subjects
610.28, Graphene, nanomedicine, cancer diagnosis and treatment
Abstract

Nanomedicine utilises biocompatible nanomaterials for therapeutic as well as imaging purposes, for the treatment of various diseases including cancer, neurological disorders and wound infections. Graphene, a material composed of a single layer of carbon atoms, has recently shown great potential to improve diagnostics and therapeutics, owing to its small size, large surface-area-to-volume ratio and unique physicochemical properties. However, the limited fabrication, in vitro and in vivo functionalities published in the literature indicate inconsistencies regarding the factors affecting metabolic fate, biodistribution as well as toxicity patterns of graphene. This thesis focuses on the biological effects of graphene-based materials, including graphene oxide (GO), reduced graphene oxide (rGO), graphene nanopores (GNPs), graphene quantum dots (GQDs) and three-dimensional graphene foam (GF). These can be used to closely mimic therapeutic functions and thereby open up new pathways to anticancer nanomedicine. In this work, a biocompatible GO-based anti-metastatic enzyme cancer therapy approach has been introduced for the first time to target the extracellular pro-metastatic and pro- tumourigenic enzymes of cathepsin D and cathepsin L, which are typically overexpressed in ovarian and breast cancers. Definitive binding and modulation of cathepsin- D and -L with GO has revealed that both of the enzymes were adsorbed onto the surface of GO through its cationic and hydrophilic residues under the biologically relevant condition of acidic pH. It has been demonstrated that low concentrations of rGO were shown to significantly produce late apoptosis and necrosis rather than early apoptotic events in lung cancer cells (A549 and SKMES-1), suggesting that it was able to disintegrate the cellular membranes in a dose-dependent manner. GNPs at lower concentrations (250μg/ml) induce upregulation of phosphatidylserine on cell surface membrane (i.e. early apoptotic event), which does not significantly disintegrate the cell membrane in the aforementioned lung cancer cells, while higher concentrations of GNPs (5 and 15 mg/kg) in rats (when intraperitoneally injected) exhibited sub-chronic toxicity in a period of 27 days. The interaction of GQDs and trypsin has revealed the strong bonding capacity of GQDs with trypsin, owing to their surface charge and surface functionalities evidencing the high bioavailability of GQDs in enzyme engineering. Finally, 3D GF was developed to probe the role of graphene-based scaffold cues in the field of regenerative medicine revealing their cell attachment to in vitro cell cultures. Furthermore, GF was shown to maintain remarkable biocompatibility with in vitro and in vivo toxicity screening models when exposed for 7 days at doses of 5, 10 and 15 mg/l. Taken together, graphene and its modified structures developed in this thesis promise to revolutionise clinical settings across the board in nanomedicine which include, but are not limited to, ultra-high sensitive enzyme adsorbents, high throughput biosensors, enzyme modulators and smart scaffolds for tissue regeneration.

Published
2018

22. Synthesis and characterization of amine-functionalized graphene as a nitric oxide-generating coating for vascular stents.

Author

Tabish, Tanveer A., Hussain, Mian Zahid, Zhu, Yangzhi, Xu, Jiabao, Huang, Wei E., Diotallevi, Marina, Narayan, Roger J., Crabtree, Mark J., Khademhosseini, Ali, Winyard, Paul G., and Lygate, Craig A.

Subjects
*FOURIER transform infrared spectroscopy, *CORONARY artery disease, *GRAPHENE oxide, *ACCELERATED life testing, *POLYETHYLENE glycol, *POLYLACTIC acid, *POLYETHYLENEIMINE
Abstract

Drug-eluting stents are commonly utilized for the treatment of coronary artery disease, where they maintain vessel patency and prevent restenosis. However, problems with prolonged vascular healing, late thrombosis, and neoatherosclerosis persist; these could potentially be addressed via the local generation of nitric oxide (NO) from endogenous substrates. Herein, we develop amine-functionalized graphene as a NO-generating coating on polylactic acid (PLA)-based bioresorbable stent materials. A novel catalyst was synthesized consisting of polyethyleneimine and polyethylene glycol bonded to graphene oxide (PEI-PEG@GO), with physicochemical characterization using x-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis. In the presence of 10 μM S-nitrosoglutathione (GSNO) or S-nitroso-N-acetylpenicillamine (SNAP), PEI-PEG@GO catalyzed the generation of 62% and 91% of the available NO, respectively. Furthermore, PEI-PEG@GO enhanced and prolonged real-time NO generation from GSNO and SNAP under physiological conditions. The uniform coating of PEI-PEG@GO onto stent material is demonstrated via an optimized simple dip-coating method. The coated PLA maintains good biodegradability under accelerated degradation testing, while the PEI-PEG@GO coating remains largely intact. Finally, the stability of the coating was demonstrated at room temperature over 60 days. In conclusion, the innovative conjugation of polymeric amines with graphene can catalyze the generation of NO from S-nitrosothiols at physiologically relevant concentrations. This approach paves the way for the development of controlled NO-generating coatings on bioresorbable stents in order to improve outcomes in coronary artery disease. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Graphene nanocomposites for real-time electrochemical sensing of nitric oxide in biological systems.

Author

Tabish, Tanveer A., Zhu, Yangzhi, Shukla, Shubhangi, Kadian, Sachin, Sangha, Gurneet S., Lygate, Craig A., and Narayan, Roger J.

Subjects
*BIOLOGICAL systems, *GRAPHENE, *NITRIC oxide, *NANOCOMPOSITE materials, *ELECTRON mobility, *CELL sheets (Biology)
Abstract

Nitric oxide (NO) signaling plays many pivotal roles impacting almost every organ function in mammalian physiology, most notably in cardiovascular homeostasis, inflammation, and neurological regulation. Consequently, the ability to make real-time and continuous measurements of NO is a prerequisite research tool to understand fundamental biology in health and disease. Despite considerable success in the electrochemical sensing of NO, challenges remain to optimize rapid and highly sensitive detection, without interference from other species, in both cultured cells and in vivo. Achieving these goals depends on the choice of electrode material and the electrode surface modification, with graphene nanostructures recently reported to enhance the electrocatalytic detection of NO. Due to its single-atom thickness, high specific surface area, and highest electron mobility, graphene holds promise for electrochemical sensing of NO with unprecedented sensitivity and specificity even at sub-nanomolar concentrations. The non-covalent functionalization of graphene through supermolecular interactions, including π–π stacking and electrostatic interaction, facilitates the successful immobilization of other high electrolytic materials and heme biomolecules on graphene while maintaining the structural integrity and morphology of graphene sheets. Such nanocomposites have been optimized for the highly sensitive and specific detection of NO under physiologically relevant conditions. In this review, we examine the building blocks of these graphene-based electrochemical sensors, including the conjugation of different electrolytic materials and biomolecules on graphene, and sensing mechanisms, by reflecting on the recent developments in materials and engineering for real-time detection of NO in biological systems. [ABSTRACT FROM AUTHOR]

Published
2023
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