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319 results on '"Tabata, Chiharu"'

1. Possible Association of CD3+CD4−CD8− Phenotype of T-Cell Lymphoma with Peripheral Blood Eosinophilia.

Author

Tabata, Rie and Tabata, Chiharu

Subjects
*T-cell lymphoma, *IMMUNOHISTOCHEMISTRY, *EOSINOPHILIA, *EOSINOPHILS, *LYMPHOMAS, *SEZARY syndrome, *HYPEREOSINOPHILIC syndrome
Abstract

Introduction: Because the prognosis of patients with peripheral T-cell lymphoma is poor compared to that of patients with B-cell lymphoma, we want to avoid further organ damage by eosinophilia. Moreover, in patients with some types of lymphoma, blood eosinophilia is implicated in a worse prognosis. To study the risk factors of eosinophilia, the association between lymphoma type, immunophenotypic features, and peripheral blood eosinophil counts were examined in the patients with mature T-cell lymphoma. Methods: We retrospectively examined 28 patients with mature T-cell lymphoma who were admitted to our hospital and whose immunophenotypic features were confirmed using flow cytometric, immunohistochemical analysis, or both between December 2012 and November 2023. Results: We report a possible association between peripheral eosinophilia and peripheral T-cell lymphoma – not otherwise specified and CD3+CD4−D8− (double-negative) phenotypes. Mild eosinophilia was observed in various types, but moderate and severe eosinophilia were observed in patients with peripheral T-cell lymphoma – not otherwise specified. Double-negative phenotype was rarely observed; however, all patients with double-negative phenotype exhibited peripheral blood eosinophilia. In addition, four of the five cases of the double-negative type were peripheral T-cell lymphoma – not otherwise specified. Conclusion: Here, we retrospectively examined patients with peripheral T-cell lymphoma whose immunophenotypic features were confirmed and report a possible association between peripheral eosinophilia and peripheral T-cell lymphoma – not otherwise specified and CD3+CD4−CD8− (double-negative) phenotypes. In addition, clinicians should be aware of the possible risk that patients with lymphocytic hypereosinophilic syndrome of the double-negative phenotype may develop peripheral T-cell lymphoma. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Possible risk of interstitial lung diseases in myelodysplastic syndrome patients with chromosome der(1;7)(q10;p10) and/or +8 during azacitidine therapy.

Author

Tabata, Rie and Tabata, Chiharu

Subjects
*IDIOPATHIC interstitial pneumonias, *INTERSTITIAL lung diseases, *MYELODYSPLASTIC syndromes, *AZACITIDINE, *CHROMOSOMES, *ACUTE myeloid leukemia
Abstract

This article discusses a study that examined the risk of interstitial lung diseases (ILDs) in patients with myelodysplastic syndrome (MDS) undergoing azacitidine therapy. The study found suggestive findings for ILD in three patients out of 73 with MDS or acute myeloid leukaemia (AML) with myelodysplasia-related changes (MRCs). These patients were diagnosed with ILD based on tests and examinations. The study suggests that patients with MDS and specific chromosomal abnormalities may be at a higher risk of developing ILD during azacitidine therapy, but further research is needed to confirm these findings. Clinicians should exercise caution when considering azacitidine therapy for these patients. [Extracted from the article]

Published
2024
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5. A randomized phase III study of docetaxel alone versus docetaxel plus S‐1 in patients with previously treated non‐small cell lung cancer: JMTO LC09‐01

Author

Atagi, Shinji, primary, Daimon, Takashi, additional, Okishio, Kyoichi, additional, Komuta, Kiyoshi, additional, Okano, Yoshio, additional, Minato, Koichi, additional, Kim, Young Hak, additional, Usui, Ryo, additional, Tabata, Chiharu, additional, Tamura, Atsuhisa, additional, and Kawahara, Masaaki, additional

Published
2023
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26. All-trans retinoic acid modulates radiation-induced proliferation of lung fibroblasts via IL-6/IL-6R system

Author

Tabata, Chiharu, Kubo, Hajime, Tabata, Rie, Wada, Manabu, Sakuma, Keiichiro, Ichikawa, Masataka, Fujita, Shiro, Mio, Tadashi, and Mishima, Michiaki

Subjects
Bacterial pneumonia -- Research, Bacterial pneumonia -- Health aspects, Pneumonia -- Research, Pneumonia -- Health aspects, Fibroblasts -- Research, Tretinoin -- Research, Cytokine receptors -- Research, Pulmonary fibrosis -- Research, Biological sciences
Abstract

Although high-dose thoracic radiotherapy is an effective strategy for some malignancies including lung cancers and malignant lymphomas, it often causes complications of radiation fibrosis. To study the mechanism initiating tissue fibrosis, we investigated irradiation-induced cytokine production from human lung fibroblastic cells and found that IL-6 production was stimulated by irradiation. IL-6 is an autocrine growth factor for human myeloma cells, and retinoic acid is reported to inhibit their growth. Thus we evaluated the effect of all-trans retinoic acid (ATRA) on cell proliferation of lung fibroblasts along with the cytokine/receptor system. Irradiation-dependent stimulation of IL-6 production was correlated with increased NF-[kappa]B activity, and ATRA reduced this effect. Irradiation also increased the levels of mRNA for IL-6R and gp130, which were blocked by coexisting ATRA. Furthermore, IL-6 stimulated cell proliferation in dose-dependent manner but was overcome by pharmacological concentration of ATRA. These effects of ATRA were inhibited by rottlerin, which suggests ATRA abolished irradiation-induced stimulation through a PKC[delta]-dependent pathway. Finally, we demonstrated that IL-6 transcripts in the lung were upregulated at 2 mo after irradiation, and the effect was inhibited by the intraperitoneal administration of ATRA. ATRA is expected to have an advantage for radiotherapy in its antitumor effects, as reported previously, and to prevent radiotherapy-induced pulmonary injury. lung fibrosis; radiation pneumonitis; cytokines; cytokine receptors; interleukin-6 receptor

Published
2006

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