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5. Using solution-focused pupil support meetings (SFPSMs) to support pupils identified as having social, emotional and behavioural difficulties (SEBD) : early intervention at the Year 6/7 transition phase

Author

Tabassum, Nadia, Atkinson, Cathy, and Bond, Caroline

Subjects
370.15
Abstract

Background: Historically, person-centred planning (PCP) reviews were (and still are) used within the health and social care field (Department of Health, 2009). However, more recently this is an approach that has been used within education, and more recently, for individuals identified as having Social, Emotional and, Behavioural Difficulties (SEBD) (Taylor-Brown, 2012). The current research drew upon PCP, solution-focused approaches (Alexander & Sked, 2010) and visual reviews (Hayes, 2004) to develop solution-focused pupil support meetings (SFPSMs). The aim was to look at the ‘process’ and evaluation of the SFPSMs from the perspective of the child and young person (CYP), school staff, professionals and the Senior Specialist Educational Psychologist (SSEP) to ascertain the facilitators and barriers to the approach in order to improve and develop the approach further.Participants: 3 pupils (Year 6) and their key worker (KW) in school, key [other] professional and the co-ordinating SSEP, which gave a total of 9 participants.Methods: A case study design was employed using semi-structured interviews with pupils at 3 phases (pre, post and follow up) and with school staff, professionals and the SSEP at the follow up stage.Analysis/ Findings: Qualitative data were thematically analysed. The 3 case studies present some initial positive findings for the use of SFPSMs and identify areas for further development of the approach.Conclusion/implications: Findings are discussed in relation to implications for the Educational Psychology Service, school practice and the Local Authority.

Published
2013

22. Status of Bioinformatics Education in South Asia: Past and Present

Author

Ali, Muhammad Muddassir, Hamid, Muhammad, Saleem, Muhammad, Malik, Saadia, Mian, Natash Ali, Ihsan, Muhammad Ahmed, Tabassum, Nadia, Mehmood, Khalid, and Awan, Furqan

Subjects
Article Subject
Abstract

Bioinformatics education has been a hot topic in South Asia, and the interest in this education peaks with the start of the 21st century. The governments of South Asian countries had a systematic effort for bioinformatics. They developed the infrastructures to provide maximum facility to the scientific community to gain maximum output in this field. This article renders bioinformatics, measures, and its importance of implementation in South Asia with proper ways of improving bioinformatics education flaws. It also addresses the problems faced in South Asia and proposes some recommendations regarding bioinformatics education. The information regarding bioinformatics education and institutes was collected from different existing research papers, databases, and surveys. The information was then confirmed by visiting each institution’s website, while problems and solutions displayed in the article are mostly in line with South Asian bioinformatics conferences and institutions’ objectives. Among South Asian countries, India and Pakistan have developed infrastructure and education regarding bioinformatics rapidly as compared to other countries, whereas Bangladesh, Sri Lanka, and Nepal are still in a progressing phase in this field. To advance in a different sector, the bioinformatics industry has to be revolutionized, and it will contribute to strengthening the pharmaceutical, agricultural, and molecular sectors in South Asia. To advance in bioinformatics, universities’ infrastructure needs to be on a par with the current international standards, which will produce well-trained professionals with skills in multiple fields like biotechnology, mathematics, statistics, and computer science. The bioinformatics industry has revolutionized and strengthened the pharmaceutical, agricultural, and molecular sectors in South Asia, and it will serve as the standard of education increases in the South Asian countries. A framework for developing a centralized database is suggested after the literature review to collect and store the information on the current status of South Asian bioinformatics education. This will be named as the South Asian Bioinformatics Education Database (SABE). This will provide comprehensive information regarding the bioinformatics in South Asian countries by the country name, the experts of this field, and the university name to explore the top-ranked outputs relevant to queries.

Published
2021
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29. Intelligent reliability management in hyper-convergence cloud infrastructure using fuzzy inference system.

Author

Tabassum, Nadia, Khan, Muhammad Saleem, Abbas, Sagheer, Alyas, Tahir, Athar, Atifa, and Khan, Muhammad Adnan

Subjects
CLOUD computing, NETWORK failures (Telecommunication), COMPUTER hacking, VIRTUAL machine systems, RELIABILITY in engineering
Abstract

Hyper-convergence is a new innovation in data center technology, it changes the way clouds manage and maintain enterprise IT infrastructure. Hyper-convergence is more efficient and basically agile technology environment. Cloud computing is a latest technology due to provision of latest cloud services over the internet. The cloud service providers cannot promise accurate reliability of their services i.e. problem in provisioning of software or hardware failure etc. Reliability of cloud computing services depends on the ability of fault tolerance during the execution of services. There are so many factors can cause faults, such as network failure, browser crash, request time out or hacker attacks. When users are facing these types of faults, they usually resubmit their requests. However, if there is any key element involved in faults or errors, additional action may be needed to deal with system logs. If there is anomaly behavior occurred in faulted virtual machine, these VMs may need extra attention from cloud system protection and security point of view. In this paper, provision of reliability management in hyper-convergence cloud infrastructure is proposed and self-healing techniques in software as a service on the basis of failure in cloud services. Intelligent cloud service reliability framework will increase the reliability during execution of cloud service. [ABSTRACT FROM AUTHOR]

Published
2019
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31. Isolation and Characterization of Isofraxidin 7-O-(6′-O-p-Coumaroyl)-β-glucopyranoside fromArtemisia capillarisThunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo

Author

Yim, Soon-Ho, primary, Tabassum, Nadia, additional, Kim, Woong-Hee, additional, Cho, Haaglim, additional, Lee, Ji-Hyung, additional, Batkhuu, Galzad J., additional, Kim, Hyun Jung, additional, Oh, Won Keun, additional, Jung, Da-Woon, additional, and Williams, Darren R., additional

Published
2017
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32. Fishing for Nature’s Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products

Author

Tabassum, Nadia, Tai, Hongmei, Jung, Da-Woon, and Williams, Darren R.

Subjects
Article Subject, fungi
Abstract

Diabetes mellitus affects millions of people worldwide and significantly impacts their quality of life. Moreover, life threatening diseases, such as myocardial infarction, blindness, and renal disorders, increase the morbidity rate associated with diabetes. Various natural products from medicinal plants have shown potential as antidiabetes agents in cell-based screening systems. However, many of these potential “hits” fail in mammalian tests, due to issues such as poor pharmacokinetics and/or toxic side effects. To address this problem, the zebrafish (Danio rerio) model has been developed as a “bridge” to provide an experimentally convenient animal-based screening system to identify drug candidates that are active in vivo. In this review, we discuss the application of zebrafish to drug screening technologies for diabetes research. Specifically, the discovery of natural product-based antidiabetes compounds using zebrafish will be described. For example, it has recently been demonstrated that antidiabetic natural compounds can be identified in zebrafish using activity guided fractionation of crude plant extracts. Moreover, the development of fluorescent-tagged glucose bioprobes has allowed the screening of natural product-based modulators of glucose homeostasis in zebrafish. We hope that the discussion of these advances will illustrate the value and simplicity of establishing zebrafish-based assays for antidiabetic compounds in natural products-based laboratories.

Published
2015
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35. Isolation and Characterization of Isofraxidin 7-O-(6′-O-p-Coumaroyl)-β-glucopyranoside from Artemisia capillaris Thunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo.

Author

Yim, Soon-Ho, Tabassum, Nadia, Kim, Woong-Hee, Cho, Haaglim, Lee, Ji-Hyung, Batkhuu, Galzad J., Kim, Hyun Jung, Oh, Won Keun, Jung, Da-Woon, and Williams, Darren R.

Subjects
*HYPOPIGMENTATION, *ANIMAL experimentation, *EPITHELIAL cells, *FISHES, *MELANINS, *MOLECULAR structure, *TRANSCRIPTION factors, *PLANT extracts, *ANIMAL coloration, *HYPERPIGMENTATION, *THERAPEUTICS
Abstract

Abnormalities in skin pigmentation can produce disorders such as albinism or melasma. There is a research need to discover novel compounds that safely and effectively regulate pigmentation. To identify novel modulators of pigmentation, we attempted to purify compounds from a bioactive fraction of the Korean medicinal plant Artemisia capillaris Thunberg. The novel compound isofraxidin 7-O-(6′-O-p-coumaroyl)-β-glucopyranoside (compound 1) was isolated and its pigmentation activity was characterized in mammalian melanocytes. Compound 1 stimulated melanin accumulation and increased tyrosinase activity, which regulates melanin synthesis. Moreover, compound 1 increased the expression of tyrosinase and the key melanogenesis regulator microphthalmia-associated transcription factor (MITF) in melanocytes. Compared to the parent compound, isofraxidin, compound 1 produced greater effects on these pigmentation parameters. To validate compound 1 as a novel hyperpigmentation agent in vivo, we utilized the zebrafish vertebrate model. Zebrafish treated with compound 1 showed higher melanogenesis and increased tyrosinase activity. Compound 1 treated embryos had no developmental defects and displayed normal cardiac function, indicating that this compound enhanced pigmentation without producing toxicity. In summary, our results describe the characterization of novel natural product compound 1 and its bioactivity as a pigmentation enhancer, demonstrating its potential as a therapeutic to treat hypopigmentation disorders. [ABSTRACT FROM AUTHOR]

Published
2017
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36. Isolation of 4,5-O-Dicaffeoylquinic Acid as a Pigmentation Inhibitor Occurring in Artemisia capillaris Thunberg and Its Validation In Vivo.

Author

Tabassum, Nadia, Lee, Ji-Hyung, Yim, Soon-Ho, Batkhuu, Galzad Javzan, Jung, Da-Woon, and Williams, Darren R.

Subjects
*ANIMAL coloration, *IN vivo studies, THERAPEUTIC use of plant extracts
Abstract

There is a continual need to develop novel and effective melanogenesis inhibitors for the prevention of hyperpigmentation disorders. The plant Artemisia capillaris Thunberg (Oriental Wormwood) was screened for antipigmentation activity using murine cultured cells (B16-F10 malignant melanocytes). Activity-based fractionation using HPLC and NMR analyses identified the compound 4,5-O-dicaffeoylquinic acid as an active component in this plant. 4,5-O-Dicaffeoylquinic acid significantly reduced melanin synthesis and tyrosinase activity in a dose-dependent manner in the melanocytes. In addition, 4,5-O-dicaffeoylquinic acid treatment reduced the expression of tyrosinase-related protein-1. Significantly, we could validate the antipigmentation activity of this compound in vivo, using a zebrafish model. Moreover, 4,5-O-dicaffeoylquinic acid did not show toxicity in this animal model. Our discovery of 4,5-O-dicaffeoylquinic acid as an inhibitor of pigmentation that is active in vivo shows that this compound can be developed as an active component for formulations to treat pigmentation disorders. [ABSTRACT FROM AUTHOR]

Published
2016
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