Search

Your search keyword '"Ta-La Shi"' showing total 3 results
Start Over Author "Ta-La Shi"
3 results on '"Ta-La Shi"'

1. Implementation and evaluation of the three action teaching model with learning plan guidance in preventive medicine course

Author

Cai-Yun Chen, Ta-La Shi, Ruo-Yu Wang, Ning Li, Yi-Han Hao, Jia-Le Zhang, Ming Tang, Sha Liu, Guo-min Qin, and Wei Mi

Subjects
learning plan guidance, three action teaching model, preventive medicine, teaching design, implementation and evaluation, Psychology, BF1-990
Abstract

BackgroundToward the close of the 20th century, Chinese scholars introduced a novel pedagogical approach to education in China, distinguished by its divergence from conventional teaching methods. This instructional strategy assumes a pivotal role in imparting indispensable medical knowledge to students within a meticulously structured and all-encompassing framework.ObjectiveThe objective of this study is to assess the effectiveness of a novel teaching approach that integrates the three action teaching model with learning plan guidance within a preventive medicine course. Through this investigation, empirical evidence will be provided regarding the impact of utilizing learning guided by the three action teaching model with learning plan guidance as an innovative instructional method, thereby shedding light on its potential to enhance students’ autonomous learning in the field of preventive medicine.MethodsThe control group consisted of 48 students from Class 2 of clinical medicine in grade 2021, who were taught using the traditional classroom teaching mode. Meanwhile, Class 1 served as the experimental group comprising 47 individuals, who received instruction through the three-action teaching model with learning plan guidance. Evaluation was conducted using course tests and questionnaires, and data analysis was performed utilizing t-tests, analysis of variance, and rank sum tests in SPSS software.ResultsThe average total score of the test group (79.44 ± 10.13) was significantly higher than that of the control group (70.00 ± 13.57) (t = 3.943, p

Published
2024
Full Text
View/download PDF

2. Modulation of hepatic gene expression profiles by vitamin B1, vitamin B2, and niacin supplementation in mice exposed to acute hypoxia

Author

Jin Liu, Lingling Pu, Ya-Wen Wang, Weina Gao, Jingyu Wei, Zhonghao Xin, Ta-la Shi, and Changjiang Guo

Subjects
0301 basic medicine, B1 Vitamin, Vitamin, medicine.medical_specialty, Nutrition and Dietetics, 030102 biochemistry & molecular biology, Physiology, business.industry, Endocrinology, Diabetes and Metabolism, General Medicine, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Acute hypoxia, Endocrinology, chemistry, Physiology (medical), Internal medicine, Gene expression, Medicine, business, Niacin, Vitamin b2
Abstract

This study was aimed to observe the effects of vitamin B1, vitamin B2, and niacin supplementation on hepatic gene expression profiles in mice exposed to acute hypoxia. Thirty mice were randomly divided into normal, acute hypoxia, and acute hypoxia plus vitamin B1, vitamin B2, and niacin supplementation groups and fed corresponding diets for 2 weeks and then exposed to a simulated altitude of 6000 m for 8 h. Hepatic gene expression profiles were analyzed using a microarray technique. Several biochemical markers were also assayed. The results showed that a total of 2476 genes were expressed differentially after acute hypoxia exposure (1508 upregulated genes and 968 downregulated genes). Compared with the acute hypoxia group, there were 1382 genes differentially expressed (626 upregulated genes and 756 downregulated genes) in the acute hypoxia plus vitamin B1, vitamin B2, and niacin supplementation group. Pathway analysis indicated that carbohydrate, lipid, and amino acid metabolism, as well as electron transfer chain, were improved to some extent after vitamin B1, vitamin B2, and niacin supplementation. Supportive results were obtained from biochemical assays. Our findings suggest that the supplementation of vitamin B1, vitamin B2, and niacin is beneficial in improving nutritional metabolism partly via gene expression under acute hypoxia condition.

Published
2018
Full Text
View/download PDF

3. [Effects of MAPKs inhibitors on GSH metabolic enzymes in rat hepatocytes]

Author

Wei-Na, Gao, Ling-Ling, Pu, Jing-Yu, Wei, Zhong-Hao, Xin, Ya-Wen, Wang, Ta-la, Shi, Tian, Li, and Chang-Jiang, Guo

Subjects
Hepatocytes, JNK Mitogen-Activated Protein Kinases, Animals, Enzyme Inhibitors, Mitogen-Activated Protein Kinases, Glutathione, Cells, Cultured, Rats
Abstract

To investigate the effects of mitogen-activated protein kinases (MAPKs) inhibitors on glutathione (GSH) metabolism, and to explore the pathway related to GSH metabolism.BRL rat hepatocytes were treated by c-Jun NH2-terminal kinase (JNK),p38, and extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitors:SP600125, SB203580 and PD98659, respectively, for 24 h. MTT method was used to measure hepatocytes viability. The content of GSH was determined by high performance liquid chromatography. The protein expressions of JNK and phosphorylated JNK (p-JNK) was tested by Luminex method. Activities of GSH metabolic enzymes were detected by commercial kits.Hepatocytes vitality was inhibited when the concentrations of SP600125, SB203580 and PD98659 were higher than 10JNK MAPK pathway takes part in the GSH metabolism in hepatocytes.

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results