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Your search keyword '"TUMMINELLO, Francesca Maria"' showing total 22 results
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22 results on '"TUMMINELLO, Francesca Maria"'

4. Flow cytometric DNA analysis and lysosomal cathepsins B and L in locally advanced laryngeal cancer: relationship with clinicopathologic parameters and prognostic significance

Author

Russo, Antonio, Bazan, Viviana, Gebbia, Nicola, Pizzolanti, Giuseppe, Tumminello, Francesca Maria, Dardanoni, Gabriella, Ingria, Federico, Restivo, Salvatore, Tomasino, Rosa Maria, and Leto, Gaetano

Subjects
Squamous cell carcinoma -- Prognosis, Laryngeal cancer -- Prognosis, Flow cytometry -- Diagnostic use, Health
Published
1995

5. Effects of extra virgin olive oil phenols on HL60 cell lines sensitive and resistant to anthracyclines

Author

CRESCIMANNO, Marilena, SEPPORTA, Maria Vittoria, TRIPOLI, Elisa, FLANDINA, Carla, GIAMMANCO, Marco, TUMMINELLO, Francesca Maria, DI MAJO, Danila, Tolomeo, M, LA GUARDIA, Maurizio, LETO, Gaetano, Crescimanno, M, Sepporta, MV, Tripoli, E, Flandina, C, Giammanco, M, Tumminello, FM, Di Majo, D, Tolomeo, M, La Guardia, M, and Leto, G

Subjects
lcsh:Biology (General), Phenols, apoptosis, differentiation, human cell lines, Biochemistry (medical), Settore BIO/14 - Farmacologia, Plant Science, Phenols, apoptosis, differentiation, human cancer cell lines, Settore BIO/09 - Fisiologia, lcsh:QH301-705.5, General Biochemistry, Genetics and Molecular Biology
Abstract

The aim of our study was to evaluate the capability of a crude extract of phenols from extra virgin olive oil of Moraiolo cultivar to induce apoptosis and/or differentiation in sensitive and resistant HL60 cell lines to anticancer drugs (Typical Multidrug Resistance). Our data highlight that the crude extract is able to induce apoptosis on both sensitive and resistant cells, whereas the exposure to a number of anticancer drugs does not induce apoptosis in resistant cells. In differentiation experiments we investigated the capability of crude extract of phenols to induce the expression of CD11 granulocytic or CD14 monocytic cell surface antigen in sensitive and resistant HL60 cell lines. At IC50 dose level (17 µg/ml and 32 µg/ml respectively for sensitive and resistant cell lines), the crude extract induced differentiation associated with the expression of CD14 monocytic cell surface antigen either in sensitive or resistant cell lines but not that of CD11 granulocityc cell surface antigen. Further investigations are in progress to better clarify the mechanism by which olive oil phenols induce differentiation differentiation on this cell line.

Published
2009

7. Cytotoxic effects of polyphenols from waste-water of extra virgin olive oil on human HL60 and K562 cell lines

Author

SEPPORTA, Maria Vittoria, LETO, Gaetano, FLANDINA, Carla, TUMMINELLO, Francesca Maria, LA GUARDIA, Maurizio, GIAMMANCO, Marco, DI MAJO, Danila, CRESCIMANNO, Marilena, Tolomeo, M, Sepporta, MV, Leto, G, Flandina, C, Tumminello, FM, La Guardia, M, Giammanco, M, Di Majo, D, Tolomeo, M, and Crescimanno, M

Subjects
Polyphenols, HL60, K562, apoptosis, Settore BIO/14 - Farmacologia, Settore BIO/09 - Fisiologia
Published
2009

9. Sexual abuse and maltratment on child: protocols, cooperation strategies, daphne II - V.eR.S.O. (Violenza e reti sanitarie operative) Project- our experience

Author

ARGO, Antonina, SALERNO A, IPPOLITO C, Bono, Giuseppe, COLLINE, Rosanna, CAPPELLO, Rosaria, MURGO, Valentina, ZERBO, Stefania, TUMMINELLO, Francesca Maria, PROCACCIANTI, Paolo, ARGO A, SALERNO A, IPPOLITO C, BONO G, COLLINE R, CAPPELLO R, MURGO V, ZERBO S, TUMMINELLO FM, and PROCACCIANTI P

Subjects
Sexual abuse, maltratment on child, daphne II - V.eR.S.O
Published
2008

13. Induction of differentiation by phenols crude extract of extravirgin olive oil on tumor cell lines sensitive and resistatnt to antitumor agents

Author

CRESCIMANNO, Marilena, FLANDINA, Carla, LETO, Gaetano, TUMMINELLO, Francesca Maria, TRIPOLI, Elisa, GIAMMANCO, Marco, DI CRISTINA, Antonietta, GRIMAUDO, Stefania, Boscarino, B, Dervili, M, Tolomeo, M., Crescimanno, M, Boscarino, B, Flandina, C, Leto, G, Tumminello, FM, Tripoli, E, Giammanco, M, Dervili, M, Di Cristina,A, Grimaudo, S, and Tolomeo, M

Subjects
Phenols, drug resistance, extravirgin olive oil
Published
2006

21. The Role of Histamine in Doxorubicin and Teniposide-Induced Cardiotoxicity in Dog and Mouse

Author

Gebbia, Nicola, Flandina, Carla, Leto, Gaetano, Tumminello, Francesca Maria, Sanguedolce, Rosario, Candiloro, Vincenza, Gagliano, Mauro, and Rausa, Luciano

Abstract

In previous studies we reported that teniposide (VM26) induced acute cardiac effects in dogs seem to be related to a release of histamine and that a prior treatment with chlorpheniramine, an H, histamine blocker, prevents the onset of this phenomenon. Since histamine and other vasoactive substances also seem to be involved in doxorubicin (DXR)-induced acute cardiac effects, experiments were undertaken in the aim to prevent, as in the case of VM26, the onset of this phenomenon by administering chlorpheniramine. Since DXR-induced chronic cardiomyopathy also seems to be related to the same mechanisms involved in the onset of acute cardiac effects induced by this drug, additional studies were carried out to investigate whether a long-term treatment with VM26 could induce in mouse alterations of cardiac morphology similar to those of DXR. In addition, because the mouse is known to be extremely insensitive to histamine, further studies were performed to investigate whether DXR or VM26 administration could induce in this animal model a massive histamine release and whether a long-term treatment with high doses of histamine could elicit, similarly to DXR, alterations in cardiac morphology. The results of our experiments demonstrated that DXR (1.5 mg/kg i.v.) caused in the dog a massive histamine release and a marked impairment of cardiac inotropism. As previously described for VM26, prior treatments with chlorpheniramine completely prevented this phenomenon. Furthermore, DXR administration, at a dose level able to induce cardiac damage in the mouse (2.5 mg/kg i.v.), or that of VM26 (2 mg/kg i.v.) failed to induce a massive histamine release. In addition, long-term treatment with VM26 (2 mg/kg i.v.) or high doses of histamine (100 mg/kg i.v.), unlike DXR, did not elicit in this animal alterations of cardiac morphology. Finally, chlorpheniramine (0.15 or 0.45 mg/kg i.v.) did not prevent the onset of chronic cardiomyopathy induced by DXR in mouse. In conclusion, our results show that the role of histamine in the onset of DXR-induced chronic cardiomyopathy, at least in mouse, remains questionable and suggest that this animal, because of its high natural resistance to histamine, is not a suitable experimental model to investigate the cardiovascular pharmacology of drug-induced histamine release.

Published
1987
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22. Effects of zoledronic acid on proteinase plasma levels in patients with bone metastases.

Author

Leto G, Badalamenti G, Arcara C, Crescimanno M, Flandina C, Tumminello FM, Incorvaia L, Gebbia N, and Fulfaro F

Subjects
Aged, Aged, 80 and over, Bone Density Conservation Agents therapeutic use, Bone Neoplasms secondary, Breast Neoplasms enzymology, Breast Neoplasms pathology, Cathepsin B blood, Diphosphonates therapeutic use, Female, Humans, Imidazoles therapeutic use, Male, Matrix Metalloproteinase 2 blood, Matrix Metalloproteinase 9 blood, Middle Aged, Prostatic Neoplasms enzymology, Prostatic Neoplasms pathology, Urokinase-Type Plasminogen Activator blood, Zoledronic Acid, Bone Density Conservation Agents pharmacology, Bone Neoplasms drug therapy, Bone Neoplasms enzymology, Diphosphonates pharmacology, Imidazoles pharmacology
Abstract

Background: The effects of the bisphosphonate derivative zoledronic acid (ZA) on the circulating levels of matrix metalloproteinase-2 (MMP-2), matrix metallo-proteinases-9 (MMP-9), cathepsin B (Cath B) and urokinase-type plasminogen activator (uPA) in patients with bone metastasis (BMTS) and the possible correlation with the symptomatic response induced by this drug in these patients were evaluated., Patients and Methods: Proteinase levels were determined by enzyme-linked immunosorbent assay (ELISA) in the plasma of 30 patients with painful bone metastases from breast or prostate cancer undergoing multiple treatment with ZA (4 mg i.v., every 4 weeks). Healthy subjects (HS) of both genders (12 female and 30 male) served as the control group. The symptomatic response to ZA was assessed by the visual analog scale score (VAS)., Results: The median MMP-2 and MMP-9 pretreatment levels were more elevated in BMTS as compared to HS (p < or = 0.0001). Conversely, uPA levels were lower in BMTS p = 0.0033; no significant difference was observed for Cath B. ZA administration was associated with a symptomatic response (VAS score < or =4) in 25/30patients (83.3%) (p < 0.0001). This phenomenon paralleled a decrease of Cath B and MMP-2 plasma concentrations from baseline values on week 12 (p = 0.05). A similar trend, although not statistically significant, was also noted for MMP-9 and uPA. However, no direct relationship was observed between the analgesic effect induced by ZA and changes in the circulating levels of these enzymes., Conclusion: These data show that ZA administration may provide relief from bone pain in patients with diffuse skeletal metastases and confirm a possible implication of cysteine proteinases and matrix metalloproteinases in bone metastasis formation, but not in the pathogenesis of metastatic bone pain.

Published
2006

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