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3. Relationship of Fatigue, Pain Interference, and Physical Disability in Children Newly Diagnosed With Juvenile Idiopathic Arthritis

Author

Choong, Naomi, Batthish, Michelle, Berard, Roberta A., Chédeville, Gaëlle, Feldman, Brian M., Houghton, Kristin M., Huber, Adam M., James, Sarah, Proulx‐Gauthier, Jean‐Philippe, Rumsey, Dax G., Schmeling, Heinrike, Toupin‐April, Karine, Guzman, Jaime, Cabral, David A., Chédeville, Gaëlle, Duffy, Ciarán M., Gerhold, Kerstin, Guzman, Jaime, Hiraki, Linda, Huber, Adam M., Schmeling, Heinrike, Shiff, Natalie J., Tucker, Lori B., Barsalou, Julie, Basodan, Daniah, Batthish, Michelle, Berard, Roberta A., Blanchette, Nicholas, Boire, Gilles, Bolaria, Roxana, Bruns, Alessandra, Cabral, David, Campillo, Sarah, Cellucci, Tania, Chan, Mercedes, Chédeville, Gaëlle, Chhabra, Amieleena, Couture, Julie, Dancey, Paul, De Bruycker, Jean‐Jacques, Demirkaya, Erkan, Dhalla, Muhammed, Duffy, Ciarán M., El Tal, Talal, Gerschman, Tommy, Guzman, Jaime, Heale, Liane, Herrington, Julie, Houghton, Kristin M., Huber, Adan M., Human, Andrea, Johnson, Nicole, Jurencak, Roman, Lang, Bianca, LeBlanc, Claire, Lim, Lilian, Lim, Lily S. H., Luca, Nadia, McColl, Jeanine, McGrath, Tara, McMillan, Tamara, McPherson, Megan, Miettunen, Paivi, Morishita, Kimberly, Ng, Honyan, Park, Jonathan, Proulx‐Gauthier, Jean‐Philippe, Roth, Johannes, Rozenblyum, Evelyn, Rumsey, Dax G., Schmeling, Heinrike, Scuccimarri, Rosie, Soon, Gordon, Stevenson, Rebeka, Stringer, Elizabeth, Tam, Herman, Tucker, Lori B., Twilt, Marinka, Verstegen, Ruud H. J., and Duffy, Karen Watanabe

Abstract

Our objectives were to quantify the relationships among fatigue, pain interference, and physical disability in children with juvenile idiopathic arthritis (JIA) and to test whether fatigue mediates the relationship between pain interference and physical disability in JIA. Patients enrolled within three months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry between February 2017 and May 2023 were included. Their parents completed the Patient‐Reported Outcomes Measurement Information System fatigue and pain interference short proxy questionnaires and the Childhood Health Assessment Questionnaire disability index at registry enrollment. Associations were assessed using Pearson correlations and multiple linear regression. Structural equation modeling (SEM) was used to test if fatigue mediates the relationship between pain interference and physical disability. Among 855 patients (61.4% female, 44.1% with oligoarthritis), most reported fatigue and pain interference scores similar to those in the reference population, but 15.6% reported severe fatigue and 7.3% reported severe pain interference, with wide variation across JIA categories. Fatigue was strongly correlated with pain interference (r = 0.72, P< 0.001) and with physical disability (r= 0.60, P< 0.001). Pain interference (β = 0.027, P< 0.001) and fatigue (β = 0.013, P< 0.001) were both associated with physical disability after controlling for each other and potential confounders. SEM supported our hypothesis that fatigue partially mediates the relationship between pain interference and physical disability. Our findings suggest both fatigue and pain interference are independently associated with physical disability in children newly diagnosed with JIA, and the effect of pain interference may be partly mediated by fatigue.

Published
2024
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4. Higher concentrations of vitamin D in Canadian children with juvenile idiopathic arthritis compared to healthy controls are associated with more frequent use of vitamin D supplements and season of birth

Author

Finch, Sarah L., Rosenberg, Alan M., Kusalik, Anthony J., Maleki, Farhad, Rezaei, Elham, Baxter-Jones, Adam, Benseler, Susanne, Boire, Gilles, Cabral, David, Campillo, Sarah, Chédeville, Gaëlle, Chetaille, Anne-Laure, Dancey, Paul, Duffy, Ciaran, Duffy, Karen Watanabe, Guzman, Jaime, Houghton, Kristin, Huber, Adam M., Jurencak, Roman, Lang, Bianca, Laxer, Ron M., Morishita, Kimberly, Oen, Kiem G., Petty, Ross E., Ramsey, Suzanne E., Roth, Johannes, Schneider, Rayfel, Scuccimarri, Rosie, Stringer, Elizabeth, Tse, Shirley M.L., Tucker, Lori B., Turvey, Stuart E., Szafron, Michael, Whiting, Susan, Yeung, Rae SM, and Vatanparast, Hassan

Published
2021
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5. Parent‐Reported Medication Side Effects and Their Impact on Health‐Related Quality of Life in Children With Juvenile Idiopathic Arthritis

Author

Chédeville, Gaëlle, McGuire, Katherine, Cabral, David A., Shiff, Natalie J., Rumsey, Dax G., Proulx‐Gauthier, Jean‐Philippe, Schmeling, Heinrike, Berard, Roberta A., Batthish, Michelle, Soon, Gordon, Gerhold, Kerstin, Gerschman, Tommy, Bruns, Alessandra, Duffy, Ciaran M., Tucker, Lori B., and Guzman, Jaime

Published
2022
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10. A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: results from ReACCh-Out and the CAPRI registry

Author

Nguyen, Kelly, primary, Barsalou, Julie, additional, Basodan, Daniah, additional, Batthish, Michelle, additional, Benseler, Susanne M, additional, Berard, Roberta A, additional, Blanchette, Nicholas, additional, Boire, Gilles, additional, Bolaria, Roxana, additional, Bruns, Alessandra, additional, Cabral, David A, additional, Cameron, Bonnie, additional, Campillo, Sarah, additional, Cellucci, Tania, additional, Chan, Mercedes, additional, Chédeville, Gaëlle, additional, Chetaille, Anne-Laure, additional, Chhabra, Amieleena, additional, Couture, Julie, additional, Dancey, Paul, additional, De Bruycker, Jean-Jacques, additional, Demirkaya, Erkan, additional, Dhalla, Muhammed, additional, Duffy, Ciarán M, additional, Feldman, Brian M, additional, Feldman, Debbie E, additional, Gerschman, Tommy, additional, Haddad, Elie, additional, Heale, Liane, additional, Herrington, Julie, additional, Houghton, Kristin, additional, Huber, Adam M, additional, Human, Andrea, additional, Johnson, Nicole, additional, Jurencak, Roman, additional, Lang, Bianca, additional, Larché, Maggie, additional, Laxer, Ronald M, additional, LeBlanc, Claire M, additional, Lee, Jennifer J Y, additional, Levy, Deborah M, additional, Lim, Lillian, additional, Lim, Lily S H, additional, Luca, Nadia, additional, McGrath, Tara, additional, McMillan, Tamara, additional, Miettunen, Paivi M, additional, Morishita, Kimberly A, additional, Ng, Hon Yan, additional, Oen, Kiem, additional, Park, Jonathan, additional, Petty, Ross E, additional, Proulx-Gauthier, Jean-Philippe, additional, Ramsey, Suzanne, additional, Roth, Johannes, additional, Rosenberg, Alan M, additional, Rozenblyum, Evelyn, additional, Rumsey, Dax G, additional, Schmeling, Heinrike, additional, Schneider, Rayfel, additional, Scuccimarri, Rosie, additional, Shiff, Natalie J, additional, Silverman, Earl, additional, Soon, Gordon, additional, Spiegel, Lynn, additional, Stringer, Elizabeth, additional, Tam, Herman, additional, Tse, Shirley M, additional, Tucker, Lori B, additional, Turvey, Stuart, additional, Twilt, Marinka, additional, Duffy, Karen Watanabe, additional, Yeung, Rae S M, additional, and Guzman, Jaime, additional

Published
2023
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12. Impact of employment and income support interventions on the health of young adults with episodic disability: Findings from a systematic review.

Author

Jetha, Arif, Navaratnerajah, Lahmea, Kondratowski, Sebastian, Parmassar, Meagan, Tucker, Lori B., and Gignac, Monique A. M.

Abstract

The article focuses on the challenges faced by young adults with episodic disabilities in employment due to unpredictable health fluctuations, including prevalent physical and mental health conditions such as juvenile arthritis and anxiety, which can disrupt work and quality of life. It discusses the stress and difficulties in finding and sustaining employment, navigating fluctuating symptoms, and communicating support needs.

Published
2024
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15. Trajectories of pain severity in juvenile idiopathic arthritis: results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort

Author

Shiff, Natalie J., Tupper, Susan, Oen, Kiem, Guzman, Jaime, Lim, Hyun, Lee, Chel Hee, Bryce, Rhonda, Huber, Adam M., Boire, Gilles, Dancey, Paul, Feldman, Brian, Laxer, Ronald, Miettunen, Paivi, Schmeling, Heinrike, Watanabe Duffy, Karen, Levy, Deborah M., Turvey, Stuart, Bolaria, Roxana, Bruns, Alessandra, Cabral, David A., Campillo, Sarah, Chédeville, Gaëlle, Feldman, Debbie Ehrmann, Haddad, Elie, Houghton, Kristin, Johnson, Nicole, Jurencak, Roman, Lang, Bianca, Larche, Maggie, Morishita, Kimberly, Ramsey, Suzanne, Roth, Johannes, Schneider, Rayfel, Scuccimarri, Rosie, Spiegel, Lynn, Stringer, Elizabeth, Tse, Shirley M., Yeung, Rae, Duffy, Ciarán M., and Tucker, Lori B.

Published
2018
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16. Validation of the parent global assessment as a health-related quality of life measure in juvenile idiopathic arthritis: results from ReACCh-Out

Author

Oen, Kiem, Toupin-April, Karine, Feldman, Brian M, Berard, Roberta A, Duffy, Ciẚran M, Tucker, Lori B, Tian, Jiahao, Rumsey, Dax G, and Guzman, Jaime

Subjects
Rheumatology, Pharmacology (medical), Clinical Science
Abstract

Objectives To (i) validate the JIA parent global assessment (parent global) as a health-related quality of life (HRQoL) instrument; (ii) evaluate measurement properties of accepted HRQoL measures relative to those of the parent global; and (iii) assess causal pathways determining parent global scores. Methods Data from the Research in Arthritis in Canadian Children emphasizing outcomes (ReACCh-Out) cohort were used. Measurement properties were assessed in 344 patients at enrolment and 6 months later. Causal pathways were tested by structural equation modelling to understand root causes and mediators leading to parent global scores. Results Construct validity was supported by Spearman correlations of 0.53–0.70 for the parent global with the Juvenile Arthritis Quality of Life Questionnaire, Quality of My Life health scale (HRQoML), Pediatric Quality of Life Inventory (PedsQL)-Parent, and Child Health Questionnaire (CHQ)-Physical. Exceptions were PedsQL-Child (0.44) and CHQ-Psychosocial (0.31). Correlations were lower (0.14–0.49) with disease activity measures (physician global assessment of disease activity, active joint count, ESR). Responsiveness of the parent global to improvement according to parent ratings (0.51) was acceptable and within the range (0.32–0.71) of that of other measures. Reliability estimates and measurement errors for all measures were unsatisfactory, likely due to the prolonged time between assessments. Causal pathways for the parent global matched those previously reported for HRQoML. Conclusions Our results offer support for the parent global as a valid measure of HRQoL for JIA. If confirmed, existing studies using the parent global may be re-interpreted, enhancing our knowledge of HRQoL in children with JIA.

Published
2022

19. The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort

Author

Guzman, Jaime, Oen, Kiem, Huber, Adam M, Watanabe Duffy, Karen, Boire, Gilles, Shiff, Natalie, Berard, Roberta A, Levy, Deborah M, Stringer, Elizabeth, Scuccimarri, Rosie, Morishita, Kimberly, Johnson, Nicole, Cabral, David A, Rosenberg, Alan M, Larché, Maggie, Dancey, Paul, Petty, Ross E, Laxer, Ronald M, Silverman, Earl, Miettunen, Paivi, Chetaille, Anne-Laure, Haddad, Elie, Houghton, Kristin, Spiegel, Lynn, Turvey, Stuart E, Schmeling, Heinrike, Lang, Bianca, Ellsworth, Janet, Ramsey, Suzanne E, Bruns, Alessandra, Roth, Johannes, Campillo, Sarah, Benseler, Susanne, Chédeville, Gaëlle, Schneider, Rayfel, Tse, Shirley M L, Bolaria, Roxana, Gross, Katherine, Feldman, Brian, Feldman, Debbie, Cameron, Bonnie, Jurencak, Roman, Dorval, Jean, LeBlanc, Claire, St. Cyr, Claire, Gibbon, Michele, Yeung, Rae S M, Duffy, Ciarán M, and Tucker, Lori B

Published
2016
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20. Comparing Canadian paediatric rheumatology practice to the 2019 ACR Juvenile Idiopathic Arthritis guidelines: results from the CAPRI Registry.

Author

Park, Jonathan, Batthish, Michelle, Berard, Roberta A, Chédeville, Gaëlle, Proulx-Gauthier, Jean-Philippe, Rumsey, Dax G, Tucker, Lori B, Wong, Stephanie, Guzman, Jaime, and Investigators, for the CAPRI Registry

Subjects
BIOTHERAPY, RHEUMATOLOGY, NONSTEROIDAL anti-inflammatory agents, JUVENILE idiopathic arthritis, PEDIATRICS, ACQUISITION of data, MEDICAL protocols, COMPARATIVE studies, SURVEYS, RHEUMATOLOGISTS, METHOTREXATE, ANTIRHEUMATIC agents, MEDICAL records, KAPLAN-Meier estimator, DESCRIPTIVE statistics, RESEARCH funding, SACROILIITIS, LONGITUDINAL method
Abstract

Objective To identify differences between baseline Canadian JIA practices and the 2019 ACR guidelines for JIA. Methods Canadian paediatric rheumatologists were surveyed for their opinions on reasonable a priori target adherence rates for JIA guideline recommendations. Prospectively collected data for 266 newly diagnosed children from 2017 to 2019 were analysed to calculate observed adherence rates. Kaplan–Meier survival curves were used to estimate the cumulative incidence of starting synthetic or biologic DMARDs (sDMARD or bDMARD, respectively) for different patient groups. Results A total of 25/61 (41%) eligible physicians answered the survey. Most survey respondents (64%) felt that adherence targets should vary depending on the strength of the recommendation and quality of evidence, from a mean of 84% for strong recommendations with high-quality evidence to 29% for conditional recommendations with very low-quality evidence. Data showed 13/19 (68%) recommendations would have met proposed targets and 10/19 (53%) had ≥80% observed adherence. Exceptions were the use of subcutaneous vs oral MTX (53%) and infrequent treatment escalation from NSAIDs to bDMARDs in patients with sacroiliitis (31%) or enthesitis (0%). By 12 weeks, 95% of patients with polyarthritis received sDMARDs, 38% of patients with systemic JIA received bDMARDs and 22% of patients with sacroiliitis received bDMARDs. Conclusion Canadian paediatric rheumatology practices were in line with many 2019 JIA guideline recommendations before their publication, except for frequent use of oral MTX and infrequent direct escalation from NSAIDs to bDMARDs in sacroiliitis and enthesitis. [ABSTRACT FROM AUTHOR]

Published
2023
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21. The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort

Author

Guzman, Jaime, Oen, Kiem, Tucker, Lori B, Huber, Adam M, Shiff, Natalie, Boire, Gilles, Scuccimarri, Rosie, Berard, Roberta, Tse, Shirley M L, Morishita, Kimberly, Stringer, Elizabeth, Johnson, Nicole, Levy, Deborah M, Duffy, Karen Watanabe, Cabral, David A, Rosenberg, Alan M, Larché, Maggie, Dancey, Paul, Petty, Ross E, Laxer, Ronald M, Silverman, Earl, Miettunen, Paivi, Chetaille, Anne-Laure, Haddad, Elie, Houghton, Kristin, Spiegel, Lynn, Turvey, Stuart E, Schmeling, Heinrike, Lang, Bianca, Ellsworth, Janet, Ramsey, Suzanne, Bruns, Alessandra, Campillo, Sarah, Benseler, Susanne, Chédeville, Gaëlle, Schneider, Rayfel, Yeung, Rae, Duffy, Ciarán M, Bolaria, Roxana, Gross, Katherine, Feldman, Brian, Feldman, Debbie, Cameron, Bonnie, Jurencak, Roman, Roth, Johannes, Dorval, Jean, LeBlanc, Claire, and St. Cyr, Claire

Published
2015
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22. Validation of the parent global assessment as a health-related quality of life measure in juvenile idiopathic arthritis: results from ReACCh-Out.

Author

Oen, Kiem, Toupin-April, Karine, Feldman, Brian M, Berard, Roberta A, Duffy, Ciẚran M, Tucker, Lori B, Tian, Jiahao, Rumsey, Dax G, Guzman, Jaime, and investigators, ReACCh-Out

Subjects
RESEARCH methodology evaluation, RESEARCH methodology, JUVENILE idiopathic arthritis, QUALITY of life
Abstract

Objectives To (i) validate the JIA parent global assessment (parent global) as a health-related quality of life (HRQoL) instrument; (ii) evaluate measurement properties of accepted HRQoL measures relative to those of the parent global; and (iii) assess causal pathways determining parent global scores. Methods Data from the Research in Arthritis in Canadian Children emphasizing outcomes (ReACCh-Out) cohort were used. Measurement properties were assessed in 344 patients at enrolment and 6 months later. Causal pathways were tested by structural equation modelling to understand root causes and mediators leading to parent global scores. Results Construct validity was supported by Spearman correlations of 0.53–0.70 for the parent global with the Juvenile Arthritis Quality of Life Questionnaire, Quality of My Life health scale (HRQoML), Pediatric Quality of Life Inventory (PedsQL)-Parent, and Child Health Questionnaire (CHQ)-Physical. Exceptions were PedsQL-Child (0.44) and CHQ-Psychosocial (0.31). Correlations were lower (0.14–0.49) with disease activity measures (physician global assessment of disease activity, active joint count, ESR). Responsiveness of the parent global to improvement according to parent ratings (0.51) was acceptable and within the range (0.32–0.71) of that of other measures. Reliability estimates and measurement errors for all measures were unsatisfactory, likely due to the prolonged time between assessments. Causal pathways for the parent global matched those previously reported for HRQoML. Conclusions Our results offer support for the parent global as a valid measure of HRQoL for JIA. If confirmed, existing studies using the parent global may be re-interpreted, enhancing our knowledge of HRQoL in children with JIA. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Children with systemic autoinflammatory diseases have multiple, mixed ethnicities that reflect regional ethnic diversity

Author

Tucker, Lori B., primary, Niemietz, Iwona, additional, Mangat, Preet, additional, Belen, Maria, additional, Tekano, Jenny, additional, Cabral, David A., additional, Guzman, Jaime, additional, Houghton, Kristin M., additional, Morishita, Kimberly A., additional, Chan, Mercedes O., additional, Human, Andrea, additional, Sundqvist, Martina, additional, and Brown, Kelly L., additional

Published
2021
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26. Additional file 1 of Clinical and psychosocial stress factors are associated with decline in physical activity over time in children with juvenile idiopathic arthritis

Author

Heale, Liane D., Houghton, Kristin M., Rezaei, Elham, Baxter-Jones, Adam D. G., Tupper, Susan M., Muhajarine, Nazeem, Benseler, Susanne M., Boire, Gilles, Cabral, David A., Campillo, Sarah, Chédeville, Gaëlle, Chetaille, Anne-Laure, Dancey, Paul, Duffy, Ciaran, Duffy, Karen Watanabe, Ellsworth, Janet, Guzman, Jaime, Huber, Adam M., Jurencak, Roman, Lang, Bianca, Laxer, Ronald M., Morishita, Kimberly, Oen, Kiem G., Petty, Ross E., Ramsey, Suzanne E., Roth, Johannes, Schneider, Rayfel, Scuccimarri, Rosie, Spiegel, Lynn, Stringer, Elizabeth, Tse, Shirley M. L., Tucker, Lori B., Turvey, Stuart E., Yeung, Rae S. M., and Rosenberg, Alan M.

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2021
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27. Predicting Which Children with Juvenile Idiopathic Arthritis Will Not Attain Early Remission with Conventional Treatment: Results from the ReACCh-Out Cohort

Author

Guzman, Jaime, Henrey, Andrew, Loughin, Thomas, Berard, Roberta A., Shiff, Natalie J., Jurencak, Roman, Huber, Adam M., Oen, Kiem, Gerhold, Kerstin, Feldman, Brian M., Scuccimarri, Rosie, Houghton, Kristin, Chédeville, Gaëlle, Morishita, Kimberly, Lang, Bianca, Dancey, Paul, Rosenberg, Alan M., Barsalou, Julie, Bruns, Alessandra, Duffy, Karen Watanabe, Benseler, Susanne, Duffy, Ciaran M., Tucker, Lori B., Bolaria, Roxana, Gross, Katherine, Turvey, Stuart E., Cabral, David, Petty, Ross, and Ellsworth, Janet

Subjects
Male, Pediatrics, medicine.medical_specialty, Adolescent, Immunology, Arthritis, Early remission, Logistic regression, Severity of Illness Index, Decile, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, medicine, Humans, Immunology and Allergy, Juvenile, Treatment Failure, 030212 general & internal medicine, Child, Risk stratification, 030203 arthritis & rheumatology, Biological Products, business.industry, Remission Induction, Conventional treatment, Juvenile idiopathic arthritis, Prognosis, medicine.disease, Arthritis, Juvenile, Logistic Models, Treatment Outcome, Antirheumatic Agents, Child, Preschool, Cohort, Cohort studies, Female, Prediction, business, Cohort study
Abstract

Objective.To estimate the probability of early remission with conventional treatment for each child with juvenile idiopathic arthritis (JIA). Children with a low chance of remission may be candidates for initial treatment with biologics or triple disease-modifying antirheumatic drugs (DMARD).Methods.We used data from 1074 subjects in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort. The predicted outcome was clinically inactive disease for ≥ 6 months starting within 1 year of JIA diagnosis in patients who did not receive early biologic agents or triple DMARD. Models were developed in 200 random splits of 75% of the cohort and tested on the remaining 25% of subjects, calculating expected and observed frequencies of remission and c-index values.Results.Our best Cox logistic model combining 18 clinical variables a median of 2 days after diagnosis had a c-index of 0.69 (95% CI 0.67–0.71), better than using JIA category alone (0.59, 95% CI 0.56–0.63). Children in the lowest probability decile had a 20% chance of remission and 21% attained remission; children in the highest decile had a 69% chance of remission and 73% attained remission. Compared to 5% of subjects identified by JIA category alone, the model identified 14% of subjects as low chance of remission (probability < 0.25), of whom 77% failed to attain remission.Conclusion.Although the model did not meet our a priori performance threshold (c-index > 0.70), it identified 3 times more subjects with low chance of remission than did JIA category alone, and it may serve as a benchmark for assessing value added by future laboratory/imaging biomarkers.

Published
2019
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37. CONTRIBUTORS

Author

Albani, Salvatore, primary, Alsaeid, Khaled, additional, Athreya, Balu H., additional, Avčin, Tadej, additional, Babyn, Paul, additional, Bagga, Arvind, additional, Barron, Karyl S., additional, Benseler, Susanne, additional, Brogan, Paul, additional, Brunner, Hermine I., additional, Burgos-Vargas, Rubén, additional, Buyon, Jill P., additional, Cabral, David A., additional, Cassidy, James T., additional, Cimaz, Rolando, additional, Colbert, Robert A., additional, Davidson, Iris L., additional, De Benedetti, Fabrizio, additional, Dillon, Michael J., additional, Doria, Andrea Schwarz, additional, Dressler, Frank, additional, Duffy, Ciarán M., additional, Eddy, Allison A., additional, Falcini, Fernanda, additional, Feldman, Brian M., additional, Ferguson, Polly J., additional, Fuhlbrigge, Robert C., additional, Gattorno, Marco, additional, Giannini, Edward H., additional, Glass, David N., additional, Grom, Alexei A., additional, Houghton, Kristin, additional, Huppertz, Hans-Iko, additional, Ilowite, Norman T., additional, Kastner, Daniel L., additional, Kuchta, Gay, additional, Kuis, Wietse, additional, Laxer, Ronald M., additional, LeBlanc, Claire, additional, Lindsley, Carol B., additional, Martini, Alberto, additional, Nigrovic, Peter A., additional, O'Neil, Kathleen M., additional, Oen, Kiem G., additional, Özen, Seza, additional, Pepmueller, Peri Hickman, additional, Prakken, Berent J., additional, Rapoff, Michael A., additional, Rider, Lisa G., additional, Rosé, Carlos D., additional, Rosenbaum, James T., additional, Rosenberg, Alan M., additional, Schneider, Rayfel, additional, Sherry, David D., additional, Silverman, Earl D., additional, Sundel, Robert P., additional, Thompson, Susan D., additional, Tucker, Lori B., additional, van Montfrans, Joris, additional, Vázquez-Mellado, Janitzia, additional, Wenkert, Deborah, additional, Wouters, Carine H., additional, Wulffraat, Nico, additional, and Zulian, Francesco, additional

Published
2011
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38. A Comparison of International League of Associations for Rheumatology and Pediatric Rheumatology International Trials Organization Classification Systems for Juvenile Idiopathic Arthritis Among Children in a Canadian Arthritis Cohort.

Author

Lee, Jennifer J. Y., Eng, Simon W. M., Guzman, Jaime, Duffy, Ciáran M., Tucker, Lori B., Oen, Kiem, Yeung, Rae S. M., and Feldman, Brian M.

Subjects
RHEUMATOLOGY, JUVENILE idiopathic arthritis, COMPARATIVE studies, DESCRIPTIVE statistics, INTERNATIONAL agencies, LONGITUDINAL method
Abstract

Objective: The aim of the Paediatric Rheumatology International Trials Organisation (PRINTO) juvenile idiopathic arthritis (JIA) classification criteria, which is still in development, is to identify homogeneous groups of JIA patients. This study was undertaken to compare International League of Associations for Rheumatology (ILAR) JIA classification criteria and PRINTO JIA classification criteria using data from the ReACCh‐Out (Research in Arthritis in Canadian Children, Emphasizing Outcomes) cohort. Methods: We used clinicobiologic data recorded within 7 months of diagnosis to assign a diagnosis of JIA and identify subcategories of JIA among 1,228 patients according to the 2 JIA classification systems. We compared the proportions of patients classified and the alignment of classification categories with clinicobiologic subtypes and adult arthritis types. Results: The PRINTO criteria classified 244 patients (19.9%) as having early‐onset antinuclear antibody–positive JIA, 157 (12.8%) as having enthesitis/spondylitis–related JIA, 38 (3.1%) as having systemic JIA, and 10 (0.8%) as having rheumatoid factor–positive JIA. A total of 12% of patients were unclassifiable using the ILAR criteria, while 63.3% were unclassifiable using the PRINTO criteria (777 with other JIA and 2 with unclassified JIA). In sensitivity analyses, >50% of patients remained unclassifiable using the PRINTO criteria. Compared to the PRINTO criteria, ILAR JIA categories aligned better with clinicobiologic subtypes in 131 patients (χ2 = 44, P = 0.005, versus χ2 = 15, P = 0.07 for PRINTO), and ILAR categories aligned better with adult types of arthritis in 389 evaluable patients. Conclusion: Currently identified PRINTO disorders can only be used to classify a minority of JIA patients, leaving a large proportion of JIA patients with other disorders requiring further characterization. Current PRINTO JIA classification criteria do not align better with clinicobiologic subtypes or adult forms of arthritis compared with the older ILAR classification system. [ABSTRACT FROM AUTHOR]

Published
2022
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40. Clinical and Psychosocial Stress Factors are Associated with Decline in Physical Activity Over Time in Children with Juvenile Idiopathic Arthritis

Author

Heale, Liane D, primary, Houghton, Kristin, additional, Rezaei, Elham, additional, Baxter-Jones, Adam D.G., additional, Tupper, Susan M, additional, Muhajarine, Nazeem, additional, Benseler, Susanne M, additional, Boire, Gilles, additional, Cabral, David A, additional, Campillo, Sarah, additional, Chedeville, Gaelle, additional, Chetaille, Anne-Laure, additional, Dancey, Paul, additional, Duffy, Ciaran, additional, Duffy, Karen Watanabe, additional, Ellsworth, Janet, additional, Guzman, Jaime, additional, Huber, Adam M, additional, Jurencak, Roman, additional, Lang, Bianca, additional, Laxer, Ronald M, additional, Morishita, Kimberly, additional, Oen, Keim G, additional, Petty, Ross E, additional, Ramsey, Suzanne E, additional, Roth, Johannes, additional, Schneider, Rayfel, additional, Scuccimarri, Rosie, additional, Spiegel, Lynn, additional, Stringer, Elizabeth, additional, Tse, Shirley M.L., additional, Tucker, Lori B, additional, Turvey, Stuart E, additional, Yeung, Rae S.M., additional, and Rosenberg, Alan M, additional

Published
2021
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41. The iCanCope pain self-management application for adolescents with juvenile idiopathic arthritis: a pilot randomized controlled trial

Author

Lalloo, Chitra, primary, Harris, Lauren R, additional, Hundert, Amos S, additional, Berard, Roberta, additional, Cafazzo, Joseph, additional, Connelly, Mark, additional, Feldman, Brian M, additional, Houghton, Kristin, additional, Huber, Adam, additional, Laxer, Ronald M, additional, Luca, Nadia, additional, Schmeling, Heinrike, additional, Spiegel, Lynn, additional, Tucker, Lori B, additional, Pham, Quynh, additional, Davies-Chalmers, Cleo C, additional, and Stinson, Jennifer N, additional

Published
2020
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46. Parent‐ReportedMedication Side Effects and Their Impact on Health‐RelatedQuality of Life in Children With Juvenile Idiopathic Arthritis

Author

Chédeville, Gaëlle, McGuire, Katherine, Cabral, David A., Shiff, Natalie J., Rumsey, Dax G., Proulx‐Gauthier, Jean‐Philippe, Schmeling, Heinrike, Berard, Roberta A., Batthish, Michelle, Soon, Gordon, Gerhold, Kerstin, Gerschman, Tommy, Bruns, Alessandra, Duffy, Ciaran M., Tucker, Lori B., and Guzman, Jaime

Abstract

To describe the frequency and severity of parent‐reported medication side effects (SEs) in children with juvenile idiopathic arthritis (JIA) relative to physician‐reported actionable adverse events (AEs), and to assess their impact on health‐related quality of life (HRQoL). Newly diagnosed JIA patients recruited between 2017 and 2019 to the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry were included. Parents reported presence and severity (0 = no problem, 10 = very severe) of medication SEs at every clinic visit. Physicians were asked to report any actionable AE. HRQoL was assessed using the Quality of My Life (QoML) questionnaire (0 = the worst, 10 = the best) and parent's global assessment (0 = very well, 10 = very poor). Analyses included proportion of visits with SEs or actionable AEs, cumulative incidence by Kaplan‐Meier methods, and HRQoL impact measured with longitudinal mixed‐effects models. SEs were reported at 371 of 884 (42%) visits (95% confidence interval [95% CI] 39, 45%) in 249 patients, with a median of 2 SEs per visit (interquartile range [IQR] 1–3), and median severity of 3 (IQR 1.5–5). Most SEs were gastrointestinal (32.5% of visits) or behavioral/psychiatric (22.4%). SE frequency was lowest with nonsteroidal antiinflammatory drugs alone (34.7%) and highest with prednisone and methotrexate combinations (66%). SE cumulative incidence was 67% (95% CI 59, 75) within 1 year of diagnosis, and 36% (95% CI 28, 44) for actionable AEs. Parent global and QoML scores were worse with SEs present; the impact persisted after adjusting for pain and number of active joints. Parents report that two‐thirds of children with JIA experience SEs impacting their HRQoL within 1 year of diagnosis. SE mitigation strategies are needed in managing JIA.

Published
2022
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