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344 results on '"TSUKAHARA, SHIGEO"'

2. Impact of Patient Access to Internet Health Records on Glaucoma Medication: Randomized Controlled Trial

Author

Kashiwagi, Kenji and Tsukahara, Shigeo

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundGlaucoma is one of the leading causes of blindness. Reduction of intraocular pressure is the only proven way to prevent progression of glaucomatous optic neuropathy. The majority of glaucoma patients need to use antiglaucoma ophthalmic solutions over the course of their life. Thus, good adherence and persistency of glaucoma treatment are important factors for better glaucoma care. ObjectiveThe purpose of this study was to investigate the impact of an Internet-based glaucoma care support system on glaucoma medication use. MethodsPatients were randomly divided into two groups. The non–Internet access (NIA) group consisted of patients who had access to the Internet-based glaucoma care support system during the 4-year period only when they were examined by ophthalmologists. The Internet access (IA) group consisted of patients who had the same Internet-based glaucoma care support system access as the NIA group for the first 2 years following enrollment but who were also given free access to the glaucoma care support system for the remaining 2 years. Changes in glaucoma medication use were investigated. ResultsIn total, 81 patients in the IA group and 90 patients in the NIA group satisfied the study protocol. The number of antiglaucoma ophthalmic solutions used during the study period significantly increased in the NIA group (P

Published
2014
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24. Postural change of intraocular and blood pressures in ocular hypertension and low tension glaucoma

Author

Yamabayashi, Shigeki, Aguilar, Romulo N., Hosoda, Motohiro, and Tsukahara, Shigeo

Subjects
Intraocular pressure -- Physiological aspects, Body fluids -- Pressure, Intraocular pressure -- Research, Posture -- Physiological aspects, Health
Abstract

Glaucoma is an abnormal condition of elevated intraocular pressure (above 21 millimeters of mercury); it causes gradual loss of peripheral vision, and can lead to blindness. It is well known that changes in posture and body position affect intraocular pressure. A change from sitting to lying is reported by several authors to cause an average increase of 2 to 3 millimeters, or mm, in intraocular pressure. Blood pressure is not correlated with intraocular pressure, but it is related to blood flow. It is believed that abnormalities in the regulation of blood flow at the optic nerve may play a role in the pressure-induced loss of nerve fibers in glaucoma. A study was undertaken to study the relationship between blood pressure and intraocular pressure in two extremes of glaucoma: ocular hypertension, a condition of elevated pressure without eye damage, and low-tension glaucoma, a condition of normal pressure with glaucomatous eye damage. Patients with ocular hypertension, low-tension glaucoma and normal volunteers were studied to determine the effect of posture on intraocular pressure. Moving from sitting to lying down caused an average intraocular pressure increase of 4.4 mm in the controls; 4.0 mm in the ocular hypertension patients and 4.1 mm in the low-tension glaucoma patients. After 30 minutes of lying down, the intraocular pressure remained the same in both the normal volunteers and patients with low-tension glaucoma; the ocular hypertension patients showed a further significant increase of 1.6 mm, as well as a significant decrease in blood pressure. This finding indicates that there are different mechanisms for the regulation of intraocular pressure among these groups. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

42. Successful transportation of human corneal endothelial tissues without cool preservation in varying Indian tropical climatic conditions and in vitro cell expansion using a novel polymer

Author

Rao, Srinivas, Sudhakar, John, Parikumar, Periyasamy, Natarajan, Sundaram, Insaan, Aditya, Yoshioka, Hiroshi, Mori, Yuichi, Tsukahara, Shigeo, Baskar, Subramani, Manjunath, Sadananda, Senthilkumar, Rajappa, Thamaraikannan, Paramasivam, Srinivasan, Thangavelu, Preethy, Senthilkumar, and Abraham, Samuel

Subjects
Endothelium -- Physiological aspects, Cornea -- Transplantation, Polymers -- Usage, Health
Abstract

Byline: Srinivas. Rao, John. Sudhakar, Periyasamy. Parikumar, Sundaram. Natarajan, Aditya. Insaan, Hiroshi. Yoshioka, Yuichi. Mori, Shigeo. Tsukahara, Subramani. Baskar, Sadananda. Manjunath, Rajappa. Senthilkumar, Paramasivam. Thamaraikannan, Thangavelu. Srinivasan, Senthilkumar. Preethy, Samuel. [...]

Published
2014

43. Lack of association between p53 gene polymorphisms and primary open angle glaucoma in the Japanese population

Author

Mabuchi, Fumihiko, Sakurada, Yoichi, Kashiwagi, Kenji, Yamagata, Zentaro, Iijima, Hiroyuki, and Tsukahara, Shigeo

Subjects
Adult, Male, Chi-Square Distribution, Polymorphism, Genetic, genetic structures, Sequence Analysis, DNA, Middle Aged, Genes, p53, eye diseases, Gene Frequency, Japan, Humans, Female, Glaucoma, Open-Angle, Research Article, Aged
Abstract

Purpose To assess whether tumor protein p53 gene (p53) polymorphisms are associated with primary open angle glaucoma (POAG) in the Japanese population. Methods Four hundred and twenty-five Japanese patients with POAG, including normal tension glaucoma (NTG, n=213) and high tension glaucoma (HTG, n=212) and 189 control subjects without glaucoma were analyzed for two p53 polymorphisms (rs1042522; a G→C substitution at codon 72 in exon 4 and rs59758982; a 16 base pair insertion in intron 3) using allele specific primer PCR and a pyrosequencing technique respectively. The genotypic and allelic frequencies were compared between NTG or HTG patients and control subjects. Results No significant difference (NTG versus control, p=0.99, and HTG versus control, p=0.69, χ2 test) was observed regarding the p53 genotype frequencies at codon 72 between the NTG (GG: 43.2%, GC: 44.6%, CC: 12.2%) or HTG (GG: 40.1%, GC: 48.1%, CC: 11.8%) patients and the control subjects (GG: 43.9%, GC: 43.9%, CC: 12.2%). In addition, there was no significant difference (NTG versus control, p=0.94; and HTG versus control, p=0.66, Fisher's exact test) in the p53 allele frequencies at codon 72 between the NTG (G allele: 65.5%, C allele: 34.5%) or HTG (G allele: 64.2%, C allele: 35.8%) patients and the control subjects (G allele: 65.9%, C allele: 34.1%). No 16 base pair insertion in intron 3 was found in this study. Conclusion p53 polymorphisms were not associated with POAG in the Japanese population. Further studies in the other ethnic populations should therefore be performed to elucidate whether the p53 intron 3 insertion polymorphism is a genetic risk factor for POAG, because the intron 3 insertion polymorphism occurs very rarely in the Japanese population.

Published
2009

44. Efficacy and Safety of Switching Prostaglandin Analog Monotherapy to Tafluprost/Timolol Fixed-Combination Therapy

Author

Kitamura, Kazuyoshi, primary, Chiba, Tatsuya, additional, Mabuchi, Fumihiko, additional, Ishijima, Kiyotaka, additional, Omoto, Shu, additional, Kashiwagi, Fumiko, additional, Godo, Takashi, additional, Kogure, Satoshi, additional, Goto, Teruhiko, additional, Shibuya, Takashi, additional, Tanabe, Jhoji, additional, Tsukahara, Shigeo, additional, Tsuchiya, Tadaharu, additional, Tsumura, Toyoaki, additional, Tokunaga, Takaharu, additional, Hosaka, Osamu, additional, Saito, Tetsunori, additional, and Kashiwagi, Kenji, additional

Published
2018
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45. Lysyl oxidase-like 1 gene polymorphisms in Japanese patients with primary open angle glaucoma and exfoliation syndrome

Author

Mabuchi, Fumihiko, Sakurada, Yoichi, Kashiwagi, Kenji, Yamagata, Zentaro, Iijima, Hiroyuki, and Tsukahara, Shigeo

Subjects
Adult, Aged, 80 and over, Male, Polymorphism, Genetic, Genotype, Middle Aged, Exfoliation Syndrome, eye diseases, Asian People, Gene Frequency, Japan, Case-Control Studies, Humans, Female, Amino Acid Oxidoreductases, Glaucoma, Open-Angle, Research Article, Aged, Demography
Abstract

Purpose To assess whether lysyl oxidase-like 1 (LOXL1) polymorphisms are associated with primary open-angle glaucoma (POAG) and exfoliation syndrome (XFS). Methods Japanese patients with POAG (n=213) or XFS (n=89) and 191 control subjects were analyzed for LOXL1 polymorphisms (rs1048661: 758G/T, Arg141Leu and rs3825942: 794G/A, Gly153Asp). Demographic and clinical features of POAG patients and control subjects were compared in terms of the TT/GG compound genotype of rs1048661 and rs3825942. Results There was a significant difference in the genotype frequencies between XFS patients and control subjects (p

Published
2008

49. Successful transportation of human corneal endothelial tissues without cool preservation in varying Indian tropical climatic conditions and in vitro cell expansion using a novel polymer

Author

Abraham, SamuelJ K, primary, Rao, SrinivasK, additional, Sudhakar, John, additional, Parikumar, Periyasamy, additional, Natarajan, Sundaram, additional, Insaan, Aditya, additional, Yoshioka, Hiroshi, additional, Mori, Yuichi, additional, Tsukahara, Shigeo, additional, Baskar, Subramani, additional, Manjunath, SadanandaRao, additional, Senthilkumar, Rajappa, additional, Thamaraikannan, Paramasivam, additional, Srinivasan, Thangavelu, additional, and Preethy, Senthilkumar, additional

Published
2014
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