42 results on '"TRABECULAR CARCINOMA"'
Search Results
2. Merkel cell carcinoma: literature review.
- Author
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Al‐Zawi, Abdalla Saad Abdalla, Prodromou, Andrew, Chicken, Wayne, Comez, Turhan, and Deniz, Ekin
- Subjects
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MERKEL cell carcinoma , *AXONS , *MERKEL cells , *POLYOMAVIRUSES , *MECHANORECEPTORS - Abstract
Merkel cell carcinoma (MCC) was given a such name after the German histopathologist Friedrich Merkel, who first in 1875, described the Merkel cells, as small round or oval basophilic cells located at the end of nerve axons and within the basal layer of the epidermis. The current agreement about the function of Merkel cells they are associated with the nerve terminals acting as mechanoreceptors. MCC is a clinically aggressive uncommon, cutaneous neuroendocrine neoplastic tumour with a high mortality rate. Clinically may be presented as a painless, rapidly growing, dome-shaped red or purplish nodule. Usually in a sun-exposed area of the head and neck or upper limbs. Tremendous effort has been done in the last few years for a better understanding of the pathogenesis behind the MCC and the discovery of the Merkel cell polyomavirus suggests another clue to its pathogenesis. The expression of both epithelial and neuroendocrine immunohistochemical markers in the malignant cells, gives the tumour a unique feature that helps differentiate this neoplasm from other entities. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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3. Merkel cell carcinoma: a review and update on current concepts.
- Author
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Cook, Deborah L. and Frieling, Gretchen W.
- Abstract
Merkel cell carcinoma (MCC) is a malignant, cutaneous neuroendocrine tumour of the elderly with an increasing worldwide incidence. Clinical presentation is generally characterized by a rapidly-evolving dermal tumour on sun-exposed skin of the head, neck or extremities. Histologically, there are sheets and cords of uniform, small cells with hyperchromatic nuclei and multiple small nucleoli. Mitoses and apoptotic bodies are widespread and lymphovascular involvement is commonly present. Aggressive surgical treatment of localized primary lesions followed by radiotherapy remains the mainstay of treatment. Lymph node metastases, local recurrences, and widespread dissemination are commonly seen. The 10-year survival rates for MCC are 71%, 48%, and 20% for localized, regional, and distant disease, respectively. Merkel cell polyomavirus (MCV) has been implicated as a contributing factor in the pathogenesis of MCC with approximately 80% of tumours showing positivity for the virus. This review provides an up-to-date overview of the clinicopathologic features, current knowledge of MCV, and recent advances in diagnosis, prognostication, and management of MCC. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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4. Mesenchymal Tumors
- Author
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Braun-Falco, Otto, Plewig, Gerd, Wolff, Helmut H., Winkelmann, Richard K., Braun-Falco, Otto, Plewig, Gerd, Wolff, Helmut H., and Winkelmann, Richard K.
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- 1991
- Full Text
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5. A Report of 13 Cases of Merkel Cell Carcinoma: Single-Center Experience and Review of the Literature
- Author
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Elif Irmak Yazici, Kenan Aydogan, Hayriye Sarıcaoğlu, Serkan Yazici, Emel Bülbül Başkan, and Saduman Balaban Adim
- Subjects
Turkish population ,Pediatrics ,medicine.medical_specialty ,Dermatology ,Pathogenesis ,Single Center ,Mechanoreceptor ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Merkel cell carcinoma ,medicine ,Overall survival ,Trabecular carcinoma ,Merkel cell ,business.industry ,Medical record ,medicine.disease ,Prognosis ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Neuroendocrine carcinoma ,Referral center ,Original Article ,business - Abstract
Background: There is limited data knowledge of Merkel cell carcinoma (MCC) in Turkey aside from a few case reports. Objective: The aim of this study was to describe the clinical characteristics, demographic features, therapeutic parameters, and outcome of primary cutaneous MCC cases from Turkey. Methods: Digital medical records of the 13 MCC patients who were followed-up at a tertiary referral center were retrospectively analyzed. Clinic, demographic, tumor characteristics, and survival of the patients were retrieved. Results: Most of our patients were elderly. Female predominance was noticed. The most common primary site of the tumors was the lower extremities. The overall survival was 42 months, 68% at first year, 68% at third years, and 29% at fifth years. Conclusion: This is the first largest report from Turkish population with female predominance, and lower extremity tendency. (Ann Dermatol 31(3) 272∼278, 2019)
- Published
- 2019
6. Merkel Cell Carcinoma: Differences between Sun-Exposed and Non-Sun-Exposed Variants - A Clinical Analysis of 36 Cases.
- Author
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Marcoval, Joaquim, Ferreres, Josep Ramon, Penín, Rosa María, Pérez, Diana, and Viñals, Joan Maria
- Abstract
Background: There are few studies focusing on the clinical characteristics of Merkel cell carcinoma (MCC). Objective: To retrospectively analyze the clinical features of our patients and their relationship with sun exposure. Methods: Thirty-six patients diagnosed with MCC (20 men and 16 women, mean age 72.08 years) were included in the study. Results: 21 patients developed MCC in sun-exposed skin and 15 patients in non-sun-exposed areas. MCC was >2 cm in 19 cases. Six of the 7 patients who died as a result of MCC had non-sun-exposed tumors. Only tumor size >2 cm significantly influenced survival (p = 0.033). Conclusion: Sun-exposed lesions tended to be <2 cm in diameter and were more common in men, while non-sun-exposed tumors were larger, usually occurring in women and carrying a greater likelihood of death by MCC. Non-sun-exposed tumors usually present as fast-growing, multilobar nodular lesions with a smooth shiny surface. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
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- 2014
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7. Merkel cell carcinoma of the head and neck.
- Author
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Pellitteri, Phillip K., Takes, Robert P., Lewis, James S., Devaney, Kenneth O., Harlor, Evan J., Strojan, Primož, Rodrigo, Juan P., Suárez, Carlos, Rinaldo, Alessandra, Medina, Jesus E., Woolgar, Julia A., Ferlito, Alfio, and Eisele, David W.
- Subjects
MERKEL cell carcinoma ,HEAD tumors ,NECK tumors ,SKIN cancer ,CHROMATIN ,LYMPHOMAS ,RADIOTHERAPY - Abstract
Merkel cell carcinomas are uncommon, but aggressive, cutaneous malignancies of neuroendocrine differentiation. To the pathologist, these lesions appear as sheets of undifferentiated tumor cells with little cytoplasm and dense nuclear chromatin. They are members of the group of 'small round blue cell tumors,' which includes small cell carcinomas of the lung, lymphomas, and neuroblastomas. Analogous to other skin malignancies, Merkel cell carcinomas frequently arise in the head and neck region and are commonly found in the elderly population. Merkel cell carcinomas have a high propensity for regional and distant metastases, and recurrences are frequently seen. Surgical excision is the recommended first-line treatment followed by adjuvant radiation therapy. Because of the high incidence of occult regional metastasis, patients with clinical and radioghaphically negative necks should undergo elective dissection, irradiation, or preferably sentinel lymph node biopsy. © 2011 Wiley Periodicals, Inc. Head Neck, 2012 [ABSTRACT FROM AUTHOR]
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- 2012
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8. Reviewing the current evidence supporting early B-cells as the cellular origin of Merkel cell carcinoma
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EXPRESSION ,Cutaneous B-cell lymphoma ,Merkel cell ,Stem cell ,B-cell differentiation ,Lymphoma ,POLYOMAVIRUS INFECTION ,TYROSINE KINASE ,Pathogenesis ,Cell of origin ,POTENTIAL DIAGNOSTIC PITFALL ,Merkel cell carcinoma ,PRE-B ,PDGFR-ALPHA ,Merkel cell polyoma virus ,TISSUE MICROARRAY ,STEM-CELLS ,Oncogenesis ,TRABECULAR CARCINOMA ,KIT RECEPTOR - Abstract
Merkel cell carcinoma (MCC) is a highly malignant skin cancer characterized by early metastases and poor survival. Although MCC is a rare malignancy, its incidence is rapidly increasing in the U.S. and Europe. The discovery of the Merkel cell polyomavirus (MCPyV) has enormously impacted our understanding of its etiopathogenesis and biology. MCCs are characterized by trilinear differentiation, comprising the expression of neuroendocrine, epithelial and B-lymphoid lineage markers. To date, it is generally accepted that the initial assumption of MCC originating from Merkel cells (MCs) is unlikely. This is owed to their post-mitotic character, absence of MCPyV in MCs and discrepant protein expression pattern in comparison to MCC. Evidence from mouse models suggests that epidermal/dermal stem cells might be of cellular origin in MCC. The recently formulated hypothesis of MCC originating from early B-cells is based on morphology, the consistent expression of early B-cell lineage markers and the finding of clonal immunoglobulin chain rearrangement in MCC cells. In this review we elaborate on the cellular ancestry of MCC, the identification of which could pave the way for novel and more effective therapeutic regimens. (C) 2017 The Authors. Published by Elsevier Ireland Ltd.
- Published
- 2017
9. Reviewing the current evidence supporting early B-cells as the cellular origin of Merkel cell carcinoma
- Author
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Christopher Martin Sauer, Anna Kordelia Kurz, Véronique Winnepenninckx, Emil Chteinberg, A. zur Hausen, Dorit Rennspiess, Jürgen C. Becker, Anke Haugg, and Ernst J. M. Speel
- Subjects
0301 basic medicine ,Pathology ,Skin Neoplasms ,B-cell differentiation ,Lymphoma ,Cell of origin ,Medizin ,Merkel cell polyomavirus ,TYROSINE KINASE ,Pathogenesis ,medicine.disease_cause ,POTENTIAL DIAGNOSTIC PITFALL ,Merkel cell carcinoma ,0302 clinical medicine ,Merkel cell polyoma virus ,TRABECULAR CARCINOMA ,KIT RECEPTOR ,B-Lymphocytes ,Cutaneous B-cell lymphoma ,Stem cell ,integumentary system ,biology ,POLYOMAVIRUS INFECTION ,food and beverages ,Hematology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Merkel cell ,STEM-CELLS ,EXPRESSION ,medicine.medical_specialty ,03 medical and health sciences ,medicine ,Animals ,Humans ,Cell Lineage ,PDGFR-ALPHA ,ddc:610 ,TISSUE MICROARRAY ,Oncogenesis ,Lineage markers ,medicine.disease ,biology.organism_classification ,Carcinoma, Merkel Cell ,030104 developmental biology ,PRE-B ,Skin cancer ,Carcinogenesis - Abstract
Critical reviews in oncology, hematology 116, 99 - 105(2017). doi:10.1016/j.critrevonc.2017.05.009, Published by Elsevier Science, Amsterdam [u.a.]
- Published
- 2017
10. Immunohistochemical and ultrastructural investigation on cutaneous neuroendocrine carcinoma: report of a case and review of the literature.
- Author
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Ishii, Hideaki, Joshita, Takashi, Matsuyama, Nagahisa, Uchida, Takashi, Ishikawa, Akio, and Ebihara, Yoshiro
- Subjects
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TUMORS , *DISEASES in older people , *LUNG cancer , *NEUROENDOCRINE tumors , *IMMUNOHISTOCHEMISTRY - Abstract
We report a tumor in an 80-year-old man that was difficult to distinguish from other tumors, i.e., small cell carcinoma of the lung, PNET/Ewing tumor, malignant lymphoma, or malignant melanoma (amelanotic), and which was finally identified as cutaneous neuroendocrine carcinoma using immunohistochemical and ultrastructural methods. Autopsy did not show any tumors in the lungs, excluding the possibility of small cell carcinoma of the lung. Immunohistochemistry tests gave negative results for LCA, UCHL-1, CD3, and CD20, thereby excluding malignant lymphoma, and the negative results for S-100 protein and HMB-45 ruled out malignant melanoma. The possibility of PNET/Ewing sarcoma was also excluded because of negativity for CD99. In addition, the ultramicrostructure showed intercellular junctional complexes and neuroendocrine granules, indicating that the tumor had characteristics of both epithelial and neuroendocrine tissues. We therefore diagnosed the primary carcinoma of the skin as cutaneous neuroendocrine carcinoma. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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11. Merkelzellkarzinom
- Subjects
EXPRESSION ,T-ANTIGEN ,TUMOR ,IDENTIFICATION ,POLYOMAVIRUS ,RECURRENCE ,GENE ,TRABECULAR CARCINOMA ,SKIN ,POTENTIAL DIAGNOSTIC PITFALL - Abstract
Merkel cell carcinoma (MCC) is a relatively rare but highly malignant non-melanoma skin cancer of the elderly and immunosuppressed patients. The discovery of the Merkel cell polyomavirus (MCPyV) in 2008 significantly impacted the understanding of the etiopathogenesis of MCC. MCPyV is clonally integrated into the MCC genome and approximately 80% of MCC are MCPyV-positive. Recent results of clinical trials using blockade of the PD-1 immune modulatory pathway are promising for the future treatment of MCC. Despite this major progress of the past few years, the cellular origin of MCC still remains obscure. Based on histomorphology, gene expression profiling, and molecular analyses, we have recently hypothesized that MCC originates from preaEuro/pro-B cells. Here we review putative cells of MCC, including Merkel cells, (epiaEuro)dermal stem cells, and proaEuro/pre-B cells. In the present work, the focus is on the concept of preaEuro/pro-B cells as the cellular origin of MCC, which might also impact the understanding of other human small cell malignancies of unknown cellular origin, such as small cell carcinomas of the lung and other anatomical locations. In addition, this concept might pave the way for novel treatment options, especially for advanced MCC.
- Published
- 2017
12. Merkel cell carcinoma in the orbitopalpebral region.
- Author
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Onesti, Maria Giuseppina, Mazzocchi, Marco, and Scuderi, Nicolò
- Subjects
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MERKEL cell carcinoma , *SKIN cancer , *NEUROENDOCRINE tumors , *PLASTIC surgery , *BIOPSY - Abstract
Trabecular carcinoma is a rare cutaneous neuroendocrine carcinoma that probably originates from the Merkel cells that are usually found in the basal layer of the epidermis. The treatment of Merkel cell carcinoma is controversial and there is no specific therapeutic protocol because of the small number of cases that have been published. The procedures used to treat Merkel cell carcinoma must be tailored to minimise morbidity while maximising survival. Because the condition is so rare and difficult to diagnose and treat, we report three cases of orbitopalpebral tumours that confirm the local and regional aggressiveness and the high metastatic potential of this tumour. [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF
13. Giant Hyalinizing Trabecular Carcinoma of the Thyroid Gland in a 20-Years Old Male Patient
- Author
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Michael S Papageorgiou
- Subjects
Pathology ,medicine.medical_specialty ,medicine.anatomical_structure ,Male patient ,business.industry ,Thyroid ,medicine ,Trabecular carcinoma ,business - Published
- 2018
14. Klinik und Therapie des Merkelzelltumors.
- Author
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Hellner, D., Meyer-Pannwitt, U., Rose, R., Gundlach, K., and Schreiber, H.
- Abstract
Copyright of Langenbecks Archiv fuer Chirurgie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 1988
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15. Merkelzellkarzinom: kutane Manifestation einer hochmalignen Prä-/pro-B-Zell-Neoplasie?
- Author
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Sauer, C. M., Chteinberg, E., Rennspiess, D., Kurz, A. K., zur Hausen, A., Pathologie, Promovendi ODB, RS: GROW - R2 - Basic and Translational Cancer Biology, and MUMC+: DA Klinische Pathologie (5)
- Subjects
EXPRESSION ,0301 basic medicine ,T-ANTIGEN ,IDENTIFICATION ,POLYOMAVIRUS ,Dermatology ,GENE ,POTENTIAL DIAGNOSTIC PITFALL ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,TUMOR ,030220 oncology & carcinogenesis ,RECURRENCE ,TRABECULAR CARCINOMA ,SKIN - Abstract
Der Hautarzt 68(3), 204 - 210(2017). doi:10.1007/s00105-017-3945-0, Published by Springer, Berlin
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- 2017
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16. Merkel Cell Carcinoma: Differences between Sun-Exposed and Non-Sun-Exposed Variants - A Clinical Analysis of 36 Cases
- Author
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Josep Ramon Ferreres, R.M. Penín, Joan Maria Viñals, Diana Pérez, and Joaquim Marcoval
- Subjects
Adult ,Male ,endocrine system ,Pathology ,medicine.medical_specialty ,Disease free survival ,Skin Neoplasms ,endocrine system diseases ,Treatment outcome ,Dermatology ,Risk Assessment ,Disease-Free Survival ,Cohort Studies ,Hospitals, University ,medicine ,Carcinoma ,Humans ,Neoplasm Invasiveness ,Survival analysis ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,integumentary system ,Clinical pathology ,Merkel cell carcinoma ,business.industry ,Biopsy, Needle ,virus diseases ,food and beverages ,Trabecular carcinoma ,Middle Aged ,Prognosis ,medicine.disease ,Immunohistochemistry ,Survival Analysis ,Carcinoma, Merkel Cell ,Treatment Outcome ,Spain ,Sunlight ,Female ,Neoplasm staging ,business - Abstract
Background: There are few studies focusing on the clinical characteristics of Merkel cell carcinoma (MCC). Objective: To retrospectively analyze the clinical features of our patients and their relationship with sun exposure. Methods: Thirty-six patients diagnosed with MCC (20 men and 16 women, mean age 72.08 years) were included in the study. Results: 21 patients developed MCC in sun-exposed skin and 15 patients in non-sun-exposed areas. MCC was >2 cm in 19 cases. Six of the 7 patients who died as a result of MCC had non-sun-exposed tumors. Only tumor size >2 cm significantly influenced survival (p = 0.033). Conclusion: Sun-exposed lesions tended to be
- Published
- 2014
17. Eyelid and Periocular Cutaneous Merkel Cell Carcinoma (aka. Neuroendocrine or Trabecular Carcinoma)
- Author
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Rhonda V. Barrett and Dale R. Meyer
- Subjects
Pathology ,medicine.medical_specialty ,Skin Neoplasms ,business.industry ,Merkel cell carcinoma ,Incidence ,Trabecular carcinoma ,Eyelid Neoplasms ,Prognosis ,medicine.disease ,Combined Modality Therapy ,United States ,Carcinoma, Neuroendocrine ,Carcinoma, Merkel Cell ,Diagnosis, Differential ,Ophthalmology ,medicine.anatomical_structure ,Risk Factors ,medicine ,Humans ,Eyelid ,Facial Neoplasms ,business ,AKA - Published
- 2009
18. Merkel cell carcinoma in the orbitopalpebral region
- Author
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Nicolò Scuderi, Marco Mazzocchi, and Maria Giuseppina Onesti
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,trabecular carcinoma ,Cutaneous Neuroendocrine Carcinoma ,Tumor cells ,sentinel node biopsy ,merkel cell carcinoma ,Basal (phylogenetics) ,Postoperative Complications ,medicine ,Carcinoma ,Humans ,Aged ,orbito-palpebral region ,Aged, 80 and over ,integumentary system ,business.industry ,Merkel cell carcinoma ,Eyelids ,General Medicine ,Trabecular carcinoma ,Merkel cell carcinoma, Orbito-palpebral region, Sentinel node biopsy, Trabecular carcinoma ,Plastic Surgery Procedures ,medicine.disease ,Carcinoma, Merkel Cell ,medicine.anatomical_structure ,Head and Neck Neoplasms ,Female ,Epidermis ,Merkel cell ,business - Abstract
Trabecular carcinoma is a rare cutaneous neuroendocrine carcinoma that probably originates from the Merkel cells that are usually found in the basal layer of the epidermis. The treatment of Merkel cell carcinoma is controversial and there is no specific therapeutic protocol because of the small number of cases that have been published. The procedures used to treat Merkel cell carcinoma must be tailored to minimise morbidity while maximising survival. Because the condition is so rare and difficult to diagnose and treat, we report three cases of orbitopalpebral tumours that confirm the local and regional aggressiveness and the high metastatic potential of this tumour.
- Published
- 2005
19. Hyalinizing trabecular carcinoma of the thyroid gland
- Author
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S Gowrishankar, S A Pai, and J A Carney
- Subjects
Pathology ,medicine.medical_specialty ,Histology ,medicine.anatomical_structure ,business.industry ,Thyroid ,medicine ,General Medicine ,Trabecular carcinoma ,business ,Pathology and Forensic Medicine - Published
- 2008
20. A Report of 13 Cases of Merkel Cell Carcinoma: Single-Center Experience and Review of the Literature.
- Author
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Yazici S, Irmak Yazici E, Balaban Adim S, Bulbul Baskan E, Aydoğan K, and Saricaoğlu H
- Abstract
Background: There is limited data knowledge of Merkel cell carcinoma (MCC) in Turkey aside from a few case reports., Objective: The aim of this study was to describe the clinical characteristics, demographic features, therapeutic parameters, and outcome of primary cutaneous MCC cases from Turkey., Methods: Digital medical records of the 13 MCC patients who were followed-up at a tertiary referral center were retrospectively analyzed. Clinic, demographic, tumor characteristics, and survival of the patients were retrieved., Results: Most of our patients were elderly. Female predominance was noticed. The most common primary site of the tumors was the lower extremities. The overall survival was 42 months, 68% at first year, 68% at third years, and 29% at fifth years., Conclusion: This is the first largest report from Turkish population with female predominance, and lower extremity tendency., Competing Interests: CONFLICTS OF INTEREST: The authors have nothing to disclose., (Copyright © 2019 The Korean Dermatological Association and The Korean Society for Investigative Dermatology.)
- Published
- 2019
- Full Text
- View/download PDF
21. [Merkel cell carcinoma: a presentation of 5 cases and a review of the literature]
- Author
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Juan Luis Gómez González, Pablo Santos Gorjón, Juan Carlos del Pozo de Dios, Alberto Romo Melgar, Pedro Blanco Pérez, and Ana Cristina Morales Martín
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Skin Neoplasms ,Diagnosis, Differential ,Neoplasms, Multiple Primary ,Neoplasm Recurrence ,Carcinoma ,Biomarkers, Tumor ,Medicine ,Humans ,Neoplasm Invasiveness ,Forehead ,Ear, External ,Laryngeal Neoplasms ,Aged ,Retrospective Studies ,Aged, 80 and over ,integumentary system ,business.industry ,Merkel cell carcinoma ,General Medicine ,Trabecular carcinoma ,Laryngeal Neoplasm ,Cheek ,medicine.disease ,Dermatology ,Combined Modality Therapy ,Carcinoma, Merkel Cell ,medicine.anatomical_structure ,Carcinoma, Basal Cell ,Head and Neck Neoplasms ,Carcinoma, Squamous Cell ,Female ,Presentation (obstetrics) ,Facial Neoplasms ,Neoplasm Recurrence, Local ,business - Abstract
Merkel cell carcinoma is an unusual, aggressive skin tumour, with a tendency to recur after its surgical extirpation. Five cases of tumours in the cervicofacial region seen at our Centre in the last 5 years are presented, along with a review of the literature, focusing on its etiopathogeneis, approach and treatment. © 2010 Elsevier EspaS.L. All rights reserved.
- Published
- 2010
22. Epidemiology of Merkel Cell Carcinoma
- Author
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Jean Kanitakis and Wen Lyn Ho
- Subjects
Pathology ,medicine.medical_specialty ,integumentary system ,Merkel cell carcinoma ,business.industry ,Puva treatment ,food and beverages ,Trabecular carcinoma ,medicine.disease ,medicine.anatomical_structure ,Cutaneous carcinoma ,Polyoma virus ,Epidemiology ,medicine ,Immunohistochemistry ,Merkel cell ,business - Abstract
Merkel cell carcinoma (MCC), also known as primary neuroendocrine or trabecular carcinoma of the skin, is an aggressive primary cutaneous carcinoma first described by Toker in 1972 [21]. MCC cells share ultrastructural and immunohistochemical neuroendocrine features with epidermal Merkel cells, but their precise histogenetic origin remains uncertain.
- Published
- 2010
23. Merkel cell tumor of the eyelid and the cytologic aspect in fine-needle aspirates: report of a case
- Author
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J. Sola‐Pérez, C. Abad‐Montaño, Miguel Pérez-Guillermo, F. A. Pastor Quirante, and M. S. Án Montalb Romero
- Subjects
Merkel cell tumor ,Pathology ,medicine.medical_specialty ,Histology ,Skin Neoplasms ,medicine.diagnostic_test ,business.industry ,Biopsy, Needle ,General Medicine ,Trabecular carcinoma ,Eyelid Neoplasms ,Immunohistochemistry ,Pathology and Forensic Medicine ,Carcinoma, Merkel Cell ,Fine-needle aspiration ,medicine.anatomical_structure ,Cytology ,Mitotic Figure ,medicine ,Humans ,Female ,Eyelid ,business ,Merkel cell ,Aged - Abstract
We describe one case of Merkel cell tumor (MCT) of the eyelid diagnosed by fine-needle aspiration (FNA). The main cytologic features were: isolated cells, loose cohesive sheets, and rosette-like structures in a hematic background. The cells were round to ovoid and very uniform. Chromatin was finely granular and frequent mitotic figures were observed. Under close scrutiny small faintly stained juxtanuclear “caps” were seen. A strong dot-like positivity for CK22 and NFP was observed in the position corresponding to the “caps.” NSE positivity was diffuse, although a weak dot-like positivity was seen in some cells. S-100 was negative. Both the cytologic features and the immunocytologic profile of Merkel cell turmor are very characteristic. FNA enables an early and confident diagnosis of this aggressive tumor and an early planning of surgery. © 1994 Wiley-Liss, Inc.
- Published
- 1994
24. Merkel cell (trabecular) carcinoma of skin treated by radiotherapy
- Author
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A.Y. Rostom, A.D. Stockdale, and J.D. Brierley
- Subjects
Aged, 80 and over ,Male ,medicine.medical_specialty ,Skin Neoplasms ,Palliative treatment ,business.industry ,Merkel cell tumour ,medicine.medical_treatment ,Trabecular carcinoma ,Primary Neoplasm ,Surgery ,Carcinoma, Merkel Cell ,Radiation therapy ,medicine.anatomical_structure ,Oncology ,medicine ,Humans ,Female ,Radiology, Nuclear Medicine and imaging ,Facial Neoplasms ,Head and neck ,business ,Merkel cell ,Lymph node ,Aged - Abstract
Merkel cell tumour is a recently described aggressive primary neoplasm of the skin. It is commonly seen in the elderly, on the head and neck or extremities. Surgical excision is the recommended treatment, but local recurrence or dissemination is not an uncommon consequence of this form of therapy. Radiotherapy is usually used as a palliative treatment for metastatic disease. We present two patients, in one an extensive primary was controlled by superficial X-ray, in the other, lymph node metastases were controlled with radiotherapy after excision of the primary.
- Published
- 1991
25. Whatʼs in a name?
- Author
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Gurdip S. Sidhu
- Subjects
Pathology ,medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,medicine ,Neoplasm ,Dermatology ,General Medicine ,Trabecular carcinoma ,medicine.disease ,business ,Merkel cell ,Pathology and Forensic Medicine - Published
- 1982
26. 'Murky cell' carcinoma (formerly trabecular carcinoma)
- Author
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Jere B. Stern
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Medicine ,Basal cell ,Dermatology ,General Medicine ,Trabecular carcinoma ,Anatomy ,business ,Yet another ,Pathology and Forensic Medicine - Published
- 1982
27. Trabecular or Merkel-Cell Carcinoma of the Skin
- Author
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Arthur B. Abt, Herbert A. Ecker, Stephen J. Herceg, and William P. Graham
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Node metastasis ,Merkel cell carcinoma ,business.industry ,Trabecular carcinoma ,Adenocarcinoma ,Middle Aged ,Prognosis ,Skin appendage ,medicine.disease ,Malignancy ,Lesion ,Rare tumor ,medicine ,Humans ,Female ,Surgery ,medicine.symptom ,business ,Aged - Abstract
The Merkel-cell tumor (trabecular carcinoma) is an unusual skin appendage malignancy that often recurs locally after initial excision. Occasional regional node metastasis occurs with the larger lesions. This report details our experience with six patients who developed this lesion. Illustrated is a spectrum of malignancy from a locally limited tumor to ones that led to death of the patients. Recognition of this rare tumor is important to ensure proper local treatment with close follow-up observation of the patient.
- Published
- 1982
28. Malignant Merkel-cell tumor is a more accurate description than trabecular carcinoma
- Author
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Rywlin Am
- Subjects
Oncology ,medicine.medical_specialty ,Merkel cell tumor ,Skin Neoplasms ,business.industry ,Dermatology ,General Medicine ,Trabecular carcinoma ,Adenocarcinoma ,medicine.disease ,Pathology and Forensic Medicine ,Text mining ,Terminology as Topic ,Internal medicine ,medicine ,Cancer research ,Humans ,business - Published
- 1982
29. Klinik und Therapie des Merkelzelltumors
- Author
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Gundlach Kh, H. W. Schreiber, D. Hellner, R. Rose, and U. Meyer-Pannwitt
- Subjects
Gynecology ,medicine.medical_specialty ,Lymphatic metastasis ,Merkel cell tumor ,business.industry ,Hematogenous metastasis ,medicine ,Surgery ,Trabecular carcinoma ,business - Abstract
Es wird uber vier Falle eines Merkelzelltumors mit unterschiedlichem klinischen Verlauf und Lokalisation im Gesicht und am Stamm berichtet. Bezuglich der Klinik wurden 339 Falle eines Merkelzelltumors aus der Literatur ausgewertet. Beim Merkelzelltumor handelt es sich um einen von den Merkelschen Zellen ausgehenden neuroendokrinen Hauttumor. Er findet sich zu 47% im Kopf-Halsbereich, hat eine durchschnittliche Grose von 25 mm, liegt typischerweise uber dem Hautniveau und zeichnet sich klinisch durch seine rotlich-livide Farbe aus. Aufgrund der Metastasierung und des infiltrativen Wachstums ist er als maligne einzuordnen. In 27% bestehen Lymphknotenmetastasen, in 51 % kommt es zu Lokalrezidiven und in 32% treten Fernmetastasen auf. Die Therapie der Wahl besteht in einer fruhzeitigen Excision mit einem Sicherheitsabstand, wie er bei malignen Hauttumoren ublich ist. Eine Strahlensensibilitat liegt vor; ob auch eine chemotherapeutische Beeinflusbarkeit besteht, ist jedoch nicht sicher.
- Published
- 1988
30. Orbito-palpebral Lesions in Merkel-Cell Tumors: Diagnosis, Treatment
- Author
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M. L. Herdan, Morax S, and M. Fendri
- Subjects
Lid margin ,Pathology ,medicine.medical_specialty ,Merkel cell tumor ,genetic structures ,integumentary system ,business.industry ,medicine.medical_treatment ,Trabecular carcinoma ,eye diseases ,Radiation therapy ,Ophthalmology ,Palpebral fissure ,medicine.anatomical_structure ,Diagnosis treatment ,medicine ,sense organs ,business ,Intermediate filament ,Merkel cell - Abstract
Merkel-cell tumor was first described by Toker in 1972, as 'trabecular carcinoma', then a couple of years later, it was considered as involving the Merkel cell because of its characteristic neurosecretory granulations and intermediate filaments. Based on four cases, three involving the lids, one the orbital rim, the authors briefly summarize the current thoughts concerning the Merkel cell tumor, its clinical features, histological appearance and diagnosis, its prognosis and therapeutic management.
- Published
- 1989
31. Trabecular carcinoma of the skin. An ultrastructural study
- Author
-
Cyril Toker and Chik-Kwun Tang
- Subjects
Cancer Research ,Frozen section procedure ,Merkel cell tumor ,Pathology ,medicine.medical_specialty ,integumentary system ,Skin tumor ,Trabecular carcinoma ,Anatomy ,Biology ,medicine.anatomical_structure ,Oncology ,medicine ,Ultrastructure ,Merkel cell ,Electron microscopic ,Neurosecretory granules - Abstract
We report the electron microscopic studies of three trabecular carcinomas of the skin. The presence of neurosecretory granules in all three tumors suggests that trabecular carcinoma originates from one of the neurocrest derivatives, most probably, Merkel cells. The ultrastructural findings confirm Toker's original concept that trabecular carcinomas comprise a distinct group of skin tumor. The recognition of these tumors would enable one to make such a diagnosis on frozen section, which, in turn, might provide an opportunity for more specific cytochemical and immunofluorescent characterization.
- Published
- 1978
32. Trabecular carcinoma of the skin
- Author
-
Cyril Toker
- Subjects
Male ,Merkel cell tumor ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Merkel cell polyomavirus ,Dermatology ,Adenocarcinoma ,Diagnosis, Differential ,Dermis ,medicine ,Humans ,Neoplasm Metastasis ,Aged ,biology ,Merkel cell carcinoma ,business.industry ,Trabecular carcinoma ,Anatomy ,General Medicine ,medicine.disease ,biology.organism_classification ,medicine.anatomical_structure ,Lymphatic system ,Lymphatic Metastasis ,Female ,Merkel cell ,business ,Cutaneous malignancy - Abstract
Five patients had trabecular carcinomas of the skin. The growths originate within the dermis or in the immediate subcutis, and display a uniform morphology. They are composed of solid trabeculae that lack definite acini. A derivation from cells that are capable of reproducing primitive sudoriferous structures is postulated. The lesions have been encountered in elderly patients of both sexes, and the larger tumors have disseminated actively by lymphatic pathways. Trabecular carcinomas may occasion diagnostic difficulty, for they may be misinterpreted as cutaneous metastases from visceral cancers. The histological features of these tumors are not sufficiently distinctive to permit differentiation from anaplastic metastatic carcinomas. Confirmation of their primary dermal origin is dependent upon the clinical outcome. Familiarity with their existence is, however, of importance in the evaluation of cutaneous malignancy.
- Published
- 1972
33. Primary cutaneous neuroendocrine (Merkel cell or trabecular carcinoma) tumour of the skin: a radioresponsive tumour
- Author
-
D.H. Jones, A.J. Blackshaw, A.D. Tasker, and M.A. Ashby
- Subjects
Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Nodal irradiation ,medicine.medical_treatment ,Biopsy ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Neoplasm Metastasis ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Wide local excision ,General Medicine ,Trabecular carcinoma ,Primary lesion ,Carcinoma, Merkel Cell ,Radiation therapy ,medicine.anatomical_structure ,Female ,Neoplasm Recurrence, Local ,business ,Merkel cell ,NODAL - Abstract
Four patients with primary neuroendocrine carcinoma of the skin (Merkel cell or trabecular carcinoma) are reported to document their response to radiotheraphy. In three patients there was complete response following radiation treatment, with no local recurrence, whilst the other patient died later with distant metastases. In one patient, post-operative irradiation after excision of an involved local node prevented the growth of further tumour in this nodal group but the unirradiated primary site recurred after initial wide local excision only. This rare tumour appears to be radioresponsive, and although more clinical data are required, we would advocate a wider study of radiotherapy to the primary lesion after biopsy or excision biopsy, in association with prophylactic nodal irradiation. These tumours occur predominantly in elderly people in whom the avoidance of extensive surgery is particularly desirable.
- Published
- 1989
34. Trabecular carcinoma of the skin: a case report
- Author
-
Song W. Wong, Alan D. Glick, and Anh H. Dao
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,business.industry ,Microscopic level ,Tumor cells ,Trabecular carcinoma ,Anatomy ,Adenocarcinoma ,Middle Aged ,medicine.disease ,Pathology and Forensic Medicine ,Metastatic carcinoma ,Lymphoma ,Abdominal wall ,Microscopy, Electron ,medicine.anatomical_structure ,Neuroblastoma ,Medicine ,Humans ,Facial Neoplasms ,business ,Neurosecretory granules - Abstract
A case of trabecular carcinoma of the skin in a 62 year old Caucasian male is reported. The lesions occurred on the face, ear, chest, abdominal wall, and the upper extremity over a period of four years. At the light microscopic level the lesions were confused with metastatic carcinoma, lymphoma, and adult neuroblastoma. Ultrastructural study revealed the presence of not only neurosecretory granules but also premelanosomes in the tumor cells.
- Published
- 1981
35. Merkel cells in the outer follicular sheath
- Author
-
Bauer Ea and Santa Cruz Dj
- Subjects
Pathology ,medicine.medical_specialty ,integumentary system ,Adolescent ,Chemistry ,Root sheath ,Anatomy ,Trabecular carcinoma ,Neuroendocrine tumors ,medicine.disease ,Hair follicle ,Pathology and Forensic Medicine ,medicine.anatomical_structure ,Structural Biology ,Touch ,Follicular phase ,medicine ,Humans ,Female ,Merkel cell ,Epidermolysis Bullosa ,Electron microscopic ,Mechanoreceptors ,Hair ,Skin - Abstract
While performing an electron microscopic examination of the skin for diagnostic purposes, we observed a cluster of cells with dense-core membrane-bound granules in the external root sheath of a hair follicle. The finding of Merkel cells in hair follicle could help to explain some histogenetic features of neuroendocrine tumors of the skin.
- Published
- 1982
36. Trabecular carcinoma of the skin. A question of title
- Author
-
Cyril Toker
- Subjects
Pathology ,medicine.medical_specialty ,Skin Neoplasms ,business.industry ,Terminology as Topic ,medicine ,Humans ,Dermatology ,General Medicine ,Trabecular carcinoma ,Adenocarcinoma ,business ,Pathology and Forensic Medicine - Published
- 1982
37. Trabecular carcinoma of the skin simulating metastatic disease
- Author
-
Miriam Shewach-Millet, Saul Suster, Meyer Ronnen, and Eran Lin
- Subjects
Pathology ,medicine.medical_specialty ,Skin Neoplasms ,medicine.medical_treatment ,Disease ,Adenocarcinoma ,Metastasis ,Neuroblastoma ,Medicine ,Humans ,business.industry ,General Medicine ,Trabecular carcinoma ,Middle Aged ,medicine.disease ,Primary tumor ,medicine.anatomical_structure ,Oncology ,Amputation ,Lymphatic Metastasis ,Surgery ,Female ,Neoplasm Recurrence, Local ,business ,Merkel cell - Abstract
A case of trabecular carcinoma of the skin that resulted in prequarter amputation of the arm for local tumor aggressiveness is presented. The tumor was originally diagnosed as metastatic, most probably neuroblastoma, leading to inadequate local resection that resulted in recurrence with extensive regional nodal metastases. The importance of recognizing trabecular carcinoma as a primary tumor of the skin with a potential for recurrence and metastasis is underscored, primarily since initial total excision with adequate margins of resection has proven in most instances to be curative.
- Published
- 1986
38. Fetoprotein and hepatocarcinogenesis in rats fed 3'-methyl-4-(dimethylamino)azobenzene or N-2-fluorenylacetamide
- Author
-
Taeko Yokochi, Haruo Sugano, and Tomoyuki Kitagawa
- Subjects
Fetal Proteins ,Male ,Cancer Research ,medicine.medical_specialty ,Immunodiffusion ,Mixed type ,Adenocarcinoma ,In Vitro Techniques ,Positive correlation ,p-Dimethylaminoazobenzene ,Sex Factors ,Species Specificity ,Late phase ,Acetamides ,Alpha-Globulins ,medicine ,Animals ,Carbon Isotopes ,Fluorenes ,Dose-Response Relationship, Drug ,Chemistry ,2-Fluorenylacetamide ,Liver Neoplasms ,Age Factors ,Trabecular carcinoma ,Neoplasms, Experimental ,Molecular biology ,Surgery ,Rats ,Oncology ,Liver ,Female ,Precancerous Conditions - Abstract
Serum α-fetoprotein (af) of rats during hepatocarcinogenesis by 3′-methyl-4-(dimethylamino)azobenzene (3′-Me-DAB) or N-2-Fluorenylacetamide (FAA) was checked by the micro-Ouchterlony method throughout the course of the study. The serum af appeared in two phases, early from the 3rd to 5th week and late during the development of large carcinomas. The frequency of early appearance of serum af varied considerably according to the difference in age, sex, and strain of the animals or the difference in type or dose of the carcinogen. In general, 3′-Me-DAB was a much stronger carcinogen than FAA in producing early serum af. A good correlation was observed between the serum af level and the intensity of oval cell proliferation in the liver at this stage. The cell composing the nodular hyperplasia in 3′-Me-DAB or the area of hyperplasia in FAA carcinogenesis, which replaced the major part of the liver in the next stage and had been considered the most possible forerunner of the carcinoma, did not seem to produce af. The serum af in the late phase was produced by the carcinoma. The majority of the 3′-Me-DAB-induced carcinomas belonged to the mixed type carcinoma. This type of carcinoma was strongly af-producing with the required minimal size of 10 mm in diameter for positive serum af. Most of the FAA-induced carcinomas were of the trabecular type. This type of carcinoma was relatively weak in af-production and the serum af was negative until a trabecular carcinoma became larger than 20 mm in diameter. The appearance of early serum af was distinct evidence of a fair progress of hepatocarcinogenesis, and a positive correlation was found between the degree of this phenomenon and the frequency of development of a carcinoma producing large amounts of af. However, the appearance of early serum af was not an absolute requisite for later development of carcinomas. a-Foelig;toproteine et hepatocarcinogenese chez les rats ayant absorbe du 3′-methyl-4-(dimethylamino) azobenzene ou du n-2-fluorenylacetamide L'a-fœoproetine (af) serique des rats a ete etudieee par la methode micro-Ouchterlony tout au long de l'hepatocarcinoginese par le 3′methyl-4- (dimkthylamino) arobenzene (3′-Me-DAB) ou le N-2-fluoreenylacetamide (FAA). L'af serique est apparue en deux stades, soit entre la troiseme et la cinquieme semaine (apparition rapide), soit air stade du developpement d'un gros carcinome (apparition tardive). %%La frequence de l'apparition rapide de l'af serique varie considerablement selon l'ǎge, le sexe et la souche des animaux ou selon le type ou la dose du carcinogene. En general, le 3′-Me-DAB est un carcinogene beaucoup plus puissant que la FAA si l'on considere la production rapide d'af serique. Une correlation nette a ete observee entre le niveau de l'af serique et l'intensite de la proliferation des cellules ovales du foie a ce stade. Les cellules qui composent l'hyperplasie nodulaire dans la carcinogenese par le 3′-Me-DAB, ou la zone hyperplasique dans la carcinogenese par le FAA, qui ont remplace la majeure partie du foie au stade suivant et qui ont ete considerees comme les precurseurs les plus probables du carcinome, ne semblent pas produire d'af. Dans la phase tardive, l'af serique est produite par le carcinome. La majorite des carcinomes induits par le 3′-Me-DAB appartiennent au type mixte. Ce type produit enormement d'af, dont la recherche dans le serum est positive tant que le carcinome n'a pas moins de 10 mm de diametre. La plupart des carcinomes induits par le FAA etaient de type trabeculaire. Ce type produit relativement peu d'af, dont la recherche dans le serum est negative tant que le carcinome n'a pas plus de 20 mm de diametre. L'apparition rapide d'af dans le serum est une preuve nette d'un grand progres de l'hepatocarcinogenese, et une correlation positive a ete constatee entre le degre de ce phenomene et la frequence du developpement d'un carcinome produisant de grandes quantites d'af. Toutefois, l'apparition rapide d'af serique n'est pas un prealable absolu du developpement ulterieur des carcinomes.
- Published
- 1972
39. Trabecular carcinoma is an accurate designation
- Author
-
Carlos Urmacher
- Subjects
Pathology ,medicine.medical_specialty ,Skin Neoplasms ,business.industry ,Terminology as Topic ,Humans ,Medicine ,Dermatology ,General Medicine ,Trabecular carcinoma ,Adenocarcinoma ,business ,Pathology and Forensic Medicine - Published
- 1982
40. Neuroendocrine carcinoma (trabecular carcinoma) of the skin with ectopic ACTH production
- Author
-
H. Iwasaki and Hal G. Bingham
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Ectopic acth ,medicine ,Surgery ,Neuroendocrine carcinoma ,Trabecular carcinoma ,business - Published
- 1982
41. Is Trabecular Carcinoma of the skin a specially differentiated epdidermal Carcinoma?
- Author
-
Marlene Mainitz, Wolfgang Jurecka, and D. Metze
- Subjects
Oncology ,Pathology ,medicine.medical_specialty ,business.industry ,Internal medicine ,Carcinoma ,Medicine ,Dermatology ,General Medicine ,Trabecular carcinoma ,business ,medicine.disease ,Pathology and Forensic Medicine - Published
- 1987
42. Establishment of transplantable hepatomas induced by 3′-methyl – 4 – dimethylaminoazobenzene with special reference to the histologic features of the transplants of early passages
- Author
-
Kihyoe Ichinoe, Charles W. Gibley, and Jeffrey P. Chang
- Subjects
Transplantation ,Pathology ,medicine.medical_specialty ,Air pouch ,Tumor cells ,Trabecular carcinoma ,Biology ,medicine.disease ,Primary tumor ,3 methyl 4 dimethylaminoazobenzene ,medicine ,Adenocarcinoma ,Cortisone ,medicine.drug - Abstract
Summary Several lines of transplantable hepatomas induced by feeding rats 3′-methyl-4-dimethylaminoazobenzene have been established in this laboratory. The primary tumor cells were placed into an air pouch on the back of recipients that were previously conditioned by intramuscular injections of cortisone. This technic is reproducible. If desired, a new transplantable tumor line can be produced almost at will. The resultant transplantable hepatomas which were derived from the two main types of primary tumors, the adenocarcinoma and the trabecular carcinoma, exhibited different biologic behavior and histologic features. Significant morphologic changes occurred in the tumor cells of the first two passages especially if the tumor was of adenocarcinomatous origin. After a few passages these tumors became less differentiated and more stable.
- Published
- 1968
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