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364 results on '"TOBITA, KIMIMASA"'

1. Examining Cesarean Section Rates in Ghana's 10 Regions Over a Decade a Comprehensive National Investigation.

Author

Bosson-Amedenu, Senyefia, Anafo, Abdulzeid, Ouerfelli, Ahmed, Ouerfelli, Nabil, Ouerfelli, Noureddine, and Tobita, Kimimasa

Subjects
CESAREAN section, NATIONAL health services, MATERNAL health services, DEMOGRAPHIC characteristics, EMPIRICAL research, POPULATION geography, DESCRIPTIVE statistics, RETROSPECTIVE studies, HEALTH planning, LONGITUDINAL method, PREECLAMPSIA, HEALTH equity, FETAL distress
Abstract

This study examines cesarean section (C‐section) deliveries in Ghana from 2008 to 2017 in 10 regions, distinguishing between scheduled and emergency procedures. Scheduled C‐sections target specific maternal conditions, such as advanced age, multiparity, and medical history, while emergency C‐sections address acute fetal distress, preeclampsia, bleeding, and other urgent situations. The analysis reveals various regional patterns, with the Brong‐Ahafo Region showing a potential deceleration after 2017 and the Upper West Region indicating a possible acceleration. The high number of C‐sections in Greater Accra and Ashanti may be related to population density and health facilities. The study proposes empirical models, including linear, quadratic, and exponential components, emphasizing quasilinearity. The exponential model suggests transient and permanent phases of cesarean frequency, with the latter dominated by quasilinearity. Optimal parameter values are determined, which highlights the stability of the model. However, caution is advised when projecting too far into the future due to the inevitable slowing of observed trends. The findings offer insights for healthcare planning, resource allocation, and policymaking, emphasizing the need for region‐specific approaches and ongoing monitoring of cesarean dynamics to inform nuanced interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Nasal Anthropometry: An Assessment Among the Akan and Ewe Ethnic Groups in Ghana.

Author

Robertson, Juliet, Abaidoo, Chrissie Stansie, Okwan, Daniel Kobina, Tetteh, Joshua, Adjei-Antwi, Collins, Bempah, Samuel, Ampofo, Michael, and Tobita, Kimimasa

Subjects
NASAL anatomy, CROSS-sectional method, SEX distribution, RHINOPLASTY, JUDGMENT sampling, RESEARCH methodology, ANTHROPOMETRY, COMPARATIVE studies
Abstract

The distribution of nasal types has been reported to be influenced by climatic adaptation as the nose is involved in conditioning inhaled air. Previous studies have reported differential nasal types and dimensions among varying populations which is very beneficial in planning for rhinoplasty and in forensic identification. However, there is inadequate data on nasal types and dimensions of the various ethnic groups in the Ghanaian population. Since it is inappropriate to apply nasal dimensions of one ethnic group to another, the current study sought to assess the nasal types and dimensions of Akans and Ewes in the Ghanaian population. Nasal height, nasal length, nasal tip protrusion, morphological nose width, and anatomical nose width were measured from 202 participants (116 Akans and 86 Ewes) aged 18–27 years belonging to the Akan and Ewe ethnic groups. Nasal index was calculated, and the frequencies of the nasal types among the two ethnic groups were determined. Ewe significantly had greater nasal length and nasal tip protrusion than the Akans. For both ethnic groups, sexual dimorphism was observed in morphological nose width and anatomical nose width, with males having greater values than females. The platyrrhine (broad nose) nasal type was predominant among the Akan and Ewe ethnic groups. The average nasal dimensions of the Akan and Ewe ethnic groups for the Ghanaian population have been reported in the present study, which will be useful in rhinoplasty intended for individuals belonging to these ethnic groups and in identification. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Role of Cilia and Left-Right Patterning in Congenital Heart Disease

Author

Klena, Nikolai, Gabriel, George, Liu, Xiaoqin, Yagi, Hisato, Li, You, Chen, Yu, Zahid, Maliha, Tobita, Kimimasa, Leatherbury, Linda, Pazour, Gregory, Lo, Cecilia W., Nakanishi, Toshio, editor, Markwald, Roger R., editor, Baldwin, H.Scott, editor, Keller, Bradley B., editor, Srivastava, Deepak, editor, and Yamagishi, Hiroyuki, editor

Published
2016
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7. Global genetic analysis in mice unveils central role for cilia in congenital heart disease

Author

Li, You, Klena, Nikolai T., Gabriel, George C., Liu, Xiaoqin, Kim, Andrew J., Lemke, Kristi, Chen, Yu, Chatterjee, Bishwanath, Devine, William, Damerla, Rama Rao, Chang, Chienfu, Yagi, Hisato, Agustin, Jovenal T. San, Thahir, Mohamed, Anderton, Shane, Lawhead, Caroline, Vescovi, Anita, Pratt, Herbert, Morgan, Judy, Haynes, Leslie, Smith, Cynthia L., Eppig, Janan T., Reinholdt, Laura, Francis, Richard, Leatherbury, Linda, Ganapathiraju, Madhavi K., Tobita, Kimimasa, Pazour, Gregory J., and Lo, Cecilia W.

Subjects
Congenital heart disease -- Genetic aspects -- Research, Cilia and ciliary motion -- Genetic aspects -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation, University of Pittsburgh. School of Medicine
Abstract

Congenital heart disease (CHD) is the most prevalent birth defect, affecting nearly 1% of live births (1); the incidence of CHD is up to tenfold higher in human fetuses (2,3). A genetic contribution is strongly suggested by the association of CHD with chromosome abnormalities and high recurrence risk4. Here we report findings from a recessive forward genetic screen in fetal mice, showing that cilia and cilia-transduced cell signalling have important roles in the pathogenesis of CHD. The cilium is an evolutionarily conserved organelle projecting from the cell surface with essential roles in diverse cellular processes. Using echocardiography, we ultrasound scanned 87,355 chemically mutagenized C57BL/6J fetal mice and recovered 218 CHD mouse models. Whole-exome sequencing identified 91 recessive CHD mutations in 61 genes. This included 34 cilia-related genes, 16 genes involved in cilia-transduced cell signalling, and 10 genes regulating vesicular trafficking, a pathway important for ciliogenesis and cell signalling. Surprisingly, many CHD genes encoded interacting proteins, suggesting that an interactome protein network may provide a larger genomic context for CHD pathogenesis. These findings provide novel insights into the potential Mendelian genetic contribution to CHD in the fetal population, a segment of the human population not well studied. We note that the pathways identified show overlap with CHD candidate genes recovered in CHD patients5, suggesting that they may have relevance to the more complex genetics of CHD overall. These CHD mouse models and >8,000 incidental mutations have been sperm archived, creating a rich public resource for human disease modelling., Inbred C57BL/6J mice mutagenized with ethylnitrosourea (ENU) were bred to recover recessive coding mutations (Extended Data Fig. 1). Phenotyping was conducted using non-invasive fetal echocardiography, an ultrasound imaging modality also [...]

Published
2015

20. Modest maternal caffeine exposure affects developing embryonic cardiovascular function and growth

Author

Momoi, Nobuo, Tinney, Joseph P., Liu, Li J., Elshershari, Huda, Hoffmann, Paul J., Ralphe, John C., Keller, Bradley B., and Tobita, Kimimasa

Subjects
Pregnancy -- Physiological aspects, Caffeine -- Influence, Caffeine -- Physiological aspects, Cardiovascular system -- Research, Carotid artery -- Growth, Cell receptors -- Properties, Embryo -- Growth, Company growth, Biological sciences
Abstract

Caffeine consumption during pregnancy is reported to increase the risk of in utero growth restriction and spontaneous abortion. In the present study, we tested the hypothesis that modest maternal caffeine exposure affects in utero developing embryonic cardiovascular (CV) function and growth without altering maternal hemodynamics. Caffeine (10 mg.[kg.sup-1].[day.sup.-1] subcutaneous) was administered daily to pregnant CD-1 mice from embryonic days (EDs) 9.5 to 18.5 of a 21-day gestation. We assessed maternal and embryonic CV function at baseline and at peak maternal serum caffeine concentration using high-resolution echocardiography on EDs 9.5, 11.5, 13.5, and 18.5. Maternal caffeine exposure did not influence maternal body weight gain, maternal CV function, or embryo resorption. However, crown-rump length and body weight were reduced in maternal caffeine treated embryos by ED 18.5 (P < 0.05). At peak maternal serum caffeine concentration, embryonic carotid artery, dorsal aorta, and umbilical artery flows transiently decreased from baseline at ED 11.5 (P < 0.05). By ED 13.5, embryonic aortic and umbilical artery flows were insensitive to the peak maternal caffeine concentration; however, the carotid artery flow remained affected. By ED 18.5, baseline embryonic carotid artery flow increased and descending aortic flow decreased versus non-caffeine-exposed embryos. Maternal treatment with the adenosine [A.sub.2A] receptor inhibitor reproduced the embryonic hemodynamic effects of maternal caffeine exposure. Adenosine [A.sub.2A] receptor gene expression levels of ED 11.5 embryo and ED 18.5 uterus were decreased. Results suggest that modest maternal caffeine exposure has adverse effects on developing embryonic CV function and growth, possibly mediated via adenosine [A.sub.2A] receptor blockade. adenosine [A.sub.2A] receptor; cardiovascular development; carotid artery; pregnancy

Published
2008

23. Contributors

Author

Abbas, Sami, primary, AbouLaila, Mahmoud, additional, Acquas, Elio, additional, Adhikary, Biplab, additional, Afzal, M., additional, Agrogiannis, George, additional, Ahmed, Selena, additional, Alao, John P., additional, Almeida, Cristina M.M., additional, Amin, A.R.M. Ruhul, additional, Andrade, J.P., additional, Aruoma, Okezie I., additional, Asaumi, Hiroshi, additional, Assunção, Marco, additional, Augustyniak, Agnieszka, additional, Babcock, George F., additional, Babich, Harvey, additional, Bahorun, Theeshan, additional, Bajerska, Joanna, additional, Baldermann, Susanne, additional, Bandyopadhyay, Sandip Kumar, additional, Banerjee, Shuvojit, additional, Basu, Arpita, additional, Bettuzzi, Saverio, additional, Bhattacharya, Udayan, additional, Bhattacharyya, Anjan, additional, Bhattacharyya, Jharna, additional, Pathy, Nirmala Bhoo, additional, Bigelow, Rebecca L., additional, Bouglé, Dominique, additional, Brighenti, Furio, additional, Bun, Sok-Siya, additional, Byun, Eui-Hong, additional, Calani, Luca, additional, Cardelli, James A., additional, Chalo, R., additional, Chan, Laura, additional, Chan B.sc., Ruth, additional, Chan, Tak Hang, additional, Chang, Hsin-Huei, additional, Chang, Kuang-Hua, additional, Chuen-Chung Chang, Raymond, additional, Charalampos, Proestos, additional, Chatterjee, Indu Bhushan, additional, Chattopadhyay, Subrata, additional, Chen, Chung-Yu, additional, Chen, Di, additional, Chen, Haixia, additional, Hong-Duo, Chen, additional, Chen, Junping, additional, Chen, Po-Chung, additional, Chen, Richie L.C., additional, Chen, Xiaoqiang, additional, Cheng, Tzong-Jih, additional, Chu, Kai On, additional, Chyu, Ming-Chien, additional, Cimpoiu, Claudia, additional, Cuzzocrea, Salvatore, additional, Das, Asankur Sekhar, additional, Das, Dolan, additional, Das, Kaushik, additional, Bruin, Eveline A. de, additional, De Mejia, Elvira, additional, Dejaegher, Bieke, additional, Delaney, Sarah, additional, Dou, Jianpeng, additional, Dou, Q. Ping, additional, Dworakowska, Dorota, additional, Eckhoff, Rachel, additional, Egawa, Tatsuro, additional, Einother, Suzanne, additional, Elango, Ramesh, additional, Elias, Riad, additional, El-Sayed, Nesrine Salah EL-Dine, additional, Feng, Lei, additional, Feng, Wan Yong, additional, Fenu, Sandro, additional, Ferreres, Federico, additional, Figueira, Maria E., additional, Fix, Lindsey N., additional, Frazier, Richard A., additional, Frezza, Michael, additional, Gao, Xing-Hua, additional, García-Viguera, Cristina, additional, Gehrke, Sarah A., additional, Geraldine, Pitchairaj, additional, Ghosh, Arunava, additional, Giesbrecht, Timo, additional, Giunta, Brian, additional, Gil, José Ignacio, additional, Gil-Izquierdo, Angel, additional, Giri, Ashok K., additional, Gleichenhagen, Maike, additional, Grant, Paul S., additional, Gyamfi, Daniel, additional, Hamada, Taku, additional, Haque, Md Abdul, additional, Hara, Yukihiro, additional, Hashimoto, Michio, additional, Hayashi, Nobuyuki, additional, Hayashi, Tstauya, additional, He, Rong-Rong, additional, Heber, David, additional, Henning, Susanne M., additional, Hirata, Yasunobu, additional, Yuen-Shan Ho, Ku, additional, Hosu, Anamaria, additional, Houghton, Jean Marie, additional, Hsiao, Hsien-Yi, additional, Hsieh, Bo-Chuan, additional, Huang, Chun-Hsiung, additional, Huang, Dejian, additional, Hiu-Ling Hung, Clara, additional, Hung, Yueh-Tzu, additional, Hwang, Daniel H., additional, Hyun-Gyun, Yuk, additional, Igarashi, Ikuo, additional, Isobe, Mitsuaki, additional, Jasienska, Grazyna, additional, Jeszka, Jan, additional, Ji, Seon Kim, additional, Jianrong, Li, additional, Jin, Heiying, additional, Jing, Yali, additional, Jinz, Heiying, additional, Jordan, Susan, additional, Jundoria, Arvin, additional, Kalinovsky, Tatiana, additional, Kamunya, S., additional, Kanno, Yoshihiko, additional, Kanrar, Bappaditya, additional, Kao, Yung-Hsi, additional, Kapetanovic, Izet M., additional, Kapiszewska, Maria, additional, Kapsokefalou, Maria, additional, Kavantzas, Nikolaos, additional, Keller, Bradley B., additional, Kerio, Lilian C., additional, Khan, Sara Anees, additional, Kim, Jong-Min, additional, Kojima-Yuasa, Akiko, additional, Kokotkiewicz, Adam, additional, Komaitis, Michael, additional, Kottur, Govindasamy, additional, Koutelidakis, Antonios E., additional, Ku, Hui-Chen, additional, Kua, Ee-Heok, additional, Kuhnert, Nikolai, additional, Kuo, Yow-Chii, additional, Kurihara, Hiroshi, additional, Kuriyama, Shinichi, additional, Lanzett, Manuella, additional, Le, Anh D., additional, Lee, Andy H., additional, Lee, Joo Young, additional, Lee, Maw-Rong, additional, Lee, Ren-Jye, additional, Lee, Seung-Cheol, additional, Lee, Viola S.Y., additional, Li, Na-Na, additional, Li, Wei, additional, Li, Yuan-Hong, additional, Liang, Yue-Rong, additional, Lin, Chih-Ming, additional, Lin, Ching-Ling, additional, Liu, Chi-Wei, additional, Liu, Hang-Seng, additional, Liu, Pengxin, additional, Longoni, Rosanna, additional, Lorenz, Mario, additional, Lu, Jian-Liang, additional, Lu, Ya-Ning, additional, Lucas, Edralin A., additional, Łuczaj, Wojciech, additional, Luczkiewicz, Maria, additional, Luximon-Ramma, Amitabye, additional, Lynch, Paul, additional, Lyons, Timothy J., additional, Ma, Xiao, additional, Maeda-Yamamoto, Mari, additional, Mahungu, Symon M., additional, Makabe, Hidefumi, additional, Mao, Jenny T., additional, Mariga, Irvine K., additional, Maritim, T., additional, Martin, Colin R., additional, Masuda, Shuichi, additional, Matsui-Yuasa, Isao, additional, Mbuthia, Stephen Karori, additional, Medina, Sonia, additional, Mehra, Aradhana, additional, Melzig, Matthias F., additional, Merklinger-Gruchala, Anna, additional, Meydani, Mohsen, additional, Miclaus, Vasile, additional, Mitra, Chandan, additional, Miyamoto, Yohei, additional, Momoi, Nobuo, additional, Mousa, S.A., additional, Mudau, Fhatuwani Nixwell, additional, Mujtaba, Taskeen, additional, Mumy, Karen L., additional, Murakami, Akira, additional, Murase, Takatoshi, additional, Murugan, Ramalingam Senthil, additional, Murugesan, Subramanian, additional, Nagai, Ryozo, additional, Nagini, Siddavaram, additional, Nagle, Christina, additional, Nakajima, Kei, additional, Neergheen-Bhujun, Vidushi, additional, Ng, Tze-Pin, additional, Ngure, Francis Muigai, additional, Niedzwiecki, Aleksandra, additional, Niu, Kaijun, additional, Nomani, M., additional, O'Brien, Peter, additional, Ogawa, Masahito, additional, Oh, Eung Seok, additional, Okamoto, Kazushi, additional, Ollivier, Evelyne, additional, Osterburg, Andrew R., additional, Otsuki, Makoto, additional, Pang, Chi Pui, additional, Pasalich, Maria, additional, Paterniti, Irene, additional, Patsouris, Efstratios, additional, Persson, Ingrid A.-L., additional, Piljac, Ante, additional, Piljac-Zegarac, Jasenka, additional, Porto, Luís Cristóvão, additional, Prendergast, Mark A., additional, Pripdeevech, Patcharee, additional, Priyamvada, Shubha, additional, Puangpraphant, Sirima, additional, Senthil Kumar, Ramasamy Shanmugasundaram, additional, M., Gregory Raner, additional, Rath, Matthias, additional, Del Rio, Daniele, additional, Rizk, Sherine M., additional, Rizzi, Federica, additional, Robinson, Randy J., additional, Rodrigues, Jorge, additional, Roomi, M. Waheed, additional, Ross, Colleen Margaret, additional, Safer, Abdel-Majeed A., additional, Saikat, Sohel, additional, Sama, Andrew E., additional, Šamec, Dunja, additional, Sameshima, Yoichi, additional, Schuck, Alyssa G., additional, Seong, Baik-Lin, additional, Sharma, Anubha, additional, Shen, Chwan-Li, additional, Sheu, Joen-Rong, additional, Shih, Li-Jane, additional, Shimamura, Yuko, additional, Shin, Dong Moon, additional, Shitandi, Anakalo A., additional, Skrzydlewska, Elżbieta, additional, Smith, Thomas J., additional, Somanah, Jhoti, additional, Song, Jae-Min, additional, Spina, Liliana, additional, Stepp, John Richard, additional, Stoicov, Calin, additional, Sun, Guang-Huan, additional, Suzuki, Jun-ichi, additional, Tachibana, Hirofumi, additional, Tan, Jun, additional, Tang, Nelson L.S., additional, Tang, Xudong, additional, Theodore, Joseph, additional, Thomas, Philip A., additional, Tobita, Kimimasa, additional, Toolsee, Naushad A., additional, Tzen, Jason T.C., additional, Uiterwaal, Cuno S.P.M., additional, Valenca, Samuel Santos, additional, van Buren, Leo, additional, Butler, Tracy R., additional, van der Pijl, Pieter C., additional, Heyden, Yvan Vander, additional, Vignes, Michel, additional, Vinci, Stefania, additional, Wachira, Francis, additional, Walden, Charlotte M., additional, Wan, Luke, additional, Wang, Chi Chiu, additional, Wang, Haichao, additional, Wang, Piwen, additional, Wanyoko, J.K., additional, Watanabe, Naoharu, additional, Weisburg, Jeffrey H., additional, Weiss, David J., additional, Weng, Jueng-Tsueng, additional, Wink, Michael, additional, Chian Wong, Adeline Ik, additional, Wongpornchai, Sugunya, additional, Woo, Jean, additional, Wozniewicz, Malgorzata, additional, Wu, Bo-Tsung, additional, Wu, Yan, additional, Xiaoqiang, Chen, additional, Yadav, Sudhir Kumar, additional, Yamada, Hiroshi, additional, Yang, Ya Ping, additional, Yang, Ziyin, additional, Chien-Chih, Yeh, additional, Yu, Hyun-Gyun, additional, Yusufi, Ahad N.K., additional, Zahreldin, Ahmad A., additional, Zhang, Hongzheng, additional, Zhang, Liang, additional, Zhang, Baohong, additional, Zhang, Bei, additional, Zhang, Chunxia, additional, Zhang, Jing-Song, additional, Zhang, Lan, additional, Zhang, Li, additional, Zhang, Qunzhou, additional, Zhang, Zheng-Zhu, additional, Zhao, Ling, additional, Zhou, Keyuan, additional, Zhou, Limin, additional, Zhu, Dalong, additional, Zhu, Shu, additional, Zimmermann, Benno F., additional, Zingg, Jean-Marc, additional, Zuckerbraun, Harriet L., additional, and Zuo, Zhong, additional

Published
2013
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25. Engineered early embryonic cardiac tissue retains proliferative and contractile properties of developing embryonic myocardium

Author

Tobita, Kimimasa, Liu, Li J., Janczewski, Andrzej M., Tinney, Joseph P., Nonemaker, Jill M., Augustine, Serena, Stolz, Donna B., Shroff, Sanjeev G., and Keller, Bradley B.

Subjects
Heart muscle -- Genetic aspects, Heart muscle -- Physiological aspects, Cell proliferation -- Research, Hyperplasia -- Physiological aspects, Biological sciences
Abstract

Embryonic myocardium has a high rate of cell proliferation and regulates cellular proliferation, contractile function, and myocardial architecture in response to changes in external mechanical loads. However, the small and complex three-dimensional (3D) structure of the embryonic myocardium limits our ability to directly investigate detailed relationships between mechanical load, contractile function, and cardiomyocyte proliferation. We developed a novel 3D engineered early embryonic cardiac tissue (EEECT) from early embryonic ventricular cells to test the hypothesis that EEECT retains the proliferative and contractile properties of embryonic myocardium. We combined freshly isolated White Leghorn chicken embryonic ventricular cells at Hamburger-Hamilton (HH) stage 31 (day 7 of a 46-stage, 21-day incubation period), collagen type I, and matrix factors to construct cylindrical-shaped EEECTs. We studied tissue architecture, cell proliferation patterns, and contractile function. We then generated engineered fetal cardiac tissue (EFCT) from HH stage 40 (day 14) fetal ventricular cells for direct comparison with EEECT. Tissue architecture was similar in EEECT and EFCT. EEECT maintained high cell proliferation patterns by culture day 12, whereas EFCT decreased cell proliferation rate by culture day 9 (P < 0.05). EEECT increased active contractile force from culture day 7 to day 12. The culture day 12 EEECT contractile response to the [beta]-adrenergic stimulation was less than culture day 9 EFCT (P < 0.05). Cyclic mechanical stretch stimulation induced myocardial hyperplasia in EEECT. Results indicate that EEECT retains the proliferative and contractile properties of developing embryonic myocardium and shows potential as a robust in vitro model of developing embryonic myocardium. cardiomyocyte; morphogenesis; growth and development; hyperplasia; tissue engineering

Published
2006

26. Regional passive ventricular stress-strain relations during development of altered loads in chick embryo

Author

Tobita, Kimimasa, Schroder, Elizabeth A., Tinney, Joseph P., Garrison, Jason B., and Keller, Bradley B.

Subjects
Physiology -- Research, Heart ventricles -- Research, Morphogenesis -- Research, Biological sciences
Abstract

Mechanical load influences embryonic ventricular growth, morphogenesis, and function. However, little is known about changes in regional passive ventricular properties during the development of altered mechanical loading conditions in the embryo. We tested the hypothesis that regional mechanical loads are a critical determinant of embryonic ventricular passive properties. We measured biaxial passive right and left ventricular (RV and LV, respectively) stress-strain relations in chick embryos at Hamburger-Hamilton stages 21 and 27 after conotruncal banding (CTB) to increase biventricular pressure load or left atrial ligation (LAL) to reduce LV volume load and increase RV volume load. In the RV, wall strains at end-diastolic (ED) pressure normalized whereas ED stresses increased after either CTB or LAL during development. In the left ventricle, both ED strain and stress normalized after CTB, whereas both remained reduced with significantly increased myocardial stiffness after LAL. These results suggest that the embryonic ventricle adapts to chronically altered mechanical loading conditions by changing specific RV and LV passive properties. Thus regional mechanical load has a critical role during cardiogenesis. ventricle; cardiac morphogenesis; mechanical load

Published
2002

32. Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells

Author

Takeishi, Kazuki, primary, Collin de l’Hortet, Alexandra, additional, Wang, Yang, additional, Handa, Kan, additional, Guzman-Lepe, Jorge, additional, Matsubara, Kentaro, additional, Morita, Kazutoyo, additional, Jang, Sae, additional, Haep, Nils, additional, Florentino, Rodrigo M., additional, Yuan, Fangchao, additional, Fukumitsu, Ken, additional, Tobita, Kimimasa, additional, Sun, Wendell, additional, Franks, Jonathan, additional, Delgado, Evan R., additional, Shapiro, Erik M., additional, Fraunhoffer, Nicolas A., additional, Duncan, Andrew W., additional, Yagi, Hiroshi, additional, Mashimo, Tomoji, additional, Fox, Ira J., additional, and Soto-Gutierrez, Alejandro, additional

Published
2020
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35. Induction and Patterning of the Impulse Conducting Purkinje Fiber Network

Author

Mikawa, Takashi, primary, Gourdie, Robert G., additional, Poma, Clifton P., additional, Shulimovich, Maxim, additional, Hall, Christopher, additional, Hewett, Kenneth W., additional, Justus, Chip, additional, Reckova, Maria, additional, Sedmera, David, additional, Tobita, Kimimasa, additional, Hurtado, Romulo, additional, Pennisi, David J., additional, Kanzawa, Nobuyuki, additional, and Takebayashi-Suzuki, Kimiko, additional

Published
2007
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37. End-systolic myocardial stiffness is a load-independent index of contractility in stage 24 chick embryonic heart

Author

Tobita, Kimimasa and Keller, Bradley B.

Subjects
Chicks -- Physiological aspects, Heart -- Contraction, Cardiovascular system -- Physiological aspects, Biological sciences
Abstract

Research was conducted to examine the effects of acute alteration of loading condition to chick embryonic ventricular contractility using end-systolic myocardial stiffness based on the incremental elastic modulus concept. The embryonic end-systolic pressure-volume relations and maximum systolic stiffness were investigated during acute changes in ventricular preload, afterload and myofilament activation. Results indicate that normalized end-systolic myocardial stiffness is a load-independent index of ventricular contractility in the developing embryonic chick ventricle.

Published
1999

47. A Novel System for Spinal Muscular Atrophy Screening in Newborns: Japanese Pilot Study

Author

Shinohara, Masakazu, primary, Niba, Emma Tabe Eko, additional, Wijaya, Yogik Onky Silvana, additional, Takayama, Izumi, additional, Mitsuishi, Chisako, additional, Kumasaka, Sakae, additional, Kondo, Yoichi, additional, Takatera, Akihiro, additional, Hokuto, Isamu, additional, Morioka, Ichiro, additional, Ogiwara, Kazutaka, additional, Tobita, Kimimasa, additional, Takeuchi, Atsuko, additional, and Nishio, Hisahide, additional

Published
2019
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49. Efficacy and safety of alirocumab in patients with hypercholesterolemia not adequately controlled with non-statin lipid-lowering therapy or the lowest strength of statin : ODYSSEY NIPPON study design and rationale

Author

Teramoto, Tamio, Kondo, Akira, Kiyosue, Arihiro, Harada-Shiba, Mariko, Ishigaki, Yasushi, Tobita, Kimimasa, Kawabata, Yumiko, Ozaki, Asuka, Baccara-Dinet, Marie T., Sata, Masataka, Teramoto, Tamio, Kondo, Akira, Kiyosue, Arihiro, Harada-Shiba, Mariko, Ishigaki, Yasushi, Tobita, Kimimasa, Kawabata, Yumiko, Ozaki, Asuka, Baccara-Dinet, Marie T., and Sata, Masataka

Abstract

Background: Statins are generally well-tolerated and serious side effects are infrequent, but some patients experience adverse events and reduce their statin dose or discontinue treatment altogether. Alirocumab is a highly specific, fully human monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), which can produce substantial and sustained reductions of low-density lipoprotein cholesterol (LDL-C). Methods: The randomized, double-blind, placebo-controlled, parallel-group, phase 3 ODYSSEY NIPPON study will explore alirocumab 150 mg every 4 weeks (Q4W) in 163 Japanese patients with hypercholesterolemia who are on the lowest-strength dose of atorvastatin (5 mg/day) or are receiving a non-statin lipid-lowering therapy (LLT) (fenofibrate, bezafibrate, ezetimibe, or diet therapy alone). Hypercholesterolemia is defined as LDL-C ≥ 100 mg/dL (2.6 mmol/L) in patients with heterozygous familial hypercholesterolemia or non-familial hypercholesterolemia with a history of documented coronary heart disease, or ≥120 mg/dL (3.1 mmol/L) in patients with non-familial hypercholesterolemia classified as primary prevention category III (i.e. high-risk patients). During the 12-week double-blind treatment period, patients will be randomized (1:1:1) to receive alirocumab subcutaneously (SC) 150 mg Q4W alternating with placebo for alirocumab Q4W, or alirocumab 150 mg SC every 2 weeks (Q2W), or SC placebo Q2W. The primary efficacy endpoint is the percentage change in calculated LDL-C from baseline to week 12. The long-term safety and tolerability of alirocumab will also be investigated. Discussion: The ODYSSEY NIPPON study will provide insights into the efficacy and safety of alirocumab 150 mg Q4W or 150 mg Q2W among Japanese patients with hypercholesterolemia who are on the lowest-strength dose of atorvastatin, or are receiving a non-statin LLT (including diet therapy alone).

Published
2017

50. Efficacy and safety of alirocumab in patients with hypercholesterolemia not adequately controlled with non-statin lipid-lowering therapy or the lowest strength of statin: ODYSSEY NIPPON study design and rationale

Author

Teramoto, Tamio, primary, Kondo, Akira, additional, Kiyosue, Arihiro, additional, Harada-Shiba, Mariko, additional, Ishigaki, Yasushi, additional, Tobita, Kimimasa, additional, Kawabata, Yumiko, additional, Ozaki, Asuka, additional, Baccara-Dinet, Marie T., additional, and Sata, Masataka, additional

Published
2017
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