1. Regulation of B Versus T Lymphoid Lineage Fate Decision by the Proto-Oncogene LRF
- Author
-
Giorgio Cattoretti, Takahiro Maeda, Taha Merghoub, Koichi Akashi, Pier Paolo Pandolfi, Hirokazu Shigematsu, Marcel R.M. van den Brink, Arthur Zelent, Julie Teruya-Feldstein, Manami Maeda, Lin Dong, Robin M. Hobbs, Johannes L. Zakrzewski, Maeda, T, Merghoub, T, Hobbs, R, Dong, L, Maeda, M, Zakrzewski, J, van den Brink, M, Zelent, A, Shigematsu, H, Akashi, K, Teruya Feldstein, J, Cattoretti, G, and Pandolfi, P
- Subjects
T-Lymphocytes ,Cellular differentiation ,ProtoOncogenes ,Receptors, Notch/*metabolism ,Models, Biological ,Mice ,Bone Marrow Cells/cytology ,Cell Lineage ,Mice, Inbred C57BL ,Cells, Cultured ,Mice, Knockout ,B-Lymphocytes ,Multidisciplinary ,Receptors, Notch ,Lymphopoiesis ,Transcription Factors/*genetics/physiology ,Cell biology ,DNA-Binding Proteins ,Haematopoiesis ,medicine.anatomical_structure ,Stem cell ,BLymphocytes/*cytology/physiology ,Signal Transduction ,Lineage (genetic) ,Bone Marrow Cells ,Thymus Gland ,Biology ,Proto-Oncogenes ,medicine ,Animals ,Thymus Gland/cytology ,Transcription factor ,DNABinding Proteins/*genetics/physiology ,T lymphocyte ,Gene Deletion ,Hematopoietic Stem Cells ,Immunology ,Bone marrow ,Hematopoietic Stem Cells/*cytology/physiology ,TLymphocytes/*cytology/physiology ,Transcription Factors - Abstract
Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop into B lineage cells by repressing T cell–instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.
- Published
- 2007
- Full Text
- View/download PDF