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Your search keyword '"TAKI, NAOYUKI"' showing total 16 results
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16 results on '"TAKI, NAOYUKI"'

1. Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice

Author

Okubo, Hirofumi, Kushiyama, Akifumi, Sakoda, Hideyuki, Nakatsu, Yusuke, Iizuka, Masaki, Taki, Naoyuki, Fujishiro, Midori, Fukushima, Toshiaki, Kamata, Hideaki, Nagamachi, Akiko, Inaba, Toshiya, Nishimura, Fusanori, Katagiri, Hideki, Asahara, Takashi, Yoshida, Yasuto, Chonan, Osamu, Encinas, Jeffery, and Asano, Tomoichiro

Published
2016
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5. Resistin-Like Molecule β Is Abundantly Expressed in Foam Cells and Is Involved in Atherosclerosis Development

Author

Kushiyama, Akifumi, primary, Sakoda, Hideyuki, additional, Oue, Naohide, additional, Okubo, Masamichi, additional, Nakatsu, Yusuke, additional, Ono, Haruya, additional, Fukushima, Toshiaki, additional, Kamata, Hideaki, additional, Nishimura, Fusanori, additional, Kikuchi, Takako, additional, Fujishiro, Midori, additional, Nishiyama, Koichi, additional, Aburatani, Hiroyuki, additional, Kushiyama, Sakura, additional, Iizuka, Masaki, additional, Taki, Naoyuki, additional, Encinas, Jeffrey, additional, Sentani, Kazuhiro, additional, Ogonuki, Narumi, additional, Ogura, Atsuo, additional, Kawazu, Shoji, additional, Yasui, Wataru, additional, Higashi, Yukihito, additional, Kurihara, Hiroki, additional, Katagiri, Hideki, additional, and Asano, Tomoichiro, additional

Published
2013
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16. [Reserpine-induced supersensitivity and alpha 1-adrenoceptor subtypes].

Author

Muramatsu I, Taki N, Zhang L, Israilova M, Hiraizumi Y, Morishima S, Suzuki F, and Tanaka T

Subjects
Animals, Aorta, Thoracic drug effects, Rats, Tail blood supply, Arteries drug effects, Drug Tolerance physiology, Receptors, Adrenergic, alpha-1 physiology, Reserpine pharmacology
Abstract

Supersensitivity is one of classical and pharmacological phenomena, and may be caused by a variety of procedures, including surgical and chemical denervation and chronic treatment with antagonists. We examined reserpine-induced chemical denervation supersensitivity with special reference to arterial alpha 1-adrenoceptor (alpha 1-AR) subtypes. Chronic treatment with reserpine for 2 weeks produced supersensitivity in the contractile response to phenylephrine of isolated rat tail artery, resulting a leftward shift of concentration-response curve (10 fold shift at EC50 value). This supersensitivity in reserpine-treated artery was selectively inhibited by BMY7378 (alpha 1D-AR selective antagonist) but not by KMD-3213 (alpha 1A-AR selective antagonist). On the other hand, the response to phenylephrine in reserpine-untreated artery was inhibited by KMD-3213 but not by BMY7378. Tissue segment binding study with 3H-prazosin revealed that high affinity binding sites for BMY7378 were detected with a proportion of 32% in reserpine-treated tail artery but absent in untreated artery, although total density of alpha 1-ARs was not changed by reserpine-treatment. The present results strongly suggest that reserpine-induced supersensitivity of rat tail artery is caused by a selective induction of alpha 1D-AR subtype.

Published
2003

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