1. Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review
- Author
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Jessica Bauer, Yasna Jain, Taher A. Saif, Barbara Jung, and Bashar Emon
- Subjects
0301 basic medicine ,EMT, Epithelial to mesenchymal transition ,VEGF, Vascular endothelial growth factor ,TACs, Tumor-associated collagen signatures ,IGFs, Insulin-like growth factors ,IL-13, Interleukin-13 ,Review Article ,LOX, Lysyl Oxidase ,Biochemistry ,Metastasis ,SDF-1/CXCL12, Stromal cell-derived factor 1/C-X-C motif chemokine 12 ,Extracellular matrix ,α-SMA, α-Smooth muscle actin ,0302 clinical medicine ,Structural Biology ,TNF-α, Tumor necrosis factor-α ,HGF/SF, Hepatocyte growth factor/Scatter factor ,Cancer ,CSF-1, Colony stimulating factor 1 ,MMPs, Matrix metalloproteinases ,3. Good health ,Computer Science Applications ,Tumor biophysics ,EGF, Epidermal growth factor ,030220 oncology & carcinogenesis ,CAF, Cancer associated fibroblast ,ECM stiffness ,Growth factors ,Biotechnology ,Stromal cell ,KGF, Keratinocyte growth factor, also FGF7 ,lcsh:Biotechnology ,CYR61/CCN1, Cysteine-rich angiogenic inducer 61/CCN family member 1 ,Biophysics ,Cancer metastasis ,NO, Nitric oxide ,03 medical and health sciences ,ECM, Extracellular matrix ,IL-33, Interleukin-33 ,Stroma ,lcsh:TP248.13-248.65 ,TGFβ, Transforming growth factor β ,Genetics ,medicine ,IL-6, Interleukin-6 ,Tumor microenvironment ,business.industry ,technology, industry, and agriculture ,medicine.disease ,Activin/TGFβ ,030104 developmental biology ,ADAMs, Adamalysins ,CTGF, Connective tissue growth factor ,Cancer cell ,Cancer research ,ANGPT2, Angiopoietin 2 ,business ,FGF, Fibroblast growth factor - Abstract
The role of tumor microenvironment in cancer progression is gaining significant attention. It is realized that cancer cells and the corresponding stroma co-evolve with time. Cancer cells recruit and transform the stromal cells, which in turn remodel the extra cellular matrix of the stroma. This complex interaction between the stroma and the cancer cells results in a dynamic feed-forward/feed-back loop with biochemical and biophysical cues that assist metastatic transition of the cancer cells. Although biochemistry has long been studied for the understanding of cancer progression, biophysical signaling is emerging as a critical paradigm determining cancer metastasis. In this mini review, we discuss the role of one of the biophysical cues, mostly the mechanical stiffness of tumor microenvironment, in cancer progression and its clinical implications., Graphical abstract Unlabelled Image
- Published
- 2018
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