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There has been an increase the prevalence of andrological diseases in all age groups in recent decades, including those with comorbid conditions such as pathology of the cardiovascular system and liver, which are manifestations of metabolic syndrome. Research aim: to investigate the relationship between formation of hepatic steatosis and hypoandrogenism (HA) in adolescent boys. Materials and methods. The study involved 42 adolescent boys aged 14–18 years with laboratory confirmed HA in whom total testosterone levels were less than 12.0 nmol/l. Sex hormones, gonadotropins, insulin levels, biochemical parameters of liver function, the state of free radical oxidation and antioxidant protection were determined in patients. Based on ultrasound examination adolescents with HA were divided into 2 groups: group 1 – 15 adolescents with signs of liver steatosis; group 2 – 27 adolescents with normal ultrasound parameters of a liver. The control group consisted of 38 boys of the same age with normal indicators of physical and sexual development without signs of pathology of the hepatobiliary system. Results. Individual assessment of sexual development allowed to diagnose I degree of delayed sexual development in 44.7%, II degree in 38.3% and III degree in 17.0% of adolescents. HA negatively affects the physical development of most boys (78.7%), due to short stature (40.0%), weight deficiency (20.0%) and overweight (18.7%). Factor analysis allowed to build a factor model of hepatic steatosis formation in adolescents with delayed sexual development and HA, which describes 76.0% of the sample and consists of five factors. Conclusion. Atherogenic changes of the lipid profile, androgen deficiency, insulin resistance, activation of cytolytic processes in the liver and oxidative stress formation due to a decrease in the effectiveness of antioxidant protection are important in the pathogenesis of hepatic steatosis in boys with HA. A factor model of the hepatic steatosis development in adolescent boys with HA gives grounds for the development of therapeutic and preventive measures in adolescent boys with HA and comorbid liver pathology.

Background. To improve the prevention of the development and progression of psychosomatic diseases, psychological deviations in school-age children from the zone of military conflict was the purpose of our study. Materials and methods. A clinical and paraclinical survey was performed in 286 schoolchildren living in Donetsk and Luhansk regions, and immigrants from these places. Cardiointervalography was use to determine stress levels, followed by analysis of heart rate variability. Psychological features were study using following techniques: a multidimensional assessment of children’s anxiety, the internal picture of health, Lüscher test. The intensity of the stress-regulating systems was evaluated taking into account the indicators of cortisol, adrenaline, norepinephrine, lipid peroxidation products, serotonin, melatonin, reduced glutathione, glutathione peroxidase and superoxide dismutase activity. Results. The paper presents the features of the health status of children, the nature of psychological deviations, taking into account the level of psycoemotional stress. Data on the imbalance of stress-regulating system indicators are presented. Suggestions for medical and psychological support of these patients are given. Conclusions. Most children from the conflict zone have an increased level of emotional stress, which provokes the activation of stress-regulating systems. This affects the formation of psychological deviations and changes in health status, which makes it necessary to take measures for its prevention.

145 girls and 177 boys aged 10–17 years were examined to determine a place of digestive diseases in the structure of somatic pathology in adolescents with nontoxic diffuse goiter. Thyroid ultrasound has been carried out, concentrations of thyroid-stimulating hormone and free fractions of thyroid hormones have been measured. To diagnose concomitant somatic pathology, the authors have performed an extensive complex examination with determination of blood lipids. It is found that most adolescents (87.0 %) had two or more concomitant somatic diseases. Chronic digestive pathology has been detected in 81.5 % of patients, with domination of functional disorders of the gallbladder by a hypotonic type (76.3 %). In adolescents with goiter, we have diagnosed pathological changes in blood lipids due to increased concentrations of beta-lipoproteins (51.9 %), total cholesterol (39.9 %) and low-density lipoprotein cholesterol (23.7 %), which are most characteristic of patients with unfavorable course of thyropathy. Our study has confirmed a close relationship between the blood lipids and thyroid profile.

The study was conducted to determine the neurohormonal mechanisms that underlie the clinical features of puberty onset in children born to parents exposed to low-dose irradiation. Hormonal homeostasis is assessed according to the data of immune-enzyme, radioimmune, and fluorometric methods. Statistical analysis of the data was carried out by means of the application package Excel and Statgrafics-5, SPSS 17.0. It has been established that the earlier puberty onset is caused by accelerated stimulation of pituitary-gonadal system due to activation of central mechanisms of pituitary gonadotrophic function regulation and eary reversal of melatonin blockage of this system. Reasonable basis has been suggested for careful clinical supervision over development of the reproductive system of the children from families with burdened radiation history.