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2. Monomodality versus Combined Therapy in Optic Pathway Gliomas—20-Year Experience from a Singapore Children’s Hospital

Author

Jia Xu Lim, Enrica E.K. Tan, Lee Ping Ng, Wan Tew Seow, Kenneth T.E. Chang, Ru Xin Wong, Wen Shen Looi, David C.Y. Low, and Sharon Y.Y. Low

Subjects
optic pathway glioma, low grade glioma, outcomes, optic chiasmatic gliomas, pediatric glioma, Surgery, RD1-811
Abstract

IntroductionThe treatment of pediatric optic pathway gliomas (OPG) is challenging. At present, most centers provide individualized treatment to maximize progression free survival (PFS) and minimize morbidity. We aim to report our experience in the management of pediatric OPG, and investigate factors associated with an increased duration of remission after treatment.MethodsThis is a single-institution study approved by the hospital ethics board. A retrospective review of consecutive OPGs managed from 2000 to 2020 was performed. Patients were divided into those managed with monomodality treatment (MT) and those who received combined therapy (CT). MT included various forms of surgery, chemotherapy and radiotherapy given alone, while CT involves a combination of surgery and adjuvant chemotherapy and/or radiotherapy.ResultsTwenty-two patients were selected for this study. They had 40 treatment cycles; and a total follow up duration of 194.8 patient-years. Most of them were male (63.6%) and presented with visual deficits (72.7%). The mean age at initial presentation was 65 months and majority (86.4%) had their tumors arising directly from the optic chiasm, with 77.3% with hypothalamic extension. One patient had Neurofibromatosis type I (4.5%). The most common histological diagnosis was pilocytic astrocytoma (90.9%), followed by pilomyxoid astrocytoma (9.1%). The 5- and 10- year PFS were 46.2% and 36.4% respectively, while the 5- and 10-year OS were both 100%. When accounting for treatment type, there were 24 treatment cycles with MT (60.0%) and 16 CT (40.0%). After adjustment, treatments with MT were shown to have a shorter mean duration of remission (MT: 45 ± 49, CT: 84 ± 79 months; p = 0.007). Cox regression curve plotted after adjusting for patient’s age at treatment demonstrated a significantly longer PFS in the CT group (p = 0.037).ConclusionsOur results suggest a significant survival benefit of CT over MT for affected patients due to the prolonged the duration of disease remission, for both primary and subsequent treatments. Nonetheless, we acknowledge that our study reflects the outcomes of treatment strategies that have evolved over time. We emphasize the need for collective efforts from a dedicated multidisciplinary team and international collaborations for better disease understanding.

Published
2022
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3. Study of B0 ??0?0 decays, implications for the CKM angle ?2 and search for other B0 decay modes with a four-pion final state

Author

Vanhoefer, P., Dalseno, J., Kiesling, C., Adachi, I., Aihara, H., Asner, D.M., Aulchenko, V., Aushev, T., Bakich, A.M., Bala, A., Bhardwaj, V., Bhuyan, B., Bonvicini, G., Bozek, A., Bra?ko, M., Browder, T.E., Chang, M.-C., Chang, P., Chekelian, V., Chen, A., Chen, P., Cheon, B.G., Chilikin, K., Chistov, R., Cho, K., Chobanova, V., Choi, Y., Cinabro, D., Dole�al, Z., Dr�sal, Z., Eidelman, S., Farhat, H., Fast, J.E., Ferber, T., Gaur, V., Gabyshev, N., Ganguly, S., Garmash, A., Gillard, R., Goh, Y.M., Golob, B., Hara, T., Hayasaka, K., Hayashii, H., Higuchi, T., Horii, Y., Hoshi, Y., Hou, W.-S., Hyun, H.J., Iijima, T., Ishikawa, A., Itoh, R., Iwasaki, Y., Iwashita, T., Jaegle, I., Julius, T., Kah, D.H., Kato, E., Kawai, H., Kawasaki, T., Kim, D.Y., Kim, H.O., Kim, J.B., Kim, J.H., Kim, M.J., Kim, Y.J., Kinoshita, K., Klucar, J., Ko, B.R., Korpar, S., Kri�an, P., Krokovny, P., Kronenbitter, B., Kuhr, T., Kumita, T., Kuzmin, A., Kwon, Y.-J., Lange, J.S., Lee, S.-H., Li, J., Li Gioi, L., Libby, J., Liu, C., Liu, Y., Liventsev, D., Lukin, P., Miyabayashi, K., Miyata, H., Mizuk, R., Mohanty, G.B., Moll, A., Moser, H.-G., Mussa, R., Nakano, E., Nakao, M., Natkaniec, Z., Nedelkovska, E., Nisar, N.K., Nishida, S., Nitoh, O., Ogawa, S., Pakhlov, P., Pakhlova, G., Park, C.W., Park, H., Park, H.K., Pedlar, T.K., Pestotnik, R., Petri?, M., Piilonen, L.E., Ritter, M., R�hrken, M., Rostomyan, A., Ryu, S., Sahoo, H., Saito, T., Sakai, Y., Sandilya, S., Santelj, L., Sanuki, T., Sato, Y., Savinov, V., Schneider, O., Schnell, G., Schwanda, C., Schwartz, A.J., Semmler, D., Senyo, K., Seon, O., Sevior, M.E., Shapkin, M., Shen, C.P., Shibata, T.-A., Shiu, J.-G., Shwartz, B., Sibidanov, A., Simon, F., Sohn, Y.-S., Sokolov, A., Solovieva, E., Stari?, M., Steder, M., Sumiyoshi, T., Tamponi, U., Tatishvili, G., Teramoto, Y., Trabelsi, K., Tsuboyama, T., Uchida, M., Uehara, S., Unno, Y., Uno, S., Vahsen, S.E., Van Hulse, C., Varner, G., Varvell, K.E., Vinokurova, A., Vorobyev, V., Wagner, M.N., Wang, C.H., Wang, M.-Z., Wang, P., Wang, X.L., Watanabe, Y., Williams, K.M., Won, E., Yamashita, Y., Yashchenko, S., Yook, Y., Zhang, Z.P., Zhilich, V., Zhulanov, V., Zupanc, A.

Abstract

We present a study of the branching fraction of the decay B0??0?0 and the fraction of longitudinally polarized ?0 mesons in this decay. The results are obtained from the final data sample containing 772�106 BB? pairs collected at the (4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. We find 166�59 B0??0?0 events (including systematic uncertainties), corresponding to a branching fraction of B(B0??0?0)=(1.02�0.30(stat) �0.15(syst))�10-6 with a significance of 3.4 standard deviations and a longitudinal polarization fraction fL=0.21-0.22+0.18(stat)�0. 15(syst). We use the longitudinal polarization fraction to determine the Cabibbo-Kobayashi-Maskawa matrix angle ?2=(84.9�13.5)� through an isospin analysis in the B??? system. We furthermore find 125�41 B0?f0?0 events, corresponding to B(B0?f0?0) �B(f0??+?-)=(0.78�0.22(stat)�0.11(syst)) �10-6, with a significance of 3.1 standard deviations. We find no other significant contribution with the same final state, and set upper limits at 90% confidence level on the (product) branching fractions, B(B0??+?- ?+?-)

Published
2014

4. Search for B0 ?p ? ? ?-? at Belle SEARCH for ? Y.-T. LAI et al

Author

Lai, Y.-T., Wang, M.-Z., Adachi, I., Aihara, H., Asner, D.M., Aulchenko, V., Aushev, T., Bakich, A.M., Bala, A., Bhuyan, B., Bobrov, A., Bozek, A., Bra?ko, M., Browder, T.E., Chang, P., Chekelian, V., Chen, A., Chen, P., Cheon, B.G., Cho, I.-S., Cho, K., Chobanova, V., Choi, S.-K., Choi, Y., Cinabro, D., Dalseno, J., Dole�al, Z., Drutskoy, A., Eidelman, S., Farhat, H., Fast, J.E., Ferber, T., Frey, A., Gaur, V., Ganguly, S., Gillard, R., Goh, Y.M., Golob, B., Haba, J., Hayashii, H., Hoshi, Y., Hou, W.-S., Hsiung, Y.B., Iijima, T., Ishikawa, A., Itoh, R., Iwasaki, Y., Iwashita, T., Jaegle, I., Julius, T., Kang, J.H., Kato, E., Kawasaki, T., Kiesling, C., Kim, H.O., Kim, J.H., Kim, M.J., Kim, Y.J., Klucar, J., Ko, B.R., Kody�, P., Korpar, S., Kri�an, P., Krokovny, P., Kuhr, T., Kumita, T., Kwon, Y.-J., Lange, J.S., Lee, S.-H., Li, J., Libby, J., Liu, Y., Lukin, P., Matvienko, D., Miyata, H., Mizuk, R., Moll, A., Mussa, R., Nakano, E., Nakao, M., Nakazawa, H., Nayak, M., Ng, C., Nisar, N.K., Nishida, S., Nitoh, O., Ogawa, S., Onuki, Y., Ozaki, H., Pakhlova, G., Park, C.W., Park, H., Pedlar, T.K., Pestotnik, R., Petri?, M., Piilonen, L.E., Ritter, M., R�hrken, M., Rostomyan, A., Ryu, S., Sahoo, H., Saito, T., Sakai, Y., Sandilya, S., Santel, D., Santelj, L., Sanuki, T., Sato, Y., Schneider, O., Schnell, G., Schwanda, C., Semmler, D., Senyo, K., Shapkin, M., Shen, C.P., Shibata, T.-A., Shiu, J.-G., Shwartz, B., Sibidanov, A., Sohn, Y.-S., Solovieva, E., Stani?, S., Stari?, M., Steder, M., Sumiyoshi, T., Tamponi, U., Tanida, K., Teramoto, Y., Uchida, M., Uehara, S., Uglov, T., Unno, Y., Uno, S., Urquijo, P., Vahsen, S.E., Van Hulse, C., Vanhoefer, P., Varner, G., Vossen, A., Wagner, M.N., Wang, C.H., Wang, P., Watanabe, Y., Williams, K.M., Won, E., Yamaoka, J., Yamashita, Y., Yashchenko, S., Zhang, Z.P., Zhilich, V., Zhulanov, V., Zupanc, A.

Abstract

We search for the charmless B0 decay with final state particles p???-? using the full data sample that contains 772�106BB? pairs collected at the ?(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. This decay is predicted to proceed predominantly via the b?s? radiative penguin process with a high energy photon. No significant signal is found. We set an upper limit of 6.5�10-7 for the branching fraction of B0?p???-? at the 90% confidence level. � 2014 American Physical Society.

Published
2014

6. A 0.13 μm CMOS technology with 193 nm lithography and Cu/low-k for high performance applications

Author

Y.S. Chen, C.S. Hou, J.J. Law, T. Yen, J. Shih, H.C. Hsieh, Y. Ku, L.C. Chao, C.H. Wang, T.C. Ong, J.Y. Cheng, S.Y. Hou, C.H. Yu, S. Shue, S.M. Jeng, M. Chiang, S.H. Chen, C.T. Lin, S.M. Jang, J.H. Chen, K.K. Young, Carlos H. Diaz, T.C. Lo, C.C. Wu, T.E. Chang, J.Y.-C. Sun, Hun-Jan Tao, L.J. Chen, S.Y. Wu, and Mong-Song Liang

Subjects
Engineering, Interconnection, Application-specific integrated circuit, CMOS, business.industry, Low-power electronics, Electrical engineering, Optoelectronics, Dielectric, Static random-access memory, business, Lithography, Electronic circuit
Abstract

A leading-edge 0.13 /spl mu/m CMOS technology using 193 nm lithography and Cu/low-k interconnect is described in this paper. High performance 80 nm core devices use 17 /spl Aring/ nitrided oxide for 1.0-1.2 V operation. These devices deliver unloaded 8.5 ps gate delay @1.2 V. This technology also supports general ASIC applications with 20 /spl Aring/ oxide for 1.2-1.5 V operation and low-standby power applications with 26 /spl Aring/ for 1.5 V operation, respectively. Dual gate oxides of 50 or 65 /spl Aring/ are also supported for 2.5 V or 3.3 V I/O circuits respectively. Cu with low-k dielectric is used for the 8-layer metal interconnect system with tight pitch. The aggressive design rules and border-less contacts/vias support a high density 1P3M 2.43 /spl mu/m/sup 2/ 6T-SRAM cell without local interconnect. A suite of embedded SRAM cells (6T, 8T) with competitive density and performance optimized for different applications are also supported with memory compilers and large block macros.

Published
2002
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7. A 0.15 μm CMOS foundry technology with 0.1 μm devices for high performance applications

Author

M. Chiang, C.C. Wu, K.H. Lee, S. Shue, C.C. Wang, Y.C. Sun, T.E. Chang, L.J. Chen, C.H. Diaz, M. Yu, C. Yang, S.M. Jang, C. Hu, J. Shih, C. Su, C.S. Hou, C.H. Wang, B. Chen, K. Pan, B.K. Liew, M. Chang, W. Chen, P. Lu, H. Su, Hun-Jan Tao, H.C. Hsieh, and S. Chang

Subjects
Engineering, Application-specific integrated circuit, CMOS, business.industry, Low-power electronics, Sram cell, Technology scaling, Electrical engineering, Low-k dielectric, Metal interconnect, Foundry, business
Abstract

This paper describes a leading-edge 0.15 /spl mu/m CMOS logic foundry technology family. Advanced core devices using 20 /spl Aring/ oxides for 1.2-1.5 V operation (L/sub G min/=0.1 /spl mu/m) support high-performance CPU and graphics applications. The technology supports also low-standby power applications with 26 /spl Aring/ oxide for 1.5 V operation. Periphery circuitry for 2.5 or 3.3 V compatibility use dual 50 or 65 /spl Aring/ gate oxides respectively. AlCu with low-k (FSG) is used for the seven-level metal interconnect system with extremely tight pitch (0.39 /spl mu/m for M1 and 0.48 /spl mu/m for intermediate levels). The aggressive design rules and border-less contacts/vias render an embedded (synchronous cache) 6T SRAM cell of 3.42 /spl mu/m/sup 2/ demonstrated in a 2Mb vehicle with very high yield. The overall process reliability is also shown to meet standard industry requirements.

Published
2002
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9. Symptomatic radionecrosis of cerebral arteriovenous malformation post-stereotactic radiosurgery: Report of 2 cases

Author

Sharon Y.Y. Low, PhD, FRCS, Jabed Iqbal, MD, AM.BD. Pathology, Kenneth T.E. Chang, FRCPath, and Roy K.M. Koh, FRCS

Subjects
Surgery, RD1-811, Neurology. Diseases of the nervous system, RC346-429
Abstract

Stereotactic radiosurgery (SRS) is an effective and non-invasive modality for the treatment of cerebral arteriovenous malformation (cAVM). Delayed radionecrosis may occur in a small percentage of them, with the majority of their symptoms being transient. We present 2 patients who developed persistently symptomatic radionecrosis lesions post-SRS of their cAVMs. Currently, causative factors underlying this phenomenon remain unelucidated. In addition, there are no biological markers to identify patients at risk of developing progressive lesions. Given the infrequency of such cases, the disease is discussed in corroboration with current literature and management strategies. Keywords: Cerebral arteriovenous malformation, Radionecrosis, Stereotactic radiosurgery

Published
2019
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