7 results on '"T. Taeumer"'
Search Results
2. Stellenwert von Gerinnungsstörungen bei Patienten mit Epistaxis
- Author
-
A. de Greiff, I. Scharrer, T. Mewes, K. Papaspyrou, Wolf J. Mann, and T. Taeumer
- Subjects
Gynecology ,medicine.medical_specialty ,Otorhinolaryngology ,business.industry ,medicine ,Von Willebrand disease ,Coagulopathy ,Head and neck surgery ,Factor XIII deficiency ,medicine.disease ,business ,Blood coagulation test - Abstract
Hintergrund Dem Auftreten von Nasenbluten kann eine Vielzahl von lokalen sowie systemischen Ursachen zugrunde liegen. Epistaxis ist ein Leitsymptom der haufigsten angeborenen Gerinnungsstorung, des von-Willebrand-Syndroms (VWS), welches mit einer Pravalenz von etwa 1% in der Normalbevolkerung angegeben wird. Zur Diagnosestellung des VWS oder auch eines Mangels an Faktor XIII (FXIII) sowie einer Thrombozytendysfunktion reichen die Parameter der ublichen globalen Gerinnungstests (Quick/INR, aPTT, Thrombozytenzahl) jedoch nicht aus.
- Published
- 2011
3. A single nasal allergen challenge increases induced sputum inflammatory markers in non-asthmatic subjects with seasonal allergic rhinitis: correlation with plasma interleukin-5
- Author
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Roland Buhl, C. Meier, Oliver Kornmann, T. Taeumer, Jutta Beier, and Kai Michael Beeh
- Subjects
Allergy ,biology ,business.industry ,Immunology ,Provocation test ,medicine.disease ,medicine.disease_cause ,Immunoglobulin E ,respiratory tract diseases ,Allergic inflammation ,Allergen ,medicine ,biology.protein ,Immunology and Allergy ,Sputum ,medicine.symptom ,business ,Interleukin 5 ,Asthma - Abstract
BACKGROUND Seasonal allergic rhinitis (SAR) is a risk factor for asthma in affected individuals. Nasal allergic inflammation enhances bone-marrow eosinophil production, mainly via IL-5, and rhinitis patients have increased airway inflammation during the pollen season. OBJECTIVE To assess the impact of nasal allergy on sputum inflammatory markers. METHODS In an open-labelled, randomized, placebo-controlled cross-over study with 16 non-asthmatic SAR patients (median age 25 years, 56% males), the effect of a single nasal allergen challenge performed out of season on induced sputum inflammatory parameters was evaluated. SAR patients were identified by history, skin-prick test and specific IgE. All patients had normal lung function/bronchial hyper-responsiveness out of season and a negative asthma/wheezing history. Sputum cells and supernatant levels of ECP, sICAM, IL-5 and IL-10, and plasma levels of IL-5 and ECP, were measured before and 24 h after nasal allergen challenge. After a washout period of at least 4 weeks, the procedure was repeated with placebo challenge (diluent). RESULTS Nasal allergen challenge led to an increase in sputum ECP (pre = 60 +/- 12, post = 212 +/- 63 micro g/L, P = 0.02 vs. placebo), and sICAM (4.8 +/- 2.7 to 6.5 +/- 2.9 ng/mL, P = 0.02 vs. placebo), whereas IL-10 decreased after provocation (44 +/- 11 to 29 +/- 6 pg/mL, P = 0.06 vs. placebo). Sputum IL-5 was undetectable in all patients. The absolute number of blood and sputum eosinophils did not change significantly after allergen or placebo challenge (P > 0.07, both comparisons). Plasma levels of IL-5 increased after allergen challenge (8.7 +/- 2.9 to 14.5 +/- 3.9 pg/mL, P = 0.001), and the increase in plasma IL-5 was positively correlated with the rise in sputum ECP in a subgroup of 'responders' (n = 12, r = 0.71, P = 0.01). CONCLUSIONS A single nasal allergen challenge in SAR patients increased markers of allergic inflammation in the lower respiratory tract, possibly via pronounced activation of inflammatory cells through circulating immediate-type reaction cytokines like IL-5. These findings may provide additional explanatory data for the high susceptibility of SAR patients to incident asthma.
- Published
- 2003
4. [The significance of bleeding disorders in patients with epistaxis]
- Author
-
T, Taeumer, A, de Greiff, I, Scharrer, K, Papaspyrou, T, Mewes, and W, Mann
- Subjects
Adult ,Male ,Comorbidity ,Middle Aged ,Risk Assessment ,von Willebrand Diseases ,Epistaxis ,Risk Factors ,Germany ,Prevalence ,Humans ,Female ,Blood Coagulation Tests ,Aged - Abstract
Epistaxis can have a variety of different local or systemic causes. It is the cardinal symptom of von Willebrand disease (VWD), the most frequent congenital bleeding disorder with a prevalence of approximately 1%. The usual routine coagulation screening tests (PT, APTT, platelet count) are not sufficient to diagnose VWD, factor XIII (FXIII)-deficiency or platelet dysfunction.A prospective study was conducted implementing enhanced coagulation screening for bleeding disorders in a total of 100 inpatients admitted for epistaxis.A bleeding disorder was found in 13%. In eight patients VWD was diagnosed, in six patients FXIII-deficiency was found, and in one patient both.The prevalence of bleeding disorders in patients with epistaxis is higher than in the general population. Epistaxis can be the primary symptom of chronic inflammatory disease or malignant disease. A thorough anamnesis is necessary and in cases of doubt additional testing for underlying disorders is recommended.
- Published
- 2011
5. A single nasal allergen challenge increases induced sputum inflammatory markers in non-asthmatic subjects with seasonal allergic rhinitis: correlation with plasma interleukin-5
- Author
-
K M, Beeh, J, Beier, O, Kornmann, C, Meier, T, Taeumer, and R, Buhl
- Subjects
Adult ,Male ,Cross-Over Studies ,Sputum ,Rhinitis, Allergic, Seasonal ,Allergens ,Bronchoconstrictor Agents ,Humans ,Regression Analysis ,Female ,Interleukin-5 ,Administration, Intranasal ,Biomarkers ,Methacholine Chloride - Abstract
Seasonal allergic rhinitis (SAR) is a risk factor for asthma in affected individuals. Nasal allergic inflammation enhances bone-marrow eosinophil production, mainly via IL-5, and rhinitis patients have increased airway inflammation during the pollen season.To assess the impact of nasal allergy on sputum inflammatory markers.In an open-labelled, randomized, placebo-controlled cross-over study with 16 non-asthmatic SAR patients (median age 25 years, 56% males), the effect of a single nasal allergen challenge performed out of season on induced sputum inflammatory parameters was evaluated. SAR patients were identified by history, skin-prick test and specific IgE. All patients had normal lung function/bronchial hyper-responsiveness out of season and a negative asthma/wheezing history. Sputum cells and supernatant levels of ECP, sICAM, IL-5 and IL-10, and plasma levels of IL-5 and ECP, were measured before and 24 h after nasal allergen challenge. After a washout period of at least 4 weeks, the procedure was repeated with placebo challenge (diluent).Nasal allergen challenge led to an increase in sputum ECP (pre = 60 +/- 12, post = 212 +/- 63 micro g/L, P = 0.02 vs. placebo), and sICAM (4.8 +/- 2.7 to 6.5 +/- 2.9 ng/mL, P = 0.02 vs. placebo), whereas IL-10 decreased after provocation (44 +/- 11 to 29 +/- 6 pg/mL, P = 0.06 vs. placebo). Sputum IL-5 was undetectable in all patients. The absolute number of blood and sputum eosinophils did not change significantly after allergen or placebo challenge (P0.07, both comparisons). Plasma levels of IL-5 increased after allergen challenge (8.7 +/- 2.9 to 14.5 +/- 3.9 pg/mL, P = 0.001), and the increase in plasma IL-5 was positively correlated with the rise in sputum ECP in a subgroup of 'responders' (n = 12, r = 0.71, P = 0.01).A single nasal allergen challenge in SAR patients increased markers of allergic inflammation in the lower respiratory tract, possibly via pronounced activation of inflammatory cells through circulating immediate-type reaction cytokines like IL-5. These findings may provide additional explanatory data for the high susceptibility of SAR patients to incident asthma.
- Published
- 2003
6. [The significance of bleeding disorders in patients with epistaxis].
- Author
-
Taeumer T, de Greiff A, Scharrer I, Papaspyrou K, Mewes T, and Mann W
- Subjects
- Adult, Aged, Comorbidity, Epistaxis blood, Female, Germany epidemiology, Humans, Male, Middle Aged, Prevalence, Risk Assessment, Risk Factors, von Willebrand Diseases blood, Blood Coagulation Tests statistics & numerical data, Epistaxis diagnosis, Epistaxis epidemiology, von Willebrand Diseases diagnosis, von Willebrand Diseases epidemiology
- Abstract
Background: Epistaxis can have a variety of different local or systemic causes. It is the cardinal symptom of von Willebrand disease (VWD), the most frequent congenital bleeding disorder with a prevalence of approximately 1%. The usual routine coagulation screening tests (PT, APTT, platelet count) are not sufficient to diagnose VWD, factor XIII (FXIII)-deficiency or platelet dysfunction., Method: A prospective study was conducted implementing enhanced coagulation screening for bleeding disorders in a total of 100 inpatients admitted for epistaxis., Results: A bleeding disorder was found in 13%. In eight patients VWD was diagnosed, in six patients FXIII-deficiency was found, and in one patient both., Conclusion: The prevalence of bleeding disorders in patients with epistaxis is higher than in the general population. Epistaxis can be the primary symptom of chronic inflammatory disease or malignant disease. A thorough anamnesis is necessary and in cases of doubt additional testing for underlying disorders is recommended.
- Published
- 2011
- Full Text
- View/download PDF
7. A single nasal allergen challenge increases induced sputum inflammatory markers in non-asthmatic subjects with seasonal allergic rhinitis: correlation with plasma interleukin-5.
- Author
-
Beeh KM, Beier J, Kornmann O, Meier C, Taeumer T, and Buhl R
- Subjects
- Administration, Intranasal, Adult, Biomarkers analysis, Bronchoconstrictor Agents, Cross-Over Studies, Female, Humans, Male, Methacholine Chloride, Regression Analysis, Allergens, Interleukin-5 blood, Rhinitis, Allergic, Seasonal immunology, Sputum immunology
- Abstract
Background: Seasonal allergic rhinitis (SAR) is a risk factor for asthma in affected individuals. Nasal allergic inflammation enhances bone-marrow eosinophil production, mainly via IL-5, and rhinitis patients have increased airway inflammation during the pollen season., Objective: To assess the impact of nasal allergy on sputum inflammatory markers., Methods: In an open-labelled, randomized, placebo-controlled cross-over study with 16 non-asthmatic SAR patients (median age 25 years, 56% males), the effect of a single nasal allergen challenge performed out of season on induced sputum inflammatory parameters was evaluated. SAR patients were identified by history, skin-prick test and specific IgE. All patients had normal lung function/bronchial hyper-responsiveness out of season and a negative asthma/wheezing history. Sputum cells and supernatant levels of ECP, sICAM, IL-5 and IL-10, and plasma levels of IL-5 and ECP, were measured before and 24 h after nasal allergen challenge. After a washout period of at least 4 weeks, the procedure was repeated with placebo challenge (diluent)., Results: Nasal allergen challenge led to an increase in sputum ECP (pre = 60 +/- 12, post = 212 +/- 63 micro g/L, P = 0.02 vs. placebo), and sICAM (4.8 +/- 2.7 to 6.5 +/- 2.9 ng/mL, P = 0.02 vs. placebo), whereas IL-10 decreased after provocation (44 +/- 11 to 29 +/- 6 pg/mL, P = 0.06 vs. placebo). Sputum IL-5 was undetectable in all patients. The absolute number of blood and sputum eosinophils did not change significantly after allergen or placebo challenge (P > 0.07, both comparisons). Plasma levels of IL-5 increased after allergen challenge (8.7 +/- 2.9 to 14.5 +/- 3.9 pg/mL, P = 0.001), and the increase in plasma IL-5 was positively correlated with the rise in sputum ECP in a subgroup of 'responders' (n = 12, r = 0.71, P = 0.01)., Conclusions: A single nasal allergen challenge in SAR patients increased markers of allergic inflammation in the lower respiratory tract, possibly via pronounced activation of inflammatory cells through circulating immediate-type reaction cytokines like IL-5. These findings may provide additional explanatory data for the high susceptibility of SAR patients to incident asthma.
- Published
- 2003
- Full Text
- View/download PDF
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