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2. Poster session 1
- Author
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J. Schlueter, T. Brand, D. J. Henderson, V. Boczonadi, P. Humbert, B. Chaudhry, D. Sedmera, J. Svatunkova, R. Kockova, B. Sankova, C. Lopez Sanchez, D. Franco, A. Aranega, V. Garcia-Martinez, E. Demina, V. Miroshikova, A. Denisenko, A. Schwarzman, F. Sanchez-Cabo, C. Torroja, A. Benguria, R. Buchan, P. Srivastava, F. Martinez, P. Barton, S. Cook, A. Dopazo, E. Lara-Pezzi, H. Rai, S. Kumar, A. K. Sharma, S. Mastana, A. Kapoor, C. M. Pandey, S. Agrawal, N. Sinha, J. Lipkova, M. Goldbergova, J. Parenica, J. Bienertova Vasku, A. Vasku, P. Kala, J. Spinar, L. Perez-Cabornero, D. Cantalapiedra, A. Forteza, R. Saez-Villaverde, J. Zumalde, V. Fernandez-Pedrosa, S. Zuniga-Trejos, M. Gil-Borja, M. Lazaro, S. Santillan, M. Costa, N. Cortez-Dias, P. Carrilho-Ferreira, D. Silva, C. Jorge, R. Placido, C. Calisto, M. Fiuza, A. Nunes Diogo, F. J. Enguita, H. H. W. Sillje, B. Lu, H. Yu, M. Zwartbol, W. P. Ruifrok, W. H. Van Gilst, R. A. De Boer, D. Zaliaduonyte-Peksiene, S. Simonyte, V. Lesauskaite, J. Vaskelyte, V. Mizariene, R. Zaliunas, W. Tigchelaar, E. Barlaka, A. Lazou, C. Del Giudice, E. Cipolletta, A. Anastasio, G. Santulli, M. Rusciano, A. S. Maione, P. Campiglia, M. Illario, B. Trimarco, G. Iaccarino, G. A. Frentzou, M. J. Drinkhill, N. A. Turner, S. G. Ball, J. F. X. Ainscough, L. Bertrand, F. Mailleux, J. Hammond, A. Ginion, L. Hue, J. L. Balligand, S. Horman, J. L. Vanoverschelde, C. Beauloye, B. Demeulder, S. L. Puhl, A. Mueller, Y. Devaux, D. R. Wagner, K. Roemer, M. Boehm, C. Maack, D. Miranda-Silva, I. Falcao-Pires, N. Goncalves, D. Moreira-Goncalves, A. F. Leite-Moreira, F. Mraiche, L. Fliegel, J. Xue, G. G. Haddad, L. C. Hsiao, C. Carr, Z. F. Cui, K. Clarke, M. A. D'amico, P. Izzicupo, A. Di Fonso, A. Bascelli, S. Gallina, A. Di Baldassarre, C. Silvestre, P. Fernandez, O. M. Pello, C. Indolfi, F. Civeira, R. Hutter, B. Ibanez, J. Chaves, J. Martinez-Gonzalez, V. Andres Garcia, A. Zabirnik, N. Smolina, A. Malashicheva, E. Omelchenko, T. Sejersen, A. Kostareva, C. Noack, M. P. Zafiriou, A. Renger, R. Dietz, H. J. Schaeffer, M. B. Bergmann, C. Zelarayan, S. Van Linthout, K. Miteva, M. P. Becher, M. Haag, J. Ringe, H.-P. schultheiss, M. Sittinger, C. Tschoepe, T. Kakuchaya, L. Bockeria, E. Golukhova, M. Eremeeva, N. Chigogidze, I. Aslanidi, I. Shurupova, A. Svobodov, A. A. Ramkisoensing, D. A. Pijnappels, J. Swildens, M. J. Goumans, M. J. Schalij, A. A. F. De Vries, D. E. Atsma, A. Gomes, G. M. Costa, C. A. Cordeiro, A. Matsuada, L. B. Rosario, A. P. Freire, M. Bousquenaud, M. Rolland-Turner, F. Maskali, L. Zhang, P. Y. Marie, F. Azuaje, A. J. Smith, G. M. Ellison, C. D. Waring, S. Purushothaman, D. Torella, B. Nadal-Ginard, M. H. Van Marion, D. W. J. Van Der Schaft, M.-J. Goumans, F. P. T. Baaijens, C. V. C. Bouten, N. Kraenkel, K. Kuschnerus, M. Mueller, T. Speer, S. Briand, M. Bader, P. Madeddu, T. F. Luescher, U. Landmesser, A. Papalamprou, C. Vicinanza, D. F. Goldspink, M. Noseda, S. J. Mcsweeney, T. Leja, E. Belian, I. Macaulay, F. Al-Beidh, S. Koenemann, M. S. Abreu Pavia, S. E. Jacobsen, M. D. Schneider, G. Foldes, Z. Bagyura, Z. Lendvai, D. Mathe, T. Nemeth, J. Skopal, I. Foldes, B. Merkely, S. E. Harding, A. J. Candasamy, R. S. Haworth, A. Boguslavsky, F. Cuello, M. J. Shattock, M. Mayr, M. Gautel, M. Avkiran, P. Leszek, B. Sochanowicz, M. Szperl, P. Kolsut, K. Brzoska, W. Piotrowski, T. Rywik, B. Danko, J. Rozanski, M. Kruszewski, N. Bouteldja, R. J. Woodman, C. L. Hewitson, E. Domingo, J. A. Barbara, A. A. Mangoni, R. Carnicer Hijazo, A. B. Hale, X. Liu, S. Suffredini, J. K. Bendall, G. B. S. Lim, N. J. Alp, K. M. Channon, B. Casadei, L. R. Moltzau, J. M. Aronsen, S. Meier, I. Sjaastad, T. Skomedal, J.-B. Osnes, F. O. Levy, E. Qvigstad, P. T. Wright, L. M. K. Pannell, A. R. Lyon, J. Gorelik, A. Guellich, S. F. Vatner, R. Fischmeister, B. Manoury, E. Dubois, J. Hamelet, A. Vanderper, P. Herijgers, D. Langin, F. Gartner, J. Gummert, H. Milting, G. Euler, M. Priess, J. Heger, T. Noll, R. Schulz, T. Doi, T. Akagami, T. Naka, T. Masuyama, M. Ohyanagi, M. Massaro, E. Scoditti, M. Pellegrino, M. A. Carluccio, C. Martines, C. Storelli, R. De Caterina, M. Falck-Hansen, M. E. Goddard, J. E. Cole, N. Astola, A. J. Cross, R. Krams, C. Monaco, M. F. Corsten, W. Verhesen, A. P. Papageorgiou, P. Carai, M. Lindow, S. Obad, G. Summer, L. De Rijck, S. Coort, M. Hazebroek, R. Van Leeuwen, M. Gijbels, M. P. J. De Winther, F. R. M. Stassen, S. Kauppinen, B. Schroen, S. Heymans, Z. Husti, V. Juhasz, L. Virag, A. Kristof, I. Koncz, T. Szel, I. Baczko, N. Jost, J. G. Y. Papp, A. Varro, A. Ghigo, A. Perino, F. Damilano, J. Leroy, V. O. Nikolaev, W. Richter, M. Conti, G. Vandecasteele, E. Hirsch, R. Ang, S. Sebastian, A. Ludwig, L. Birnbaumer, A. Tinker, E. A. Ertel, R. Sube, A. Opel, C. L-H Huang, A. Grace, N. Tribulova, J. Radosinska, B. Bacova, T. Benova, V. Knezl, J. Slezak, T. A. Matsuyama, T. Tanaka, T. Adachi, Y. Jiang, H. Ishibashi-Ueda, T. Takamatsu, J. Kornej, C. Reihardt, J. Kosiuk, A. Arya, G. Hindricks, V. Adams, D. Husser, A. Bollmann, S. Severi, M. Fantini, E. Ravagli, L. A. Charawi, D. Difrancesco, C. Poulet, L. Lu, U. R. Ravens, M. Hoch, T. Koenig, A. Gardiwal, B. Stapel, S. Erschow, A. Froese, B. Weinhold, R. Gerardy-Schahn, G. Klein, D. Hilfiker-Kleiner, K. Chinda, S. Palee, S. Surinkaew, M. Phornphutkul, S. Chattipakorn, N. Chattipakorn, B. Tuana, Z. Kohajda, A. A. Kristof, C. Corici, F. Fulop, N. L. Jost, V. Szuts, D. Menesi, G. L. Puskas, A. Zvara, N. Houshmand, J. G. Papp, N. Al-Shanti, M. Hancock, A. Venturini, C. Stewart, R. Ascione, G. Angelini, M.-S. Suleiman, A. Gonzalez-Tendero, I. Torre, F. Crispi, E. Gratacos, T. Tzanavari, E. Varela, A. Economides, S. Theocharis, C. Pantos, D. V. Cokkinos, A. Karalis, P. Hecker, V. Lionetti, W. C. Stanley, C. Ferrara, N. Piroddi, B. Scellini, C. Ferrantini, V. Sequiera, C. Remedios, L. Carrier, C. Tesi, J. Van Der Velden, C. Poggesi, V. Kooij, G. J. M. Stienen, D. Dooijes, s. Marston, C. Redwood, C. Dos Remedios, I. Diakonov, S. Tokar, M. Sikkel, S. Schlossarek, M. Sauer, A. Papageorgiou, S. Velthuis, E. Lutgens, M. Swinnen, N. Van Rooijen, J. Kzhyshkowska, P. Carmeliet, P. Garcia-Canadilla, F. Garcia-Garcia, I. Iruretagoiena, J. Dopazo, I. Amat-Roldan, M. H. Zhang, Y. H. Zhang, C. E. Sears, B. Wojtas, A. Llach, L. Hove-Madsen, V. Spinelli, L. Sartiani, M. Bucciantini, R. Coppini, E. Russo, A. Mugelli, E. Cerbai, M. Stefani, M. Ibrahim, P. Kukadia, M. Navaratnarajah, U. Siedlecka, C. Van Doorn, M. Yacoub, C. Terracciano, W. Song, N. Curtin, R. Woledge, S. Marston, M. Balteau, N. Tajeddine, G. Behets-Wydemans, C. Dessy, P. Gailly, W. J. Van Der Laarse, S. J. P. Bogaards, D. Van Groen, Y. Y. Wong, I. Schalij, A. Vonk Noordegraaf, F. M. Faz, B. Littlejohns, P. Pasdois, A. P. Halestrap, G. D. Angelini, S. Lemoine, V. Jaspard-Vinassa, F. Vigneron, P. Dos Santos, M. Popescu, A. Vlad, G. Isvoranu, L. Suciu, B. Marinescu, D. Dimulescu, L. Zagrean, P. W. M. Kleikers, K. Wingler, K. Radermacher, A. Sydykov, H. A. Ghofrani, N. Weissmann, H. H. W. Schmidt, A. Poddubnaya, K. E. M. Khurs, S. O. G. Smolenskaya, G. Szucs, Z. Murlasits, S. Torok, G. F. Kocsis, T. Csont, C. Csonka, P. Ferdinandy, R. Dongworth, D. M. Yellon, D. J. Hausenloy, Y. Y. Chen, W. S. Lian, C. F. Cheng, K. H. Khoo, T. C. Meng, G. Youcef, E. Belaidi, L. Fazal, M. P. Vinvent, D. De Paulis, G. Zadigue, C. Richer-Giudicelli, F. Alhenc-Gelas, M. Ovize, A. Pizard, R. Cal, J. Castellano, J. Farre, G. Vilahur, L. Badimon, V. Llorente-Cortes, H. Naz, M. Gharanei, C. Mee, H. Maddock, A. Hussain, O. Pisarenko, V. Shulzhenko, L. Serebryakova, I. Studneva, Y. Pelogeykina, D. Khatri, O. Tskitishvili, E. Barnucz, G. Veres, P. Hegedus, T. Radovits, S. Korkmaz, S. Klein, R. Zoller, M. Karck, G. Szabo, S. Morel, M. A. Frias, C. Rosker, R. W. James, S. Rohr, B. R. Kwak, V. Braunersreuther, B. Foglia, F. Mach, E. Shantsila, S. Montoro-Garcia, L. D. Tapp, S. Apostolakis, B. J. Wrigley, G. Y. H. Lip, E. Sokolowska, K. Przyborowski, K. Kramkowski, W. Buczko, A. Mogielnicki, U. Simonsen, E. R. Hedegaard, B. D. Nielsen, A. Kun, A. Hughes, C. Kroigaard, S. Mogensen, O. Frobert, K. Ait Aissa, J. P. Max, D. Wahl, T. Lecompte, P. Lacolley, V. Regnault, A. Novakovic, M. Pavlovic, A. Vranic, P. Milojevic, I. Stojanovic, M. Jovic, D. Nenezic, N. Ugresic, Q. Yang, G. W. He, L. Calvier, P. Reboul, B. Martin-Fernandez, V. Lahera, F. Zannad, V. Cachofeiro, P. Rossignol, N. Lopez-Andres, V. K. Pulakazhi Venu, R. Baetta, A. Bonomo, A. F. Muro, A. Corsini, A. L. Catapano, G. D. Norata, L. E. Viiri, L. E. Full, T. J. Navin, A. Didangelos, I. Seppala, T. Lehtimaki, A. H. Davies, R. Wait, D. Sedding, P. Stieger, C. Thoelen, S. Fischer, J. M. Daniel, R. Widmer-Teske, K. T. Preissner, N. Alenina, L. A. Rabelo, M. Todiras, V. N. Souza, J. M. Penninger, R. A. Santos, I. A. Leonova, S. A. Boldueva, V. S. Feoktistova, O. V. Sirotkina, M. G. Kolesnichenko, Z. Springo, P. Toth, P. Cseplo, G. Szijjarto, A. Koller, S. Puthenkalam, M. K. Frey, I. M. Lang, R. Madonna, H. Shelat, Y. J. Geng, T. Ziegler, V. Pfetsch, J. Horstkotte, C. Schwab, I. Rohwedde, R. Hinkel, Q. Di, S. Dietzel, U. Deutsch, C. Kupatt, I. Ernens, B. Lenoir, O. Fortunato, A. Caporali, E. Sangalli, D. Cordella, M. Marchetti, G. Spinetti, C. Emanueli, G. Arderiu, E. Pena, M. J. Forteza, V. Bodi, S. Novella, C. Alguero, I. Trapero, I. Benet, C. Hermenegildo, J. Sanchis, F. J. Chorro, A. Nemeth, S. Szabados, A. Cziraki, E. Sulyok, I. G. Horvath, M. Rauh, W. Rascher, I. Sikharulidze, I. B. Bakhlishvili, J. T. T. Laitinen, J. P. Hytonen, O. Leppanen, J. Taavitsainen, A. Partanen, P. Korpisalo, S. Yla-Herttuala, J. Lonn, J. Hallstrom, T. Bengtsson, M. C. Guisasola, E. Dulin, S. Stojkovic, C. Kaun, G. Maurer, K. Huber, J. Wojta, S. Demyanets, T. B. Opstad, A. Pettersen, S. Aakra, H. Arnesen, I. Seljeflot, M. Borrell-Pages, C. Romero, A. Toso, M. Leoncini, L. Tanini, T. Pizzetti, F. Tropeano, M. Maioli, P. Casprini, F. Bellandi, R. F. Antunes, J. C. Kaski, I. E. Dumitriu, E. Wu, A. A. L. Tareen, M. Udovychenko, I. Rudyk, K. Riches, L. Franklin, A. Maqbool, J. Bond, M. L. Koschinsky, D. J. O'regan, K. E. Porter, I. R. Parepa, A. I. Suceveanu, A. Suceveanu, L. Mazilu, L. Cojocaru, A. Rusali, L. A. Tuta, E. Craiu, D. Lindner, C. Zietsch, H.-P. Schultheiss, C. Tschope, D. Westermann, M. Miana, E. Martinez, R. Jurado, C. Delgado, N. Gomez-Hurtado, A. Briones, J. Young, T. J. Geng, A. Brodehl, T. Schmidt, O. Smolenskaya, C. Stegemann, D. Byzov, I. Mikhaylova, N. Chizh, E. Pushkova, O. Synchykova, B. Sandomirsky, O. Freylikhman, O. Rotar, N. Chromova, E. Moguchaya, V. Ivanenko, E. Kolesova, A. Erina, M. Boyarinova, A. Konradi, S. D. Preston, D. Baskaran, A. M. Plonczak, K. Norita, S. V. De Noronha, M. N. Sheppard, A. Haghikia, S. F. Hill, M. Hoepfner, B. Nitzsche, M. Schrader, F. Zengerling, B. Hoffmann, A. Pries, S. Gao, J. T. Laitinen, S. Laidinen, H. Markkanen, H. Karvinen, V. Marjomaki, I. Vajanto, T. T. Rissanen, K. Alitalo, P. Mello Ferrao, M. C. Waghabi, L. R. Garzoni, J. Ritterhoff, C. Weidenhammer, M. Voelkers, W. H. Zimmermann, J. Rabinowitz, P. Most, S. C. Gordts, I. Muthuramu, F. Jacobs, E. Van Craeyveld, E. Nefyodova, B. De Geest, D. R. Tribuddharat, D. R. Sathitkarnmanee, M. R. Buddhisa, M. S. Suwannasaen, D. R. Silarat, D. R. Ngamsangsirisup, D. R. Hawrylowicz, D. R. Lertmemongkolchai, S. Rain, M. L. Handoko, N. Westerhof, A. Vonk-Noordegraaf, F. S. De Man, A. S. Iakovleva, O. A. Mirolyubova, A. Berezin, T. A. Samura, Suwannasaen, Tippayawat, Ngamsangsirisup, D. R. Sutra, Hawrylowicz, Lertmemongkolchai, L. M. Lima, M. G. Carvalho, D. R. G. Junqueira, M. O. Sousa, A. Zampetaki, P. Willeit, L. Tilling, I. Drozdov, M. Prokopi, A. Shah, C. Boulanger, P. Chowienczyk, S. Kiechl, S. H. V. Oliveira, V. Kirillova, E. Prosviryakov, C. T. M. Van Der Pouw Kraan, F. J. P. Bernink, J. M. Baggen, L. Timmers, A. M. Beek, M. Diamant, A. C. Van Rossum, N. Van Royen, A. J. G. Horrevoets, J. E. A. Appelman, A. Zyatenkov, L. S. Kokov, Y. U. D. Volynskiy, M. Krestjyaninov, V. I. Ruzov, A. V. Villar, E. Martinez-Laorden, A. Almela, M. A. Hurle, M. L. Laorden, N. Apaijai, M. K. Mcmullen, J. M. Whitehouse, G. Shine, and A. Towell
- Subjects
Gerontology ,Physiology ,business.industry ,Physiology (medical) ,Cancer research ,Medicine ,SCRIB gene ,Cardiology and Cardiovascular Medicine ,business - Published
- 2012
3. Poster session 2
- Author
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J. M. Perez-Pomares, A. Ruiz-Villalba, A. Ziogas, J. C. Segovia, M. Ehrbar, R. Munoz-Chapuli, A. De La Rosa, J. N. Dominguez, L. Hove-Madsen, B. Sankova, D. Sedmera, D. Franco, A. Aranega Jimenez, G. Babaeva, N. Chizh, S. Galchenko, B. Sandomirsky, M. Schwarzl, S. Seiler, P. Steendijk, S. Huber, H. Maechler, M. Truschnig-Wilders, B. Pieske, H. Post, S. Simrick, R. Kreutzer, C. Rao, C. M. Terracciano, P. Kirchhof, L. Fabritz, T. Brand, M. Theveniau-Ruissy, P. Parisot, A. Francou, E. Saint-Michel, K. Mesbah, R. G. Kelly, H.-T. Wu, S.-S. Sie, C.-Y. Chen, T.-C. Kuan, C. S. Lin, Z. Ismailoglu, M. Guven, A. Yakici, Y. Ata, S. Ozcan, E. Yildirim, Z. Ongen, V. Miroshnikova, E. Demina, T. Rodygina, P. Kurjanov, A. Denisenko, A. Schwarzman, A. Rubanenko, Y. Shchukin, A. Germanov, M. Goldbergova, J. Parenica, J. Lipkova, N. Pavek, P. Kala, M. Poloczek, A. Vasku, I. Parenicova, J. Spinar, C. Gambacciani, E. Chiavacci, M. Evangelista, N. Vesentini, C. Kusmic, L. Pitto, A. Chernova, S. U. Y. Nikulina, D. A. Arvanitis, I. Mourouzis, C. Pantos, E. G. Kranias, D. V. Cokkinos, D. Sanoudou, T. E. Vladimirskaya, I. A. Shved, S. G. Kryvorot, I. M. Schirmer, A. Appukuttan, L. Pott, K. Jaquet, Y. Ladilov, C. R. Archer, M. D. Bootman, H. L. Roderick, A. Fusco, D. Sorriento, G. Santulli, B. Trimarco, G. Iaccarino, M. Hagenmueller, J. Riffel, E. Bernhold, H. A. Katus, S. E. Hardt, A. Maqsood, M. Zi, S. Prehar, L. Neyses, S. Ray, D. Oceandy, N. Khatami, P. Wadowski, V. Wagh, J. Hescheler, A. Sachinidis, W. Mohl, B. Chaudhry, D. Burns, D. J. Henderson, N. A. M. Bax, M. H. Van Marion, B. Shah, M. J. Goumans, C. V. C. Bouten, D. W. J. Van Der Schaft, A. A. M. Van Oorschot, S. Maas, J. Braun, J. Van Tuyn, A. A. F. De Vries, A. C. Gittenberger-De Groot, S. Bageghni, M. J. Drinkhill, T. F. C. Batten, J. F. X. Ainscough, B. Onate, G. Vilahur, R. Ferrer-Lorente, J. Ybarra, A. Diez-Caballero, C. Ballesta-Lopez, F. Moscatiello, J. Herrero, L. Badimon, E. Martin-Rendon, D. M. Clifford, S. A. Fisher, S. J. Brusnkill, C. Doree, A. Mathur, M. Clarke, S. M. Watt, R. Hernandez-Vera, D. Kavanagh, A. I. Yemm, J. Frampton, N. Kalia, Y. Terajima, T. Shimizu, S. Tsuruyama, H. Ishii, H. Sekine, N. Hagiwara, T. Okano, K. R. Vrijsen, S. A. J. Chamuleau, J. P. G. Sluijter, P. F. M. Doevendans, R. Madonna, S. Delli Pizzi, L. Di Donato, A. Mariotti, L. Di Carlo, E. D'ugo, M. A. Teberino, A. Merla, A. T, R. De Caterina, L. Kolker, N. N. Ali, K. Maclellan, M. Moore, J. Wheeler, S. E. Harding, R. A. Fleck, J. M. Rowlinson, N. Kraenkel, R. Ascione, P. Madeddu, J. F. O'sullivan, A. L. Leblond, G. Kelly, A. H. S. Kumar, P. Metharom, C. K. Buneker, N. Alizadeh-Vikali, B. G. Hynes, R. O'connor, N. M. Caplice, M. Noseda, A. J. De Smith, T. Leja, P. H. Rao, F. Al-Beidh, M. S. Abreu Pavia, A. I. Blakemore, M. D. Schneider, K. Stathopoulou, F. Cuello, E. Ehler, R. S. Haworth, M. Avkiran, H. Morawietz, C. Eickholt, H. Langbein, M. Brux, C. Goettsch, W. Goettsch, A. Arsov, C. Brunssen, L. Mazilu, I. R. Parepa, A. I. Suceveanu, A. P. Suceveanu, F. S. De Man, C. Guignabert, L. Tu, M. L. Handoko, I. Schalij, E. Fadel, P. E. Postmus, A. Vonk-Noordegraaf, M. Humbert, S. Eddahibi, C. Del Giudice, A. Anastasio, L. Fazal, F. Azibani, N. Bihry, R. Merval, E. Polidano, J.-L. Samuel, C. Delcayre, Y. Zhang, Y. M. Mi, L. L. Ren, Y. P. Cheng, R. Guo, Y. Liu, Y. N. Jiang, A. D. Kokkinos, P. Tretjakovs, A. Jurka, I. Bormane, I. Mikelsone, D. Reihmane, K. Elksne, G. Krievina, J. Verbovenko, G. Bahs, N. Lopez-Andres, A. Rousseau, L. Calvier, R. Akhtar, C. Labat, K. Cruickshank, J. Diez, F. Zannad, P. Lacolley, P. Rossignol, K. Hamesch, P. Subramanian, X. Li, A. Thiemann, K. Heyll, K. Dembowsky, E. Chevalier, C. Weber, A. Schober, L. Yang, G. Kim, B. Gardner, J. Earley, M. Hofmann-Bowman, C.-F. Cheng, W.-S. Lian, H. Lin, N. J. Jinjolia, G. A. Abuladze, S. H. T. Tvalchrelidze, I. Khamnagadaev, M. Shkolnikova, L. Kokov, I. Miklashevich, I. Drozdov, I. Ilyich, B. O. Bingen, S. F. A. Askar, D. L. Ypey, A. Van Der Laarse, M. J. Schalij, D. A. Pijnappels, C. H. Roney, F. S. Ng, R. A. Chowdhury, E. T. Y. Chang, P. M. Patel, A. R. Lyon, J. H. Siggers, N. S. Peters, A. Obergrussberger, S. Stoelzle, A. Bruggemann, C. Haarmann, M. George, N. Fertig, D. Moreira, A. Souza, P. Valente, J. Kornej, C. Reihardt, J. Kosiuk, A. Arya, G. Hindricks, V. Adams, D. Husser, A. Bollmann, P. Camelliti, J. Dudhia, P. Dias, J. Cartledge, D. J. Connolly, M. Nobles, S. Sebastian, A. Tinker, A. Opel, H. Daimi, A. Haj Khelil, J. Be Chibani, A. Barana, I. Amoros, M. Gonzalez De La Fuente, R. Caballero, A. Aranega, A. Kelly, O. Bernus, O. J. Kemi, R. C. Myles, I. A. Ghouri, F. L. Burton, G. L. Smith, M. Del Lungo, L. Sartiani, V. Spinelli, M. Baruscotti, D. Difrancesco, A. Mugelli, E. Cerbai, A. M. Thomas, Q. Aziz, T. Khambra, J. M. A. Addlestone, E. J. Cartwright, R. Wilkinson, W. Song, S. Marston, A. Jacquet, N. M. Mougenot, A. J. Lipskaia, E. R. Paalberends, K. Stam, S. J. Van Dijk, M. Van Slegtenhorst, C. Dos Remedios, F. J. Ten Cate, M. Michels, H. W. M. Niessen, G. J. M. Stienen, J. Van Der Velden, M. I. Read, A. A. Andreianova, J. C. Harrison, C. S. Goulton, D. S. Kerr, I. A. Sammut, M. Wallner, D. Von Lewinski, D. Kindsvater, M. Saes, I. Morano, A. Muegge, B. Buyandelger, S. Kostin, S. Gunkel, J. Vouffo, K. Ng, J. Chen, M. Eilers, R. Isaacson, H. Milting, R. Knoell, M.-E. Cattin, C. Crocini, S. Schlossarek, S. Maron, A. Hansen, T. Eschenhagen, L. Carrier, G. Bonne, R. Coppini, C. Ferrantini, I. Olivotto, L. Belardinelli, C. Poggesi, M. C. Leung, A. E. Messer, O. Copeland, S. B. Marston, A. M. Mills, T. Collins, P. O'gara, T. Thum, K. Regalla, K. T. Macleod, T. Prodromakis, U. Chaudhry, A. Darzi, M. H. Yacoub, T. Athanasiou, A. Bogdanova, A. Makhro, M. Hoydal, T. O. Stolen, A. B. Johnssen, M. Alves, D. Catalucci, G. Condorelli, L. G. Koch, S. L. Britton, U. Wisloff, V. Bito, P. Claus, K. Vermeulen, C. Huysmans, R. Ventura-Clapier, K. R. Sipido, M. N. Seliuk, A. P. Burlaka, E. P. Sidorik, N. V. Khaitovych, M. M. Kozachok, V. S. Potaskalova, R. B. Driesen, D. T. Galan, D. De Paulis, T. Arnoux, S. Schaller, R. M. Pruss, D. M. Poitz, A. Augstein, R. C. Braun-Dullaeus, A. Schmeisser, R. H. Strasser, P. Micova, P. Balkova, M. Hlavackova, J. Zurmanova, D. Kasparova, F. Kolar, J. Neckar, F. Novak, O. Novakova, S. Pollard, M. Babba, A. Hussain, R. James, H. Maddock, A. S. Alshehri, G. F. Baxter, B. Dietel, R. Altendorf, W. G. Daniel, R. Kollmar, C. D. Garlichs, R. Sirohi, N. Roberts, D. Lawrence, A. Sheikh, S. Kolvekar, J. Yap, M. Arend, G. Walkinshaw, D. J. Hausenloy, D. M. Yellon, A. Posa, R. Szabo, Z. Szalai, P. Szablics, M. A. Berko, K. Orban, Z. S. Murlasits, L. Balogh, C. Varga, H. C. Ku, M. J. Su, R.-M. Chreih, C. Ginghina, D. Deleanu, A. L. B. J. Ferreira, A. Belal, M. A. Ali, X. Fan, A. Holt, R. Campbell, R. Schulz, C. Bonanad, V. Bodi, J. Sanchis, J. M. Morales, V. Marrachelli, J. Nunez, M. J. Forteza, F. Chaustre, C. Gomez, F. J. Chorro, T. Csont, V. Fekete, Z. Murlasits, E. Aypar, P. Bencsik, M. Sarkozy, Z. V. Varga, P. Ferdinandy, G. D. Duerr, M. Zoerlein, D. Dewald, B. Mesenholl, P. Schneider, A. Ghanem, S. Rittling, A. Welz, O. Dewald, E. Becker, C. Peigney, C. Bouleti, A. Galaup, C. Monnot, B. Ghaleh, S. Germain, A. Timmermans, A. Ginion, C. De Meester, K. Sakamoto, J.-L. Vanoverschelde, S. Horman, C. Beauloye, L. Bertrand, N. Maroz-Vadalazhskaya, E. Drozd, L. Kukharenko, I. Russkich, D. Krachak, Y. Seljun, Y. Ostrovski, A.-C. Martin, B. Le Bonniec, T. Lecompte, B. Dizier, J. Emmerich, A.-M. Fischer, C.-M. Samama, A. Godier, S. Mogensen, E. M. Furchtbauer, C. Aalkjaer, W. L. Choong, A. Jovanovic, F. Khan, J. M. Daniel, J. M. Dutzmann, R. Widmer-Teske, D. Guenduez, D. Sedding, M. M. Castro, J. J. C. Cena, W. J. C. Cho, G. G. Goobie, M. P. W. Walsh, R. S. Schulz, J. Dutzmann, K. T. Preissner, W. Sones, M. Kotlikoff, K. Serizawa, K. Yogo, K. Aizawa, M. Hirata, Y. Tashiro, N. Ishizuka, A. Varela, M. Katsiboulas, D. Tousoulis, T. G. Papaioannou, S. Vaina, C. H. Davos, C. Piperi, C. Stefanadis, E. K. Basdra, A. G. Papavassiliou, C. Hermenegildo, M. Lazaro-Franco, A. Sobrino, C. Bueno-Beti, N. Martinez-Gil, T. Walther, C. Peiro, C. F. Sanchez-Ferrer, S. Novella, M. Ciccarelli, A. Franco, G. W. Dorn, P. Cseplo, O. Torok, Z. S. Springo, Z. Vamos, D. Kosa, J. Hamar, A. Koller, K. J. Bubb, A. Ahluwalia, E. L. Stepien, A. Gruca, J. Grzybowska, J. Goralska, A. Dembinska-Kiec, J. Stolinski, L. Partyka, H. Zhang, D. Sweeney, G. N. Thomas, P. V. Fish, D. P. Taggart, S. Cioffi, M. Bilio, S. Martucciello, E. Illingworth, A. Caporali, S. Shantikumar, M. Marchetti, F. Martelli, C. Emanueli, M. Meloni, A. Al Haj Zen, G. Sala-Newby, S. Del Turco, C. Saponaro, B. Dario, S. Sartini, A. Menciassi, P. Dario, C. La Motta, G. Basta, V. Santiemma, C. Bertone, F. Rossi, E. Michelon, M. J. Bianco, A. Castelli, D. I. Shin, K. B. Seung, S. M. Seo, H. J. Park, P. J. Kim, S. H. Baek, Y. S. Choi, S. H. Her, D. B. Kim, J. M. Lee, C. S. Park, S. Rocchiccioli, A. Cecchettini, G. Pelosi, L. Citti, O. Parodi, M. G. Trivella, D. Michel-Monigadon, F. Burger, S. Dunoyer-Geindre, G. Pelli, B. Cravatt, S. Steffens, A. Didangelos, U. Mayr, X. Yin, C. Stegemann, J. Shalhoub, A. H. Davies, C. Monaco, M. Mayr, S. Lypovetska, S. Grytsenko, I. U. Njerve, A. A. Pettersen, T. B. Opstad, V. Bratseth, H. Arnesen, I. Seljeflot, I. E. Dumitriu, P. Baruah, R. F. Antunes, J. C. Kaski, I. Trapero, I. Benet, C. Alguero, F. J. Chaustre, A. Mangold, S. Puthenkalam, K. Distelmaier, C. Adlbrecht, I. M. Lang, T. Koizumi, I. Inoue, N. Komiyama, S. Nishimura, O. N. Korneeva, O. M. Drapkina, L. Fornai, A. Angelini, A. Kiss, F. Giskes, G. Eijkel, M. Fedrigo, M. L. Valente, G. Thiene, R. M. A. Heeren, T. Padro, L. Casani, R. Suades, B. Bertoni, R. Carminati, V. Carlini, L. Pettinari, C. Martinelli, N. Gagliano, G. Noppe, P. Buchlin, N. Marquet, N. Baeyens, N. Morel, A. Baysa, J. Sagave, C. P. Dahl, L. Gullestad, A. Carpi, F. Di Lisa, M. Giorgio, J. Vaage, G. Valen, E. Vafiadaki, V. Papalouka, G. Terzis, K. Spengos, P. Manta, C. Gales, G. Genet, E. Dague, O. Cazorla, B. Payre, C. Mias, A. Ouille, A. Lacampagne, A. Pathak, J. M. Senard, M. Abonnenc, P. Da Costa Martins, S. Srivastava, M. Gautel, L. De Windt, L. Comelli, C. Lande, N. Ucciferri, L. Ikonen, H. Vuorenpaa, K. Kujala, J.-R. Sarkanen, T. Heinonen, T. Ylikomi, K. Aalto-Setala, H. Capros, N. Sprincean, N. Usurelu, V. Egorov, N. Stratu, V. Matchkov, E. Bouzinova, N. Moeller-Nielsen, O. Wiborg, P. S. Gutierrez, R. Aparecida-Silva, L. F. Borges, L. F. P. Moreira, R. R. Dias, J. Kalil, N. A. G. Stolf, W. Zhou, K. Suntharalingam, N. Brand, R. Vilar Compte, L. Ying, K. Bicknell, A. Dannoura, P. Dash, G. Brooks, I. Tsimafeyeu, Y. Tishova, N. Wynn, I. P. Oyeyipo, L. A. Olatunji, L. Maegdefessel, J. Azuma, R. Toh, U. Raaz, D. R. Merk, A. Deng, J. M. Spin, P. S. Tsao, L. Tedeschi, M. Taranta, I. Naldi, S. Grimaldi, C. Cinti, M. Bousquenaud, F. Maskali, S. Poussier, P. Y. Marie, H. Boutley, G. Karcher, D. R. Wagner, Y. Devaux, I. Torre, S. Psilodimitrakopoulos, I. Iruretagoiena, A. Gonzalez-Tendero, D. Artigas, P. Loza-Alvarez, E. Gratacos, I. Amat-Roldan, L. Murray, D. M. Carberry, P. Dunton, M. J. Miles, M.-S. Suleiman, K. Kanesalingam, R. Taylor, C. N. Mc Collum, A. Parniczky, M. Solymar, A. Porpaczy, A. Miseta, Z. S. Lenkey, S. Szabados, A. Cziraki, J. Garai, I. Myloslavska, S. M. Menazza, M. C. Canton, F. D. L. Di Lisa, S. H. V. Oliveira, C. A. S. Morais, M. R. Miranda, T. T. Oliveira, M. R. A. Lamego, L. M. Lima, N. S. Goncharova, A. V. Naymushin, A. V. Kazimli, O. M. Moiseeva, M. G. Carvalho, A. P. Sabino, A. P. L. Mota, M. O. Sousa, A. Niessner, B. Richter, P. J. Hohensinner, K. Rychli, G. Zorn, R. Berger, D. Moertl, R. Pacher, J. Wojta, M. Huelsmann, G. Kukharchik, N. Nesterova, A. Pavlova, L. Gaykovaya, N. Krapivka, I. Konstantinova, L. Sichinava, S. Prapa, K. P. Mccarthy, P. J. Kilner, X. Y. Xu, M. R. Johnson, S. Y. Ho, M. A. Gatzoulis, E. G. Stoupel, R. Garcia, D. Merino, C. Montalvo, M. A. Hurle, J. F. Nistal, A. V. Villar, A. Perez-Moreno, R. Gilabert, and E. Ros
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medicine.medical_specialty ,Endocrinology ,Physiology ,Activator (genetics) ,Chemistry ,Physiology (medical) ,Internal medicine ,medicine ,AMPK ,Myocyte ,Long-term potentiation ,Metabolism ,Cardiology and Cardiovascular Medicine - Published
- 2012
4. AUTOMATIC CLUSTERING OF CELTIC COINS BASED ON 3D POINT CLOUD PATTERN ANALYSIS
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S. Horache, F. Goulette, J.-E. Deschaud, T. Lejars, and K. Gruel
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
The recognition and clustering of coins which have been struck by the same die is of interest for archeological studies. Nowadays, this work can only be performed by experts and is very tedious. In this paper, we propose a method to automatically cluster dies, based on 3D scans of coins. It is based on three steps: registration, comparison and graph-based clustering. Experimental results on 90 coins coming from a Celtic treasury from the II-Ith century BC show a clustering quality equivalent to expert’s work.
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- 2020
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- View/download PDF
5. P595PDGFRalpha demarcates the cardiogenic and clonogenic Sca-1+ stem cell
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S Mcsweeney, Schneider, Iain C. Macaulay, M Harada, T Leja, M Abreu Paiva, Sten Eirik W. Jacobsen, E Belian, M Noseda, and Mauricio Barahona
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CD31 ,Platelet-derived growth factor ,biology ,Physiology ,Clone (cell biology) ,Transplantation ,chemistry.chemical_compound ,Side population ,chemistry ,Physiology (medical) ,cardiovascular system ,Cancer research ,biology.protein ,Stem cell ,Cardiology and Cardiovascular Medicine ,Clonogenic assay ,Platelet-derived growth factor receptor - Abstract
Cardiac progenitor/stem cells in adult hearts are a potential mode of self-repair, therapeutic product, and target for activation in situ, though (inter)-relationships among reported cells remain obscure. Using single-cell qRT-PCR and clonal analyses, we define four sub-populations in adult mouse myocardium sharing stem cell antigen-1 (Sca1), based on side population (SP) phenotype, platelet/endothelial cell adhesion molecule 1 (CD31), and platelet derived growth factor receptor-α (PDGFRα). SP status predicted clonogenicity plus cardiogenic genes' expression (Gata4/6, Hand2, Tbx5/20), properties segregating more specifically to PDGFRα+ cells. PDGFRα- cells were characterized, instead, by Kdr/Flk1, Cdh5, CD31 and lack of clone formation. Clonal progeny of single Sca1+ SP cells showed tri-lineage potential (cardiomyocyte, endothelial, smooth muscle) after cardiac grafting. By fate-mapping, PDGFRα+ CD31- cells derived from cells formerly expressing Mesp1, Nkx2-5, Isl1, Gata5 and Wt1, distinct from PDGFRα- CD31+ cells (Gata5, Wt1 low; Flk1, Tie2 high). Thus, PDGFRα demarcates the clonogenic cardiogenic Sca-1+ stem cell.
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- 2014
6. Forward Programming of Cardiac Stem Cells by Homogeneous Transduction with MYOCD plus TBX5.
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Belian E, Noseda M, Abreu Paiva MS, Leja T, Sampson R, and Schneider MD
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- Animals, Cell Differentiation, Cells, Cultured, Doxycycline toxicity, Embryo, Mammalian metabolism, GATA4 Transcription Factor metabolism, Genetic Vectors metabolism, HEK293 Cells, Humans, Lentivirus genetics, MEF2 Transcription Factors metabolism, Male, Mice, Mice, Inbred C57BL, Myocardium metabolism, Nuclear Proteins genetics, Stem Cells cytology, Stem Cells drug effects, T-Box Domain Proteins genetics, Trans-Activators genetics, Transcription Factors metabolism, Cellular Reprogramming, Myocytes, Cardiac cytology, Nuclear Proteins metabolism, Stem Cells metabolism, T-Box Domain Proteins metabolism, Trans-Activators metabolism
- Abstract
Unlabelled: Adult cardiac stem cells (CSCs) express many endogenous cardiogenic transcription factors including members of the Gata, Hand, Mef2, and T-box family. Unlike its DNA-binding targets, Myocardin (Myocd)-a co-activator not only for serum response factor, but also for Gata4 and Tbx5-is not expressed in CSCs. We hypothesised that its absence was a limiting factor for reprogramming. Here, we sought to investigate the susceptibility of adult mouse Sca1+ side population CSCs to reprogramming by supplementing the triad of GATA4, MEF2C, and TBX5 (GMT), and more specifically by testing the effect of the missing co-activator, Myocd. Exogenous factors were expressed via doxycycline-inducible lentiviral vectors in various combinations. High throughput quantitative RT-PCR was used to test expression of 29 cardiac lineage markers two weeks post-induction. GMT induced more than half the analysed cardiac transcripts. However, no protein was detected for the induced sarcomeric genes Actc1, Myh6, and Myl2. Adding MYOCD to GMT affected only slightly the breadth and level of gene induction, but, importantly, triggered expression of all three proteins examined (α-cardiac actin, atrial natriuretic peptide, sarcomeric myosin heavy chains). MYOCD + TBX was the most effective pairwise combination in this system. In clonal derivatives homogenously expressing MYOCD + TBX at high levels, 93% of cardiac transcripts were up-regulated and all five proteins tested were visualized., In Summary: (1) GMT induced cardiac genes in CSCs, but not cardiac proteins under the conditions used. (2) Complementing GMT with MYOCD induced cardiac protein expression, indicating a more complete cardiac differentiation program. (3) Homogeneous transduction with MYOCD + TBX5 facilitated the identification of differentiating cells and the validation of this combinatorial reprogramming strategy. Together, these results highlight the pivotal importance of MYOCD in driving CSCs toward a cardiac muscle fate.
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- 2015
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7. PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium.
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Noseda M, Harada M, McSweeney S, Leja T, Belian E, Stuckey DJ, Abreu Paiva MS, Habib J, Macaulay I, de Smith AJ, al-Beidh F, Sampson R, Lumbers RT, Rao P, Harding SE, Blakemore AI, Jacobsen SE, Barahona M, and Schneider MD
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- Animals, Basic Helix-Loop-Helix Transcription Factors genetics, Cell Differentiation, Cell Lineage, Endothelial Cells cytology, Female, GATA4 Transcription Factor genetics, Gene Expression Regulation, Male, Mice, Mice, Inbred C57BL, Myocytes, Cardiac metabolism, Myocytes, Smooth Muscle cytology, Phenotype, Platelet Endothelial Cell Adhesion Molecule-1 metabolism, Principal Component Analysis, Regeneration, T-Box Domain Proteins genetics, Ataxin-1 metabolism, Myocardium metabolism, Receptor, Platelet-Derived Growth Factor alpha metabolism, Stem Cells cytology
- Abstract
Cardiac progenitor/stem cells in adult hearts represent an attractive therapeutic target for heart regeneration, though (inter)-relationships among reported cells remain obscure. Using single-cell qRT-PCR and clonal analyses, here we define four subpopulations of cardiac progenitor/stem cells in adult mouse myocardium all sharing stem cell antigen-1 (Sca1), based on side population (SP) phenotype, PECAM-1 (CD31) and platelet-derived growth factor receptor-α (PDGFRα) expression. SP status predicts clonogenicity and cardiogenic gene expression (Gata4/6, Hand2 and Tbx5/20), properties segregating more specifically to PDGFRα(+) cells. Clonal progeny of single Sca1(+) SP cells show cardiomyocyte, endothelial and smooth muscle lineage potential after cardiac grafting, augmenting cardiac function although durable engraftment is rare. PDGFRα(-) cells are characterized by Kdr/Flk1, Cdh5, CD31 and lack of clonogenicity. PDGFRα(+)/CD31(-) cells derive from cells formerly expressing Mesp1, Nkx2-5, Isl1, Gata5 and Wt1, distinct from PDGFRα(-)/CD31(+) cells (Gata5 low; Flk1 and Tie2 high). Thus, PDGFRα demarcates the clonogenic cardiogenic Sca1(+) stem/progenitor cell.
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- 2015
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8. Signaling via PI3K/FOXO1A pathway modulates formation and survival of human embryonic stem cell-derived endothelial cells.
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Merkely B, Gara E, Lendvai Z, Skopál J, Leja T, Zhou W, Kosztin A, Várady G, Mioulane M, Bagyura Z, Németh T, Harding SE, and Földes G
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- Animals, Cells, Cultured, Embryonic Stem Cells cytology, Forkhead Box Protein O1, Forkhead Transcription Factors genetics, Human Umbilical Vein Endothelial Cells cytology, Humans, Neovascularization, Physiologic, Phosphatidylinositol 3-Kinases genetics, Rats, Cell Differentiation, Embryonic Stem Cells metabolism, Forkhead Transcription Factors metabolism, Human Umbilical Vein Endothelial Cells metabolism, Phosphatidylinositol 3-Kinases metabolism, Signal Transduction
- Abstract
Vascular derivatives of human embryonic stem cells (hESC) are being developed as sources of tissue-specific cells for organ regeneration. However, identity of developmental pathways that modulate the specification of endothelial cells is not known yet. We studied phosphatidylinositol 3-kinase (PI3K)-Forkhead box O transcription factor 1A (FOXO1A) pathways during differentiation of hESC toward endothelial lineage and on proliferation, maturation, and cell death of hESC-derived endothelial cells (hESC-EC). During differentiation of hESC, expression of FOXO1A transcription factor was linked to the expression of a cluster of angiogenesis- and vascular remodeling-related genes. PI3K inhibitor LY294002 activated FOXO1A and induced formation of CD31(+) hESC-EC. In contrast, differentiating hESC with silenced FOXO1A by small interfering RNA (siRNA) showed lower mRNA levels of CD31 and angiopoietin2. LY294002 decreased proliferative activity of purified hESC-EC, while FOXO1A siRNA increased their proliferation. LY294002 inhibits migration and tube formation of hESC-EC; in contrast, FOXO1A siRNA increased in vitro tube formation activity of hESC-EC. After in vivo conditioning of cells in athymic nude rats, cells retain their low FOXO1A expression levels. PI3K/FOXO1A pathway is important for function and survival of hESC-EC and in the regulation of endothelial cell fate. Understanding these properties of hESC-EC may help in future applications for treatment of injured organs.
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- 2015
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9. Aberrant α-adrenergic hypertrophic response in cardiomyocytes from human induced pluripotent cells.
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Földes G, Matsa E, Kriston-Vizi J, Leja T, Amisten S, Kolker L, Kodagoda T, Dolatshad NF, Mioulane M, Vauchez K, Arányi T, Ketteler R, Schneider MD, Denning C, and Harding SE
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- Adrenergic alpha-Agonists pharmacology, Adrenergic beta-Agonists pharmacology, Adrenergic beta-Antagonists pharmacology, Cell Line, Embryonic Stem Cells cytology, Embryonic Stem Cells drug effects, Embryonic Stem Cells metabolism, Gene Expression drug effects, Humans, Hypertrophy, Imidazoles pharmacology, Induced Pluripotent Stem Cells cytology, Induced Pluripotent Stem Cells metabolism, Isoproterenol pharmacology, Microscopy, Confocal, Myocytes, Cardiac cytology, Myocytes, Cardiac metabolism, Phenylephrine pharmacology, Receptors, Adrenergic, alpha-1 genetics, Receptors, Adrenergic, alpha-1 metabolism, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction drug effects, Signal Transduction genetics, Adrenergic Agents pharmacology, Cell Size drug effects, Induced Pluripotent Stem Cells drug effects, Myocytes, Cardiac drug effects
- Abstract
Cardiomyocytes from human embryonic stem cells (hESC-CMs) and induced pluripotent stem cells (hiPSC-CMs) represent new models for drug discovery. Although hypertrophy is a high-priority target, we found that hiPSC-CMs were systematically unresponsive to hypertrophic signals such as the α-adrenoceptor (αAR) agonist phenylephrine (PE) compared to hESC-CMs. We investigated signaling at multiple levels to understand the underlying mechanism of this differential responsiveness. The expression of the normal α1AR gene, ADRA1A, was reversibly silenced during differentiation, accompanied by ADRA1B upregulation in either cell type. ADRA1B signaling was intact in hESC-CMs, but not in hiPSC-CMs. We observed an increased tonic activity of inhibitory kinase pathways in hiPSC-CMs, and inhibition of antihypertrophic kinases revealed hypertrophic increases. There is tonic suppression of cell growth in hiPSC-CMs, but not hESC-CMs, limiting their use in investigation of hypertrophic signaling. These data raise questions regarding the hiPSC-CM as a valid model for certain aspects of cardiac disease.
- Published
- 2014
- Full Text
- View/download PDF
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