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1. A parametric type of Bernoulli polynomials with higher level

Author: T. Komatsu
Subjects: bernoulli polynomials and numbers, recurrence relations, determinants, Mathematics, QA1-939
Abstract: In this paper, we introduce a parametric type of Bernoulli polynomials with higher level and study their characteristic and combinatorial properties. We also give determinant expressions of a parametric type of Bernoulli polynomials with higher level. The results are generalizations of those with level 2 by Masjed-Jamei, Beyki and Koepf and with level 3 by the author.
Published: 2022
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2. Asymmetric circular graph with Hosoya index and negative continued fractions

Author: T. Komatsu
Subjects: topological index, hosoya index, caterpillar-bond graph, negative continued fraction, non-uniform structure, cyclic graph, multidimensional continued fraction, radial crystal, Mathematics, QA1-939
Abstract: It has been known that the Hosoya index of caterpillar graph can be calculated as the numerator of the simple continued fraction. Recently in [MATCH Commun. Math. Comput. Chem. 2020, 84 (2), 399-428], the author introduces a more general graph called caterpillar-bond graph and shows that its Hosoya index can be calculated as the numerator of the general continued fraction. In this paper, we show how the Hosoya index of the graph with non-uniform ring structure can be calculated from the negative continued fraction. We also give the relation between some radial graphs and multidimensional continued fractions in the sense of the Hosoya index.
Published: 2021
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3. In-process monitoring of a tissue-engineered oral mucosa fabricated on a micropatterned collagen scaffold: use of optical coherence tomography for quality control

Author: O. Suebsamarn, Y. Kamimura, A. Suzuki, Y. Kodama, R. Mizuno, Y. Osawa, T. Komatsu, T. Sato, K. Haga, R. Kobayashi, E. Naito, M. Kida, K. Kishimoto, J. Mizuno, H. Hayasaki, and K. Izumi
Subjects: Picosecond laser machining, Biomimetics, Micropattern, Optical coherence tomography, Quality control, Tissue-engineered oral mucosa, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Background: We previously reported a novel technique for fabricating dermo-epidermal junction (DEJ)-like micropatterned collagen scaffolds to manufacture an ex vivo produced oral mucosa equivalent (EVPOME) for clinical translation; however, more biomimetic micropatterns are required to promote oral keratinocyte-based tissue engineering/regenerative medicine. In addition, in-process monitoring for quality control of tissue-engineered products is key to successful clinical outcomes. However, evaluating three-dimensional tissue-engineered constructs such as EVPOME is challenging. This study aimed to update our technique to fabricate a more biomimetic DEJ structure of oral mucosa and to investigate the efficacy of optical coherence tomography (OCT) in combination with deep learning for non-invasive EVPOME monitoring. Methods: A picosecond laser-textured microstructure mimicking DEJ on stainless steel was used as a negative mould to fabricate the micropatterned collagen scaffold. During EVPOME manufacturing, OCT was applied twice to monitor the EVPOME and evaluate its epithelial thickness. Findings: Our moulding system resulted in successful micropattern replication on the curved collagen scaffold. OCT imaging visualised the epithelial layer and the underlying micropatterned scaffold in EVPOME, enabling to non-invasively detect specific defects not found before the histological examination. Additionally, a gradual increase in epithelial thickness was observed over time. Conclusion: These findings demonstrate the feasibility of using a stainless-steel negative mould to create a more biomimetic micropattern on collagen scaffolds and the potential of OCT imaging for quality control in oral keratinocyte-based tissue engineering/regenerative medicine.
Published: 2022
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4. Three-dimensional strain evaluation of short-fiber-reinforced natural rubber using micro X-ray computed tomography

Author: M. Matsubara, S. Teramoto, T. Komatsu, S. Furuta, M. Kobayashi, S. Kawamura, A. Nagatani, N. Tsujiuchi, and A. Ito
Subjects: Damping material, Loss factor, Fiber orientation, X-ray tomography, 3D strain mapping, Polymers and polymer manufacture, TP1080-1185
Abstract: The vibration damping appears as a macroscopic material property due to the energy dissipation caused by the plastic deformation of the microstructure in the material, but the detailed mechanism is still unknown. This study prepared a damping material based on natural rubber (NR) and investigated its deformation behavior with/without fiber-shaped particles using synchrotron X-ray computed tomography (CT). High-resolution submicron X-ray CT was performed to evaluate the local strain in the microstructure from feature points scattered inside the NR. When the strain distribution changed under stepwise tensile loading, the NR-alone material deformed uniformly at the microscale, whereas the fiber composite rubber deformed nonuniformly. Furthermore, the number and volume of voids increased significantly with the compounding of fiber particles, and their values continued to increase depending on the strain amplitude and the loss factor. Controlling of non-uniform local strain and void formation will enable the design of damping characteristics.
Published: 2022
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5. CORAL REEFS ON INHABITED AND UNINHABITED SMALL ISLANDS, SPERMONDE ARCHIPELAGO, INDONESIA

Author: N. Nurdin, K. Amri, A. R. Rasyid, D. A. T. Pulubuhu, and T. Komatsu
Subjects: Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract: The small islands in Indonesia is providing important ecosystem services. It is important to identify damages of a coral reef ecosystem and whether natural factors or anthropogenic factors are the main causes. Landsat images obtained with different sensors were analyzed for mapping coral reef on inhabited and uninhabited small islands, Spermonde archipelago, Indonesia. Overall accuracies of three habitats classification were 89.2% and 85.6%, respectively. They are live coral, dead coral and non-coral. Ground truth surveys were selected by using the unsupervised classification method The live coral in inhabited islands was slightly greater than in uninhabited. An increasing area of live coral was about 5.3 ha of the total area in 1990 per year while a decreasing of dead coral was 3.5 ha per year in inhabited islands. In uninhabited island, a decreasing speed of live coral habitat area was about 0.6 per year. During 29 years, a significant increase in the dead coral and decrease in live corals. It has been identified that the significant controlling factor for the disturbances in reef ecosystem is derived from natural and anthropogenic.
Published: 2021
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6. ACCURACY OF UNSUPERVISED CLASSIFICATION TO DETERMINE CORAL HEALTH USING SPOT-6 AND SENTINEL-2A

Author: N. Nurdin, Supriadi, M. Lanuru, M. Akbar AS, I. Kartika, and T. Komatsu
Subjects: Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract: Characteristics of corals spectral from different species are expected to have optically different characters. The aims of this research are to compare unsupervised classification between IsoData and K-Means methods with Lyzenga application, and to analyze the precision of SPOT-6 and Sentinel-2A satellite imagery in classsifying shallow water habitat. The image processing are atmosferic correction, cropping, masking, Depth Invariant Index, Unsupervised classification, ground truthing, reclassify, accuracy assessment, and shallow water habitat spectral reflectance analysis. Rubble and dead coral with algae were indicating as coral death due to either damaging human activity or natural death such as bleaching. The accuracy of unsupervised classification IsoData and K-Means method have the same accuracy 62.50%. The IsoData method is better detected live coral and algae. Rubble were dominant detected in K-Means method.
Published: 2019
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7. Holocene ostracod assemblages from the Co To Islands, northeastern Vietnam

Author: S. Niiyama, G. Tanaka, T. Komatsu, H. D. Doan, H. B. Nguyen, H. T. Trinh, and M. T. Nguyen
Subjects: Geology, QE1-996.5
Abstract: In this study, we investigated ostracod assemblages from the Co To Islands in northeastern Vietnam. We identified 77 ostracod species belonging to 46 genera in nine surface sediment samples and recognized three biofacies (I, II, and III) based on Q-mode cluster analysis. The dominant species of biofacies I and II were Aurila hataii, Loxoconcha japonica, and Xestoleberis hanaii, which commonly occur in seaweed beds from southern China to Japan. This is the first report on the ostracod assemblage from the open-sea area in northeastern Vietnam. We clarified that the ostracod assemblages in the Gulf of Tongking, including northern Vietnam, have a strong biogeographical relationship with East Asia seas. A new species, Loxoconcha cotoensis sp. nov., was described herein from the Co To Islands (http://www.zoobank.org/NomenclaturalActs/41d3fb9f-ae17-4215-82c1-0874a8bf1a30, last access: 3 June 2019).
Published: 2019
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8. Multithreaded Algorithms for Lossless Intra Compression of Point Cloud Geometry Based on the Silhouette 3d Coder.

Author: Otho T. Komatsu, Edil Medeiros, Lucas M. Alves, and Eduardo Peixoto
Published: 2023
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9. Macro- and microhabitat use patterns of holothurians in Buena Vista, Nggela, Solomon Islands: rock climber and bottom crawler species

Author: I Tanita, EB Hirohavi, BA Diau, K Masaki, T Komatsu, and C Ramofafia
Subjects: Ecology, Aquatic Science, Ecology, Evolution, Behavior and Systematics
Abstract: Densities and habitat use patterns of holothurians, including nocturnal species, were assessed in Buena Vista, Nggela, Solomon Islands, for community-based resource management. Nighttime snorkeling surveys were conducted along transects (maximum 1.6 km) with 3 to 5 searchers in nearshore, channel, and outer reef macrohabitats. Only the population in the seagrass macrohabitat was separately assessed in 30 m line transects during the daytime. Microhabitats were clearly separated between species living on 3-dimensional structures (e.g. surfaces of knolls and reef slopes; rock climber group) and those on flat bottoms (bottom crawler group), although they coexisted at macrohabitat scales. Potential shelters adjacent to each individual differed between the 2 groups. Among bottom crawler species, Bohadschia koellikeri, which was recently taxonomically divided from B. vitiensis, occupied macrohabitats intermediately ranging between those of B. argus in the channel and outer reef macrohabitats and those of B. vitiensis and B. marmorata in the nearshore and seagrass macrohabitats. The high-density population was observed in the seagrass macrohabitat, mainly composed of Holothuria scabra, B. marmorata, and H. fuscogilva, although most individuals of these species were smaller than the national legal size limits. Moreover, the body lengths of H. atra and H. fuscogilva increased from the seagrass macrohabitat to the outer reef macrohabitat, implying their migration during growth and the roles of seagrass areas as nurseries. These results revealed diversity of macro- and microhabitat use patterns among species and their growth stages and highlight the importance of considering these factors for conserving diverse species by areal-based protection measures.
Published: 2022
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10. 1183 Expression of adhesion molecules and basic fibroblast growth factor 2 in non-segmental vitiligo-derived primary melanocytes

Author: T. Kawakami, Y. Dong, and T. Komatsu
Subjects: Cell Biology, Dermatology, Molecular Biology, Biochemistry
Published: 2023
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11. A ( p , q ) analogue of Poly-Euler polynomials and some related polynomials

Author: T. Komatsu, J. L. Ramírez, and V. F. Sirvent
Subjects: 010101 applied mathematics, 010102 general mathematics, 0101 mathematics, 01 natural sciences
Abstract: UDC 517.5 We introduce a ( p , q ) -analogue of the poly-Euler polynomials and numbers by using the ( p , q ) -polylogarithm function. These new sequences are generalizations of the poly-Euler numbers and polynomials. We give several combinatorial identities and properties of these new polynomials, and also show some relations with ( p , q ) -poly-Bernoulli polynomials and ( p , q ) -poly-Cauchy polynomials. The ( p , q ) -analogues generalize the well-known concept of the q -analogue.
Published: 2020
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12. Quality of correlating functions generated from commonly used basis sets.

Author: T. Komatsu, T. Noro, F. Sasaki, and H. Tatewaki
Published: 1996
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13. Impact of Blood Pressure Visit‐to‐Visit Variability on Adverse Events in Patients With Nonvalvular Atrial Fibrillation: Subanalysis of the J‐RHYTHM Registry

Author: Eitaro Kodani, Hiroshi Inoue, Hirotsugu Atarashi, Ken Okumura, Takeshi Yamashita, Toshiaki Otsuka, Hideki Origasa, H Inoue, K Okumura, H Atarashi, T Yamashita, M Sakurai, Y Kawamura, I Kubota, Y Kaneko, K Matsumoto, S Ogawa, Y Aizawa, I Kodama, E Watanabe, Y Koretsune, Y Okuyama, A Shimizu, O Igawa, S Bando, M Fukatani, T Saikawa, A Chishaki, H Origasa, N Kato, K. Kanda, J Kato, H Obata, M Aoki, H. Honda, Y Konta, T Hatayama, Y Abe, K Terata, T Yagi, A Ishida, T Komatsu, H Tachibana, H Suzuki, Y Kamiyama, T Watanabe, M Oguma, M Itoh, O Hirono, Y Tsunoda, K Ikeda, T Kanaya, K Sakurai, H Sukekawa, S Nakada, T Itoh, S Tange, M. Manita, M Ohta, H Eguma, R Kato, Y Endo, T Ogino, M Yamazaki, H Kanki, M Uchida, S Miyanaga, K Shibayama, N Toratani, T Kojima, M Ichikawa, M Saito, Y Umeda, T Sawanobori, H Sohara, S Okubo, T Okubo, T. Tokunaga, O Kuboyama, H Ito, Y Kitahara, K Sagara, T Satoh, E Kodani, K Sugi, Y Kobayashi, Y Higashi, T Katoh, Y Hirayama, N Matsumoto, M Takano, T Ikeda, S Yusu, S Niwano, Y Nakazato, Y Kawano, M Sumiyoshi, N Hagiwara, K Murasaki, H Mitamura, S Nakagawa, K Okishige, K Azegami, H Aoyagi, K Sugiyama, M Nishizaki, N Yamawake, I Watanabe, K Ohkubo, H Sakurada, S Fukamizu, M Suzuki, W Nagahori, T Nakamura, Y Murakawa, N Hayami, K Yoshioka, M Amino, K Hirao, A Yagishita, K Ajiki, K Fujiu, Y Imai, A Yamashina, T Ishiyama, M Sakabe, K Nishida, H Asanoi, H Ueno, null Lee, Y Mitsuke, H Furushima, K Ebe, M Tagawa, M Sato, M. Morikawa, K Yamashiro, K Takami, T Ozawa, M Watarai, M Yamauchi, H Kamiya, H. Hirayama, Y. Yoshida, T Murohara, Y Inden, H Osanai, N Ohte, T Goto, I Morishima, T Yamamoto, E Fujii, M Senga, H. Hayashi, T Urushida, Y Takada, N Tsuboi, T Noda, T Hirose, T Onodera, S Kageyama, T Osaka, T. Tomita, K Shimada, M Nomura, H Izawa, A Sugiura, T Arakawa, K. Kimura, T Mine, T Makita, H Mizuno, A Kobori, T Haruna, M Takagi, N Tanaka, H Shimizu, T Kurita, K Motoki, N Takeda, Y Kijima, M Ito, A Nakata, Y Ueda, A Hirata, S Kamakura, K Satomi, Y. Yamada, Y. Yoshiga, H Ogawa, M Kimura, T Hayano, T Kinbara, H Tatsuno, M Harada, K. Kusano, M Adachi, A Yano, M Sawaguchi, J Yamasaki, T Matsuura, Y Tanaka, H Moritani, T Maki, S Okada, M Takechi, T Hamada, A Nishikado, Y Takagi, I Matsumoto, T Soeki, Y Doi, M Okawa, H Seo, S Kitamura, K Yamamoto, M Akizawa, N Kaname, S Ando, S Narita, T Inou, Y Fukuizumi, K Saku, M Ogawa, Y Urabe, M Ikeuchi, S Harada, H Yamabe, Y Imamura, Y. Yamanouchi, K Sadamatsu, K Yoshida, T Kubota, N Takahashi, N Makino, Y Higuchi, T Ooie, T Iwao, K. Kitamura, T Imamura, K Maemura, N Komiya, M Hayano, H Yoshida, and K. Kumagai
Subjects: Male, medicine.medical_specialty, Hemorrhage, Risk Assessment, Rhythm, Japan, Risk Factors, Cause of Death, Thromboembolism, Internal medicine, Atrial Fibrillation, Ambulatory Care, medicine, Humans, Arrhythmia and Electrophysiology, In patient, Registries, Risk factor, Adverse effect, Original Research, Aged, Analysis of Variance, variability, Clinical events, business.industry, blood pressure, Anticoagulants, Blood Pressure Determination, Atrial fibrillation, medicine.disease, Blood pressure, major hemorrhage, Hypertension, Cardiology, Female, Warfarin, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors
Abstract: Background Blood pressure (BP) variability has reportedly been a risk factor for various clinical events. To clarify the influence of BP visit‐to‐visit variability on adverse events in patients with nonvalvular atrial fibrillation, a post hoc analysis of the J‐RHYTHM Registry was performed. Methods and Results Of 7406 outpatients with nonvalvular atrial fibrillation from 158 institutions, 7226 (age, 69.7±9.9 years; men, 70.7%), in whom BP was measured 4 times or more (14.6±5.0 times) during the 2‐year follow‐up period or until occurrence of an event, constituted the study group. SD and coefficient of variation of BP values were calculated as BP variability. Thromboembolism, major hemorrhage, and all‐cause death occurred in 110 (1.5%), 121 (1.7%), and 168 (2.3%) patients, respectively. When patients were divided into quartiles of systolic BP‐SD (P =0.015 for thromboembolism; HR, 2.60, 95% CI, 1.36–4.97, P =0.004 for major hemorrhage; and HR, 1.85, 95% CI, 1.11–3.07, P =0.018 for all‐cause death) after adjusting for components of the CHA 2 DS 2 ‐VASc score, warfarin and antiplatelet use, atrial fibrillation type, BP measurement times, and others. These findings were consistent when BP‐coefficient of variation was used instead of BP‐SD. Conclusions Systolic BP visit‐to‐visit variability was significantly associated with all adverse events in patients with nonvalvular atrial fibrillation. Further studies are needed to clarify the causality between BP variability and adverse outcomes in patients with nonvalvular atrial fibrillation. Registration URL: https://www.umin.ac.jp/ctr/ ; Unique Identifier: UMIN000001569.
Published: 2021
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14. X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

Author: S. Abiru, John F. Dillon, Yasuhiro Miyake, Piero Portincasa, Giancarlo Spinzi, R. Harvey, T. Ngatchu, Agostino Colli, M. Taniai, K. Flahive, Masanori Abe, B. Hoeroldt, S. Holder, Howard Curtis, María Isabel Colombo, C. MacNicol, Gang Xie, Andrew Chilton, H. Hussaini, Cristina Rigamonti, M. Kato, Shintaro Yagi, G. Abouda, D. Tyrer, Chris D. Evans, Christopher I. Amos, K. Koss, Kazuaki Chayama, P. Premchand, K. Migita, Simon Panter, Marco Marzioni, Silvia Colombo, Konstantinos N. Lazaridis, M. Yagura, Ashley Brown, D. Gocher, Domenico Alvaro, K. Murata, Mark Wright, Piero Luigi Almasio, C. Healey, A. Ciaccio, N. Wheatley, Vincenzo Cardinale, T. Delahooke, Chiara Milani, T. Shewan, W. Stableforth, S. Levi, Mark L. Green, James V. Jones, Y. Baird, Aftab Ala, Burroughs Ak, D. Williams, K. Ario, P. Sanghi, Hemant Gupta, P. Southern, L. Farrington, M. Hamilton, Andrew D. Higham, I. Yabuuchi, H. Yatsuhashi, Lorenzo Morini, T. Yamamoto, Douglas Thorburn, M. Carnahan, N. Nishida, Susan Slininger, M. Koga, K. Honda, Annarosa Floreani, Andrew Douglass, K. Netherton, M. Yasunami, Hirohito Tsubouchi, F. Donato, K. Walker, U. Shmueli, Paolo Muratori, Ray Mathew, J. Maiden, E. Dungca, Subramaniam Ramakrishnan, S. Vyas, Helen Sweeting, Subrata Saha, T. Komeda, T. Komatsu, H. J. Lee, Maria Consiglia Bragazzi, T. Komura, C. Thomas, C. Shallcross, C. Duggan, J. Kordula, F. Muscariu, Lourdes Cumlat, Imran Patanwala, Giulia Cardamone, L. Morgan, J. Brighton, Masao Honda, H. Nakamura, David Jones, Raj Srirajaskanthan, M. E. Gershwin, T. Muro, L. Stafford, N. Fukushima, Graham P. Butcher, Andrea Crosignani, George Lipscomb, K. Hirata, Y. Nagaoki, S. Mann, Paul G. Richardson, David A Elphick, M. Mupudzi, Y. Ohara, E. Grieve, Gayle Clifford, Claudio Tiribelli, M. Quinn, G. Van Duyvenvoorde, E. Archer, Tatsuki Ichikawa, J. Maltby, T. Arinaga-Hino, Simon Williams, A. King, Yasuni Nakanuma, H. Doyle, A. Brind, Nora Cazzagon, H. Ota, Daphne D’Amato, K. Hogben, H. Wooldridge, J. Wilkins, Shuichi Kaneko, L. Hankey, Gordon Wood, Andrew Fraser, K. Martin, A. Naqvi, M. Ninkovic, M. Patel, Yoshihiko Maehara, Kapil Kapur, I. Amey, Vincenza Calvaruso, Kenichi Harada, T. Yamashita, James Neuberger, N. Taylor, T. Lee, J. Featherstone, C. Lawlor, K. Seward, Satoshi Yamagiwa, Andrea Galli, L. Tan, Kentaro Kikuchi, K. Furuta, Mark A. Ainsworth, Hiromasa Ohira, Esther Unitt, Yosuke Kawai, N. Lancaster, D. Simpson, R. Shidrawi, I. Salam, A.J. Bell, Pietro Andreone, J. Ishida, Voi Shim Wong, N Fisher, Andrew C. Douds, R. Penn, Matthew Foxton, A. Watson, Andrew Mason, S. Walsh, Hiromi Ishibashi, Daniel M. Forton, Giovanni Casella, H. Takaki, K. Yamauchi, Pietro Lampertico, Osamu Yokosuka, M. Koda, M. Davies, H. Mitchison, P. Gyawali, G. Bird, M. Hughes, L. Jones, C. Hamilton, A. Hynes, R. Galaska, Fabio Marra, Debasish Das, C. Cowley, A. Fouracres, Yasuhiko Sugawara, E. Mita, T. Saoshiro, Akinobu Taketomi, Robert P. Myers, R. Przemioslo, F. Wright, L. Hobson, L. Currie, J. Allison, J. Hails, Noriyo Yamashiki, Massimo Zuin, C. Grimley, Alessio Gerussi, S. Besley, Stefano Duga, A. Piotrowicz, H. Kouno, L. Dali-kemmery, H. Sakai, M. Mizokami, Stefano Fagiuoli, Amy Davis, Pier Maria Battezzati, Masao Nagasaki, Luigi Muratori, A. Mori, S. Desmennu, S. Jones, R. Abrahams, Keith George, F. Makita, J. Brown, D. Gorard, Satoru Joshita, M. Mills, Pierluigi Toniutto, S. Campbell, J. Butterworth, S. Dyer, Filomena Morisco, Norihiro Kokudo, T. Yapp, C. Shorrock, Floriano Rosina, E. Walker, Shinji Uemoto, H. Takahashi, Simon M. Rushbrook, K. Amor, E. Marshall, J. Browning, S. Batham, Luca Fabris, Paul R. Banim, Meenakshi Narain, M. Harada, Dermot Gleeson, N. Hirashima, M. Kikuchi, T. Nikami, Gideon M. Hirschfield, Carlo Ferrari, G. Prasad, O. Chirag, Katsushi Tokunaga, M. Nasseri, Rosanna Asselta, Y. Lu, Ken Shirabe, D. Sirdefield, George F. Mells, K. Sugi, R. Ayres, G. Whatley, A. Singhal, M. Leoni, N. Sivaramakrishnan, T. Harding, Rupert Ransford, Anton V J Gunasekera, C. Mulvaney-Jones, D. Ramanaden, M. Mendall, Muhammad F. Dawwas, Dave Jones, Luca Valenti, Earl J. Williams, Markus Gess, Peter Bramley, A. McNair, E. Hashimoto, P. Townshend, C. Ford, Mario Strazzabosco, Luca Miele, Matthew J Brookes, J. Colley, Mark Wilkinson, H. Dewhurst, Charles Millson, E. Shpuza, Shinji Shimoda, T. Himoto, P. Kitchen, M. Nakamuta, Hiroaki Nishimura, Martin Lombard, Kevork M. Peltekian, M. Pitcher, G. Lim, L. Graves, C. Palmer, S. Lord, S. Katsushima, S. Tripoli, Andrew Austin, N. White, B. Grover, S. Congreave, M. Prince, Rebecca Jones, K. Hirano, A. Shepherd, Y. Mano, Michael A. Heneghan, Richard Sandford, L. O'Donohoe, Marco Carbone, S. A. Rolls, Patrick Goggin, M. L. Cowan, M. Crossey, A. Loftus, K. Young, Mesbah Rahman, Cameron N. Ghent, E. Nambela, M. Xiong, L. Grellier, Sunil Dolwani, Antonio Picciotto, Gill Watts, Alberto Mattalia, Elvezia Maria Paraboschi, J. Orpe, Takeji Umemura, Yuki Hitomi, Fiona H. Gordon, Shotaro Sakisaka, A. Dias, Chin Lye Ch'ng, M. Carter, A. Mandal, Yufang Shi, Takafumi Ichida, N. Masaki, M. Oblak, S. Nagaoka, Kevin Yoong, O. Gervais, Minoru Nakamura, Kazuhiko Nakao, S. Taylor-Robinson, L. Kent, Sushma Saksena, A. Affronti, K. Boulton, R. Ede, H. Pateman, K. Yoshizawa, G. Bray, H. Ebinuma, Yeng Ang, Akio Ido, John Ramage, Richard Sturgess, C. Gray, E. Durant, M. Hayes, A. Saeed, J. Keggans, J. Gitahi, T. Valliani, Edoardo G. Giannini, C. Foale, A. Palegwala, Lory Saveria Crocè, K. Matsushita, S. Shaukat, J. Mclindon, S. Pearson, A. Barnardo, A. Wright, Mirko Tarocchi, R Marley, M. Kent, C. Dickson, A. Gibbins, J. Whiteman, S. Singhal, Richard Aspinall, M. Ito, Laura Cristoferi, Maurizia Rossana Brunetto, J. Booth, A. Bathgate, Morikazu Onji, A. Grant, A. Paton, Y. Aiba, P. Chan, J. Sayer, S. Whalley, T. Mathialahan, J. Gotto, T. Kanda, B. Williams, K. Elliott, P. Raymode, Akinobu Takaki, V. Silvestre, I. Gee, C. Hovell, Graham R. Foster, D. Cotterill, G. Stansfield, Grazia Anna Niro, J. Conder, Yoshiyuki Ueno, A. Shah, Jane Metcalf, S. Hayashi, T. Sato, S. Jain, J. Subhani, Donatella Barisani, A. McKay, Kuniaki Arai, Jeremy Shearman, Torao Tanaka, S. Glenn, S. E. O'Donnell, Federica Malinverno, Denise O'Donnell, R. Casey, N. Sharer, J. Bowles, J. Kendall, Maria Cristina Vinci, Antonio Benedetti, George MacFaul, K. Houghton, Vincenzo Ronca, P. Desousa, B. Holbrook, F. Ali, B. Longhurst, Atsushi Tanaka, Marek Czajkowski, R. Tang, Kazuhide Yamamoto, Y. Watanabe, Graeme J.M. Alexander, R. Cloudsdale, F. Hines, M. Karmo, Brian D. Juran, I. Gooding, Y. Takeyama, J. Fraser, A. Mukhopadhya, Sumihito Tamura, Hajime Takikawa, R. Damant, E. Wilhelmsen, M. Kobayashi, J. Tregonning, V. Lambourne, D. Clement, D. Braim, M. Shimada, S. Sen, Shaun Greer, C. Innes, E. Gunter, C. Brown, H. Klass, A. Komori, Andy Li, H. Fairlamb, N. Ncube, Yoshinori Shimada, M. Harrison, S. Marriott, I. Grattagliano, Savino Bruno, A. Naganuma, Xiangjun Gu, Michael F. Seldin, S. Thornthwaite, Peter R. Mills, Katherine A. Siminovitch, X. Liu, Masataka Seike, J. Curtis, Carmela Cursaro, Z. Li, Mikio Zeniya, K. Warner, B. Bird, Jane Collier, Bridget Gunson, S. Tsuruta, E. Tanqueray, Richard Evans, H. Kamitsukasa, R. Sugimoto, Jeremy Tibble, D. Neal, S. Ducker, Francesco Azzaroli, K. Spurdle, K. Ocker, M. Senju, C. Collins, Y. Nakamura, Matthew E. Cramp, Yuji Soejima, I. Drake, K. Ueno, T. Mannami, Clara Mancuso, M. Kawashima, M. Cox, S. S. Kohn, H. Shibata, Stephen D. Ryder, Christopher Macdonald, J. Ridpath, Stephen P. Pereira, L. March, Barbara Coco, J. Morrison, A. Broad, J. Verheyden, Angelo Andriulli, N. Higuchi, J. Musselwhite, R. Bishop, Gwen Baxter, Richard A. Miller, Guido Colloredo, A. Eastick, I. Rees, Deb Ghosh, L. Winter, Sara Massironi, R. McCorry, Gianfranco Elia, T. Kobata, N. Naeshiro, K. Pollock, J. Gasem, S. Gallagher, K. Jing, S. Misra, B. Shinder, Harriet Gordon, E. Takesaki, J. Sadeghian, S. Tsunematsu, Ana Lleo, M. 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L., Rahman, M., Yapp, T., Sturgess, R., Healey, C., Czajkowski, M., Gunasekera, A., Gyawali, P., Premchand, P., Kapur, K., Marley, R., Foster, G., Watson, A., Dias, A., Subhani, J., Harvey, R., Mccorry, R., Ramanaden, D., Gasem, J., Evans, R., Mathialahan, T., Shorrock, C., Lipscomb, G., Southern, P., Tibble, J., Gorard, D., Palegwala, A., Jones, S., Dawwas, M., Alexander, G., Dolwani, S., Prince, M., Foxton, M., Elphick, D., Mitchison, H., Gooding, I., Karmo, M., Saksena, S., Mendall, M., Patel, M., Ede, R., Austin, A., Sayer, J., Hankey, L., Hovell, C., Fisher, N., Carter, M., Koss, K., Piotrowicz, A., Grimley, C., Neal, D., Lim, G., Levi, S., Ala, A., Broad, A., Saeed, A., Wood, G., Brown, J., Wilkinson, M., Gordon, H., Ramage, J., Ridpath, J., Ngatchu, T., Grover, B., Shaukat, S., Shidrawi, R., Abouda, G., Ali, F., Rees, I., Salam, I., Narain, M., Brown, A., Taylor-Robinson, S., Williams, S., Grellier, L., Banim, P., Das, D., Chilton, A., Heneghan, M., Curtis, H., Gess, M., Drake, I., Aldersley, M., Davies, M., Jones, R., Mcnair, A., Srirajaskanthan, R., Pitcher, M., Sen, S., Bird, G., Barnardo, A., Kitchen, P., Yoong, K., Chirag, O., Sivaramakrishnan, N., Macfaul, G., Jones, D., Shah, A., Evans, C., Saha, S., Pollock, K., Bramley, P., Mukhopadhya, A., Fraser, A., Mills, P., Shallcross, C., Campbell, S., Bathgate, A., Shepherd, A., Dillon, J., Rushbrook, S., Przemioslo, R., Macdonald, C., Metcalf, J., Shmueli, U., Davis, A., Naqvi, A., Lee, T., Ryder, S. D., Collier, J., Klass, H., Ninkovic, M., Cramp, M., Sharer, N., Aspinall, R., Goggin, P., Ghosh, D., Douds, A., Hoeroldt, B., Booth, J., Williams, E., Hussaini, H., Stableforth, W., Ayres, R., Thorburn, D., Marshall, E., Burroughs, A., Mann, S., Lombard, M., Richardson, P., Patanwala, I., Maltby, J., Brookes, M., Mathew, R., Vyas, S., Singhal, S., Gleeson, D., Misra, S., Butterworth, J., George, K., Harding, T., Douglass, A., Panter, S., Shearman, J., Bray, G., Butcher, G., Forton, D., Mclindon, J., Cowan, M., Whatley, G., Mandal, A., Gupta, H., Sanghi, P., Jain, S., Pereira, S., Prasad, G., Watts, G., Wright, M., Neuberger, J., Gordon, F., Unitt, E., Grant, A., Delahooke, T., Higham, A., Brind, A., Cox, M., Ramakrishnan, S., King, A., Collins, C., Whalley, S., Li, A., Fraser, J., Bell, A., Wong, V. 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Picciotto, A, Morisco, F, Fabris, L, Croce, L, Tiribelli, C, Toniutto, P, Strazzabosco, M, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Dawwas, M, Alexander, G, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Taylor-Robinson, S, Williams, S, Grellier, L, Banim, P, Das, D, Chilton, A, Heneghan, M, Curtis, H, Gess, M, Drake, I, Aldersley, M, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Bathgate, A, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Thorburn, D, Marshall, E, Burroughs, A, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Neuberger, J, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney-Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Williams, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, O'Donnell, D, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali-kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, O'Donohoe, L, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, Kordula, J, Aiba, Y, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Kawai, Y, Kohn, S, Gervais, O, Migita, K, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Higuchi, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Takikawa, H, Ohira, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Carbone, M, Cardamone, G, Duga, S, Gershwin, M, Seldin, M, Invernizzi, P, Asselta R, Paraboschi EM, Gerussi A, Cordell HJ, Mells GF, Sandford RN, Jones DE, Nakamura M, Ueno K, Hitomi Y, Kawashima M, Nishida N, Tokunaga K, Nagasaki M, Tanaka A, Tang R, Li Z, Shi Y, Liu X, Xiong M, Hirschfield G, Siminovitch KA, Canadian-US PBC Consortium, Italian PBC Genetics Study Group, UK-PBC Consortium, Japan PBC-GWAS Consortium, Carbone M, Cardamone G, Duga S, Gershwin ME, Seldin MF, Invernizzi P, and LiveR North
Subjects: Canadian-US PBC Consortium, 0301 basic medicine, Male, Linkage disequilibrium, Genome-wide association study, Disease, PBC, Settore MED/03 - GENETICA MEDICA, Linkage Disequilibrium, 0302 clinical medicine, UK-PBC Consortium, Genotype, Mitochondrial Precursor Protein Import Complex Proteins, Italian PBC Genetics Study Group, Odds Ratio, X-Wide Association Study, Japan PBC-GWAS Consortium, X chromosome, Genetics, Liver Cirrhosis, Biliary, Gastroenterology, Forkhead Transcription Factors, DNA-Binding Proteins, Shal Potassium Channels, 030211 gastroenterology & hepatology, Female, Adult, Monosaccharide Transport Proteins, Superenhancer, Locus (genetics), Single-nucleotide polymorphism, Biology, Protein Serine-Threonine Kinases, Polymorphism, Single Nucleotide, Article, White People, 03 medical and health sciences, Asian People, Proto-Oncogene Proteins, Endopeptidases, Humans, Cell Lineage, Genetic Predisposition to Disease, Meta-analysi, Genetic association, Chromosomes, Human, X, Gastroenterology & Hepatology, Hepatology, 1103 Clinical Sciences, Meta-analysis, 030104 developmental biology, Genetic Loci, 1114 Paediatrics and Reproductive Medicine, 1109 Neurosciences, Carrier Proteins, Genome-Wide Association Study
Abstract: Background & aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10-4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10-6; odds ratio [OR], 1.39; 95% confidence interval [CI], 1.028-1.88; Japanese cohort). Although the transethnic meta-analysis evidenced only a suggestive signal (rs2239452, mapping within the PIM2 gene; OR, 1.17; 95% CI, 1.09-1.26; P = 9.93 × 10-8), the population-specific meta-analysis showed a genome-wide significant locus in East Asian individuals pointing to the same region (rs7059064, mapping within the GRIPAP1 gene; P = 6.2 × 10-9; OR, 1.33; 95% CI, 1.21-1.46). Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP3, the main T-regulatory cell lineage specification factor. Consistently, OTUD5 and FOXP3 RNA levels were up-regulated in PBC case patients (1.75- and 1.64-fold, respectively). Conclusions: This work represents the first comprehensive study, to our knowledge, of the chrX contribution to the genetics of an autoimmune liver disease and shows a novel PBC-related genome-wide significant locus.
Published: 2021

15. Implementing social innovation in real contexts

Author: Alessandro Deserti, Francesca Rizzo, and T. T. Komatsu
Subjects: Information Systems and Management, Knowledge management, business.industry, Process (engineering), Strategy and Management, Flourishing, Design thinking, Social innovation, Social issues, Ideal (ethics), Innovation processes, Management of Technology and Innovation, Participatory design, participatory design, business, Empirical evidence, Context dependency, Open innovation
Abstract: Increasing attention is being paid towards the potential of social innovation in responding to society's greatest challenges. While measures have been taken to support the flourishing of these innovations, they have thus far been made on ideal models of development, misaligned with what occurs in reality. This has led to the creation of supporting infrastructures that fail to respond to social innovators real needs. The paper seeks to provide a picture of the real social innovation development process through a case-based discussion coming from the results of, SIMPACT, a recently EU research project. The research demonstrates how SI actually takes place in constrained contexts and typically develops as a frugal answer to a social problem. The paper offers substantial empirical evidence that a support system is fundamental in making. SI thrive, thus providing relevant insights and guidance for policy making, with particular emphasis on the concept of SI ecosystems.
Published: 2020

16. Variation of tensile and bending rigidities of a duplex embossed steel sheet by small uniaxial tensile deformation

Author: Y. Suzuki, W.Y. Liu, T. Shiratori, T. Komatsu, and Takashi Iizuka
Subjects: Materials science, 020502 materials, Metals and Alloys, Uniaxial tension, Flexural rigidity, 02 engineering and technology, Industrial and Manufacturing Engineering, Computer Science::Other, Computer Science Applications, 020303 mechanical engineering & transports, Rigidity (electromagnetism), 0205 materials engineering, 0203 mechanical engineering, Deflection (engineering), Modeling and Simulation, visual_art, Ultimate tensile strength, Ceramics and Composites, visual_art.visual_art_medium, Deformation (engineering), Composite material, Sheet metal, Embossing
Abstract: Materials which have periodic macroscopic structure have some potential for becoming an advanced method to enhance the mechanical properties of sheet metal which will be applied to automotive parts and architecture. This structure, achieved here by embossing sheet metal, could improve mechanical features, especially bending rigidity. In addition to the microscopic aggregate structure, periodic configurations given by embossing bring about new quasi-uniform “apparent” macroscopic properties. When an embossed sheet is subjected to plastic deformation, the new shape would include these apparent mechanical properties. In this study, uniaxial tensile tests and bending tests of duplex embossed sheets, which have periodic convexities and concavities, were conducted experimentally and analytically respectively. And tensile rigidity and bending rigidity were evaluated by changing the embossing height and direction. The variation of these rigidities with different preliminary small uniaxial tensile deformations (pre-strains) was also investigated. The results confirmed that the tensile rigidity of embossed sheets with larger embossing height was lower than that of sheets with smaller embossing height. However, when preliminary tensile deformation was added, the tensile and bending rigidity increased. On the other hand, the bending rigidity of embossed sheets with larger embossing height was considerably higher than that of sheets with smaller embossing height. The degree of these tendencies varied depending on the embossing direction. Furthermore, from analytical results, the evaluation method which was used apparent geometry in this study, it is suitable to evaluate duplex embossed sheets due to it includes local rotating and bending deformation are accompanied with the plastic deformation. Also, it is considered that the apparent bending rigidity is a comprehensive value which can express more realistic macroscopic deflection behavior of embossed sheet.
Published: 2018
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17. Summer production of high soluble solid content tomato by the simple and low-cost nutriculture system in Hokkaido

Author: T. Komatsu, S. Yasuoka, and T. Jishi
Subjects: Horticulture, Brix, Nutrient solution, Geography, Soluble solids, Water stress, Greenhouse, Salinity stress, Japanese market, Water deficit
Abstract: Tomatoes with Brix >8% are classified as high soluble solid content (SSC) fruits and are regarded as one of the more expensive vegetables in the Japanese market. These fruits are commonly produced by imposing some kind of stress, such as water stress (water deficit) or, salinity stress (high-level electrical conductivity) on plants. Summer is the off-season for high SSC tomatoes in the main production areas of Japan. These areas have a mild climate and they can experience high temperatures, therefore, inhibiting the ability to attain the precise stress controls needed for production of these valuable fruits. Hokkaido is the northernmost island of Japan and has a cool climate in summer. In this study, in order to explore the potential of establishing summer production of high SSC tomatoes in Hokkaido, we produced tomatoes using a simple and low cost nutriculture system with a nutrient solution containing sodium chloride (NaCl) in plastic greenhouses during 2013 and 2014. By applying 0-600 mL of nutrient solution adjusted to an electric conductivity (EC) of 3.0-4.0 dS m-1 to each plant cultivated in 21 cm diameter plastic pots every day, we were able to constantly harvest tomato fruits with Brix values higher than 8% from the 1st to the 5th truss throughout the experimental period in both years. Those with marketable yields (793 g plant-1 in 2013 and 611 g plant-1 in 2014) were sufficient for commercial production. These results suggest that it is possible to produce high SSC tomatoes in summer by using a simple and low-cost nutriculture system in a plastic greenhouse in Hokkaido.
Published: 2017
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18. Establishment and Activities of a Swallowing Support Team at Our Hospital

Author: H. Irisawa, K. Goto, T. Mikogai, Y. Abe, K. Oshida, I. Aoki, T. Komatsu, K. Shimizu, and T. Mizushima
Subjects: medicine.medical_specialty, Swallowing, business.industry, Physical therapy, Medicine, business
Published: 2020
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19. Determination of perillaldehyde in perilla herbs based on relative molar sensitivity (RMS) using a combination of 1H-quantitative NMR and HPLC/UV

Author: J Hosoe, T Suematsu, N Uchiyama, Taro Higano, N Sugimoto, Y Igarashi, Y Yamada, Takuro Maruyama, K Mizui, T Miura, N Shimada, S Takaoka, N Masumoto, T Komatsu, and Yukihiro Goda
Subjects: Molar, chemistry.chemical_compound, Chromatography, chemistry, Quantitative nmr, Perillaldehyde, Sensitivity (control systems), Perilla
Published: 2019
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20. P737Sympathetic-parasympathetic imbalance by Holter analysis following carotid endarterectomy may be associated with a potential cause of myocardial infarction

Author: Y Ikari, F Kunugita, K Ogasawara, Y Morino, Koichiro Yoshioka, Masataka Nakano, T Komatsu, Norihiko Shinozaki, Mari Amino, and R Yoshizawa
Subjects: medicine.medical_specialty, business.industry, medicine.medical_treatment, Internal medicine, medicine, Cardiology, Carotid endarterectomy, Myocardial infarction, Cardiology and Cardiovascular Medicine, business, medicine.disease
Published: 2018
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21. BIOLOGICAL SIGNIFICANCE OF ACUTE RESPONSES OF ARTERIAL STIFFNESS MONITORED WITH CARDIO-ANKLE VASCULAR INDEX (CAVI) TO THE VARIOUS VASCULAR LOADINGS IN RABBIT MODEL

Author: Megumi Aimoto, Kiyoshi Sakuma, Kazuhiro Shimizu, T. Komatsu, Kohji Shirai, Mao Takahashi, K. Watanabe, Yoshinobu Nagasawa, Shun Takagi, Akira Takahara, Tatsuo Chiba, and H. Shiratori
Subjects: medicine.medical_specialty, Physiology, business.industry, medicine.disease, Biological significance, Internal medicine, Internal Medicine, Arterial stiffness, medicine, Rabbit model, Cardiology, Cardio-ankle vascular index, Cardiology and Cardiovascular Medicine, business
Published: 2019
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22. Social innovation business models: Coping with antagonistic objectives and assets

Author: Sharam Alijani, Alessandro Deserti, Manuela Celi, Francesca Rizzo, T. T. Komatsu, Sharam Alijani , Catherine Karyotis, Komatsu, T., Deserti, A., Rizzo, F., Celi, M., and Alijani, S.
Subjects: Knowledge management, Process management, Bricolage, Management and Accounting, Business transformation, Business relationship management, 0502 economics and business, 050602 political science & public administration, Multisided business model, Business, Business case, hybridity, service design, Multisided business models, business.industry, Business rule, Artifact-centric business process model, Hybridity, Social innovation, Business, Management and Accounting, 05 social sciences, Business process modeling, 0506 political science, New business development, Business analysis, business, 050203 business & management
Abstract: Purpose The chapter provides empirical research results on the peculiarities of social innovation and the specific features that its business model must support. It concludes by proposing a Social Innovation Business Model Canvas and steps towards Social Innovation typologies. Methodology/approach The research is based on the results of a comparative analysis of 25 business case studies and 32 biographies conducted within the SIMPACT research framework. We then implemented a process of reverse engineering to uncover the business models behind the cases which facilitated the creation of a typology for different social innovation business models. Reverse engineering is the application of tools and processes used to study new business ventures in comparison with existing ones. As such, it sheds further light on the broad characteristics of social business models and their value creation mechanisms. The evidence coming from the cases were analyzed within a new business model and clustered to identify a typology of business models of social innovations. Findings The main SIMPACT findings, resulting from the reverse engineering process and upon which our discussion is based, can be seen in the following distinguishing characteristics of SI business models. SI business models are: configured around finding complementarity between antagonistic assets and seemingly conflicting logics; often structured around a divergence in the allocation of cost, use, and benefit leading to multiple value propositions; modeled on multiactor/multisided business strategies, and developed as frugal solutions and through actions of bricolage. Four typologies of social innovation were identified: beneficiary as actor, beneficiary as customer, beneficiary as user, and community-asset-based models. Research implications While much attention has been placed on for-profit business models, there is little literature on social/not-for-profit business models. This chapter can add to this gap by providing substantial empirical evidence. Practical implications Practitioners in the field of social innovation, particularly the growing intermediary sector, could integrate the findings of the research in their work. Social implications The work is also leading to the construction of a future business toolbox for social innovation, which will be even more useful for incubators, accelerators, and supporting structures. Originality/value Research presented in this chapter is the result of an extensive comparative analysis across all of Europe, including examples of failure, and the first to propose a typology of SI Business Models.
Published: 2017

23. 136 Non-invasive evaluation of pachydermia of pachydermoperiostosis by vital confocal microscopy

Author: T. Komatsu, T. Nomura, and K. Kabashima
Subjects: Pathology, medicine.medical_specialty, biology, business.industry, Non invasive, Cell Biology, Dermatology, biology.organism_classification, Biochemistry, law.invention, Pachydermia, Confocal microscopy, law, Medicine, business, Molecular Biology
Published: 2019
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24. (136) Dual Targeted Theranostic Nanomedicines for Local and Systemic Non-Opioid Analgesia in Trauma

Author: Shannon Loftus, Jelena M. Janjic, Fatih Zor, T. Komatsu, V. Gorantla, Michele Herneisey, Eric Lambert, and Lu Liu
Subjects: Drug, Theranostic Nanomedicine, business.industry, media_common.quotation_subject, Chronic pain, Nerve injury, medicine.disease, Bioinformatics, Anesthesiology and Pain Medicine, Neurology, Opioid, Drug delivery, Neuropathic pain, medicine, Systemic administration, Neurology (clinical), medicine.symptom, business, medicine.drug, media_common
Abstract: Acute neuropathic pain (ANP) resulting from civilian and combat traumatic injuries has dramatic impact on society at large as it poses with significant personal and economic burden. With opioid abuse epidemic currently in public eye across all levels of society, it is pertinent new therapeutic modalities are needed to effectively treat and resolve ANP. Neuroinflammation is recognized as one of the primary drivers of acute neuropathic to chronic pain transition leading to prolonged disability and loss of productivity. We hypothesize that the lack of molecular and cellular targeting specificity to effectively engage key cellular players in the neuronal injury milieu leads to non-opioid and local analgesia pain control failures in some patients. Here we present novel nanomedicine strategies for targeted non-opioid drug delivery directly to the key cells at the site of injury, immune cells and nerves. Since drug delivery is cell targeted, smaller drug doses are expected to produce similar or improved therapeutic effects over non-targeted therapies. Further we achieve overall dramatically decreased systemic exposure (up to 1000 fold), which can diminish unwanted side effects. Presented nanomedicine formulations provide sustained drug release leading to dosing frequency decrease and extended duration of therapeutic effects (up to 30 days or longer). As designed, these pain directed nanomedicines could improve patient response to treatment while minimizing systemic exposure/overdose risk, tolerance and/or dependency. To the best of our knowledge this is the first example of dual administration (systemic and local) nanomedicine design for acute post-trauma pain applicable to both civilian and military settings. We present fabrication and optimization of immune cell and nerve targeted nanoformulations. Evaluation for controlled release kinetics and safety of the these systems with optimized drug payloads in vivo in rat models of nerve injury and mouse inflammatory pain models following local and systemic administration is also presented.
Published: 2019
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25. A Survey of Very Large Capacity On-Line File Systems Using Optical Disks.

Author: Y. Kinouchi, H. Yamaguchi, T. Komatsu, and N. Sakurai
Published: 1987

26. Impact of Blood Pressure Control on Thromboembolism and Major Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J‐RHYTHM Registry

Author: Eitaro Kodani, Hirotsugu Atarashi, Hiroshi Inoue, Ken Okumura, Takeshi Yamashita, Toshiaki Otsuka, Hirofumi Tomita, Hideki Origasa, M. Sakurai, Y. Kawamura, I. Kubota, Y. Kaneko, K. Matsumoto, S. Ogawa, Y. Aizawa, I. Kodama, E. Watanabe, Y. Koretsune, Y. Okuyama, A. Shimizu, O. Igawa, S. Bando, M. Fukatani, T. Saikawa, A. Chishaki, N. Kato, K. Kanda, J. Kato, H. Obata, M. Aoki, H. Honda, Y. Konta, T. Hatayama, Y. Abe, K. Terata, T. Yagi, A. Ishida, T. Komatsu, H. Tachibana, H. Suzuki, Y. Kamiyama, T. Watanabe, M. Oguma, M. Itoh, O. Hirono, Y. Tsunoda, K. Ikeda, T. Kanaya, K. Sakurai, H. Sukekawa, S. Nakada, T. Itoh, S. Tange, M. Manita, M. Ohta, H. Eguma, R. Kato, Y. Endo, T. Ogino, M. Yamazaki, H. Kanki, M. Uchida, S. Miyanaga, K. Shibayama, N. Toratani, T. Kojima, M. Ichikawa, M. Saito, Y. Umeda, T. Sawanobori, H. Sohara, S. Okubo, T. Okubo, T. Tokunaga, O. Kuboyama, H. Ito, Y. Kitahara, K. Sagara, T. Satoh, K. Sugi, Y. Kobayashi, Y. Higashi, T. Katoh, Y. Hirayama, N. Matsumoto, M. Takano, T. Ikeda, S. Yusu, S. Niwano, Y. Nakazato, Y. Kawano, M. Sumiyoshi, N. Hagiwara, K. Murasaki, H. Mitamura, S. Nakagawa, K. Okishige, K. Azegami, H. Aoyagi, K. Sugiyama, M. Nishizaki, N. Yamawake, I. Watanabe, K. Ohkubo, H. Sakurada, S. Fukamizu, M. Suzuki, W. Nagahori, T. Nakamura, Y. Murakawa, N. Hayami, K. Yoshioka, M. Amino, K. Hirao, A. Yagishita, K. Ajiki, K. Fujiu, Y. Imai, A. Yamashina, T. Ishiyama, M. Sakabe, K. Nishida, H. Asanoi, H. Ueno, J. D. Lee, Y. Mitsuke, H. Furushima, K. Ebe, M. Tagawa, M. Sato, M. Morikawa, K. Yamashiro, K. Takami, T. Ozawa, M. Watarai, M. Yamauchi, H. Kamiya, H. Hirayama, Y. Yoshida, T. Murohara, Y. Inden, H. Osanai, N. Ohte, T. Goto, I. Morishima, T. Yamamoto, E. Fujii, M. Senga, H. Hayashi, T. Urushida, Y. Takada, N. Tsuboi, T. Noda, T. Hirose, T. Onodera, S. Kageyama, T. Osaka, T. Tomita, K. Shimada, M. Nomura, H. Izawa, A. Sugiura, T. Arakawa, K. Kimura, T. Mine, T. Makita, H. Mizuno, A. Kobori, T. Haruna, M. Takagi, N. Tanaka, H. Shimizu, T. Kurita, K. Motoki, N. Takeda, Y. Kijima, M. Ito, A. Nakata, Y. Ueda, A. Hirata, S. Kamakura, K. Satomi, Y. Yamada, Y. Yoshiga, H. Ogawa, M. Kimura, T. Hayano, T. Kinbara, H. Tatsuno, M. Harada, K. F. Kusano, M. Adachi, A. Yano, M. Sawaguchi, J. Yamasaki, T. Matsuura, Y. Tanaka, H. Moritani, T. Maki, S. Okada, M. Takechi, T. Hamada, A. Nishikado, Y. Takagi, I. Matsumoto, T. Soeki, Y. Doi, M. Okawa, H. Seo, S. Kitamura, K. Yamamoto, M. Akizawa, N. Kaname, S. Ando, S. Narita, T. Inou, Y. Fukuizumi, K. Saku, M. Ogawa, Y. Urabe, M. Ikeuchi, S. Harada, H. Yamabe, Y. Imamura, Y. Yamanouchi, K. Sadamatsu, K. Yoshida, T. Kubota, N. Takahashi, N. Makino, Y. Higuchi, T. Ooie, T. Iwao, K. Kitamura, T. Imamura, K. Maemura, N. Komiya, M. Hayano, H. Yoshida, and K. Kumagai
Subjects: Male, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, hypertension, medicine.drug_class, Diastole, Hemorrhage, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Japan, Risk Factors, Internal medicine, Odds Ratio, Medicine, Humans, Arrhythmia and Electrophysiology, atrial fibrillation, 030212 general & internal medicine, Prospective Studies, Registries, Risk factor, Antihypertensive drug, anticoagulation, Antihypertensive Agents, Original Research, Ischemic Stroke, Intracranial Hemorrhage, Aged, Proportional Hazards Models, business.industry, Hazard ratio, Warfarin, blood pressure, Atrial fibrillation, Odds ratio, Middle Aged, thromboembolism, medicine.disease, Blood pressure, High Blood Pressure, lcsh:RC666-701, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract: Background To clarify the influence of hypertension and blood pressure ( BP ) control on thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation, a post hoc analysis of the J‐ RHYTHM Registry was performed. Methods and Results A consecutive series of outpatients with atrial fibrillation was enrolled from 158 institutions. Of 7937 patients, 7406 with nonvalvular atrial fibrillation (70.8% men, 69.8±10.0 years) were followed for 2 years or until an event occurred. Hypertension was defined as a systolic BP ≥140 mm Hg, a diastolic BP ≥90 mm Hg, a history of hypertension, and/or antihypertensive drug use. Hypertension was an independent risk factor for major hemorrhage (hazard ratio 1.52, 95% CI 1.05–2.21, P =0.027) but not for thromboembolism (hazard ratio 1.05, 95% CI 0.73–1.52, P =0.787). When patients were divided into quartiles according to their systolic BP at the time closest to the event or at the end of follow‐up (Q1, CI 1.75–4.74, P CI 1.02–2.53, P =0.041) after adjustment for components of CHA 2 DS 2 ‐ VAS c score, warfarin use, and antiplatelet use. A systolic BP of ≥136 mm Hg was an independent risk factor for thromboembolism and major hemorrhage. Conclusions BP control appears to be more important than a history of hypertension and baseline BP values at preventing thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation. Clinical Trial Registration URL : http://www.umin.ac.jp/ctr . Unique identifier: UMIN 000001569.
Published: 2016

27. A case based discussion on the role of Design Competences in Social Innovation

Author: Manuela Celi, Francesca Rizzo, Alessandro Deserti, T. T. Komatsu, Peter Lloyd and Erik Bohemia, Komatsu, T., Celi, M., Rizzo, F., and Deserti, A
Subjects: Knowledge management, business.industry, design thinking, Social Innovation, Design Thinking, Design Competence, design competences, Social innovation, SI Economic and Social Value, Business, social innovation, design thinking, design competences, SI economic and social value
Abstract: Thus far, many contributions in the field of design have described design’s role in the life cycle of a successful Social Innovation (SI). Design, in fact, has been proposed by many authors to be the most suitable approach to developing SI initiatives from their start-up to release. In particular, some authors have proposed Design Thinking as the best methodology for the development of new SIs; while others, promote Participatory Design as the best method to support SIs, heralding its process of collaboration, networking and coproduction. Nevertheless, many research results have demonstrated that the need to find a balance between social and economic objectives is one of the main barriers to SI. This paper discusses these general results as they have been elaborated in the context of the SIMPACT European project and focuses on the value of design competences to better design SI products, services and brands, which is explored through the discussion of two well established cases of SI in Europe.
Published: 2016

28. Effect of E. coli vaccination during the dry period on the immune function of Holstein cows

Author: J. Yasuda, Y. Niwa, M. Sato, M. Aoki, T. Komatsu, K. Okada, and S. Sato
Subjects: Vaccination, Animal science, Immune system, Period (gene), Biology
Published: 2012
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29. (157) Design and development of novel nanotherapeutics with 30 day long anti-inflammatory and analgesic action

Author: Jelena M. Janjic, Lu Liu, and T. Komatsu
Subjects: Anesthesiology and Pain Medicine, Neurology, Action (philosophy), business.industry, medicine.drug_class, Analgesic, Medicine, Neurology (clinical), Pharmacology, business, Anti-inflammatory
Published: 2017
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30. CO2-Einsatz bei jedem Patienten?

Author: M Bretthauer, M Kalager, K Kandiah, Axel Eickhoff, Karl-Hermann Fuchs, A Schmidt, R M Yunus, K Murakami, H Minami, B Memon, Hans-Olov Adami, T. Suzuki, K Caca, T Komatsu, H Kataoka, S Subramaniam, Jürgen Hochberger, Ulrike Beilenhoff, M A Memon, J Hayano, Pradeep Bhandari, Edris Wedi, Ulrike W. Denzer, L Altenhofen, and M Enderle
Subjects: 03 medical and health sciences, 0302 clinical medicine, 030211 gastroenterology & hepatology, 030212 general & internal medicine
Published: 2017
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31. Effects of feeding colostrum from E.coli vaccinated dams on protection against Cryptosporidium parvum and lymphocyte subset population in neonatal calves

Author: T. Itagaki, Y. Niwa, K. Okada, T. Komatsu, M. Aoki, and J. Yasuda
Subjects: education.field_of_study, Cryptosporidium parvum, biology, Population, Colostrum, biology.organism_classification, education, Virology, Lymphocyte subsets
Published: 2011
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32. Nutrition Education Reduce Daily Variation of Rectal Volume and Dose in Patients with Prostate Cancer Treated with Intensity-Modulated Radiation Therapy

Author: T. Komatsu, K.I. Sakata, H. Fujita, K. Aizawa, Masaru Takagi, H. Ikeda, Y. Yaegashi, Masanori Someya, Y. Takada, T. Kobayashi, Y. Kitsu, and K. Ukon
Subjects: 0301 basic medicine, Cancer Research, medicine.medical_specialty, 030109 nutrition & dietetics, Radiation, business.industry, Nutrition Education, Urology, Intensity-modulated radiation therapy, medicine.disease, 03 medical and health sciences, Prostate cancer, Oncology, Volume (thermodynamics), medicine, Radiology, Nuclear Medicine and imaging, In patient, business
Published: 2018
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33. The impact of continuing ALK inhibitors beyond initial disease progression on clinical outcome in patients with advanced ALK-positive non-small cell lung cancer: Results of a multicenter retrospective analysis

Author: H. Okabayashi, Koichi Saruwatari, Sho Saeki, K. Ichikado, K. Kawamura, T. Komatsu, Megumi Inaba, R. Fujita, Kosuke Imamura, Y. Sakata, Shinji Fujii, K. Iyonaga, Kosuke Kashiwabara, Takuro Sakagami, Yusuke Tomita, T. Kumabe, S. Ushijima, O. Sakamoto, and Shinya Sakata
Subjects: Oncology, medicine.medical_specialty, business.industry, Disease progression, ALK-Positive, Hematology, medicine.disease, Internal medicine, Retrospective analysis, medicine, In patient, Non small cell, Lung cancer, business
Published: 2018
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34. Prolonged carbon dioxide insufflation under general anesthesia for endoscopic submucosal dissection

Author: K. Serada, A. Sakamoto, Haruhiro Inoue, T. Suzuki, H. Minami, Y. Sato, R. Masusda, Y. Kobayashi, and T. Komatsu
Subjects: Male, Insufflation, Vital capacity, medicine.medical_specialty, Time Factors, Partial Pressure, Endoscopic mucosal resection, Anesthesia, General, Air embolism, Statistics, Nonparametric, Forced Expiratory Volume, Gastroscopy, medicine, Humans, Prospective Studies, Intestinal Mucosa, Duodenoscopy, Carbon dioxide insufflation, Aged, Aged, 80 and over, medicine.diagnostic_test, business.industry, Dissection, Gastroenterology, Endoscopic submucosal dissection, Carbon Dioxide, Middle Aged, medicine.disease, Surgery, Endoscopy, Gastric Mucosa, Anesthesia, Arterial blood, Female, Esophagoscopy, business
Abstract: BACKGROUND AND STUDY AIMS: Carbon dioxide (CO 2 ) insufflation for endoscopy has been reported to provide superior recovery and is expected to reduce the risk of serious complications, including air embolism and tension pneumothorax, whereas general anesthesia offers some advantages not found under intravenous sedation. Little is known about the effect of prolonged CO 2 insufflation into gastrointestinal tracts on arterial CO 2 tension (PaCO 2 ). Here we introduce the use of general anesthesia with CO 2 insufflation for esophagogastroduodenal endoscopic submucosal dissection (ESD). PATIENTS AND METHODS: A prospective observational study was conducted in a university-affiliated hospital. A total of 100 patients were scheduled for esophagogastroduodenal ESD under general anesthesia with CO 2 insufflation, using standardized anesthesia techniques and unchanged ventilatory settings. Arterial blood gas analyses were repeated at predetermined time intervals. RESULTS: Of the initial 100 participants, 94 patients undergoing ESD and four patients undergoing endoscopic mucosal resection completed the study. The median procedure time was 122 minutes (range 29 – 309 minutes). The median baseline PaCO 2 of 28 mmHg increased to a median peak PaCO 2 of 39 mmHg ( P < 0.001), with marked inter-individual variability in the time courses of changes in PaCO 2 . The correlation coefficient of PaCO 2 with the procedure time was low (r = 0.194; n = 577, P < 0.0001). FEV 1.0 % (forced expiratory volume in 1 second/forced vital capacity) of < 70 % and esophagoscopy vs. gastroduodenoscopy were relative enhancement factors of PaCO 2 . CONCLUSION: Increases of PaCO 2 during esophagogastroduodenal ESD under general anesthesia with CO 2 insufflation remained within acceptable or readily controllable ranges, and are little enhanced by prolongation of the procedure. Esophagogastroduodenal ESD can be performed safely and feasibly with this procedure.
Published: 2010
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35. Tumor immunity and immunosurveillance (PP-093)

Author: G. Bi, K. Hanada, M. Maeda, W. J. Norde, A. Piwko-Czuchra, M. Hojjat-Farsangi, C. Tsai, G. Ball, C. Sarkar, Alireza Razavi, U. Yamashita, A. Jamali, O. Gavriliuc, S. Darzi, W. Wang, V. Subr, Y. Endo, M. Mehrabi Bahar, M. Hung, M. W. L. Teng, M. Miiluniemi, R. Sen, S. Bae, H. C. Hung, A. Anjomshoaa, L. Cazin, D. Zhao, I. J. Shubina, R. Maekawa, M. Shin-ya, M. Pfreundschuh, S. M. ElZoghaby, T. A. Luger, A. Nabi, N. Minato, Y. Kao, M. S. Alam, R. Spisek, M. Maki, V. Huovinen, T. Murata, R. Anderson, E. Nicholson, M. van Egmond, J. Tomala, C. Wang, W. Sun, M. Momeny, S. Lee, M. L. Mora-García, N. Alizadeh, D. Jin, I. Comerford, E. P. Kisseleva, R. M. Talaat, S. Kim, D. Wakita, J. Strid, M. Shimomura, S. Wang, Y. Tamura, Y. Tanaka, J. Ichikawa, M. Inaba, H. Lee, R. Nohra, P. Hu, J. Sun, N. Okazaki, K. Franciszkiewicz, G. M. Fadaly, M. Maksimow, A. Rosca, W. L. Olszewski, T. Inozume, Y. Zhang, S. F. Ngiow, H. K. Takahashi, M. H. Huang, S. Hashino, H. Li, K. S. Titov, H. C. Toh, H. Lim, T. Yaguchi, M. Bögels, B. Kubuschok, M. Wang, G. Nunez, A. Pourazar, F. Mami-Chouaib, P. Rossmann, K. Moriya, A. Eric, N. Li, S. Ichimiya, R. Kumar, H. Mao, L. H. El Sayed, T. Chen, I. Kuiatse, Y. M. Tzeng, A. V. Schattenberg, G. Kristiansen, Y. Mizote, P. Lei, Y. Harata-Lee, H. Ihn, M. R. Khorramizadeh, M. R. Egeler, B. Sumer, H. Kim, S. Gnjatic, C. K. Lee, R. Kiessling, Y. Tomita, Y. Ji, E. A. Starickova, J. Kopecny, E. Nakazawa, M. W. Teng, D. J. DiLillo, M. E. Castro-Manrreza, S. N. M. AbouRawach, J. C. Wallace, Mahmood Jeddi-Tehrani, H. I. Huang, T. Sakurai, F. Golsaz Shirazi, M. Schaap, Y. Nishimura, N. M. AbouRawach, W. Yang, A. Zamani, S. Hong, A. Wakabayashi, K. Berg Lorvik, W. Shi, E. Nakayama, V. Raina, D. Jung, D. J. Cole, A. Hosoi, B. Becher, L. Keyue, T. Torigoe, J. Hasheminia, H. Matsuda, Y. Adachi, V. Bronte, E. Kato, M. H. Andersen, B. Weiss-Steider, K. Sumida, A. Gruia, M. Voskort, M. Mandai, H. Baba, A. Korman, Z. Qin, M. Khorramizadeh, B. Rihova, G. E. Lyons, H. Yoon, T. Tang, C. A. Hansen, M. Nakatsugawa, Y. Kim, C. Soderberg Naucler, M. Harada, P. Kralikova, M. Hajzadeh, M. Hoseinipanah, A. Uenaka, S. Inoda, C. Gest, N. Shibagaki, M. Quigley, O. S. Naga, J. Chen, H. Liu, T. Ito, M. Saberi-Firoozi, J. Khoshnoodi, F. Zhu, H. M. Ghoneim, R. Esmaeili, Z. Jahanshiri, J. Lee, Y. Hirohashi, N. Hosaka, A. Berahmeh, M. Bodogai, I. Markovic, N. Fu, M. Hong, Y. Kanthaiah, J. D. Holland, J. King, H. S. Kang, X. Huang, M. Brenner, S. Anghel, S. Nagoya, J. Soria, I. Konishi, M. Kato, J. Shin, N. Sato, R. Beelen, G. K. Brown, Y. J. Zhuang, K. Ulbrich, S. Senju, T. Kishida, J. Fucikova, J. Kim, Iwona Hus, F. Xu, M. Inoue, M. Shabani, Lorenzo Mortara, L. Zheng, S. Ghaffari, N. Ozoren, K. Nakatsuka, E. Gélizé, M. Zhang, R. Korenstein, W. Li, P. Marrack, A. Feng, B. Toh, N. Matsumura, R. A. Kemp, J. Hernández-Montes, S. Werner, C. M. Diaz-Montero, H. Hayashi, X. Zha, T. F. Tedder, Y. Wu, E. Torkabadi, A. Choudhury, M. Asaka, Y. Bi, C. C. Johansson, K. Kakimi, Y. G. Mansurova, K. Oida, Y. Kusumoto, M. J. Smyth, C. J. Chen, H. L. Dong, Jamshid Hadjati, I. Besu-Zizak, T. Takeuchi, O. Buyanovskaya, A. V. Krylov, I. Juko-Pecirep, M. A. Firer, A. Girardin, M. Fukuda, K. T. Y. H. Hiroshi Shiku, I. Mahmud, S. Jalkanen, S. H. Tu, N. K. Akhmatova, M. Hajimoradi, K. Udaka, X. Zhang, S. Beissert, Y. Urade, K. Ghaffarzadehgan, J. Strohalm, Z. Han, C. Akekawatchai, X. Cao, M. V. Kiselevsky, Y. Keisari, T. Tan, T. Yoshikawa, S. Muto, D. Mougiakakos, H. Dolabi, Q. Wang, H. Nakano, S. R. Hadrup, V. Frangione, Roberto S. Accolla, Y. Hwang, H. Mochimaru, R. Okita, K. Ohmori, H. Sima, J. Prieto, S. A. Rosenberg, I. Poschke, M. I. Nishimura, J. Medina, P. Wen, Y. Lu, R. Hadavi, A. Corthay, Y. Kawakami, S. Bao-en, M. Yousefi, M. S. Hassan, M. Torabi Rahvar, S. Mohanty, P. Nagarkatti, E. A. Lebedinskaya, Y. Li, V. Paunescu, Y. Zheng, E. Hafez, Y. H. Lee, W. Song, K. Soliman, W. Gao, M. Matsui, Z. Juranic, K. Hebeda, R. Gress, T. Kishimoto, C. Zhang, Q. Xie, C. A. Rosenstadt, K. Klimesova, J. Zhou, S. Kawaguchi, B. Clausen, J. Jiang, Magdalena Wasiak, N. Sakemura, J. L. Teillaud, H. M. Koheil, M. Ahmad, N. Ding, M. Jevric, I. V. Lyamina, Z. Zakostelska, M. Soengas, T. Takaki, H. Dai, D. Mehrabani, K. Aritake, D. Chen, J. Kato, M. Djordjevic, S. Fukushima, I. M. Svane, A. Rahbar, T. Nishimura, B. Kharma, M. W. Schilham, I. Entin, B. von Scheidt, T. Taguchi, Y. Nakashima, D. Preuss, K. Mimura, A. Tominaga, T. Fujita, K. Kido, H. Raziee, S. Ikehara, T. Komatsu, H. Yagura, Y. Yoshida, G. Capone, X. Wang, R. Varin, N. Kumagai, M. Kochetkova, A. Hayday, M. Karikoski, Chun-Yen Chang, H. Maeng, S. Sugawara, S. Ghadri, H. Chmelova, A. Sun, W. Pei'e, L. A. Sherman, A. Puaux, A. Amari, E. Saller, W. H. Fridman, N. Junker, M. Sarafraz yazdi, K. Wejksza, M. Kovar, H. Yang, C. Hu, Y. Arima, A. Le Floc'h, Y. Nakamura, R. Morita, Y. Iwakura, H. Oster, M. Zabala, I. Z. Matic, V. Chew, A. Memarian, G. Jiang, B. Huang, I. Hammami, T. N. M. Schumacher, P. Vossough, N. Tsukamoto, V. I. Lioudyno, M. Sirova, M. Oka, J. Eyles, H. Madadi, H. Stauss, A. Itai, L. U'Ren, B. Tsai, H. W. Chen, X. Qu, R. García-Rocha, Y. Goto, H. Ozaki, Patrizia Castellani, Q. Shao, K. Wang, A. Talei, E. Ivansson, C. L. Wang, J. J. Montesinos-Montesinos, H. Dolstra, D. Nistor, M. Li, S. Hirata, T. Etrych, X. M. Gao, L. Li, O. Mazda, D. Andrews, B. Ansaripour, P. Yotnda, Q. J. Wang, T. Tsukahara, J. Bartunkova, H. Lei, H. Fredrix, A. De Lerma Barbaro, G. R. Fajardo-Orduña, Paulina Wdowiak, L. Gunn, W. Zuo, Q. Zhang, T. Sparwasser, S. Chen, Y. Yang, L. Liu, Y. Kikuchi, T. Aji, S. Nakai, K. H. Lim, M. M. Andalib, H. Norell, U. V. Ozkurede, T. Shimada, A. Andalib, J. Slansky, Xiao-Tong Yuan, P. Chong, Y. Miura, J. Inoue, T. Yamashita, Y. Faghani, S. Hosseini, H. Hosseinnezhad, K. Dan, Q. Liu, C. Park, A. Prevost-Blondel, A. Tomar, H. Pfister, S. Okano, H. Harimoto, H. J. Baelde, S. Shimada, J. Vom Berg, B. Deng, J. C. Becker, S. Samarghandian, A. K. Chávez-Rueda, J. C. Yang, A H Zarnani, T. Nakatsura, N. Erfani, R. van der Voort, R. C. Rees, X. Wen, V. Gutierrez-Serrano, H. Kishimoto, A. Ghaderi, H. Ren, Y. Zhong, A. Lankester, A. Amini, S. A. Williams, G. Jin, M. Mittelman, P. Thor Straten, I. Ng, T. Suzuki, C. Tovar, N. Harashima, Y. Oshima, I. V. Oradovskaya, M. Mahmoudian, I. C. Le Poole, Y. Furukawa, V. Budinsky, Y. Liu, M. Hori, Nazanin Mojtabavi, H. Rabbani, S. A. Shamsdin, Z. Tayarani, H. Fan, Y. Hayashida, K. Iwamura, B. Bogen, S. Vivekanandhan, V. Phillips, L. Berge-Hansen, Q. Yin, N. Lee, Y. Sasaki, Q. Li, M. Nishibori, K. Sato, N. D. Spivey, G. Y. Liu, H. Asanuma, H. Kang, R. Ophir, H. Mellstedt, D. Crisnic, A. Irie, J. Klarquist, B. Seliger, H. Wake, N. McLaughlin, S. Park, D. Vetvicka, J. T. Baran, I. Gustavsson, N. Arandi, Y. Sher, J. Kong, T. Ando, L. Volkova, J. Yan, H. Fang, N. Matumura, M. Arjipour, D. Handke, M. Ghasemi, A. E. Reeve, P. Berraondo, O. Hovorka, P. Chow, R. A. Sharifian, G. Shen, G. Hu, S. J. Liu, R. Abès, H. Takahashi, Anna Dmoszynska, C. A. Don-López, N. Tajik, H. Hwang, N. Gül, K. Horie, N. Rahbar-Roshandel, F. M. Bojin, D. Li, J. Hamanishi, H. Heslop, Jacek Roliński, M. Shimizu, J. Wang, T. Hirano, H. Sumimoto, R. B. Sørensen, G. M. Woods, N. Borojevic, S. Stevanovic, M. K. Zaman, Z. Fu, E. Morris, A. Al-Khami, M. Kverka, W. Shi-jie, A. Yano, M. Gewartowska, H. Okuyama, S. Kale, J. P. Vannier, F. Ciuculescu, K. Loser, Z. Zhang, U. Joimel, F. M. Maas, C. Lemetre, A. H. M. Taminiau, J. Tavakkol Afshari, M. Sang, M. Cristea, D. Tobi, M. Motamedi, X. Zhao, Y. Hisa, J. P. Abastado, S. I. Lin, L. Cao, Y. Yoshioka, M. Isobe, M. Murakami, H. Hisha, V. Younesi, N. Krug, M. Ahmadzadeh, E. Saka, Z. Zhan, C. Bunu, A. Monroy-García, S. Wu, Y. Ohue, B. Matharoo-Ball, A. Emami, R. Bos, F. Shokri, W. Xing, T. Suda, O. V. Lebedinskaya, J. Ishizaki, T. Ramadan, G. Brown, S. Mori, A. Rezaei, H. Haro, R. Xia, T. Tsunoda, Y. Narita, Y. Jin, A. Biragyn, H. Irjala, P. C. W. Hogendoorn, J. Betka, C. Kudo-Saito, S. Xiaobai, Y. Sung, M. Moscicka-Wesolowska, T. Baba, A. Saad, W. Lee, A. A. Pourfathollah, G. R. Hill, A. Davari sadat, M. Hattori, J. Nisanov, S. Santos, L. Chen, P. Vosough, J. Zhang, T. Martins da Palma, T. M. de Witte, Z. M. Hassan, A. Kreiss, Y. Saitou, L. Zhang, S. R. McColl, T. Hudcovic, J. Yeh, M. Oft, L. Jianing, L. Han, K. Kitaoka, O. Moaven, X. Liu, X. Ren, C. A. Taher, H. Kitamura, A. Tanaka, Y. Ikuta, N. Ardaiz, S. Arab, J. Fioravanti, Agnieszka Bojarska-Junak, S. Rezaie, H. Tlaskalova Hogenova, A. Takahashi, C. Soria, W. Zibing, T. Wan, J. Kang, U. Gyllensten, A. Swanson, L. Ong, X. Jiang, M. M. Amiri, M. Ahmadi, S. Fan, C. A. Tatu, D. Berghuis, T. Abdolahi, J. Guosheng, A. Nardin, H. Asgarian-Omran, B. Vafadar-Isfahani, M. Salmi, S. Smola, R. Saeedi, R. Imamura, M. Jolicoeur, S. Liu, L. Yang, P. Wang, L. L. Pritchard, Z. Li, B. Damdinsuren, X. Lu, M. Lee, T. Nakagawa, J. Liu, B. Chiang, G. Tanasie, M. Kano, S. Ngiow, M. Nooridaloii, M. Antsiferova, K. Harada, S. Eikawa, M. Eisenring, F. Neumann, J. R. Wunderlich, K. Yoshimoto, K. Abiko, T. Otsuki, M. Jafarzadeh, Y. F. Liao, E. Blot, Y. Nagai, G. De Crescenzo, M. Yekaninejad, Y. Noguchi, M. Nagarkatti, P. B. Olkhanud, M. Inic, C. Prakash, C. Tatu, S. Ono, A. Lindbloom, F. Marttila-Ichihara, R. Abe, T. Okamoto, and K. Yanaba
Subjects: Immunosurveillance, business.industry, Immunology, Cancer research, Immunology and Allergy, Medicine, General Medicine, Tumor immunity, business
Published: 2010
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36. Abstract P4-03-12: Effects of PI3K inhibitors on endocrine-resistant cell lines and differences in the characteristics of ER positive breast cancer cells after acquired resistance to the inhibitors

Author: Masafumi Iida, Shunta Sasaki, Misato Nakamura, T Komatsu, M Saito, S-I Hayashi, Kouki Tsuboi, Emi Tokuda, and Toshifumi Niwa
Subjects: Cancer Research, Everolimus, medicine.drug_class, Buparlisib, Cancer, Estrogen receptor, Biology, medicine.disease, chemistry.chemical_compound, Breast cancer, Oncology, chemistry, Cell culture, Estrogen, medicine, Cancer research, PI3K/AKT/mTOR pathway, medicine.drug
Abstract: Background Mutations in phosphatidylinositol 3-kinase (PI3K), which encodes the catalytic subunit of PI3Kα, is one of the most frequent genomic alterations and is found in about 40% of estrogen receptor (ER)-positive, HER2 negative breast cancers. PIK3CA mutations promote the growth and proliferation of cancers via activation of the PI3K/mammalian target of rapamycin pathway and can mediate resistance to endocrine therapies in breast cancer. Although several clinical trials for PI3K inhibitors (PI3Kis) in ER-positive metastatic breast cancers are ongoing, the effects of PI3Kis on endocrine-resistant breast cancers with various characteristics and definitive biomarkers of PI3Kis are unclear. Using endocrine-resistant cells established in our laboratory, we evaluated the efficacy of PI3Ki in these cell lines and identified the characteristics associated with acquired resistance to PI3Kis in endocrine-resistant cells. Results Long-term estrogen deprivation-resistant (EDR) cell lines and fulvestrant-resistant cell lines (MFR and TFR) were established from MCF-7 and T-47D cells in our previous studies. These cell lines showed different ER expression levels, including high expression (EDR-1), low expression (EDR-2, -3), or no expression (MFR, TFR); all of these cell lines had the same PIK3CA mutations as the parental cell lines. The pan-class1 PI3Ki buparlisib (BKM120) and α-specific PI3K inhibitor alpelisib (BYL719) inhibited the proliferation of endocrine-resistant cell lines when compared with their parental cells. Among endocrine-resistant cells, MFR cells were dramatically inhibited by PI3Kis. Colony formation assays indicated that MFR cells were more sensitive to PI3Kis than other cells lines. Next, we established PI3Ki- and everolimus-resistant cell lines from EDR-1, EDR-2, and MFR cells using BKM120, BYL719, and everolimus. Analysis of the time required to generate resistant cells showed that MFR cells required twice as long to acquire resistance compared with EDR cells. Furthermore, the time required to acquire resistance to BYL719 was shorter than that for BKM120. BYL719-resistant (BYL-R) cells were effectively inhibited by BKM120 to a degree similar to that of parental cells; however, BYL-R cells lost sensitivity to BYL719 and everolimus. Evelolimus-resistant (EVE-R) cells were also the same. In contrast, BKM120-resistant (BKM-R) cells showed less sensitivity to BKM120, BYL719, and everolimus. In other words, the pan-PI3Ki BKM120 was able to inhibit the growth of BYL-R and EVE-R cells, whereas BYL719 and everolimus were not able to inhibit BKM-R cells sufficiently. In addition, there were no changes in ER expression in EDR-1, EDR-2, and MFR cells exposed to PI3Kis for 1 h. Interestingly, ER expression on EDR-2 cells with acquired resistance to PI3Kis was increased compared with that in parental cells. Conclusion Our findings showed that PI3Kis exhibited remarkable efficacy in all types of EDR cells, particularly in fulvestrant-resistant cell lines. In PI3Ki- and everolimus-resistant cell lines, BKM120 and BYL719 showed different effects, and BYL719 and everolimus may exhibit cross-resistance. Furthermore, PI3Kis were likely to change the expression of ER. Citation Format: Tokuda E, Komatsu T, Sasaki S, Tsuboi K, Nakamura M, Iida M, Niwa T, Saito M, Hayashi S-I. Effects of PI3K inhibitors on endocrine-resistant cell lines and differences in the characteristics of ER positive breast cancer cells after acquired resistance to the inhibitors [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P4-03-12.
Published: 2018
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37. Interaction between diesel exhaust particles and cellular oxidative stress

Author: Yoshimasa Nihei, Ken Takeda, Kenichiro Suzuki, T. Komatsu, Masako Tabata, and Miyoko Kubo-Irie
Subjects: Diesel exhaust, Analytical chemistry, General Physics and Astronomy, Nanoparticle, Surfaces and Interfaces, General Chemistry, respiratory system, Mitochondrion, Condensed Matter Physics, medicine.disease_cause, complex mixtures, respiratory tract diseases, Surfaces, Coatings and Films, Secondary ion mass spectrometry, chemistry.chemical_compound, chemistry, Scanning transmission electron microscopy, medicine, Biophysics, Heme, Oxidative stress, Iron oxide nanoparticles
Abstract: The cellular oxidative stress by the exposure of diesel exhaust particles (DEPs) was investigated by using a time of flight secondary ion mass spectrometry (TOF-SIMS) and a real time reverse transcription polymerase chain reaction (RT-PCR) and a scanning transmission electron microscope (STEM). The DEP surfaces which had different properties were prepared for examining the oxidative stress by a gas chromatography mass spectrometry (GC–MS). We characterized the compositions in the different DEP surfaces and measured the gene expression of heme oxygenase-1 (HO-1) which were induced for preventing the cellular oxidative stress. From these results, it was clear that the DEP compositions (Fe, etc.) correlated closely with the cellular oxidative stress. From the results of a STEM analysis, we found out that the DEP were taken up in the cell and that some mitochondria in close association to the DEP showed damaged morphology. Moreover, the iron oxide nanoparticles of several nanometer were aggregated in the DEP. We therefore concluded that there was the interaction between the cellular functions and the particle properties.
Published: 2008
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38. A systematic method of countermeasure for environmental conservation to harmonize hydro-power development with natural environments

Author: T. Komatsu and Y. Yasuda
Subjects: Sustainable development, Engineering, business.industry, Environmental resource management, Endangered species, Natural (archaeology), Adaptive management, Countermeasure, Environmental protection, Earth Summit, Project management, business, Resilience (network), Environmental planning
Abstract: This paper presents a systematic method of countermeasure for environmental conservation to harmonize natural environments with hydro-power development based on two hydro-power construction in which Komatsu conducted directly as a project management in Japan. Since the 1990s, Sustainable Development was required in United Nation Conference on Environment and Development (the Earth Summit) as a commitment. In the construction of Okinawa pilot seawater pumped-storage power plant, and expanding construction for Okutadami and Otori hydro-power developments, project areas were located in biodiversity such as where precious endangered animals and birds have inhabited. Therefore, various countermeasures for environmental conservation in natural environments were proposed in order to harmonize construction of hydro-power development with natural environments. The proposed managements were systematically conducted by integrating the following measures:  Basic-countermeasure: design and countermeasure of preventive conservation for precious animals before the construction;  Countermeasure for hardware activities: field investigation for analyzing natural phenomenon, application of adaptive management in consideration of the conservation for precious animals, replanting in modified grounds based on natural resilience
Published: 2015
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39. Whole-genome prediction of fatty acid composition in meat of Japanese Black cattle

Author: Kenji Togashi, Hiroyoshi Iwata, K. Shimizu, A. Ogino, T. Komatsu, Kazuhito Kurogi, Akio Onogi, Takanori Yasumori, and N. Shoji
Subjects: Male, Genome, Meat, Genotype, Models, Genetic, Mean squared prediction error, Japanese Black cattle, Fatty Acids, General Medicine, Best linear unbiased prediction, Biology, Beef cattle, Breeding, Pedigree, Animal science, Phenotype, Quantitative Trait, Heritable, Genetics, Animals, Animal Science and Zoology, Cattle, Female, Fatty acid composition, Genomic selection
Abstract: Because fatty acid composition influences the flavor and texture of meat, controlling it is particularly important for cattle breeds such as the Japanese Black, characterized by high meat quality. We evaluated the predictive ability of single-step genomic best linear unbiased prediction (ssGBLUP) in fatty acid composition of Japanese Black cattle by assessing the composition of seven fatty acids in 3088 cattle, of which 952 had genome-wide marker genotypes. All sires of the genotyped animals were genotyped, but their dams were not. Cross-validation was conducted for the 952 animals. The prediction accuracy was higher with ssGBLUP than with best linear unbiased prediction (BLUP) for all traits, and in an empirical investigation, the gain in accuracy of using ssGBLUP over BLUP increased as the deviations in phenotypic values of the animals increased. In addition, the superior accuracy of ssGBLUP tended to be more evident in animals whose maternal grandsire was genotyped than in other animals, although the effect was small.
Published: 2015

40. Hydrophilic property of SiO2/TiO2 double layer films

Author: M. Nakamura, N. Kuzuya, T. Komatsu, M. Kobayashi, and T. Mochizuka
Subjects: Double layer (biology), business.industry, Chemistry, Metals and Alloys, Light irradiation, Surfaces and Interfaces, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Vacuum evaporation, Contact angle, Adsorption, Optics, Chemical engineering, Materials Chemistry, business
Abstract: The hydrophilicity of the SiO 2 (top)/TiO 2 (under) double layer films prepared by vacuum evaporation was investigated. The as-deposited SiO 2 /TiO 2 double layer films showed very good hydrophilicity (water contact angle: ∼0°). Their hydrophilicity, however, is deteriorated by the organic contamination adsorbed on the film but the hydrophilicity can be recovered by UV light irradiation. TOF-SIMS (time-of-flight secondary-ion-mass-spectrometry) measurements revealed that the amount of organic compounds adsorbed on the films decreased with the UV light irradiation. Secondarily, the amount of both Si–OH and Ti–OH groups changed little by the UV light irradiation. Thus, it can be concluded that the hydrophilicity of the SiO 2 /TiO 2 double layer films is due to the stable Si–OH groups and the photo-catalytic TiO 2 underlayer maintains the hydrophilicity of the double layer films by decomposing organic contaminants on the film surface. This SiO 2 /TiO 2 double layer film has been in practical use for the automobiles' exterior rear view mirrors.
Published: 2006
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41. Morphology of the stabilized natural faces of a CdS1−x Sex solid solution

Author: J. Lenzner, Boris Novikov, A. V. Ankudinov, Dietmar Hirsch, A. N. Titkov, M. S. Dunaevskiĭ, R. V. Grigor’ev, T. Komatsu, V. F. Agekyan, and N. R. Grigor’eva
Subjects: Surface (mathematics), Nanostructure, Morphology (linguistics), Materials science, Solid-state physics, Atomic force microscopy, Chemical physics, Exciton, Nanotechnology, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Solid solution
Abstract: The morphology of the stabilized surfaces of CdS1−x Sex crystals exposed to air at room temperature is studied by atomic force microscopy. The characteristic features of the relief of the natural faces of these crystals are described, and the causes of the appearance of these features are discussed. The morphological results are related to the results of the microcathodoluminescence study of surface micro-and nanostructures. This study revealed objects that contribute to exciton emission and, hence, are CdS1−x Sex solid solutions.
Published: 2006
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42. Time Evolution of Asynchronous Value in Synchronization Tapping Task

Author: Yoshihiro Miyake and T. Komatsu
Subjects: Computer science, Asynchronous communication, Real-time computing, Time evolution, Tapping, Time perception, Value (mathematics), Synchronization, Simulation, Task (project management)
Published: 2005
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43. Eating vegetables before carbohydrates improves postprandial glucose excursions

Author: T. Komatsu, Michiaki Fukui, M. Kurokawa, Neiko Ozasa, T. Ozeki, Saeko Imai, and Shizuo Kajiyama
Subjects: Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Type 2 diabetes, Intestinal absorption, Eating, Endocrinology, Internal medicine, Diabetes mellitus, Glucose Intolerance, Vegetables, Dietary Carbohydrates, Internal Medicine, medicine, Humans, Insulin, Letters, Meals, Aged, Meal, business.industry, Area under the curve, Fasting, Postprandial Period, medicine.disease, Postprandial, Diabetes Mellitus, Type 2, Female, business
Abstract: Large fluctuations in blood glucose are reported to promote the micro- and macrovascular complications associated with Type 2 diabetes. Postprandial plasma glucose and glycaemic spikes are more strongly associated with atherosclerosis than fasting plasma glucose or HbA1c level 1. Therefore, safe and effective interventions, including diet, are needed to reduce glycaemic variability and minimize hypoglycaemic events. The continuous glucose monitoring system is capable of detecting hypoglycaemia and hyperglycaemia that may be undetectable by self monitoring blood glucose and HbA1c 2. In particular, the mean amplitude of glycaemic excursions is a significant determinant of overall metabolic control, as well as increased risk of diabetes complications. We reported acute effects of eating vegetables before carbohydrates on postprandial glucose and insulin levels 3 and the long-term glycaemic improvements in patients with Type 2 diabetes 4. The method of the education included nutritional advice given in the form of a simple and easy meal plan of eating vegetables before carbohydrates. In order to reduce postprandial hyperglycaemia, patients were encouraged to consume every meal by eating vegetables prior to carbohydrates. In this study we evaluated whether eating vegetables before carbohydrates could reduce the daily postprandial glucose excursions assessed by continuous glucose monitoring system in Japanese patients with Type 2 diabetes and subjects with normal glucose tolerance. Consecutive patients with Type 2 diabetes were recruited among outpatients regularly attending a diabetes clinic, the Kajiyama Clinic located in Kyoto, Japan, from 2011 to 2012. Diagnosis of diabetes was made according to the World Health Organization criteria. Confirmation of normal glucose tolerance was based on fasting blood glucose < 5.6 mmol/l and 2-h glucose concentration in an oral glucose tolerance test < 7.8 mmol/l. All participants were assigned to perform the continuous glucose monitoring system (CGMS, Medtronic Minimed Gold; Medtronic Minimed, Northridge, CA, USA) for 72 h by eating test meals of vegetables before carbohydrates and carbohydrates before vegetables on the 2nd and the 3rd day in a randomized crossover design. The test meals consisted of rice/bread, meat/fish and 500 g of vegetables, and contained 21 g of dietary fibre and 125.6 kJ kg−1 per day. The energy ratio of protein, fat and carbohydrates was 17, 25 and 58%, respectively. The subjects ate the first dish of vegetables for 5 min, then the main dishes, and consumed rice or bread with a 10-min interval between vegetables and carbohydrates in each meal, and then vice versa. The glucose fluctuations were assessed by the following parameters obtained from the continuous glucose monitoring system and compared between the day of eating vegetables before carbohydrates and the day of eating the carbohydrates before the vegetables: the mean plasma glucose, standard deviation (sd), mean amplitude of glycaemic excursions and the largest amplitude of glycaemic excursions, postprandial plasma glucose, incremental area under the curve 0–3h (IAUC0–3h), and incremental glucose peak. Nineteen outpatients with Type 2 diabetes [men/women 6/13; age 65.5 ± 9.4 years, duration of diabetes 16.4 ± 10.2 years; BMI 22.5 ± 3.1 kg/m2; HbA1c 55.0 ± 10.9 mmol/mol (7.2 ± 1.0%); fasting plasma glucose 8.06 ± 2.67 mmol/l, diet/oral hypoglycaemic agents/insulin + oral hypoglycaemic agents 3/3/13; mean ± sd or n] and 21 subjects with normal glucose tolerance [men/women 2/19; age 29.8 ± 11.3 years; BMI 20.8 ± 3.0 kg/m2; HbA1c 36.0 ± 6.6 mmol/mol (5.4 ± 0.6%); fasting plasma glucose 4.89 ± 0.50 mmol/l] were enrolled in the study. The levels of standard deviation, mean amplitude of glycaemic excursions, largest amplitude of glycaemic excursions, 1-h postprandial plasma glucose of breakfast, IAUC0–3h of lunch and dinner, mean IAUC0–3h and incremental glucose peak were significantly reduced when the participants ate vegetables before carbohydrates compared with the reverse regimen in both subjects with Type 2 diabetes and those with normal glucose tolerance; however, the values of mean plasma glucose were not different in either of the subject groups (Table 1). Two-hour postprandial plasma glucose levels of lunch and dinner, and IAUC0–3h of breakfast were also significantly reduced in patients with Type 2 diabetes, while 1-h postprandial plasma glucose levels of lunch and dinner were significantly decreased in subjects with normal glucose tolerance. The reason for the reduction of postprandial plasma glucose levels by eating vegetables before carbohydrates can be explained, partly, by the dietary fibre content in the vegetables taken before the carbohydrates. Dietary carbohydrates consumed after vegetables were digested slowly and required less insulin for subsequent metabolic disposal 5. Other factors may influence the glycaemic response and digestion of carbohydrates in the small intestine, including the rate of digestion, cooking method, transit time and rate of intestinal absorption. Vegetables given before carbohydrates might stimulate incretin hormone secretion, which leads to the reduction in glycaemic excursions 6. Table 1 Characteristics of glycaemic excursion in subjects with Type 2 diabetes and normal glucose tolerance In this study, we demonstrated that eating vegetables before carbohydrates reduced the postprandial glucose excursions compared with the reverse regimen in both subjects with Type 2 diabetes and those with normal glucose tolerance using continuous glucose monitoring system for the first time. The result of this study is important because eating vegetables before carbohydrates could be a novel method to reduce the incidence of cardiovascular disease 7–10. As one of the educational points in nutrition, the advice to patients with Type 2 diabetes should be to eat vegetables before carbohydrates, and this advice could even be applicable to healthy subjects in order to prevent future cardiovascular events.
Published: 2013
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44. Formation of Ba2TiGe2O8 phase in BaO–TiO2–GeO2 glasses and their optical non-linearities

Author: T. Komatsu, K. Saitoh, Y. Benino, Yoshihiro Takahashi, and T. Fujiwara
Subjects: Crystal, Materials science, Benitoite, Homogeneity (physics), Materials Chemistry, Ceramics and Composites, Analytical chemistry, Nucleation, Mineralogy, Condensed Matter Physics, Single crystal, Stoichiometry, Electronic, Optical and Magnetic Materials
Abstract: Second-order optical non-linearities for the transparent Ba 2 TiGe 2 O 8 (BTG) crystallized glasses with the composition of 40BaO · 20TiO 2 · 40GeO 2 (BTG40), 33.3BaO · 16.7TiO 2 · 50GeO 2 (BTG50) and 30BaO · 15TiO 2 · 55GeO 2 (BTG55) have been examined. A very large d 33 value for a transparent BTG crystallized glass in BTG55 was achieved, i.e., d 33 = 22 ± 3 pm/V, being comparable to that of LiNbO 3 single crystal. The d 33 for BTG50 and BTG40 were measured to be 12 ± 3 pm/V and 7 ± 2 pm/V, respectively. This result indicates that d 33 decreases with GeO 2 concentration, when approaching the glass composition of the stoichiometric BTG crystal. For a larger d 33 value in BTG crystallized glasses, it is considered that the high homogeneity of the oriented surface Ba 2 TiGe 2 O 8 crystalline layer on the crystallized BTG55 glass is accomplished by a suitable amount of benitoite phase of BaTiGe 3 O 9 , which acts a nucleation site for the BTG crystal.
Published: 2004
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45. Effect of intramammary injection of RbG-CSF on milk CL activity of subclinical mastitis cows

Author: Y. Nishijo, R. Horino, Tomoshi Nagata, Masayuki Nakamura, K. Ueda, T. Komatsu, Hideyuki Takahashi, K. Shijimaya, Yuichi Yokomizo, Koichi Hodate, and Kazuaki Takehara
Subjects: business.industry, Immunology, Medicine, Animal Science and Zoology, Subclinical mastitis, business, Food Science
Published: 2004
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46. Autoantibodies from primary biliary cirrhosis patients with anti-p95c antibodies bind to recombinant p97/VCP and inhibitin vitronuclear envelope assembly

Author: M. Shibata, Tsuneyoshi Horigome, H. Hosaka, K. Miyachi, H. Matsushima, Marvin J. Fritzler, Akira Suwa, Tsuneyo Mimori, Raleigh W. Hankins, S. Matsushima, T. Komatsu, Y. Onozuka, Hiroshi Miyakawa, Michito Hirakata, and Yasuhiro Hirano
Subjects: Male, Immunoprecipitation, Immunology, Cell Cycle Proteins, law.invention, Antigen-Antibody Reactions, Valosin Containing Protein, law, Complementary DNA, Clinical Studies, Humans, Immunology and Allergy, Autoantibodies, Adenosine Triphosphatases, Cell Nucleus, Microscopy, Confocal, biology, Liver Cirrhosis, Biliary, Autoantibody, Precipitin, Precipitin Tests, In vitro, Immunodiffusion, Liver, biology.protein, Recombinant DNA, Female, Antibody
Abstract: SUMMARYWe have reported previously that p95c, a novel 95-kDa cytosolic protein, was the target of autoantibodies in sera of patients with autoimmune hepatic diseases. We studied 30 sera that were shown previously to immunoprecipitate a 95 kDa protein from [35S]-methionine-labelled HeLa lysates and had a specific precipitin band in immunodiffusion. Thirteen sera were available to test the ability of p95c antibodies to inhibit nuclear envelope assembly in an in vitro assay in which confocal fluorescence microscopy was also used to identify the stages at which nuclear assembly was inhibited. The percentage inhibition of nuclear envelope assembly of the 13 sera ranged from 7% to 99% and nuclear envelope assembly and the swelling of nucleus was inhibited at several stages. The percentage inhibition of nuclear assembly was correlated with the titre of anti-p95c as determined by immunodiffusion. To confirm the identity of this autoantigen, we used a full-length cDNA of the p97/valosin-containing protein (VCP) to produce a radiolabelled recombinant protein that was then used in an immunoprecipitation (IP) assay. Our study demonstrated that 12 of the 13 (93%) human sera with antibodies to p95c immunoprecipitated recombinant p97/VCP. Because p95c and p97 have similar molecular masses and cell localization, and because the majority of sera bind recombinant p97/VCP and anti-p95c antibodies inhibit nuclear assembly, this is compelling evidence that p95c and p97/VCP are identical.
Published: 2004
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47. The posterior cruciate ligament during flexion of the normal knee

Author: Antonin Sosna, Michael A.R. Freeman, S. Nakagawa, A. Williams, V. Pinskerova, T. Komatsu, and P. Johal
Subjects: Adult, Male, musculoskeletal diseases, medicine.medical_specialty, Knee Joint, Cadaver, Humans, Medicine, Orthopedics and Sports Medicine, Tibial rotation, Range of Motion, Articular, Orthodontics, Analysis of Variance, business.industry, musculoskeletal system, Magnetic Resonance Imaging, Biomechanical Phenomena, body regions, medicine.anatomical_structure, Posterior cruciate ligament, Orthopedic surgery, Ligament, Squatting position, Female, Posterior Cruciate Ligament, Surgery, business, Range of motion, human activities
Abstract: The posterior cruciate ligament (PCL) was imaged by MRI throughout flexion in neutral tibial rotation in six cadaver knees, which were also dissected, and in 20 unloaded and 13 loaded living (squatting) knees. The appearance of the ligament was the same in all three groups. In extension the ligament is curved concave-forwards. It is straight, fully out-to-length and approaching vertical from 60° to 120°, and curves convex-forwards over the roof of the intercondylar notch in full flexion. Throughout flexion the length of the ligament does not change, but the separations of its attachments do. We conclude that the PCL is not loaded in the unloaded cadaver knee and therefore, since its appearance in all three groups is the same, that it is also unloaded in the living knee during flexion. The posterior fibres may be an exception in hyperextension, probably being loaded either because of posterior femoral lift-off or because of the forward curvature of the PCL. These conclusions relate only to everyday life: none may be drawn with regard to more strenuous activities such as sport or in trauma.
Published: 2004
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48. 86th Annual Meeting of the Swiss Society for Dermatology and Venereology: Abstracts

Author: Juliette Mazereeuw-Hautier, K. Scharffetter-Kochanek, Stamatis Gregoriou, Efstratios Patsouris, Li-Cheng Yang, Ludwine Messiaen, Jürgen Bauer, Tadashi Tezuka, C. Sunderkötter, Claudia Vente, S. Tajima, M. Heenen, I. Fumal, L.T. Sumanovski, Gérald Pierard, B.R. Yelikar, Claudine Piérard-Franchimont, Thomas Eigentler, Rudolf Happle, Christine Neumann, Keiko Hashimoto, T. Simonart, Rieko Isogai, Kyriaki Aroni, P.L. Bigliardi, Ignacio García-Doval, Rainer Rupprecht, Vito Ingordo, Akihisa Kanamaru, Luigi Naldi, B. Kreft, Yasuhiro Maeda, Y. Ohnishi, Stefania Fracchiolla, Andreas C. Lazaris, Arun C Inamadar, Hiroyuki Suzuki, M. Bigliardi-Qi, Ralph M. Trüeb, Pascale Quatresooz, Caroline van den Broecke, Aparna Palit, M. Grassi, R. Hinrichs, Tetsutaro Sata, Hiroyuki Hara, I. Uhoda, Carlo Tomasini, Emmanouil Agapitos, Sandra Janssens, T. Komatsu, Ulrich M. Caroli, Manuel Cruces, Nikoleta Zakopoulou, Mario Pippione, Toshihiko Matsukura, Akira Kawada, Bruno Colecchia, Wei-Hsin Juan, S. Büchner, T. Rufli, J. Rampf, Jean-Louis Bonafé, M. Merkel, Ayano Honda, Gisela Metzler, Hong-Shang Hong, Frank C. Powell, M. Yajima, Panagiotis G. Stavropoulos, N. Fujimoto, Eugenia Tsagroni, Peter Radny, Hans Bertsch, Jean-Marie Naeyaert, W.C. Marsch, George Kontochristopoulos, A. Kamin, Claus Garbe, A. Essig, J. Wohlrab, Yoshinori Aragane, and Sofie De Schepper
Subjects: medicine.medical_specialty, Venereology, business.industry, Medicine, Dermatology, business
Published: 2004
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49. Hybrid finite analytic solutions of shallow water circulation

Author: Huai Wen-xin, T. Komatsu, and Y. Peter Sheng
Subjects: Seiche, Meteorology, Oscillation, Applied Mathematics, Mechanical Engineering, Flow (psychology), Mechanics, Waves and shallow water, Circulation (fluid dynamics), Mechanics of Materials, Analytic element method, Bathymetry, Sigma coordinate system, Physics::Atmospheric and Oceanic Physics, Geology
Abstract: The hybrid finite analytic (HFA) method is a kind of numerical scheme in rectangular element. In order to simulate the shallow circulation in irregular bathymetry by HFA scheme, the model in sigma coordinate system was obtained. The model has been tested against three cases: 1) Wind induced circulation; 2) Density driven circulation and 3) Seiche oscillation. The results obtained in the present study compare well with those obtained from the corresponding analytical solutions under idealized for the above three cases. The hybrid finite analytic method and the circulation model in sigma coordinate system can be used calculate the flow and water quality in estuaries and coastal waters.
Published: 2003
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50. Central and peripheral concentrations of tumor necrosis factor-α in Chinese Meishan pigs stimulated with lipopolysaccharide1,2

Author: Ryosuke Sakumoto, Etsuko Kasuya, T. Komatsu, and T. Akita
Subjects: Pituitary gland, medicine.medical_specialty, Lipopolysaccharide, media_common.quotation_subject, Central nervous system, General Medicine, Biology, Urination, chemistry.chemical_compound, medicine.anatomical_structure, Endocrinology, chemistry, Hypothalamus, Internal medicine, Genetics, medicine, Animal Science and Zoology, Tumor necrosis factor alpha, Biological regulation, Intramuscular injection, Food Science, media_common
Abstract: The objective of this study was to investigate the presence of tumor necrosis factor-alpha (TNF-alpha) in the central nervous system and the effects of lipopolysaccharide on central and peripheral concentrations of TNF-alpha, behavioral conditions (standing or lying), elimination scores (defecation or urination), rectal temperature, and food intake (as-fed basis) in Chinese Meishan pigs. Intravenous injections of lipopolysaccharide resulted in increased (P < 0.05) plasma concentrations of TNF-alpha and cortisol. Although urination was not affected by the administration of lipopolysaccharide, defecation was stimulated (P < 0.05). Lipopolysaccharide increased (P < 0.05) rectal temperature and standing rate, and inhibited (P < 0.05) food intake in pigs. To determine whether TNF-alpha is present in the porcine central nervous system as well as in peripheral blood, TNF-alpha and its specific transcripts in brain tissues (hypothalamus, amygdala, or hippocampus) and the pituitary were determined. The abundance of TNF-alpha messenger RNA and immunoreactive TNF-alpha were observed in all tissues, and the concentrations of TNF-alpha were increased (P < 0.05) by the intramuscular injection of lipopolysaccharide. These results suggest that TNF-alpha is present in the central nervous system, and plays some roles in its biological regulation in Chinese Meishan pigs.
Published: 2003
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