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1. Combined Pre-supernova Alert System with KamLAND and Super-Kamiokande

Author: S. Abe, M. Eizuka, S. Futagi, A. Gando, Y. Gando, S. Goto, T. Hachiya, K. Hata, K. Ichimura, S. Ieki, H. Ikeda, K. Inoue, K. Ishidoshiro, Y. Kamei, N. Kawada, Y. Kishimoto, M. Koga, M. Kurasawa, T. Mitsui, H. Miyake, D. Morita, T. Nakahata, R. Nakajima, K. Nakamura, R. Nakamura, J. Nakane, H. Ozaki, K. Saito, T. Sakai, I. Shimizu, J. Shirai, K. Shiraishi, R. Shoji, A. Suzuki, A. Takeuchi, K. Tamae, H. Watanabe, K. Watanabe, S. Yoshida, S. Umehara, K. Fushimi, K. Kotera, Y. Urano, B. E. Berger, B. K. Fujikawa, J. G. Learned, J. Maricic, Z. Fu, J. Smolsky, L. A. Winslow, Y. Efremenko, H. J. Karwowski, D. M. Markoff, W. Tornow, S. Dell’Oro, T. O’Donnell, J. A. Detwiler, S. Enomoto, M. P. Decowski, K. M. Weerman, C. Grant, H. Song, A. Li, S. N. Axani, M. Garcia, The KamLAND Collaboration, K. Abe, C. Bronner, Y. Hayato, K. Hiraide, K. Hosokawa, K. Ieki, M. Ikeda, J. Kameda, Y. Kanemura, R. Kaneshima, Y. Kashiwagi, Y. Kataoka, S. Miki, S. Mine, M. Miura, S. Moriyama, M. Nakahata, Y. Nakano, S. Nakayama, Y. Noguchi, K. Sato, H. Sekiya, H. Shiba, K. Shimizu, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, H. Tanaka, T. Yano, S. Han, T. Kajita, K. Okumura, T. Tashiro, T. Tomiya, X. Wang, P. Fernandez, L. Labarga, N. Ospina, B. Zaldivar, B. W. Pointon, E. Kearns, J. L. Raaf, L. Wan, T. Wester, J. Bian, N. J. Griskevich, M. B. Smy, H. W. Sobel, V. Takhistov, A. Yankelevich, J. Hill, M. C. Jang, S. H. Lee, D. H. Moon, R. G. Park, B. Bodur, K. Scholberg, C. W. Walter, A. Beauchêne, O. Drapier, A. Giampaolo, Th. A. Mueller, A. D. Santos, P. Paganini, B. Quilain, R. Rogly, T. Nakamura, J. S. Jang, L. N. Machado, K. Choi, N. Iovine, S. Cao, L. H. V. Anthony, D. Martin, N. W. Prouse, M. Scott, Y. Uchida, V. Berardi, N. F. Calabria, M. G. Catanesi, E. Radicioni, A. Langella, G. De Rosa, G. Collazuol, M. Feltre, F. Iacob, M. Mattiazzi, L. Ludovici, M. Gonin, L. Périssé, G. Pronost, C. Fujisawa, S. Horiuchi, M. Kobayashi, Y. M. Liu, Y. Maekawa, Y. Nishimura, R. Okazaki, R. Akutsu, M. Friend, T. Hasegawa, T. Ishida, T. Kobayashi, M. Jakkapu, T. Matsubara, T. Nakadaira, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, A. Portocarrero Yrey, N. Bhuiyan, G. T. Burton, F. Di Lodovico, J. Gao, A. Goldsack, T. Katori, J. Migenda, R. M. Ramsden, Z. Xie, S. Zsoldos, A. T. Suzuki, Y. Takagi, Y. Takeuchi, H. Zhong, J. Feng, L. Feng, J. R. Hu, Z. Hu, M. Kawaue, T. Kikawa, M. Mori, T. Nakaya, R. A. Wendell, K. Yasutome, S. J. Jenkins, N. McCauley, P. Mehta, A. Tarrant, M. J. Wilking, Y. Fukuda, Y. Itow, H. Menjo, K. Ninomiya, Y. Yoshioka, J. Lagoda, M. Mandal, P. Mijakowski, Y. S. Prabhu, J. Zalipska, M. Jia, J. Jiang, W. Shi, C. Yanagisawa, M. Harada, Y. Hino, H. Ishino, Y. Koshio, F. Nakanishi, S. Sakai, T. Tada, T. Tano, T. Ishizuka, G. Barr, D. Barrow, L. Cook, S. Samani, D. Wark, A. Holin, F. Nova, S. Jung, B. S. Yang, J. Y. Yang, J. Yoo, J. E. P. Fannon, L. Kneale, M. Malek, J. M. McElwee, M. D. Thiesse, L. F. Thompson, S. T. Wilson, H. Okazawa, S. M. Lakshmi, S. B. Kim, E. Kwon, J. W. Seo, I. Yu, A. K. Ichikawa, K. D. Nakamura, S. Tairafune, K. Nishijima, A. Eguchi, K. Nakagiri, Y. Nakajima, S. Shima, N. Taniuchi, E. Watanabe, M. Yokoyama, P. de Perio, S. Fujita, C. Jesús-Valls, K. Martens, K. M. Tsui, M. R. Vagins, J. Xia, S. Izumiyama, M. Kuze, R. Matsumoto, K. Terada, R. Asaka, M. Ishitsuka, H. Ito, Y. Ommura, N. Shigeta, M. Shinoki, K. Yamauchi, T. Yoshida, R. Gaur, V. Gousy-Leblanc, M. Hartz, A. Konaka, X. Li, S. Chen, B. D. Xu, A. Q. Zhang, B. Zhang, M. Posiadala-Zezula, S. B. Boyd, R. Edwards, D. Hadley, M. Nicholson, M. O’Flaherty, B. Richards, A. Ali, B. Jamieson, S. Amanai, Ll. Marti, A. Minamino, R. Shibayama, S. Suzuki, and The Super-Kamiokande Collaboration
Subjects: Particle astrophysics, Neutrino astronomy, Core-collapse supernovae, Astrophysics, QB460-466
Abstract: Preceding a core-collapse supernova (CCSN), various processes produce an increasing amount of neutrinos of all flavors characterized by mounting energies from the interior of massive stars. Among them, the electron antineutrinos are potentially detectable by terrestrial neutrino experiments such as KamLAND and Super-Kamiokande (SK) via inverse beta decay interactions. Once these pre-supernova (pre-SN) neutrinos are observed, an early warning of the upcoming CCSN can be provided. In light of this, KamLAND and SK, both located in the Kamioka mine in Japan, have been monitoring pre-SN neutrinos since 2015 and 2021, respectively. Recently, we performed a joint study between KamLAND and SK on pre-SN neutrino detection. A pre-SN alert system combining the KamLAND detector and the SK detector was developed and put into operation, which can provide a supernova alert to the astrophysics community. Fully leveraging the complementary properties of these two detectors, the combined alert is expected to resolve a pre-SN neutrino signal from a 15 M _⊙ star within 510 pc of the Earth at a significance level corresponding to a false alarm rate of no more than 1 per century. For a Betelgeuse-like model with optimistic parameters, it can provide early warnings up to 12 hr in advance.
Published: 2024
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2. Performance of SK-Gd’s Upgraded Real-time Supernova Monitoring System

Author: Y. Kashiwagi, K. Abe, C. Bronner, Y. Hayato, K. Hiraide, K. Hosokawa, K. Ieki, M. Ikeda, J. Kameda, Y. Kanemura, R. Kaneshima, Y. Kataoka, S. Miki, S. Mine, M. Miura, S. Moriyama, Y. Nakano, M. Nakahata, S. Nakayama, Y. Noguchi, K. Sato, H. Sekiya, H. Shiba, K. Shimizu, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, H. Tanaka, T. Yano, S. Han, T. Kajita, K. Okumura, T. Tashiro, T. Tomiya, X. Wang, S. Yoshida, P. Fernandez, L. Labarga, N. Ospina, B. Zaldivar, B. W. Pointon, E. Kearns, J. L. Raaf, L. Wan, T. Wester, J. Bian, N. J. Griskevich, S. Locke, M. B. Smy, H. W. Sobel, V. Takhistov, A. Yankelevich, J. Hill, M. C. Jang, S. H. Lee, D. H. Moon, R. G. Park, B. Bodur, K. Scholberg, C. W. Walter, A. Beauchêne, O. Drapier, A. Giampaolo, Th. A. Mueller, A. D. Santos, P. Paganini, B. Quilain, R. Rogly, T. Nakamura, J. S. Jang, L. N. Machado, J. G. Learned, K. Choi, N. Iovine, S. Cao, L. H. V. Anthony, D. Martin, N. W. Prouse, M. Scott, A. A. Sztuc, Y. Uchida, V. Berardi, M. G. Catanesi, E. Radicioni, N. F. Calabria, A. Langella, G. De Rosa, G. Collazuol, F. Iacob, M. Mattiazzi, L. Ludovici, M. Gonin, L. Périssé, G. Pronost, C. Fujisawa, Y. Maekawa, Y. Nishimura, R. Okazaki, R. Akutsu, M. Friend, T. Hasegawa, T. Ishida, T. Kobayashi, M. Jakkapu, T. Matsubara, T. Nakadaira, K. Nakamura, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, N. Bhuiyan, G. T. Burton, F. Di Lodovico, J. Gao, A. Goldsack, T. Katori, J. Migenda, R. M. Ramsden, Z. Xie, S. Zsoldos, A. T. Suzuki, Y. Takagi, Y. Takeuchi, H. Zhong, J. Feng, L. Feng, J. R. Hu, Z. Hu, M. Kawaue, T. Kikawa, M. Mori, T. Nakaya, R. A. Wendell, K. Yasutome, S. J. Jenkins, N. McCauley, P. Mehta, A. Tarrant, Y. Fukuda, Y. Itow, H. Menjo, K. Ninomiya, Y. Yoshioka, J. Lagoda, S. M. Lakshmi, M. Mandal, P. Mijakowski, Y. S. Prabhu, J. Zalipska, M. Jia, J. Jiang, C. K. Jung, W. Shi, M. J. Wilking, C. Yanagisawa, M. Harada, Y. Hino, H. Ishino, Y. Koshio, F. Nakanishi, S. Sakai, T. Tada, T. Tano, T. Ishizuka, G. Barr, D. Barrow, L. Cook, S. Samani, D. Wark, A. Holin, F. Nova, S. Jung, B. S. Yang, J. Y. Yang, J. Yoo, J. E. P. Fannon, L. Kneale, M. Malek, J. M. McElwee, M. D. Thiesse, L. F. Thompson, S. T. Wilson, H. Okazawa, S. B. Kim, E. Kwon, J. W. Seo, I. Yu, A. K. Ichikawa, K. D. Nakamura, S. Tairafune, K. Nishijima, A. Eguchi, K. Nakagiri, Y. Nakajima, S. Shima, N. Taniuchi, E. Watanabe, M. Yokoyama, P. de Perio, S. Fujita, C. Jesús-Valls, K. Martens, K. M. Tsui, M. R. Vagins, J. Xia, M. Kuze, S. Izumiyama, R. Matsumoto, M. Ishitsuka, H. Ito, Y. Ommura, N. Shigeta, M. Shinoki, K. Yamauchi, T. Yoshida, R. Gaur, V. Gousy-Leblanc, M. Hartz, A. Konaka, X. Li, S. Chen, B. D. Xu, B. Zhang, M. Posiadala-Zezula, S. B. Boyd, R. Edwards, D. Hadley, M. Nicholson, M. O’Flaherty, B. Richards, A. Ali, B. Jamieson, S. Amanai, Ll. Marti, A. Minamino, S. Suzuki, and The Super-Kamiokande Collaboration
Subjects: Core-collapse supernovae, Supernova neutrinos, Particle astrophysics, Astrophysics, QB460-466
Abstract: Among multimessenger observations of the next Galactic core-collapse supernova, Super-Kamiokande (SK) plays a critical role in detecting the emitted supernova neutrinos, determining the direction to the supernova (SN), and notifying the astronomical community of these observations in advance of the optical signal. In 2022, SK has increased the gadolinium dissolved in its water target (SK-Gd) and has achieved a Gd concentration of 0.033%, resulting in enhanced neutron detection capability, which in turn enables more accurate determination of the supernova direction. Accordingly, SK-Gd’s real-time supernova monitoring system has been upgraded. SK_SN Notice, a warning system that works together with this monitoring system, was released on 2021 December 13, and is available through GCN Notices. When the monitoring system detects an SN-like burst of events, SK_SN Notice will automatically distribute an alarm with the reconstructed direction to the supernova candidate within a few minutes. In this paper, we present a systematic study of SK-Gd’s response to a simulated Galactic SN. Assuming a supernova situated at 10 kpc, neutrino fluxes from six supernova models are used to characterize SK-Gd’s pointing accuracy using the same tools as the online monitoring system. The pointing accuracy is found to vary from 3° to 7° depending on the models. However, if the supernova is closer than 10 kpc, SK_SN Notice can issue an alarm with three-degree accuracy, which will benefit follow-up observations by optical telescopes with large fields of view.
Published: 2024
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3. Search for Astrophysical Electron Antineutrinos in Super-Kamiokande with 0.01% Gadolinium-loaded Water

Author: M. Harada, K. Abe, C. Bronner, Y. Hayato, K. Hiraide, K. Hosokawa, K. Ieki, M. Ikeda, J. Kameda, Y. Kanemura, R. Kaneshima, Y. Kashiwagi, Y. Kataoka, S. Miki, S. Mine, M. Miura, S. Moriyama, Y. Nakano, M. Nakahata, S. Nakayama, Y. Noguchi, K. Okamoto, K. Sato, H. Sekiya, H. Shiba, K. Shimizu, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, A. Takenaka, H. Tanaka, S. Watanabe, T. Yano, S. Han, T. Kajita, K. Okumura, T. Tashiro, T. Tomiya, X. Wang, S. Yoshida, G. D. Megias, P. Fernandez, L. Labarga, N. Ospina, B. Zaldivar, B. W. Pointon, E. Kearns, J. L. Raaf, L. Wan, T. Wester, J. Bian, N. J. Griskevich, S. Locke, M. B. Smy, H. W. Sobel, V. Takhistov, A. Yankelevich, J. Hill, S. H. Lee, D. H. Moon, R. G. Park, B. Bodur, K. Scholberg, C. W. Walter, A. Beauchêne, O. Drapier, A. Giampaolo, Th. A. Mueller, A. D. Santos, P. Paganini, B. Quilain, T. Ishizuka, T. Nakamura, J. S. Jang, J. G. Learned, K. Choi, N. Iovine, S. Cao, L. H. V. Anthony, D. Martin, M. Scott, A. A. Sztuc, Y. Uchida, V. Berardi, M. G. Catanesi, E. Radicioni, N. F. Calabria, A. Langella, L. N. Machado, G. De Rosa, G. Collazuol, F. Iacob, M. Lamoureux, M. Mattiazzi, L. Ludovici, M. Gonin, G. Pronost, C. Fujisawa, Y. Maekawa, Y. Nishimura, R. Okazaki, R. Akutsu, M. Friend, T. Hasegawa, T. Ishida, T. Kobayashi, M. Jakkapu, T. Matsubara, T. Nakadaira, K. Nakamura, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, N. Bhuiyan, G. T. Burton, F. Di Lodovico, J. Gao, A. Goldsack, T. Katori, J. Migenda, Z. Xie, S. Zsoldos, Y. Kotsar, H. Ozaki, A. T. Suzuki, Y. Takagi, Y. Takeuchi, J. Feng, L. Feng, J. R. Hu, Z. Hu, T. Kikawa, M. Mori, T. Nakaya, R. A. Wendell, K. Yasutome, S. J. Jenkins, N. McCauley, P. Mehta, A. Tarrant, Y. Fukuda, Y. Itow, H. Menjo, K. Ninomiya, J. Lagoda, S. M. Lakshmi, M. Mandal, P. Mijakowski, Y. S. Prabhu, J. Zalipska, M. Jia, J. Jiang, C. K. Jung, M. J. Wilking, C. Yanagisawa, Y. Hino, H. Ishino, H. Kitagawa, Y. Koshio, F. Nakanishi, S. Sakai, T. Tada, T. Tano, G. Barr, D. Barrow, L. Cook, S. Samani, D. Wark, A. Holin, F. Nova, B. S. Yang, J. Y. Yang, J. Yoo, J. E. P. Fannon, L. Kneale, M. Malek, J. M. McElwee, M. D. Thiesse, L. F. Thompson, S. T. Wilson, H. Okazawa, S. B. Kim, E. Kwon, J. W. Seo, I. Yu, A. K. Ichikawa, K. D. Nakamura, S. Tairafune, K. Nishijima, K. Nakagiri, Y. Nakajima, S. Shima, N. Taniuchi, E. Watanabe, M. Yokoyama, P. de Perio, K. Martens, K. M. Tsui, M. R. Vagins, J. Xia, M. Kuze, S. Izumiyama, R. Matsumoto, M. Ishitsuka, H. Ito, T. Kinoshita, Y. Ommura, N. Shigeta, M. Shinoki, T. Suganuma, K. Yamauchi, J. F. Martin, H. A. Tanaka, T. Towstego, R. Gaur, V. Gousy-Leblanc, M. Hartz, A. Konaka, X. Li, N. W. Prouse, S. Chen, B. D. Xu, B. Zhang, M. Posiadala-Zezula, S. B. Boyd, R. Edwards, D. Hadley, M. Nicholson, M. O’Flaherty, B. Richards, A. Ali, B. Jamieson, Ll. Marti, A. Minamino, G. Pintaudi, S. Sano, S. Suzuki, K. Wada, and The Super-Kamiokande Collaboration
Subjects: Supernova neutrinos, Neutrino astronomy, Astrophysics, QB460-466
Abstract: We report the first search result for the flux of astrophysical electron antineutrinos for energies ${ \mathcal O }(10)\,\mathrm{MeV}$ in the gadolinium-loaded Super-Kamiokande (SK) detector. In 2020 June, gadolinium was introduced to the ultrapure water of the SK detector in order to detect neutrons more efficiently. In this new experimental phase, SK-Gd, we can search for electron antineutrinos via inverse beta decay with efficient background rejection thanks to the high efficiency of the neutron tagging technique. In this paper, we report the result for the initial stage of SK-Gd, during 2020 August 26, and 2022 June 1 with a 22.5 × 552 kton · day exposure at 0.01% Gd mass concentration. No significant excess over the expected background in the observed events is found for the neutrino energies below 31.3 MeV. Thus, the flux upper limits are placed at the 90% confidence level. The limits and sensitivities are already comparable with the previous SK result with pure water (22.5 × 2970 kton · day) owing to the enhanced neutron tagging. Operation with Gd increased to 0.03% started in 2022 June.
Published: 2023
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4. Identifying Problems in the Morphological Evaluation of Bronchoalveolar Lavage

Author: Y. Waseda, A. Takeuchi, Y. Hosokawa, S. Kimura, K. Yamaoka, M. Mitsui, A. Shimada, M. Yamaguchi, T. Sonoda, C. Honjo, M. Kadowaki, Y. Umeda, M. Anzai, S. Watanabe, A. Miyamoto, T. Oka, H. Ishii, T. Isobe, and T. Ishizuka
Published: 2023

5. MEASUREMENT OF PHASE DISTRIBUTION PHENOMENA IN HIGH PRESSURE STEAM-WATER TWO PHASE FLOW

Author: T. Narabayashi, Shinichi Morooka, T. Kagawa, T. Ishizuka, A. Hoshide, and T. Ishiyama
Published: 2023

6. Search for supernova bursts in Super-Kamiokande IV

Author: M. Mori, K. Abe, Y. Hayato, K. Hiraide, K. Ieki, M. Ikeda, S. Imaizumi, J. Kameda, Y. Kanemura, R. Kaneshima, Y. Kashiwagi, Y. Kataoka, S. Miki, S. Mine, M. Miura, S. Moriyama, Y. Nagao, M. Nakahata, Y. Nakano, S. Nakayama, Y. Noguchi, T. Okada, K. Okamoto, A. Orii, K. Sato, H. Sekiya, H. Shiba, K. Shimizu, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, A. Takenaka, H. Tanaka, T. Tomiya, S. Watanabe, T. Yano, S. Yoshida, S. Han, T. Kajita, K. Okumura, T. Tashiro, X. Wang, J. Xia, G. D. Megias, D. Bravo-Berguño, P. Fernandez, L. Labarga, N. Ospina, B. Zaldivar, S. Zsoldos, B. W. Pointon, F. D. M. Blaszczyk, E. Kearns, J. L. Raaf, J. L. Stone, L. Wan, T. Wester, J. Bian, N. J. Griskevich, W. R. Kropp, S. Locke, M. B. Smy, H. W. Sobel, V. Takhistov, Yankelevich A., J. Hill, J. Y. Kim, I. T. Lim, R. G. Park, B. Bodur, K. Scholberg, C. W. Walter, L. Bernard, A. Coffani, O. Drapier, S. El Hedri, A. Giampaolo, Th. A. Mueller, P. Paganini, B. Quilain, A. D. Santos, T. Ishizuka, T. Nakamura, J. S. Jang, J. G. Learned, L. H. V. Anthony, D. Martin, M. Scott, A. A. Sztuc, Y. Uchida, V. Berardi, M. G. Catanesi, E. Radicioni, N. F. Calabria, L. N. Machado, G. De Rosa, G. Collazuol, F. Iacob, M. Lamoureux, M. Mattiazzi, L. Ludovici, M. Gonin, G. Pronost, Y. Maekawa, Y. Nishimura, C. Fujisawa, M. Friend, T. Hasegawa, T. Ishida, T. Kobayashi, M. Jakkapu, T. Matsubara, T. Nakadaira, K. Nakamura, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, H. Ozaki, T. Shiozawa, A. T. Suzuki, Y. Takeuchi, S. Yamamoto, Y. Kotsar, Y. Ashida, C. Bronner, J. Feng, S. Hirota, T. Kikawa, T. Nakaya, R. A. Wendell, K. Yasutome, N. McCauley, P. Mehta, K. M. Tsui, Y. Fukuda, Y. Itow, H. Menjo, K. Ninomiya, T. Niwa, M. Tsukada, J. Lagoda, S. M. Lakshmi, P. Mijakowski, J. Zalipska, M. Mandal, Y. S. Prabhu, J. Jiang, C. K. Jung, C. Vilela, M. J. Wilking, C. Yanagisawa, M. Jia, K. Hagiwara, M. Harada, T. Horai, H. Ishino, S. Ito, H. Kitagawa, Y. Koshio, W. Ma, F. Nakanishi, N. Piplani, S. Sakai, G. Barr, D. Barrow, L. Cook, S. Samani, D. Wark, F. Nova, T. Boschi, J. Gao, A. Goldsack, T. Katori, F. Di Lodovico, J. Migenda, M. Taani, J. Y. Yang, S. J. Jenkins, M. Malek, J. M. McElwee, O. Stone, M. D. Thiesse, L. F. Thompson, H. Okazawa, S. B. Kim, J. W. Seo, I. Yu, K. Nishijima, M. Koshiba, K. Nakagiri, Y. Nakajima, K. Iwamoto, N. Taniuchi, M. Yokoyama, K. Martens, P. de Perio, M. R. Vagins, M. Kuze, S. Izumiyama, T. Yoshida, M. Inomoto, M. Ishitsuka, H. Ito, T. Kinoshita, R. Matsumoto, K. Ohta, Y. Ommura, N. Shigeta, M. Shinoki, T. Suganuma, K. Yamauchi, J. F. Martin, H. A. Tanaka, T. Towstego, R. Akutsu, V. Gousy-Leblanc, M. Hartz, A. Konaka, N. W. Prouse, S. Chen, B. D. Xu, B. Zhang, M. Posiadala-Zezula, D. Hadley, M. Nicholson, M. O’Flaherty, B. Richards, A. Ali, B. Jamieson, J. Walker, Ll. Marti, A. Minamino, G. Pintaudi, R. Sasaki, S. Sano, S. Suzuki, K. Wada, S. Cao, A. ichikawa, K. D. Nakamura, S. Tairafune, K. Choi, Mori, M., Abe, K., Hayato, Y., Hiraide, K., Ieki, K., Ikeda, M., Imaizumi, S., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nagao, Y., Nakahata, M., Nakano, Y., Nakayama, S., Noguchi, Y., Okada, T., Okamoto, K., Orii, A., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Tomiya, T., Watanabe, S., Yano, T., Yoshida, S., Han, S., Kajita, T., Okumura, K., Tashiro, T., Wang, X., Xia, J., Megias, G. D., Bravo-Bergu??o, D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Zsoldos, S., Pointon, B. W., Blaszczyk, F. D. M., Kearns, E., Raaf, J. L., Stone, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Kropp, W. R., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., A., Yankelevich, Hill, J., Kim, J. Y., Lim, I. T., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Bernard, L., Coffani, A., Drapier, O., El Hedri, S., Giampaolo, A., Mueller, Th. A., Paganini, P., Quilain, B., Santos, A. D., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Anthony, L. H. V., Martin, D., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Nascimento Machado, L., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Pronost, G., Maekawa, Y., Nishimura, Y., Fujisawa, C., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Ozaki, H., Shiozawa, T., Suzuki, A. T., Takeuchi, Y., Yamamoto, S., Kotsar, Y., Ashida, Y., Bronner, C., Feng, J., Hirota, S., Kikawa, T., Nakaya, T., Wendell, R. A., Yasutome, K., Mccauley, N., Mehta, P., Tsui, K. M., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Niwa, T., Tsukada, M., Lagoda, J., Lakshmi, S. M., Mijakowski, P., Zalipska, J., Mandal, M., Prabhu, Y. S., Jiang, J., Jung, C. K., Vilela, C., Wilking, M. J., Yanagisawa, C., Jia, M., Hagiwara, K., Harada, M., Horai, T., Ishino, H., Ito, S., Kitagawa, H., Koshio, Y., Ma, W., Nakanishi, F., Piplani, N., Sakai, S., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Nova, F., Boschi, T., Gao, J., Goldsack, A., Katori, T., Di Lodovico, F., Migenda, J., Taani, M., Yang, J. Y., Jenkins, S. J., Malek, M., Mcelwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Okazawa, H., Kim, S. B., Seo, J. W., Yu, I., Nishijima, K., Koshiba, M., Nakagiri, K., Nakajima, Y., Iwamoto, K., Taniuchi, N., Yokoyama, M., Martens, K., de Perio, P., Vagins, M. R., Kuze, M., Izumiyama, S., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Kinoshita, T., Matsumoto, R., Ohta, K., Ommura, Y., Shigeta, N., Shinoki, M., Suganuma, T., Yamauchi, K., Martin, J. F., Tanaka, H. A., Towstego, T., Akutsu, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Prouse, N. W., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Hadley, D., Nicholson, M., O???flaherty, M., Richards, B., Ali, A., Jamieson, B., Walker, J., Marti, Ll., Minamino, A., Pintaudi, G., Sasaki, R., Sano, S., Suzuki, S., Wada, K., Cao, S., Ichikawa, A., Nakamura, K. D., Tairafune, S., and Choi, K.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, High Energy Physics - Experiment, Supernova neutrinos, High Energy Physics - Experiment (hep-ex), Space and Planetary Science, Core-collapse supernovae Supernova neutrinos Particle astrophysics, Core-collapse supernovae, Particle astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics::Galaxy Astrophysics
Abstract: Super-Kamiokande has been searching for neutrino bursts characteristic of core-collapse supernovae continuously, in real time, since the start of operations in 1996. The present work focuses on detecting more distant supernovae whose event rate may be too small to trigger in real time, but may be identified using an offline approach. The analysis of data collected from 2008 to 2018 found no evidence of distant supernovae bursts. This establishes an upper limit of 0.29 yr−1 on the rate of core-collapse supernovae out to 100 kpc at 90% C.L. For supernovae that fail to explode and collapse directly to black holes the limit reaches to 300 kpc.
Published: 2022

7. First gadolinium loading to Super-Kamiokande

Author: K. Abe, C. Bronner, Y. Hayato, K. Hiraide, M. Ikeda, S. Imaizumi, J. Kameda, Y. Kanemura, Y. Kataoka, S. Miki, M. Miura, S. Moriyama, Y. Nagao, M. Nakahata, S. Nakayama, T. Okada, K. Okamoto, A. Orii, G. Pronost, H. Sekiya, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, A. Takenaka, H. Tanaka, S. Watanabe, T. Yano, S. Han, T. Kajita, K. Okumura, T. Tashiro, J. Xia, G.D. Megias, D. Bravo-Berguño, L. Labarga, Ll. Marti, B. Zaldivar, B.W. Pointon, F.d.M. Blaszczyk, E. Kearns, J.L. Raaf, J.L. Stone, L. Wan, T. Wester, J. Bian, N.J. Griskevich, W.R. Kropp, S. Locke, S. Mine, M.B. Smy, H.W. Sobel, V. Takhistov, J. Hill, J.Y. Kim, I.T. Lim, R.G. Park, B. Bodur, K. Scholberg, C.W. Walter, L. Bernard, A. Coffani, O. Drapier, S. El Hedri, A. Giampaolo, M. Gonin, Th.A. Mueller, P. Paganini, B. Quilain, T. Ishizuka, T. Nakamura, J.S. Jang, J.G. Learned, L.H.V. Anthony, D. Martin, M. Scott, A.A. Sztuc, Y. Uchida, S. Cao, V. Berardi, M.G. Catanesi, E. Radicioni, N.F. Calabria, L.N. Machado, G. De Rosa, G. Collazuol, F. Iacob, M. Lamoureux, M. Mattiazzi, N. Ospina, L. Ludovici, Y. Maekawa, Y. Nishimura, M. Friend, T. Hasegawa, T. Ishida, T. Kobayashi, M. Jakkapu, T. Matsubara, T. Nakadaira, K. Nakamura, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, T. Boschi, J. Gao, F. Di Lodovico, J. Migenda, M. Taani, S. Zsoldos, Y. Kotsar, Y. Nakano, H. Ozaki, T. Shiozawa, A.T. Suzuki, Y. Takeuchi, S. Yamamoto, A. Ali, Y. Ashida, J. Feng, S. Hirota, T. Kikawa, M. Mori, T. Nakaya, R.A. Wendell, K. Yasutome, P. Fernandez, N. McCauley, P. Mehta, K.M. Tsui, Y. Fukuda, Y. Itow, H. Menjo, T. Niwa, K. Sato, M. Tsukada, J. Lagoda, S.M. Lakshmi, P. Mijakowski, J. Zalipska, J. Jiang, C.K. Jung, C. Vilela, M.J. Wilking, C. Yanagisawa, K. Hagiwara, M. Harada, T. Horai, H. Ishino, S. Ito, F. Kitagawa, Y. Koshio, W. Ma, N. Piplani, S. Sakai, G. Barr, D. Barrow, L. Cook, A. Goldsack, S. Samani, D. Wark, F. Nova, J.Y. Yang, S.J. Jenkins, M. Malek, J.M. McElwee, O. Stone, M.D. Thiesse, L.F. Thompson, H. Okazawa, S.B. Kim, J.W. Seo, I. Yu, A.K. Ichikawa, K. Nishijima, M. Koshiba, K. Iwamoto, Y. Nakajima, N. Ogawa, M. Yokoyama, K. Martens, M.R. Vagins, M. Kuze, S. Izumiyama, T. Yoshida, M. Inomoto, M. Ishitsuka, H. Ito, T. Kinoshita, R. Matsumoto, K. Ohta, M. Shinoki, T. Suganuma, J.F. Martin, H.A. Tanaka, T. Towstego, R. Akutsu, M. Hartz, A. Konaka, P. de Perio, N.W. Prouse, S. Chen, B.D. Xu, M. Posiadala-Zezula, D. Hadley, M. O’Flaherty, B. Richards, B. Jamieson, J. Walker, A. Minamino, G. Pintaudi, S. Sano, R. Sasaki, Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Ikeda, M., Imaizumi, S., Kameda, J., Kanemura, Y., Kataoka, Y., Miki, S., Miura, M., Moriyama, S., Nagao, Y., Nakahata, M., Nakayama, S., Okada, T., Okamoto, K., Orii, A., Pronost, G., Sekiya, H., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Xia, J., Megias, G. D., Bravo-Berguno, D., Labarga, L., Marti, L., Zaldivar, B., Pointon, B. W., Blaszczyk, F. D. M., Kearns, E., Raaf, J. L., Stone, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Kropp, W. R., Locke, S., Mine, S., Smy, M. B., Sobel, H. W., Takhistov, V., Hill, J., Kim, J. Y., Lim, I. T., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Bernard, L., Coffani, A., Drapier, O., Hedri, S. E., Giampaolo, A., Gonin, M., Mueller, T. A., Paganini, P., Quilain, B., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Anthony, L. H. V., Martin, D., Scott, M., Sztuc, A. A., Uchida, Y., Cao, S., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Nascimento Machado, L., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ospina, N., Ludovici, L., Maekawa, Y., Nishimura, Y., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Boschi, T., Gao, J., Di Lodovico, F., Migenda, J., Taani, M., Zsoldos, S., Kotsar, Y., Nakano, Y., Ozaki, H., Shiozawa, T., Suzuki, A. T., Takeuchi, Y., Yamamoto, S., Ali, A., Ashida, Y., Feng, J., Hirota, S., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Fernandez, P., Mccauley, N., Mehta, P., Tsui, K. M., Fukuda, Y., Itow, Y., Menjo, H., Niwa, T., Sato, K., Tsukada, M., Lagoda, J., Lakshmi, S. M., Mijakowski, P., Zalipska, J., Jiang, J., Jung, C. K., Vilela, C., Wilking, M. J., Yanagisawa, C., Hagiwara, K., Harada, M., Horai, T., Ishino, H., Ito, S., Kitagawa, F., Koshio, Y., Ma, W., Piplani, N., Sakai, S., Barr, G., Barrow, D., Cook, L., Goldsack, A., Samani, S., Wark, D., Nova, F., Yang, J. Y., Jenkins, S. J., Malek, M., Mcelwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Okazawa, H., Kim, S. B., Seo, J. W., Yu, I., Ichikawa, A. K., Nishijima, K., Koshiba, M., Iwamoto, K., Nakajima, Y., Ogawa, N., Yokoyama, M., Martens, K., Vagins, M. R., Kuze, M., Izumiyama, S., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Kinoshita, T., Matsumoto, R., Ohta, K., Shinoki, M., Suganuma, T., Martin, J. F., Tanaka, H. A., Towstego, T., Akutsu, R., Hartz, M., Konaka, A., de Perio, P., Prouse, N. W., Chen, S., Xu, B. D., Posiadala-Zezula, M., Hadley, D., O'Flaherty, M., Richards, B., Jamieson, B., Walker, J., Minamino, A., Pintaudi, G., Sano, S., and Sasaki, R.
Subjects: Nuclear and High Energy Physics, Gadolinium Neutrino Neutron Water Cherenkov detector, Physics - Instrumentation and Detectors, 010308 nuclear & particles physics, FOS: Physical sciences, Gadolinium, Neutron, Instrumentation and Detectors (physics.ins-det), 01 natural sciences, Water Cherenkov detector, 0103 physical sciences, Neutrino, 010306 general physics, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract: In order to improve Super-Kamiokande's neutron detection efficiency and to thereby increase its sensitivity to the diffuse supernova neutrino background flux, 13 tons of $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$ (gadolinium sulfate octahydrate) was dissolved into the detector's otherwise ultrapure water from July 14 to August 17, 2020, marking the start of the SK-Gd phase of operations. During the loading, water was continuously recirculated at a rate of 60 m$^3$/h, extracting water from the top of the detector and mixing it with concentrated $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$ solution to create a 0.02% solution of the Gd compound before injecting it into the bottom of the detector. A clear boundary between the Gd-loaded and pure water was maintained through the loading, enabling monitoring of the loading itself and the spatial uniformity of the Gd concentration over the 35 days it took to reach the top of the detector. During the subsequent commissioning the recirculation rate was increased to 120 m$^3$/h, resulting in a constant and uniform distribution of Gd throughout the detector and water transparency equivalent to that of previous pure-water operation periods. Using an Am-Be neutron calibration source the mean neutron capture time was measured to be $115\pm1$ $\mu$s, which corresponds to a Gd concentration of $111\pm2$ ppm, as expected for this level of Gd loading. This paper describes changes made to the water circulation system for this detector upgrade, the Gd loading procedure, detector commissioning, and the first neutron calibration measurements in SK-Gd., Comment: 37 pages, 19 Figures, Accepted for publication in Nucl. Instrum. Meth. A
Published: 2022

8. Neutron tagging following atmospheric neutrino events in a water Cherenkov detector

Author: K. Abe, Y. Haga, Y. Hayato, K. Hiraide, K. Ieki, M. Ikeda, S. Imaizumi, K. Iyogi, J. Kameda, Y. Kanemura, Y. Kataoka, Y. Kato, Y. Kishimoto, S. Miki, S. Mine, M. Miura, T. Mochizuki, S. Moriyama, Y. Nagao, M. Nakahata, T. Nakajima, Y. Nakano, S. Nakayama, T. Okada, K. Okamoto, A. Orii, K. Sato, H. Sekiya, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, A. Takenaka, H. Tanaka, S. Tasaka, T. Tomura, K. Ueno, S. Watanabe, T. Yano, T. Yokozawa, S. Han, T. Irvine, T. Kajita, I. Kametani, K. Kaneyuki, K.P. Lee, T. McLachlan, K. Okumura, E. Richard, T. Tashiro, R. Wang, J. Xia, G.D. Megias, D. Bravo-Berguño, L. Labarga, B. Zaldivar, M. Goldhaber, F.d.M. Blaszczyk, J. Gustafson, C. Kachulis, E. Kearns, J.L. Raaf, J.L. Stone, L.R. Sulak, S. Sussman, L. Wan, T. Wester, B.W. Pointon, J. Bian, G. Carminati, M. Elnimr, N.J. Griskevich, W.R. Kropp, S. Locke, A. Renshaw, M.B. Smy, H.W. Sobel, V. Takhistov, P. Weatherly, K.S. Ganezer, B.L. Hartfiel, J. Hill, W.E. Keig, N. Hong, J.Y. Kim, I.T. Lim, R.G. Park, T. Akiri, B. Bodur, A. Himmel, Z. Li, E. O'Sullivan, K. Scholberg, C.W. Walter, T. Wongjirad, L. Bernard, A. Coffani, O. Drapier, S. El Hedri, A. Giampaolo, J. Imber, Th.A. Mueller, P. Paganini, B. Quilain, T. Ishizuka, T. Nakamura, J.S. Jang, K. Choi, J.G. Learned, S. Matsuno, S.N. Smith, J. Amey, L.H.V. Anthony, R.P. Litchfield, W.Y. Ma, D. Marin, A.A. Sztuc, Y. Uchida, M.O. Wascko, V. Berardi, M.G. Catanesi, R.A. Intonti, E. Radicioni, N.F. Calabria, G. De Rosa, L.N. Machado, G. Collazuol, F. Iacob, M. Lamoureux, N. Ospina, L. Ludovici, M. Gonin, G. Pronost, Y. Maekawa, Y. Nishimura, S. Cao, M. Friend, T. Hasegawa, T. Ishida, T. Ishii, M. Jakkapu, T. Kobayashi, T. Matsubara, T. Nakadaira, K. Nakamura, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, T. Boschi, F. Di Lodovico, J. Migenda, S. Molina Sedgwick, M. Taani, S. Zsoldos, K.E. Abe, M. Hasegawa, Y. Isobe, Y. Kotsar, H. Miyabe, H. Ozaki, T. Shiozawa, T. Sugimoto, A.T. Suzuki, Y. Takeuchi, S. Yamamoto, A. Ali, Y. Ashida, C. Bronner, J. Feng, T. Hayashino, T. Hiraki, S. Hirota, K. Huang, M. Jiang, T. Kikawa, M. Mori, A. Murakami, KE. Nakamura, T. Nakaya, N.D. Patel, K. Suzuki, S. Takahashi, K. Tateishi, R.A. Wendell, K. Yasutome, P. Fernandez, N. McCauley, P. Mehta, A. Pritchard, K.M. Tsui, Y. Fukuda, Y. Itow, H. Menjo, G. Mitsuka, M. Murase, F. Muto, T. Niwa, T. Suzuki, M. Tsukada, K. Frankiewicz, P. Mijakowski, J. Hignight, J. Jiang, C.K. Jung, X. Li, J.L. Palomino, G. Santucci, C. Vilela, M.J. Wilking, C. Yanagisawa, D. Fukuda, K. Hagiwara, M. Harada, T. Horai, H. Ishino, S. Ito, T. Kayano, A. Kibayashi, H. Kitagawa, Y. Koshio, W. Ma, T. Mori, H. Nagata, N. Piplani, S. Sakai, M. Sakuda, Y. Takahira, C. Xu, R. Yamaguchi, Y. Kuno, G. Barr, D. Barrow, L. Cook, A. Goldsack, S. Samani, C. Simpson, D. Wark, F. Nova, R. Tacik, J.Y. Yang, A. Cole, S.J. Jenkins, M. Malek, J.M. McElwee, O. Stone, M.D. Thiesse, L.F. Thompson, H. Okazawa, Y. Choi, S.B. Kim, I. Yu, A.K. Ichikawa, K. Ito, K. Nishijima, R.G. Calland, P. de Perio, K. Martens, M. Murdoch, M.R. Vagins, M. Koshiba, Y. Totsuka, K. Iwamoto, Y. Nakajima, N. Ogawa, Y. Suda, M. Yokoyama, D. Hamabe, S. Izumiyama, M. Kuze, Y. Okajima, M. Tanaka, T. Yoshida, M. Inomoto, M. Ishitsuka, H. Ito, R. Matsumoto, K. Ohta, M. Shinoki, J.F. Martin, C.M. Nantais, H.A. Tanaka, T. Towstego, R. Akutsu, M. Hartz, A. Konaka, N.W. Prouse, S. Chen, B.D. Xu, Y. Zhang, S. Berkman, S. Tobayama, K. Connolly, R.J. Wilkes, M. Posiadala-Zezula, D. Hadley, B. Richards, B. Jamieson, J. Walker, Ll. Marti, A. Minamino, G. Pintaudi, S. Sano, R. Sasaki, Abe, K., Haga, Y., Hayato, Y., Hiraide, K., Ieki, K., Ikeda, M., Imaizumi, S., Iyogi, K., Kameda, J., Kanemura, Y., Kataoka, Y., Kato, Y., Kishimoto, Y., Miki, S., Mine, S., Miura, M., Mochizuki, T., Moriyama, S., Nagao, Y., Nakahata, M., Nakajima, T., Nakano, Y., Nakayama, S., Okada, T., Okamoto, K., Orii, A., Sato, K., Sekiya, H., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Tasaka, S., Tomura, T., Ueno, K., Watanabe, S., Yano, T., Yokozawa, T., Han, S., Irvine, T., Kajita, T., Kametani, I., Kaneyuki, K., Lee, K. P., Mclachlan, T., Okumura, K., Richard, E., Tashiro, T., Wang, R., Xia, J., Megias, G. D., Bravo-Bergu??o, D., Labarga, L., Zaldivar, B., Goldhaber, M., Blaszczyk, F. d. M., Gustafson, J., Kachulis, C., Kearns, E., Raaf, J. L., Stone, J. L., Sulak, L. R., Sussman, S., Wan, L., Wester, T., Pointon, B. W., Bian, J., Carminati, G., Elnimr, M., Griskevich, N. J., Kropp, W. R., Locke, S., Renshaw, A., Smy, M. B., Sobel, H. W., Takhistov, V., Weatherly, P., Ganezer, K. S., Hartfiel, B. L., Hill, J., Keig, W. E., Hong, N., Kim, J. Y., Lim, I. T., Park, R. G., Akiri, T., Bodur, B., Himmel, A., Li, Z., O'Sullivan, E., Scholberg, K., Walter, C. W., Wongjirad, T., Bernard, L., Coffani, A., Drapier, O., El Hedri, S., Giampaolo, A., Imber, J., Mueller, Th. A., Paganini, P., Quilain, B., Ishizuka, T., Nakamura, T., Jang, J. S., Choi, K., Learned, J. G., Matsuno, S., Smith, S. N., Amey, J., Anthony, L. H. V., Litchfield, R. P., Ma, W. Y., Marin, D., Sztuc, A. A., Uchida, Y., Wascko, M. O., Berardi, V., Catanesi, M. G., Intonti, R. A., Radicioni, E., Calabria, N. F., De Rosa, G., Nascimento Machado, L., Collazuol, G., Iacob, F., Lamoureux, M., Ospina, N., Ludovici, L., Gonin, M., Pronost, G., Maekawa, Y., Nishimura, Y., Cao, S., Friend, M., Hasegawa, T., Ishida, T., Ishii, T., Jakkapu, M., Kobayashi, T., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Boschi, T., Di Lodovico, F., Migenda, J., Molina Sedgwick, S., Taani, M., Zsoldos, S., Abe, K. E., Hasegawa, M., Isobe, Y., Kotsar, Y., Miyabe, H., Ozaki, H., Shiozawa, T., Sugimoto, T., Suzuki, A. T., Takeuchi, Y., Yamamoto, S., Ali, A., Ashida, Y., Bronner, C., Feng, J., Hayashino, T., Hiraki, T., Hirota, S., Huang, K., Jiang, M., Kikawa, T., Mori, M., Murakami, A., Nakamura, Ke., Nakaya, T., Patel, N. D., Suzuki, K., Takahashi, S., Tateishi, K., Wendell, R. A., Yasutome, K., Fernandez, P., Mccauley, N., Mehta, P., Pritchard, A., Tsui, K. M., Fukuda, Y., Itow, Y., Menjo, H., Mitsuka, G., Murase, M., Muto, F., Niwa, T., Suzuki, T., Tsukada, M., Frankiewicz, K., Mijakowski, P., Hignight, J., Jiang, J., Jung, C. K., Li, X., Palomino, J. L., Santucci, G., Vilela, C., Wilking, M. J., Yanagisawa, C., Fukuda, D., Hagiwara, K., Harada, M., Horai, T., Ishino, H., Ito, S., Kayano, T., Kibayashi, A., Kitagawa, H., Koshio, Y., Ma, W., Mori, T., Nagata, H., Piplani, N., Sakai, S., Sakuda, M., Takahira, Y., Xu, C., Yamaguchi, R., Kuno, Y., Barr, G., Barrow, D., Cook, L., Goldsack, A., Samani, S., Simpson, C., Wark, D., Nova, F., Tacik, R., Yang, J. Y., Cole, A., Jenkins, S. J., Malek, M., Mcelwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Okazawa, H., Choi, Y., Kim, S. B., Yu, I., Ichikawa, A. K., Ito, K., Nishijima, K., Calland, R. G., de Perio, P., Martens, K., Murdoch, M., Vagins, M. R., Koshiba, M., Totsuka, Y., Iwamoto, K., Nakajima, Y., Ogawa, N., Suda, Y., Yokoyama, M., Hamabe, D., Izumiyama, S., Kuze, M., Okajima, Y., Tanaka, M., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Matsumoto, R., Ohta, K., Shinoki, M., Martin, J. F., Nantais, C. M., Tanaka, H. A., Towstego, T., Akutsu, R., Hartz, M., Konaka, A., Prouse, N. W., Chen, S., Xu, B. D., Zhang, Y., Berkman, S., Tobayama, S., Connolly, K., Wilkes, R. J., Posiadala-Zezula, M., Hadley, D., Richards, B., Jamieson, B., Walker, J., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., and Sasaki, R.
Subjects: Physics - Instrumentation and Detectors, Large detector systems for particle and astroparticle physics, hep-ex, Cherenkov detectors, FOS: Physical sciences, Acceleratorfysik och instrumentering, Instrumentation and Detectors (physics.ins-det), Accelerator Physics and Instrumentation, High Energy Physics - Experiment, Subatomär fysik, High Energy Physics - Experiment (hep-ex), Particle identification methods, Neutrino detectors, Subatomic Physics, Cherenkov detectors Large detector systems for particle and astroparticle physics Neutrino detectors Particle identification methods, Detectors and Experimental Techniques, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), physics.ins-det, Mathematical Physics, Particle Physics - Experiment, astro-ph.IM
Abstract: We present the development of neutron-tagging techniques in Super-Kamiokande IV using a neural network analysis. The detection efficiency of neutron capture on hydrogen is estimated to be 26%, with a mis-tag rate of 0.016 per neutrino event. The uncertainty of the tagging efficiency is estimated to be 9.0%. Measurement of the tagging efficiency with data from an Americium-Beryllium calibration agrees with this value within 10%. The tagging procedure was performed on 3,244.4 days of SK-IV atmospheric neutrino data, identifying 18,091 neutrons in 26,473 neutrino events. The fitted neutron capture lifetime was measured as 218±9 μs. We present the development of neutron-tagging techniques in Super-Kamiokande IV using a neural network analysis. The detection efficiency of neutron capture on hydrogen is estimated to be 26%, with a mis-tag rate of 0.016 per neutrino event. The uncertainty of the tagging efficiency is estimated to be 9.0%. Measurement of the tagging efficiency with data from an Americium-Beryllium calibration agrees with this value within 10%. The tagging procedure was performed on 3,244.4 days of SK-IV atmospheric neutrino data, identifying 18,091 neutrons in 26,473 neutrino events. The fitted neutron capture lifetime was measured as 218 \pm 9 \mu s.
Published: 2022

9. Search for neutrinos in coincidence with gravitational wave events from the LIGO–Virgo O3a observing run with the Super-Kamiokande detector

Author: Y. Kanemura, A. Giampaolo, W. R. Kropp, Y. Hayato, A. A. Sztuc, P. Mehta, Pablo Fernandez, T. Hasegawa, F. Iacob, D. Bravo-Berguño, Y. Kuno, T. Towstego, O. Drapier, H. Ito, Sei-ichiro Watanabe, G.D. Barr, J. Bian, N. Piplani, S. Miki, S. V. Cao, M. R. Vagins, K. Martens, Y. Takemoto, L. F. Thompson, S. Imaizumi, A. Coffani, O. Stone, J. S. Jang, M. Taani, Seiko Hirota, T. Kikawa, M. Gonin, J. Xia, Masahiro Kuze, A. Goldsack, S. Han, M. J. Wilking, R. A. Wendell, M. B. Smy, Junjie Jiang, F. Nova, E. Radicioni, Kimihiro Okumura, B. Zaldivar, J. Y. Kim, S. Izumiyama, A. Orii, S. Mine, L. Cook, J. Migenda, John Hill, A. T. Suzuki, K. Okamoto, T. Horai, R. Sasaki, J. F. Martin, J. Kameda, B. Bodur, Yuichi Oyama, T. Nakadaira, J. McElwee, J. L. Stone, I. T. Lim, F. Di Lodovico, D. L. Wark, Vincenzo Berardi, Y. Maekawa, S. El Hedri, T. Sekiguchi, L. Ludovici, Th. A. Mueller, N. Ospina, K. Ohta, G. De Rosa, Hiromasa Tanaka, V. Takhistov, Hiroaki Menjo, C. Simpson, J. G. Learned, K. M. Tsui, P. Mijakowski, J. Y. Yang, K. Abe, J. L. Raaf, M. Tsukada, M. Thiesse, K. Iwamoto, H. K. Tanaka, Yasunari Suzuki, S. Samani, G. D. Megias, A. Konaka, M. G. Catanesi, N. J. Griskevich, Y. Nishimura, David Hadley, F. d. M. Blaszczyk, M. Inomoto, S. Locke, Masaki Ishitsuka, M. Jakkapu, Yusuke Koshio, S. Sakai, D. Barrow, M. Lamoureux, P. Weatherly, P. de Perio, T. Boschi, T. Niwa, K. Nakamura, T. Yoshida, A. Pritchard, C. K. Jung, R. Matsumoto, M. Hartz, T. Shiozawa, C. Vilela, Ahmed Ali, M. Koshiba, Masato Shiozawa, H. Ozaki, T. Tashiro, S. Moriyama, S. Nakayama, R. Akutsu, L. H. V. Anthony, Hussain Kitagawa, S. J. Jenkins, B. Jamieson, R. G. Park, Song Chen, P. Paganini, M. Miura, Masayuki Nakahata, H. W. Sobel, Yuuki Nakano, Y. Uchida, B. D. Xu, Ll. Marti, Kate Scholberg, K. Hagiwara, Yutaka Nakajima, B. W. Pointon, D. Martin, Manabu Tanaka, K. Sato, G. Pintaudi, H. Okazawa, M. Ikeda, L. Wan, S. Molina Sedgwick, Hirokazu Ishino, Y. Kotsar, N. F. Calabria, Yuto Ashida, C. Yanagisawa, E. Kearns, C. Bronner, Masashi Yokoyama, Intae Yu, K. Yasutome, T. Nakamura, G. Collazuol, J. Walker, L. N. Machado, N. Ogawa, K. Nishijima, T. Wester, L. Bernard, T. Ishizuka, M. Harada, Tsuyoshi Nakaya, Y. Nagao, Atsushi Takeda, A. Minamino, Rongkun Wang, S. B. Kim, M. Shinoki, A. K. Ichikawa, N. McCauley, L. Labarga, T. Kobayashi, M. Malek, N. W. Prouse, B. Richards, T. Matsubara, S. Yamamoto, C. W. Walter, K. Sakashita, J. Feng, M. Posiadala-Zezula, W. Ma, B. Quilain, Hiroyuki Sekiya, Y. Kataoka, Y. Fukuda, Y. Takeuchi, T. Kajita, Takatomi Yano, M. Friend, M. Mori, Y. Sonoda, S. Sano, Yoshitaka Itow, G. Pronost, Shintaro Ito, S. Zsoldos, T. Tsukamoto, T. Okada, T. Ishida, A. Takenaka, UAM. Departamento de Física Teórica, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Super-Kamiokande, Abe, K., Bronner, C., Hayato, Y., Ikeda, M., Imaizumi, S., Kameda, J., Kanemura, Y., Kataoka, Y., Miki, S., Miura, M., Moriyama, S., Nagao, Y., Nakahata, M., Nakayama, S., Okada, T., Okamoto, K., Orii, A., Pronost, G., Sekiya, H., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Wang, R., Xia, J., Megias, G. D., Bravo-Berguno, D., Labarga, L., Marti, Ll., Zaldivar, B., Pointon, B. W., Blaszczyk, F. D. M., Kearns, E., Raaf, J. L., Stone, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Kropp, W. R., Locke, S., Mine, S., Smy, M. B., Sobel, H. W., Takhistov, V., Weatherly, P., Hill, J., Kim, J. Y., Lim, I. T., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Bernard, L., Coffani, A., Drapier, O., El Hedri, S., Giampaolo, A., Gonin, M., Mueller, Th. A., Paganini, P., Quilain, B., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Anthony, L. H. V., Martin, D. G. R., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Nascimento Machado, L., de Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Ospina, N., Ludovici, L., Maekawa, Y., Nishimura, Y., Cao, S., Friend, M., Hasegawa, T., Ishida, T., Jakkapu, M., Kobayashi, T., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Kotsar, Y., Nakano, Y., Ozaki, H., Shiozawa, T., Suzuki, A. T., Takeuchi, Y., Yamamoto, S., Ali, A., Ashida, Y., Feng, J., Hirota, S., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Fernandez, P., Mccauley, N., Mehta, P., Pritchard, A., Tsui, K. M., Fukuda, Y., Itow, Y., Menjo, H., Niwa, T., Sato, K., Tsukada, M., Mijakowski, P., Jiang, J., Jung, C. K., Vilela, C., Wilking, M. J., Yanagisawa, C., Hagiwara, K., Harada, M., Horai, T., Ishino, H., Ito, S., Koshio, Y., Kitagawa, H., Ma, W., Piplani, N., Sakai, S., Kuno, Y., Barr, G., Barrow, D., Cook, L., Goldsack, A., Samani, S., Simpson, C., Wark, D., Nova, F., Boschi, T., Di Lodovico, F., Migenda, J., Molina Sedgwick, S., Taani, M., Zsoldos, S., Yang, J. Y., Jenkins, S. J., Malek, M., Mcelwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Okazawa, H., Kim, S. B., Yu, I., Nishijima, K., Koshiba, M., Iwamoto, K., Nakajima, Y., Ogawa, N., Yokoyama, M., Martens, K., Vagins, M. R., Izumiyama, S., Kuze, M., Tanaka, M., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Matsumoto, R., Ohta, K., Shinoki, M., Martin, J. F., Tanaka, H. A., Towstego, T., Akutsu, R., Hartz, M., Konaka, A., de Perio, P., Prouse, N. W., Chen, S., Xu, B. D., Posiadala-Zezula, M., Hadley, D., Richards, B., Jamieson, B., Walker, J., Minamino, A., Pintaudi, G., Sano, S., Sasaki, R., and Ichikawa, A. K.
Subjects: Astrophysics, KAMIOKANDE, Neutrino Astronomy, GeV, 01 natural sciences, 7. Clean energy, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Neutrino astronomy Gravitational wave astronomy High energy astrophysics Black holes Compact objects Neutron stars Transient sources, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], LIGO, 010303 astronomy & astrophysics, QC, QB, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), energy: emission, Black holes, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, High energy astrophysics, High-energy astronomy, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Gravitational-wave astronomy, Neutron stars, neutrino: spectrum, 0103 physical sciences, Instrumentation and Methods for Astrophysics (astro-ph.IM), Compact objects, flavor, 010308 nuclear & particles physics, Gravitational wave, background, gravitational radiation, Física, Astronomy and Astrophysics, trigger, Transient sources, flux, Neutron star, VIRGO, Space and Planetary Science, High Energy Physics::Experiment, Gravitational wave astronomy, Neutrino astronomy, Super-Kamiokande, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], statistical
Abstract: The Super-Kamiokande detector can be used to search for neutrinos in time coincidence with gravitational waves detected by the LIGO-Virgo Collaboration (LVC). Both low-energy ($7-100$ MeV) and high-energy ($0.1-10^5$ GeV) samples were analyzed in order to cover a very wide neutrino spectrum. Follow-ups of 36 (out of 39) gravitational waves reported in the GWTC-2 catalog were examined; no significant excess above the background was observed, with 10 (24) observed neutrinos compared with 4.8 (25.0) expected events in the high-energy (low-energy) samples. A statistical approach was used to compute the significance of potential coincidences. For each observation, p-values were estimated using neutrino direction and LVC sky map ; the most significant event (GW190602_175927) is associated with a post-trial p-value of $7.8\%$ ($1.4\sigma$). Additionally, flux limits were computed independently for each sample and by combining the samples. The energy emitted as neutrinos by the identified gravitational wave sources was constrained, both for given flavors and for all-flavors assuming equipartition between the different flavors, independently for each trigger and by combining sources of the same nature., Comment: 16 pages, 5 figures. v2: adding corrections from The Astrophysical Journal review
Published: 2021

10. Diffuse Supernova Neutrino Background search at Super-Kamiokande with neutron tagging

Author: K. Sakashita, A. T. Suzuki, K. Okamoto, M. Posiadala-Zezula, T. Nakadaira, Takuto Suganuma, David Wark, Y. Kataoka, Y. Takeuchi, S. Sakai, Y. Nishimura, Shintaro Ito, Atsushi Takeda, G.D. Barr, B. Quilain, E. Kearns, T. Yano, Tatsuya Kikawa, L. Marti, Yasuhiro Nakajima, Masashi Yokoyama, Tatsushi Kinoshita, Joanna Zalipska, Y. Nagao, A. Minamino, Henry W. Sobel, Marco Mattiazzi, J. McElwee, J. Y. Kim, M. Shinoki, Kenzo Nakamura, M. Friend, N. W. Prouse, Yoshihiro Suzuki, H. A. Tanaka, C. W. Walter, A. Coffani, T. Ishizuka, N. McCauley, Tsuyoshi Nakaya, O. Stone, M. Malek, S. Miki, Takashi Kobayashi, David Hadley, T. Hasegawa, C. K. Jung, S. Yamamoto, Makoto Miura, Yuichi Oyama, O. Drapier, M. Ikeda, Masato Shiozawa, L. Ludovici, A. Takenaka, Hiroyuki Sekiya, S. Izumiyama, T. Matsubara, N. Piplani, Soo-Bong Kim, J. Y. Yang, Y. Fukuda, L. Wan, A. Ali, J. Feng, T. Tsukamoto, S. Locke, S. Mohan Lakshmi, A. Konaka, Hiroaki Menjo, M. Koshiba, Masahiro Kuze, F. Nova, M. Hartz, Takaaki Kajita, R. G. Park, Yuuki Nakano, Yusuke Koshio, R. Sasaki, D. Barrow, Thomas A. Mueller, T. Ishida, B. W. Pointon, Natalv Ospina, Kate Scholberg, K. Yasutome, John Fraser Martin, James Hill, T. Tashiro, Hirokazu Ishino, S. J. Jenkins, E. Radicioni, Marcus O'Flaherty, T. Nakamura, R. Matsumoto, G. Collazuol, Intae Yu, Mark Scott, N. Ogawa, J. L. Raaf, C. Yanagisawa, Yoshinari Hayato, L. Bernard, K. Martens, M. Jakkapu, S. Mine, K. M. Tsui, A. Goldsack, S. Nakayama, M. Taani, T. Boschi, R. A. Wendell, M. Mori, M. Lamoureux, Y. Sonoda, Hiroshi Ito, S. Sano, K. Nishijima, Yoshitaka Itow, T. Wester, S. Han, G. Pronost, H. Okazawa, M. J. Wilking, D. Martin, K. Sato, A. K. Ichikawa, J. Kameda, F. Iacob, P. Mijakowski, K. Abe, Shuhei Watanabe, B. Bodur, Y. Kanemura, A. Giampaolo, Pablo Fernandez, P. Mehta, T. Towstego, S. Zsoldos, Vincenzo Berardi, S. Cao, William R. Kropp, T. Sekiguchi, S. Chen, G. D. Megias, J. Bian, M. Gonin, J. Xia, Sonia El Hedri, M. Thiesse, K. Iwamoto, C. Bronner, Gianfranca De Rosa, J. S. Jang, H. Ozaki, Hussain Kitagawa, B. Jamieson, Patrick de Perio, Katsuki Hiraide, K. Nakamura, Y. Maekawa, Jeff N. Griskevich, S. Moriyama, G. Pintaudi, Masayuki Nakahata, Y. Uchida, N. F. Calabria, J. G. Learned, H. K. Tanaka, P. Paganini, B. D. Xu, S. Samani, M. G. Catanesi, Lester D.R. Thompson, M. R. Vagins, Y. Kotsar, John Walker, L. Cook, I. T. Lim, L. H. V. Anthony, R. Akutsu, C. Vilela, FD Lodovico, Junjie Jiang, V. Takhistov, Justyna Lagoda, Jingyuan Gao, W. Ma, L. Labarga, B. Richards, Kimihiro Okumura, Yasuhiro Takemoto, Masaki Ishitsuka, M. Inomoto, A. A. Sztuc, M. B. Smy, B. Zaldivar, J. Migenda, L. N. Machado, and M. Harada
Subjects: Physics, Supernova, Neutron, Astrophysics, Neutrino, Super-Kamiokande
Published: 2021

11. Low energy radioactivity BG model in Super-Kamiokande detector from SK-IV data

Author: S. J. Jenkins, K. Nakamura, M. R. Vagins, M. Taani, J. L. Raaf, John Walker, H. Okazawa, Masaki Ishitsuka, S. Moriyama, A. A. Sztuc, P. Mehta, S. Miki, Masayuki Nakahata, Y. Uchida, I. T. Lim, L. H. V. Anthony, Junjie Jiang, V. Takhistov, Yoshinari Hayato, T. Towstego, M. Jakkapu, J. Y. Kim, Y. Maekawa, Patrick de Perio, Atsushi Takeda, T. Boschi, Yasuhiro Nakajima, J. G. Learned, Shuhei Watanabe, A. K. Ichikawa, T. Yano, Hiroshi Ito, A. T. Suzuki, K. Okamoto, Vincenzo Berardi, J. Kameda, S. Izumiyama, Joanna Zalipska, H. K. Tanaka, L. Cook, A. Coffani, S. Samani, M. G. Catanesi, O. Drapier, M. B. Smy, B. Zaldivar, Y. Takeuchi, J. Migenda, O. Stone, B. Bodur, T. Nakadaira, Takashi Kobayashi, P. Mijakowski, S. Zsoldos, Sonia El Hedri, T. Hasegawa, A. Ali, Katsuki Hiraide, Makoto Miura, K. Nishijima, M. Thiesse, K. Iwamoto, Justyna Lagoda, T. Wester, F. Iacob, Jingyuan Gao, Y. Nagao, A. Minamino, S. Mohan Lakshmi, Lester D.R. Thompson, M. Hartz, L. N. Machado, Kenzo Nakamura, K. Sakashita, W. Ma, T. Matsubara, William R. Kropp, T. Sekiguchi, S. Chen, M. Shinoki, M. Harada, N. McCauley, S. Sakai, M. Posiadala-Zezula, R. Akutsu, Marco Mattiazzi, J. Feng, M. Friend, Yuuki Nakano, K. Abe, Shintaro Ito, M. Malek, N. Piplani, B. W. Pointon, S. Yamamoto, Y. Kanemura, A. Giampaolo, Kate Scholberg, Hiroaki Menjo, N. W. Prouse, C. W. Walter, E. Kearns, David Wark, P. Paganini, Kimihiro Okumura, Takaaki Kajita, C. Vilela, T. Tashiro, FD Lodovico, M. Koshiba, B. D. Xu, Masashi Yokoyama, G.D. Barr, Yasuhiro Takemoto, T. Nakamura, S. Locke, Y. Kataoka, James Hill, M. Inomoto, Intae Yu, R. G. Park, Tatsuya Kikawa, G. D. Megias, Pablo Fernandez, R. Matsumoto, L. Marti, N. Ogawa, G. Pintaudi, David Hadley, Hiroyuki Sekiya, J. S. Jang, Hirokazu Ishino, N. Jeff Griskevich, L. Labarga, Soo-Bong Kim, S. Han, L. Bernard, T. Ishizuka, C. Yanagisawa, Tsuyoshi Nakaya, Y. Fukuda, L. Wan, B. Richards, T. Tsukamoto, K. Yasutome, Marcus O'Flaherty, C. K. Jung, Yuichi Oyama, M. Ikeda, A. Goldsack, N. F. Calabria, S. Nakayama, G. Collazuol, Mark Scott, Masato Shiozawa, R. A. Wendell, L. Ludovici, J. Y. Yang, T. Ishida, K. Martens, S. Mine, K. M. Tsui, Y. Kotsar, Y. Nishimura, Masahiro Kuze, F. Nova, R. Sasaki, A. Konaka, M. Lamoureux, Yusuke Koshio, D. Martin, J. Bian, H. Ozaki, Hussain Kitagawa, B. Jamieson, Natalv Ospina, S. Cao, D. Barrow, John Fraser Martin, A. Takenaka, K. Sato, C. Bronner, M. Gonin, J. Xia, Gianfranca De Rosa, Tatsushi Kinoshita, Yoshihiro Suzuki, Henry W. Sobel, J. McElwee, H. A. Tanaka, E. Radicioni, B. Quilain, M. Mori, Y. Sonoda, S. Sano, Yoshitaka Itow, Takuto Suganuma, G. Pronost, M. J. Wilking, Thomas A. Mueller, Pronost, Guillaume, Abe, Ko, Bronner, Christophe, Hayato, Yoshinari, Hiraide, Katsuki, Ikeda, Motoyasu, Kameda, Jun, Kanemura, Yuki, Kataoka, Yousuku, Miki, Shintaro, Miura, Makoto, Moriyama, Shigetaka, Nagao, Yoshiki, Nakahata, Masayuki, Nakayama, Shoei, Okamoto, Kohei, Sekiya, Hiroyuki, Shiozawa, Masato, Sonoda, Yutaro, Suzuki, Yoichiro, Takeda, Atsushi, Takemoto, Yasuhiro, Takenaka, Akira, Tanaka, Hidekazu, Watanabe, Shuhei, Yano, Takatomi, Han, Seungho, Kajita, Takaaki, Okumura, Kimihiro, Tashiro, Takuya, Xia, Junjie, Megias, Guillermo, Labarga, Lui, Marti, Llui, Zaldivar, Bryan, Pointon, Barry W., Kearns, Edward, Raaf, Jennifer L., Wan, Linyan, Wester, Thoma, Bian, Jianming, Griskevich, N. Jeff, Kropp, William R., Locke, Scott, Mine, Shunichi, Smy, Michael, Sobel, Henry W., Takhistov, Volodymyr, Hill, Jame, Kim, Jae Yool, Lim, In Taek, Park, Ryeong Gyoon, Bodur, Baran, Scholberg, Kate, Walter, Chri, Bernard, Laura, Coffani, Alice, Drapier, Olivier, El Hedri, Sonia, Giampaolo, Alberto, Gonin, Michel, Mueller, Thomas A., Paganini, Pascal, Quilain, Benjamin, Ishizuka, Takeharu, Nakamura, Taku, Jang, Jae Seung, Learned, John G., Cao, Son, Anthony, Lauren H. V., Martin, Daniel, Scott, Mark, Sztuc, Artur A., Uchida, Yoshi, Berardi, Vincenzo, Catanesi, Maria Gabriella, Radicioni, Emilio, Calabria, Nicola F., Machado, Lucas N., De Rosa, Gianfranca, Collazuol, Gianmaria, Iacob, Fabio, Lamoureux, Mathieu, Mattiazzi, Marco, Ospina, Natalv, Ludovici, Lucio, Maekawa, Yuto, Nishimura, Yasuhiro, Friend, Megan, Hasegawa, Takuya, Ishida, Taku, Kobayashi, Takashi, Jakkapu, Mahesh, Matsubara, Tsunayuki, Nakadaira, Takeshi, Nakamura, Kenzo, Oyama, Yuichi, Sakashita, Ken, Sekiguchi, Tetsuro, Tsukamoto, Toshifumi, Boschi, Tommaso, Di Lodovico, Francesca, Gao, Jingyuan, Migenda, Jost, Taani, Mahdi, Zsoldos, Stephane, Nakano, Yuuki, Ozaki, Hironori, Suzuki, Atsumu, Takeuchi, Yasuo, Yamamoto, Shotaro, Kotsar, Yurii, Ali, Ajmi, Feng, Jiahui, Kikawa, Tatsuya, Mori, Masamitsu, Nakaya, Tsuyoshi, Wendell, Roger, Yasutome, Kenji, Fernández, Pablo, Mccauley, Neil, Mehta, Pruthvi, Tsui, Ka Ming, Fukuda, Yoshiyuki, Itow, Yoshitaka, Menjo, Hiroaki, Sato, Kazufumi, Lagoda, Justyna, Lakshmi, S. Mohan, Mijakowski, Piotr, Zalipska, Joanna, Jiang, Junjie, Jung, Chang K., Vilela, Cristovao, Wilking, Michael, Yanagisawa, Chiaki, Harada, Masayuki, Ishino, Hirokazu, Ito, Shintaro, Kitagawa, Hussain, Koshio, Yusuke, Ma, Wenjie, Piplani, Nishtha, Sakai, Seiya, Barr, Gile, Barrow, Danial, Cook, Laurence, Goldsack, Alexander, Samani, Soniya, Wark, David, Nova, Federico, Yang, Jeong Yeol, Jenkins, Sam J., Malek, Matthew, Mcelwee, Jordan, Stone, Owen, Thiesse, Matthew D., Thompson, Lee F., Okazawa, Hiroko, Kim, Soo Bong, Yu, Intae, Ichikawa, Atsuko, Nakamura, Kiseki, Nishijima, Kyoshi, Koshiba, Masatoshi, Iwamoto, Konosuke, Nakajima, Yasuhiro, Ogawa, Natsumi, Yokoyama, Masashi, Martens, Kai, Vagins, Mark, Kuze, Masahiro, Izumiyama, Shota, Inomoto, Michitaka, Ishitsuka, Masaki, Ito, Hiroshi, Kinoshita, Tatsushi, Matsumoto, Ryo, Shinoki, Masataka, Suganuma, Takuto, Martin, John Fraser, Tanaka, Hirohisa, Towstego, Trevor, Akutsu, Ryosuke, de Perio, Patrick, Hartz, Mark, Konaka, Akira, Prouse, Nick, Chen, Shaomin, Xu, Benda D., Posiadala-Zezula, Magdalena, Hadley, David, O'Flaherty, Marcu, Richards, Benjamin, Jamieson, Blair, Walker, John, Minamino, Akihiro, Pintaudi, Ggiorgio, Sano, Shiochi, and Sasaki, Ryota
Subjects: Physics, Physics::Instrumentation and Detectors, Solar neutrino, Physics::Medical Physics, Detector, Water source, chemistry.chemical_element, Radon, Nuclear physics, Low energy, chemistry, High Energy Physics::Experiment, Neutrino, Super-Kamiokande, Solar data
Abstract: The radioactivity background are among the most dangerous background for low energy neutrino analysis in Super-Kamiokande (SK), like the solar neutrino analysis. Among them, the main contribution is coming from $^{222}$Rn, which is spread in the detector's water due to the water source and to the photo multiplier (PMT) emanations. Up to now, its exact distribution in the detector was not known. Using our knowledge of the radon concentration in the detector water, and the SK-IV solar data, we developed a model of the radon distribution in the detector. The uncertainty on the Rn concentration associated with this model was estimated to be $\sim0.1$ mBq/m$^{3}$
Published: 2021

12. Search for tens of MeV neutrinos associated with gamma-ray bursts in Super-Kamiokande

Author: P. Fernandez, Y. Nishimura, M. Inomoto, J. Bian, P. de Perio, G. Pronost, L. Wan, M. Lamoureux, Shintaro Ito, S. Zsoldos, Y. Takeuchi, K. Martens, J. Xia, Y. Sonoda, O. Drapier, Takatomi Yano, S. El Hedri, T. Shiozawa, Ahmed Ali, Ll. Marti, K. Nakamura, C. Xu, Hiroaki Menjo, C. Bronner, A. Konaka, T. Sekiguchi, K. S. Ganezer, M. Hartz, A. Giampaolo, B. Jamieson, N. F. Calabria, J. G. Learned, Takaaki Kajita, K. Yasutome, S. Nakayama, A. Takenaka, M. Harada, Vincenzo Berardi, William R. Kropp, S. Chen, R. G. Park, L. Ludovici, Kimihiro Okumura, Yasuhiro Takemoto, K. M. Tsui, A. Takeda, Hiromasa Tanaka, C. W. Walter, H. Okazawa, K. Okamoto, Y. Ashida, J. McElwee, S. Izumiyama, D. Barrow, Y. Fukuda, M. Ikeda, R. P. Litchfield, T. Okada, Intae Yu, N. Ogawa, Kate Scholberg, H. Miyabe, G. D. Megias, C. Simpson, Makoto Sakuda, L. Bernard, S. Samani, M. G. Catanesi, J. Y. Yang, Masaki Ishitsuka, M. Thiesse, F. d. M. Blaszczyk, Jl Stone, Yoshitaka Kuno, G. Pintaudi, K. Ohta, Hiroyuki Sekiya, F. Nova, Y. Kato, P. Weatherly, K. Abe, S. Han, T. Sugimoto, Hirokazu Ishino, Masayuki Nakahata, N. McCauley, C. M. Nantais, B. Zaldivar, T. Nakadaira, S. Sakai, E. Kearns, A. Goldsack, Michael B. Smy, M. Jakkapu, R. A. Wendell, Y. Uchida, M. Posiadala-Zezula, Y. Oyama, B. Bodur, C. Vilela, G. De Rosa, K. Sato, G. Collazuol, Luis Labarga, J. Kameda, J. Feng, D. Fukuda, T. Niwa, P. Mijakowski, P. Paganini, B. D. Xu, N. J. Griskevich, P. Mehta, T. Horai, C. K. Jung, Lester D.R. Thompson, Yusuke Koshio, D. Bravo-Berguño, S. Matsuno, T. Tsukamoto, K. Hagiwara, S. Hirota, M. Koshiba, Y. Nakajima, G.D. Barr, Yuuki Nakano, T. Mochizuki, Stephen J. Jenkins, I. T. Lim, T. Ishida, Y. Isobe, L. N. Machado, T. Boschi, John Walker, Th. A. Mueller, Hiroshi Ito, B. W. Pointon, M. Taani, R. Akutsu, A. A. Sztuc, Makoto Hasegawa, L. H. V. Anthony, Tatsuya Kikawa, Volodymyr Takhistov, Yousuke Kataoka, N. W. Prouse, S. V. Cao, A. Pritchard, M. Tsukada, M. Gonin, Yoshihiro Suzuki, Y. Nagao, A. Minamino, M. Shinoki, M. Malek, J. Y. Kim, J. L. Raaf, S. Yamamoto, T. Nakamura, S. Locke, M. Jiang, A. Coffani, Yasuhiro Kishimoto, O. Stone, Takashi Kobayashi, T. Towstego, T. Hasegawa, S. Mine, Takahiko Matsubara, K. Frankiewicz, N. Piplani, A. Orii, Mark R. Vagins, S. B. Kim, A. K. Ichikawa, K. E. Nakamura, S. Molina Sedgwick, B. Richards, Ken Sakashita, W. Ma, R. Matsumoto, B. Quilain, J. F. Martin, M. Friend, Masato Shiozawa, Y. Choi, L. Cook, A. Suzuki, Masashi Yokoyama, T. Ishizuka, Tsuyoshi Nakaya, J. S. Jang, Masahiro Kuze, R. Sasaki, Henry W. Sobel, Kyoshi Nishijima, Natalv Ospina, Shigetaka Moriyama, H. A. Tanaka, S. Imaizumi, K. Iwamoto, T. Tashiro, Manabu Tanaka, Yoshinari Hayato, C. Yanagisawa, T. Wester, Yoshitaka Itow, M. Miura, M. J. Wilking, Takashi Yoshida, F. Iacob, E. Radicioni, John Hill, D. L. Wark, Y. Takahira, R. Wang, M. Mori, F. Di Lodovico, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Super-Kamiokande, and Super-Kamiokande Collaboration
Subjects: Astrophysics::High Energy Astrophysical Phenomena, General Physics and Astronomy, FOS: Physical sciences, Astrophysics, KAMIOKANDE, gamma ray: burst, 01 natural sciences, Fluence, Coincidence, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Positron, F03 Ultra-high energy phenomena of cosmic rays, neutrino: energy, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], 010303 astronomy & astrophysics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, background, High Energy Physics::Phenomenology, F22 Neutrinos from supernova remnant and other astronomical objects, network, positron, High Energy Physics::Experiment, C43 Underground experiments, Underground experiments Ultra-high energy phenomena of cosmic rays Neutrinos from supernova remnant and other astronomical objects, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Super-Kamiokande, Gamma-ray burst, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Energy (signal processing), Bar (unit)
Abstract: A search for neutrinos produced in coincidence with Gamma-Ray Bursts(GRB) was conducted with the Super-Kamiokande (SK) detector. Between December 2008 and March 2017, the Gamma-ray Coordinates Network recorded 2208 GRBs that occurred during normal SK operation. Several time windows around each GRB were used to search for coincident neutrino events. No statistically significant signal in excess of the estimated backgrounds was detected. The $\bar\nu_e$ fluence in the range from 8 MeV to 100 MeV in positron total energy for $\bar\nu_e+p\rightarrow e^{+}+n$ was found to be less than $\rm 5.07\times10^5$ cm$^{-2}$ per GRB in 90\% C.L. Upper bounds on the fluence as a function of neutrino energy were also obtained., Comment: 29 pages, 16 figures, 5 tables, accepted by PTEP
Published: 2021
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13. Follow-up of GWTC-2 gravitational wave events with neutrinos from the Super-Kamiokande detector

Author: Vincenzo Berardi, A. A. Sztuc, M. Thiesse, K. Iwamoto, P. Mehta, M. Koshiba, S. J. Jenkins, M. Taani, R. G. Park, H. Okazawa, Y. Takeuchi, Patrick de Perio, Kimihiro Okumura, K. Martens, S. Han, S. Cao, Thomas A. Mueller, E. Kearns, M. R. Vagins, David Hadley, Henry W. Sobel, Yoshinari Hayato, K. Yasutome, S. Mine, K. M. Tsui, Masashi Yokoyama, T. Towstego, C. Bronner, J. Y. Yang, Yasuhiro Takemoto, O. Drapier, J. McElwee, Gianfranca De Rosa, Makoto Miura, E. Radicioni, M. B. Smy, J. S. Jang, Shuhei Watanabe, A. Konaka, Marco Mattiazzi, David Wark, B. Zaldivar, J. Migenda, M. Lamoureux, T. Ishizuka, M. Friend, S. Zsoldos, B. Bodur, H. A. Tanaka, T. Matsubara, N. W. Prouse, Katsuki Hiraide, Tsuyoshi Nakaya, C. W. Walter, Masaki Ishitsuka, S. Locke, S. Miki, Hirokazu Ishino, J. Feng, Sonia El Hedri, Masahiro Kuze, Yusuke Koshio, John Walker, D. Barrow, S. Mohan Lakshmi, J. L. Raaf, M. Mori, Hiroaki Menjo, Y. Sonoda, F. Nova, S. Sano, R. Sasaki, Marcus O'Flaherty, Takaaki Kajita, Yoshitaka Itow, G. Collazuol, M. Jakkapu, Natalv Ospina, Mark Scott, Y. Nishimura, Hiroyuki Sekiya, Soo-Bong Kim, B. Quilain, James Hill, G. Pronost, M. Inomoto, Y. Fukuda, L. Wan, T. Yano, John Fraser Martin, I. T. Lim, T. Boschi, Y. Maekawa, K. Nakamura, M. J. Wilking, J. Bian, K. Abe, L. Bernard, Y. Nagao, A. Minamino, Tatsushi Kinoshita, S. Izumiyama, C. K. Jung, Hiroshi Ito, N. Jeff Griskevich, P. Paganini, Y. Kanemura, M. Ikeda, A. Giampaolo, Masato Shiozawa, L. Ludovici, B. D. Xu, Yoshihiro Suzuki, S. Moriyama, F. Iacob, M. Shinoki, M. Gonin, J. Xia, L. H. V. Anthony, Masayuki Nakahata, J. G. Learned, R. Matsumoto, Takuto Suganuma, Y. Uchida, A. Ali, Kate Scholberg, Pablo Fernandez, N. McCauley, L. N. Machado, H. K. Tanaka, S. Samani, M. Malek, M. G. Catanesi, Junjie Jiang, William R. Kropp, T. Sekiguchi, M. Harada, S. Chen, Kenzo Nakamura, H. Ozaki, S. Yamamoto, Yuuki Nakano, A. T. Suzuki, K. Okamoto, Hussain Kitagawa, B. Jamieson, G. D. Megias, B. W. Pointon, A. K. Ichikawa, T. Nakadaira, J. Kameda, Lester D.R. Thompson, Yuichi Oyama, V. Takhistov, P. Mijakowski, S. Sakai, T. Hasegawa, Atsushi Takeda, G. Pintaudi, Yasuhiro Nakajima, N. F. Calabria, Joanna Zalipska, K. Sakashita, T. Nakamura, N. Piplani, Intae Yu, N. Ogawa, M. Posiadala-Zezula, C. Yanagisawa, J. Y. Kim, A. Goldsack, S. Nakayama, R. A. Wendell, Y. Kataoka, A. Coffani, O. Stone, Takashi Kobayashi, D. Martin, K. Sato, G.D. Barr, Tatsuya Kikawa, L. Marti, M. Hartz, T. Tashiro, K. Nishijima, T. Wester, Justyna Lagoda, Jingyuan Gao, W. Ma, A. Takenaka, T. Tsukamoto, L. Labarga, T. Ishida, B. Richards, Shintaro Ito, Y. Kotsar, C. Vilela, FD Lodovico, L. Cook, R. Akutsu, Lamoureux, Mathieu, Abe, Ko, Bronner, Christophe, Hayato, Yoshinari, Hiraide, Katsuki, Ikeda, Motoyasu, Kameda, Jun, Kanemura, Yuki, Kataoka, Yousuku, Miki, Shintaro, Miura, Makoto, Moriyama, Shigetaka, Nagao, Yoshiki, Nakahata, Masayuki, Nakayama, Shoei, Okamoto, Kohei, Pronost, Guillaume, Sekiya, Hiroyuki, Shiozawa, Masato, Sonoda, Yutaro, Suzuki, Yoichiro, Takeda, Atsushi, Takemoto, Yasuhiro, Takenaka, Akira, Tanaka, Hidekazu, Watanabe, Shuhei, Yano, Takatomi, Han, Seungho, Kajita, Takaaki, Okumura, Kimihiro, Tashiro, Takuya, Xia, Junjie, Megias, Guillermo, Labarga, Lui, Marti, Llui, Zaldivar, Bryan, Pointon, Barry W., Kearns, Edward, Raaf, Jennifer L., Wan, Linyan, Wester, Thoma, Bian, Jianming, Griskevich, N. Jeff, Kropp, William R., Locke, Scott, Mine, Shunichi, Smy, Michael, Sobel, Henry W., Takhistov, Volodymyr, Hill, Jame, Kim, Jae Yool, Lim, In Taek, Park, Ryeong Gyoon, Bodur, Baran, Scholberg, Kate, Walter, Chri, Bernard, Laura, Coffani, Alice, Drapier, Olivier, El Hedri, Sonia, Giampaolo, Alberto, Gonin, Michel, Mueller, Thomas A., Paganini, Pascal, Quilain, Benjamin, Ishizuka, Takeharu, Nakamura, Taku, Jang, Jae Seung, Learned, John G., Cao, Son, Anthony, Lauren H. V., Martin, Daniel, Scott, Mark, Sztuc, Artur A., Uchida, Yoshi, Berardi, Vincenzo, Catanesi, Maria Gabriella, Radicioni, Emilio, Calabria, Nicola F., Machado, Lucas N., De Rosa, Gianfranca, Collazuol, Gianmaria, Iacob, Fabio, Mattiazzi, Marco, Ospina, Natalv, Ludovici, Lucio, Maekawa, Yuto, Nishimura, Yasuhiro, Friend, Megan, Hasegawa, Takuya, Ishida, Taku, Kobayashi, Takashi, Jakkapu, Mahesh, Matsubara, Tsunayuki, Nakadaira, Takeshi, Nakamura, Kenzo, Oyama, Yuichi, Sakashita, Ken, Sekiguchi, Tetsuro, Tsukamoto, Toshifumi, Boschi, Tommaso, Di Lodovico, Francesca, Gao, Jingyuan, Migenda, Jost, Taani, Mahdi, Zsoldos, Stephane, Nakano, Yuuki, Ozaki, Hironori, Suzuki, Atsumu, Takeuchi, Yasuo, Yamamoto, Shotaro, Kotsar, Yurii, Ali, Ajmi, Feng, Jiahui, Kikawa, Tatsuya, Mori, Masamitsu, Nakaya, Tsuyoshi, Wendell, Roger, Yasutome, Kenji, Fernández, Pablo, Mccauley, Neil, Mehta, Pruthvi, Tsui, Ka Ming, Fukuda, Yoshiyuki, Itow, Yoshitaka, Menjo, Hiroaki, Sato, Kazufumi, Lagoda, Justyna, Lakshmi, S. Mohan, Mijakowski, Piotr, Zalipska, Joanna, Jiang, Junjie, Jung, Chang K., Vilela, Cristovao, Wilking, Michael, Yanagisawa, Chiaki, Harada, Masayuki, Ishino, Hirokazu, Ito, Shintaro, Kitagawa, Hussain, Koshio, Yusuke, Ma, Wenjie, Piplani, Nishtha, Sakai, Seiya, Barr, Gile, Barrow, Danial, Cook, Laurence, Goldsack, Alexander, Samani, Soniya, Wark, David, Nova, Federico, Yang, Jeong Yeol, Jenkins, Sam J., Malek, Matthew, Mcelwee, Jordan, Stone, Owen, Thiesse, Matthew D., Thompson, Lee F., Okazawa, Hiroko, Kim, Soo Bong, Yu, Intae, Ichikawa, Atsuko, Nakamura, Kiseki, Nishijima, Kyoshi, Koshiba, Masatoshi, Iwamoto, Konosuke, Nakajima, Yasuhiro, Ogawa, Natsumi, Yokoyama, Masashi, Martens, Kai, Vagins, Mark, Kuze, Masahiro, Izumiyama, Shota, Inomoto, Michitaka, Ishitsuka, Masaki, Ito, Hiroshi, Kinoshita, Tatsushi, Matsumoto, Ryo, Shinoki, Masataka, Suganuma, Takuto, Martin, John Fraser, Tanaka, Hirohisa, Towstego, Trevor, Akutsu, Ryosuke, de Perio, Patrick, Hartz, Mark, Konaka, Akira, Prouse, Nick, Chen, Shaomin, Xu, Benda D., Posiadala-Zezula, Magdalena, Hadley, David, O'Flaherty, Marcu, Richards, Benjamin, Jamieson, Blair, Walker, John, Minamino, Akihiro, Pintaudi, Ggiorgio, Sano, Shiochi, and Sasaki, Ryota
Subjects: Physics, Particle physics, Gravitational wave, Cherenkov detector, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, Detector, Flux, law.invention, law, Time windows, High Energy Physics::Experiment, Total energy, Neutrino, Super-Kamiokande
Abstract: Super-Kamiokande (SK) is a 50-kt water Cherenkov detector, instrumented with $\sim 13$k photo-multipliers and running since 1996. It is sensitive to neutrinos with energies ranging from 4.5 MeV to several TeV. A new framework has been developed for the follow-up of gravitational wave (GW) alerts issued by the LIGO-Virgo collaboration (LVC). Neutrinos are searched for, using a 1000-second time window centered on the alert time and in both SK low-energy and high-energy samples. Such observation can then be used to constrain the neutrino emission from the GW source. The significance of potential signals has been obtained by comparing neutrino direction with the localization of the GW. The computation of limits on incoming neutrino flux and on the total energy emitted in neutrinos by the source has been performed for the different neutrino flavors. The results using the LVC GWTC-2 catalog (covering O3a period) are presented, as well as the outlooks for the future real-time public release of follow-ups for the O4 period (in 2022) and beyond.
Published: 2021

14. Search for proton decay via p→e+π0 and p→μ+π0 with an enlarged fiducial volume in Super-Kamiokande I-IV

Author: J. S. Jang, B. Bodur, Yuji Kishimoto, L. H. V. Anthony, Rongkun Wang, J. L. Raaf, L. Labarga, K. Nakamura, T. Niwa, T. Kobayashi, F. d. M. Blaszczyk, M. Jakkapu, M. Hartz, Y. Nishimura, P. Weatherly, S. Moriyama, Y. Isobe, T. Boschi, Hiroshi Ito, B. Richards, G. Santucci, Masayuki Nakahata, N. Ospina, Y. Uchida, V. Takhistov, C. K. Jung, M. Mori, M. Taani, Y. Sonoda, M. Ikeda, M. Koshiba, P. de Perio, T. Yano, A. T. Suzuki, K. Okamoto, J. F. Martin, Masato Shiozawa, Y. Choi, Yoshitaka Itow, H. Okazawa, G. Pintaudi, E. Radicioni, L. Ludovici, W. R. Kropp, K. Sakashita, Yutaka Nakajima, C. Xu, Hiroaki Menjo, P. Paganini, M. Miura, T. Nakadaira, G. Pronost, F. Iacob, R. G. Park, B. D. Xu, N. F. Calabria, O. Drapier, Makoto Sakuda, Ke. Nakamura, M. Jiang, A. Coffani, M. Posiadala-Zezula, T. Horai, Ko Okumura, H. W. Sobel, S. Matsuno, A. Giampaolo, S. Molina Sedgwick, Yuuki Nakano, T. Mochizuki, T. Tashiro, T. Towstego, S. Imaizumi, K. Hagiwara, H.A. Tanaka, S. Cao, S. Sakai, B. W. Pointon, F. Nova, R. Sasaki, R. Matsumoto, Intae Yu, P. Mehta, Y. Kataoka, D. Fukuda, C. Bronner, M. G. Catanesi, S. Han, Pablo Fernandez, H. Miyabe, M. J. Wilking, Yuichi Oyama, R. P. Litchfield, C. M. Nantais, D. Bravo-Berguño, B. Quilain, J. G. Learned, K. Yasutome, S. Zsoldos, Y. Kuno, Ke. Abe, K. Nishijima, S. Locke, Atsushi Takeda, J. C. Hill, K. Ohta, T. Wester, E. Kearns, Vincenzo Berardi, N. Piplani, G. De Rosa, Masashi Yokoyama, J. L. Stone, David A. Wark, J. Y. Yang, M. Tsukada, Y. Takahira, Masaki Ishitsuka, M. Thiesse, K. Iwamoto, G.D. Barr, A. Konaka, S. J. Jenkins, M. R. Vagins, J. Walker, N. J. Griskevich, A. Ali, Yusuke Koshio, Y. Takemoto, A. Pritchard, W. Y. Ma, D. Barrow, L. F. Thompson, T. Ishizuka, Makoto Hasegawa, Y. Nagao, J. McElwee, A. Minamino, Tsuyoshi Nakaya, B. Jamieson, M. Shinoki, K. Frankiewicz, N. McCauley, S. B. Kim, I. T. Lim, S. Yamamoto, T. Matsubara, J. Y. Kim, A. Orii, S. El Hedri, J. Feng, L. Cook, Y. Takeuchi, T. Kajita, J. Bian, H. K. Tanaka, Seiko Hirota, T. Kikawa, M. Gonin, J. Xia, M. Friend, Masaaki Tanaka, N. W. Prouse, C. W. Walter, T. Sugimoto, Hiroyuki Sekiya, Y. Fukuda, L. Wan, R. Akutsu, Y. Hayato, T. Sekiguchi, Yasunari Suzuki, T. Shiozawa, C. Vilela, Ll. Marti, T. Yoshida, Song Chen, K. S. Ganezer, Yuto Ashida, T. Tsukamoto, T. Okada, T. Nakamura, N. Ogawa, T. Ishida, C. Yanagisawa, A. Goldsack, S. Nakayama, R. A. Wendell, A. Takenaka, K. Sato, A. K. Ichikawa, J. Kameda, Th. A. Mueller, Shintaro Ito, P. Mijakowski, Kalen Martens, Kate Scholberg, S. Mine, K. M. Tsui, Takehisa Hasegawa, M. Lamoureux, Hirokazu Ishino, Chris Simpson, G. Collazuol, F. Di Lodovico, M. Kuze, M. Inomoto, A. A. Sztuc, M. B. Smy, B. Zaldivar, Yuta Kato, L. N. Machado, and M. Harada
Subjects: Physics, 010308 nuclear & particles physics, Proton decay, Detector, 01 natural sciences, Lower limit, Nuclear physics, Volume (thermodynamics), 0103 physical sciences, Pi, Atmospheric neutrino, 010306 general physics, Fiducial marker, Super-Kamiokande
Abstract: We have searched for proton decay via p→e+π0 and p→μ+π0 modes with the enlarged fiducial volume data of Super-Kamiokande from April 1996 to May 2018, which corresponds to 450 kton·years exposure. We have accumulated about 25% more livetime and enlarged the fiducial volume of the Super-Kamiokande detector from 22.5 kton to 27.2 kton for this analysis, so that 144 kton·years of data, including 78 kton·years of additional fiducial volume data, has been newly analyzed. No candidates have been found for p→e+π0 and one candidate remains for p→μ+π0 in the conventional 22.5 kton fiducial volume and it is consistent with the atmospheric neutrino background prediction. We set lower limits on the partial lifetime for each of these modes: τ/B(p→e+π0)>2.4×1034 years and τ/B(p→μ+π0)>1.6×1034 years at 90% confidence level.
Published: 2020

15. Evaluation of gefitinib efficacy according to body mass index, body surface area, and body weight in patients with EGFR-mutated advanced non-small cell lung cancer

Author: Mitsuyoshi Utsugi, Reiko Sakurai, Noriaki Sunaga, Akira Mogi, Yoshio Tomizawa, Tomohito Kuwako, Tomomi Masuda, T. Ishizuka, Kyoichi Kaira, Atsushi Takise, Yosuke Miura, Ryusei Saito, Kimihiro Shimizu, Kaori Seki, Koichi Minato, Masanobu Yamada, Hisao Imai, Shinichi Ishihara, and Takeshi Hisada
Subjects: 0301 basic medicine, Oncology, Body surface area, Male, Cancer Research, Lung Neoplasms, Overweight, Toxicology, Body Mass Index, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Pharmacology (medical), Epidermal growth factor receptor, Aged, 80 and over, biology, Gefitinib, Exons, Middle Aged, ErbB Receptors, Treatment Outcome, 030220 oncology & carcinogenesis, Original Article, Female, Underweight, medicine.symptom, medicine.drug, Adult, medicine.medical_specialty, Antineoplastic Agents, Disease-Free Survival, 03 medical and health sciences, Internal medicine, medicine, Humans, Lung cancer, Protein Kinase Inhibitors, Survival analysis, Aged, Retrospective Studies, Pharmacology, business.industry, Body Weight, medicine.disease, EGFR mutations, Survival Analysis, respiratory tract diseases, 030104 developmental biology, biology.protein, Quinazolines, Advanced non-small cell lung cancer, business, Body mass index, Gene Deletion
Abstract: Purpose In patients with epidermal growth factor receptor (EGFR)-mutated, advanced, non-small cell lung cancer (NSCLC), common gefitinib-sensitive EGFR mutations that predict a greater response to therapy include the exon 19 deletion and L858R point mutation. The objective of this study was to evaluate whether body surface area (BSA), body weight (BW), and body mass index (BMI) affect gefitinib efficacy in such patients. Methods The medical charts of 138 consecutive patients with advanced NSCLC harboring sensitive EGFR mutations, who underwent gefitinib treatment, were reviewed. The median BSA and BW were used as cutoff values to evaluate their impact on gefitinib efficacy. BMI was categorized as underweight (
Published: 2017

16. Graded Dalbavancin Challenge in a Patient With Severe Vancomycin Hypersensitivity Reaction

Author: Thao Kim Tran, Jeannie D. Chan, Andrew G. Ayars, Alice S. Chau, and Kelly T Ishizuka
Subjects: Microbiology (medical), medicine.medical_specialty, medicine.drug_class, business.industry, Antibiotics, Dalbavancin, Cross reactions, Microbial Sensitivity Tests, Dermatology, Anti-Bacterial Agents, Hypersensitivity reaction, Infectious Diseases, Vancomycin, medicine, Humans, Teicoplanin, business, medicine.drug
Abstract: Cross-reactivity should be considered when treating patients with a previous hypersensitivity reaction within the same class of antibiotics that share similar chemical structures. This case report describes a patient with severe hypersensitivity reaction to vancomycin who successfully tolerated a dalbavancin graded challenge.
Published: 2019

17. Measurement of the neutrino-oxygen neutral-current quasielastic cross section using atmospheric neutrinos at Super-Kamiokande

Author: E. Kearns, Masashi Yokoyama, T. Sugimoto, T. Towstego, T. Ishizuka, Y. Hayato, Tsuyoshi Nakaya, R. Akutsu, L. H. V. Anthony, C. W. Walter, F. Di Lodovico, C. Kachulis, T. Hayashino, C. K. Jung, Y. Kuno, K. Nishijima, A. Konaka, A. Minamino, N. McCauley, C. M. Nantais, Masato Shiozawa, Y. Choi, L. Ludovici, N. J. Griskevich, M. Vagins, M. Kuze, J. L. Raaf, Yusuke Koshio, Atsushi Takeda, T. Sekiguchi, P. de Perio, B. Bodur, V. Takhistov, Hiroyuki Sekiya, S. Molina Sedgwick, Soo-Bong Kim, Y. Fukuda, L. Wan, N. F. Calabria, Ke. Nakamura, Hirokazu Ishino, Y. Isobe, Y. Takeuchi, Lester D.R. Thompson, K. Martens, Y. Nishimura, A. T. Suzuki, K. Okamoto, Hiromasa Tanaka, M. Murdoch, J. Bian, C. Vilela, T. Tsukamoto, T. Okada, C. Xu, A. Pritchard, Makoto Hasegawa, W. R. Kropp, K. Sakashita, J. F. Martin, Takaaki Kajita, Yuichi Oyama, T. Nakadaira, M. Friend, M. Thiesse, G. De Rosa, C. Simpson, J. Imber, K. M. Tsui, Ahmed Ali, M. B. Smy, R. P. Litchfield, Seiko Hirota, Xiao-yan Li, G. Collazuol, Yuta Kato, T. Ishida, Rongkun Wang, T. Kikawa, M. Gonin, J. Xia, H. K. Tanaka, M. G. Catanesi, M. Ikeda, Makoto Sakuda, M. Miura, K. Frankiewicz, Yutaka Nakajima, Ll. Marti, K. Abe, J. L. Stone, Y. Okajima, K. Iyogi, J. Y. Kim, S. Mine, A. Orii, S. Cao, L. Labarga, Yoshihiro Suzuki, R. A. Wendell, M. J. Wilking, S. Berkman, J. L. Palomino, M. Hartz, K. Choi, Pablo Fernandez, C. Bronner, Shintaro Ito, R. A. Intonti, J. G. Learned, I. T. Lim, H. Miyabe, Kate Scholberg, H. Okazawa, S. Locke, S. Matsuno, B. Quilain, A. Takenaka, F. d. M. Blaszczyk, P. Weatherly, B. Richards, M. Koshiba, R. G. Park, Ko Okumura, Ke. Abe, K. Hagiwara, Yuuki Nakano, T. Mochizuki, Sara Sussman, J. Kameda, Th. A. Mueller, P. Mijakowski, Felix Iacob, J. S. Jang, Masaki Ishitsuka, M. O. Wascko, A. Goldsack, S. Nakayama, T. Yoshida, Song Chen, R. Tacik, D. Fukuda, K. S. Ganezer, E. Radicioni, John Hill, D. L. Wark, Y. Takahira, T. Yano, M. Mori, Y. Sonoda, Yoshitaka Itow, G. Pronost, T. Nakamura, M. Murrase, C. Yanagisawa, H. W. Sobel, Y. Ashida, K. Nakamura, S. Moriyama, G. Santucci, Masayuki Nakahata, Y. Uchida, T. Hasegawa, M. Jiang, Yasuhiro Kishimoto, Takashi Kobayashi, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Super-Kamiokande, Science and Technology Facilities Council (STFC), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), DE ROSA, Gianfranca, and Et, Al
Subjects: Physics::Instrumentation and Detectors, neutrino oxygen neutral current interaction, Flux, KAMIOKANDE, 7. Clean energy, 01 natural sciences, neutrino: flux, High Energy Physics - Experiment, Physics, Particles & Fields, High Energy Physics - Experiment (hep-ex), neutrino: atmosphere, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Particle Physics Experiments, neutrino: supernova, Nuclear Experiment, Physics, neutrino nucleon: inelastic scattering, atmospheric neutrinos, Supernova, Physical Sciences, quasi-elastic cross section, Neutrino, Nucleon, channel cross section: measured, neutrino oxygen neutral current interaction, quasi-elastic cross section, atmospheric neutrinos, SuperKamiokande experiment, neutral current, Cherenkov counter: water, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astronomy & Astrophysics, EVENTS, Nuclear physics, 5/3, neutrino: spectrum, SEARCH, 0103 physical sciences, 010306 general physics, Cherenkov radiation, Science & Technology, Neutral current, background, 010308 nuclear & particles physics, Scattering, scattering, neutrino nucleus: interaction, MU, 13. Climate action, High Energy Physics::Experiment, Super-Kamiokande, oxygen, SuperKamiokande experiment, experimental results
Abstract: Neutral current (NC) interactions of atmospheric neutrinos on oxygen form one of the major backgrounds in the search for supernova relic neutrinos with water-based Cherenkov detectors. The NC channel is dominated by neutrino quasi-elastic (NCQE) scattering off nucleons inside $^{16}$O nuclei. In this paper we report the first measurement of NCQE cross section using atmospheric neutrinos at Super-Kamiokande (SK). The measurement used 2,778 live days of SK-IV data with a fiducial volume of 22.5 kiloton water. Within the visible energy window of 7.5-29.5 MeV, we observed $117$ events compared to the expected $71.9$ NCQE signal and $53.1$ background events. Weighted by the atmospheric neutrino spectrum from 160 MeV to 10 GeV, the flux averaged NCQE cross section is measured to be $(1.01\pm0.17(\text{stat.})^{+0.78}_{-0.30}(\text{sys.}))\times10^{-38}$ cm$^2$., Comment: 11 pages, 9 figures, submitted to PRD
Published: 2019

18. Real-time supernova neutrino burst monitor at Super-Kamiokande

Author: A. T. Suzuki, J. F. Martin, T. Nakadaira, G. Carminati, Makoto Sakuda, K. Iyogi, J. L. Raaf, K. Sakashita, K. Kaneyuki, Takaaki Kajita, T. Sekiguchi, E. Kearns, R. A. Wendell, Masashi Yokoyama, Yasunari Suzuki, Y. Hayato, M. Ikeda, John Hill, S. B. Kim, J. Y. Kim, M. Goldhaber, S. N. Smith, Seiko Hirota, T. Kikawa, C. Yanagisawa, Yejin Zhang, T. Ishizuka, L. Marti, K. Tateishi, Tsuyoshi Nakaya, J. S. Jang, A. Himmel, Song Chen, K. Nishijima, W. R. Kropp, S. Tobayama, Takaaki Mori, Kate Scholberg, W. E. Keig, V. Takhistov, Atsushi Takeda, Shigeki Tasaka, E. Richard, J. L. Stone, L. R. Sulak, K. Ieki, Yusuke Suda, Hirokazu Ishino, K. S. Ganezer, R. J. Wilkes, S. Moriyama, R. Tacik, Masayuki Nakahata, I. Kametani, M. Miura, L. Labarga, T. Kobayashi, K. P. Lee, C. K. Jung, Yoshitaka Itow, J. Imber, Masato Shiozawa, Y. Choi, Koh Ueno, H.A. Tanaka, M. J. Wilking, Yasuhiro Kishimoto, A. Konaka, M. B. Smy, Kimihiro Okumura, T. Tomura, H. Okazawa, Y. Kuno, S. Nakayama, T. Yokozawa, T. Tsukamoto, C. Bronner, T. Akiri, B. L. Hartfiel, S. Mine, S. Berkman, J. G. Learned, J. Gustafson, S. Matsuno, T. McLachlan, Takehisa Hasegawa, J. Kameda, P. Fernandez, K. Connolly, P. Mijakowski, K. Choi, K. Huang, Kazuhiro Suzuki, A. Kibayashi, Y. Koshio, T. Ishida, M. Koshiba, H. K. Tanaka, M. R. Vagins, A. Murakami, A. Minamino, G. Mitsuka, I. T. Lim, P. de Perio, T. Yano, A. L. Renshaw, Kenzo Nakamura, Yuichi Oyama, R. Yamaguchi, K. Abe, Y. Totsuka, Susumu Takahashi, T. Wongjirad, Y. Takeuchi, T. Ishii, K. Martens, Y. Nishimura, C. W. Walter, N. Hong, Joshua Hignight, Hiroyuki Sekiya, Y. Fukuda, Yuuki Nakano, T. J. Irvine, Y. Haga, P. Weatherly, and H. W. Sobel
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), Physics, 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Solar neutrino, High Energy Physics::Phenomenology, FOS: Physical sciences, Astronomy, Astronomy and Astrophysics, Astrophysics, Solar neutrino problem, 01 natural sciences, Cosmic neutrino background, Astrophysics - Solar and Stellar Astrophysics, Neutrino detector, 0103 physical sciences, Measurements of neutrino speed, High Energy Physics::Experiment, Neutrino astronomy, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Super-Kamiokande, 010303 astronomy & astrophysics, Solar and Stellar Astrophysics (astro-ph.SR)
Abstract: We present a real-time supernova neutrino burst monitor at Super-Kamiokande (SK). Detecting supernova explosions by neutrinos in real time is crucial for giving a clear picture of the explosion mechanism. Since the neutrinos are expected to come earlier than light, a fast broadcasting of the detection may give astronomers a chance to make electromagnetic radiation observations of the explosions right at the onset. The role of the monitor includes a fast announcement of the neutrino burst detection to the world and a determination of the supernova direction. We present the online neutrino burst detection system and studies of the direction determination accuracy based on simulations at SK., 15 pages, 8 figures, accepted for publication in Astroparticle Physics
Published: 2016

19. First-line gefitinib treatment in elderly patients (aged ≥75 years) with non-small cell lung cancer harboring EGFR mutations

Author: Yoshio Tomizawa, Kimihiro Shimizu, Masanobu Yamada, Ryusei Saito, Koichi Minato, Tomohito Kuwako, Tomomi Masuda, T. Ishizuka, Kaori Seki, Kyoichi Kaira, Noriaki Sunaga, Reiko Yoshino, Mitsuyoshi Utsugi, Akira Mogi, Hisao Imai, Atsushi Takise, Yosuke Miura, Shinichi Ishihara, and Takeshi Hisada
Subjects: Male, Oncology, Aging, Cancer Research, Lung Neoplasms, Toxicology, Severity of Illness Index, Tyrosine-kinase inhibitor, Japan, Carcinoma, Non-Small-Cell Lung, Pharmacology (medical), Epidermal growth factor receptor, Aged, 80 and over, biology, Incidence, Standard treatment, Gefitinib, Rash, ErbB Receptors, Female, Drug Eruptions, Drug Monitoring, medicine.symptom, medicine.drug, medicine.medical_specialty, medicine.drug_class, Antineoplastic Agents, Internal medicine, medicine, Humans, Lung cancer, Protein Kinase Inhibitors, neoplasms, Survival analysis, Aged, Retrospective Studies, Pneumonitis, Pharmacology, business.industry, medicine.disease, Survival Analysis, respiratory tract diseases, Mutation, Quinazolines, biology.protein, Feasibility Studies, business, Follow-Up Studies
Abstract: The efficacy of gefitinib [an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor] in elderly patients with non-small cell lung cancer (NSCLC) and EGFR mutation has not been elucidated. Therefore, the objective of this study was to investigate the efficacy and feasibility of gefitinib in elderly chemotherapy-naive patients with NSCLC harboring sensitive EGFR mutations. We retrospectively evaluated the clinical effects of gefitinib as a first-line treatment for elderly (≥75 years) NSCLC patients with EGFR mutations (exon 19 deletion or exon 21 L858R mutation). All patients were initially treated with gefitinib (250 mg/day) at seven institutions. Between January 2006 and December 2012, 62 patients (17 men, 45 women) with a median age of 80 years (range, 75–89 years) were included in our analysis. The overall response and disease control rates were 61.2 and 83.8 %, respectively, and the median progression-free survival and overall survival were 13.2 and 19.0 months, respectively. Common adverse events included rash, diarrhea, and liver dysfunction. Major grade 3 or 4 toxicities included skin rash (3.2 %) and increased levels of aspartate aminotransferase or alanine aminotransferase (21.0 %). Gefitinib treatment was discontinued owing to adverse events of liver dysfunction in 3 patients, drug-induced pneumonitis in 2, and diarrhea in 1. First-line gefitinib could be a preferable standard treatment in elderly patients with advanced NSCLC harboring sensitive EGFR mutations.
Published: 2015

20. Local application of Aqua Titan improves symptoms of temporomandibular joint muscle disorder: a preliminary study

Author: Yoshiyuki Yonehara, N. Tsukimura, T. Ishizuka, Kazuya Honda, Kiyomi Kohinata, and Kunihito Matsumoto
Subjects: Adult, Male, Muscle tissue, medicine.medical_specialty, Activities of daily living, Adolescent, Visual analogue scale, Administration, Topical, Muscle disorder, Masseter muscle, stomatognathic system, Activities of Daily Living, medicine, Humans, Pain Management, In patient, Aged, Pain Measurement, Titanium, Masseter Muscle, business.industry, Middle Aged, Temporomandibular Joint Disorders, Temporomandibular joint, Treatment Outcome, medicine.anatomical_structure, Otorhinolaryngology, Physical therapy, Joint disorder, Female, Surgery, Oral Surgery, business
Abstract: Aqua Titan (AT), comprising microscopic titanium particles dispersed in water, has been reported to have beneficial effects on muscle tissue. This study investigated the effects of local application of AT on symptoms in patients with muscle disorders of the temporomandibular joint (TMJ) compared to patients with joint disorders of the TMJ. Sixteen patients with unilateral masseter muscle pain during motion (muscle disorder group) and six patients with unilateral TMJ pain during motion (joint disorder group) applied an AT-permeated patch over the painful area every night for 2 weeks. Symptoms were evaluated clinically at the initial visit and 1 and 2 weeks later. Clinical symptoms in the joint disorder group showed no tendency towards improvement after 2 weeks. In contrast, mouth opening range with/without pain, visual analogue scale (VAS) scores for pain during mouth opening and eating, and activities of daily living (ADL) scores in the muscle disorder group were improved significantly after 2 weeks. Multiple comparison tests in the muscle disorder group showed significant improvements in the VAS for eating and ADL score after 1 week. These results suggest that the AT patch has a potential supplementary role in the treatment of patients with muscle disorders of the TMJ.
Published: 2015

21. Supernova Relic Neutrino search with neutron tagging at Super-Kamiokande-IV

Author: Y. Takeuchi, T.S. Tanaka, K. Nishikawa, C. Yanagisawa, A. T. Suzuki, K. Nishijima, L. R. Sulak, Hirokazu Ishino, Takaaki Kajita, J. F. Martin, Yuichi Oyama, R. A. Wendell, T. Nakadaira, P. dePerio, M. B. Smy, H. W. Sobel, Koh Ueno, Atsushi Takeda, A. Konaka, Yusuke Koshio, Makoto Sakuda, Y. Nishimura, Takaaki Mori, Shigeki Tasaka, J. L. Stone, Y. Hayato, S. Nakayama, J. L. Raaf, R. Tacik, R. Yamaguchi, K. Nakamura, I. Taylor, C. K. Jung, G. Carminati, K. Abe, A. Minamino, T. Tomura, A. Murakami, C. W. Walter, T. Yokozawa, H. Okazawa, K. Iyogi, John Hill, S. Moriyama, M. Ikeda, T. Yano, Masato Shiozawa, Y. Choi, Masayuki Nakahata, G. Mitsuka, A. L. Renshaw, T. Tsukamoto, K. Sakashita, K. P. Lee, Joshua Hignight, I. T. Lim, L. Labarga, T. Kobayashi, Hiroyuki Sekiya, K. Choi, Y. Totsuka, Susumu Takahashi, M. J. Wilking, Kimihiro Okumura, Y. Fukuda, K. Kaneyuki, T. Wongjirad, M. Koshiba, T. Ishida, M. Vagins, M. Goldhaber, T. Sekiguchi, W. E. Keig, S. Matsuno, Yejin Zhang, K. Bays, H. Kaji, H. Sui, Song Chen, J. Kameda, Yuuki Nakano, S. N. Smith, Yoshitaka Itow, Yasunari Suzuki, Y. Kuno, P. Mijakowski, H. Kikawa, J. G. Learned, W. R. Kropp, S. Tobayama, Zishuo Yang, Kate Scholberg, M. Dziomba, Kazuhiro Suzuki, H. Zhang, T. McLachlan, Ll. Marti, E. Kearns, S. Barkman, K. Martens, S. Mine, K. S. Ganezer, Masashi Yokoyama, S. B. Kim, J. Y. Kim, K. Huang, A. Kibayashi, K. Ieki, R. J. Wilkes, T. Ishii, T. Ishizuka, Tsuyoshi Nakaya, T. Akiri, T. Hasegawa, Yasuhiro Kishimoto, Y. Takenaga, M. Miura, J. S. Jang, K. Connolly, and J. Imber
Subjects: Physics, Particle physics, Physics - Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Astronomy and Astrophysics, Photon energy, High Energy Physics - Experiment, Nuclear physics, Supernova, Neutron capture, Neutron, High Energy Physics::Experiment, Experimental methods, Neutrino, Super-Kamiokande, Nuclear Experiment, Charged current
Abstract: A search for Supernova Relic Neutrinos $\bar{\nu}_e$'s is first conducted via inverse-beta-decay by tagging neutron capture on hydrogen at Super-Kamiokande-IV. The neutron tagging efficiency is determined to be $(17.74\pm0.04_{stat.}\pm1.05_{sys.})%$, while the corresponding accidental background probability is $(1.06\pm0.01_{stat.}\pm 0.18_{sys.})$%. Using 960 days of data, we obtain 13 inverse-beta-decay candidates in the range of $E_{\bar{\nu}_e}$ between 13.3 MeV and 31.3 MeV. All of the observed candidates are attributed to background. Upper limits at 90% C.L. are calculated in the absence of a signal., Comment: 6 pages, 4 figures
Published: 2015
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22. Search for nucleon decay into charged antilepton plus meson in 0.316 megaton·years exposure of the Super-Kamiokande water Cherenkov detector

Author: A. T. Suzuki, Atsushi Takeda, J. F. Martin, N. D. Patel, Yusuke Suda, C. Vilela, T. Nakadaira, C. Xu, Makoto Sakuda, K. Ito, H. W. Sobel, Y. Takeuchi, T. Kajita, B. Quilain, M. B. Smy, Y. Sonoda, M. Elnimr, K. Sakashita, A. Konaka, Francesco Muto, Xiao-yan Li, T. Hasegawa, A. Cole, J. L. Stone, Y. Okajima, Yusuke Koshio, Ll. Marti, H. K. Tanaka, Kimihiro Okumura, M. Goldhaber, A. Pritchard, Yoshitaka Itow, J. L. Raaf, M. Miura, J. L. Palomino, R. A. Wendell, K. Choi, Pablo Fernandez, L. R. Sulak, C. Kachulis, J. Amey, T. Hayashino, H.A. Tanaka, G. Pronost, M. Friend, S. Cao, N. McCauley, C. M. Nantais, K. Huang, Z. Li, Song Chen, Makoto Hasegawa, C. W. Walter, Shintaro Ito, A. Kibayashi, C Shimpson, C. Bronner, Shigeki Tasaka, Lester D.R. Thompson, S. Tobayama, J. G. Learned, D. L. Wark, Takahiro Hiraki, M. Koshiba, S. N. Smith, Y. M. Zhang, J. S. Jang, R. G. Park, T. Tomura, K. S. Ganezer, S. Nakayama, Hiroyuki Sekiya, H. Nagata, A. Takenaka, F. d. M. Blaszczyk, H. Okazawa, M. J. Wilking, Soo-Bong Kim, Y. Fukuda, I. T. Lim, Takhistov, Yuichi Oyama, L. Wan, L. Labarga, M. Jiang, T. Nakamura, R. P. Litchfield, Ke. Abe, Takashi Kobayashi, T. Tsukamoto, C. Yanagisawa, S. Berkman, P. Weatherly, J. Kameda, A. Minamino, K. Abe, Yuji Kishimoto, S. Matsuno, Lhv Anthony, T. Ishida, P. Mijakowski, Kalen Martens, T. Yano, B. Richards, R. Akutsu, Ke. Nakamura, M. O. Wascko, R. Tacik, D. Fukuda, K. Kaneyuki, Yuuki Nakano, Y. Nishimura, Yoshihiro Suzuki, Y. Totsuka, Jy Kim, A. Himmel, R. G. Calland, K. Nishijima, T. Sekiguchi, Erin O'Sullivan, F. Di Lodovico, Y. Kuno, Yuta Kato, C. K. Jung, T. Ishii, M. Ikeda, Masato Shiozawa, Y. Choi, Y. Hayato, S. Locke, J. C. Hill, E. Kearns, Seiko Hirota, Masashi Yokoyama, T. Ishizuka, Tsuyoshi Nakaya, M. Hartz, K. Iyogi, W. Y. Ma, R. J. Wilkes, Hirokazu Ishino, Vagins, S. Mine, K. M. Tsui, J. Gustafson, Kate Scholberg, W. R. Kropp, K. Nakamura, K. Frankiewicz, A. Orii, S. Moriyama, G. Santucci, Masayuki Nakahata, Y. Uchida, and M. Murase
Subjects: Physics, Particle physics, Proton, Meson, 010308 nuclear & particles physics, Cherenkov detector, Nuclear Theory, 01 natural sciences, law.invention, Nuclear physics, Pion, law, 0103 physical sciences, High Energy Physics::Experiment, Neutron, Nuclear Experiment, 010306 general physics, Nucleon, Super-Kamiokande, Lepton
Abstract: We have searched for proton decays into a charged antilepton (e+, μ+) plus a meson (η, ρ0, ω) and for neutron decays into a charged antilepton (e+, μ+) plus a meson (π−, ρ−) using Super-Kamiokande I-IV data, corresponding to 0.316 megaton⋅years of exposure. This measurement updates the previous published result by using 2.26 times more data and improved analysis methods. No significant evidence for nucleon decay is observed and lower limits on the partial lifetime of the nucleon are obtained. The limits range from 3×1031 to 1×1034 years at 90% confidence level, depending on the decay mode.
Published: 2017

23. Search for proton decay via p→e+π0 and p→μ+π0 in 0.31 megaton·years exposure of the Super-Kamiokande water Cherenkov detector

Author: M. J. Wilking, H. W. Sobel, Y. Takeuchi, Y. Totsuka, T. Wongjirad, T. Kajita, Tomohiko Nakajima, Yuichi Oyama, Seiko Hirota, T. Kikawa, T. Ishii, A. T. Suzuki, J. C. Hill, J. F. Martin, T. Nakadaira, M. Friend, Makoto Sakuda, Y. Nishimura, N. Hong, C. W. Walter, Joshua Hignight, Kate Scholberg, T. Sekiguchi, Erin O'Sullivan, S. N. Smith, W. R. Kropp, S. Tobayama, C. Kachulis, Atsushi Takeda, T. Tsukamoto, Shigeki Tasaka, J. Kameda, Yasunari Suzuki, J. S. Jang, J. L. Palomino, M. Koshiba, Hiroyuki Sekiya, P. Mijakowski, Kalen Martens, Y. Fukuda, Hiromasa Tanaka, R. G. Park, M. R. Vagins, Ko Okumura, K. Iyogi, Y. M. Zhang, T. Yano, V. Takhistov, S. Mine, T. J. Irvine, T. Ishida, Kazuhiro Suzuki, J. Gustafson, Takaaki Mori, Ke. Abe, P. Weatherly, Song Chen, J. L. Stone, Takehisa Hasegawa, S. Berkman, J. L. Raaf, Z. Li, K. Sakashita, A. Minamino, Y. Hayato, T. Suzuki, S. Nakayama, R. A. Wendell, Hirokazu Ishino, Yuji Kishimoto, I. T. Lim, K. Choi, K. Nakamura, Pablo Fernandez, Y. Kuno, M. Goldhaber, C. M. Nantais, R. Tacik, D. Fukuda, K. Kaneyuki, S. Moriyama, Yoshitaka Itow, T. Tomura, M. Miura, K. Huang, A. Kibayashi, Masayuki Nakahata, L. Labarga, H. Okazawa, H.A. Tanaka, T. Kobayashi, K. S. Ganezer, S. Cao, C. Bronner, J. G. Learned, S. Matsuno, C. Yanagisawa, E. Richard, Y. Haga, Yuuki Nakano, M. Hartz, R. J. Wilkes, K. Nishijima, Brandon L. Hartfiel, K. Frankiewicz, S. B. Kim, J. Y. Kim, A. Orii, C. Xu, A. Himmel, E. Kearns, A. Konaka, Masashi Yokoyama, Yusuke Koshio, T. Ishizuka, Tsuyoshi Nakaya, C. K. Jung, M. Ikeda, Masato Shiozawa, Y. Choi, Takahiro Hiraki, T. Kayano, Yusuke Suda, J. Imber, L. R. Sulak, Xiao-yan Li, Ll. Marti, M. B. Smy, and R. Akutsu
Subjects: Physics, Particle physics, Proton, 010308 nuclear & particles physics, Cherenkov detector, Proton decay, Hydrogen atom, Expected value, 7. Clean energy, 01 natural sciences, law.invention, Nuclear physics, 13. Climate action, law, 0103 physical sciences, Neutron, Neutrino, 010306 general physics, Super-Kamiokande
Abstract: We have searched for proton decay via p→e+π0 and p→μ+π0 using Super-Kamiokande data from April 1996 to March 2015, 0.306 megaton·years exposure in total. The atmospheric neutrino background rate in Super-Kamiokande IV is reduced to almost half that of phase I-III by tagging neutrons associated with neutrino interactions. The reach of the proton lifetime is further enhanced by introducing new signal criteria that select the decay of a proton in a hydrogen atom. No candidates were seen in the p→e+π0 search. Two candidates that passed all of the selection criteria for p→μ+π0 have been observed, but these are consistent with the expected number of background events of 0.87. Lower limits on the proton lifetime are set at τ/B(p→e+π0)>1.6×1034 years and τ/B(p→μ+π0)>7.7×1033 years at 90% confidence level.
Published: 2017

24. Search for Boosted Dark Matter Interacting With Electrons in Super-Kamiokande

Author: L. H. V. Anthony, Makoto Hasegawa, C. Xu, Takahiro Hiraki, Takaaki Kajita, S. Berkman, Y. Nishimura, K. Iyogi, W. Y. Ma, Y. Takeuchi, J. S. Jang, R. A. Wendell, Y. Sonoda, Seiko Hirota, Masahiro Kuze, A. Himmel, R. G. Calland, S. N. Smith, Yuichi Oyama, Atsushi Takeda, Song Chen, K. E. Nakamura, A. T. Suzuki, K. S. Ganezer, L. Labarga, R. P. Litchfield, V. Takhistov, Yoshihiro Suzuki, T. Kobayashi, M. R. Vagins, M. Ikeda, J. F. Martin, T. Nakadaira, Yoshitaka Itow, K. Nakamura, T. Ishii, M. Friend, C. Simpson, C. Bronner, Makoto Sakuda, K. Ito, J. L. Stone, G. Pronost, Shigeki Tasaka, W. R. Kropp, C. W. Walter, A. Pritchard, Y. Totsuka, C. Yanagisawa, K. Abe, S. Moriyama, Yusuke Suda, C. Vilela, C. Kachulis, T. Tsukamoto, E. Kearns, S. V. Cao, G. Santucci, Takashi Yoshida, Masayuki Nakahata, A. Cole, T. Nakamura, M. Elnimr, Y. Hayato, Francesco Muto, Y. Uchida, K. Sakashita, Masashi Yokoyama, M. Miura, J. L. Palomino, K. Nishijima, K. Frankiewicz, Hiroyuki Sekiya, T. Tomura, S. Locke, Soo-Bong Kim, M. B. Smy, N. D. Patel, Y. Fukuda, Yoshitaka Kuno, L. Wan, T. Ishizuka, H. Okazawa, Xiao-yan Li, J. Y. Kim, K. Kaneyuki, M. Goldhaber, Tsuyoshi Nakaya, J. Kameda, Ll. Marti, A. Orii, M. Koshiba, C. K. Jung, M. Hartz, J. Amey, H. A. Tanaka, M. Jiang, T. Sekiguchi, Erin O'Sullivan, S. Matsuno, M. Murase, Masato Shiozawa, Y. Choi, K. Choi, R. G. Park, John Hill, Yasuhiro Kishimoto, P. Mijakowski, M. J. Wilking, D. L. Wark, I. T. Lim, H. W. Sobel, R. J. Wilkes, D. Hamabe, T. Hayashino, A. Konaka, T. Hasegawa, Yusuke Koshio, Z. Li, R. Akutsu, Masaki Ishitsuka, B. Quilain, T. Ishida, Ke. Abe, M. O. Wascko, Y. Okajima, H. Nagata, Pablo Fernandez, J. G. Learned, A. Minamino, H. K. Tanaka, T. Yano, Kimihiro Okumura, N. McCauley, C. M. Nantais, J. L. Raaf, K. Martens, K. Huang, A. Kibayashi, S. Mine, K. M. Tsui, J. Gustafson, Lester D.R. Thompson, Shintaro Ito, Yuuki Nakano, F. d. M. Blaszczyk, P. Weatherly, B. Richards, S. Tobayama, Y. M. Zhang, S. Nakayama, A. Takenaka, Hirokazu Ishino, Kate Scholberg, R. Tacik, D. Fukuda, F. Di Lodovico, L. R. Sulak, Yuta Kato, and Science and Technology Facilities Council (STFC)
Subjects: General Physics, Cold dark matter, Dark matter, Physics, Multidisciplinary, General Physics and Astronomy, FOS: Physical sciences, Astrophysics, Electron, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, 7. Clean energy, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), 0103 physical sciences, 010306 general physics, Super-Kamiokande Collaboration, Physics, Annihilation, Science & Technology, 02 Physical Sciences, 010308 nuclear & particles physics, hep-ex, Galactic Center, CONSTRAINTS, hep-ph, Galaxy, GALAXIES, High Energy Physics - Phenomenology, Neutrino detector, 13. Climate action, Physical Sciences, High Energy Physics::Experiment, Super-Kamiokande
Abstract: A search for boosted dark matter using 161.9 kt yr of Super-Kamiokande IV data is presented. We search for an excess of elastically scattered electrons above the atmospheric neutrino background, with a visible energy between 100 MeV and 1 TeV, pointing back to the Galactic center or the Sun. No such excess is observed. Limits on boosted dark matter event rates in multiple angular cones around the Galactic center and Sun are calculated. Limits are also calculated for a baseline model of boosted dark matter produced from cold dark matter annihilation or decay. This is the first experimental search for boosted dark matter from the Galactic center or the Sun interacting in a terrestrial detector.
Published: 2017
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25. Measurement of the tau neutrino cross section in atmospheric neutrino oscillations with Super-Kamiokande

Author: K. Iyogi, W. Y. Ma, K. S. Ganezer, Yuuki Nakano, R. A. Wendell, A. T. Suzuki, J. F. Martin, Takahiro Hiraki, T. Hasegawa, Z. Li, T. Nakadaira, C. Simpson, T. Nakamura, Makoto Sakuda, K. Ito, C. Yanagisawa, J. Amey, L. H. V. Anthony, C. Kachulis, J. Kameda, N. McCauley, C. M. Nantais, Atsushi Takeda, Kimihiro Okumura, J. L. Palomino, P. Mijakowski, K. Huang, B. Quilain, R. Tacik, D. Fukuda, A. Kibayashi, S. Cao, C. Xu, K. Nishijima, Susana Molina Sedgwick, M. O. Wascko, J. L. Raaf, C. Bronner, Lester D.R. Thompson, Y. Hayato, Takaaki Kajita, T. Towstego, M. R. Vagins, T. Tsukamoto, T. Ishii, Yusuke Suda, Masaki Ishitsuka, J. G. Learned, S. Moriyama, C. Vilela, A. Minamino, K. Sakashita, S. Locke, T. Yoshida, G. Santucci, M. Ikeda, Masayuki Nakahata, Y. Uchida, F. d. M. Blaszczyk, T. Yano, C. W. Walter, L. R. Sulak, T. Sekiguchi, Erin O'Sullivan, K. Martens, Y. Nakajima, M. B. Smy, Xiao-yan Li, M. Jiang, K. E. Nakamura, L. Labarga, I. T. Lim, Volodymyr Takhistov, P. Weatherly, B. Richards, Y. Nishimura, M. Murdoch, Yasuhiro Kishimoto, Takashi Kobayashi, K. Frankiewicz, Ll. Marti, M. Murase, M. Koshiba, H. A. Tanaka, Yuta Kato, R. G. Park, T. Ishida, M. J. Wilking, S. N. Smith, H. K. Tanaka, Yoshihiro Suzuki, Makoto Hasegawa, R. Akutsu, R. J. Wilkes, Francesco Muto, A. Cole, J. Y. Kim, Kate Scholberg, Ke. Abe, A. Orii, S. Berkman, M. Miura, Seiko Hirota, J. L. Stone, Hiroyuki Sekiya, Y. Okajima, A. Pritchard, M. Hartz, Soo-Bong Kim, Yuichi Oyama, Y. Fukuda, R. P. Litchfield, S. Nakayama, A. Takenaka, L. Wan, F. Di Lodovico, S. Tobayama, K. Abe, K. Nakamura, M. Kuze, Y. Takeuchi, Shintaro Ito, W. R. Kropp, Y. M. Zhang, T. Hayashino, H. W. Sobel, D. Hamabe, M. Friend, S. Mine, K. M. Tsui, A. Konaka, Yusuke Koshio, H. Nagata, G. Yang, J. Gustafson, Hirokazu Ishino, T. Tomura, Yoshitaka Kuno, H. Okazawa, S. Matsuno, Shigeki Tasaka, M. Elnimr, K. Choi, Pablo Fernandez, J. S. Jang, A. Himmel, R. G. Calland, E. Kearns, Masashi Yokoyama, N. D. Patel, T. Ishizuka, Tsuyoshi Nakaya, C. K. Jung, Masato Shiozawa, Y. Choi, Y. Sonoda, Yoshitaka Itow, G. Pronost, John Hill, D. L. Wark, M. Mori, Song Chen, and Science and Technology Facilities Council (STFC)
Subjects: Particle physics, Physics::Instrumentation and Detectors, Solar neutrino, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astronomy & Astrophysics, 01 natural sciences, Physics, Particles & Fields, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Tau neutrino, 0103 physical sciences, 010306 general physics, Neutrino oscillation, DETECTOR, Charged current, Physics, Science & Technology, hep-ex, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Solar neutrino problem, Physical Sciences, Measurements of neutrino speed, High Energy Physics::Experiment, Neutrino, Super-Kamiokande
Abstract: Using 5326 days of atmospheric neutrino data, a search for atmospheric tau neutrino appearance has been performed in the Super-Kamiokande experiment. Super-Kamiokande measures the tau normalization to be 1.47±0.32 under the assumption of normal neutrino hierarchy, relative to the expectation of unity with neutrino oscillation. The result excludes the hypothesis of no-tau appearance with a significance level of 4.6σ. The inclusive charged-current tau neutrino cross section averaged by the tau neutrino flux at Super-Kamiokande is measured to be (0.94±0.20)×10−38 cm2. The measurement is consistent with the Standard Model prediction, agreeing to within 1.5σ.
Published: 2017
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26. The Dipeptidyl Peptidase-4 Inhibitor Vildagliptin has the Capacity to Repair β-Cell Dysfunction and Insulin Resistance

Author: M. Sunaga, Azuma Kanatsuka, K. Marumo, K. Oshikiri, T. Ishizuka, Y. Suzuki, Yoshiharu Tokuyama, K. Ide, and A. Horie
Subjects: Male, medicine.medical_specialty, Pyrrolidines, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Adamantane, Type 2 diabetes, Dipeptidyl peptidase-4 inhibitor, Biochemistry, Dipeptidyl peptidase, chemistry.chemical_compound, Endocrinology, Insulin resistance, Insulin-Secreting Cells, Internal medicine, Insulin Secretion, Nitriles, medicine, Humans, Insulin, Vildagliptin, Dipeptidyl-Peptidase IV Inhibitors, Glucose tolerance test, medicine.diagnostic_test, business.industry, C-peptide, Biochemistry (medical), Fasting, General Medicine, Glucose Tolerance Test, Middle Aged, medicine.disease, Glucagon-like peptide-1, C-Reactive Protein, chemistry, Area Under Curve, Female, Insulin Resistance, business, medicine.drug
Abstract: The aim of the present study was to determine whether the dipeptidyl peptidase (DPP)-4 inhibitor could repair pancreatic β-cell dysfunction and insulin resistance. Ten subjects with type 2 diabetes who had never received DPP-4 inhibitor treatment were enrolled in the study. Just before and 3 months after twice-daily administration of vildagliptin (50 mg tablets), insulin secretion and insulin sensitivity were estimated using 2-compartment model analysis of C-peptide kinetics and insulin-modified minimal model parameters, respectively. The first-phase insulin secretion (CS1) was determined as the sum of the C-peptide secretion rate (CSR) from 0 to 5 min (normal range 6.8–18.5 ng/ml/min). The whole-body insulin sensitivity index (SI) was calculated using a minimal model software program (normal range 2.6–7.6×10 −4 /min/μU/ml). After vildagliptin treatment, reductions in mean (± SE) HbA1c were noted (43.28±1.53 vs. 40.98±1.77 mmol/mol; p=0.019). Vildagliptin treatment increased the area under the curve for the C peptide reactivity (CPR) (AUC CPR ; 26.66±5.15 vs. 33.02±6.12 ng/ml · 20 min; p=0.003) and CS1 (0.80±0.20 vs. 1.35±0.38 ng/ml/min; p=0.037) in response to an intravenous glucose load. Vildagliptin treatment significantly increased SI (0.46±0.27 vs. 1.21±0.48×10 −4 /min/μU/ml; p=0.037). The long-term administration of vildagliptin improved CS1 and Si suggesting that this drug has the capacity to repair impairments in pancreatic β-cell function and insulin resistance in type 2 diabetes.
Published: 2014

27. Electron Beam Prober for LSI Testing with 100ps Time Resolution.

Author: Y. Goto, K. Ozaki, T. Ishizuka, A. Ito, Y. Furukawa, and T. Inagaki
Published: 1984

28. Search for Neutrinos in Super-Kamiokande associated with Gravitational Wave Events GW150914 and GW151226

Author: Takahiro Hiraki, Y. Totsuka, S. Cao, Hirokazu Ishino, C. Bronner, T. Kayano, C. W. Walter, K. Sakashita, J. G. Learned, Seiko Hirota, J. S. Jang, A. T. Suzuki, T. Tsukamoto, Yoshitaka Itow, C. Xu, H. K. Tanaka, R. J. Wilkes, Takaaki Kajita, T. Ishida, J. F. Martin, J. L. Raaf, M. Goldhaber, Hiroyuki Sekiya, T. Nakadaira, A. Himmel, Yejin Zhang, T. Ishii, Y. Fukuda, L. Wan, Y. Kuno, Makoto Sakuda, R. G. Calland, T. Suzuki, Z. Li, Shigeki Tasaka, Y. Takeuchi, C. Kachulis, V. Takhistov, K. Huang, K. Haga, Atsushi Takeda, S. Mine, A. Kibayashi, C. Yanagisawa, J. L. Palomino, Y. Hayato, B. L. Hartfiel, John Hill, K. Martens, M. Miura, J. Gustafson, L. Labarga, Y. Nishimura, K. Nishijima, T. Kobayashi, A. Konaka, Takehisa Hasegawa, K. Kaneyuki, N. Hong, Tomohiko Nakajima, T. Sekiguchi, Erin O'Sullivan, M. Friend, M. R. Vagins, Kimihiro Okumura, Joshua Hignight, Yusuke Koshio, H. A. Tanaka, T. Tomura, Yasunari Suzuki, K. Iyogi, C. K. Jung, S. Moriyama, R. A. Wendell, Kate Scholberg, G. Santucci, Masayuki Nakahata, H. Okazawa, Takaaki Mori, E. Richard, M. Hartz, Song Chen, I. T. Lim, W. R. Kropp, Masato Shiozawa, Y. Choi, S. Tobayama, M. Jiang, J. L. Stone, Yasuhiro Kishimoto, M. Ikeda, S. Nakayama, L. R. Sulak, T. Yano, K. Nakamura, R. Tacik, D. Fukuda, S. Matsuno, C. Nantais, S. B. Kim, J. Y. Kim, J. Kameda, A. Orii, E. Kearns, Masashi Yokoyama, K. Choi, Pablo Fernandez, P. Mijakowski, N. D. Patel, T. Ishizuka, Tsuyoshi Nakaya, Kazuhiro Suzuki, S. N. Smith, Yusuke Suda, K. S. Ganezer, M. J. Wilking, K. Frankiewicz, T. Nakamura, J. Imber, M. B. Smy, Xiao-yan Li, Ll. Marti, S. Berkman, Yuichi Oyama, A. Minamino, K. Abe, M. Koshiba, R. G. Park, F. d. M. Blaszczyk, P. Weatherly, R. Akutsu, Yuuki Nakano, H. W. Sobel, and UAM. Departamento de Física Teórica
Subjects: Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, 7. Clean energy, 01 natural sciences, Gravitational waves, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Coincident, 0103 physical sciences, GW151226, Neutrinos, 010303 astronomy & astrophysics, Zenith, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Muon, 010308 nuclear & particles physics, Gravitational wave, High Energy Physics::Phenomenology, Física, Astronomy and Astrophysics, 13. Climate action, Space and Planetary Science, High Energy Physics::Experiment, Neutrino, Astroparticle physics, Super-Kamiokande, Astrophysics - High Energy Astrophysical Phenomena, Event (particle physics)
Abstract: Astrophysical Journal Letters 830.1 (2016): L11 reproduced by permission of the AAS, We report the results from a search in Super-Kamiokande for neutrino signals coincident with the first detected gravitational-wave events, GW150914 and GW151226, as well as LVT151012, using a neutrino energy range from 3.5 MeV to 100 PeV. We searched for coincident neutrino events within a time window of ±500 s around the gravitational-wave detection time. Four neutrino candidates are found for GW150914, and no candidates are found for GW151226. The remaining neutrino candidates are consistent with the expected background events. We calculated the 90% confidence level upper limits on the combined neutrino fluence for both gravitational-wave events, which depends on event energy and topologies. Considering the upward-going muon data set (1.6 GeV-100 PeV), the neutrino fluence limit for each gravitational-wave event is 14-37 (19-50) cm-2 for muon neutrinos (muon antineutrinos), depending on the zenith angle of the event. In the other data sets, the combined fluence limits for both gravitational-wave events range from 2.4 ×104 to 7.0 ×109 cm-2, The Super-Kamiokande experiment has been built and operated from funding by the Japanese Ministry of Education, Culture, Sports, Science and Technology, the U.S. Department of Energy, and the U.S. National Science Foundation. Some of us have been supported by funds from the Korean Research Foundation (BK21 and KNRC), the National Research Foundation of Korea (NRF-20110024009), the European Union (H2020 RISE-GA641540-SKPLUS), the Japan Society for the Promotion of Science, the National Natural Science Foundation of China under grant No. 11235006, and the Scinet and Westgrid consortia of Compute Canada
Published: 2016

29. First measurement of radioactive isotope production through cosmic-ray muon spallation in Super-Kamiokande IV

Author: H.A. Tanaka, K. Martens, M. Koshiba, Yuuki Nakano, C. Bronner, W. R. Kropp, S. Tobayama, K. Huang, J. G. Learned, K. Nakamura, Y. Nishimura, P. de Perio, A. Kibayashi, J. S. Jang, A. Himmel, A. L. Renshaw, Y. M. Zhang, A. T. Suzuki, J. F. Martin, C. W. Walter, H. W. Sobel, Y. Hayato, C. K. Jung, Masato Shiozawa, Y. Choi, N. Hong, T. Nakadaira, J. Kameda, Makoto Sakuda, C. Yanagisawa, P. Weatherly, E. Kearns, Masashi Yokoyama, T. Tsukamoto, K. Frankiewicz, J. L. Raaf, Joshua Hignight, T. Ishizuka, Tsuyoshi Nakaya, C. Kachulis, K. Kaneyuki, John Hill, Hiroyuki Sekiya, L. Labarga, A. Minamino, T. Kobayashi, P. Mijakowski, T. Sekiguchi, K. Nishijima, G. Carminati, C. Nantais, S. B. Kim, J. Y. Kim, A. Orii, Y. Fukuda, I. Kametani, K. Choi, Pablo Fernandez, J. L. Palomino, S. Berkman, Kazuhiro Suzuki, Y. Takeuchi, Y. Totsuka, Susumu Takahashi, T. Wongjirad, T. J. Irvine, Shaomin Chen, Yasunari Suzuki, Takaaki Kajita, H. K. Tanaka, Takaaki Mori, M. Miura, B. L. Hartfiel, Atsushi Takeda, Yuichi Oyama, K. Iyogi, S. Nakayama, T. Yano, K. Ieki, Y. Haga, M. Ikeda, Z. Li, M. R. Vagins, T. Ishii, M. J. Wilking, Shigeki Tasaka, R. J. Wilkes, A. Konaka, T. Ishida, M. Friend, J. L. Stone, N. J. Griskevich, E. Richard, R. A. Wendell, K. Abe, Yusuke Koshio, Yoshitaka Itow, R. Tacik, T. Tomura, Kimihiro Okumura, Yusuke Suda, K. Sakashita, I. T. Lim, T. Suzuki, H. Okazawa, S. Moriyama, Masayuki Nakahata, J. Imber, Yasuhiro Kishimoto, M. Goldhaber, K. S. Ganezer, M. B. Smy, Xiao-yan Li, Ll. Marti, Seiko Hirota, T. Kikawa, S. Matsuno, V. Takhistov, T. Kayano, S. N. Smith, Y. Kuno, L. R. Sulak, S. Mine, J. Gustafson, Takehisa Hasegawa, Tomohiko Nakajima, Kate Scholberg, M. Hartz, and Hirokazu Ishino
Subjects: Physics, Particle physics, Physics - Instrumentation and Detectors, Muon, 010308 nuclear & particles physics, Chlorine-36, Order (ring theory), 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Phenomenology, 13. Climate action, 0103 physical sciences, Neutron, Production (computer science), Neutrino, Astrophysics - High Energy Astrophysical Phenomena, 010306 general physics, Super-Kamiokande, Energy (signal processing)
Abstract: Cosmic-ray-muon spallation-induced radioactive isotopes with $\beta$ decays are one of the major backgrounds for solar, reactor, and supernova relic neutrino experiments. Unlike in scintillator, production yields for cosmogenic backgrounds in water have not been exclusively measured before, yet they are becoming more and more important in next generation neutrino experiments designed to search for rare signals. We have analyzed the low-energy trigger data collected at Super-Kamiokande-IV in order to determine the production rates of $^{12}$B, $^{12}$N, $^{16}$N, $^{11}$Be, $^9$Li, $^8$He, $^9$C, $^8$Li, $^8$B and $^{15}$C. These rates were extracted from fits to time differences between parent muons and subsequent daughter $\beta$'s by fixing the known isotope lifetimes. Since $^9$Li can fake an inverse-beta-decay reaction chain via a $\beta + n$ cascade decay, producing an irreducible background with detected energy up to a dozen MeV, a dedicated study is needed for evaluating its impact on future measurements; the application of a neutron tagging technique using correlated triggers was found to improve this $^9$Li measurement. The measured yields were generally found to be comparable with theoretical calculations, except the cases of the isotopes $^8$Li/$^8$B and $^9$Li., Comment: 12 pages, 6 figures, accepted by PRD for publication
Published: 2016

30. Blockade of the K

Author: S, Moriguchi, T, Ishizuka, Y, Yabuki, N, Shioda, Y, Sasaki, H, Tagashira, H, Yawo, J Z, Yeh, H, Sakagami, T, Narahashi, and K, Fukunaga
Subjects: Neurons, Memory Disorders, Potassium Channels, Pyramidal Cells, Long-Term Potentiation, Mice, Transgenic, Dendrites, Hippocampus, Temporal Lobe, Disease Models, Animal, Mice, Alzheimer Disease, Memantine, Memory, Synapses, Animals, Humans, Phosphorylation, Potassium Channels, Inwardly Rectifying, Calcium-Calmodulin-Dependent Protein Kinase Type 2
Abstract: Here, we report a novel target of the drug memantine, ATP-sensitive K
Published: 2015

31. The effect of a stimulus on pelvic floor muscle during voluntary contraction using a facilitating device

Author: Yoshio Suzuki, Atsuko Nakaniida, K. Araki, Atsushi Kubota, T. Ishizuka, and Keishoku Sakuraba
Subjects: Voluntary contraction, business.industry, Medicine, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, Anatomy, Stimulus (physiology), business, Pelvic Floor Muscle
Published: 2017

32. Decreased Interstitial FOXP3+ Lymphocytes in Usual Interstitial Pneumonia with Discrepancy of CXCL12/CXCR4 Axis

Author: S. Tanaka, Masatomo Mori, Katsuaki Endou, Noriko Yanagitani, Akihiro Ono, T. Ishizuka, Takaaki Sano, Kimihiro Shimizu, Mitsuyoshi Utsugi, Y Shimizu, and Kunio Dobashi
Subjects: Adult, Male, Benzylamines, Receptors, CXCR4, Chemokine, Pathology, medicine.medical_specialty, Pulmonary Fibrosis, Immunology, Cyclams, T-Lymphocytes, Regulatory, CXCR4, Idiopathic pulmonary fibrosis, Chemokine receptor, Heterocyclic Compounds, Fibrosis, Usual interstitial pneumonia, Pulmonary fibrosis, medicine, Humans, Immunology and Allergy, IL-2 receptor, Aged, Pharmacology, biology, business.industry, Forkhead Transcription Factors, Middle Aged, respiratory system, medicine.disease, Chemokine CXCL12, Idiopathic Pulmonary Fibrosis, biology.protein, Female, business
Abstract: Regulatory T cells (Treg) play a critical role in immune homeostasis and expansion of Treg is controlled by chemokine receptors. The chemokine CXCL12 and its G-protein-coupled receptor (CXCR4) are involved in the development of idiopathic pulmonary fibrosis (IPF), but the association of Treg with the CXCL12/CXCR4 axis has not been documented. The aim of this study is to determine the distribution and extent of CXCL12/CXCR4 expression in idiopathic type of pulmonary fibrosis, and the relation of Treg expansion in the interstitium of pulmonary fibrosis patients to CXCL12/CXCR4 expression. CXCL12 expression was examined by immunostaining and ELISA in tissue specimens from patients with usual interstitial pneumonia (UIP, n=15), patients with fibrotic non-specific interstitial pneumonia (f-NSIP, n=4), and controls (n=6). CXCR4 expression was examined by in situ hybridization and immunoblotting. Expression of CD45, CD3, CD20, transcription factor forkhead box P3 (FOXP3), and CD25 was assessed by immunostaining. Fibrosis was evaluated by determining the established fibrosis (EF) score. The CXCL12/CXCR4 axis was upregulated in UIP and f-NSIP, and CXCL12 derived from lung tissue attracted CXCR4+ cells. CXCR4+ cells showed a CD3+ cell distribution pattern. The interstitial FOXP3+/CD3+ and CD25+/CD3+ cell ratios were lower in UIP than f-NSIP, but the CXCR4+/ CD3+ cell ratio was not different. The FOXP3+/CD3+ cell ratio and EF score were inversely correlated. These findings suggest that the CXCL12/CXCR4 axis contributes to inflammation in UIP and f-NSIP by promoting the accumulation CXCR4+ lymphocytes, and a decrease of Treg is correlated with the severity of fibrosis in UIP.
Published: 2010

33. Clinicopathological and Therapeutic Significance of CXCL12 Expression in Lung Cancer

Author: Tetsunari Oyama, Hisao Imai, Masatomo Mori, Seiichi Kakegawa, Yasuo Shimizu, John D. Minna, T. Ishizuka, Takaaki Sano, Noriaki Sunaga, Ryusei Saito, and Kimihiro Shimizu
Subjects: Male, Receptors, CXCR4, Pathology, medicine.medical_specialty, Lung Neoplasms, Immunology, Cell, CXCR4, Article, Metastasis, Cell Movement, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, medicine, Carcinoma, Humans, Immunology and Allergy, RNA, Messenger, RNA, Small Interfering, Lung cancer, Cell Proliferation, Receptors, CXCR, Pharmacology, Lung, business.industry, Cell growth, respiratory system, medicine.disease, Chemokine CXCL12, biological factors, respiratory tract diseases, ErbB Receptors, medicine.anatomical_structure, embryonic structures, Adenocarcinoma, Female, biological phenomena, cell phenomena, and immunity, business
Abstract: Interactions between CXCL12 and its receptors CXCR4 or CXCR7 are involved in tumor growth and metastasis in various types of human cancer. However, CXCL12 expression and its role in lung cancer are not fully elucidated. Here we examined the expression of CXCL12 in 54 lung cancer cell lines consisting of 23 small cell lung cancers (SCLCs) and 31 non-small cell lung cancers (NSCLCs). CXCL12 was overexpressed in lung cancer cell lines compared to non-malignant human bronchial epithelial cell lines (N = 6). CXCL12 expression was positively but weakly correlated with the expression of CXCR4 or CXCR7. We also examined CXCL12 expression in 89 NSCLC specimens and found that CXCL12 expression was significantly higher in tumor specimens from female patients, non-smokers and adenocarcinoma patients. Small interfering RNAs targeting CXCL12 inhibited cellular proliferation, colony formation and migration of CXCL12-overexpressing lung cancer cells; however, this inhibition did not occur in lung cancer cells that lacked CXCL12. Furthermore, the anti-CXCL12 neutralizing antibody mediated inhibitory effects in three lung cancer cell lines that overexpressed CXCL12, but not in two CXCL12 non-expressing lung cancer cell lines nor two non-malignant bronchial epithelial cell lines. The present study demonstrates that: CXCL12 is concomitantly overexpressed with CXCR4 or CXCR7 in lung cancers; CXCL12 is highly expressed in NSCLCs from females, non-smokers and adenocarcinoma patients; and disruption of CXCL12 inhibits the growth and migration of lung cancer cells. Our findings indicate that CXCL12 is required for tumor growth and provide a rationale for the anti-CXCL12 treatment strategy in lung cancer.
Published: 2010

34. Experimental evaluation of photocrosslinkable chitosan hydrogel as injection solution for endoscopic resection

Author: T. Ishizuka, Yoshihiro Tanaka, Satoshi Aiko, S. Nakamura, Satoko Kishimoto, Hidemi Hattori, Masayuki Ishihara, Takuya Horio, Tadaaki Maehara, Yashiro Nogami, and Yasuhiro Kanatani
Subjects: Male, medicine.medical_specialty, Swine, medicine.medical_treatment, Perforation (oil well), Biocompatible Materials, Sodium Chloride, Injections, Chitosan, chemistry.chemical_compound, medicine, Animals, Endoscopic resection, Intestinal Mucosa, Saline, Wound Healing, business.industry, Dissection, Biocompatibility Testing, Gastroenterology, Endoscopy, Hydrogels, Injection solution, Surgery, Hypertonic saline, Cross-Linking Reagents, Treatment Outcome, chemistry, Models, Animal, Feasibility Studies, business, Wound healing
Abstract: BACKGROUND AND STUDY AIMS: Saline as an injection solution for endoscopic resection techniques has several disadvantages such as a short-lasting effect leading to a potentially higher risk of bleeding and perforation. The new substance of photocrosslinkable chitosan hydrogel in a DMEM/F12 medium (PCH) can be converted into an insoluble hydrogel by ultraviolet irradiation for 30 s, and was evaluated in two sets of animal experiments. METHODS: 18 pigs were used in the two parts of the study. First, mucosal resections were done with either PCH or hypertonic saline; the effects of both agents on wound healing were examined endoscopically and histologically. Second, in vivo degradation of PCH was examined using six pig stomachs. RESULT: PCH injection led to a longer-lasting elevation with clearer margins, compared with hypertonic saline, thus enabling precise endoscopic submucosal dissection (ESD) along the margins of the elevated mucosa. The endoscopic appearance after ESD was similar in both groups. PCH biodegradation was completed within 8 weeks according to endoscopic and histologic analyses. CONCLUSION: PCH is a promising agent for submucosal injection prior to various techniques of endoresection. It should be evaluated in clinical trials after biocompatibility testing for PCH is completed.
Published: 2009

35. Enteral immuno-enhanced diets with arginine are safe and beneficial for patients early after esophageal cancer surgery

Author: Tadaaki Maehara, Norishige Kanai, T. Ishizuka, Takuya Horio, Takashi Sakano, Yutaka Yoshizumi, Satoshi Aiko, and Isao Kumano
Subjects: Male, medicine.medical_specialty, Esophageal Neoplasms, Platelet Aggregation, Arginine, Enteral administration, Enteral Nutrition, Fatty Acids, Omega-3, Humans, Medicine, Platelet, Radical surgery, Adverse effect, Omega 3 fatty acid, Blood Coagulation, Aged, Food, Formulated, Postoperative Care, business.industry, Gastroenterology, General Medicine, Middle Aged, Esophageal cancer, medicine.disease, Systemic Inflammatory Response Syndrome, Surgery, Parenteral nutrition, RNA, Female, business, Immunocompetence
Abstract: We previously reported that provision of immediate enteral nutrition (EN) with a certain amount of omega (omega)-3 fatty acids (FAs) in patients after esophageal cancer surgery resulted in reduced platelet aggregation, coagulation activity, and cytokine production. We investigated whether EN using immuno-enhanced diet (IED) containing a large amount of omega-3 FAs as well as arginine and RNA affected the above-described responses. We also attempted to reveal whether arginine in the IED can potentially harm patients who undergo esophageal cancer surgery. Twenty-nine patients with esophageal cancer who underwent similar surgical procedures were selected. All patients received EN starting immediately after surgery. Fourteen patients received the formula with fewer omega-3 FAs, and fifteen patients received the IED. Administration of the IED tended to inhibit postoperative decrease in platelet count. Prothrombin activity and thrombin-antithrombin III complex levels were significantly reduced in the IED group. Plasma IL-8 levels were significantly lower (P < 0.05) in patients without the IED on the fifth postoperative day (POD). The proportion of T-cells was significantly higher (P < 0.05) in the IED group on PODs 1 and 7. Nitrate/nitrite levels did not differ significantly between the two groups. Early EN with an IED may enhance the inhibitory effects on postoperative platelet aggregation and hypercoagulation, and appeared to be advantageous to T-cell proliferation. These effects are expected to be beneficial in patients at risk of developing infectious complications. This study also showed that the IED could be safely used without any adverse effects for patients early after a radical surgery for the esophageal cancer.
Published: 2008

36. Surgical attempts to avoid anastomotic leaks and reduce reflux esophagitis following esophagectomy for cancer

Author: Takefumi Nakayama, Hitoshi Ogawa, Takuya Horio, Tadaaki Maehara, T. Ishizuka, Norishige Kanai, Yutaka Yoshizumi, and Satoshi Aiko
Subjects: medicine.medical_specialty, integumentary system, business.industry, medicine.medical_treatment, fungi, Gastroenterology, Cancer, equipment and supplies, medicine.disease, Surgery, Surgical oncology, Esophagectomy, Cardiothoracic surgery, Anastomotic leaks, medicine, Reflux esophagitis, business
Abstract: Background We analyzed the results of our surgical attempts to establish a safe reconstruction after esophagectomy for cancer that withstands both early and subsequent complications.
Published: 2008

37. Study of TeV neutrinos with upward showering muons in Super-Kamiokande

Author: C. W. Walter, R. Wendell, R. Svoboda, T. Ishizuka, S. Yamada, T. Sasaki, M. Yoshida, H. G. Berns, M. B. Smy, Y. Furuse, K. Kaneyuki, C. Saji, Masashi Yokoyama, R. Terri, A. Minamino, J. Dunmore, Takaaki Kajita, Y. Totsuka, K. Iida, M. Koshiba, Y. Oyama, B. S. Yang, Y. Choi, K. Ishihara, T. J. Haines, T. Sato, D. W. Liu, Haruki Watanabe, Masato Shiozawa, N. Tamura, H. Nishino, I. Kato, Lawrence Sulak, J. L. Raaf, J. L. Stone, S. Mine, Y. Takeuchi, Atsushi Takeda, E. Kearns, S. T. Clark, C. Ishihara, Shantanu Desai, Kunio Inoue, M. Sugihara, H. Ishii, C. K. Jung, T. Ishida, M. Swanson, K. Abe, T. Kobayashi, K. Nishikawa, T. Nakaya, T. Nakadaira, Yusuke Koshio, K. Nitta, J. Yoo, S. Yamamoto, Kate Scholberg, J. Y. Kim, C. McGrew, M. R. Vagins, C. Yanagisawa, K. Kobayashi, Y. Obayashi, K. Washburn, W. E. Keig, M. Hasegawa, Shigetaka Moriyama, S. Likhoded, G. Mitsuka, K. Ueshima, I. S. Jeong, M. Sakuda, Y. Hayato, R. Gran, T. Hasegawa, F. Dufour, I. T. Lim, H. K. Seo, A. K. Ichikawa, J. S. Jang, T. Tanaka, D. Kielczewska, Y. Kuno, K. Nishijima, S. Nakayama, M. Ishitsuka, N. Tanimoto, S. Tasaka, H. Okazawa, R. J. Wilkes, W. Wang, Masayuki Nakahata, Alec Habig, T. Koike, B. Hartfiel, Y. Takenaga, K. Okumura, Y. Fukuda, Y. Idehara, K. S. Ganezer, M. Miura, Hirokazu Ishino, M. D. Messier, C. Regis, J. Kameda, Katsuki Hiraide, S. Dazeley, J. P. Cravens, T. Ishii, H. Sato, Y. Gando, J. Hill, Yasunari Suzuki, S. Matsuno, G. Guillian, A. T. Suzuki, H. W. Sobel, Eric Thrane, M. Fechner, Y. Watanabe, W. R. Kropp, S. B. Kim, A. Clough, David William Casper, C. Mitsuda, H. Ogawa, K. K. Shiraishi, I. Higuchi, J. G. Learned, H. Maesaka, M. Goldhaber, T. Kato, Yoshitaka Itow, S. Hatakeyama, K. Nakamura, and A. Sarrat
Subjects: Physics, Muon, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Bremsstrahlung, Astronomy and Astrophysics, High Energy Physics - Experiment, Nuclear physics, Pair production, WIMP, High Energy Physics::Experiment, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Super-Kamiokande, Neutrino oscillation, Zenith
Abstract: A subset of neutrino-induced upward through-going muons in the Super-Kamiokande detector consists of high energy muons which lose energy through radiative processes such as bremsstrahlung, e^{+} e^{-} pair production and photonuclear interactions. These ``upward showering muons'' comprise an event sample whose mean parent neutrino energy is approximately 1 TeV. We show that the zenith angle distribution of upward showering muons is consistent with negligible distortion due to neutrino oscillations, as expected of such a high-energy neutrino sample. We present astronomical searches using these high energy events, such as those from WIMP annihilations in the Sun, Earth and Galactic Center, some suspected point sources, as well as searches for diffuse flux from the interstellar medium., Comment: Submitted for publication to Astroparticle Physics. Fig 12 has slightly higher resolution in the version submitted to the journal
Published: 2008

38. Acute Impact of Volcanic Ash on Asthma Symptoms and Treatment

Author: Yasuo Shimizu, Munemasa Mori, Takeshi Hisada, Makoto Todokoro, H Iijima, T. Ishizuka, Akihiro Ono, Kunio Dobashi, Seiichi Kakegawa, Kunihiko Iizuka, Mitsuyoshi Utsugi, and Akihiro Morikawa
Subjects: Adult, Male, medicine.medical_specialty, Cross-sectional study, Immunology, Peak Expiratory Flow Rate, Volcanic Eruptions, 03 medical and health sciences, 0302 clinical medicine, Japan, immune system diseases, Surveys and Questionnaires, Wheeze, medicine, Humans, Immunology and Allergy, Aged, Asthma, Pharmacology, Inhalation, business.industry, Asthma symptoms, Middle Aged, medicine.disease, respiratory tract diseases, Cross-Sectional Studies, 030220 oncology & carcinogenesis, Emergency medicine, Female, medicine.symptom, business, Airway, Disaster medicine, 030215 immunology, Volcanic ash
Abstract: Information about the impacts of disasters on health is useful for establishing hazard prediction maps and action plans of disaster management. This study aims at learning effective asthma management from the volcano disaster of Mount Asama eruption in Japan on September 1, 2004. We conducted a cross-sectional study to assess the acute impact of volcanic ash on asthma symptoms and their treatment changes by using a questionnaire completed by 236 adult asthmatic patients and their physicians. In the ashfall over 100g/m2 area, 42.9% of asthma patients suffered exacerbations, PEF decreased, asthma treatments increased, and inhalation of β2 stimulants was used most for exacerbated asthma. Compared to severe asthma patients, mild and moderate asthma patients were most at risk. Severe asthma patients were not affected since most of them knew their asthma status was severe, and did not go outside and kept windows closed. Deteriorated asthma symptoms of wheezing, chest tightness and cough appeared in the ashfall over 100g/m2 area. Ash contained inhalable 10μm diameter particles, and included high concentrations of airway toxic substrates of silica. These data suggest that ashfall over 100 g/m2 is harmful, access to these areas by asthma patients needs to be restricted, and these areas need to improve asthma treatment. In addition, the increase in the proportion of asthma patients with wheeze and cough are diagnostic clues for ash-induced asthma in affected areas, and can be used by doctors to tell whether patients are receiving sufficient asthma treatment.
Published: 2007

39. Search for Neutrinos from Annihilation of Captured Low-Mass Dark Matter Particles in the Sun by Super-Kamiokande

Author: K. Iyogi, R. A. Wendell, A. T. Suzuki, J. F. Martin, Y. Kuno, K. Kaneyuki, Atsushi Takeda, T. Sekiguchi, S. Berkman, A. Minamino, T. Nakadaira, Y. Takeuchi, John Hill, K. Ieki, Hirokazu Ishino, Makoto Sakuda, J. L. Raaf, Yasunari Suzuki, J. G. Learned, K. Choi, R. J. Wilkes, Kimihiro Okumura, K. S. Ganezer, S. N. Smith, Seiko Hirota, M. Miura, I. Kametani, T. Kikawa, E. Kearns, T. Tsukamoto, C. W. Walter, L. Labarga, K. Sakashita, T. Kobayashi, Yasuhiro Kishimoto, K. Nakamura, Takaaki Kajita, M. Koshiba, S. Matsuno, Masashi Yokoyama, Shigeki Tasaka, Takaaki Mori, M. Goldhaber, J. L. Stone, Y. Hayato, Yejin Zhang, S. Moriyama, C. Yanagisawa, T. Ishida, R. Tacik, Masayuki Nakahata, Yoshinori Haga, Hiroyuki Sekiya, K. Martens, K. Huang, T. Tomura, A. Kibayashi, T. Ishizuka, J. Kameda, S. Mine, Yoshitaka Itow, H. Okazawa, A. Konaka, Tsuyoshi Nakaya, Y. Fukuda, K. P. Lee, P. Mijakowski, T. J. Irvine, C. K. Jung, J. Imber, H.A. Tanaka, T. McLachlan, M. Ikeda, K. Nishijima, T. Akiri, M. J. Wilking, Kazuhiro Suzuki, Masato Shiozawa, Y. Choi, Song Chen, T. Hasegawa, M. R. Vagins, Yusuke Koshio, C. Bronner, Kate Scholberg, G. Mitsuka, S. Nakayama, T. Ishii, I. T. Lim, J. S. Jang, H. W. Sobel, W. R. Kropp, S. Tobayama, A. Himmel, Yuuki Nakano, S. B. Kim, J. Y. Kim, L. R. Sulak, M. B. Smy, P. de Perio, T. Yano, A. L. Renshaw, Yuichi Oyama, K. Abe, Y. Nishimura, N. Hong, Joshua Hignight, Y. Totsuka, Susumu Takahashi, T. Wongjirad, Ll. Marti, G. Carminati, and UAM. Departamento de Física Teórica
Subjects: Physics, Particle physics, Atmospheric neutrinos, Annihilation, Muon, Physics::Instrumentation and Detectors, Dark matter, General Physics and Astronomy, Física, Surrounding rock, Coupling (probability), Elastic scattering cross sections, Low mass, Upper limits, Nuclear physics, Weakly interacting massive particles, WIMP, Dark matter particles, High Energy Physics::Experiment, Neutrino, Super-Kamiokande
Abstract: Artículo escrito por muchos autores, sólo se referencian el primero, los autores que firman como Universidad Autónoma de Madrid y el grupo de colaboración en el caso de que aparezca en el artículo, Super-Kamiokande (SK) can search for weakly interacting massive particles (WIMPs) by detecting neutrinos produced from WIMP annihilations occurring inside the Sun. In this analysis, we include neutrino events with interaction vertices in the detector in addition to upward-going muons produced in the surrounding rock. Compared to the previous result, which used the upward-going muons only, the signal acceptances for light (few-GeV/c2-200-GeV/c2) WIMPs are significantly increased. We fit 3903 days of SK data to search for the contribution of neutrinos from WIMP annihilation in the Sun. We found no significant excess over expected atmospheric-neutrino background and the result is interpreted in terms of upper limits on WIMP-nucleon elastic scattering cross sections under different assumptions about the annihilation channel. We set the current best limits on the spin-dependent WIMP-proton cross section for WIMP masses below 200 GeV/c2 (at 10 GeV/c2, 1.49×10-39 cm2 for χχ→bb¯ and 1.31×10-40 cm2 for χχ→τ+τ- annihilation channels), also ruling out some fraction of WIMP candidates with spin-independent coupling in the few-GeV/c2 mass range, The Super-Kamiokande experiment was built and has been operated with funding from the Japanese Ministry of Education, Culture, Sports, Science and Technology, the U.S. Department of Energy, and the U.S. National Science Foundation
Published: 2015

40. Test of Lorentz invariance with atmospheric neutrinos

Author: Susumu Takahashi, T. Wongjirad, H. Okazawa, C. K. Jung, Yuichi Oyama, K. Ieki, T. Ishii, K. Sakashita, Masato Shiozawa, Y. Choi, R. J. Wilkes, R. Yamaguchi, K. Abe, Hirokazu Ishino, M. Ikeda, T. J. Irvine, J. Kameda, P. Fernandez, P. Mijakowski, Kazuhiro Suzuki, K. Martens, Y. Nishimura, M. Goldhaber, Yejin Zhang, S. Matsuno, K. Iyogi, J. S. Jang, S. Moriyama, S. B. Kim, J. Y. Kim, M. Koshiba, Y. Takeuchi, C. Yanagisawa, N. Hong, A. Himmel, Masayuki Nakahata, K. P. Lee, Lawrence Sulak, Atsushi Takeda, Joshua Hignight, Yoshihiro Suzuki, Takaaki Mori, J. L. Stone, A. T. Suzuki, K. Kaneyuki, T. Sekiguchi, K. Nishijima, Kate Scholberg, J. F. Martin, T. Nakadaira, Shigeki Tasaka, A. Konaka, B. L. Hartfiel, John Hill, S. Mine, Makoto Sakuda, J. Gustafson, E. Kearns, Yusuke Suda, Masashi Yokoyama, P. de Perio, T. Yano, A. L. Renshaw, Takehisa Hasegawa, Yusuke Koshio, Kimihiro Okumura, C. W. Walter, S. N. Smith, T. Ishizuka, J. Imber, M. Miura, Tsuyoshi Nakaya, W. E. Keig, M. B. Smy, T. Akiri, G. Carminati, K. Tateishi, Y. Haga, Hiroyuki Sekiya, K. Choi, Ll. Marti, L. Labarga, T. Kobayashi, Yoshitaka Itow, Seiko Hirota, T. Kikawa, Y. Fukuda, Y. Kuno, S. Berkman, J. G. Learned, T. McLachlan, E. Richard, P. Weatherly, Takaaki Kajita, K. Connolly, A. Minamino, Yasuhiro Kishimoto, Y. Hayato, R. A. Wendell, Song Chen, H. K. Tanaka, Yuuki Nakano, H.A. Tanaka, V. Takhistov, H. W. Sobel, C. Bronner, M. R. Vagins, I. Kametani, R. Tacik, A. Murakami, G. Mitsuka, I. T. Lim, K. Huang, S. Nakayama, K. S. Ganezer, A. Kibayashi, T. Tsukamoto, T. Ishida, T. Yokozawa, W. R. Kropp, S. Tobayama, K. Nakamura, J. L. Raaf, M. J. Wilking, Koh Ueno, Y. Totsuka, T. Tomura, and UAM. Departamento de Física Teórica
Subjects: Physics, Nuclear and High Energy Physics, Particle physics, 010308 nuclear & particles physics, Lorentz transformation, High Energy Physics::Phenomenology, Isotropy, FOS: Physical sciences, Física, Lorentz covariance, 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), symbols.namesake, Orders of magnitude (time), Standard-Model Extension, 0103 physical sciences, Range (statistics), symbols, High Energy Physics::Experiment, Neutrino, 010306 general physics, Neutrino oscillation
Abstract: Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM, A search for neutrino oscillations induced by Lorentz violation has been performed using 4,438 live-days of Super-Kamiokande atmospheric neutrino data. The Lorentz violation is included in addition to standard three-flavor oscillations using the nonperturbative standard model extension (SME), allowing the use of the full range of neutrino path lengths, ranging from 15 to 12,800 km, and energies ranging from 100 MeV to more than 100 TeV in the search. No evidence of Lorentz violation was observed, so limits are set on the renormalizable isotropic SME coefficients in the eμ, μτ, and eτ sectors, improving the existing limits by up to 7 orders of magnitude and setting limits for the first time in the neutrino μτ sector of the SME, We would like to thank A. Kostelecky for his advice and support and we are grateful to J. S. Diaz for working closely with us to calculate and implement the Lorentz-violating oscillation probabilities. The authors gratefully acknowledge the cooperation of the Kamioka Mining and Smelting Company. Super-K has been built and operated from funds provided by the Japanese Ministry of Education, Culture, Sports, Science and Technology, the U.S. Department of Energy, and the U.S. National Science Foundation. This work was partially supported by the Research Foundation of Korea (BK21 and KNRC), the Korean Ministry of Science and Technology, the National Science Foundation of China, the European Union FP7 (DS laguna-lbno PN- 284518 and ITN invisibles GA-2011-289442), the National Science and Engineering Research Council (NSERC) of Canada, and the Scinet and Westgrid consortia of Compute Canada
Published: 2015

41. Search for Nucleon and Dinucleon Decays with an Invisible Particle and a Charged Lepton in the Final State at the Super-Kamiokande Experiment

Author: K. Kaneyuki, K. Sakashita, K. Nakamura, T. Sekiguchi, M. Goldhaber, I. Kametani, C. K. Jung, W. R. Kropp, S. Tobayama, S. Moriyama, Yejin Zhang, T. J. Irvine, T. Ishii, R. A. Wendell, T. Tomura, Masayuki Nakahata, Yusuke Suda, Masato Shiozawa, Y. Choi, Y. Totsuka, Song Chen, Susumu Takahashi, M. Hartz, T. Wongjirad, R. Tacik, H. Okazawa, Atsushi Takeda, M. Ikeda, J. Imber, K. Ieki, A. T. Suzuki, T. Tsukamoto, J. L. Raaf, R. J. Wilkes, J. F. Martin, M. B. Smy, Xiao-yan Li, T. Nakadaira, C. W. Walter, T. Ishida, E. Richard, E. Kearns, C. Yanagisawa, Makoto Sakuda, Masashi Yokoyama, B. L. Hartfiel, Ll. Marti, Seiko Hirota, M. J. Wilking, T. Kikawa, K. Nishijima, C. Kachulis, T. Ishizuka, Y. Nishimura, L. R. Sulak, Kimihiro Okumura, Yuichi Oyama, Tsuyoshi Nakaya, Shigeki Tasaka, V. Takhistov, J. S. Jang, Hiroyuki Sekiya, N. Hong, J. L. Palomino, A. Himmel, T. Kayano, Yasuhiro Kishimoto, Joshua Hignight, Yoshihiro Suzuki, Y. Fukuda, K. Abe, L. Labarga, T. Kobayashi, A. Konaka, S. Berkman, Y. Kuno, Y. Takeuchi, P. de Perio, T. Hasegawa, A. L. Renshaw, K. Choi, Pablo Fernandez, K. Iyogi, Yusuke Koshio, K. Frankiewicz, M. Friend, T. Suzuki, Takaaki Kajita, C. Nantais, S. B. Kim, J. Y. Kim, A. Orii, H. W. Sobel, John Hill, K. Huang, A. Kibayashi, M. R. Vagins, I. T. Lim, J. G. Learned, H. K. Tanaka, Yoshitaka Itow, Takaaki Mori, J. L. Stone, Yuuki Nakano, M. Miura, K. S. Ganezer, H.A. Tanaka, G. Carminati, Y. Haga, S. N. Smith, P. Weatherly, C. Bronner, S. Nakayama, T. Yano, K. Martens, A. Minamino, S. Mine, M. Koshiba, S. Matsuno, J. Gustafson, J. Kameda, Hirokazu Ishino, P. Mijakowski, Z. Li, Kazuhiro Suzuki, Tomohiko Nakajima, Y. Hayato, Kate Scholberg, and UAM. Departamento de Física Teórica
Subjects: Physics, Particle physics, High Energy Physics::Phenomenology, Confidence levels, General Physics and Astronomy, Nucleon decays, Física, FOS: Physical sciences, State (functional analysis), Super-Kamiokande experiment, Invisible particle, High Energy Physics - Experiment, Nuclear physics, Massless particle, High Energy Physics - Phenomenology, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), Bound state, Particle, High Energy Physics::Experiment, Nucleon, Super-Kamiokande, Lepton
Abstract: Artículo escrito por muchos autores, sólo se referencian el primero, los autores que firman como Universidad Autónoma de Madrid y el grupo de colaboración en el caso de que aparezca en el artículo, Search results for nucleon decays p→e+X, p→μ+X, n→νγ (where X is an invisible, massless particle) as well as dinucleon decays np→e+ν, np→μ+ν, and np→τ+ν in the Super-Kamiokande experiment are presented. Using single-ring data from an exposure of 273.4 kton·yr, a search for these decays yields a result consistent with no signal. Accordingly, lower limits on the partial lifetimes of τp→e+X>7.9×1032yr, τp→μ+X>4.1×1032yr, τn→νγ>5.5×1032yr, τnp→e+ν>2.6×1032yr, τnp→μ+ν>2.2×1032yr, and τnp→τ+ν>2.9×1031yr at a 90% confidence level are obtained. Some of these searches are novel, The Super- Kamiokande experiment was built and has been operated with funding from the Japanese Ministry of Education, Culture, Sports, Science and Technology, the U.S. Department of Energy, and the U.S. National Science Foundation
Published: 2015
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42. Gemcitabine-based regimen for primary ovarian angiosarcoma with MYC amplification

Author: S. Tajima, T. Ishizuka, R. Onoda, M. Narushima, Michihiko Waki, Y. Tamura, and I. Yonezawa
Subjects: Chemotherapy, Pathology, medicine.medical_specialty, business.industry, medicine.medical_treatment, Ovarian Angiosarcoma, gemcitabine, Case Report, surgical resection, MYC, Primary Angiosarcoma, medicine.disease, chemotherapy, Gemcitabine, Regimen, MYC Gene Amplification, Cancer research, medicine, Angiosarcoma, Sarcoma, business, medicine.drug, mucinous cystadenoma
Abstract: Angiosarcoma is a rare and aggressive type of sarcoma, and primary angiosarcoma of the ovary is extremely rare. We report the case of a 29-year-old woman who was diagnosed with ovarian angiosarcoma and possible bone metastases. We treated this patient with a gemcitabine-based regimen as postoperative adjuvant chemotherapy, after which she achieved at least 7 years of progression-free survival, an extremely long duration given the aggressive features of this tumour. We retrospectively performed immunohistochemical analyses and fluorescence in situ hybridization to make a pathology diagnosis and to investigate the tumour features. MYC amplification and c-Myc protein overexpression were positively detected. It might be possible to correlate the effectiveness of the gemcitabine-based chemotherapeutic regimen with MYC gene amplification and c-Myc protein overexpression.
Published: 2014
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43. Acceleration of wound healing in healing-impaired db/db mice with a photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2

Author: Kiyohaya Obara, T. Ishizuka, Susumu Tominaga, Masayuki Ishihara, Masanori Fujita, Yasuhiro Kanatani, Sadayuki Hiroi, Takemi Matsui, Hidemi Hattori, Tadaaki Maehara, Yuichi Ozeki, Shingo Nakamura, Bonpei Takase, and Toshiaki Kawai
Subjects: medicine.medical_specialty, Contraction (grammar), Administration, Topical, macromolecular substances, Dermatology, Fibroblast growth factor, complex mixtures, Hydrogel, Polyethylene Glycol Dimethacrylate, Diabetes Complications, Chitosan, Mice, Filling rate, chemistry.chemical_compound, In vivo, medicine, Ultraviolet light, Animals, Fibroblast, Wound Healing, Chemistry, technology, industry, and agriculture, Surgery, medicine.anatomical_structure, Models, Animal, Wounds and Injuries, Fibroblast Growth Factor 2, Wound healing, Biomedical engineering
Abstract: Application of ultraviolet light irradiation to a photocrosslinkable chitosan (Az-CH-LA) aqueous solution including fibroblast growth factor-2 (FGF-2) results within 30 seconds in an insoluble, flexible hydrogel. The FGF-2 molecules retained in the chitosan hydrogel remain biologically active and are released from the chitosan hydrogel upon in vivo biodegradation of the hydrogel. To evaluate the accelerating effect on wound healing of this hydrogel, full-thickness skin incisions were made in the backs of healing-impaired diabetic (db/db) mice and their normal (db/+) littermates. The mice were later killed, and histological sections of the wound were prepared. The degree of wound healing was evaluated using several histological parameters such as the rate of contraction, epithelialization, and tissue filling. Application of the chitosan hydrogel significantly advanced the rate of contraction on Days 0 to 2 in db/db and db/+ mice. Although the addition of FGF-2 into the chitosan hydrogel in db/+ mice had little effect, application of the chitosan hydrogel-containing FGF-2 further accelerated the adjusted tissue filling rate (Days 2 to 4 and Days 4 to 8) in db/db mice. Furthermore, the chitosan hydrogel-containing FGF-2 markedly increased the number of CD-34-positive vessels in the wound areas of db/db mice on Day 4. Thus, the application of chitosan hydrogel-containing FGF-2 onto a healing-impaired wound induces significant wound contraction and accelerates wound closure and healing.
Published: 2005

44. A new method to detect systemic inflammatory response syndrome by continuous monitoring system: an experimental study in rats

Author: Makoto Kikuchi, Minoru Suzuki, Takemi Matsui, Masayuki Ishihara, Akira Kurita, and T. Ishizuka
Subjects: Male, Lipopolysaccharide, Biomedical Engineering, Body Temperature, Rats, Sprague-Dawley, Electrocardiography, chemistry.chemical_compound, Heart Rate, medicine, Animals, Diagnosis, Computer-Assisted, Respiratory system, Monitoring, Physiologic, Deep body temperature, business.industry, Spectrum Analysis, Continuous monitoring, Monitoring system, Equipment Design, General Medicine, medicine.disease, Systemic Inflammatory Response Syndrome, Rats, Equipment Failure Analysis, Systems Integration, Systemic inflammatory response syndrome, chemistry, Thermography, Anesthesia, Immunology, Respiratory Mechanics, business, Temperature mapping
Abstract: A continuous monitoring system was designed for detection of systemic inflammatory response syndrome (SIRS) using spectrum analyser and local temperature mapping system with deep body thermometer. This method demonstrated significant increases of heart and respiratory rates and deep body temperature from normal levels within 120 minutes after lipopolysaccharide administration in rats. Our monitoring system appears promising for clinical detection of SIRS in the early stages to prevent multiple organ failure.
Published: 2005

45. Clinical Analysis of the Surgical Indication after Neoadjuvant Chemoradiotherapy for the Advanced Esophageal Cancer

Author: Shinichi Tsuwano, T. Ishizuka, Tomokazu Matsuyama, Yoshiaki Sugiura, Tadaaki Maehara, Satoshi Aiko, and Yutaka Yoshizumi
Subjects: Oncology, medicine.medical_specialty, Clinical pathology, business.industry, Internal medicine, Gastroenterology, medicine, Advanced esophageal cancer, Surgery, business, Neoadjuvant chemoradiotherapy
Abstract: はじめに: 進行食道癌の予後改善を目的に術前化学放射線療法 (CRT) が行われているが, その後の手術適応について判断に迷う例も少なくない. そこでCRT後の手術の安全性と手術例の予後規定因子より手術適応の明確化を試みた. 対象・方法: 1989年以降の当科入院食道癌患者のうちCRT後の切除例28例をCRT手術群, 術前無治療の切除例194例を対照手術群とした. CRT手術群と対照手術群で手術侵襲, 周術期免疫能, 在院死・合併症の頻度, 在院日数を比較した. CRT手術群の予後規定因子として有意な影響を示す因子から, 比例ハザードモデルにより独立した予後規定因子を求めた. 結果: CRT手術群はUt症例, 3領域郭清例を多く含み, 対照手術群に比べて手術時間・出血量ともに多く, 末梢血リンパ球数は9PODまで, リンパ球幼若化反応は1PODで低値を示した. 縫合不全の発生率, 在院死の頻度が有意に高かったが, 他の合併症・手術関連死の頻度, 術後在院日数に差はなかった. CRT手術群では, 手術的根治度と組織学的深達度が独立した予後規定因子となり, 対照手術群と異なる特徴を示した. 考察: CRT後の手術は, 侵襲が増大し免疫能の低下した条件下で行われるが, 安全性は許容範囲内と考えた. 早期再燃による在院死が多く, 予後規定因子である根治度Aの手術が可能な症例にのみ手術を行うべきである.
Published: 2004

46. Biomedical engineering's contribution to defending the homeland

Author: T. Ishizuka, S. Sato, Hiroshi Ashida, Masayuki Ishihara, Makoto Kikuchi, Takemi Matsui, and H. Wakisaka
Subjects: Telemedicine, Injury control, business.industry, Biomedical Engineering, Civil Defense, Poison control, Homeland, General Medicine, Computer security, computer.software_genre, Bioterrorism, Security Measures, Microwave radar, Optical imaging, Equipment and Supplies, Japan, Biological warfare, Medicine, sense organs, business, Delivery of Health Care, computer, Vital sign monitoring, Environmental Monitoring, Biomedical engineering
Abstract: Reports on technological and biomedical initiatives being taken in Japan to counter bioterrorism. These include: telemedicine; noncontact vital sign monitoring using microwave radar; biomedical optical imaging of trauma diagnostics; antimicrobial photodynamic therapy; and biological weapon response.
Published: 2004

47. The Effects of Increased Enteral Feeding Immediately after the Esophageal Cancer Surgery

Author: T. Ishizuka, Yoshiaki Sugiura, Satoshi Aiko, Tadaaki Maehara, Yutaka Yoshizumi, Shinichi Tsuwano, Tomokazau Matsuyama, and Masaoki Shimanouchi
Subjects: medicine.medical_specialty, business.industry, Gastroenterology, medicine, Hemodynamics, Postoperative complication, Surgery, Esophageal cancer, business, medicine.disease, Enteral administration
Abstract: 目的: 食道癌術後の標準的管理法としている早期経腸栄養 (EN) において, 投与量増加の影響について検討した.対象と方法: 99年までの術後静脈栄養 (PN) とENのrandomized controlled trial 登録例のうち, 術前無治療の症例をおのおのPN群 (9例), EN-1群 (11例) とした.EN-1群では1POD にENを500ml/日で開始し漸増して5POD以降1,500mlとした.その後の症例 (EN-2群: 11例) では術直後より開始して3POD以降1,500mlとし, 血漿輸血を極力控えた.3 群間で水分出納, 生化学検査値, 合併症の頻度を比較した.結果: EN-2 群では投与熱量が4POD まで多く, 血糖値は4PODで有意に高かったが許容範囲内であった.水分出納は, 2PODでEN-2群のみ正の値を示し他群と有意な差があった.FFP の周術期平均投与量は, EN-2群では2Uで他群に比べ有意に少なく, 術後早期の生化学的栄養指標値はEN-2群で低値を示した.total bilirubin値は, PN群に比べ, EN-1群は5POD 以降, EN-2群は2PODより有意に低値を示した.合併症発生率に差はなかったが, 排便回数の多い症例がEN-2群にみられた.考察: 早期ENの増量は水分動態を安定化し, 血漿輸血を用いない術後管理に有用である可能性があった.高ビリルビン血症抑制効果はENの投与量増加でより強調された.早期大量EN は, 安全に施行可能だが, 厳重な観察下の投与と年齢や体表面積による補正も必要と考えた.
Published: 2004

48. [OP.6D.04] ASSOCIATION STUDY OF ANGIOTENSINASE A (ENPEP) GENOTYPE WITH DIABETIC NEPHROPATHY

Author: Yasuo Zenimaru, Jinya Suzuki, Miki Fujii, Tadashi Konoshita, M. Urabe, Michiko Imagawa, Kazuhiro Yamamoto, S. Kaeriyama, Yasukazu Makino, Takahiro Nakaya, T. Ishizuka, Satsuki Sato, Mai Ichikawa, M. Yamada, A. Sakai, and N Kato
Subjects: Diabetic nephropathy, medicine.medical_specialty, Physiology, business.industry, Internal medicine, Genotype, Internal Medicine, medicine, Cardiology and Cardiovascular Medicine, business, medicine.disease, Gastroenterology
Published: 2016

49. The non-contact monitoring of heart and respiratory rates using laser irradiation: an experimental simultaneous monitoring with and without clothes during biochemical hazards

Author: T Matsui, T Ishizuka, M Ishihara, K Matsumura, M Kikuchi, and A Kurita
Subjects: medicine.medical_specialty, business.product_category, Respiratory rate, Transducers, Biomedical Engineering, Monitoring, Ambulatory, Clothing, law.invention, Heart Rate, law, parasitic diseases, Heart rate, medicine, Animals, Irradiation, Respirator, Respiratory system, Vital sign monitoring, business.industry, Lasers, Equipment Design, General Medicine, Containment of Biohazards, Laser, Surgery, Equipment Failure Analysis, Respiratory Mechanics, Rabbits, business, Biomedical engineering
Abstract: The purpose of this study is to develop a non-contact method to evaluate the heart and respiratory rates simultaneously using a single optical sensor which can be used without the removal of clothes before a decontamination procedure in biochemical hazards. We measured the heart and respiratory rates with and without clothes to assess the vital sign monitoring before decontamination. In order to monitor the heart and respiratory rates of rabbits simultaneously, the respiratory and cardiac peaks were separated using fast Fourier transform from a 5 mW helium-neon laser (wavelength 632.8 nm) reflected off the chest walls of rabbits. A cloth (50 mm x 50 mm, 2 mm thick) was placed on the chest of the rabbits to simulate the vital sign monitoring with clothes. The heart rate measured using this method agreed with the rate derived from an electrocardiogram (r = 0.82, p0.05). The respiratory rate correlated with the manually measured respirator rate (r = 0.93, p0.05). This method appears promising as a non-contact method for monitoring the heart and respiratory rates of patients under biochemically hazardous conditions.
Published: 2003

50. Determination of solar neutrino oscillation parameters using 1496 days of Super-Kamiokande-I data

Author: Masatoshi Koshiba, Takashi Kobayashi, M. Ishitsuka, Shoichi Yamada, Takaaki Kajita, A. Kibayashi, L. R. Sulak, Shantanu Desai, Y. Ichikawa, K. Kobayashi, M. D. Messier, Y. Totsuka, T. Shibata, K. Kaneyuki, M. Takita, J. Shirai, S. Tasaka, W. E. Keig, Atsumu Suzuki, M. Earl, D. W. Liu, John G. Learned, M. Etoh, R. Nishimura, Makoto Sakuda, G. W. Sullivan, A. L. Stachyra, K. Miyano, C. W. Walter, Y. Nagashima, S. Matsuno, E. Sharkey, S. Dazeley, Hyosun Kim, D. Takemori, R. Svoboda, G. Guillian, R. W. Ellsworth, C. McGrew, A. M. Gago, K. Martens, S. Moriyama, C. Saji, J. Kameda, J. L. Stone, David William Casper, S. Nakayama, Yoshihiro Suzuki, T. Ishii, Kunio Inoue, Yoshitaka Itow, M. L. Chen, D. Turč, Y. Obayashi, J. A. Goodman, C. Mitsuda, K. S. Ganezer, T. Inagaki, Y. Kajiyama, S. Hatakeyama, R. J. Wilkes, M. Goldhaber, Y. Gando, M. Koike, Toshio Namba, Henry W. Sobel, K. Nitta, M. Ackermann, Y. Fukuda, E. Kearns, B. Viren, Koji Nakamura, S. Mine, Kyoshi Nishijima, Masayuki Nakahata, K. Nishikawa, M. Miura, Y. Takeuchi, Todd Haines, M. B. Smy, S. C. Boyd, T. Ishizuka, S. Fukuda, A. K. Ichikawa, Minoru Yoshida, C. Yanagisawa, H. Okazawa, K. Ishihara, A. Suzuki, M. Kohama, T. Iwashita, J. Hill, A. Okada, N. Sakurai, H. G. Berns, Alec Habig, Y. Watanabe, Mikio Morii, E. Blaufuss, Tsuyoshi Nakaya, C. K. Jung, C. Mauger, T. Toshito, J. Yoo, D. Kielczewska, Magdalena Malek, T. Maruyama, Masato Shiozawa, I. Kato, T. Barszczak, H. Takeuchi, Y. Hatakeyama, S. B. Kim, W. R. Kropp, Y. Oyama, Y. Hayato, Yusuke Koshio, Takehisa Hasegawa, Hirokazu Ishino, M. R. Vagins, W. Gajewski, and Kate Scholberg
Subjects: Physics, Nuclear and High Energy Physics, Particle physics, Standard solar model, Solar neutrino, High Energy Physics::Phenomenology, Solar neutrino problem, High Energy Physics - Experiment, Nuclear physics, Neutrino detector, High Energy Physics::Experiment, Neutrino, GALLEX, Super-Kamiokande, Neutrino oscillation
Abstract: A number of different fits to solar neutrino mixing and mass square difference were performed using 1496 days of Super-Kamiokande-I's solar neutrino data. These data select two allowed areas at large neutrino mixing when combined with either the solar $^8$B flux prediction of the standard solar model or the SNO interaction rate measurements. A global fit combining SK data with the solar neutrino interaction rates measured by Homestake, SNO, Gallex/GNO and SAGE prefers a single allowed area, the Large Mixing Angle solution, at the 98.9% confidence level. The mass square difference $\Delta m^2$ between the two mass eigenstates ranges from about 3 to $19\times10^{-5}$eV$^2$, while the mixing angle $\theta$ is in the range of $\tan^2\theta\approx$0.25--0.65., Comment: 10 Pages, 4 figures, submitted to Physics Letters B
Published: 2002

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