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2. Prediction of the outcome of transtrochanteric rotational osteotomy for osteonecrosis of the femoral head

Author

K. Miyanishi, Y. Noguchi, T. Yamamoto, T. Irisa, E. Suenaga, S. Jingushi, Y. Sugioka, and Y. Iwamoto

Subjects
Orthopedics and Sports Medicine, Surgery
Abstract

We have studied the correlation between the prevention of progressive collapse and the ratio of the intact articular surface of the femoral head, after transtrochanteric rotational osteotomy for osteonecrosis. We used probit analysis on 125 hips in order to assess the ratio necessary to prevent progressive radiological collapse over a ten-year period. The results show that a minimum postoperative intact ratio of 34% was required. This critical ratio may be useful for surgical planning and in assessing the natural history of the condition.

Published
2000

4. Ferromagnetic semiconductor Ge1−xCrxTe with a Curie temperature of 180K

Author

Yasuhiro Fukuma, N. Moritake, T. Irisa, Tsuyoshi Koyanagi, and Hironori Asada

Subjects
Magnetization, Magnetic anisotropy, Materials science, Physics and Astronomy (miscellaneous), Ferromagnetism, Condensed matter physics, Magnetoresistance, Hall effect, Curie temperature, Magnetic semiconductor, Spontaneous magnetization
Abstract

A IV-VI ferromagnetic semiconductor Ge1−xCrxTe (x∼0.06) with Curie temperature TC up to 180K is grown by molecular-beam epitaxy. The magnetization is well reproduced from anomalous Hall effect. As the Te∕Cr flux ratio increases during the growth of Ge1−xCrxTe, the spontaneous magnetization and the magnetic anisotropy are decreased and TC is increased. On the other hand, the Te∕Cr flux ratio over 3.6 leads to formation of Cr–Te precipitations. The magnetoresistance measurements reveal that the increase of TC is attributed to the decrease of nonstoichiometric defects.

Published
2007

5. Ferromagnetism in Ge1−xCrxTe epilayers grown by molecular beam epitaxy

Author

Tsuyoshi Koyanagi, T. Irisa, Yasuhiro Fukuma, Hironori Asada, and T. Taya

Subjects
Condensed Matter::Materials Science, Magnetization, Materials science, Physics and Astronomy (miscellaneous), Ferromagnetism, Condensed matter physics, Electrical resistivity and conductivity, Hall effect, Exchange interaction, Curie temperature, Magnetic semiconductor, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, Molecular beam epitaxy
Abstract

IV-VI ferromagnetic semiconductor Ge1−xCrxTe has been grown on BaF2 (111) by molecular beam epitaxy. The ferromagnetism was clearly established by direct magnetization and Hall measurements. The experimental correlation between the anomalous Hall resistivity ρxy and the resistivity ρxx, ρxy∝ρxx1.76, is understood from the semiclassical nature of the charge carrier dynamics, suggesting that the ferromagnetism gives rise to p-d exchange interaction. The Curie temperature increases systematically from the substrate temperature TS of 300to250to200°C and with increasing the Cr composition along with each TS.

Published
2006

6. Growth and magnetic properties of IV-VI diluted magnetic semiconductor Ge1−xCrxTe

Author

Hironori Asada, T. Irisa, Tsuyoshi Koyanagi, S. Miyawaki, T. Taya, and Y. Fukuma

Subjects
Condensed Matter::Materials Science, Magnetization, Materials science, Condensed matter physics, Ferromagnetism, Electron diffraction, Hall effect, Band gap, X-ray crystallography, General Physics and Astronomy, Magnetic semiconductor, Molecular beam epitaxy
Abstract

IV-VI diluted magnetic semiconductor Ge1−xCrxTe films were grown on BaF2 substrates by molecular-beam epitaxy. The Ge1−xCrxTe film up to x=0.103 is single phase as determined by reflection high-energy electron diffraction and x-ray diffraction measurements. The optical band gap decreases with increasing Cr composition. Ferromagnetic order of the Ge1−xCrxTe films is characterized by direct magnetization and anomalous Hall effect measurements.

Published
2006

7. CVD Growth Technologies of Layered MX2 Materials for Real LSI Applications—Position and Growth Direction Control and Gas Source Synthesis

Author

T. Irisawa, N. Okada, W. Mizubayashi, T. Mori, W.-H. Chang, K. Koga, A. Ando, K. Endo, S. Sasaki, T. Endo, and Y. Miyata

Subjects
2D layered materials, MX₂, metal dichalcogenide, TMDC, CVD, gas source, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

Position and growth direction control in chemical vapor deposition (CVD) of WS2 and SnS2 by using patterned Si/SiO2 substrates has been demonstrated. It was found that step edges effectively worked as crystal nuclei and lateral crystal growth from the edges with a certain level of growth directionality was observed. Gas source CVD using industrially friendly precursors (WF6, SnCl4, and H2S) has also been developed and WS2 and SnS2 synthesis with wafer-scale uniformity have been obtained.

Published
2018
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10. Voltage control of a magnetic switching field for magnetic tunnel junctions with low resistance and perpendicular magnetic anisotropy

Author

N. Tezuka, S. Oikawa, M. Matsuura, S. Sugimoto, K. Nishimura, T. Irisawa, Y. Nagamine, and K. Tsunekawa

Subjects
Physics, QC1-999
Abstract

The authors investigated the voltage control of a magnetic anisotropy field for perpendicular-magnetic tunnel junctions (p-MTJs) with low and high resistance-area (RA) products and for synthetic antiferromagnetic free and pinned layers. It was found that the sample with low RA products was more sensitive to the applied bias voltage than the sample with high RA products. The bias voltage effect was less pronounced for our sample with the synthetic antiferromagnetic layer for high RA products compared to the MTJs with single free and pinned layers.

Published
2018
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11. General Lectures-(II)

Author

S. Toriie, M. Nakajima, Y. Kohli, M. Takebayashi, F. Misaki, A. Kobayashi, Y. Hashimoto, Y. Mitsuyoshi, K. Ida, K. Kawai, R. Fujita, F. Kumura, M. Takahashi, H. Ohsawa, Y. Hasegawa, T. Kidokoro, Y. Jojima, H. Miyoshi, Y. Okumura, A. Yokouchi, H. Asano, A. Uehara, S. Oka, H. Saito, M. Yaginuma, T. Yamamoto, A. Asano, M. Nakamura, Y. Okada, T. Tomioka, N. Tamesue, S. Ikeda, T. Kunisaki, T. Emura, M. Yasumoto, N. Someya, A. Goto, K. Morokuma, H. Sakamoto, Y. Kasaki, K. Imamura, I. Amano, K. Iwanaga, N. Okugawa, K. Ninomiya, S. Yoshida, N. Okabe, Y. Shimogawa, Y. Akasaka, K. Shimamoto, M. Tada, K. Sugawara, I. Chikayasu, H. Takeda, T. Shibue, A. Yamaguchi, T. Osame, K. Shimada, M. Hori, T. Irisa, Y. Miura, B. Hanamure, Y. Chuman, H. Sato, M. Kizu, T. Kasugai, N. Kuno, I. Aoki, Y. Nitta, A. Machii, Y. Murakami, Y. Aiso, N. Kitahara, Y. Yoshizawa, Y. Hishinuma, Y. Nao, K. Ishiyama, M. Watanabe, T. Kimura, T. Hara, S. Sakaue, T. Shinoda, R. Ito, K. Hayashi, H. Sugie, H. Sekizawa, S. Nakamura, J. Kondo, E. Tanaka, T. Taniguchi, M. Kanayama, S. Koizumi, S. Watabiki, K. Tamura, T. Arai, T. Saito, S. Tojo, M. Furuya, H. Hanaue, K. Ogoshi, B. Murohisa, M. Uchimura, J. Ishigaki, S. Waki, H. Nakafuji, F. Iida, K. Aratake, T. Nakano, N. Ono, I. Hara, T. Sassa, T. Takahashi, J. Inoue, Y. Maruyama, Y. Mori, T. Kawamura, F. Imai, S. Yorita, M. Saegusa, F. Ishihara, I. Asukata, M. Matsuda, K. Wakabayashi, S. Mitani, K. Sugahara, K. Ishikawa, A. Nakayoshi, M. Nakamoto, A. Kono, T. Oda, Y. Sato, F. Nagao, M. Nagano, T. Furusawa, T. Nakama, H. Itoh, M. Nishimura, K. Tsutsumi, K. Yoshida, H. Ito, M. Yoshimura, K. Yoshioka, T. Shimizu, C. Kuroda, H. Uchida, O. Ishida, T. Inoue, S. Hasegawa, K. Mitsusada, Y. Kajiyama, Y. Matsuzawa, K. Yokota, Y. Hayashida, S. Ikegudhi, S. Shida, K. Tsurumi, K. Ito, K. Kamiya, H. Takada, S. Ueno, M. Onda, G. Kojima, E. Shoji, M. Miyaji, K. Goto, Y. Yazaki, M. Ito, M. Kozuka, A. Tanabe, H. Murate, T. Takeuchi, M. Koshikawa, N. Kato, K. Maeda, T. Tsuru, I. Ooyama, H. Kukimoto, Y. Nakashima, T. Katsuki, N. Ueda, T. Kanno, A. Noda, Y. Toda, T. Hayakawa, S. Nakajima, R. Morishita, K. Furukawa, F. Ikeda, M. Fujii, G. Wakisaka, Y. Matasumoto, H. Ono, S. Hirose, K. Kobayashi, N. Sawabu, J. Takeuchi, K. Kajikawa, A. Takada, Y. Hirai, I. Ohki, K. Sato, S. Tasaka, A. Sato, G. Aono, K. Takezoe, T. Ohara, S. Soma, S. Ukawa, S. Yamaguchi, T. Shirahama, K. Sugiyama, H. Koyama, M. Haga, H. Arikawa, H. Toyokawa, R. Sato, Y. Ueno, Y. Karasawa, H. Onuma, H. Suzuki, T. Murakami, A. Yasui, Y. Ichinose, Y. Hirase, T. Okazaki, T. Takai, K. Watanabe, M. Kato, M. Yamada, T. Tsuji, Y. Kunito, S. Kobayashi, K. Udo, K. Iriyama, Y. Sugiura, Y. Takahashi, O. Kawamura, S. Ando, K. Tsuji, Y. Yukawa, N. Saito, M. Miyazawa, K. Imai, T. Tabayashi, S. Umehara, Y. Watanabe, S. Murai, A. Nukaga, N. Ishimatsu, S. Sotoyama, M. Abe, K. Hirai, T. Aoki, Y. Aoki, K. Taniguchi, N. Wada, K. Tabuse, I. Yanagi, K. Tsuhada, M. Katsumi, K. Nakamura, K. Takemoto, Y. Yamaura, N. Karibe, G. Yamada, H. Ichikawa, M. Ogiwara, M. Matsushita, I. Kobayashi, M. Kusano, O. Yasuna, S. Hayashi, M. Yoshizumi, Y. Kojima, K. Matsubayashi, R. Nishimura, M. Koga, M. Tachibana, M. Kurata, H. Suto, I. Ichinose, K. Ishizuka, M. Shimoda, M. Onai, T. Akiyama, T. Sekiguchi, M. Matsuyoshi, N. Yonezawa, M. Kasamatsu, Y. Yokota, T. Toyoda, I. Uchimoto, M. Kanamoto, Y. Fukai, M. Katoh, I. Nakamura, M. Tamura, M. Nishio, Y. Mukaide, Y. Kuzumoto, K. Ota, T. Yoshida, A. Sakamoto, S. Kaneko, M. Yanagida, S. Kishimoto, K. Miyaji, Y. Shiraki, K. Inoue, T. Tamada, T. Usui, K. Ohtsuka, S. Yamada, S. Fujishima, A. Tamiya, K. Saji, A. Ueda, K. Yasutake, K. Irie, Y. Ijiri, H. Nishijima, K. Ogino, T. Okuno, H. Date, T. Yao, Y. Koga, S. Fuyuno, H. Okabe, H. Mitsui, Y. Tamechika, N. Masuda, T. Fujiwara, M. Sakimura, Y. Takamura, T. Kono, M. Kurihara, M. Sumida, T. Izumi, M. Haraikawa, H. Hayakawa, H. Shirakabe, K. Ushio, M. Okamoto, M. Noguchi, A. Kinoshita, T. Yamada, K. Shimotori, T. Kudo, I. Mukaida, H. Ishikawa, T. Shirane, A. Kano, T. Suzuki, M. Tanaka, T. Iwanaga, H. Taniguchi, M. Inawashiro, N. Endo, Sh. Suzuki, T. Maki, K. Hayakawa, H. Ikezawa, C. C. Jao, K. Yamada, M. Maruyama, K. Nagasako, I. Oi, T. Kozu, K. Yamashita, I. Yokoyama, M. Endo, T. Takemoto, K. Nakayama, R. Hayakawa, M. Ishiguro, H. Nakano, S. Nakazawa, Y. Tsuboi, H. Yamase, T. Yamashita, T. Fujita, Y. Ishikawa, N. Ito, T. Mitsuno, K. Kanazawa, M. Yamashiro, T. Kubo, H. Iizuka, T. Watanabe, M. Sanada, H. Satoh, H. Shimada, S. Kusama, K. Ikeda, J. Naramoto, Y. Okazaki, S. Kawamura, S. Fujimoto, S. Urayama, H. Matsuura, T. Sekitani, T. Sasayama, K. Nakagawa, K. Toyama, S. Nakagawa, T. Takada, K. Kusaka, S. Takaba, A. Satomura, Y. Kawakami, T. Koike, S. Joh, K. Kobayagawa, T. Hashimoto, F. Uemura, O. Fukui, Y. Takasato, K. Shirakawa, M. Hisamatsu, S. Ashizawa, Y. Sakurane, K. Miyamura, H. Sasaki, S. Ura, M. Emoto, Y. Tatsumi, Y. Totsuka, N. Chiba, M. Ozeki, M. Nakazawa, S. Takamura, Y. Sawano, T. Sugita, T. Funabiki, S. Watanabe, T. Moriya, N. Tomita, K. Nishida, A. Todo, T. Miyake, Y. Suzaki, Y. Yamamoto, J. Ariyoshi, K. Hajiro, M. Oishi, K. Yanagihara, A. Nakamura, H. Kuramata, S. Soeda, N. Kondo, M. Akashi, T. Hemmi, H. Kadono, T. Ito, R. Tsuchiya, Y. Ikeda, K. Futatsuki, S. Nomoto, I. Kino, M. Arai, H. Shimazu, O. Kobori, Y. Hiroshima, Y. Matsusaka, K. Katase, Y. Sakuma, N. Murata, K. Komura, H. Ando, K. Ohara, A. Hayashi, M. Suzuki, T. Watanuki, T. Asano, N. Koide, M. Shiobara, N. Matsuo, K. Segawa, K. Matsumoto, K. Machida, Y. Koizumi, Y. Hoshi, M. Oi, H. Seki, M. Matsumura, M. Kimura, I. Ishikawa, S. Kishi, Y. Kondo, Y. Uchida, H. Harada, M. Mandai, T. Kikuchi, K. Mishima, Y. Yamagata, T. Suyama, K. Kawagoe, T. Inagawa, T. Sugiya, T. Kai, A. Miyoshi, S. Fukumoto, H. Kojo, I. Turuhara, Y. Miyoshi, K. Okamoto, H. Inata, H. Okamoto, S. Sakurai, M. Sugiyama, K. Miura, T. Kurihara, K. Sakumoto, E. Okita, H. Tanaka, K. Ishihara, M. Okawa, N. Nishizaki, K. Saito, K. Aoyagi, E. Hamaguchi, T. Kitamura, Y. Matsuo, A. Seki, H. Mori, T. Ishikawa, T. Nakajima, T. Shimomura, K. Sengoku, Y. Uchiya, T. Yabana, M. Konta, K. Kamijo, A. Yachi, S. Okuse, H. Ohara, T. Wada, K. Furuta, M. Nishii, T. Yamawaki, K. Nishii, K. Umeda, H. Yoshida, T. Okabayashi, Y. Kato, Y. Yatsuji, Y. Suzuki, K. Nomura, K. Kamisaka, T. Motoki, K. Kamii, H. Kameda, H. Imamura, T. Uchiya, M. Ishizawa, H. Nishizaki, H. Orimo, A. Yoshida, Z. Itoh, R. Honda, S. Takeuchi, T. Fukushima, T. Suda, M. Shinonaga, N. Ishiguro, S. Fujisawa, K. Nishiyama, and T. Ohkubo

Subjects
Gastroenterology
Published
1973

12. A case of intrahepatic cholestasis due to D-penicillamine

Author

Ikuo Morotomi, T. Irisa, and Sadakichi Hirose

Subjects
medicine.medical_specialty, Hepatology, Cholestasis, business.industry, Internal medicine, Penicillamine, medicine, business, medicine.disease, Gastroenterology, medicine.drug
Published
1979

13. Clinical studies on unconjugated bilirubin metabolism in normal and pathologic states

Author

Katsuhiko Arimura, T. Irisa, Chisato Hirayama, Hiroshi Ibayashi, Hironaka Kawasaki, and Seigo Sakaguchi

Subjects
medicine.medical_specialty, Endocrinology, Hepatology, business.industry, Internal medicine, Medicine, Metabolism, business, Unconjugated bilirubin
Abstract

正常および各種疾患患者に非抱合ビリルビンを静注後,4時間までの血漿ビリルビン消失曲線をtwo compartment modelで解析して,移行率および4時間停滞率を算出した.正常対照7名の肝摂取率(a),肝より血漿への逆流率(b),肝内輸送率(m)は,それぞれ(Mean±SD) 0.0294±0.0032, 0.0139±0.0021, 0.0145±0.0041で, 4時間停滞率は9±3%であった.慢性肝炎では正常対照群に比較して, mの減少と4時間停滞率の増加に有意差を認めた.溶血性貧血では移行率, 4時間停滞率ともほぼ正常であった.またGilbert症候群では, a,mの減少,bおよび4時間停滞率の著明な増加を示した.フェノバルビタールの投与で, Gilbert症候群の血漿ビリルビンクリアランスの改善効果を認めた.一方PCB中毒症ではビリルビン代謝の亢進が示唆された.

Published
1976

14. Significance of e antigen and e antibody in liver diseases

Author

Shunichi Koga, Masanori Nakamura, Hiroshi Ibayashi, T. Irisa, and Kazuo Okochi

Subjects
Hepatology, Antigen, business.industry, Immunology, Medicine, business, Virology, E Antibody
Abstract

86名のHBs抗原陽性肝疾患患者につきe抗原,e抗体の検索を行なった.e抗原の陽性率は急性肝炎8例中2例(25%),慢性肝炎活動型26例中12例(46%),肝硬変37例中6例(16%)であり,慢性肝炎非活動型3例およびヘパトーマ12例においてはe抗原は検出できなかった.慢性肝炎患者においてe抗原陽性例はe抗原陰性例に比較してGOT,TTT,γ-グロブリンが高値を示し,肝臓の生検組織所見でもより高度の障害像が観察された.また,e抗原陽性者ではHBs抗原価が高く,RPHA法で64倍以上であり,その大部分は512倍以上の高抗原価を示していた.一方,今回検討した肝疾患患者群においてはe抗原と年齢との間には特定の関係を認めえなかった.さらに,e抗原が一過性に陽性となった急性肝炎の1症例を提示し,e抗原の出現が必ずしも肝炎の慢性化を示すものではないことを述べた.

Published
1977

15. Corticosteroid therapy in chronic active hepatitis

Author

T. Irisa, Katsuhiko Arimura, Hironaka Kawasaki, Tomofumi Ogata, and Chisato Hirayama

Subjects
Hepatitis, medicine.medical_specialty, Hepatology, Corticosteroid therapy, business.industry, Chronic Active, Internal medicine, Medicine, business, medicine.disease, Gastroenterology
Abstract

慢性肝炎活動型24例に約1年間副腎皮質ホルモン療法を行い,非投与群20例と対比検討した.副腎皮質ホルモン投与群は早期より種々の生化学検査の改善が認められ,とくにγグロブリンの改善が著明であった.副腎皮質ホルモンはガラクトースおよびビリルビン代謝能を有意に改善させたが,トルブタマイド代謝能には影響を及ぼさなかった.肝組織像は門脈域の細胞浸潤,肝細胞変性,Kupffer細胞動員に改善を認めたが,肝線維化は不変であった.副腎皮質ホルモン投与中に発症した糖尿病,消化性潰瘍は軽症であった.以上の成績は副腎皮質ホルモンによる肝間葉系反応の抑制と肝実質細胞の機能亢進にもとづくことが示唆された.

Published
1977

16. General lectures (II)

Author

K. Segawa, S. Nakazawa, N. Koide, K. Imai, N. Matsuo, Y. Yamamoto, M. Shiobara, H. Shimada, K. Kawai, K. Machida, N. Okabe, Y. Hoshi, Y. Koizumi, T. Watanuki, Y. Hiroshima, Y. Matsusaka, K. Katase, Y. Sakuma, N. Matoba, N. Murata, Y. Toyama, S. Murai, A. Nukaga, N. Ishimatsu, Y. Watanabe, M. Abe, Y. Ono, K. Hirai, S. Iwabuchi, K. Suzuki, T. Aoki, K. Masamura, K. Yoshida, J. Ikeuchi, F. Nagao, A. Kobayashi, S. Toriie, M. Nakajima, M. Kohli, K. Ida, M. Masuda, T. Hattori, S. Fujita, T. Tamada, K. Inoue, T. Usui, S. Yamaya, K. Ohtsuka, Y. Shiraki, S. Fujishima, O. Tochikubo, S. Miyamoto, A. Ueda, K. Asano, M. Kunisada, H. Miyake, Y. Fujii, S. Yoshimoto, K. Hiramatsu, S. Nakano, T. Takeda, K. Kitamura, Y. Horiguchi, K. Okada, M. Okada, T. Kuwabara, M. Tanaka, K. Konno, K. Isobe, A. Iwasaki, T. Unoura, M. Matsumoto, T. Yoshida, I. Takahashi, H. Maeda, T. Hayashi, H. Koizumi, M. Iwasaki, K. Takahashi, T. Honda, K. Ariga, S. Mohri, Y. Suga, T. Ono, K. Kobayashi, T. Mizuno, Y. Sameshima, Y. Shiozaki, M. Sasakawa, A. Hiramatsu, K. Ikehara, T. Nagata, K. Tatsumi, M. Aoki, S. Iwasaki, T. Aizawa, K. Kajiwara, K. Sata, S. Omata, K. Imamura, K. Kondo, H. Sajima, Y. Sato, H. Kiryu, S. Mimoto, T. Masuoka, K. Kira, R. Mizumoto, H. Kuratsuka, I. Honjo, Y. Hojo, H. Nakajima, T. Tosaka, O. Arai, N. Kobayashi, N. Obata, S. Ito, T. Takaoka, Y. Uragami, Y. Kitamura, S. Kishi, S. Fujii, H. Okuda, K. Hirano, H. Kano, M. Ogino, Y. Ueda, K. Nishiwaki, N. Iwamura, T. Kamada, T. Suematsu, H. Fusamoto, H. Abe, S. Katayama, K. Yamaguchi, M. Fukuda, T. Ishii, I. Kaito, S. Sato, H. Sasaki, H. Onodera, M. Yamanaka, K. Akagi, S. Miyazaki, M. Okumura, T. Omae, Y. Nakamura, M. Wada, Y. Nakai, S. Inoue, T. Arima, S. Yamasaki, T. Takano, Y. Katsuta, T. Yano, K. Isoda, T. Aramaki, N. Fukuda, T. Ichikawa, H. Okumura, Y. Adachi, R. Inoue, Y. Iwasaki, S. Tanaka, T. Yamamoto, G. Wakisaka, H. Nakaya, S. Takase, F. Ikegami, A. Takada, J. Takeuchi, Y. Kato, A. Funayama, S. Kakumu, S. Okuyama, Y. Taoka, T. Endo, R. Chizuka, T. Yanagida, S. Chizuka, H. Usui, T. Ando, T. Takai, T. Wakahara, M. Kojima, T. Fukazawa, Y. Takahashi, S. Miyamura, T. Urakawa, T. Shima, K. Miyaji, T. Okazaki, S. Kashimura, K. Koyama, H. Yamauchi, Y. Matsuo, Y. Takagi, I. Muto, Y. Owada, T. Otowa, T. Sato, C. Naito, K. Sugawara, T. Nokiba, H. Kido, M. Sasaki, Y. Sugai, G. Nishimura, H. Nanbu, Y. Kamiyama, T. Yamada, Y. Yamaoka, H. Takeda, T. Ohsawa, T. Kamano, T. Mizukami, O. Kitamura, K. Ozawa, H. Takasan, R. Miyasaki, T. Katayama, T. Amakawa, K. Hirose, Y. Furukawa, M. Noguchi, M. Okamoto, H. Maezawa, N. Tanaka, S. Yamada, T. Hisata, C. Hata, J. Sawa, Y. Mituda, S. Oohira, A. Hayasaka, T. Okuyama, S. Fukui, T. Furuichi, S. Yamamitsu, K. Yamauchi, Y. Konishi, S. Maeda, S. Setoyama, S. Otsuji, T. Ibata, H. Niu, A. Ogawa, E. Tujioka, T. Maeda, M. Takewa, T. Matumoto, K. Tamada, A. Maeda, H. Sumita, Y. Iseki, S. Yukawa, Y. Nitta, K. Isida, H. Nomoto, R. Sato, G. Sato, S. Toyokawa, G. Yamamoto, S. Ohtomi, M. Haga, Y. Ueno, R. Endo, T. Yokota, J. Ohsawa, A. Kohno, E. Ohtoshi, H. Yasugi, H. Ichikawa, K. Ando, H. Suzuki, T. Nishiwaki, T. Kishimoto, T. Miki, K. Takeshige, M. Sawada, R. Hidemura, S. Yamamoto, S. Itoh, T. Kashiwagi, M. Kishida, O. Imamura, T. Suematus, K. Sakoda, T. Kawada, Y. Arima, T. Kamimura, M. Takesue, T. Katsuki, H. Akita, Y. Yakeishi, I. Takehisa, K. Miyasato, H. Yoshida, K. Kubota, S. Aoki, S. Suzuki, T. Miyahara, K. Fujiwara, T. Sakai, T. Oda, S. Igarashi, M. Fukuhara, T. Tsujii, T. Tamura, Y. Matsuoka, H. Takahashi, T. Sakamoto, S. Fukuda, M. Oku, T. Matsui, T. Morita, Y. Oyazato, K. Kimura, W. Moriya, S. Morimoto, S. Tsuiki, K. Shoji, M. Hata, J. Kubo, K. Yoshizawa, K. Nagayama, Y. Ozawa, M. Yoshida, M. Horiguchi, A. Machii, Y. Aiso, N. Kitahara, E. Kitazawa, K. Fukuda, N. Saiti, Y. Murakami, Y. Nao, I. Okazaki, K. Funatsu, K. Maruyama, B. Takagi, S. Yasuraoka, K. Ishii, S. Matsuzaki, H. Ishii, K. Kamegaya, K. Sambe, H. Ishikawa, Y. Tajima, A. Kuroda, Y. Ishihara, N. Sato, I. Ishikawa, T. Noro, Y. Kakumoto, H. S. Mekjian, N. R. Thomford, T. Yokomura, S. Adachi, A. Yamamoto, I. Saito, A. Kawamura, M. Miyata, S. Kasai, N. Kawanishi, A. Tamaki, M. Mito, Y. Kasai, A. Hasumi, T. Uchiyama, Y. Tachikawa, T. Takanashi, T. Kanke, K. Matsuda, G. Hamana, M. Sakuma, T. Sugita, K. Tomita, T. Tsuzuki, M. Uekusa, M. Matsuzaki, M. Tsuchiya, M. Uchimura, T. Murohisa, Y. Muto, J. Ishigaki, S. Waki, R. Tsuchiya, M. Sho, M. Furukawa, N. Suzuki, H. Nagashima, T. Matsushiro, T. Saitoh, N. Nakamura, T. Hatanaka, K. Tooi, Y. Tanaka, N. Kadokura, Y. Okada, I. Yanakgi, V. M. Sekiya, K. Adachi, M. Miyashita, Y. Moriyama, M. Onda, M. Yoshioka, T. Teraoka, Y. Shimizu, G. Fujishima, K. Ookawa, M. Miki, A. Shirota, K. Aihara, T. Shiga, H. Sano, S. Hayashi, M. Hori, H. Sato, Y. Chuman, S. Tsukase, N. Nakahara, S. Ehira, H. Nishimata, T. Irisa, K. Tokutome, Y. Nakashima, H. Koga, H. Yokoyama, T. Otsuji, Y. Chujo, S. Gotoda, S. Uchiyama, G. Kosaki, H. Ohkura, T. Mukojima, N. Hattori, O. Sasaki, K. Soejima, K. Inokuchi, J. Utsunomiya, T. Maki, T. Iwama, Y. Matsunaga, T. Shimomura, T. Nakajima, S. Ichikawa, T. Miyanaga, K. Sengoku, E. Hamaguchi, N. Aoki, T. Nomura, A. Matsuoka, A. Nagahama, T. Kazumi, H. Miyawaki, K. Miyasaki, K. Kato, Y. Miyazaki, N. Harada, K. Yamada, S. Tashiro, K. Sakai, N. Ho, H. Murayama, M. Yada, T. Sakabe, H. Shimizu, M. Kuroki, S. Nishida, S. Ishiyama, K. Yukawa, M. Hayashi, K. Soh, K. Doi, A. Nakagawa, E. Yukawa, Y. Uematsu, K. Nara, H. Hattori, M. Watanabe, K. Sato, S. Okuse, T. Murotani, S. Takasu, M. Konta, T. Uchiya, N. Fujimaki, K. Yoshikawa, M. Uchida, S. Kawana, K. Tamura, T. Hashimoto, T. Hara, J. Nosaka, O. Fukui, E. Inaba, S. Otsukasa, K. Sanada, H. Hiraide, G. Senyo, A. Ootani, T. Nakayama, S. Takei, H. Miki, S. Minota, K. Nakayama, K. Nakagawa, T. Shiraishi, H. Kawauchi, H. Nagaya, K. Mizushima, Y. Tachimi, M. Namiki, K. Masuda, N. Mitsutani, T. Mukuta, T. Koizumi, T. Takeuchi, T. Nemoto, H. Takabayashi, M. Takagi, Y. Hongo, H. Kojima, M. Nishimura, S. Hino, J. Hirayama, M. Nakamura, S. Koga, C. Hirayama, S. Kikuch, M. Ito, S. Hidano, T. Ooya, H. Banno, A. Tomura, T. Koyama, T. Takei, T. Tomimura, M. Yamauchi, Y. Nakaya, Y. Matsuda, K. Udo, N. Hukuda, M. Kametani, T. Miyagawa, T. Imaeda, K. Senda, H. Okubo, K. Kanoda, B. Miyashita, H. Ishizuka, T. Goto, K. Oto, H. Kaneda, M. Hase, J. Matsuda, T. Kawai, H. Ikehara, S. Baba, M. Ishii, T. Tozawa, E. Inoue, N. Mizuno, S. Saeki, T. Nakaji, T. Narabayashi, T. Okuno, H. Yamada, M. Tanno, K. Chiba, M. Iio, K. Shibata, F. Furuhashi, K. Mizuochi, S. Ohashi, M. Nakano, S. Otsuka, M. Irie, M. Akima, Y. Maruyama, F. Oyamada, E. Nagata, Y. Kubo, T. Arishima, Y. Otsuyama, A. Kaneto, Y. Shimogawa, K. Tanigawa, K. Nakajima, S. Onishi, A. Kasahara, T. Shimizu, Y. Ikehara, H. Tajima, A. Okamoto, T. Komibuchi, T. Negoro, A. Nihonsugi, Y. Ogawa, H. Otani, M. Ishida, H. Yashima, M. Ryo, T. Tanaka, K. Taketa, A. Watanabe, Y. Yumoto, A. Tanaka, A. Takesue, H. Aoe, M. Ueda, J. Shimamura, K. Kosaka, E. Kashiwara, K. Orita, E. Konaga, S. Kaneda, K. Ogawa, H. Tamura, S. Okanishi, T. Ueda, H. Horie, M. Kamachi, T. Asihara, R. Daido, T. Izumi, M. Kurihara, M. Sumida, M. Haraikawa, H. Hayakawa, H. Shirakabe, and A. Yasui

Subjects
medicine.medical_specialty, Common bile duct, business.industry, Digitoxin, General surgery, Gastroenterology, Hepatology, Colorectal surgery, Duodenal ulcer, medicine.anatomical_structure, Surgical oncology, Internal medicine, medicine, Obstructive jaundice, business, Abdominal surgery, medicine.drug
Published
1974

17. Fasting serum bile acid level in chronic liver disease

Author

Masanori Nakamura, Seigo Sakaguchi, Chisato Hirayama, T. Irisa, Hironaka Kawasaki, Katsuhiko Arimura, and Shunichi Koga

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, medicine, Serum bile acid level, Chronic liver disease, medicine.disease, business, Gastroenterology
Abstract

正常ならびに各種肝疾患患者血清について胆汁酸をAmberlite XAD-2で分離後非アルコール性溶媒にとかし,酵素法による蛍光度測定によって定量した.正常健康人の空腹時血清胆汁酸は,3±2nmole/mlであり,急性肝炎で著明に増加,慢性肝疾患では,その重症度に比例して増加した.血清胆汁酸は,慢性肝疾患において,血清ビリルビンのほか,アルブミン,γグロブリン,BSP試験などと有意の相関関係がみとめられた.

Published
1975

18. [Untitled]

Author

H. Kitagawa, R. Kato, Y. Yamaoka, H. Takeda, H. Nanbu, Y. Kamiyama, N. Yamada, T. Ohsawa, T. Kamano, T. Mizukami, O. Kitamura, K. Ozawa, H. Takasan, I. Honjo, A. Takada, Y. Matsuda, F. Ikegami, A. Tanaka, T. Kobayashi, H. Kono, T. Yamamoto, S. Tanaka, Y. Adachi, S. Nomoto, K. Arimura, T. Irisa, H. Kawasaki, and C. Hirayama

Subjects
Hepatology
Published
1973

19. General lectures (II)

Author

Y. Karasawa, H. Ōnuma, H. Suzuki, T. Okazaki, A. Yasui, T. Murakami, K. Furuya, M. Ohtsuki, H. Sata, T. Kondo, H. Takada, K. Kawaguchi, S. Sai, S. Takeda, M. Kitagawa, T. Morooka, T. Shiraishi, M. Namiki, H. Kawauchi, K. Nakagawa, H. Kuramata, Y. Yamaguchi, T. Kabakino, T. Inokuchi, J. Wakisaka, Y. Yamauchi, T. Debuchi, W. Ogo, C. Yamasaki, M. Sigemori, K. Hashimoto, T. Shirozu, N. Kaibara, K. Inokuchi, K. Soejima, T. Hiyama, M. Wakita, T. Ikemoto, H. Hayasaka, S. Fukui, T. Takeda, N. Aoyama, Y. Takada, Y. Saheki, Y. Yoshida, K. Minagawa, T. Okuyama, S. Yamamitsu, Y. Konishi, N. Ishimatsu, S. Murai, A. Nukaga, S. Toyama, Y. Watanabe, N. Mizushima, M. Abe, K. Maruyama, K. Yoshino, T. Suzuki, K. Akisato, M. Kitajima, T. Tabata, M. Hashimoto, T. Tanaka, Y. Nakagawa, Y. Ishii, M. Inoue, S. Katayama, Y. Nakano, M. Fukuda, M. Takaki, H. Hyodo, J. Kobayashi, H. Nishikawa, K. Morimoto, T. Takagi, S. Sako, H. Tomoda, M. Furusawa, R. Sassa, T. Unuma, T. Iwase, T. Yoshioka, M. Kusakabe, M. Iio, S. Kobayashi, M. Kizu, T. Kasugai, K. Yoshida, T. Kembo, T. Yoshida, Y. Suga, T. Suguro, Y. Kono, S. Mitsui, Y. Nagamachi, T. Nakamura, H. Suto, T. Higuchi, M. Onai, K. Isizuka, A. Takei, M. Simoda, T. Sekiguchi, K. Shichijo, Y. Akashi, K. Mori, K. Ogasawara, R. Tanaka, K. Yoshikawa, T. Takahashi, T. Ogata, S. Tanaka, T. Seito, H. Matsuda, T. Imajo, K. Moriyasu, Y. Takata, H. Kamei, H. Murai, T. Takemitsu, T. Kanemitsu, M. Ishii, M. Imaizumi, M. Inada, G. B. J. Glass, K. Ebata, N. Yamanaka, S. Watanabe, H. Mori, S. Tsukasa, H. Sato, Y. Chuman, N. Nakahara, H. Taniguchi, S. Ehira, M. Hori, T. Irisa, H. Yokoyama, T. Kunieda, Y. Ogushi, K. Kawakami, M. Kuroda, D. Sasaki, S. SŌma, S. Yanagiya, A. Munakata, F. Matsunaga, M. Abiko, H. Ohuchi, C. Tai, T. Kawashima, W. Oosawa, H. Asakura, H. Senba, T. Hatayama, K. Yukawa, T. Konishi, M. Miyata, H. Shimazu, T. Kinoshita, K. Nukada, T. Yamagishi, K. Harada, S. Nakano, T. Sakai, K. Shindo, K. Fukushima, S. Odagiri, K. Tarao, Y. Saito, K. Ohara, S. Sasaki, T. Tomoda, N. Kaneda, H. Yamaguchi, T. Hayashi, J. Suzuki, Y. Kofune, A. Urase, A. Yamagata, N. Sugino, M. Hatano, K. Oshima, T. Tanabe, M. Ohto, K. Okuda, E. Mitani, S. Yamamoto, K. Kobayashi, T. Ono, T. Kamata, S. Mohri, H. Makiishi, A. Kitano, S. Tatumi, S. Mizuno, K. Tsumori, T. Shimizu, K. Nomatsu, H. Hiratsuka, M. Ichinose, T. Morishita, A. Morita, S. Matsuzaki, M. Oda, K. Kamegaya, M. Tuchiya, K. Sambe, Y. Murakami, A. Machii, Y. Nitta, Y. Aiso, N. Kitahara, M. Sato, Y. Yoshizawa, Y. Hishinuma, H. Nagasako, Y. Nao, H. Harada, K. Mishima, Y. Yamagata, M. Mandai, Y. Kondo, Y. Uchida, S. Takizawa, S. Kinoshita, T. Kurihara, K. Sakumoto, H. Okamoto, S. Sakurai, S. Ishitobi, H. Tanaka, K. Ishihara, N. Kuno, I. Aoki, Y. Horiguchi, K. Kitamura, M. Miwa, K. Okada, Y. Endo, M. Tatsuta, T. Morii, S. Okuda, H. Tamura, K. Fukuda, K. Sato, K. Koizumi, T. Takebe, S. Yamagata, S. Noda, Y. Toda, T. Hayakawa, S. Nakajima, S. Hitokawa, N. Sawabu, S. Hirose, A. Takada, J. Takeuchi, Y. Kuniyasu, H. Kakehi, G. Uchiyama, N. Arimizu, T. Kuroda, H. Saishyo, T. Takashima, M. Shin, M. Akashi, T. Moriyama, M. Uchimura, R. Tsuchiya, G. Kakizaki, N. Noto, T. Oizumi, T. Soeno, T. Maeta, T. Saito, S. Naito, K. Shimizu, T. Nakajima, M. Tanaka, T. Kin, S. Sugiyama, H. Takayama, T. Tomono, N. Kamijo, Y. Kimura, T. Matsuo, M. Shimada, B. Terashima, S. Furuta, K. Kashiwabara, S. Oka, M. Sugiura, M. Karasawa, K. Ito, K. Takei, Y. Ishihara, A. Kuroda, N. Sato, T. Noro, H. Ishikawa, Y. Tajima, S. Hashihira, T. Nishii, R. Mori, Y. Takeda, T. Yamadori, A. Wakabayashi, S. Iwata, M. Shiraso, K. Tokutake, S. Matsuno, N. Haga, Y. Suda, T. Sato, T. Tsunoda, H. Kanno, Y. Aneha, K. Kikuchi, K. Imamura, O. Kondo, Y. Yuki, S. Omata, S. Okamoto, H. Nagahara, H. Motoyama, H. Watanabe, T. Maekawa, T. Miyakawa, Y. Anazawa, T. Motoyama, T. Kawamura, Y. Kusaka, F. Shima, S. Abe, S. Ichihara, M. Nomura, T. Ushiyama, S. Futagawa, M. Ishida, G. Obata, Y. Sugiyama, K. Suzuki, M. Abo, M. Takeuchi, E. Tann, K. Kimura, A. Iwaya, H. Takahashi, K. Ono, J. Inoue, S. Miyaishi, T. Sasaki, Y. Kuroyanagi, H. Kato, C. Kido, K. Hibino, M. Kishikawa, T. Takeuchi, H. Murate, A. Tanabe, M. Kozuka, M. Ito, N. Kato, Y. Yazaki, K. Goto, M. Miyaji, J. Yokoi, I. Endo, S. Kato, M. Miyazaki, N. Murayama, A. Kawamura, B. Murohisa, S. Hirai, M. Furukawa, G. Nakashima, H. Furuse, T. Fukuda, F. Hanyu, N. Sakakibara, H. Ide, K. Momma, H. Nagashima, T. Matsushiro, N. Suzuki, T. Saitoh, N. Nakamura, W. Takahashi, T. Hatanaka, N. Kobayashi, M. Hagano, T. Furusawa, T. Osuga, O. W. Portman, K. Takahashi, H. Kibayashi, H. Yamazaki, K. Komaki, H. Tanimura, Y. Hikasa, R. Ogawa, H. Nakagawa, M. Osada, H. Koizumi, M. Katayama, H. Sakamoto, T. Manome, M. Sesoko, M. Kobayashi, Y. Komine, N. Watanabe, Y. Okabe, M. Ogino, T. Naruke, T. Hoshika, T. Miyano, K. Tsuneoka, S. Kitajima, I. Nakada, Y. Sasamori, H. Munakata, K. Tanaka, H. Oguro, T. Numata, K. Oh-Uti, S. Goto, K. Takashina, G. Sasaki, A. Kimura, T. Sasagawa, G. Takahashi, H. Sugiyama, K. Iwaki, S. Okada, M. Iwasaki, Y. Kawashima, H. Kaneda, T. Honda, K. Ariga, Woo pak Sa, H. Hozawa, T. Susuki, Y. Kato, T. Mizuno, H. Oya, S. Yoshino, and T. Hattori

Subjects
Gastroenterology
Published
1973

20. Contents, Vol. 7, 1972

Author

A. Ribet, M. Nakamura, H. Khazrai, R. Debeus, J.S. Davison, D. Dhumeaux, M. Gaetani, L. Simon, R. Lambert, T. Irisa, J.L. Balmes, J.-M. Metreau, P. Berthelot, F. Descos, J. Frexinos, C. Hirayama, K. Tominaga, A.I. Figus, Claude André, J. Fournajoux, B. Cayrol, and J.P. Bali

Subjects
Gastroenterology
Published
1972

21. First International Gstaad Symposium: The Liver Quantitative Aspects of Structure and Function

Author

P. Berthelot, C. Hirayama, J. Frexinos, F. Descos, Claude André, A. Ribet, H. Khazrai, K. Tominaga, T. Irisa, J. Fournajoux, R. Lambert, J.S. Davison, R. Debeus, J.L. Balmes, A.I. Figus, D. Dhumeaux, M. Gaetani, M. Nakamura, J.-M. Metreau, B. Cayrol, J.P. Bali, and L. Simon

Subjects
Gastroenterology, Biophysics, Biology, Neuroscience, Structure and function
Published
1972

22. Subject Index, Vol. 7, 1972

Author

J.S. Davison, C. Hirayama, B. Cayrol, L. Simon, A. Ribet, A.I. Figus, P. Berthelot, R. Debeus, R. Lambert, M. Gaetani, F. Descos, J.L. Balmes, T. Irisa, H. Khazrai, J.-M. Metreau, J. Frexinos, J. Fournajoux, J.P. Bali, Claude André, D. Dhumeaux, M. Nakamura, and K. Tominaga

Subjects
Index (economics), Statistics, Gastroenterology, Subject (documents), Mathematics
Published
1972

23. DC magnetic field type eddy current speed sensor detecting cross magnetization field with amorphous core

Author

T. Irisa, Ryuzo Ueda, T. Sonoda, K. Fujitani, and S. Tatata

Subjects
Materials science, Demagnetizing field, Magnetic particle inspection, Inductor, Magnetostatics, Magnetic flux, Electronic, Optical and Magnetic Materials, Computational physics, law.invention, Nuclear magnetic resonance, Magnetic core, law, Eddy current, Amorphous metal transformer, Electrical and Electronic Engineering
Abstract

A new dc magnetic field type eddy current speed sensor is presented using an amorphous core of zero-magnetostriction and sharp rectangular B-H loop. In the proposed sensor, a constant dc magnetic flux passes through the surface of a moving conductor of which speed should be detected. So induced eddy currents become a pure function of the speed. The magnetized field produced with the currents, which is called "cross magnetization field" in this paper, is detected with high sensitivity by using such an amorphous core. A "zero flux method" is applied to the detection and it achieves a stable and driftless sensing almost without delay. By making a slight modification, the speed is detectable even if the gap-length between the conductor and the sensor changes. Experimental results are shown.

Published
1985

24. Authors’ Index, Vol. 7, 1972

Author

J. Frexinos, L. Simon, C. Hirayama, H. Khazrai, F. Descos, K. Tominaga, Claude André, P. Berthelot, D. Dhumeaux, R. Lambert, M. Nakamura, B. Cayrol, J.P. Bali, J.S. Davison, J. Fournajoux, A. Ribet, R. Debeus, M. Gaetani, J.-M. Metreau, A.I. Figus, J.L. Balmes, and T. Irisa

Subjects
Index (economics), Statistics, Gastroenterology, Mathematics
Published
1972

25. Studies on the relationship of hepatic anion-binding proteins and sulfobromophthalein-glutathione conjugation in normal and phenobarbital-treated rats

Author

Seigo Sakaguchi, K. Tominaga, Hiroshi Ibayashi, C. Hirayama, Katsuhiko Arimura, Kawasaki H, and T. Irisa

Subjects
Male, Size-exclusion chromatography, Biophysics, Biochemistry, Sulfobromophthalein, chemistry.chemical_compound, medicine, Animals, Anion binding, Molecular Biology, Chromatography, biology, Chemistry, Glutathione, In vitro, Enzyme assay, Enzymes, Rats, Liver, Sephadex, Phenobarbital, biology.protein, Chromatography, Gel, medicine.drug, Protein Binding
Abstract

The enzyme activity which conjugates sulfobromophthalein with glutathione was separated from rat liver supernate by Sephadex G-75 gel filtration, and assayed by two different methods; paper electrophoresis and spectrophotometry. The enzyme activity was found mainly in the second protein fraction, and less than 5% of the activity in the first or third protein fractions. In vitro mixtures of sulfobromophthalein, [ 3 H]glutathione and rat liver supernate showed that the major part of [ 3 H]glutathione was detected in the first and second protein fractions, and the remainder in the third protein fraction. Phenobarbital treatment caused an increase of the enzyme activity, sulfobromophthalein and [ 3 H]glutathione, in the second protein fraction.

Published
1975

26. Value of B-scan ultrasonography in the diagnosis of liver cancer. Accuracy compared to scintigraphy and angiography

Author

H, Kawasaki, S, Sakaguchi, T, Irisa, and C, Hirayama

Subjects
Adult, Male, Liver Neoplasms, Angiography, Humans, Female, alpha-Fetoproteins, Diagnostic Errors, Middle Aged, Neoplasm Metastasis, Radionuclide Imaging, Aged, Ultrasonography
Abstract

Seventy-one patients with liver cancer were examined by B-scan ultrasonography. The presence of liver cancer was assumed through the irregularity and increased intensity of echos. The accuracy of ultrasonography in the diagnosis of liver cancer was 72%, while the diagnostic accuracy of scintigraphy was 85% and angiography 93%. No obvious correlation could be demonstrated between the ultrasonographic patterns and serum alpha-fetoprotein (AFP) levels. Ultrasonography is a useful method of detecting liver cancer.

Published
1978

27. Diagnostic significance of fasting serum bile acid in liver disease

Author

C, Hirayama, T, Irisa, K, Arimura, and M, Nakamura

Subjects
Bile Acids and Salts, Fatty Liver, Liver Cirrhosis, Carcinoma, Hepatocellular, Liver Function Tests, Acute Disease, Chronic Disease, Liver Neoplasms, Humans, Hepatitis
Abstract

Serum bile acid was extracted with Amberlite XAD-2 followed by determination with an enzymatic and fluorimetric technique. Normal value for fasting serum bile acid was found to be 3 +/- 2 muM. Serum bile acid level was raised markedly early in the course of acute viral hepatitis, subsequently fell rapidly before resolution of biochemical tests, and was elevated again in relapse. In chronic liver disease serum bile acid was elevated moderately and correlated roughly with disease severity. In comparison with routine biochemical tests, serum bile acid correlated significantly with serum bilirubin, BSP retention and other hepatic tests, except serum cholesterol. Thus fasting serum bile acid level is a reliable screening test for a variety of liver disease to assess functional and morphological impairment of the liver.

Published
1976

28. A NOVEL APPROACH ON PARAMETER SELF-TUNING METHOD IN AC SERVO SYSTEM

Author

T. Irisa, S. Takata, R. Ueda, T. Sonoda, and T. Mochizuki

Subjects
Inductance, Computer science, law, Control theory, Stator, Rotor (electric), Time constant, Transient (oscillation), Servomechanism, Pulse-width modulation, Voltage, law.invention
Abstract

This paper describes a newly developed parameter identification method of induction machine. Identification procedure consists of two steps: one is at initial state of standstill and the other is at operating state. In each step, on-line identification of parameters indispensable to description of machine dynamics can be realized by observing behaviors of stator current and voltage. They are stator winding self-inductance, transient inductance, rotor circuit time constant and stator winding resistance. At standstill state, they are identified from stator voltage wave to ramp current. At operating state these parameters are also identified by solving a set of equations obtained from vectorial relation between stator current and voltage. This identification technique is applied to PWM drive system and can lead to parameter self-tuning in ac servo control system.

Published
1984

29. Effect of corticosteroid treatment on bilirubin metabolism in chronic aggressive hepatitis

Author

H, Kawasaki, T, Ogata, T, Irisa, and C, Hirayama

Subjects
Adult, Male, Glucaric Acid, Prednisolone, Chronic Disease, Humans, Bilirubin, Female, Middle Aged, Hepatitis
Abstract

The metabolism of unconjugated bilirubin from the plasma was studied in 17 patients with chronic hepatitis and 7 normal subjects following a single injection of bilirubin of 2 mg per kg body weight. From the plasma disappearance curves of unconjugated bilirubin, hepatic uptake, reflux from the liver to the plasma and hepatic conjugation were calculated by 2 compartmental analysis. The clearance remained within normal range in 5 patients with chronic persistent hepatitis but was significantly impaired in 12 patients with chronic aggressive hepatitis, in which corticosteroid treatment improved the clearance significantly (p less than 0.01). Since urinary excretion of d-glucaric acid remained unchanged by corticosteroid treatment, the improved clearance may be attributable to increased hepatic parenchymal function.

Published
1977

33. [Congenital non-hemolytic and non-conjugating-type hyperbilirubinemia]

Author

H, Kawasaki, K, Sakai, T, Irisa, H, Amagase, and C, Hirayama

Subjects
Indocyanine Green, Adolescent, Tolbutamide, Bilirubin, Sulfobromophthalein, Menthol, Microscopy, Electron, Liver, Hyperbilirubinemia, Hereditary, Iodine Isotopes, Phenobarbital, Humans, Female, Radionuclide Imaging
Published
1971

34. Serum gamma-globulins and hepatitis-associated antigen in blood donors, chronic liver disease and primary hepatoma

Author

M. Nakamura, C. Hirayama, T. Irisa, and K. Tominaga

Subjects
Immunoglobulin A, Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Immunodiffusion, Cirrhosis, Carcinoma, Hepatocellular, Adolescent, Blood Donors, Chronic liver disease, Gastroenterology, Immunoglobulin G, Hepatitis, Hepatitis B Antigens, Antigen, Internal medicine, Medicine, Humans, Child, Immunoelectrophoresis, Aged, biology, business.industry, Liver Diseases, Liver Neoplasms, Gamma globulin, Middle Aged, medicine.disease, Immunoglobulin M, Child, Preschool, Chronic Disease, biology.protein, Female, gamma-Globulins, business
Abstract

Serum level of γ-globulins was studied on 100 blood donors, 30 patients with chronic hepatitis, 51 patients with liver cirrhosis and 43 patients with primary hepatoma in regard to hepatitis-associated antigen (HAA). Blood donors with HAA had an increased level of γA as compared with subjects lacking HAA. In chronic hepatitis, no difference was recorded between the positive and the negative group. Liver cirrhosis patients with HAA had a raised level of γM and hepatoma patients with HAA seemed to have a raised level of γ-globulins, as compared with patients lacking HAA.

Published
1972

36. Ultrasono-tomographic diagnosis of liver diseases (I) diagnosis of liver cancer

Author

S. Sakaguchi, Kawasaki H, T. Irisa, C. Hirayama, and T. Hlrata

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, Cancer, Alcoholic hepatitis, Hepatology, medicine.disease, Colorectal surgery, Surgical oncology, Internal medicine, medicine, Liver cancer, Primary liver cancer, business, Abdominal surgery
Published
1972

39. Genetic characteristics in liver cirrhosis

Author

K. Tominaga, M. Nakamura, C. Hirayama, T. Irisa, Shunichi Koga, and Kawasaki H

Subjects
medicine.medical_specialty, Cirrhosis, Surgical oncology, business.industry, Internal medicine, General surgery, Gastroenterology, medicine, Hepatology, medicine.disease, business, Colorectal surgery, Abdominal surgery
Published
1973

40. Hepatic collagenolytic activity under chronic carbon tetrachloride intoxication

Author

Kaichiro Hiroshige, C. Hirayama, T. Masuya, H. Toda, I. Morotomi, N. Kimura, and T. Irisa

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, Hepatology, Colorectal surgery, chemistry.chemical_compound, Hydroxyproline, chemistry, Surgical oncology, Internal medicine, Carbon tetrachloride, Medicine, Cysteamine, business, Hepatic fibrosis, Abdominal surgery
Published
1969

41. [Utility of the Filter Extraction Method for Detecting Anticancer Drug Contamination in Air].

Author

Irisa T, Hata K, Nakashima K, Nakayama Y, Hashimoto K, Ishida S, Watanabe H, Tsuji T, and Egashira N

Subjects
Cyclophosphamide, Drug Contamination, Humans, Air Pollutants, Occupational analysis, Antineoplastic Agents analysis, Occupational Exposure
Abstract

The filter extraction method is a new, simple method for evaluating anticancer drug contamination in air. The method involves installing a filter in the exhaust port of an exhaust duct on a facility's air conditioner, then collecting and measuring fine particles of the antineoplastic agents adsorbed onto the filter. In this study, we analyzed the utility of maintaining continuous filter extraction for measuring cyclophosphamide and 5-fluorouracil contamination. The filters were installed in 3 areas of an outpatient chemotherapy room and then left in place for approximately 5 months. Results revealed the presence of cyclophosphamide and 5-fluorouracil in all 3 areas. However, the amounts and ratios of detected drugs differed among survey sites; this may have been caused by factors such as drug preparation, administration, and excretion. We conclude that the filter extraction method can be used continuously for monitoring anticancer drug contamination in air; thus, it can be utilized to monitor healthcare workers' occupational exposure to inhaled anticancer drugs. Indeed, the filter extraction method may be useful as a novel environmental monitoring technique.

Published
2020

42. Control of seed dormancy and germination by DOG1-AHG1 PP2C phosphatase complex via binding to heme.

Author

Nishimura N, Tsuchiya W, Moresco JJ, Hayashi Y, Satoh K, Kaiwa N, Irisa T, Kinoshita T, Schroeder JI, Yates JR 3rd, Hirayama T, and Yamazaki T

Subjects
Arabidopsis genetics, Arabidopsis metabolism, Arabidopsis Proteins metabolism, Gene Expression Regulation, Developmental, Gene Expression Regulation, Plant, Heme metabolism, Mutation, Phosphoprotein Phosphatases metabolism, Plants, Genetically Modified, Protein Binding, Seeds growth & development, Seeds metabolism, Arabidopsis Proteins genetics, Germination genetics, Phosphoprotein Phosphatases genetics, Plant Dormancy genetics, Seeds genetics
Abstract

Abscisic acid (ABA) regulates abiotic stress and developmental responses including regulation of seed dormancy to prevent seeds from germinating under unfavorable environmental conditions. ABA HYPERSENSITIVE GERMINATION1 (AHG1) encoding a type 2C protein phosphatase (PP2C) is a central negative regulator of ABA response in germination; however, the molecular function and regulation of AHG1 remain elusive. Here we report that AHG1 interacts with DELAY OF GERMINATION1 (DOG1), which is a pivotal positive regulator in seed dormancy. DOG1 acts upstream of AHG1 and impairs the PP2C activity of AHG1 in vitro. Furthermore, DOG1 has the ability to bind heme. Binding of DOG1 to AHG1 and heme are independent processes, but both are essential for DOG1 function in vivo. Our study demonstrates that AHG1 and DOG1 constitute an important regulatory system for seed dormancy and germination by integrating multiple environmental signals, in parallel with the PYL/RCAR ABA receptor-mediated regulatory system.

Published
2018
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43. The Relationship between Occurrence Timing of Dispensing Errors and Subsequent Danger to Patients under the Situation According to the Classification of Drugs by Efficacy.

Author

Tsuji T, Nagata K, Kawashiri T, Yamada T, Irisa T, Murakami Y, Kanaya A, Egashira N, and Masuda S

Subjects
Health Knowledge, Attitudes, Practice, Humans, Incidence, Medication Errors prevention & control, Medication Errors statistics & numerical data, Pharmaceutical Preparations classification, Pharmacists, Risk Adjustment, Risk Assessment
Abstract

There are many reports regarding various medical institutions' attempts at the prevention of dispensing errors. However, the relationship between occurrence timing of dispensing errors and subsequent danger to patients has not been studied under the situation according to the classification of drugs by efficacy. Therefore, we analyzed the relationship between position and time regarding the occurrence of dispensing errors. Furthermore, we investigated the relationship between occurrence timing of them and danger to patients. In this study, dispensing errors and incidents in three categories (drug name errors, drug strength errors, drug count errors) were classified into two groups in terms of its drug efficacy (efficacy similarity (-) group, efficacy similarity (+) group), into three classes in terms of the occurrence timing of dispensing errors (initial phase errors, middle phase errors, final phase errors). Then, the rates of damage shifting from "dispensing errors" to "damage to patients" were compared as an index of danger between two groups and among three classes. Consequently, the rate of damage in "efficacy similarity (-) group" was significantly higher than that in "efficacy similarity (+) group". Furthermore, the rate of damage is the highest in "initial phase errors", the lowest in "final phase errors" among three classes. From the results of this study, it became clear that the earlier the timing of dispensing errors occurs, the more severe the damage to patients becomes.

Published
2016
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44. Differences in recognition of similar medication names between pharmacists and nurses: a retrospective study.

Author

Tsuji T, Irisa T, Tagawa S, Kawashiri T, Ikesue H, Kokubu C, Kanaya A, Egashira N, and Masuda S

Abstract

Background: Differences in error rates between pharmacists and nurses in terms of drug confirmation have not been studied. The purpose of this study was to analyze differences in error rates between pharmacists and nurses from the viewpoint of error categories, and to clarify differences in recognition regarding drug name similarity., Methods: In this study, preparation errors and incidents were classified into three categories (drug strength errors, drug name errors, and drug count errors) to investigate the influence of error categories on pharmacists and nurses. In addition, errors in two categories (drug strength errors and drug name errors) were reclassified into another two error groups, to investigate the influence of drug name similarity on pharmacists and nurses: a "drug name similarity (-) group" and a "drug name similarity (+) group". Then, differences in error rates of pharmacists and those of nurses were analyzed respectively within three categories and two groups. Furthermore, differences in error rates between pharmacists and nurses were analyzed in each of the three categories and two groups., Results: Error rates of pharmacists for both drug strength errors and drug name errors were significantly higher than that for drug count errors, and similar results were obtained for nurses (P < 0.05). However, there were no significant differences in error rates between pharmacists and nurses in each of the three categories. Furthermore, error rate of nurses was significantly higher than that of pharmacists in the drug name similarity (+) group (P < 0.05), while there was no significant difference in error rates between pharmacists and nurses in the drug name similarity (-) group., Conclusions: These results suggest that in contrast to pharmacists, nurses are easily affected by similarities in drug names. Therefore, pharmacists should offer information on medications having plural strengths or similar names to nurses, in order to minimize damage to patients resulting from errors.

Published
2015
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45. Relationship between incident types and impact on patients in drug name errors: a correlational study.

Author

Tsuji T, Irisa T, Ohata S, Kokubu C, Kanaya A, Sueyasu M, Egashira N, and Masuda S

Abstract

Background: There are many reports regarding various medical institutions' attempts at incident prevention, but the relationship between incident types and impact on patients in drug name errors has not been studied. Therefore, we analyzed the relationship between them, while also assessing the relationship between preparation and inspection errors. Furthermore, the present study aimed to clarify the incident types that lead to severe patient damage., Methods: The investigation object in this study was restricted to "drug name errors", preparation and inspection errors in them were classified into three categories (similarity of drug efficacy, similarity of drug name, similarity of drug appearance) or two groups (drug efficacy similarity (+) group, drug efficacy similarity (-) group). Then, the relationship between preparation and inspection errors was investigated in three categories, the relationship between incident types and impact on patients was examined in two groups., Results: The frequency of preparation errors was liable to be caused by the following order: similarity of drug efficacy > similarity of drug name > similarity of drug appearance. In contrast, the rate of inspection errors was liable to be caused by the following order: similarity of drug efficacy < similarity of drug name < similarity of drug appearance. In addition, the number of preparation errors in the drug efficacy similarity (-) group was fewer than that in the drug efficacy similarity (+) group. However, the rate of inspection errors in the drug efficacy similarity (-) group was significantly higher than that in the drug efficacy similarity (+) group. Furthermore, the occupancy rate of preparation errors, incidents more than Level 0, 1, and 2 in the drug efficacy similarity (-) group increased gradually according to the rise of patient damage., Conclusions: Our results suggest that preparation errors caused by the similarity of drug appearance and/or drug name are likely to lead to the incidents (inspection errors), and these incidents are likely to cause severe damage to patients subsequently.

Published
2015
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46. Reduction of nitric oxide catalyzed by hydroxylamine oxidoreductase from an anammox bacterium.

Author

Irisa T, Hira D, Furukawa K, and Fujii T

Subjects
Bacteria metabolism, Benzyl Viologen metabolism, Electron Transport, Hydrazines metabolism, Hydrazines pharmacology, Hydroxylamine metabolism, Kinetics, Nitrosomonas enzymology, Nitrosomonas metabolism, Oxidation-Reduction, Bacteria enzymology, Biocatalysis, Nitric Oxide metabolism, Oxidoreductases metabolism
Abstract

The hydroxylamine oxidoreductase (HAO) from the anammox bacterium, Candidatus Kuenenia stuttgartiensis has been reported to catalyze the oxidation of hydroxylamine (NH2OH) to nitric oxide (NO) by using bovine cytochrome c as an oxidant. In contrast, we investigated whether the HAO from anammox bacterium strain KSU-1 could catalyze the reduction of NO with reduced benzyl viologen (BVred) and the NO-releasing reagent, NOC 7. The reduction proceeded, resulting in the formation of NH2OH as a product. The oxidation rate of BVred was proportional to the concentration of BVred itself for a short period in each experiment, a situation that was termed quasi-steady state. The analyses of the states at various concentrations of HAO allowed us to determine the rate constant for the catalytic reaction, (2.85 ± 0.19) × 10(5) M(-1) s(-1), governing NO reduction by BVred and HAO, which was comparable to that reported for the HAO from the ammonium oxidizer, Nitrosomonas with reduced methyl viologen. These results suggest that the anammox HAO functions to adjust anammox by inter-conversion of NO and NH2OH depending on the redox potential of the physiological electron transfer protein in anammox bacteria., (Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.)

Published
2014
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47. Dose effects of corticosteroids on the development of osteonecrosis in rabbits.

Author

Motomura G, Yamamoto T, Irisa T, Miyanishi K, Nishida K, and Iwamoto Y

Subjects
Animals, Disease Models, Animal, Dose-Response Relationship, Drug, Male, Rabbits, Adrenal Cortex Hormones adverse effects, Methylprednisolone adverse effects, Osteonecrosis chemically induced
Abstract

Objective: The relationship between dose of corticosteroids and the prevalence of osteonecrosis (ON) has not been established. We examined the dose effects of corticosteroids on the development of ON in a rabbit model., Methods: Rabbits were injected once intramuscularly with 1 (12 rabbits), 5 (12 rabbits), 20 (20 rabbits), and 40 (25 rabbits) mg/kg of methylprednisolone acetate (MPSL) into the right gluteus medius muscle. Four weeks after the MPSL injection, the proximal and distal parts of both the femora and humeri were histopathologically examined for the presence of ON. Hematological examinations were performed before and after the corticosteroid injection., Results: In rabbits with 1, 5, 20, and 40 mg/kg MPSL, the incidence of ON was 0, 42%, 70%, and 96%, respectively. The dose of MPSL showed a significant association with the incidence of ON. Histologically, reparative tissues around the ON sites were observed in the rabbits with 5 mg/kg MPSL, but not observed in rabbits with 20 and 40 mg/kg MPSL. On hematological examination, hyperlipidemia and thrombocytopenia were most apparent in the rabbits receiving 40 mg/kg MPSL., Conclusion: The study suggested that the dose of corticosteroids plays an important role in the development of ON in rabbits. The repair process was also found to be influenced by the dose of corticosteroids. Corticosteroid-induced hyperlipidemia and thrombocytopenia seemed to be associated with the incidence of ON.

Published
2008
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48. Effects of tacrolimus (FK506) on the development of osteonecrosis in a rabbit model.

Author

Miyanishi K, Yamamoto T, Irisa T, Yamashita A, Motomura G, Jingushi S, and Iwamoto Y

Subjects
Animals, Disease Models, Animal, Immunosuppressive Agents antagonists & inhibitors, Lipoproteins, LDL blood, Lipoproteins, VLDL blood, Male, Osteonecrosis pathology, Osteonecrosis prevention & control, Rabbits, Steroids administration & dosage, Tacrolimus antagonists & inhibitors, Immunosuppressive Agents toxicity, Osteonecrosis chemically induced, Tacrolimus toxicity
Abstract

The present study examined the effects of tacrolimus (FK506) on the development of osteonecrosis in rabbits. In Experiment A, rabbits were given FK506, and also given a single dose of steroid. Control rabbits were given the same dose of steroid only. In Experiment B, rabbits were given FK506 and a reduced dose of steroid. The results showed that addition of FK506 did not change the number of rabbits with osteonecrosis when an identical steroid dose was given. When the steroid dose was reduced, the osteonecrosis incidence significantly decreased (p < 0.01). These results suggest that the clinically reported decrease in the osteonecrosis incidence following the introduction of FK506 is most likely attributable to the lower doses of steroids.

Published
2008
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49. Effects of cyclosporin A on the development of osteonecrosis in rabbits.

Author

Miyanishi K, Yamamoto T, Irisa T, Yamashita A, Motomura G, Jingushi S, and Iwamoto Y

Subjects
Animals, Dose-Response Relationship, Drug, Femur Head Necrosis chemically induced, Femur Head Necrosis prevention & control, Glucocorticoids administration & dosage, Methylprednisolone administration & dosage, Rabbits, Cyclosporine administration & dosage, Femur Head Necrosis etiology, Immunosuppressive Agents administration & dosage, Organ Transplantation adverse effects
Abstract

Background: Osteonecrosis (ON) of the femoral head is a serious complication in patients who have undergone organ transplantation. Introduction of cyclosporin A has resulted in lower-dosage steroid treatment and a decrease in the occurrence of ON. We examined the effect of cyclosporin A on the development of ON in rabbits., Methods: In experiment A, rabbits were given cyclosporin A and 20 mg/kg methylprednisolone acetate. The control group was given 20 mg/kg methylprednisolone acetate only. Experiment B was then performed to mimic the clinical situation in which the use of cyclosporin A and lower steroid doses resulted in a decrease in occurrence of ON. In Experiment C, the effects of treatment with cyclosporin A only on development of ON were examined. 4 weeks after injection, bilateral femora and humeri were examined histopathologically for ON., Results: Cyclosporin A increased the incidence of ON in rabbits when given in combination with steroid (p = 0.04). No ON lesions were observed in rabbits treated with cyclosporin A alone., Interpretation: Our findings suggest that the clinically reported reduction in occurrence of ON following the use of cyclosporin A is probably attributable to the lower steroid doses used.

Published
2006
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50. Control of self-aggregation of fullerenes by connection with calix[4]arene: solvent- and guest-effects to particle size.

Author

Ikeda A, Irisa T, Hamano T, Kitahashi T, Sasaki Y, Hashizume M, Kikuchi J, Konishi T, and Shinkai S

Abstract

A new molecular design of fullerene derivatives exhibiting trigger-responsive self-aggregation in organic solvents has been established. Calix[4]arene was covalently connected with fullerene in order to apply host-guest interaction to the aggregation control. The self-assembly behaviour was studied in organic solvents by UV-vis absorption spectroscopy, dynamic light scattering and transmission electron microscopy. Results show that the bisfullerene formed self-aggregations with a low polydispersity index due to the fullerenes' tendency to aggregate in polar organic solvents. Furthermore, the aggregate sizes can be changed readily by solvent composition and the addition of guest cations. Especially, disaggregation of the bisfullerene was induced by addition of LiClO4 or NaClO4.

Published
2006
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