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1. Case Report: Esophageal squamous cell carcinoma in a 13-year-old boy with a history of esophageal atresia with tracheoesophageal fistula

Author

B. Bernar, C. Mayerhofer, T. Fuchs, G. Schweigmann, E. Gassner, R. Crazzolara, B. Hetzer, U. Klingkowski, A. Zschocke, and G. Cortina

Subjects
esophageal atresia, ESCC (esophageal squamous cell carcinoma), child—age, esophageal repair, cancer, Pediatrics, RJ1-570
Abstract

In adults, esophageal cancers are a global health concern. Esophageal squamous cell carcinoma (ESCC) accounts for approximately 90% of esophageal carcinomas. The prognosis of esophageal cancers remains dismal, with a five-year survival rate below 20%. It typically affects older patients, and for now, ESCC after esophageal atresia has not been reported in patients younger than 18 years. We present an exceptional case of an ESCC in a 13-year-old boy with a history of esophageal atresia and corrective surgery in infancy. After the surgery the patient was lost to surgical follow up for over ten years and then presented to our emergency department with respiratory distress requiring antibiotic therapy and supplemental oxygen. Radiologic imaging revealed a volume reduction of the right lung with bronchiectasis, as well as esophageal stenosis at the level of the previous anastomosis, with an adjacent abscess in the right lung. These changes may have arisen due to a chronic fistula from the esophagus to the right lung. Initial interventional therapy with a stent implantation had no lasting success and, in an effort to prevent further aspiration into the right lung, a cervical esophagus stoma was established, and the patient received prolonged antibiotic treatment. However, a thoracic CT scan performed 4 months later revealed a large, retrospectively progressive prevertebral mass originating from the distal portion of the esophagus below the stenosis, compressing the trachea and the right main bronchus. The patient's condition rapidly worsened and he developed respiratory failure, requiring veno-venous extracorporeal membrane oxygenation. Unfortunately, an endoscopic biopsy revealed an advanced ESCC. With no rational treatment options available, we changed the goals of care to a palliative setting. The key message of this case is that in adolescents with chronic infections, an abscess can potentially mask a malignant transformation. Therefore, in adolescents, with an history of corrective surgery for esophageal atresia and chronic complications, consideration should also be given to the possibility of squamous cell carcinoma of the esophagus.

Published
2024
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2. Establishment of a reliable in-vivo model of implant-associated infection to investigate innovative treatment options

Author

C. Kreis, F. K. Aschenbrenner, D. Günther, N. Tholema-Hans, J. Koeppe, S. B. Rosslenbroich, M. J. Raschke, and T. Fuchs

Subjects
Medicine, Science
Abstract

Abstract The increasing number of implant-associated infections and of multiresistant pathogens is a major problem in the daily routine. In the field of osteomyelitis, it is difficult to manage a valid clinical study because of multiple influencing factors. Therefore, models of osteomyelitis with a simulation of the pathophysiology to evaluate treatment options for implant-associated infections are necessary. The aim of this study is to develop a standardized and reproducible osteomyelitis model in-vivo to improve treatment options. This study analyses the influence of a post-infectious implant exchange one week after infection and the infection progress afterward in combination with a systemic versus a local antibiotic treatment in-vivo. Therefore, the implant exchange, the exchange to a local drug-delivery system with gentamicin, and the implant removal are examined. Furthermore, the influence of an additional systemic antibiotic therapy is evaluated. An in-vivo model concerning the implant exchange is established that analyzes clinic, radiologic, microbiologic, histologic, and immunohistochemical diagnostics to obtain detailed evaluation and clinical reproducibility. Our study shows a clear advantage of the combined local and systemic antibiotic treatment in contrast to the implant removal and to a non-combined antibiotic therapy. Group genta/syst. showed the lowest infection rate with a percentage of 62.5% concerning microbiologic analysis, which is in accordance with the immunohistochemical, cytochemical, histologic, and radiologic analysis. Our in-vivo rat model has shown valid and reproducible results, which will lead to further investigations regarding treatment options and influencing factors concerning the therapy of osteomyelitis and implant-associated infections.

Published
2022
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3. Erratum to: Search for annihilating dark matter in the Sun with 3 years of IceCube data

Author

M. G. Aartsen, M. Ackermann, J. Adams, J. A. Aguilar, M. Ahlers, M. Ahrens, D. Altmann, K. Andeen, T. Anderson, I. Ansseau, G. Anton, M. Archinger, C. Argüelles, J. Auffenberg, S. Axani, X. Bai, S. W. Barwick, V. Baum, R. Bay, J. J. Beatty, J. Becker Tjus, K.-H. Becker, S. BenZvi, D. Berley, E. Bernardini, A. Bernhard, D. Z. Besson, G. Binder, D. Bindig, M. Bissok, E. Blaufuss, S. Blot, C. Bohm, M. Börner, F. Bos, D. Bose, S. Böser, O. Botner, J. Braun, L. Brayeur, H.-P. Bretz, S. Bron, A. Burgman, T. Carver, M. Casier, E. Cheung, D. Chirkin, A. Christov, K. Clark, L. Classen, S. Coenders, G. H. Collin, J. M. Conrad, D. F. Cowen, R. Cross, M. Day, J. P. A. M. de André, C. De Clercq, E. del Pino Rosendo, H. Dembinski, S. De Ridder, P. Desiati, K. D. de Vries, G. de Wasseige, M. de With, T. DeYoung, J. C. Díaz-Vélez, V. di Lorenzo, H. Dujmovic, J. P. Dumm, M. Dunkman, B. Eberhardt, T. Ehrhardt, B. Eichmann, P. Eller, S. Euler, P. A. Evenson, S. Fahey, A. R. Fazely, J. Feintzeig, J. Felde, K. Filimonov, C. Finley, S. Flis, C.-C. Fösig, A. Franckowiak, E. Friedman, T. Fuchs, T. K. Gaisser, J. Gallagher, L. Gerhardt, K. Ghorbani, W. Giang, L. Gladstone, T. Glauch, T. Glüsenkamp, A. Goldschmidt, J. G. Gonzalez, D. Grant, Z. Griffith, C. Haack, A. Hallgren, F. Halzen, E. Hansen, T. Hansmann, K. Hanson, D. Hebecker, D. Heereman, K. Helbing, R. Hellauer, S. Hickford, J. Hignight, G. C. Hill, K. D. Hoffman, R. Hoffmann, K. Hoshina, F. Huang, M. Huber, K. Hultqvist, S. In, A. Ishihara, E. Jacobi, G. S. Japaridze, M. Jeong, K. Jero, B. J. P. Jones, W. Kang, A. Kappes, T. Karg, A. Karle, U. Katz, M. Kauer, A. Keivani, J. L. Kelley, A. Kheirandish, J. Kim, M. Kim, T. Kintscher, J. Kiryluk, T. Kittler, S. R. Klein, G. Kohnen, R. Koirala, H. Kolanoski, R. Konietz, L. Köpke, C. Kopper, S. Kopper, D. J. Koskinen, M. Kowalski, K. Krings, M. Kroll, G. Krückl, C. Krüger, J. Kunnen, S. Kunwar, N. Kurahashi, T. Kuwabara, M. Labare, J. L. Lanfranchi, M. J. Larson, F. Lauber, D. Lennarz, M. Lesiak-Bzdak, M. Leuermann, L. Lu, J. Lünemann, J. Madsen, G. Maggi, K. B. M. Mahn, S. Mancina, M. Mandelartz, R. Maruyama, K. Mase, R. Maunu, F. McNally, K. Meagher, M. Medici, M. Meier, A. Meli, T. Menne, G. Merino, T. Meures, S. Miarecki, T. Montaruli, M. Moulai, R. Nahnhauer, U. Naumann, G. Neer, H. Niederhausen, S. C. Nowicki, D. R. Nygren, A. Obertacke Pollmann, A. Olivas, A. O’Murchadha, T. Palczewski, H. Pandya, D. V. Pankova, P. Peiffer, Ö. Penek, J. A. Pepper, C. Pérez de los Heros, D. Pieloth, E. Pinat, P. B. Price, G. T. Przybylski, M. Quinnan, C. Raab, L. Rädel, M. Rameez, K. Rawlins, R. Reimann, B. Relethford, M. Relich, E. Resconi, W. Rhode, M. Richman, B. Riedel, S. Robertson, M. Rongen, C. Rott, T. Ruhe, D. Ryckbosch, D. Rysewyk, L. Sabbatini, S. E. Sanchez Herrera, A. Sandrock, J. Sandroos, S. Sarkar, K. Satalecka, P. Schlunder, T. Schmidt, S. Schoenen, S. Schöneberg, L. Schumacher, D. Seckel, S. Seunarine, D. Soldin, M. Song, G. M. Spiczak, C. Spiering, T. Stanev, A. Stasik, J. Stettner, A. Steuer, T. Stezelberger, R. G. Stokstad, A. Stößl, R. Ström, N. L. Strotjohann, G. W. Sullivan, M. Sutherland, H. Taavola, I. Taboada, J. Tatar, F. Tenholt, S. Ter-Antonyan, A. Terliuk, G. Tešić, S. Tilav, P. A. Toale, M. N. Tobin, S. Toscano, D. Tosi, M. Tselengidou, A. Turcati, E. Unger, M. Usner, J. Vandenbroucke, N. van Eijndhoven, S. Vanheule, M. van Rossem, J. van Santen, M. Vehring, M. Voge, E. Vogel, M. Vraeghe, C. Walck, A. Wallace, M. Wallraff, N. Wandkowsky, Ch. Weaver, M. J. Weiss, C. Wendt, S. Westerhoff, B. J. Whelan, S. Wickmann, K. Wiebe, C. H. Wiebusch, L. Wille, D. R. Williams, L. Wills, M. Wolf, T. R. Wood, E. Woolsey, K. Woschnagg, D. L. Xu, X. W. Xu, Y. Xu, J. P. Yanez, G. Yodh, S. Yoshida, and M. Zoll

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

In the analysis published in 1, constraints on the number of signal events can be interpreted as constraints on the volumetric neutrino to muon conversion rate.

Published
2019
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4. Erratum to: Search for non-relativistic magnetic monopoles with IceCube

Author

M. G. Aartsen, R. Abbasi, M. Ackermann, J. Adams, J. A. Aguilar, M. Ahlers, D. Altmann, C. Arguelles, T. C. Arlen, J. Auffenberg, X. Bai, M. Baker, S. W. Barwick, V. Baum, R. Bay, J. J. Beatty, J. Becker Tjus, K. -H. Becker, M. L. Benabderrahmane, S. BenZvi, P. Berghaus, D. Berley, E. Bernardini, A. Bernhard, D. Z. Besson, G. Binder, D. Bindig, M. Bissok, E. Blaufuss, J. Blumenthal, D. J. Boersma, C. Bohm, D. Bose, S. Böser, O. Botner, L. Brayeur, H. -P. Bretz, A. M. Brown, R. Bruijn, J. Casey, M. Casier, D. Chirkin, A. Christov, B. Christy, K. Clark, L. Classen, F. Clevermann, S. Coenders, S. Cohen, D. F. Cowen, A. H. Cruz Silva, M. Danninger, J. Daughhetee, J. C. Davis, M. Day, J. P. A. M. de André, C. De Clercq, S. De Ridder, P. Desiati, K. D. de Vries, M. de With, T. DeYoung, J. C. Díaz-Vélez, M. Dunkman, R. Eagan, B. Eberhardt, B. Eichmann, J. Eisch, S. Euler, P. A. Evenson, O. Fadiran, A. R. Fazely, A. Fedynitch, J. Feintzeig, T. Feusels, K. Filimonov, C. Finley, T. Fischer-Wasels, S. Flis, A. Franckowiak, K. Frantzen, T. Fuchs, T. K. Gaisser, J. Gallagher, L. Gerhardt, L. Gladstone, T. Glüsenkamp, A. Goldschmidt, G. Golup, J. G. Gonzalez, J. A. Goodman, D. Góra, D. T. Grandmont, D. Grant, P. Gretskov, J. C. Groh, A. Groß, C. Ha, C. Haack, A. Haj Ismail, P. Hallen, A. Hallgren, F. Halzen, K. Hanson, D. Hebecker, D. Heereman, D. Heinen, K. Helbing, R. Hellauer, S. Hickford, G. C. Hill, K. D. Hoffman, R. Hoffmann, A. Homeier, K. Hoshina, F. Huang, W. Huelsnitz, P. O. Hulth, K. Hultqvist, S. Hussain, A. Ishihara, E. Jacobi, J. Jacobsen, K. Jagielski, G. S. Japaridze, K. Jero, O. Jlelati, B. Kaminsky, A. Kappes, T. Karg, A. Karle, M. Kauer, J. L. Kelley, J. Kiryluk, J. Kläs, S. R. Klein, J. -H. Köhne, G. Kohnen, H. Kolanoski, L. Köpke, C. Kopper, S. Kopper, D. J. Koskinen, M. Kowalski, M. Krasberg, A. Kriesten, K. Krings, G. Kroll, J. Kunnen, N. Kurahashi, T. Kuwabara, M. Labare, H. Landsman, M. J. Larson, M. Lesiak-Bzdak, M. Leuermann, J. Leute, J. Lünemann, O. Macías, J. Madsen, G. Maggi, R. Maruyama, K. Mase, H. S. Matis, F. McNally, K. Meagher, A. Meli, M. Merck, T. Meures, S. Miarecki, E. Middell, N. Milke, J. Miller, L. Mohrmann, T. Montaruli, R. Morse, R. Nahnhauer, U. Naumann, H. Niederhausen, S. C. Nowicki, D. R. Nygren, A. Obertacke, S. Odrowski, A. Olivas, A. Omairat, A. O’Murchadha, T. Palczewski, L. Paul, J. A. Pepper, C. Pérez de los Heros, C. Pfendner, D. Pieloth, E. Pinat, J. Posselt, P. B. Price, G. T. Przybylski, M. Quinnan, L. Rädel, M. Rameez, K. Rawlins, P. Redl, R. Reimann, E. Resconi, W. Rhode, M. Ribordy, M. Richman, B. Riedel, S. Robertson, J. P. Rodrigues, C. Rott, T. Ruhe, B. Ruzybayev, D. Ryckbosch, S. M. Saba, H. -G. Sander, M. Santander, S. Sarkar, K. Schatto, F. Scheriau, T. Schmidt, M. Schmitz, S. Schoenen, S. Schöneberg, A. Schönwald, A. Schukraft, L. Schulte, O. Schulz, D. Seckel, Y. Sestayo, S. Seunarine, R. Shanidze, C. Sheremata, M. W. E. Smith, D. Soldin, G. M. Spiczak, C. Spiering, M. Stamatikos, T. Stanev, N. A. Stanisha, A. Stasik, T. Stezelberger, R. G. Stokstad, A. Stößl, E. A. Strahler, R. Ström, N. L. Strotjohann, G. W. Sullivan, H. Taavola, I. Taboada, A. Tamburro, A. Tepe, S. Ter-Antonyan, G. Tešić, S. Tilav, P. A. Toale, M. N. Tobin, S. Toscano, M. Tselengidou, E. Unger, M. Usner, S. Vallecorsa, N. van Eijndhoven, J. van Santen, M. Vehring, M. Voge, M. Vraeghe, C. Walck, M. Wallraff, Ch. Weaver, M. Wellons, C. Wendt, S. Westerhoff, B. J. Whelan, N. Whitehorn, K. Wiebe, C. H. Wiebusch, D. R. Williams, H. Wissing, M. Wolf, T. R. Wood, K. Woschnagg, D. L. Xu, X. W. Xu, J. P. Yanez, G. Yodh, S. Yoshida, P. Zarzhitsky, J. Ziemann, S. Zierke, and M. Zoll

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

In the analyses, published in Ref. [1], the exclusion limits are calculated in dependence of the mean free path of the magnetic monopole - nucleon catalysis interaction.

Published
2019
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5. Measurement of the $$\nu _{\mu }$$ νμ energy spectrum with IceCube-79

Author

M. G. Aartsen, M. Ackermann, J. Adams, J. A. Aguilar, M. Ahlers, M. Ahrens, I. Al Samarai, D. Altmann, K. Andeen, T. Anderson, I. Ansseau, G. Anton, M. Archinger, C. Argüelles, J. Auffenberg, S. Axani, H. Bagherpour, X. Bai, S. W. Barwick, V. Baum, R. Bay, J. J. Beatty, J. Becker Tjus, K.-H. Becker, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, C. Bohm, M. Börner, F. Bos, D. Bose, S. Böser, O. Botner, F. Bradascio, J. Braun, L. Brayeur, H.-P. Bretz, S. Bron, A. Burgman, T. Carver, M. Casier, E. Cheung, D. Chirkin, A. Christov, K. Clark, L. Classen, S. Coenders, G. H. Collin, J. M. Conrad, D. F. Cowen, R. Cross, M. Day, J. P. A. M. de André, C. De Clercq, E. del Pino Rosendo, H. Dembinski, S. De Ridder, P. Desiati, K. D. de Vries, G. de Wasseige, M. de With, T. DeYoung, J. C. Díaz-Vélez, V. di Lorenzo, H. Dujmovic, J. P. Dumm, M. Dunkman, B. Eberhardt, T. Ehrhardt, B. Eichmann, P. Eller, S. Euler, P. A. Evenson, S. Fahey, A. R. Fazely, J. Feintzeig, J. Felde, K. Filimonov, C. Finley, S. Flis, C.-C. Fösig, A. Franckowiak, E. Friedman, T. Fuchs, T. K. Gaisser, J. Gallagher, L. Gerhardt, K. Ghorbani, W. Giang, L. Gladstone, T. Glauch, T. Glüsenkamp, A. Goldschmidt, J. G. Gonzalez, D. Grant, Z. Griffith, C. Haack, A. Hallgren, F. Halzen, E. Hansen, T. Hansmann, K. Hanson, D. Hebecker, D. Heereman, K. Helbing, R. Hellauer, S. Hickford, J. Hignight, G. C. Hill, K. D. Hoffman, R. Hoffmann, K. Hoshina, F. Huang, M. Huber, K. Hultqvist, S. In, A. Ishihara, E. Jacobi, G. S. Japaridze, M. Jeong, K. Jero, B. J. P. Jones, W. Kang, A. Kappes, T. Karg, A. Karle, U. Katz, M. Kauer, A. Keivani, J. L. Kelley, A. Kheirandish, J. Kim, M. Kim, T. Kintscher, J. Kiryluk, T. Kittler, S. R. Klein, G. Kohnen, R. Koirala, H. Kolanoski, R. Konietz, L. Köpke, C. Kopper, S. Kopper, D. J. Koskinen, M. Kowalski, K. Krings, M. Kroll, G. Krückl, C. Krüger, J. Kunnen, S. Kunwar, N. Kurahashi, T. Kuwabara, A. Kyriacou, M. Labare, J. L. Lanfranchi, M. J. Larson, F. Lauber, D. Lennarz, M. Lesiak-Bzdak, M. Leuermann, L. Lu, J. Lünemann, J. Madsen, G. Maggi, K. B. M. Mahn, S. Mancina, R. Maruyama, K. Mase, R. Maunu, F. McNally, K. Meagher, M. Medici, M. Meier, T. Menne, G. Merino, T. Meures, S. Miarecki, J. Micallef, G. Momenté, T. Montaruli, M. Moulai, R. Nahnhauer, U. Naumann, G. Neer, H. Niederhausen, S. C. Nowicki, D. R. Nygren, A. Obertacke Pollmann, A. Olivas, A. O’Murchadha, T. Palczewski, H. Pandya, D. V. Pankova, P. Peiffer, Ö. Penek, J. A. Pepper, C. Pérez de los Heros, D. Pieloth, E. Pinat, P. B. Price, G. T. Przybylski, M. Quinnan, C. Raab, L. Rädel, M. Rameez, K. Rawlins, R. Reimann, B. Relethford, M. Relich, E. Resconi, W. Rhode, M. Richman, B. Riedel, S. Robertson, M. Rongen, C. Rott, T. Ruhe, D. Ryckbosch, D. Rysewyk, L. Sabbatini, S. E. Sanchez Herrera, A. Sandrock, J. Sandroos, S. Sarkar, K. Satalecka, P. Schlunder, T. Schmidt, S. Schoenen, S. Schöneberg, L. Schumacher, D. Seckel, S. Seunarine, D. Soldin, M. Song, G. M. Spiczak, C. Spiering, J. Stachurska, T. Stanev, A. Stasik, J. Stettner, A. Steuer, T. Stezelberger, R. G. Stokstad, A. Stößl, R. Ström, N. L. Strotjohann, G. W. Sullivan, M. Sutherland, H. Taavola, I. Taboada, J. Tatar, F. Tenholt, S. Ter-Antonyan, A. Terliuk, G. Tešić, S. Tilav, P. A. Toale, M. N. Tobin, S. Toscano, D. Tosi, M. Tselengidou, C. F. Tung, A. Turcati, E. Unger, M. Usner, J. Vandenbroucke, N. van Eijndhoven, S. Vanheule, M. van Rossem, J. van Santen, M. Vehring, M. Voge, E. Vogel, M. Vraeghe, C. Walck, A. Wallace, M. Wallraff, N. Wandkowsky, A. Waza, Ch. Weaver, M. J. Weiss, C. Wendt, S. Westerhoff, B. J. Whelan, S. Wickmann, K. Wiebe, C. H. Wiebusch, L. Wille, D. R. Williams, L. Wills, M. Wolf, T. R. Wood, E. Woolsey, K. Woschnagg, D. L. Xu, X. W. Xu, Y. Xu, J. P. Yanez, G. Yodh, S. Yoshida, and M. Zoll

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract IceCube is a neutrino observatory deployed in the glacial ice at the geographic South Pole. The $$\nu _\mu $$ νμ energy unfolding described in this paper is based on data taken with IceCube in its 79-string configuration. A sample of muon neutrino charged-current interactions with a purity of 99.5% was selected by means of a multivariate classification process based on machine learning. The subsequent unfolding was performed using the software Truee. The resulting spectrum covers an E$$_\nu $$ ν -range of more than four orders of magnitude from 125 GeV to 3.2 PeV. Compared to the Honda atmospheric neutrino flux model, the energy spectrum shows an excess of more than $$1.9\,\sigma $$ 1.9σ in four adjacent bins for neutrino energies $$E_\nu \ge 177.8\,\text {TeV}$$ Eν≥177.8TeV . The obtained spectrum is fully compatible with previous measurements of the atmospheric neutrino flux and recent IceCube measurements of a flux of high-energy astrophysical neutrinos.

Published
2017
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6. Search for neutrinos from dark matter self-annihilations in the center of the Milky Way with 3 years of IceCube/DeepCore

Author

M. G. Aartsen, M. Ackermann, J. Adams, J. A. Aguilar, M. Ahlers, M. Ahrens, I. Al Samarai, D. Altmann, K. Andeen, T. Anderson, I. Ansseau, G. Anton, C. Argüelles, J. Auffenberg, S. Axani, H. Bagherpour, X. Bai, J. P. Barron, S. W. Barwick, V. Baum, R. Bay, J. J. Beatty, J. Becker Tjus, K. -H. Becker, S. BenZvi, D. Berley, E. Bernardini, D. Z. Besson, G. Binder, D. Bindig, E. Blaufuss, S. Blot, C. Bohm, M. Börner, F. Bos, D. Bose, S. Böser, O. Botner, J. Bourbeau, F. Bradascio, J. Braun, L. Brayeur, M. Brenzke, H. -P. Bretz, S. Bron, A. Burgman, T. Carver, J. Casey, M. Casier, E. Cheung, D. Chirkin, A. Christov, K. Clark, L. Classen, S. Coenders, G. H. Collin, J. M. Conrad, D. F. Cowen, R. Cross, M. Day, J. P. A. M. de André, C. De Clercq, J. J. DeLaunay, H. Dembinski, S. De Ridder, P. Desiati, K. D. de Vries, G. de Wasseige, M. de With, T. DeYoung, J. C. Díaz-Vélez, V. di Lorenzo, H. Dujmovic, J. P. Dumm, M. Dunkman, B. Eberhardt, T. Ehrhardt, B. Eichmann, P. Eller, P. A. Evenson, S. Fahey, A. R. Fazely, J. Felde, K. Filimonov, C. Finley, S. Flis, A. Franckowiak, E. Friedman, T. Fuchs, T. K. Gaisser, J. Gallagher, L. Gerhardt, K. Ghorbani, W. Giang, T. Glauch, T. Glüsenkamp, A. Goldschmidt, J. G. Gonzalez, D. Grant, Z. Griffith, C. Haack, A. Hallgren, F. Halzen, K. Hanson, D. Hebecker, D. Heereman, K. Helbing, R. Hellauer, S. Hickford, J. Hignight, G. C. Hill, K. D. Hoffman, R. Hoffmann, B. Hokanson-Fasig, K. Hoshina, F. Huang, M. Huber, K. Hultqvist, S. In, A. Ishihara, E. Jacobi, G. S. Japaridze, M. Jeong, K. Jero, B. J. P. Jones, P. Kalacynski, W. Kang, A. Kappes, T. Karg, A. Karle, U. Katz, M. Kauer, A. Keivani, J. L. Kelley, A. Kheirandish, J. Kim, M. Kim, T. Kintscher, J. Kiryluk, T. Kittler, S. R. Klein, G. Kohnen, R. Koirala, H. Kolanoski, L. Köpke, C. Kopper, S. Kopper, J. P. Koschinsky, D. J. Koskinen, M. Kowalski, K. Krings, M. Kroll, G. Krückl, J. Kunnen, S. Kunwar, N. Kurahashi, T. Kuwabara, A. Kyriacou, M. Labare, J. L. Lanfranchi, M. J. Larson, F. Lauber, D. Lennarz, M. Lesiak-Bzdak, M. Leuermann, Q. R. Liu, L. Lu, J. Lünemann, W. Luszczak, J. Madsen, G. Maggi, K. B. M. Mahn, S. Mancina, R. Maruyama, K. Mase, R. Maunu, F. McNally, K. Meagher, M. Medici, M. Meier, T. Menne, G. Merino, T. Meures, S. Miarecki, J. Micallef, G. Momenté, T. Montaruli, R. W. Moore, M. Moulai, R. Nahnhauer, P. Nakarmi, U. Naumann, G. Neer, H. Niederhausen, S. C. Nowicki, D. R. Nygren, A. Obertacke Pollmann, A. Olivas, A. O’Murchadha, T. Palczewski, H. Pandya, D. V. Pankova, P. Peiffer, J. A. Pepper, C. Pérez de los Heros, D. Pieloth, E. Pinat, M. Plum, P. B. Price, G. T. Przybylski, C. Raab, L. Rädel, M. Rameez, K. Rawlins, R. Reimann, B. Relethford, M. Relich, E. Resconi, W. Rhode, M. Richman, B. Riedel, S. Robertson, M. Rongen, C. Rott, T. Ruhe, D. Ryckbosch, D. Rysewyk, T. Sälzer, S. E. Sanchez Herrera, A. Sandrock, J. Sandroos, S. Sarkar, K. Satalecka, P. Schlunder, T. Schmidt, A. Schneider, S. Schoenen, S. Schöneberg, L. Schumacher, D. Seckel, S. Seunarine, D. Soldin, M. Song, G. M. Spiczak, C. Spiering, J. Stachurska, T. Stanev, A. Stasik, J. Stettner, A. Steuer, T. Stezelberger, R. G. Stokstad, A. Stößl, N. L. Strotjohann, G. W. Sullivan, M. Sutherland, I. Taboada, J. Tatar, F. Tenholt, S. Ter-Antonyan, A. Terliuk, G. Tešić, S. Tilav, P. A. Toale, M. N. Tobin, S. Toscano, D. Tosi, M. Tselengidou, C. F. Tung, A. Turcati, C. F. Turley, B. Ty, E. Unger, M. Usner, J. Vandenbroucke, W. Van Driessche, N. van Eijndhoven, S. Vanheule, J. van Santen, M. Vehring, E. Vogel, M. Vraeghe, C. Walck, A. Wallace, M. Wallraff, F. D. Wandler, N. Wandkowsky, A. Waza, C. Weaver, M. J. Weiss, C. Wendt, S. Westerhoff, B. J. Whelan, S. Wickmann, K. Wiebe, C. H. Wiebusch, L. Wille, D. R. Williams, L. Wills, M. Wolf, J. Wood, T. R. Wood, E. Woolsey, K. Woschnagg, D. L. Xu, X. W. Xu, Y. Xu, J. P. Yanez, G. Yodh, S. Yoshida, T. Yuan, and M. Zoll

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We present a search for a neutrino signal from dark matter self-annihilations in the Milky Way using the IceCube Neutrino Observatory (IceCube). In 1005 days of data we found no significant excess of neutrinos over the background of neutrinos produced in atmospheric air showers from cosmic ray interactions. We derive upper limits on the velocity averaged product of the dark matter self-annihilation cross section and the relative velocity of the dark matter particles $$\langle \sigma _{\text {A}}v\rangle $$ ⟨ σ A v ⟩ . Upper limits are set for dark matter particle candidate masses ranging from 10 GeV up to 1 TeV while considering annihilation through multiple channels. This work sets the most stringent limit on a neutrino signal from dark matter with mass between 10 and 100 GeV, with a limit of $$1.18\cdot 10^{-23}\text { cm}^3\text {s}^{-1}$$ 1.18 · 10 - 23 cm 3 s - 1 for 100 GeV dark matter particles self-annihilating via $$\tau ^+\tau ^-$$ τ + τ - to neutrinos (assuming the Navarro–Frenk–White dark matter halo profile).

Published
2017
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7. Search for annihilating dark matter in the Sun with 3 years of IceCube data

Author

M. G. Aartsen, M. Ackermann, J. Adams, J. A. Aguilar, M. Ahlers, M. Ahrens, D. Altmann, K. Andeen, T. Anderson, I. Ansseau, G. Anton, M. Archinger, C. Argüelles, J. Auffenberg, S. Axani, X. Bai, S. W. Barwick, V. Baum, R. Bay, J. J. Beatty, J. Becker Tjus, K.-H. Becker, S. BenZvi, D. Berley, E. Bernardini, A. Bernhard, D. Z. Besson, G. Binder, D. Bindig, M. Bissok, E. Blaufuss, S. Blot, C. Bohm, M. Börner, F. Bos, D. Bose, S. Böser, O. Botner, J. Braun, L. Brayeur, H.-P. Bretz, S. Bron, A. Burgman, T. Carver, M. Casier, E. Cheung, D. Chirkin, A. Christov, K. Clark, L. Classen, S. Coenders, G. H. Collin, J. M. Conrad, D. F. Cowen, R. Cross, M. Day, J. P. A. M. de André, C. De Clercq, E. del Pino Rosendo, H. Dembinski, S. De Ridder, P. Desiati, K. D. de Vries, G. de Wasseige, M. de With, T. DeYoung, J. C. Díaz-Vélez, V. di Lorenzo, H. Dujmovic, J. P. Dumm, M. Dunkman, B. Eberhardt, T. Ehrhardt, B. Eichmann, P. Eller, S. Euler, P. A. Evenson, S. Fahey, A. R. Fazely, J. Feintzeig, J. Felde, K. Filimonov, C. Finley, S. Flis, C.-C. Fösig, A. Franckowiak, E. Friedman, T. Fuchs, T. K. Gaisser, J. Gallagher, L. Gerhardt, K. Ghorbani, W. Giang, L. Gladstone, T. Glauch, T. Glüsenkamp, A. Goldschmidt, J. G. Gonzalez, D. Grant, Z. Griffith, C. Haack, A. Hallgren, F. Halzen, E. Hansen, T. Hansmann, K. Hanson, D. Hebecker, D. Heereman, K. Helbing, R. Hellauer, S. Hickford, J. Hignight, G. C. Hill, K. D. Hoffman, R. Hoffmann, K. Hoshina, F. Huang, M. Huber, K. Hultqvist, S. In, A. Ishihara, E. Jacobi, G. S. Japaridze, M. Jeong, K. Jero, B. J. P. Jones, W. Kang, A. Kappes, T. Karg, A. Karle, U. Katz, M. Kauer, A. Keivani, J. L. Kelley, A. Kheirandish, J. Kim, M. Kim, T. Kintscher, J. Kiryluk, T. Kittler, S. R. Klein, G. Kohnen, R. Koirala, H. Kolanoski, R. Konietz, L. Köpke, C. Kopper, S. Kopper, D. J. Koskinen, M. Kowalski, K. Krings, M. Kroll, G. Krückl, C. Krüger, J. Kunnen, S. Kunwar, N. Kurahashi, T. Kuwabara, M. Labare, J. L. Lanfranchi, M. J. Larson, F. Lauber, D. Lennarz, M. Lesiak-Bzdak, M. Leuermann, L. Lu, J. Lünemann, J. Madsen, G. Maggi, K. B. M. Mahn, S. Mancina, M. Mandelartz, R. Maruyama, K. Mase, R. Maunu, F. McNally, K. Meagher, M. Medici, M. Meier, A. Meli, T. Menne, G. Merino, T. Meures, S. Miarecki, T. Montaruli, M. Moulai, R. Nahnhauer, U. Naumann, G. Neer, H. Niederhausen, S. C. Nowicki, D. R. Nygren, A. Obertacke Pollmann, A. Olivas, A. O’Murchadha, T. Palczewski, H. Pandya, D. V. Pankova, P. Peiffer, Ö. Penek, J. A. Pepper, C. Pérez de los Heros, D. Pieloth, E. Pinat, P. B. Price, G. T. Przybylski, M. Quinnan, C. Raab, L. Rädel, M. Rameez, K. Rawlins, R. Reimann, B. Relethford, M. Relich, E. Resconi, W. Rhode, M. Richman, B. Riedel, S. Robertson, M. Rongen, C. Rott, T. Ruhe, D. Ryckbosch, D. Rysewyk, L. Sabbatini, S. E. Sanchez Herrera, A. Sandrock, J. Sandroos, S. Sarkar, K. Satalecka, P. Schlunder, T. Schmidt, S. Schoenen, S. Schöneberg, L. Schumacher, D. Seckel, S. Seunarine, D. Soldin, M. Song, G. M. Spiczak, C. Spiering, T. Stanev, A. Stasik, J. Stettner, A. Steuer, T. Stezelberger, R. G. Stokstad, A. Stößl, R. Ström, N. L. Strotjohann, G. W. Sullivan, M. Sutherland, H. Taavola, I. Taboada, J. Tatar, F. Tenholt, S. Ter-Antonyan, A. Terliuk, G. Tešić, S. Tilav, P. A. Toale, M. N. Tobin, S. Toscano, D. Tosi, M. Tselengidou, A. Turcati, E. Unger, M. Usner, J. Vandenbroucke, N. van Eijndhoven, S. Vanheule, M. van Rossem, J. van Santen, M. Vehring, M. Voge, E. Vogel, M. Vraeghe, C. Walck, A. Wallace, M. Wallraff, N. Wandkowsky, Ch. Weaver, M. J. Weiss, C. Wendt, S. Westerhoff, B. J. Whelan, S. Wickmann, K. Wiebe, C. H. Wiebusch, L. Wille, D. R. Williams, L. Wills, M. Wolf, T. R. Wood, E. Woolsey, K. Woschnagg, D. L. Xu, X. W. Xu, Y. Xu, J. P. Yanez, G. Yodh, S. Yoshida, and M. Zoll

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We present results from an analysis looking for dark matter annihilation in the Sun with the IceCube neutrino telescope. Gravitationally trapped dark matter in the Sun’s core can annihilate into Standard Model particles making the Sun a source of GeV neutrinos. IceCube is able to detect neutrinos with energies >100 GeV while its low-energy infill array DeepCore extends this to >10 GeV. This analysis uses data gathered in the austral winters between May 2011 and May 2014, corresponding to 532 days of livetime when the Sun, being below the horizon, is a source of up-going neutrino events, easiest to discriminate against the dominant background of atmospheric muons. The sensitivity is a factor of two to four better than previous searches due to additional statistics and improved analysis methods involving better background rejection and reconstructions. The resultant upper limits on the spin-dependent dark matter-proton scattering cross section reach down to $$1.46\times 10^{-5}$$ 1.46×10-5 pb for a dark matter particle of mass 500 GeV annihilating exclusively into $$\tau ^{+}\tau ^{-}$$ τ+τ- particles. These are currently the most stringent limits on the spin-dependent dark matter-proton scattering cross section for WIMP masses above 50 GeV.

Published
2017
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9. Observed climate trends in Europe 1891-1990

Author

C.-D. Schönwiese, J. Rapp, T. Fuchs, and M. Denhard

Subjects
european climate trend atlas, air temperature, air pressure, 'kriging' interpolation scheme, trend-to-noise ratios, europäischer klimatrend-atlas, lufttemperatur, luftdruck, "kriging"-interpolationsschema, trend-/rauschverhältnisse, Meteorology. Climatology, QC851-999
Abstract

Kürzlich ist ein "Europäischer Klimatrend-Atlas 1891-1990" veröffentlicht worden. Dieser Atlas zeigt die linearen Trends der Lufttemperatur (Bodennähe), des Niederschlages und des Luftdrucks, wie sie in den einheitlichen Zeitintervallen 1891-1990 bzw. 1961-1990 beobachtet worden sind. Zusätzlich sind die Luftfeuchte-Trends 1961-1990 angegeben. Die Analyse beruht auf (maximal) 117 Stationsdatenreihen, die hinsichtlich ihrer Homogenität überprüft worden sind. Die Berechnung der Trendkarten erfolgte mit Hilfe des "Kriging"-Interpolationsschemas unter Verwendung eines 3° x 3°-Gitters. Trend-/Rauschverhältnisse und Mann-Kendall-Trendtests sind in die Analyse eingeschlossen. Die Ergebnisse offenbaren bemerkenswert unterschiedliche Trends in den verschiedenen Monaten und Regionen. Dieser kurze Beitrag konzentriert sich auf jahreszeitliche Änderungen von Temperatur und Niederschlag, wobei Langfristtrends (1891-1990) steigender Temperatur und relativ kurzfristige Trends (1961-1990) abnehmenden Sommer-Niederschlags, wie sie sich in einigen Teilbereichen Europas abzeichnen, besonders hervortreten.

Published
1994
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12. Classifying and inferring behaviors using real‐time acceleration biotelemetry in reproductive steelhead trout (Oncorhynchus mykiss)

Author

Nathaniel T. Fuchs and Christopher C. Caudill

Subjects
accelerometer, biotelemetry, intragastric, radio telemetry, steelhead spawning, Ecology, QH540-549.5
Abstract

Abstract Movement behaviors are central to ecology and conservation. Movement sensing technologies can monitor behaviors that are otherwise difficult to observe under field conditions and may enhance the ability to quantify behaviors at the population scale. We monitored steelhead trout (Oncorhynchus mykiss) spawning behaviors in a seminatural enclosure using accelerometer telemetry tags while simultaneously observing behaviors with underwater cameras. Behavioral assignments from visual observations were compared to acceleration histories to develop assignment criteria for acceleration data, including for a key behavior (oviposition). Behavioral events independently classified using acceleration data prior to reviewing video were compared to video scoring and 97% of holding behaviors, 93% of digging behaviors, and 86% of oviposition/covering behaviors were correctly assigned using acceleration data alone. We applied the method to at‐liberty steelhead in spawning tributaries. Acceleration records revealed putative spawning and oviposition in at‐liberty female steelhead, and time budgets for at‐liberty steelhead were similar to those monitored within enclosures. The use of similar movement sensing tags and classification approaches offers a method for monitoring movement behavior, activity budgets, and habitat use in a broad array of aquatic and terrestrial taxa, and may be especially useful when behaviors are cryptic.

Published
2019
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17. ProteomicsDB: toward a FAIR open-source resource for life-science research

Author

Ludwig Lautenbacher, Patroklos Samaras, Julian Muller, Andreas Grafberger, Marwin Shraideh, Johannes Rank, Simon T Fuchs, Tobias K Schmidt, Matthew The, Christian Dallago, Holger Wittges, Burkhard Rost, Helmut Krcmar, Bernhard Kuster, and Mathias Wilhelm

Subjects
Proteomics, Application programming interface, AcademicSubjects/SCI00010, Interface (Java), Interoperability, Proteins, Findability, Biology, Pipeline (software), Biological Science Disciplines, Market fragmentation, World Wide Web, Resource (project management), Genetics, Database Issue, Humans, Neural Networks, Computer, User interface, Databases, Protein, Software
Abstract

ProteomicsDB (https://www.ProteomicsDB.org) is a multi-omics and multi-organism resource for life science research. In this update, we present our efforts to continuously develop and expand ProteomicsDB. The major focus over the last two years was improving the findability, accessibility, interoperability and reusability (FAIR) of the data as well as its implementation. For this purpose, we release a new application programming interface (API) that provides systematic access to essentially all data in ProteomicsDB. Second, we release a new open-source user interface (UI) and show the advantages the scientific community gains from such software. With the new interface, two new visualizations of protein primary, secondary and tertiary structure as well an updated spectrum viewer were added. Furthermore, we integrated ProteomicsDB with our deep-neural-network Prosit that can predict the fragmentation characteristics and retention time of peptides. The result is an automatic processing pipeline that can be used to reevaluate database search engine results stored in ProteomicsDB. In addition, we extended the data content with experiments investigating different human biology as well as a newly supported organism.

Published
2021

19. Preparation and Motivation of High School Students Who Want to Become Science or Mathematics Teachers

Author

Chen Chen, Travis T. Fuchs, Philip M. Sadler, Sandra A. Scott, and Gerhard Sonnert

Subjects
Medical education, 4. Education, 05 social sciences, 050401 social sciences methods, 050301 education, Economic shortage, Science teachers, Science education, Education, 0504 sociology, Intervention (counseling), ComputingMilieux_COMPUTERSANDEDUCATION, School level, 0503 education
Abstract

Shortages of science and mathematics teachers are a serious concern in the United States. Despite the implementation of intervention strategies to address this problem at the high school level, lit...

Published
2021

20. Overwintering Distribution and Postspawn Survival of Steelhead in the Upper Columbia River Basin

Author

Christopher C. Caudill, Nathaniel T. Fuchs, Andrew R. Murdoch, and Benjamin L. Truscott

Subjects
Hydrology, geography, geography.geographical_feature_category, Ecology, business.industry, Drainage basin, Distribution (economics), Management, Monitoring, Policy and Law, Aquatic Science, business, Ecology, Evolution, Behavior and Systematics, Overwintering, Geology
Published
2021

21. Development of a Cas12a-Based Genome Editing Tool for Moderate Thermophiles

Author

Justin Albers, Megumu Mabuchi, Ryan T. Fuchs, Prarthana Mohanraju, Richard van Kranenburg, Jennifer L. Curcuru, Ioannis Mougiakos, G. Brett Robb, and John van der Oost

Subjects
CRISPR-Associated Proteins, Mutant, Bacillus, Bacterial genome size, Computational biology, Biology, medicine.disease_cause, Microbiology, Genome engineering, Bacterial Proteins, Genome editing, Microbiologie, Escherichia coli, Genetics, medicine, Life Science, Clustered Regularly Interspaced Short Palindromic Repeats, Francisella novicida, Francisella, Research Articles, VLAG, Gene Editing, Recombination, Genetic, Endodeoxyribonucleases, Thermophile, BacGen, Endonucleases, CRISPR-Cas Systems, Homologous recombination, Genome, Bacterial, Function (biology), Plasmids, Biotechnology
Abstract

The ability of CRISPR-Cas12a nucleases to function reliably in a wide range of species has been key to their rapid adoption as genome engineering tools. However, so far, Cas12a nucleases have been limited for use in organisms with growth temperatures up to 37 °C. Here, we biochemically characterize three Cas12a orthologs for their temperature stability and activity. We demonstrate that Francisella novicida Cas12a (FnCas12a) has great biochemical potential for applications that require enhanced stability, including use at temperatures >37°C. Furthermore, by employing the moderate thermophilic bacterium Bacillus smithii as our experimental platform, we demonstrate that FnCas12a is active in vivo at temperatures up to 43°C. Subsequently, we develop a single-plasmid FnCas12a-based genome editing tool for B. smithii, combining the FnCas12a targeting system with plasmid-borne homologous recombination (HR) templates that carry the desired modifications. Culturing of B. smithii cells at 45°C allows for the uninhibited realization of the HR-based editing step, while a subsequent culturing step at reduced temperatures induces the efficient counterselection of the non-edited cells by FnCas12a. The developed gene-editing tool yields gene-knockout mutants within 3 days, and does not require tightly controllable expression of FnCas12a to achieve high editing efficiencies, indicating its potential for other (thermophilic) bacteria and archaea, including those with minimal genetic toolboxes. Altogether, our findings provide new biochemical insights into three widely used Cas12a nucleases, and establish the first Cas12a-based bacterial genome editing tools for moderate thermophilic microorganisms.

Published
2021

22. Leveraging Student Misconceptions to Improve Teaching of Biochemistry & Cell Biology

Author

Mike Arsenault, Kevin M. Bonney, and Travis T. Fuchs

Subjects
0303 health sciences, Evidence-based practice, Teaching method, Reflective practice, 030303 biophysics, 05 social sciences, 050301 education, Plan (drawing), Agricultural and Biological Sciences (miscellaneous), Education, 03 medical and health sciences, Educational research, Resource (project management), Concept learning, ComputingMilieux_COMPUTERSANDEDUCATION, Learning theory, Engineering ethics, General Agricultural and Biological Sciences, 0503 education
Abstract

Students come to science class with many ideas of how the natural world works, some of which do not match the consensus of the scientific community and can lead to misunderstandings. Because a growing body of educational research indicates that these misconceptions can serve as resources for learning, we developed a four-point plan to leverage knowledge of common misconceptions to improve classroom teaching by refining instructional focus, providing opportunities for reflective practice, applying evidence-based practices, and promoting exploration of learning theories. By sharing this plan with our teaching colleagues, we were able to foster a collaborative approach to our and others’ practice. To do this, we compiled a resource bank of common student misconceptions using data collected from the University of Toronto’s National Biology Competition, developed a guide for using this misconception resource bank to promote best teaching practices, then shared this plan with our teaching colleagues in order to foster a collaborative approach to our pedagogy. In this article, we present the resource bank and guide and provide teaching tips that can be applied to a wide array of scientific course types and educational levels.

Published
2021

23. Characterization of Cme and Yme thermostable Cas12a orthologs

Author

Ryan T. Fuchs, Jennifer L. Curcuru, Megumu Mabuchi, Audrey Noireterre, Peter R. Weigele, Zhiyi Sun, and G. Brett Robb

Subjects
Medicine (miscellaneous), General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology
Abstract

CRISPR-Cas12a proteins are RNA-guided endonucleases that cleave invading DNA containing target sequences adjacent to protospacer adjacent motifs (PAM). Cas12a orthologs have been repurposed for genome editing in non-native organisms by reprogramming them with guide RNAs to target specific sites in genomic DNA. After single-turnover dsDNA target cleavage, multiple-turnover, non-specific single-stranded DNA cleavage in trans is activated. This property has been utilized to develop in vitro assays to detect the presence of specific DNA target sequences. Most applications of Cas12a use one of three well-studied enzymes. Here, we characterize the in vitro activity of two previously unknown Cas12a orthologs. These enzymes are active at higher temperatures than widely used orthologs and have subtle differences in PAM preference, on-target cleavage, and trans nuclease activity. Together, our results enable refinement of Cas12a-based in vitro assays especially when elevated temperature is desirable.

Published
2022

24. Preliminary Improvements in Dynamic Postural Control after A Group-based Intervention Program for Children with Developmental Coordination Disorder: A Brief Report

Author

Chadwick T. Fuchs, Haylie L. Miller, Priscila Tamplain, and Gabriela M. Sherrod

Subjects
Male, Dynamic postural control, 030506 rehabilitation, medicine.medical_specialty, Group based, Article, Postural control, 03 medical and health sciences, Physical medicine and rehabilitation, Developmental Neuroscience, Intervention (counseling), medicine, Humans, 0501 psychology and cognitive sciences, Child, Postural Balance, Balance (ability), Intervention program, 05 social sciences, Rehabilitation, General Medicine, Exercise Therapy, Motor Skills Disorders, Pediatrics, Perinatology and Child Health, Psychotherapy, Group, Female, 0305 other medical science, Psychology, 050104 developmental & child psychology
Abstract

OBJECTIVE: To determine the value of a traditional (easy to implement) group-based intervention program on both static and dynamic postural control in children with Developmental Coordination Disorder (DCD). METHODS: Sway and stability indices were measured with the Clinical Test of Sensory Integration in Balance (CTSIB) and efficiency of goal-directed movement was measured during a Limits-of-Stability (LoS) task, before and after the intervention program. The intervention involved a total of 10 one-hour group sessions, administered once per week for 10 weeks. RESULTS: Results indicated significant group increases in dynamic postural control (p < .05). These results suggest it is possible to improve dynamic postural control in this population. This type of intervention does not require any expensive materials, it is feasible, and easy-to-implement to a group of children. CONCLUSION: We conclude that this simple form of intervention involving fun group activities can significantly improve dynamic postural control in children with DCD.

Published
2020

25. Accuracy and Vividness in Motor Imagery Ability: Differences between Children and Young Adults

Author

Priscila Tamplain, Chadwick T. Fuchs, Kevin A. Becker, and Erin Austin

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, 05 social sciences, 050105 experimental psychology, Young Adult, 03 medical and health sciences, Motor task, 0302 clinical medicine, Neuropsychology and Physiological Psychology, Motor imagery, Physical medicine and rehabilitation, Imagination, Developmental and Educational Psychology, medicine, Humans, Female, 0501 psychology and cognitive sciences, Young adult, Psychology, Psychomotor Performance, 030217 neurology & neurosurgery
Abstract

Motor imagery (MI) refers to the imagination of a motor task without actual movement execution. The purpose of this study was to compare MI accuracy and vividness, and motor proficiency between children (

Published
2020

26. Evaluation of the Efficacy and Safety of Neostigmine in Reversing Neuromuscular Blockade

Author

P. Bernard, T. Fuchs-Buder, R. Sghaier, and Denis Schmartz

Subjects
Neuromuscular Blockade, medicine.medical_specialty, business.industry, Spontaneous recovery, 030208 emergency & critical care medicine, Sugammadex, Neostigmine, 03 medical and health sciences, 0302 clinical medicine, Anesthesiology and Pain Medicine, 030202 anesthesiology, Anesthesia, Anesthesiology, medicine, Adverse effect, business, medicine.drug
Abstract

The minimum degree of neuromuscular recovery required before extubating the patient has progressively increased from a train-of-four ratio of 0.7 to a train-of-four ratio ≥ 0.9. The aim of the review is to evaluate the efficacy and the safety of neostigmine in antagonizing nondepolarizing neuromuscular block considering the new endpoint. Increasing evidence suggests limited efficacy of neostigmine when a TOF ratio ≥ 0.9 is considered as appropriate endpoint. The currently accepted endpoint of adequate neuromuscular recovery challenges the efficacy of neostigmine. At least under volatile anesthesia, neostigmine can no longer be considered as an efficient drug to reverse moderate neuromuscular blockade, but it still allows to accelerate neuromuscular recovery when given at more advanced degrees of spontaneous recovery (i.e., a TOF ratio ≥ 0.4). Moreover, neostigmine-based reversal is associated with a higher incidence of adverse effects compared with sugammadex.

Published
2020

27. Geothermal Rapid Screening

Author

A. Parent, C. Vogt, C. Bonomi, T. Fuchs, R. Schulze-Riegert, F. Krzikalla, M. Carles, and B. Lipinski

Published
2022

29. Establishment of a reliable in-vivo model of implant-associated infection to investigate innovative treatment options

Author

C, Kreis, F K, Aschenbrenner, D, Günther, N, Tholema-Hans, J, Koeppe, S B, Rosslenbroich, M J, Raschke, and T, Fuchs

Subjects
Postoperative Complications, Animals, Reproducibility of Results, Osteomyelitis, Gentamicins, Staphylococcal Infections, Anti-Bacterial Agents, Rats
Abstract

The increasing number of implant-associated infections and of multiresistant pathogens is a major problem in the daily routine. In the field of osteomyelitis, it is difficult to manage a valid clinical study because of multiple influencing factors. Therefore, models of osteomyelitis with a simulation of the pathophysiology to evaluate treatment options for implant-associated infections are necessary. The aim of this study is to develop a standardized and reproducible osteomyelitis model in-vivo to improve treatment options. This study analyses the influence of a post-infectious implant exchange one week after infection and the infection progress afterward in combination with a systemic versus a local antibiotic treatment in-vivo. Therefore, the implant exchange, the exchange to a local drug-delivery system with gentamicin, and the implant removal are examined. Furthermore, the influence of an additional systemic antibiotic therapy is evaluated. An in-vivo model concerning the implant exchange is established that analyzes clinic, radiologic, microbiologic, histologic, and immunohistochemical diagnostics to obtain detailed evaluation and clinical reproducibility. Our study shows a clear advantage of the combined local and systemic antibiotic treatment in contrast to the implant removal and to a non-combined antibiotic therapy. Group genta/syst. showed the lowest infection rate with a percentage of 62.5% concerning microbiologic analysis, which is in accordance with the immunohistochemical, cytochemical, histologic, and radiologic analysis. Our in-vivo rat model has shown valid and reproducible results, which will lead to further investigations regarding treatment options and influencing factors concerning the therapy of osteomyelitis and implant-associated infections.

Published
2021

31. Classifying and inferring behaviors using real‐time acceleration biotelemetry in reproductive steelhead trout (Oncorhynchus mykiss)

Author

Christopher C. Caudill and Nathaniel T. Fuchs

Subjects
0106 biological sciences, Population, biotelemetry, Accelerometer, 010603 evolutionary biology, 01 natural sciences, 03 medical and health sciences, Acceleration, lcsh:QH540-549.5, Telemetry, education, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Nature and Landscape Conservation, Biotelemetry, Original Research, 0303 health sciences, education.field_of_study, Ecology, biology, intragastric, biology.organism_classification, steelhead spawning, Fishery, Trout, Digging, accelerometer, Rainbow trout, lcsh:Ecology, radio telemetry
Abstract

Movement behaviors are central to ecology and conservation. Movement sensing technologies can monitor behaviors that are otherwise difficult to observe under field conditions and may enhance the ability to quantify behaviors at the population scale. We monitored steelhead trout (Oncorhynchus mykiss) spawning behaviors in a seminatural enclosure using accelerometer telemetry tags while simultaneously observing behaviors with underwater cameras. Behavioral assignments from visual observations were compared to acceleration histories to develop assignment criteria for acceleration data, including for a key behavior (oviposition). Behavioral events independently classified using acceleration data prior to reviewing video were compared to video scoring and 97% of holding behaviors, 93% of digging behaviors, and 86% of oviposition/covering behaviors were correctly assigned using acceleration data alone. We applied the method to at‐liberty steelhead in spawning tributaries. Acceleration records revealed putative spawning and oviposition in at‐liberty female steelhead, and time budgets for at‐liberty steelhead were similar to those monitored within enclosures. The use of similar movement sensing tags and classification approaches offers a method for monitoring movement behavior, activity budgets, and habitat use in a broad array of aquatic and terrestrial taxa, and may be especially useful when behaviors are cryptic., Movement behaviors are central to ecology and conservation, and movement sensing technologies can monitor behaviors that are otherwise difficult to observe under field conditions and may enhance the ability to quantify behaviors at the population scale. We monitored steelhead trout spawning behaviors in a seminatural enclosure and in the natural environment (at‐liberty) using accelerometer telemetry tags while simultaneously observing behaviors with underwater cameras. Behavioral events independently classified using acceleration data prior to reviewing video were compared, and 97% of holding behaviors, 93% of digging behaviors, and 86% of oviposition/covering behaviors were correctly assigned for steelhead observed within the enclosure. Applying the same methods to at‐liberty steelhead, acceleration detections revealed putative spawning and oviposition behaviors.

Published
2019

32. Effekt von Humortraining auf Stress, Heiterkeit und Depression bei Patienten mit koronarer Herzkrankheit und therapierefraktärer Angina pectoris

Author

E von Hirschhausen, M Voss, B Wild, T Fuchs, and Peter Ong

Subjects
Gynecology, medicine.medical_specialty, business.industry, 030204 cardiovascular system & hematology, Coronary disease, medicine.disease, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Medicine, In patient, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business, Refractory angina
Abstract

Die therapierefraktare Angina pectoris ist in der Behandlung von Patienten mit koronarer Herzkrankheit (KHK) ein haufiges Phanomen, erzeugt einen hohen Leidensdruck und beansprucht das Gesundheitssystem in hohem Mase. Die Entwicklung neuer Therapiekonzepte ist aus diesem Grund von besonderer Bedeutung. In dieser Studie wurde untersucht, ob ein professionelles, strukturiertes Humortraining einen Effekt auf die Beschwerdesymptomatik von Patienten mit therapierefraktaren Beschwerden hat. Im Rahmen dieser Studie wurden im Zeitraum von 2013 bis 2014 insgesamt 35 Patienten mit stabiler KHK eingeschlossen. Der Studieneinschluss erfolgte bei therapierefraktaren Beschwerden (CCS[Canadian Cardiovascular Society]-Stadium II–IV) trotz maximaler antianginoser Therapie und Ausschopfung jeglicher Revaskularisationsoptionen. 25,8 % der Patienten hatten einen Myokardinfarkt in der Vorgeschichte. Im Rahmen der Studie erfolgte ein professionelles Humortraining uber 7 Wochen. Zur Beurteilung des Effekts des Humortrainings wurden vorher und nachher folgende Untersuchungen durchgefuhrt: Belastungs-EKG, Haarsegmentanalyse mit Kortisolbestimmung, Beck-Depressions-Inventar(BDI)-Fragebogen, Trierer Inventar zum chronischen Stress (TICS), State-Trait-Heiterkeits-Inventar (STHI-S/T). Von 31 der ursprunglichen 35 rekrutierten Patienten wurde die Studie erfolgreich beendet. Der Altersdurchschnitt lag bei 65,5 Jahren mit 94,5 % weiblichen Probanden. Im STHI-S-Fragebogen zeigte sich im Vergleich der Daten vor und nach dem Humortraining eine signifikante Verbesserung der Erheiterbarkeit (pra: 23,3 ± 5,4, post: 27,5 ± 5; p = 0,03). Dieser Effekt war noch deutlicher bei einer Subgruppenanalyse zu sehen, in der nur die weiblichen Studienteilnehmer berucksichtigt wurden (pra: 23,6 ± 5,5, post: 27,7 ± 4,6; p = 0,003). Im BDI zeigte sich im Vergleich der Daten vor und nach dem Humortraining eine deutliche Verbesserung (pra: 14,6 ± 8,1, post: 11,0 ± 6,5; p = 0,064). Diese war bei Analyse der 29 Frauen statistisch signifikant (pra: 13,1 ± 6,4, post: 9,9 ± 4,6; p = 0,037). Die Haarsegmentanalyse ergab bei Probanden mit erhohten Werten vor dem Humortraining (>25. Perzentile, n = 22) eine signifikante Reduktion der Haarkortisolkonzentration (pra: 6,54 [3,78–12,12] pg/mg, post: 3,65 [2,82–7,68] pg/mg; p = 0,029). Patienten mit therapierefraktarer Angina pectoris bei KHK profitieren von einem professionellen Humortraining. Dies konnte durch einen signifikanten Abfall der Kortisolkonzentration in der Haarsegmentanalyse, eine Verbesserung in der Erheiterbarkeit im STHI-S sowie eine signifikante Verbesserung im BDI gezeigt werden.

Published
2019

33. Using a handwriting app leads to improvement in manual dexterity in kindergarten children

Author

Priscila Caçola, Jodi Tommerdahl, Ricardo de Almeida Pimenta, Chadwick T. Fuchs, and Christi Butler

Subjects
medicine.medical_specialty, manual dexterity, Teaching method, education, school-age children, Audiology, Legibility, Computer Science Applications, Education, iPad, Handwriting, medicine, kindergarten, Psychology, lcsh:L, app, Fine motor, handwriting, lcsh:Education
Abstract

This study aimed to determine the effectiveness of using electronic handwriting applications (apps) in addition to a traditional method of teaching handwriting on kindergarten children’s manual dexterity (MD) and handwriting skills. Testing was done with 125 children in two groups: control (n = 67) and experimental (n = 58). Both groups used worksheets, but the experimental group also used an app with a stylus for their practice time. A 2 (group) × 2 (time) analysis indicated a significant interaction for MD (p < 0.03), with a significant improvement in the experimental group. Significant differences emerged for legibility, showing that both groups improved at handwriting over time. Study results demonstrated that using apps in the kindergarten classroom can enhance handwriting as well as a traditional handwriting teaching method. Apps also have the advantage of improving MD, which is a building block for several fine motor skills.

Published
2019

34. The Wootton center for astrophysical plasma properties: First results for helium

Author

M.-A. Schaeuble, J. T. Fuchs, B. H. Dunlap, Don Winget, and Michael H. Montgomery

Subjects
Physics, Supermassive black hole, Astrophysics::High Energy Astrophysical Phenomena, White dwarf, chemistry.chemical_element, Astronomy and Astrophysics, Astrophysics, Plasma, 01 natural sciences, Spectral line, 010305 fluids & plasmas, Neon, chemistry, Space and Planetary Science, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, Astrophysical plasma, Astrophysics::Earth and Planetary Astrophysics, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Helium, Line (formation)
Abstract

The Wootton Center for Astrophysical Plasma Properties (WCAPP) is a new center focusing on the spectroscopic properties of stars and accretion disks using “at-parameter” experiments. Currently, these experiments use the X-ray output of the Z machine at Sandia National Laboratories — the largest X-ray source in the world — to heat plasmas to the same conditions (temperature, density, and radiation environment) as those observed in astronomical objects. The experiments include measuring (1) density-dependent opacities of iron-peak elements at solar interior conditions, (2) spectral lines of low-Z elements at white dwarf photospheric conditions, (3) atomic population kinetics of neon in a radiation-dominated environment, and (4) resonant Auger destruction (RAD) of silicon at conditions found in accretion disks around supermassive black holes. In particular, we report on recent results of our experiments involving helium at white dwarf photospheric conditions. We present results showing disagreement between inferred electron densities using the Hβ line and the He I 5876 Å line, most likely indicating incompleteness in our modeling of this helium line.

Published
2019

35. 43/w mit laparoskopischer Hysterektomie

Author

T. Fuchs-Buder

Subjects
medicine.medical_specialty, Anesthesiology and Pain Medicine, business.industry, Pain medicine, General surgery, Anesthesiology, medicine, General Medicine, business
Published
2019

38. Characterization of Cme and Yme thermostable Cas12a orthologs

Author

Ryan T, Fuchs, Jennifer L, Curcuru, Megumu, Mabuchi, Audrey, Noireterre, Peter R, Weigele, Zhiyi, Sun, and G Brett, Robb

Subjects
Nucleic Acid Conformation, DNA, CRISPR-Cas Systems, DNA Cleavage, RNA, Guide, Kinetoplastida
Abstract

CRISPR-Cas12a proteins are RNA-guided endonucleases that cleave invading DNA containing target sequences adjacent to protospacer adjacent motifs (PAM). Cas12a orthologs have been repurposed for genome editing in non-native organisms by reprogramming them with guide RNAs to target specific sites in genomic DNA. After single-turnover dsDNA target cleavage, multiple-turnover, non-specific single-stranded DNA cleavage in trans is activated. This property has been utilized to develop in vitro assays to detect the presence of specific DNA target sequences. Most applications of Cas12a use one of three well-studied enzymes. Here, we characterize the in vitro activity of two previously unknown Cas12a orthologs. These enzymes are active at higher temperatures than widely used orthologs and have subtle differences in PAM preference, on-target cleavage, and trans nuclease activity. Together, our results enable refinement of Cas12a-based in vitro assays especially when elevated temperature is desirable.

Published
2021

39. Women Writers’ Philosophy of Love in German Romanticism : Dialogical Life in Letters

Author

Renata T. Fuchs and Renata T. Fuchs

Abstract

This monograph spotlights women writers'contributions to the philosophy of German Romanticism. Dorothea Mendelssohn Veit Schlegel, Rahel Levin Varnhagen, Karoline von Günderrode, and Bettina Brentano von Arnim suggested a new vision for an emancipated community of women that develops through philosophical discourse of Progressive Universal Poetry. Their personal, fictionalized, and literary letters reinvent and retheorize the Romantic notions of sociability, symphilosophy, and sympoetry, as theorized by men, and retheorize the concepts of love. They provided a model for shaping intellectual and cultural life in the modern world while challenging rigid dichotomies of classs, gender, and ethnicity.

Published
2024

45. Nachspann

Author

Werner T. Fuchs

Published
2021

46. Vorspann

Author

Werner T. Fuchs

Published
2021

50. Der Autor

Author

Werner T. Fuchs

Published
2021

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