22 results on '"T. Dufresne"'
Search Results
2. Advanced approach to the maintenance of hydraulic and turbine oils
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Peter T. Dufresne, Hobbs Matthew, and Janez Tomažin
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Petroleum engineering ,Environmental science ,ComputerApplications_COMPUTERSINOTHERSYSTEMS ,Turbine - Abstract
In the growing power demands, turbine users want to feel confident that their equipment is reliable, efficient, and delivering peak performance every day. Proper care and maintenance of turbine oils is critical to avoiding disruptive and potentially costly downtime, and can help extend oil and component life. The ISO 55001 Asset Management and EN 17485 Maintenance within Physical Asset Management: “Framework for improving the value of the physical assets through their whole life cycle” provides an opportunity for companies to review and improve asset owner and service provider relationships, improve performance and utilisation of assets, reduce operational risk arising from the various stages of asset management and reduce the cost of insurance and ensure regulatory compliance. With such an approach and the use of the best available technology, turbine oil is becoming an asset. This article focuses on turbine oils quality, their degradation, additives and, varnish removal.
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- 2021
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3. Inefficient Codon Usage Impairs mRNA Accumulation: the Case of the v-FLIP Gene of Kaposi's Sarcoma-Associated Herpesvirus
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Don Ganem, Andrew T. Dufresne, and Priya Bellare
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Translational efficiency ,RNA Stability ,Immunology ,Gene Expression ,Biology ,medicine.disease_cause ,Microbiology ,Cell Line ,Viral Proteins ,Virology ,Gene expression ,medicine ,Humans ,RNA, Messenger ,Kaposi's sarcoma-associated herpesvirus ,Codon ,Gene ,Genetics ,Messenger RNA ,Expression vector ,NF-kappa B ,RNA ,Genome Replication and Regulation of Viral Gene Expression ,Cell biology ,Insect Science ,Codon usage bias ,Herpesvirus 8, Human ,Host-Pathogen Interactions - Abstract
Latent Kaposi's sarcoma-associated herpesvirus (KSHV) genomes encode a homolog of cellular FLICE-inhibitory proteins (termed v-FLIP) that activates NF-κB and can trigger important proinflammatory and antiapoptotic changes in latently infected cells. The protein is present at very low levels in infection and has generally been difficult to efficiently express in recombinant vectors. Here we show that codon usage in the v-FLIP gene is strikingly suboptimal. Optimization of codon use in expression vectors, as expected, restores efficient protein expression. Surprisingly, however, it also dramatically increases the steady-state level of v-FLIP mRNA, at least in part by increasing mRNA stability. When codon-optimized v-FLIP sequences are reintroduced into intact KSHV genomes, the resulting virus expresses readily detectable monocistronic v-FLIP mRNAs that are undetectable in wild-type (WT) infection by blot hybridization, suggesting that such RNAs are in fact transcribed in WT infection but fail to accumulate. The overexpression of v-FLIP by codon-optimized latent genomes results in a 5- to 7-fold decrement in virus production following lytic induction, indicating that maximizing NF-κB signaling is deleterious to induction. These studies provide a clear explanation for the evolution of inefficient codon usage in this gene and point to a strong connection between translational efficiency and RNA accumulation in mammalian cells. IMPORTANCE This study reports that inefficient codon usage in a herpesviral gene is strikingly correlated with the inability of its mRNA to accumulate in cells; correction of efficient translatability restores RNA abundance. A similar correlation has been reported in yeast species, but the mechanisms operating in mammalian cells appear substantially different.
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- 2015
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4. Adaptation of an ICAM-1-Tropic Enterovirus to the Mouse Respiratory Tract
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Eric S. Wang, Elena Y. Dobrikova, Christian Goetz, Matthias Gromeier, and Andrew T. Dufresne
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Genetically modified mouse ,Virus genetics ,viruses ,Respiratory System ,Immunology ,Coxsackievirus A21 ,Adaptation, Biological ,Mice, Transgenic ,Genome, Viral ,Biology ,medicine.disease_cause ,Microbiology ,Mice ,Serial passage ,Virology ,medicine ,Animals ,Humans ,Tropism ,Enterovirus ,Intercellular Adhesion Molecule-1 ,Viral Tropism ,Viral replication ,Insect Science ,Tissue tropism ,RNA, Viral ,Receptors, Virus ,Pathogenesis and Immunity - Abstract
Respiratory tract (RT) infections by members of the enterovirus (EV) genus of the Picornaviridae family are the most frequent cause for the common cold and a major factor in the exacerbation of chronic pulmonary diseases. The lack of a practical small-animal model for these infections has obstructed insight into pathogenic mechanisms of the common cold and their role in chronic RT illness and has hampered preclinical evaluation of antiviral strategies. Despite significant efforts, it has been difficult to devise rodent models that exhibit viral replication in the RT. This is due mainly to well-known intracellular host restrictions of EVs with RT tropism in rodent cells. We report the evolution of variants of the common-cold-causing coxsackievirus A21, an EV with tropism for the human intercellular adhesion molecule 1 (hICAM-1), through serial passage in the lungs of mice transgenic for the hICAM-1 gene. This process was accompanied by multiple changes in the viral genome, suggesting exquisite adaptation of hICAM-1-tropic enteroviruses to the specific growth conditions within the RT. In vivo mouse RT-adapted, variant coxsackievirus A21 exhibited replication competence in the lungs of hICAM-1 transgenic mice, providing a basis for unraveling EV-host interactions in the mouse RT.
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- 2011
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5. Textural Characterization of Pureed Cakes Prepared for the Therapeutic Treatment of Dysphagic Patients
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N. Lachance, T. Dufresne, Hosahalli S. Ramaswamy, and N. Houjaij
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business.industry ,Therapeutic treatment ,Texture profile analysis ,medicine ,Profile analysis ,Food science ,medicine.symptom ,business ,Dysphagia ,Diet treatment ,Food Science - Abstract
Dysphagia is a difficulty in eating and swallowing of solid and/or liquid foods in elderly patients. Texture characterization of therapeutic diets for dysphagia patients has not been studied extensively. In this study, five different pureed therapeutic cakes (apple, orange, vanilla, carrot, and chocolate), previously proved efficient in the treatment of dysphagic patients, were evaluated for firmness, cohesiveness, adhesiveness, and springiness using textural profile analysis. The therapeutic cakes were tested at two serving temperatures: 12°C and 23°C. Results of sensorial tests confirmed that clinical efficiency and texture firmness of the therapeutic cakes ranged from 0.741 to 2.52 N for cakes at 12°C and from 0.608 to 2.58 N for cakes at 23°C. Similarly, cohesiveness ranged from 0.391 to 0.561 at 12°C and 0.479 to 0.568 at 23°C, adhesiveness from –0.219 to –0.436 N at 12°C and – 0.201 to –0.424 N at 23°C and finally springiness ranged from 46 to 70% at 12°C and 24 to 61% at 23°C. Non-therapeutic cakes...
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- 2009
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6. Rheological characterization of thickened beverages used in the treatment of dysphagia
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Hosahalli S. Ramaswamy, I. Germain, and T. Dufresne
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Shear thinning ,Correlation coefficient ,Chemistry ,Mineralogy ,Apparent viscosity ,Dysphagia ,Shear rate ,Thickened fluids ,Rheology ,Consistency (statistics) ,medicine ,Food science ,medicine.symptom ,Food Science - Abstract
Dysphagia is a difficulty in eating and swallowing of solid and/or liquid foods. Thickened beverages are traditionally used in the clinical treatment of dysphagia to liquids. The objectives of this study were to evaluate the rheology of clinically efficient cold thickened beverages and relate them to the consistency groups (traditionally recognized as nectar, honey and pudding). Rheological tests were carried out at the serving temperature of 8 °C using a rotational viscometer using a pre-established upward and downward shearing sequence. Rheological parameters such as consistency coefficient, flow behavior index, yield stress and apparent viscosity were computed. All beverages tested demonstrated a shear-thinning pseudoplastic flow behavior with yield stress, and were best fitted to the Herschel–Bulkley model. Yet, the correlation coefficient between the consistency coefficient and the Bostwick consistency levels (nectar, honey and pudding) was found to be poor (0.6–0.7). The apparent viscosity and the Bostwick consistency levels showed slightly better correlation coefficients (0.73–0.83). At each Bostwick consistency level, the yield stress, consistency coefficient and apparent viscosity values were found different ( p
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- 2006
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7. Genetically Stable Picornavirus Expression Vectors with Recombinant Internal Ribosomal Entry Sites
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Elena Y. Dobrikova, Andrew T. Dufresne, Stacie Schmidt, and Matthias Gromeier
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Rhinovirus ,Picornavirus ,Genetic Vectors ,Molecular Sequence Data ,Immunology ,Heterologous ,Picornaviridae ,Microbiology ,Insert (molecular biology) ,law.invention ,Viral Matrix Proteins ,Drug Stability ,law ,Virology ,Vaccines and Antiviral Agents ,Animals ,Humans ,Vector (molecular biology) ,Gene ,Recombination, Genetic ,Genetics ,Expression vector ,Base Sequence ,biology ,biology.organism_classification ,Regulatory sequence ,Drug Design ,Insect Science ,Recombinant DNA ,Simian Immunodeficiency Virus ,Ribosomes ,Gene Deletion ,HeLa Cells - Abstract
In many respects, picornaviruses are well suited for their proposed use as immunization vectors. However, their inherent genetic instability hinders application for prophylactic purposes. We demonstrate the improved expression and stability of a heterologous insert through a novel vector design strategy that partially replaces noncoding regulatory sequences with coding sequences for foreign gene products.
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- 2002
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8. Phosphate Ester-based Fluid Specific Resistance: Effects of Outside Contamination and Improvement Using Novel Media
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Hobbs Matthew and Peter T. Dufresne
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chemistry.chemical_compound ,Materials science ,chemistry ,Environmental chemistry ,Contamination ,Phosphate ,Specific resistance - Published
- 2014
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9. Thirty-Seven Years of Fleet Operating and Maintenance Experience Using Phosphate Ester Fluids for Bearing Lubrication in Gas-Turbine/Turbo-Compressor Applications
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Peter T. Dufresne
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Gas turbines ,Bearing (mechanical) ,Materials science ,Petroleum engineering ,biology ,law ,Turbo ,Metallurgy ,Lubrication ,Economic analysis ,biology.organism_classification ,Gas compressor ,law.invention - Published
- 2014
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10. A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice
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Matthias Gromeier and Andrew T. Dufresne
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Genetically modified mouse ,viruses ,Intercellular Adhesion Molecule-1 ,Coxsackievirus A21 ,Gene Expression ,Mice, Transgenic ,Biology ,medicine.disease_cause ,Axonal Transport ,Virus ,Mice ,medicine ,Animals ,Humans ,Receptor ,Muscle, Skeletal ,Tropism ,Enterovirus ,Motor Neurons ,Multidisciplinary ,Poliovirus ,virus diseases ,Biological Sciences ,Virology ,Immunohistochemistry ,Spinal Cord ,Organ Specificity ,Poliomyelitis - Abstract
Coxsackievirus A21 (CAV21) is classified within the species Human enterovirus C (HEV-C) of the Enterovirus genus of picornaviruses. HEV-C share striking homology with the polioviruses (PV), their closest kin among the enteroviruses. Despite a high level of sequence identity, CAV21 and PV cause distinct clinical disease typically attributed to their differential use of host receptors. PV cause poliomyelitis, whereas CAV21 shares a receptor and a propensity to cause upper respiratory tract infections with the major group rhinoviruses. As a model for CAV21 infection, we have developed transgenic mice that express human intercellular adhesion molecule 1, the cell-surface receptor for CAV21. Surprisingly, CAV21 administered to these mice via the intramuscular route causes a paralytic condition consistent with poliomyelitis. The virus appears to invade the CNS by retrograde axonal transport, as has been demonstrated to occur in analogous PV infections. We detected human intercellular adhesion molecule 1 expression on both transgenic mouse and human spinal cord anterior horn motor neurons, indicating that members of HEV-C may share PV's potential to elicit poliomyelitis in humans.
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- 2004
11. Jones on ice: psychoanalysis and figure skating
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T, Dufresne and G, Genosko
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Skating ,Humans ,Psychoanalysis ,Psychoanalytic Interpretation ,Psychoanalytic Therapy - Abstract
This paper rescues Ernest Jones's largely-unknown book, 'The Elements of Figure Skating' (1931/1952), from relative obscurity and argues for its place in the psychoanalytic literature. In the first section, the authors situate Jones's passion for figure skating by turning to various historical and biographical sources, and to personal correspondence with Jones's son, Mervyn Jones. In the second section, they offer the first textual reading of Jones and skating within a psychoanalytic framework. This approach, they argue, is long overdue since Jones explicitly claimed that the 'Elements' was motivated by his interest in the 'psychological' problems of the beginning skater, and with the task of instruction therein. The authors rely heavily on passages from the 'Elements', in part because the book is out-of-print and unavailable to most readers, but also because Jones's own words are an exemplary instance of his intense transference to psychoanalytic theory during his extra-professional time as a skater. They conclude the paper by arguing that Jones ultimately advocates a position beyond psychology when he idealistically embraces 'exact knowledge' as the royal road to masterful skating.
- Published
- 1995
12. Phase I study of the effects of hepatic impairment on the pharmacokinetic (PK) and safety of satraplatin in patients with refractory non-hematologic cancer
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C. Takemoto, G. Preston, R. F. Setlik, F. E. Nathan, T. Anthony, Michael E. Petrone, C. B. Jones, John Sarantopoulos, T. Dufresne, and D. Greene
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Oncology ,Cancer Research ,medicine.medical_specialty ,Hematologic cancer ,business.industry ,Hepatic impairment ,Satraplatin ,Pharmacology ,Phase i study ,chemistry.chemical_compound ,Refractory ,Pharmacokinetics ,chemistry ,Internal medicine ,Medicine ,In patient ,business - Abstract
2045 Background: Satraplatin (S) is a third-generation oral platinum analog that has demonstrated activity in the treatment of patients with platinum-sensitive malignancies. A worldwide double-blind, placebo controlled randomized phase III trial evaluating S as 2nd line therapy for HRPC has recently completed enrollment. The current study was designed to determine the effect of hepatic impairment on S pharmacokinetics in patients with refractory cancer, as well as treatment efficacy and toxicity. Methods: S was administered orally at a dose of 80mg/m2/day (d) on d1–5 every 35 days. Study groups (cohorts) were defined at 4 levels of hepatic impairment - Group 1 (G1) = control; G2 = Child-Pugh Class A; G3 = Child-Pugh Class B; and Group 4 = Child-Pugh Class C. Results: 19 pts have been enrolled to date (11 M/ 8 F); median age is 57 (range 44–80). Pts with prostate (2), pancreas (4), colorectal (3), adenocystic (2), and 1 each neuroendocrine, hepatocellular, melanoma, breast, ovarian, SCLC, and anal cancers were enrolled. 8 pts were in G1, 3 pts in G2, 4 pts in G3, and 5 pts in G4. Accrual is ongoing in this study with a total of 8 pts planned for each group. The median number of prior regimens was 5 (range 2–8). A total of 35 cycles of S have been given: median 2/pt (range 1–4). 9 pts have completed 2 cycles of S. Hematologic toxicities during the first 2 cycles included grade (G) 3/4 thrombocytopenia in 15 %. There were no cases of G 3/4 neutropenia or anemia. One case of G3 hypokalemia, was reported. Two patients developed acute renal failure; one of which was due to uncontrolled nausea (N) and vomiting (V) and the other was associated with rapid disease progression in the liver. Both were G4 patients. Otherwise, N, V, and diarrhea were mild to moderate, and controlled with oral therapy. Conclusions: S is, in general, well tolerated in patients with mild or moderate liver impairment. Severe thrombocytopenia is the most common side-effect. Of the patients enrolled to date 15% did not have progression of disease. PK data will also be presented. [Table: see text]
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- 2006
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13. A phase I and pharmacokinetic study of nolatrexed dihydrochloride, a potent thymidylate synthase (TS) inhibitor, combined with docetaxel in patients with advanced cancer
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T. Dufresne, Emiliano Calvo, A. Ricart, J. Cooper, Chris H. Takimoto, G. Suplick, J. Garcia-Vargas, Kyriakos P. Papadopoulos, E. K. Rowinsky, and Samira Syed
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Cancer Research ,Lung ,biology ,business.industry ,Head and neck tumors ,Pharmacology ,Advanced cancer ,Thymidylate synthase ,digestive system diseases ,medicine.anatomical_structure ,Oncology ,Docetaxel ,Pharmacokinetics ,medicine ,Nolatrexed dihydrochloride ,biology.protein ,In patient ,business ,medicine.drug - Abstract
2115 Background: Thymitaq (Th) is a potent and direct inhibitor of TS which has shown activity in patients with head and neck tumors or hepatocarcinoma, as well as in breast, ovarian, and lung canc...
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- 2005
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14. Stereological simulator for analysis of sensitivity to localized bone changes
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T DUFRESNE
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Histology ,Physiology ,Endocrinology, Diabetes and Metabolism - Published
- 1996
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15. Predictive outcome factors in the treatment of subarachnoid hemorrhage with hematoma caused by ruptured anterior circulation aneurysms: A monocentric experience.
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Devalckeneer A, Haettel P, Poidevin P, Bretzner M, Dufresne T, Poulain A, Menovsky T, Delhem N, and Aboukaïs R
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Introduction: Intracranial aneurysm (IA) rupture accounts for 3% of strokes and is associated with a concerning mortality rate. Subarachnoid hemorrhage with cerebral hematoma (CSAH) often results in a higher mortality rate; however, the optimal treatment approach remains unclear. This study aims to identify factors predicting poor outcomes and mortality in cases of CSAH due to ruptured aneurysms in the anterior cerebral circulation., Methods: This study retrospectively included 102 patients with anterior circulation aneurysm ruptures, treated between 2017 and 2019. A multidisciplinary team determined the treatment strategies. Statistical analyses were performed to assess outcomes., Results: In the bivariate analysis of CSAH related to anterior circulation aneurysm rupture, significant factors associated with morbidity (mRS >2 at one year follow-up) and mortality were: WFNS score severity, mydriasis, Tako-Tsubo, and the presence of hydrocephalus. In the multivariate analysis, significant factors for mortality were hydrocephalus (p < 0.01) and Tako-Tsubo (p < 0.001), while significant factors for morbidity were hydrocephalus (p < 0.01) and hematoma volume (p = 0.012)., Conclusion: Our study analyzed a series of cases involving CSAH from anterior circulation aneurysms. We emphasize the importance of prompt treatment for hydrocephalus and suggest that the diagnosis of Tako-Tsubo should delay but not prevent treatment. Depending on local ethical standards, treatment abstention could be considered in patients with severe WFNS scores, the presence of mydriasis, hematoma >45 mL, and hydrocephalus. Our findings indicate that life-threatening hematomas are best managed surgically, while smaller, non-life-threatening cases may benefit from endovascular treatment, though further randomized trials are needed for validation., Competing Interests: Declaration of competing interest Informed consent was obtained from all individual participants included in the study., (Copyright © 2025 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
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- 2025
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16. Comparison of two methods to categorize thickened liquids for dysphagia management in a clinical care setting context: The Bostwick consistometer and the IDDSI Flow Test. Are we talking about the same concept?
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Côté C, Germain I, Dufresne T, and Gagnon C
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- Deglutition, Food, Humans, Physical Phenomena, Reproducibility of Results, Rheology, Viscosity, Beverages, Deglutition Disorders diet therapy, Diet
- Abstract
The Bostwick consistometer and the International Dysphagia Diet Standardization Initiative (IDDSI) Flow Test are both proposed methods to measure and categorize thickened liquids for dysphagia management. The objectives were to: (a) compare the Bostwick consistometer reference values used in clinical settings and the IDDSI reference values of thickened liquids suggested for nutrition care plans in the management of dysphagia when measuring commercially available preprepared thickened liquids; (b) explore the relationship between the two methods; (c) assess the interchangeability; (d) document the intra-rater reliability. Preprepared thickened liquids (n = 32) were measured twice with the Bostwick consistometer and 3 times with the IDDSI Flow Test, using a rigorous methodology. A registered dietitian nutritionist and a registered nutrition and dietetic technician performed the measurements. The Pearson's correlation coefficient was calculated to explore the relationship between the two methods. Using a linear regression equation, back-calculations of the IDDSI Flow Test values were done, based on the experimental Bostwick results. Interchangeability was assessed by documenting the level of agreement between the results with a Bland and Altman graphical analysis. Intraclass correlation coefficients calculation and a Bland and Altman graphical analysis were performed to assess reliability. The strong correlation (r = -.93, p < .001) between the IDDSI Flow Test and the Bostwick consistometer measurements suggests that they measure flow rate in a similar manner, but not exactly the same, as confirmed with the Bland and Altman graphical analysis. Thus, they produced results that are not interchangeable. However, both tests show excellent intra-rater reliability (ICC ≥ 0.99) when using a rigorous methodology. PRACTICAL APPLICATIONS: Thickened liquids are used to manage oropharyngeal dysphagia. Clinicians need to provide quality assurance/quality control (QA/QC) support in the selection or production of thickened liquids as well as staff training or patient education regarding these products. Methods and classification have been proposed to measure and categorize thickened liquids for dysphagia management, such as the line spread test, the Bostwick consistometer method, and the IDDSI Flow Test. Although empirical, these methods are more accessible to clinicians than viscometer or rheometer assessments. Clinicians need to understand the limitations of these techniques as neither appear to capture the full extent of consistency for potential beverages available on the market or produced in-house. In this article, we compare the Bostwick consistometer and the IDDSI Flow Test methods and classifications and propose a standard operating procedure in order to maximize the quality of results. We point out the large variations in consistency levels of commercial preprepared thickened liquids in light of the absence of evidence of clinical outcomes associated with either proposed methods or consistency classifications., (© 2018 Wiley Periodicals, Inc.)
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- 2019
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17. Risedronate reduces intracortical porosity in women with osteoporosis.
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Borah B, Dufresne T, Nurre J, Phipps R, Chmielewski P, Wagner L, Lundy M, Bouxsein M, Zebaze R, and Seeman E
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- Aged, Bone Density drug effects, Demography, Etidronic Acid pharmacology, Etidronic Acid therapeutic use, Female, Humans, Periosteum drug effects, Periosteum pathology, Porosity drug effects, Risedronic Acid, X-Ray Microtomography, Bone Density Conservation Agents pharmacology, Bone Density Conservation Agents therapeutic use, Bone and Bones drug effects, Bone and Bones pathology, Etidronic Acid analogs & derivatives, Osteoporosis, Postmenopausal drug therapy
- Abstract
Nonvertebral fractures account for 80% of all fractures and their accompanying morbidity and mortality. Despite this, the effect of drug therapy on cortical morphology has received limited attention, partly because cortical bone is believed to remodel less and decrease less with age than trabecular bone. However, the haversian canals traversing the cortex provide a surface for remodeling that produces bone loss, porosity, and cortical fragility. We developed a new method of 3D micro-computed tomography (microCT) to quantify intracortical porosity and the effects of treatment. Women with osteoporosis randomized to risedronate (5 mg/day, n = 28) or placebo (n = 21) had paired transiliac biopsies at baseline and 5 years imaged using 3D microCT. Pores determined from 8 to 12 slices were stratified by their minor axis length into those 25 to 100 microm (closing cone of haversian canals), 100 to 300 microm (cutting cone of haversian canals), and >300 microm (coalescent cavities). Porosity was analyzed as pore area (percent bone area) and pore density (pore number/mm(2)). Medians are reported. Risedronate reduced pore area in the 25 to 100, 100 to 300, and 300 to 500 microm ranges over 5 years (p = .0008, .04, NS, respectively) corresponding to an 18% to 25% reduction. In the placebo group, pore area was unchanged. At 5 years, pore area and pore number/mm(2) in the 25 to 100 microm range were each 17% lower in the risedronate group than in the placebo group (p = .02 and .04, respectively). Risedronate is likely to maintain bone strength and reduce nonvertebral fracture risk in part by reducing remodeling and therefore the number and size of intracortical cavities., (2010 American Society for Bone and Mineral Research)
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- 2010
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18. Psychoanalysis eats its own: or, the heretical Saint Roazen.
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Dufresne T
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- Historiography, History, 20th Century, Psychoanalytic Theory, Psychoanalytic Therapy education, Authorship, Professional Role history, Professional Role psychology, Psychoanalysis education, Psychoanalysis history, Publications history, Research Personnel education, Research Personnel history, Research Personnel psychology
- Abstract
The author attempts a "Roazenesque" interpretation of Paul Roazen's life and work, and situates his career vis-á-vis that of other revisionist critics of Freud. To these ends, the essay charts the highs and lows of Roazen's long career as a biographer-historian of psychoanalysis. His career is divided into four phases, the first of which is arguably the most important. It was also the most controversial, producing classic books on Victor Tausk and on Freud's followers. Roazen's later work fares less well, even undermining his standing among scholars. If there is a commonality to the work of all four phases, it is Roazen's fairly constant recourse to interviews he conducted in the mid-1960s with many people intimate with Freud. On the good side, these interviews provided him unique access to details about Freud's everyday life and practice. Roazen thus became known as the historian of arcane detail. On the bad side, Roazen came to rely too heavily on these interviews and on his own singular role as interviewer. As a result his work became increasingly self-regarding and nostalgic, and thus less original, interesting, or discerning. His legacy is therefore mixed, although secure enough that future scholars will not easily ignore his contribution in a handful of good books.
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- 2007
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19. Multiple literacies: Linking the research on bilingualism and biliteracies to the practical.
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Dufresne T and Masny D
- Abstract
The present article addresses the fundamental developmental differences between monolingualism and bilingualism, as outlined in the literature. It takes into account research using qualitative and quantitative methodologies and reviews the advantages and possible disadvantages of bilingualism in preschool children. It then moves on to biliteracies in early childhood education. The questions addressed are: Will the early learning of a second language delay a child's language development? What effect does bilingualism have on the development of phonemic awareness, and does that have an impact on reading development? Do bilingual children have an advantage over monolingual children? What happens when a child with language impairment is called upon to develop two languages? What are some challenges regarding the acquisition of biliteracies? The present article concludes with recommendations for physicians who counsel bilingual families regarding early childhood literacy promotion and development.
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- 2006
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20. A novel dysphagia diet improves the nutrient intake of institutionalized elders.
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Germain I, Dufresne T, and Gray-Donald K
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- Aged, Aged, 80 and over, Body Mass Index, Dietary Carbohydrates administration & dosage, Dietary Fats administration & dosage, Dietary Fiber administration & dosage, Dietary Proteins administration & dosage, Female, Frail Elderly, Humans, Institutionalization, Male, Nutritional Requirements, Quebec, Treatment Outcome, Deglutition Disorders diet therapy, Energy Intake physiology, Foods, Specialized, Micronutrients administration & dosage, Weight Gain physiology
- Abstract
Objectives: Dysphagia affects 35% to 60% of the institutionalized elderly population. This study aimed at evaluating the nutrient intake of frail institutionalized elderly persons with dysphagia and to assess the impact of Sainte-Anne's Hospital Advanced Nutritional Care program on dietary intake and weight., Design: A 12-week intervention study., Subjects/setting: Ninety-three individuals residing in a Montreal, Canada, long-term care facility who were aged at least 65 years were evaluated. Seventeen subjects with a body mass index (BMI; calculated as kg/m(2)) <24 or weight loss >7.5% within 3 months and with dysphagia were included., Intervention: The treated group (n=8; aged 82.5+/-4.41 years, weight 55.9+/-12.1 kg, BMI 22.4+/-3.93) received Sainte-Anne's Hospital reshaped minced- or pureed-texture foods with thickened beverages where required. The control group (n=9; aged 84.6+/-3.81 years, weight 54.3+/-7.49 kg, BMI 21.2+/-2.31) maintained traditional nourishment., Main Outcome Measures: Macronutrient and micronutrient intake, weight, and BMI were measured at baseline, 6 weeks, and 12 weeks., Statistics: Student t tests were performed to evaluate change within and between groups., Results: The treatment and control groups were similar at baseline, having a mean age of 82.5+/-4.41 years vs 84.6+/-3.81 years and BMI of 22.4+/-3.93 vs 21.2+/-2.31, respectively. The average weight in the treated group increased compared to the control group (3.90+/-2.30 vs -0.79+/-4.18 kg; P=0.02). Similarly, the treated group presented an increased intake of energy, proteins, fats, total saturated fats, monounsaturated fats, potassium, magnesium, calcium, phosphorus, zinc, vitamin B-2, and vitamin D compared to control subjects (P<0.05)., Conclusion: Institutionalized elderly patients with dysphagia can eat better and increase body weight via a diversified, modified in texture, and appealing oral diet that meets their nutrition needs.
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- 2006
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21. Segmentation techniques for analysis of bone by three-dimensional computed tomographic imaging.
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Dufresne T
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- Algorithms, Animals, Bone and Bones pathology, Humans, Ilium pathology, Rats, Spine diagnostic imaging, Bone and Bones diagnostic imaging, Image Processing, Computer-Assisted methods, Tomography, X-Ray Computed methods
- Abstract
Improved methods for evaluation and quantification of the three-dimensional (3D) architecture of bone are needed in order to more fully understand the role of trabecular architecture in bone strength. Computed tomography (microCT) is capable of examining bone at resolutions below 30 microm (isotropic), with collection of a three-dimensional data set which can then be subjected to image analysis. In this paper, we discuss automated methods for important steps in this analysis, including methods for (1) segmenting the image into bone and background; (2) defining the volume of interest for determination of structural parameters; and (3) segmenting the bone into trabecular and cortical components. Evaluation of bone structure using these techniques provides new information about the 3D architecture of bone tissue, and may be useful for evaluation of structural changes in bone caused by aging, disease, or drug treatment.
- Published
- 1998
22. Jones on ice: psychoanalysis and figure skating.
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Dufresne T and Genosko G
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- Humans, Psychoanalysis, Psychoanalytic Interpretation, Psychoanalytic Therapy, Skating
- Abstract
This paper rescues Ernest Jones's largely-unknown book, 'The Elements of Figure Skating' (1931/1952), from relative obscurity and argues for its place in the psychoanalytic literature. In the first section, the authors situate Jones's passion for figure skating by turning to various historical and biographical sources, and to personal correspondence with Jones's son, Mervyn Jones. In the second section, they offer the first textual reading of Jones and skating within a psychoanalytic framework. This approach, they argue, is long overdue since Jones explicitly claimed that the 'Elements' was motivated by his interest in the 'psychological' problems of the beginning skater, and with the task of instruction therein. The authors rely heavily on passages from the 'Elements', in part because the book is out-of-print and unavailable to most readers, but also because Jones's own words are an exemplary instance of his intense transference to psychoanalytic theory during his extra-professional time as a skater. They conclude the paper by arguing that Jones ultimately advocates a position beyond psychology when he idealistically embraces 'exact knowledge' as the royal road to masterful skating.
- Published
- 1995
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