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1. Ultra-violet imaging of the night-time earth by EUSO-Balloon towards space-based ultra-high energy cosmic ray observations

Author: A. Anzalone, Toshiyuki Nonaka, Javier Licandro, K. Benmessai, B. Beldjilali, E. Kuznetsov, N. Blanc, J. L. Marcos, G. Puehlhofer, T. Djemil, Toshiki Tajima, Giuseppe Giraudo, A. Kedadra, K. S. Caballero, M. Di Martino, M. Ave Pernas, S. Blin-Bondil, G. Cordero, H. Khales, L. Allen, P. Baragatti, A. Marini, Hitoshi Ohmori, Alberto Cellino, Hiroyuki Sagawa, I. Dutan, Yoshiya Kawasaki, T. Napolitano, malek mastafa, B. A. Khrenov, Sebastián Franchini, T. Paul, G. Cotto, C. De Donato, I. Stan, P. Gorodetzky, A. Pagliaro, S. Jeong, J. Watanabe, Piergiorgio Picozza, D. Allard, M. Suzuki, L. López Campano, Soon-Wook Kim, J. Rabanal, G. Osteria, Guillaume Prévôt, O. Larsson, L. R. Wiencke, A. Ebersoldt, Yoshio Arai, Francesca Bisconti, J. Hernández Carretero, Katsuhiko Tsuno, I. Kreykenbohm, D. Kolev, A. Radu, N. Tajima, M. Takeda, Shigehiro Nagataki, A. Guzmán, C. Lachaud, Christer Fuglesang, José Meseguer, A. Menshikov, Osvaldo Catalano, Silvia Ferrarese, R. Greg, J. Mimouni, C. González Alvarado, M. E. Bertaina, Valentina Scotti, M. Bogomilov, N. Mebarki, Y. Martín, C. De Santis, Ken'ichi Nomoto, G. Chiritoi, R. Attallah, N. Tone, K. Martens, Valerie Connaughton, Angel Sanz-Andrés, L. Marcelli, G. Masciantonio, I. S. Zgura, J. Tubbs, Hirohiko M. Shimizu, Austin Cummings, M. Wille, H. Krantz, F. Kajino, A. Jung, Y. Tsunesada, Y. Uchihori, A. La Barbera, H. Lahmar, Daisuke Yonetoku, G. Medina-Tanco, Mohammed Bakiri, Maciej Rybczyński, K. Kudela, J. F. Krizmanic, J. Genci, Konstantin Belov, F.J. Ronga, Yoshimasa Kurihara, C. Moretto, A. Diaz Damian, Jin Yong Lee, H. Schieler, Alfonso Monaco, Antonella Castellina, Mitsuteru Sato, N. Inoue, L. del Peral, A. Franceschi, E. Parizot, Z. Polonsky, Humberto Ibarguen Salazar, T. Shirahama, T. Jammer, Santiago Pindado, Junpei Fujimoto, G. Abdellaoui, L. Villaseñor, Y. Hachisu, G. Roudil, H. Tokuno, Pavol Bobik, F. Perfetto, Hajime Yano, O. Martinez, Bruno Spataro, Tokonatsu Yamamoto, S. Kalli, M. Yu. Zotov, John N. Matthews, Katsuaki Asano, Estíbaliz Gascón, B. Harlov, Carlo Vigorito, Roberto Bellotti, K. Mase, R. Nava, B. Pastirčák, J. Watts, E. Bozzo, S. Turriziani, Toshikazu Ebisuzaki, M. A. Mendoza, Pierre Barrillon, S. Briz, Eduardo García-Ortega, M. Sanz Palomino, E. M. Popescu, Barbara Szabelska, W. Painter, James H. Adams, Sergei A. Sharakin, Rossella Caruso, M. Vrabel, P. Prat, Francesco Isgrò, S. Bartocci, M. Traïche, Josef Jochum, Piero Vallania, M. D. Sabau, Z. Sahnoune, J. A. Morales de los Ríos, T. Peter, S. Naitamor, R. Tsenov, Tomás Belenguer, J. C. Sanchez Balanzar, Gustavo Alonso, F. Cafagna, W. Marszał, Satoshi Wada, Toshitaka Kajino, Piotr Orleanski, J.N. Capdevielle, R. Young, D. Campana, F. Lakhdari, T. Ogawa, W. Hidber Cruz, Thomas Schanz, Daisuke Ikeda, E. Joven, Inkyu Park, N. Belkhalfa, Francesca Capel, P. Galeotti, A. Pollini, Pavel Klimov, B. Panico, M. C. Talai, S. Bacholle, A. J. de Castro, M. Putis, M. Haiduc, Lech Wiktor Piotrowski, Susumu Inoue, S. S. Meyer, Francesco Fenu, S. B. Thomas, H. Miyamoto, Livio Conti, Angela V. Olinto, H. Attoui, Ovidiu Vaduvescu, C. Tenzer, T. Sugiyama, J. Błȩcki, Sergio Fernández-González, R. Matev, J. F. Valdés-Galicia, J. Bayer, Claudio Cassardo, Andrea Santangelo, A. Neronov, L. G. Tkachev, Simona Toscano, A. Weindl, A. Zuccaro Marchi, M. C. Maccarone, M. Fouka, S. Mackovjak, S. Yoshida, J. Szabelski, L. Caramete, Jörn Wilms, Takayuki Tomida, Dmitri Semikoz, C. de la Taille, Naoto Sakaki, C. Catalano, G. Vankova, D. Supanitsky, Mark Christl, O. Tibolla, O. A. Saprykin, Yoshitaka Itow, K. Katahira, A. Belov, H. Prieto, A. Caramete, R. Cremonini, Andrés Merino, Hajime Takami, F. López, M. Rezazadeh, S. Selmane, D. Maravilla, S. Biktemerova, Masaki Fukushima, E. G. Judd, Isabel Pérez-Grande, Shinsuke Abe, P. Carlson, F. Sarazin, A. Haungs, S. Piraino, Kenji Shinozaki, Zbigniew Wlodarczyk, H. J. Crawford, Gali Garipov, Marc Weber, R. Weigand Muñoz, A. Kusenko, S. Pliego, M. Martucci, Shoichi Ogio, Y. Karadzhov, M. Flamini, J. Yang, B. Vlcek, Y. Takizawa, Amine Ahriche, L. Placidi, P. L. Biermann, M. D. Rodríguez Frías, M. Kleifges, I. Rusinov, Z. Plebaniak, I. V. Yashin, K. Kawai, Michiyuki Chikawa, Marcos Reyes, Akinori Saito, S. E. Csorna, Johannes Eser, M. Serra, Luis A. Anchordoqui, A. Bruno, Jeong-Sook Kim, I. Kaneko, T. Patzak, Yoshihiko Mizumoto, J. Karczmarczyk, G. Sáez Cano, Fausto Guarino, P. von Ballmoos, M. Ricci, S. Dagoret-Campagne, Yukihiro Takahashi, José Luis Sánchez, Marco Casolino, Claudio Fornaro, Mikhail Panasyuk, Ralph Engel, Takahiro Fujii, M. Mahdi, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Organisation de Micro-Électronique Générale Avancée (OMEGA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Abdellaoui, G., Abe, S., Adams, J. H., Ahriche, A., Allard, D., Allen, L., Alonso, G., Anchordoqui, L., Anzalone, A., Arai, Y., Asano, K., Attallah, R., Attoui, H., Ave Pernas, M., Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A., Belov, K., Benmessai, K., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Blecki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bozzo, E., Briz, S., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J. -N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, C., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cordero, G., Cotto, G., Crawford, H. J., Cremonini, R., Csorna, S., Cummings, A., Dagoret-Campagne, S., de Castro, A. J., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Diaz Damian, A., Djemil, T., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fenu, F., Fernandez-Gonzalez, S., Ferrarese, S., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fujimoto, J., Fukushima, M., Galeotti, P., Garcia-Ortega, E., Garipov, G., Gascon, E., Genci, J., Giraudo, G., Gonzalez Alvarado, C., Gorodetzky, P., Greg, R., Guarino, F., Guzman, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Hernandez Carretero, J., Hidber Cruz, W., Ikeda, D., Inoue, N., Inoue, S., Isgro, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, J. -S., Kim, S. -W., Kleifges, M., Klimov, P. A., Kolev, D., Krantz, H., Kreykenbohm, I., Krizmanic, J. F., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., La Barbera, A., Lachaud, C., Lahmar, H., Lakhdari, F., Larsson, O., Lee, J., Licandro, J., Lopez Campano, L., Lopez, F., Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Marszal, W., Martens, K., Martin, Y., Martinez, O., Martucci, M., Masciantonio, G., Mase, K., Mastafa, M., Matev, R., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Mendoza, M. A., Menshikov, A., Merino, A., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Morales de los Rios, J. A., Moretto, C., Nagataki, S., Naitamor, S., Napolitano, T., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleanski, P., Osteria, G., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, Beatrice, Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Perez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Polonsky, Z., Popescu, E. M., Prat, P., Prevot, G., Prieto, H., Puehlhofer, G., Putis, M., Rabanal, J., Radu, A. A., Reyes, M., Rezazadeh, M., Ricci, M., Rodriguez Frias, M. D., Ronga, F., Roudil, G., Rusinov, I., Rybczynski, M., Sabau, M. D., Saez Cano, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sanchez Balanzar, J. C., Sanchez, J. L., Santangelo, A., Sanz-Andres, A., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, M., Schanz, T., Schieler, H., Scotti, V., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shimizu, H. M., Shinozaki, K., Shirahama, T., Spataro, B., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traiche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tubbs, J., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdes-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villasenor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts, J., Weber, M., Weigand Munoz, R., Weindl, A., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Y., Zuccaro Marchi, A., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)
Subjects: lens, air, media_common.quotation_subject, tube, JEM-EUSO, Extensive air shower, Airglow, EUSO-Balloon, Ultra-high energy cosmic ray, 7. Clean energy, 01 natural sciences, detector: fluorescence, Aeronáutica, pixel, 0103 physical sciences, ultraviolet, Ultra-high-energy cosmic ray, cosmic radiation: UHE, backscatter, 010303 astronomy & astrophysics, particle source, Astrophysique, media_common, Physics, COSMIC cancer database, showers: atmosphere, Settore FIS/05, 010308 nuclear & particles physics, background, photon, Astronomy, imaging, Astronomy and Astrophysics, Astronomie, Photon counting, Universe, observatory, Pathfinder, Refracting telescope, trajectory, Trajectory, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], satellite: orbit
Abstract: The JEM-EUSO (Joint Experiment Missions for the Extreme Universe Space Observatory) program aims at developing Ultra-Violet (UV) fluorescence telescopes for efficient detections of Extensive Air Showers (EASs) induced by Ultra-High Energy Cosmic Rays (UHECRs) from satellite orbit. In order to demonstrate key technologies for JEM-EUSO, we constructed the EUSO-Balloon instrument that consists of a ∼1 m 2 refractive telescope with two Fresnel lenses and an array of multi-anode photo-multiplier tubes at the focus. Distinguishing it from the former balloon-borne experiments, EUSO-Balloon has the capabilities of single photon counting with a gate time of 2.3 µs and of imaging with a total of 2304 pixels. As a pathfinder mission, the instrument was launched for an 8 h stratospheric flight on a moonless night in August 2014 over Timmins, Canada. In this work, we analyze the count rates over ∼2.5 h intervals. The measurements are of diffuse light, e.g. of airglow emission, back-scattered from the Earth's atmosphere as well as artificial light sources. Count rates from such diffuse light are a background for EAS detections in future missions and relevant factor for the analysis of EAS events. We also obtain the geographical distribution of the count rates over a ∼780 km 2 area along the balloon trajectory. In developed areas, light sources such as the airport, mines, and factories are clearly identified. This demonstrates the correct location of signals that will be required for the EAS analysis in future missions. Although a precise determination of count rates is relevant for the existing instruments, the absolute intensity of diffuse light is deduced for the limited conditions by assuming spectra models and considering simulations of the instrument response. Based on the study of diffuse light by EUSO-Balloon, we also discuss the implications for coming pathfinders and future space-based UHECR observation missions., 0, SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2019
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2. Détermination de la composition de 359 calculs du haut appareil urinaire collectés dans la région Est-algérien

Author: Michel Daudon, T. Djemil, A. Dahdouh, A. Boutefnouchet, S. Bouslama, S. Saka, A. Kadi, and B. Hannache
Subjects: 0301 basic medicine, Gynecology, 03 medical and health sciences, medicine.medical_specialty, 030104 developmental biology, 0302 clinical medicine, business.industry, Urology, 030232 urology & nephrology, Medicine, business
Abstract: Resume But Determiner la composition des calculs du haut appareil urinaire dans la region Est-algerien. Methodes L’etude porte sur 359 calculs renaux ou ureteraux collectes entre janvier 2007 et decembre 2012 dans les centres hospitaliers de l’Est-algerien et analyses par spectrophotometrie infrarouge a transformee de Fourier. Resultats Le ratio hommes/femmes etait de 1,32. La composition des calculs montre que l’oxalate de calcium etait majoritaire dans 68,5 % des calculs et 49,3 % des noyaux, la whewellite etant predominante (51,8 % des calculs et 37,9 % des noyaux versus 16,7 % et 11,4 % respectivement pour la weddellite). La carbapatite etait majoritaire dans 15 % des calculs et 29,8 % des noyaux. La struvite, detectee dans 11,1 % des calculs, etait majoritaire dans 3,9 % des calculs et 3,1 % des noyaux. Parmi les purines, l’acide urique etait majoritaire dans 8,9 % des calculs et 7 % des noyaux et l’urate d’ammonium dans 0,3 % des calculs et 3,3 % des noyaux. Enfin, la cystine composait 3,6 % des calculs et des noyaux. La frequence des calculs ombiliques etait de 26,2 %, la whewellite etant le composant principal des calculs inities sur plaque de Randall. Conclusion Nos resultats montrent que la lithiase de l’arbre urinaire dans l’Est-algerien ressemble a celle des pays industrialises. Certaines caracteristiques telles que la localisation des calculs, la predominance de la whewellite, les frequences des constituants majoritaires dans les calculs et les noyaux ainsi que la proportion des calculs formes sur plaque de Randall viennent confirmer cette tendance. Niveau de preuve 4.
Published: 2016
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3. First observations of speed of light tracks by a fluorescence detector looking down on the atmosphere

Author: G. Abdellaoui, S. Abe, J.H. Adams Jr., A. Ahriche, D. Allard, L. Allen, G. Alonso, L. Anchordoqui, A. Anzalone, Y. Arai, K. Asano, R. Attallah, H. Attoui, M. Ave Pernas, S. Bacholle, M. Bakiri, P. Baragatti, P. Barrillon, S. Bartocci, J. Bayer, B. Beldjilali, T. Belenguer, N. Belkhalfa, R. Bellotti, A. Belov, K. Belov, K. Benmessai, M. Bertaina, P.L. Biermann, S. Biktemerova, F. Bisconti, N. Blanc, J. Błȩcki, S. Blin-Bondil, P. Bobik, M. Bogomilov, E. Bozzo, A. Bruno, K.S. Caballero, F. Cafagna, D. Campana, J-N. Capdevielle, F. Capel, A. Caramete, L. Caramete, P. Carlson, R. Caruso, M. Casolino, C. Cassardo, A. Castellina, C. Catalano, O. Catalano, A. Cellino, M. Chikawa, G. Chiritoi, M.J. Christl, V. Connaughton, L. Conti, G. Cordero, G. Cotto, H.J. Crawford, R. Cremonini, S. Csorna, A. Cummings, S. Dagoret-Campagne, C. De Donato, C. de la Taille, C. De Santis, L. del Peral, M. Di Martino, A. Diaz Damian, T. Djemil, I. Dutan, A. Ebersoldt, T. Ebisuzaki, R. Engel, J. Eser, F. Fenu, S. Fernández-González, J. Fernández-Soriano, S. Ferrarese, M. Flamini, C. Fornaro, M. Fouka, A. Franceschi, S. Franchini, C. Fuglesang, T. Fujii, J. Fujimoto, M. Fukushima, P. Galeotti, E. García-Ortega, G. Garipov, E. Gascón, J. Genci, G. Giraudo, C. González Alvarado, P. Gorodetzky, R. Greg, F. Guarino, A. Guzmán, Y. Hachisu, M. Haiduc, B. Harlov, A. Haungs, J. Hernández Carretero, W. Hidber Cruz, D. Ikeda, N. Inoue, S. Inoue, F. Isgrò, Y. Itow, T. Jammer, S. Jeong, E. Joven, E.G. Judd, A. Jung, J. Jochum, F. Kajino, T. Kajino, S. Kalli, I. Kaneko, Y. Karadzhov, J. Karczmarczyk, K. Katahira, K. Kawai, Y. Kawasaki, A. Kedadra, H. Khales, B.A. Khrenov, Jeong-Sook Kim, Soon-Wook Kim, M. Kleifges, P.A. Klimov, D. Kolev, H. Krantz, I. Kreykenbohm, K. Kudela, Y. Kurihara, A. Kusenko, E. Kuznetsov, A. La Barbera, C. Lachaud, H. Lahmar, F. Lakhdari, R. Larson, O. Larsson, J. Lee, J. Licandro, L. López Campano, M.C. Maccarone, S. Mackovjak, M. Mahdi, D. Maravilla, L. Marcelli, J.L. Marcos, A. Marini, W. Marszał, K. Martens, Y. Martín, O. Martinez, M. Martucci, G. Masciantonio, K. Mase, M. Mastafa, R. Matev, J.N. Matthews, N. Mebarki, G. Medina-Tanco, M.A. Mendoza, A. Menshikov, A. Merino, J. Meseguer, S.S. Meyer, J. Mimouni, H. Miyamoto, Y. Mizumoto, A. Monaco, J.A. Morales de los Ríos, C. Moretto, S. Nagataki, S. Naitamor, T. Napolitano, W. Naslund, R. Nava, A. Neronov, K. Nomoto, T. Nonaka, T. Ogawa, S. Ogio, H. Ohmori, A.V. Olinto, P. Orleański, G. Osteria, A. Pagliaro, W. Painter, M.I. Panasyuk, B. Panico, G. Pasqualino, E. Parizot, I.H. Park, B. Pastircak, T. Patzak, T. Paul, I. Pérez-Grande, F. Perfetto, T. Peter, P. Picozza, S. Pindado, L.W. Piotrowski, S. Piraino, L. Placidi, Z. Plebaniak, S. Pliego, A. Pollini, Z. Polonski, E.M. Popescu, P. Prat, G. Prévôt, H. Prieto, G. Puehlhofer, M. Putis, J. Rabanal, A.A. Radu, M. Reyes, M. Rezazadeh, M. Ricci, M.D. Rodríguez Frías, M. Rodencal, F. Ronga, G. Roudil, I. Rusinov, M. Rybczyński, M.D. Sabau, G. Sáez Cano, H. Sagawa, Z. Sahnoune, A. Saito, N. Sakaki, H. Salazar, J.C. Sanchez Balanzar, J.L. Sánchez, A. Santangelo, A. Sanz-Andrés, M. Sanz Palomino, O. Saprykin, F. Sarazin, M. Sato, T. Schanz, H. Schieler, V. Scotti, S. Selmane, D. Semikoz, M. Serra, S. Sharakin, H.M. Shimizu, K. Shinozaki, T. Shirahama, B. Spataro, I. Stan, T. Sugiyama, D. Supanitsky, M. Suzuki, B. Szabelska, J. Szabelski, N. Tajima, T. Tajima, Y. Takahashi, H. Takami, M. Takeda, Y. Takizawa, M.C. Talai, C. Tenzer, S.B. Thomas, O. Tibolla, L. Tkachev, H. Tokuno, T. Tomida, N. Tone, S. Toscano, M. Traïche, R. Tsenov, Y. Tsunesada, K. Tsuno, J. Tubbs, S. Turriziani, Y. Uchihori, O. Vaduvescu, J.F. Valdés-Galicia, P. Vallania, G. Vankova, C. Vigorito, L. Villaseñor, B. Vlcek, P. von Ballmoos, M. Vrabel, S. Wada, J. Watanabe, J. Watts Jr., M. Weber, R. Weigand Muñoz, A. Weindl, L. Wiencke, M. Wille, J. Wilms, Z. Włodarczyk, T. Yamamoto, J. Yang, H. Yano, I.V. Yashin, D. Yonetoku, S. Yoshida, R. Young, I.S Zgura, M.Yu. Zotov, A. Zuccaro Marchi, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Organisation de Micro-Électronique Générale Avancée (OMEGA), École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de recherche en astrophysique et planétologie (IRAP), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS), JEM-EUSO, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Abdellaoui, G., Abe, S., Adams, J., Ahriche, A., Allard, D., Allen, L., Alonso, G., Anchordoqui, L., Anzalone, A., Arai, Y., Asano, K., Attallah, R., Attoui, H., Ave Pernas, M., Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A., Belov, K., Belz, J. W., Benmessai, K., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Blecki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bozzo, E., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J-N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cordero, G., Cotto, G., Crawford, H. J., Cremonini, R., Csorna, S., Cummings, A., Dagoret-Campagne, S., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Djemil, T., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fenu, F., Fernández-González, S., Fernández-Soriano, J., Ferrarese, S., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fujimoto, J., Fukushima, M., Galeotti, P., García-Ortega, E., Garipov, G., Gascón, E., Genci, J., Giraudo, G., González Alvarado, C., Gorodetzky, P., Greg, R., Guarino, F., Guzmán, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Hernández Carretero, J., Hidber Cruz, W., Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kolev, D., Krantz, H., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., La Barbera, A., Lachaud, C., Lahmar, H., Lakhdari, F., Larsson, O., Lee, J., Licandro, J., López Campano, L., Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J., Marini, A., Marszal, W., Martens, K., Martín, Y., Martinez, O., Martucci, M., Masciantonio, G., Mase, K., Mustafa, M., Matev, R., Matthews, J., Mebarki, N., Medina-Tanco, G., Mendoza, M. A., Menshikov, A., Merino, A., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Morales de los Ríos, J. A., Nagataki, S., Naitamor, S., Napolitano, T., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleański, P., Osteria, G., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Polonski, Z., Popescu, E. M., Prat, P., Prévôt, G., Prieto, H., Puehlhofer, G., Putis, M., Rabanal, J., Radu, A. A., Reyes, M., Rezazadeh, M., Ricci, M., Rodríguez Frías, M. D., Ronga, F., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M., Sáez Cano, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sanchez Balanzar, J. C., Sánchez, J. L., Santangelo, A., Sanz-Andrés, A., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, M., Schanz, T., Schieler, H., Scotti, V., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shimizu, H. M., Shin, H. S., Shinozaki, K., Shirahama, T., Sokolsky, P., Spataro, B., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tameda, Y., Tenzer, C., Thomas, S. B., Thomson, G. B., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tubbs, J., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdés-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts, J., Weber, M., Weigand Muñoz, R., Weindl, A., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Yu., and Zuccaro Marchi, A.
Subjects: visible and IR photons, Balloon instrumentation, Detectors for UV, visible and IR photons, Lasers, Space instrumentation, Instrumentation, Mathematical Physics, Laser, chemistry.chemical_element, FOS: Physical sciences, 01 natural sciences, Fluorescence spectroscopy, law.invention, Aeronáutica, Atmosphere, Xenon, Optics, law, 0103 physical sciences, Calibration, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Detectors for UV, Physics, Instrumentation et méthodes en physique, 010308 nuclear & particles physics, business.industry, Detector, Autres mathématiques, Speed of light (cellular automaton), 3. Good health, Pathfinder, chemistry, business, Astrophysics - Instrumentation and Methods for Astrophysics, Detectors for UV, visible and IR photon
Abstract: EUSO-Balloon is a pathfinder mission for the Extreme Universe Space Observatory onboard the Japanese Experiment Module (JEM-EUSO). It was launched on the moonless night of the 25th of August 2014 from Timmins, Canada. The flight ended successfully after maintaining the target altitude of 38 km for five hours. One part of the mission was a 2.5 hour underflight using a helicopter equipped with three UV light sources (LED, xenon flasher and laser) to perform an inflight calibration and examine the detectors capability to measure tracks moving at the speed of light. We describe the helicopter laser system and details of the underflight as well as how the laser tracks were recorded and found in the data. These are the first recorded laser tracks measured from a fluorescence detector looking down on the atmosphere. Finally, we present a first reconstruction of the direction of the laser tracks relative to the detector., 0, SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2018
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4. EUSO-TA - First results from a ground-based EUSO telescope

Author: N. Inoue, L. del Peral, A. Franceschi, E. Parizot, Pavol Bobik, M. Haiduc, Lech Wiktor Piotrowski, S. Bartocci, J. A. Morales de los Ríos, N. Belkhalfa, Susumu Inoue, S. Yoshida, J. Szabelski, S. B. Thomas, K. Kudela, M. D. Rodríguez Frías, Naoto Sakaki, Z. Plebaniak, Thomas Schanz, Michiyuki Chikawa, M. Di Martino, A. Marini, Toshikazu Ebisuzaki, G. Roudil, B. Harlov, J. F. Valdés-Galicia, G. Osteria, Carlo Vigorito, L. G. Tkachev, Josef Jochum, S. Naitamor, G. Vankova, A. Caramete, Livio Conti, K. Martens, D. Maravilla, L. López Campano, J. Fernández-Soriano, R. Matev, Yoshihiko Mizumoto, Sebastián Franchini, S. Biktemerova, A. Ebersoldt, Daisuke Ikeda, A. Zuccaro Marchi, Hajime Takami, Masaki Fukushima, E. G. Judd, O. Larsson, H. J. Crawford, M. Serra, Jörn Wilms, J. Karczmarczyk, M. Ave Pernas, D. Kolev, H. Krantz, Mohammed Bakiri, Luis A. Anchordoqui, I. Kaneko, O. A. Saprykin, Estíbaliz Gascón, S. Turriziani, A. Belov, Valerie Connaughton, L. Marcelli, Konstantin Belov, A. Anzalone, T. Napolitano, Toshitaka Kajino, Francesco Fenu, N. Tone, Christer Fuglesang, Humberto Ibarguen Salazar, K. Benmessai, A. Guzmán, C. Lachaud, Daisuke Yonetoku, J. Blecki, José Meseguer, Angel Sanz-Andrés, Shinsuke Abe, P. Galeotti, R. Attallah, J. Hernández Carretero, H. Tokuno, B. Beldjilali, Takayuki Tomida, Santiago Pindado, S. Jeong, T. Shirahama, Y. Tsunesada, Junpei Fujimoto, M. Yu. Zotov, Silvia Ferrarese, Katsuaki Asano, Alfonso Monaco, H. Attoui, E. M. Popescu, B. A. Khrenov, A. Pagliaro, J. Genci, L. Villaseñor, C. Tenzer, T. Sugiyama, Piergiorgio Picozza, R. Tsenov, Satoshi Wada, N. Mebarki, W. Painter, Piotr Orleanski, T. Paul, A. Pollini, Pavel Klimov, B. Panico, Y. Karadzhov, Isabel Pérez-Grande, F. Sarazin, Zbigniew Wlodarczyk, Marc Weber, F. Bisconti, C. González Alvarado, Tokonatsu Yamamoto, E. Bozzo, T. Ogawa, M. C. Talai, J.N. Capdevielle, G. Sáez Cano, Angela V. Olinto, Javier Licandro, M. Rezazadeh, Andrea Santangelo, A. Kusenko, Katsuhiko Tsuno, Yoshio Arai, I. Kreykenbohm, Pierre Sokolsky, G. Masciantonio, Y. Martín, S. Selmane, John Belz, L. Placidi, M. Kleifges, P. L. Biermann, Tomás Belenguer, Yoshitaka Itow, N. Tajima, Giuseppe Giraudo, M. Takeda, M. A. Mendoza, G. Medina-Tanco, Shigehiro Nagataki, Barbara Szabelska, T. Peter, O. Martinez, Gordon Thomson, Toshiyuki Nonaka, F. Ronga, Gustavo Alonso, J. Watanabe, J. Tubbs, I. Rusinov, I. V. Yashin, M. Fouka, Osvaldo Catalano, M. Martucci, Fausto Guarino, J. Yang, P. von Ballmoos, M. Ricci, H. Miyamoto, M. Sanz Palomino, S. E. Csorna, Amine Ahriche, Simona Toscano, A. Bruno, Jeong-Sook Kim, Kenji Shinozaki, L. Caramete, Marcos Reyes, Roberto Bellotti, K. Mase, Gali Garipov, Joowon Lee, M. Flamini, B. Vlcek, T. Patzak, James H. Adams, H. Prieto, N. Blanc, R. Cremonini, S. Dagoret-Campagne, Francesca Capel, Y. Takizawa, S. Mackovjak, J. L. Marcos, E. Kuznetsov, G. Puehlhofer, D. Supanitsky, R. Weigand Muñoz, P. Gorodetzky, Shoichi Ogio, Johannes Eser, P. Baragatti, Austin Cummings, M. Wille, Y. Uchihori, A. La Barbera, Guillaume Prévôt, S. Blin-Bondil, R. Greg, I. Stan, G. Cordero, Malek Mustafa, J. Mimouni, M. Bogomilov, Z. Polonski, D. Campana, H. Khales, L. Allen, F. Lakhdari, F. Kajino, Maciej Rybczyński, Inkyu Park, M. Putis, S. S. Meyer, A. Weindl, Mark Christl, O. Tibolla, S. Pliego, K. Kawai, Akinori Saito, Ovidiu Vaduvescu, Claudio Cassardo, Dmitri Semikoz, Andrés Merino, P. Carlson, Yuichiro Tameda, John N. Matthews, M. Traïche, F. Cafagna, E. Joven, Y. Hachisu, F. Perfetto, Bruno Spataro, B. Pastirčák, Pierre Barrillon, Eduardo García-Ortega, Sergei A. Sharakin, Piero Vallania, R. Young, Yukihiro Takahashi, José Luis Sánchez, M. D. Sabau, M. Suzuki, Marco Casolino, Claudio Fornaro, Mikhail Panasyuk, A. Neronov, Sergio Fernández-González, J. Bayer, M. C. Maccarone, Valentina Scotti, C. de la Taille, A. Kedadra, I. Dutan, I. S. Zgura, G. Cotto, K. Katahira, M. Mahdi, C. De Donato, Soon-Wook Kim, Yoshimasa Kurihara, G. Chiritoi, H. Schieler, A. Jung, A. Haungs, S. Piraino, H. Lahmar, Antonella Castellina, Mitsuteru Sato, T. Jammer, J. Rabanal, G. Abdellaoui, Hajime Yano, Heungsu Shin, R. Nava, Ralph Engel, Takahiro Fujii, Rossella Caruso, Toshiki Tajima, Hitoshi Ohmori, K. S. Caballero, Hiroyuki Sagawa, Yoshiya Kawasaki, A. Radu, A. Menshikov, Hirohiko M. Shimizu, T. Djemil, D. Allard, Alberto Cellino, S. Kalli, J. Watts, M. E. Bertaina, C. De Santis, L. R. Wiencke, M. Vrabel, P. Prat, Ken'ichi Nomoto, Z. Sahnoune, W. Hidber Cruz, S. Bacholle, Francesco Isgrò, W. Marszał, J. C. Sanchez Balanzar, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Organisation de Micro-Électronique Générale Avancée (OMEGA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Abdellaoui, G., Abe, S., Adams, J., Ahriche, A., Allard, D., Allen, L., Alonso, G., Anchordoqui, L., Anzalone, A., Arai, Y., Asano, K., Attallah, R., Attoui, H., Ave Pernas, M., Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A., Belov, K., Belz, J. W., Benmessai, K., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Blecki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bozzo, E., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J-N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cordero, G., Cotto, G., Crawford, H. J., Cremonini, R., Csorna, S., Cummings, A., Dagoret-Campagne, S., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Djemil, T., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fenu, F., Fernández-González, S., Fernández-Soriano, J., Ferrarese, S., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fujimoto, J., Fukushima, M., Galeotti, P., García-Ortega, E., Garipov, G., Gascón, E., Genci, J., Giraudo, G., González Alvarado, C., Gorodetzky, P., Greg, R., Guarino, F., Guzmán, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Hernández Carretero, J., Hidber Cruz, W., Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kolev, D., Krantz, H., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., La Barbera, A., Lachaud, C., Lahmar, H., Lakhdari, F., Larsson, O., Lee, J., Licandro, J., López Campano, L., Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J., Marini, A., Marszal, W., Martens, K., Martín, Y., Martinez, O., Martucci, M., Masciantonio, G., Mase, K., Mustafa, M., Matev, R., Matthews, J., Mebarki, N., Medina-Tanco, G., Mendoza, M. A., Menshikov, A., Merino, A., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Morales de los Ríos, J. A., Nagataki, S., Naitamor, S., Napolitano, T., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleański, P., Osteria, G., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Polonski, Z., Popescu, E. M., Prat, P., Prévôt, G., Prieto, H., Puehlhofer, G., Putis, M., Rabanal, J., Radu, A. A., Reyes, M., Rezazadeh, M., Ricci, M., Rodríguez Frías, M. D., Ronga, F., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M., Sáez Cano, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sanchez Balanzar, J. C., Sánchez, J. L., Santangelo, A., Sanz-Andrés, A., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, M., Schanz, T., Schieler, H., Scotti, V., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shimizu, H. M., Shin, H. S., Shinozaki, K., Shirahama, T., Sokolsky, P., Spataro, B., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tameda, Y., Tenzer, C., Thomas, S. B., Thomson, G. B., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tubbs, J., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdés-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts, J., Weber, M., Weigand Muñoz, R., Weindl, A., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Yu., Zuccaro Marchi, A., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)
Subjects: Fresnel lens, Photomultiplier, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Night sky, JEM-EUSO, Cosmic ray, Field of view, Astrophysics::Cosmology and Extragalactic Astrophysics, 7. Clean energy, 01 natural sciences, cosmic rays, EAS, UHECR, Astronomy and Astrophysics, Aeronáutica, law.invention, Telescope, law, 0103 physical sciences, Ultra-high-energy cosmic ray, 010303 astronomy & astrophysics, cosmic ray, Astrophysique, Physics, Fresnel len, 010308 nuclear & particles physics, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Astronomie, Astronomía, Limiting magnitude, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: EUSO-TA is a ground-based telescope, installed at the Telescope Array (TA) site in Black Rock Mesa, Utah, USA. This is the first detector to successfully use a Fresnel lens based optical system and multi-anode photomultipliers (64 channels per tube, 2304 channels encompassing a 10.6° × 10.6° field of view) for detection of Ultra High Energy Cosmic Rays (UHECR). The telescope is located in front of one of the fluorescence detectors of the TA experiment. Since its installation in 2013, the detector has observed several ultra-high energy cosmic ray events and, in addition, meteors. The limiting magnitude of 5.5 on summed frames (∼ 3 ms) has been established. Measurements of the UV night sky emission in different conditions and moon phases and positions have been completed. The performed observations serve as a proof of concept for the future application of this detector technology., 0, SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2018
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5. Space fluorescence detection of ultra-high energy cosmic rays based on CORSIKA simulation

Author: Zohra Bouhali and T. Djemil
Subjects: Physics, Nuclear and High Energy Physics, Photon, Calorimeter (particle physics), Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Cosmic ray, law.invention, Computational physics, Atmosphere, Telescope, Air shower, law, Particle, Ultra-high-energy cosmic ray, Instrumentation
Abstract: Using the Earth’s atmosphere as a calorimeter, the air fluorescence light observation technique is commonly used in Ultra-High Energy Cosmic Ray (UHECR) experiments. The aim is to reconstruct the shower cascade curve and to estimate the primary particle energy and its arrival direction. With the help of the CORSIKA air shower simulation program, the development of extensive air showers (EAS), initiated by primary particles entering the Earth’s atmosphere with energies up to 100 EeV, is performed with different combinations of high and low hadronic interaction models. The sensitivity of longitudinal distribution of particles and energy deposited into the air are studied for different simulation parameters. For a space fluorescence telescope aboard the International Space Station (ISS), the number of fluorescence photons and the profile of their arrival times to the detector pupil are calculated for typical extreme energy events.
Published: 2019
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6. Meteor studies in the framework of the JEM-EUSO program

Author: M. Dupieux, S. Bartocci, T. Shibata, Francesco Isgrò, K. Kudela, J. N. Albert, M. Di Martino, A. Marini, S. Blin-Bondil, Frederic Jean Ronga, Mohammed Bakiri, Thomas Schanz, O. Larsson, B. Mot, Silvia Ferrarese, T. Djemil, Alberto Cellino, Livio Conti, K. Martens, G. Osteria, T. Tymieniecka, J. Sledd, G. Cordero, L. R. Wiencke, A. Zuccaro Marchi, G. Roudil, Jörn Wilms, M. Rybczyński, R. Bechini, Patrick J. Reardon, M. Haiduc, Lech Wiktor Piotrowski, Yukihiro Takahashi, José Luis Sánchez, R. Young, O. A. Saprykin, Sug Whan Kim, Y. Karadzhov, M. Nagano, Toshiki Tajima, H. Khales, B. Harlov, Carlo Vigorito, G. Sáez Cano, M. Sakata, Massimiliano Bonamente, A. Belov, T. Shirahama, Marco Casolino, G. Siemieniec-Oziȩbło, Hitoshi Ohmori, Yoshiya Kawasaki, Andreas A. Berlind, Alfonso Monaco, W. Hidber, Claudio Fornaro, Takuji Nakamura, E. Kuznetsov, F. Kanouni, Jianyi Yang, K. Benmessai, Katsuaki Asano, Yoshitaka Itow, Shigeto Watanabe, O. Martinez, J. Błȩcki, Tokonatsu Yamamoto, E. Bozzo, D. Allard, Barbara Szabelska, C. González Alvarado, J. Geary, Mikhail Panasyuk, Shinsuke Abe, Alexander Kusenko, E. M. Popescu, Hajime Yano, S. Yoshida, J. Szabelski, T. Peter, Gustavo Alonso, G. Castellini, M. E. Bertaina, M. Ave Pernas, R. Matev, J. Fujimoto, C. De Santis, Sebastián Franchini, Piotr Orleanski, H. Lim, M. D. Rodríguez Frías, N. Tajima, M. Takeda, Shigehiro Nagataki, A. Neronov, M. C. Maccarone, H. Miyamoto, Ken'ichi Nomoto, F. Dulucq, L. Santiago Crúz, M. Fouka, L. Caramete, M. Suzuki, W. Aouimeur, Amine Ahriche, M. Sanz Palomino, J. F. Valdés-Galicia, L. G. Tkachev, H. Tahi, Satoshi Wada, T. Ogawa, M. C. Talai, K. Słomińska, Markus Roth, K. Shinozaki, Angela V. Olinto, Z. Plebaniak, D. Kolev, M. Flamini, F. Bisconti, L. Mehrad, Michiyuki Chikawa, F. Tajima, A. Kedadra, S. Csorna, G. Vankova, J. Fernández-Soriano, Andrea Santangelo, Gali Garipov, Y. Takizawa, P. L. Biermann, S. Bacholle, D. Maravilla, Humberto Ibarguen Salazar, Valerie Connaughton, R. Guehaz, R. Attallah, P. Gorodetzky, Giuseppe Giraudo, T. Paul, A. Ebersoldt, S. Biktemerova, I. Dutan, Nicusor Arsene, A. Acheli, Piero Vallania, H. Tokuno, Ralph Engel, Fausto Guarino, A. Guzmán, C. Lachaud, I. Rusinov, Toshiyuki Nonaka, B. Vlcek, M. D. Sabau, L. Placidi, M. Wille, A. Sobey, Y. Uchihori, J. Hernández Carretero, A. Nardelli, H. Prieto, M. Kleifges, M. Unger, S. Dagoret-Campagne, C. De Donato, R. Cremonini, P. von Ballmoos, M. Ricci, M. Perdichizzi, Soon-Wook Kim, John N. Matthews, L. Villaseñor, H. Ikeda, Francesco Fenu, Naoto Sakaki, Yoshihiko Mizumoto, G. Masciantonio, Z. Włodarczyk, R. Tsenov, D. Monnier-Ragaigne, A. Segreto, Javier Licandro, Sergio Fernández-González, L. López Campano, Toshitaka Kajino, Belkacem Benadda, Tomás Belenguer, K. Higashide, C. Moretto, P. Galeotti, Valentina Scotti, M. Traïche, G. Medina-Tanco, Marcos Reyes, A. Pollini, Pavel Klimov, B. Panico, Takayuki Tomida, J. Bayer, J. Jochum, Graciela B. Gelmini, N. Blanc, H. Attoui, C. Tenzer, T. Sugiyama, Hajime Takami, H. J. Crawford, J. Karczmarczyk, Tadeusz Wibig, Masaki Fukushima, G. Chiritoi, J. L. Marcos, M. Mahdi, Y. Hachisu, F. Perfetto, A. Jung, F. Cafagna, G. Modestino, Y. Arai, C. de la Taille, T. Pierog, E. Joven, K. Katahira, J. Watanabe, N. Inoue, L. del Peral, A. Franceschi, E. Parizot, Pavol Bobik, D. Kang, D. Ikeda, Isabel Pérez-Grande, Johannes Eser, Y. Yamamoto, M. Rahmani, H. Lahmar, Osvaldo Catalano, B. Pastirčák, Simona Toscano, F. Sarazin, M. Serra, Luis A. Anchordoqui, T. Batsch, Jeong Sook Kim, N. Tone, Daisuke Yonetoku, Marc Weber, J. A. Morales de los Ríos, G. Abdellaoui, Pierre Barrillon, I. Kaneko, P. Baragatti, Ovidiu Vaduvescu, Santiago Pindado, B. A. Khrenov, Eduardo García-Ortega, Estíbaliz Gascón, M. Lacombe, Guillaume Prévôt, Hanna Rothkaehl, M. Yu. Zotov, R. Nava, Piergiorgio Picozza, Sergei A. Sharakin, N. Mebarki, Susumu Inoue, A. Haungs, S. Piraino, Claudio Cassardo, W. Painter, J. Rabanal, Dmitri Semikoz, B. Nadji, J. Mimouni, M. A. Mendoza, D. Campana, I. S. Zgura, Rossella Caruso, F. Lakhdari, M. Bogomilov, V. S. Morozenko, I. V. Yashin, M. Nagata, Inkyu Park, L. Marcelli, M. Putis, Y. Miyazaki, A. Weindl, Andrés Merino, A. Bruno, Yoshimasa Kurihara, J. C. Sanchez, H. Schieler, J. Lee, Antonella Castellina, Mitsuteru Sato, Mark Christl, F. Kajino, T. Jammer, O. Tibolla, Michael S. Briggs, Dmitry V. Naumov, P. Carlson, T. Mernik, T. Patzak, T. Murakami, J.N. Capdevielle, H. W. Park, Francesca Capel, S. Pliego, Thomas J. Weiler, S. Mackovjak, D. Supanitsky, R. Weigand Muñoz, Shoichi Ogio, I. Stan, K. Kawai, Akinori Saito, A. Caramete, K. S. Caballero, Hiroyuki Sagawa, A. Radu, Maxim Gonchar, Hirohiko M. Shimizu, S. A. Djenas, S. Kalli, J. Watts, C. Pennypacker, M. Vrabel, P. Prat, Z. Sahnoune, M. Karus, Domenico Finco, Roberto Bellotti, K. Mase, James H. Adams, H. Sato, Octavian Micu, E. G. Judd, Katsuhiko Tsuno, I. Kreykenbohm, Vladimir Andreev, Y. Martín, S. Ahmad, A. Anzalone, T. Napolitano, Christer Fuglesang, José Meseguer, Angel Sanz-Andrés, Y. Tsunesada, J. Genci, K. Belov, C. Catalano, M. Rezazadeh, S. Selmane, Toshikazu Ebisuzaki, S. Messaoud, Ke Fang, R. Boudaoud, Abdellaoui, G., Abe, S., Acheli, A., Adams, J. H., Ahmad, S., Ahriche, A., Albert, J. N., Allard, D., Alonso, G., Anchordoqui, L., Andreev, V., Anzalone, A., Aouimeur, W., Arai, Y., Arsene, N., Asano, K., Attallah, R., Attoui, H., Ave Pernas, M., Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Batsch, T., Bayer, J., Bechini, R., Belenguer, T., Bellotti, R., Belov, A., Belov, K., Benadda, B., Benmessai, K., Berlind, A. A., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Błȩcki, J., Blin Bondil, S., Bobik, P., Bogomilov, M., Bonamente, M., Boudaoud, R., Bozzo, E., Briggs, M. S., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J. N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Castellini, G., Catalano, C., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cordero, G., Crawford, H. J., Cremonini, R., Csorna, S., Dagoret Campagne, S., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Djemil, T., Djenas, S. A., Dulucq, F., Dupieux, M., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fang, K., Fenu, F., Fernández González, S., Fernández Soriano, J., Ferrarese, S., Finco, D., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujimoto, J., Fukushima, M., Galeotti, P., García Ortega, E., Garipov, G., Gascón, E., Geary, J., Gelmini, G., Genci, J., Giraudo, G., Gonchar, M., González Alvarado, C., Gorodetzky, P., Guarino, Fausto, Guehaz, R., Guzmán, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Hernández Carretero, J., Hidber, W., Higashide, K., Ikeda, D., Ikeda, H., Inoue, N., Inoue, S., Isgro', Francesco, Itow, Y., Jammer, T., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Kang, D., Kanouni, F., Karadzhov, Y., Karczmarczyk, J., Karus, M., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong Sook, Kim, Soon Wook, Kim, Sug Whan, Kleifges, M., Klimov, P. A., Kolev, D., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lacombe, M., Lachaud, C., Lahmar, H., Lakhdari, F., Larsson, O., Lee, J., Licandro, J., Lim, H., López Campano, L., Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Martens, K., Martín, Y., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Matthews, J. N., Mebarki, N., Medina Tanco, G., Mehrad, L., Mendoza, M. A., Merino, A., Mernik, T., Meseguer, J., Messaoud, S., Micu, O., Mimouni, J., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monaco, A., Monnier Ragaigne, D., Morales de los Ríos, J. A., Moretto, C., Morozenko, V. S., Mot, B., Murakami, T., Nadji, B., Nagano, M., Nagata, M., Nagataki, S., Nakamura, T., Napolitano, T., Nardelli, A., Naumov, D., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleański, P., Osteria, G., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Park, H. W., Pastircak, B., Patzak, T., Paul, T., Pennypacker, C., Perdichizzi, M., Pérez Grande, I., Perfetto, Francesco, Peter, T., Picozza, P., Pierog, T., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Popescu, E. M., Prat, P., Prévôt, G., Prieto, H., Putis, M., Rabanal, J., Radu, A. A., Rahmani, M., Reardon, P., Reyes, M., Rezazadeh, M., Ricci, M., Rodríguez Frías, M. D., Ronga, F., Roth, M., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M. D., Sáez Cano, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Sakata, M., Salazar, H., Sanchez, J. C., Sánchez, J. L., Santangelo, A., Santiago Crúz, L., Sanz Andrés, A., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, H., Sato, M., Schanz, T., Schieler, H., Scotti, Valentina, Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec Oziȩbło, G., Sledd, J., Słomińska, K., Sobey, A., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tahi, H., Tajima, F., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tymieniecka, T., Uchihori, Y., Unger, M., Vaduvescu, O., Valdés Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watanabe, S., Null, J. Watts J. r., Weber, M., Weigand Muñoz, R., Weindl, A., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yamamoto, Y., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S, Zotov, M. Y. u., and Zuccaro Marchi, A.
Subjects: Physics, Meteor (satellite), Mini-EUSO, 010504 meteorology & atmospheric sciences, Meteors, JEM-EUSO, EUSO-TA, Astronomy, Nuclearites, Astronomy and Astrophysics, 01 natural sciences, Preliminary analysis, Aeronáutica, Space and Planetary Science, 0103 physical sciences, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Remote sensing
Abstract: 著者人数: 360名 (JAXA職員: 池田, 博一 ; 鈴木, 睦 ; 矢野, 創), Accepted: 2016-12-08, 資料番号: SA1170070000
Published: 2017
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7. Cosmic ray oriented performance studies for the JEM-EUSO first level trigger

Author: H. Sato, T. Djemil, Alberto Cellino, Octavian Micu, Javier Licandro, M. D. Rodríguez Frías, Z. Plebaniak, N. Guardone, Katsuhiko Tsuno, A. Belov, L. R. Wiencke, N. Tone, G. Cordero, A. Anzalone, T. Napolitano, Michiyuki Chikawa, Katsuaki Asano, A. Ebersoldt, Daisuke Yonetoku, I. S. Zgura, Roberto Bellotti, M. Mahdi, T. Pierog, Yoshimasa Kurihara, H. Schieler, E. M. Popescu, Antonella Castellina, Mitsuteru Sato, T. Jammer, K. S. Caballero, Hiroyuki Sagawa, Christer Fuglesang, J. Watanabe, G. Roudil, K. Mase, Graciela B. Gelmini, G. Chiritoi, Y. Hachisu, F. Perfetto, Y. Yamamoto, B. Pastirčák, J. Geary, H. Khales, José Meseguer, Angel Sanz-Andrés, Osvaldo Catalano, Santiago Pindado, Junpei Fujimoto, B. A. Khrenov, S. Pliego, Thomas J. Weiler, Pierre Barrillon, Eduardo García-Ortega, Sergei A. Sharakin, Massimiliano Bonamente, James H. Adams, Y. Tsunesada, H. Lahmar, Patrick J. Reardon, Toshiki Tajima, G. Siemieniec-Oziȩbło, Satoshi Wada, T. Ogawa, M. Yu. Zotov, J. Genci, Piergiorgio Picozza, N. Mebarki, Mohammed Bakiri, C. Catalano, K. Benmessai, M. Suzuki, Valentina Scotti, Hitoshi Ohmori, G. Abdellaoui, Francesco Isgrò, Daisuke Ikeda, Belkacem Benadda, W. Painter, P. Gorodetzky, Yoshiya Kawasaki, E. Kuznetsov, Yoshihiko Mizumoto, R. Bechini, M. C. Talai, C. De La Taille, K. Shinozaki, A. Radu, F.J. Ronga, Alfonso Monaco, Shinsuke Abe, B. Nadji, E. Parizot, A. Guzmán, Toshitaka Kajino, K. Kawai, Ralph Engel, I. Kreykenbohm, Hajime Takami, Angela V. Olinto, Andrea Santangelo, D. Maravilla, S. Blin-Bondil, D. Allard, Vladimir Andreev, Masaki Fukushima, R. Nava, V. S. Morozenko, Akinori Saito, Maxim Gonchar, Hirohiko M. Shimizu, M. A. Mendoza, E. G. Judd, D. Kang, G. Castellini, Andreas A. Berlind, M. Rezazadeh, S. Selmane, Alexander Kusenko, K. Higashide, C. Moretto, P. Galeotti, Y. Martín, M. E. Bertaina, L. Villaseñor, C. De Santis, J. Yang, Rossella Caruso, J. Karczmarczyk, Shigeto Watanabe, Ken'ichi Nomoto, K. Słomińska, H. Attoui, C. Tenzer, F Dulucq, N. Inoue, S. Bacholle, John N. Matthews, Francesca Capel, J. F. Valdés-Galicia, L. G. Tkachev, H. Tahi, G. Vankova, Tokonatsu Yamamoto, Guillaume Prévôt, L. del Peral, A. Franceschi, Pavol Bobik, T. Sugiyama, Hajime Yano, Tadeusz Wibig, B. Mot, S. Dagoret-Campagne, S. Bartocci, E. Bozzo, M. Serra, Luis A. Anchordoqui, T. Shibata, M. Traïche, S. Mackovjak, J. Fernández-Soriano, D. Supanitsky, T. Batsch, Toshio Murakami, R. Young, M. Sakata, S. Biktemerova, Toshikazu Ebisuzaki, Yukihiro Takahashi, José Luis Sánchez, S. Ahmad, C. Lachaud, F. Cafagna, H. J. Crawford, O. Larsson, S. Messaoud, K. Kudela, G. Modestino, E. Joven, M. Rahmani, Giuseppe Giraudo, R. Weigand Muñoz, T. Shirahama, S. A. Djenas, S. Kalli, I. Kaneko, A. Haungs, S. Piraino, J. Watts, Hanna Rothkaehl, J. Mimouni, J. A. Morales de los Ríos, Toshiyuki Nonaka, Ovidiu Vaduvescu, M. Karus, L. Santiago Crúz, M. Bogomilov, Josef Jochum, F. Bisconti, M. Lacombe, Claudio Cassardo, Shoichi Ogio, M. Flamini, Silvia Ferrarese, C. Pennypacker, Marco Casolino, Claudio Fornaro, Susumu Inoue, Tomás Belenguer, J. Błȩcki, L. Mehrad, M. Vrabel, P. Prat, Piotr Orleanski, Ke Fang, Mikhail Panasyuk, F. Kajino, Andrés Merino, Y. Takizawa, M. Fouka, P. L. Biermann, Z. Sahnoune, D. Kolev, H. Lim, J. C. Sanchez, Maciej Rybczyński, G. Sáez Cano, D. Monnier-Ragaigne, A. Segreto, W. Aouimeur, A. Neronov, M. C. Maccarone, B. Harlov, I. Rusinov, P. Carlson, T. Mernik, A. Jung, H. W. Park, R. Boudaoud, M. Dupieux, I. V. Yashin, Carlo Vigorito, Domenico Finco, A. Kedadra, T. Paul, Valerie Connaughton, Marcos Reyes, R. Guehaz, N. Blanc, M. Ave Pernas, T. Nakamura, Yoshio Arai, L. Marcelli, I. Dutan, L. Placidi, A. Sobey, Francesco Fenu, Piero Vallania, S. E. Csorna, G. Masciantonio, G. Medina-Tanco, J. L. Marcos, M. D. Sabau, Johannes Eser, H. Prieto, R. Cremonini, H. Ikeda, Naoto Sakaki, G. Cotto, Markus Roth, C. De Donato, L. López Campano, Sergio Fernández-González, Takayuki Tomida, Nicusor Arsene, J. Bayer, A. Insolia, M. Kleifges, N. Tajima, M. Takeda, Soon-Wook Kim, J. Rabanal, J. Hernández Carretero, Fausto Guarino, P. von Ballmoos, M. Ricci, A. Bruno, M. Unger, Shigehiro Nagataki, K. Katahira, Isabel Pérez-Grande, F. Sarazin, Zbigniew Wlodarczyk, Marc Weber, R. Matev, Simona Toscano, Michael S. Briggs, M. Haiduc, Lech Wiktor Piotrowski, S. Yoshida, J. Szabelski, Estíbaliz Gascón, O. Martinez, T. Patzak, M. Nagata, Dmitry V. Naumov, J.N. Capdevielle, I. Stan, A. Caramete, K. Martens, Konstantin Belov, Joowon Lee, F. Tajima, A. Acheli, J. N. Albert, Thomas Schanz, M. Wille, Livio Conti, Y. Uchihori, A. Zuccaro Marchi, Jörn Wilms, O. A. Saprykin, Sug Whan Kim, F. Kanouni, Sebastián Franchini, Gali Garipov, R. Attallah, D. Campana, F. Lakhdari, Barbara Szabelska, Inkyu Park, M. Putis, Y. Miyazaki, A. Weindl, T. Peter, B. Vlcek, Mark Christl, Gustavo Alonso, O. Tibolla, Jeong Sook Kim, C. González Alvarado, P. Baragatti, H. Miyamoto, M. Manfrin, Yoshitaka Itow, L. Caramete, M. Sanz Palomino, Y. Karadzhov, Amine Ahriche, Humberto Ibarguen Salazar, G. Contino, H. Tokuno, W. Hidber, R. Tsenov, R. Forza, A. Pollini, Pavel Klimov, B. Panico, M. Mignone, M. Di Martino, A. Marini, G. Osteria, D.V. Semikoz, T. Tymieniecka, J. Sledd, M. Nagano, Abdellaoui, G., Abe, S., Acheli, A., Adams, J. H., Ahmad, S., Ahriche, A., Albert, J. N., Allard, D., Alonso, G., Anchordoqui, L., Andreev, V., Anzalone, A., Aouimeur, W., Arai, Y., Arsene, N., Asano, K., Attallah, R., Attoui, H., Ave pernas, M., Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Batsch, T., Bayer, J., Bechini, R., Belenguer, T., Bellotti, R., Belov, A., Belov, K., Benadda, B., Benmessai, K., Berlind, A. A., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Błȩcki, J., Blin Bondil, S., Bobik, P., Bogomilov, M., Bonamente, M., Boudaoud, R., Bozzo, E., Briggs, M. S., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J. N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Castellini, G., Catalano, C., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Contino, G., Cordero, G., Cotto, G., Crawford, H. J., Cremonini, R., Csorna, S., Dagoret Campagne, S., De donato, C., De la taille, C., De santis, C., Del peral, L., Di martino, M., Djemil, T., Djenas, S. A., Dulucq, F., Dupieux, M., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fang, K., Fenu, F., Fernández González, S., Fernández Soriano, J., Ferrarese, S., Finco, D., Flamini, M., Fornaro, C., Forza, R., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujimoto, J., Fukushima, M., Galeotti, P., García Ortega, E., Garipov, G., Gascón, E., Geary, J., Gelmini, G., Genci, J., Giraudo, G., Gonchar, M., González alvarado, C., Gorodetzky, P., Guardone, N., Guarino, Fausto, Guehaz, R., Guzmán, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Hernández carretero, J., Hidber, W., Higashide, K., Ikeda, D., Ikeda, H., Inoue, N., Inoue, S., Insolia, A., Isgro', Francesco, Itow, Y., Jammer, T., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Kang, D., Kanouni, F., Karadzhov, Y., Karczmarczyk, J., Karus, M., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong Sook, Kim, Soon Wook, Kim, Sug Whan, Kleifges, M., Klimov, P. A., Kolev, D., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lacombe, M., Lachaud, C., Lahmar, H., Lakhdari, F., Larsson, O., Lee, J., Licandro, J., Lim, H., López campano, L., Maccarone, M. C., Mackovjak, S., Mahdi, M., Manfrin, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Martens, K., Martín, Y., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Matthews, J. N., Mebarki, N., Medina Tanco, G., Mehrad, L., Mendoza, M. A., Merino, A., Mernik, T., Meseguer, J., Messaoud, S., Micu, O., Mignone, M., Mimouni, J., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monaco, A., Monnier Ragaigne, D., Morales de los ríos, J. A., Moretto, C., Morozenko, V. S., Mot, B., Murakami, T., Nadji, B., Nagano, M., Nagata, M., Nagataki, S., Nakamura, T., Napolitano, T., Naumov, D., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleański, P., Osteria, G., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Park, H. W., Pastircak, B., Patzak, T., Paul, T., Pennypacker, C., Pérez Grande, I., Perfetto, Francesco, Peter, T., Picozza, P., Pierog, T., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Popescu, E. M., Prat, P., Prévôt, G., Prieto, H., Putis, M., Rabanal, J., Radu, A. A., Rahmani, M., Reardon, P., Reyes, M., Rezazadeh, M., Ricci, M., Rodríguez frías, M. D., Ronga, F., Roth, M., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M. D., Sáez cano, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Sakata, M., Salazar, H., Sanchez, J. C., Sánchez, J. L., Santangelo, A., Santiago crúz, L., Sanz Andrés, A., Sanz palomino, M., Saprykin, O., Sarazin, F., Sato, H., Sato, M., Schanz, T., Schieler, H., Scotti, Valentina, Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec Oziȩbło, G., Sledd, J., Słomińska, K., Sobey, A., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tahi, H., Tajima, F., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tymieniecka, T., Uchihori, Y., Unger, M., Vaduvescu, O., Valdés Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villaseñor, L., Vlcek, B., Von ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watanabe, S., Watts, J., Weber, M., Weigand muñoz, R., Weindl, A., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yamamoto, Y., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Y. u., Zuccaro marchi, A., Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)
Subjects: Nuclear and High Energy Physics, data analysis method, Instrumentation, Astrophysics::High Energy Astrophysical Phenomena, Night sky, measurement methods, satellite, JEM-EUSO, FPGA, Nightglow background, Trigger system, Cosmic ray, 01 natural sciences, law.invention, Aeronáutica, Telescope, nightglow background, law, 0103 physical sciences, International Space Station, cosmic radiation: UHE, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010303 astronomy & astrophysics, background: suppression, Remote sensing, Physics, detector: wide-angle, trigger system, laser: pulsed, showers: atmosphere, 010308 nuclear & particles physics, Astrophysics::Instrumentation and Methods for Astrophysics, trigger, Astronomía, Satellite, background: fluctuation, FPGA, JEM-EUSO, Nightglow background, Trigger system, Nuclear and High Energy Physics, Instrumentation, Neutrino, Energy (signal processing), performance
Abstract: 著者人数: 368名 (JAXA職員: 池田, 博一 ; 鈴木, 睦 ; 矢野, 創), Accepted: 2017-05-29, 資料番号: SA1170117000
Published: 2017
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8. Simulation of the fluorescence signal detected by a space telescope for extreme energy cosmic ray observations

Author: Zohra Bouhali and T. Djemil
Subjects: Physics, Photon, 010308 nuclear & particles physics, Scattering, QC1-999, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Diffuse sky radiation, Cosmic ray, 01 natural sciences, Charged particle, law.invention, Computational physics, Telescope, Wavelength, Spitzer Space Telescope, law, 0103 physical sciences, 010303 astronomy & astrophysics
Abstract: The experimental technique of fluorescence light measurement is used for indirect observations of cosmic ray particles at very high energies. Extensive Air Showers (EAS) initiated by Extreme Energy Cosmic Rays (EECRs), up to 100 EeV and entering the Earth’s atmosphere, are simulated with the CORSIKA package. The influence of different simulation parameters on the EAS characteristics is studied, especially on the longitudinal distribution of charged particles, depth of shower maximum and energy released to the air. By taking the atmospheric scattering of light into account, the number of fluorescence photons, with wavelengths between 300-430 nm, and their arrival time distribution to an ideal space telescope are calculated.
Published: 2019
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9. Monte Carlo calculation of the atmospheric antinucleon flux

Author: T. Djemil, J.N. Capdevielle, R. Attallah, APC - Astrophysique des Hautes Energies (APC - AHE), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)
Subjects: Physics, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Nuclear and High Energy Physics, 010308 nuclear & particles physics, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Monte Carlo method, Antineutron, 01 natural sciences, 7. Clean energy, Atomic and Molecular Physics, and Optics, Nuclear physics, Earth's magnetic field, Antiproton, 0103 physical sciences, Dynamic Monte Carlo method, Monte Carlo method in statistical physics, Direct simulation Monte Carlo, Nuclear Experiment, Nucleon, 010303 astronomy & astrophysics
Abstract: International audience; The atmospheric antiproton and antineutron energy spectra are calculated at float altitude using the CORSIKA package in a three-dimensional Monte Carlo simulation. The hadronic interaction is treated by the FLUKA code below 80 GeV/nucleon and NEXUS elsewhere. The solar modulation which is described by the force field theory and the geomagnetic effects are taken into account. The numerical results are compared with the BESS-2001 experimental data.
Published: 2009
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10. [Composition of 359 kidney stones from the East region of Algeria]

Author: S, Bouslama, A, Boutefnouchet, B, Hannache, T, Djemil, A, Kadi, A, Dahdouh, S, Saka, and M, Daudon
Subjects: Adult, Male, Calcium Oxalate, Struvite, Magnesium Compounds, Middle Aged, Antioxidants, Hemostatics, Hospitals, Phosphates, Uric Acid, Kidney Calculi, Risk Factors, Algeria, Apatites, Spectroscopy, Fourier Transform Infrared, Prevalence, Humans, Female, Sex Distribution, Aged, Retrospective Studies
Abstract: Determine stones composition of the upper urinary tract in the eastern region of Algeria.Our study focuses on a set of 359 stones of the upper urinary tract collected between January 2007 and December 2012 at hospitals in the eastern region of Algeria and analyzed by Fourier transform infrared spectroscopy.The male/female ratio was only 1.32. Calcium oxalate prevailed in 68.5% of stones and 49.3% of nuclei, mainly as whewellite (51.8% of stones and 37.9% of nuclei vs 16.7% and 11.4% respectively for weddellite). Carbapatite prevailed in 15% of stones and 29.8% of nuclei. The struvite, identified in 11.1% of calculi, prevailed in 3.9% of stones and 3.1% of nuclei. Among purines, uric acid prevailed with frequencies quite close to 8.9% and 7% respectively in the stone and in the nucleus while the ammonium urate prevailed in only 0.3% of stones and 3.3% of nuclei. The cystine frequency was 3.6% in both stone and nucleus. The frequency of stone with umbilication was 26.2%. Whewellite was the main component of umbilicated stones with Randall's plaque.Our results suggest that stones of the urinary tract in the Algerian east region resemble those observed in industrialized countries. Some features such as stones location, the whewellite prevalence, the frequencies of main components in both the stone and the nucleus as well as the formation of stones on renal papilla confirm this trend.4.
Published: 2015

11. Sensitivity of atmospheric muon flux calculation to low energy hadronic interaction models

Author: J.N. Capdevielle, R. Attallah, T. Djemil, APC - Astrophysique des Hautes Energies (APC - AHE), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Dipartimento di Astronomia, Universita degli Studi di Bologna, and Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO)
Subjects: Physics, Nuclear and High Energy Physics, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], 010504 meteorology & atmospheric sciences, Astrophysics::High Energy Astrophysical Phenomena, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Hadron, Nuclear Theory, Cosmic ray, 01 natural sciences, 7. Clean energy, Force field (chemistry), Spectral line, International Standard Atmosphere, Nuclear physics, Air shower, 13. Climate action, 0103 physical sciences, Muon flux, High Energy Physics::Experiment, Nucleon, Nuclear Experiment, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences
Abstract: We investigate in this paper the impact of some up-to-date hadronic interaction models on the calculation of the atmospheric muon flux. Calculations are carried out with the air shower simulation code CORSIKA in combination with the hadronic interaction models FLUKA and UrQMD below 80 GeV/nucleon and NEXUS elsewhere. We also examine the atmospheric effects using two different parametrizations of the US standard atmosphere. The cosmic ray spectra of protons and α particles, the only primary particles considered here, are taken according to the force field model which describes properly solar modulation. Numerical results are compared with the BESS-2001 experimental data.
Published: 2007
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12. Simulation of the Atmospheric Muon Flux with CORSIKA

Author: T. Djemil, J.N. Capdevielle, R. Attallah, Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Physics, Nuclear and High Energy Physics, High energy, biology, 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, CORSIKA, Hadron, Atmospheric muons, Astronomy and Astrophysics, Venus, biology.organism_classification, 01 natural sciences, 7. Clean energy, Atomic and Molecular Physics, and Optics, Lower energy, Nuclear physics, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Air shower, 13. Climate action, 0103 physical sciences, Muon flux, High Energy Physics::Experiment, 010306 general physics, Zenith
Abstract: We present in this paper the results of 3D-calculation of the atmospheric muon flux at different altitudes. We have used for this purpose the extensive air shower simulation package CORSIKA (v. 6.031) in combination with the hadronic interaction models VENUS (v. 4.12) at high energy (beyond 80 GeV) and GHEISHA (v. 2002) and UrQMD (v. 1.1) at lower energy. Our results are compared to data from different experiments (CAPRICE, BESS and HEAT). The correlation of the atmospheric muon flux to the primary zenith angle and primary energy is also investigated.
Published: 2004
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13. The Efficacy of External Beam Radiotherapy and Stereotactic Body Radiotherapy (SBRT) for Painful Spinal Metastases from Renal Cell Carcinoma

Author: G.K. Hunter, E.H. Balagamwala, S.A. Koyfman, T. Bledsoe, C.A. Reddy, T. Djemil, S.T. Chao, L. Angelov, and G.M.M. Videtic
Subjects: Cancer Research, Radiation, Oncology, Radiology, Nuclear Medicine and imaging
Published: 2011
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14. Recursive Partitioning Analysis Index is Predictive for Overall Survival in Patients Undergoing Spine Stereotactic Body Radiation Therapy for Spinal Metastases

Author: S.T. Chao, S.A. Koyfman, N. Woody, L. Angelov, S. Soeder, C.A. Reddy, L. Rybicki, T. Djemil, and J.H. Suh
Subjects: Cancer Research, Radiation, Oncology, Radiology, Nuclear Medicine and imaging
Published: 2010
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15. 187 IMRT Treatment with Respiratory Gating. Renal lesion: a case study

Author: A. Mahadevan, Lee Ponsky, and T. Djemil
Subjects: Renal lesion, medicine.medical_specialty, Oncology, business.industry, Respiratory gating, Medicine, Radiology, Nuclear Medicine and imaging, Hematology, Radiology, business
Published: 2005
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16. Flux of antinucleons induced by cosmic rays in the atmosphere

Author: T. Djemil, R. Attallah, and J.N. Capdevielle
Subjects: Physics, History, Work (thermodynamics), Antiparticle, Range (particle radiation), Astrophysics::High Energy Astrophysical Phenomena, Cosmic ray, Kinetic energy, Spectral line, Computer Science Applications, Education, Nuclear physics, Atmosphere, Antiproton, High Energy Physics::Experiment
Abstract: This work is devoted to the calculation of the fluxes of the atmospheric antiprotons and antineutrons generated at various atmospheric depths, lying from 5 to 300 g/cm2. The simulations are carried out with the help of CORSIKA package involving a primary energy spectrum starting at the energy threshold of antiparticle production up to 1 PeV. The obtained results match well with the atmospheric antiproton spectra measured by the BESS-2001 experiment in the kinetic energy range 1-3 GeV.
Published: 2013
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17. Prediction of Chest Wall Toxicity after Lung Stereotactic Body Radiotherapy (SBRT)

Author: K. Stephans, T. Djemil, R. Tendulkar, C. Robinson, C. Reddy, and G. Videtic
Subjects: Cancer Research, Radiation, Oncology, Radiology, Nuclear Medicine and imaging
Published: 2009
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18. Sensitivity of atmospheric muon flux calculation to low energy hadronic interaction models.

Author: T Djemil, R Attallah, and J N Capdevielle
Subjects: *FLUX (Metallurgy), *PARTICLES (Nuclear physics), *NUCLEAR physics, *COSMIC rays
Abstract: We investigate in this paper the impact of some up-to-date hadronic interaction models on the calculation of the atmospheric muon flux. Calculations are carried out with the air shower simulation code CORSIKA in combination with the hadronic interaction models FLUKA and UrQMD below 80 GeV/nucleon and NEXUS elsewhere. We also examine the atmospheric effects using two different parametrizations of the US standard atmosphere. The cosmic ray spectra of protons and a particles, the only primary particles considered here, are taken according to the force field model which describes properly solar modulation. Numerical results are compared with the BESS-2001 experimental data. [ABSTRACT FROM AUTHOR]
Published: 2007
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19. SU‐FF‐T‐414: Transfer of Brain Tumor Patients From Leksell Gamma Knife to BrainLAB Novalis.

Author: T Djemil, J Suh, G Neyman, M Weinhous, and M Ouzidane
Published: 2005

20. Treatment plan quality and delivery accuracy assessments on 3 IMRT delivery methods of stereotactic body radiotherapy for spine tumors.

Author: Huang L, Djemil T, Zhuang T, Andrews M, Chao ST, Suh JH, and Xia P
Subjects: Humans, Radiosurgery methods, Radiotherapy Planning, Computer-Assisted methods, Radiotherapy, Intensity-Modulated methods, Spinal Neoplasms radiotherapy
Abstract: Stereotactic body radiotherapy (SBRT) for spine tumors has demonstrated clinical effectiveness. The treatment planning and delivery techniques have evolved from dynamic conformal arc therapy, to fixed gantry angle intensity modulated radiotherapy (IMRT), and most recently to volumetric modulated arc therapy (VMAT). A hybrid-arc (HARC) planning and delivery method combining dynamic conformal arc therapy delivery with a number of equally spaced IMRT beams is proposed. In this study we investigated plan quality, delivery accuracy, and efficiency of 3 delivery techniques: IMRT, HARC, and VMAT. Patients who underwent spine SBRT treatments were randomly selected from an Institutional Review Board-approved registry. For each patient, the prescription dose was 14 to 16 Gy in a single fraction to cover >90% of the tumor (without planning margin) while constraining V 10Gy ≤ 10% of the spinal cord and the maximum point dose (MPD) of the spinal cord ≤ 14 Gy. All cases were clinically treated with fixed gantry step-shoot IMRT plans and then re-planned with VMAT using Pinnacle 9.0 and with HARC using Brainlab iPlan 4.5. Student t-test was used to compare the dosimetric end points, including V 16Gy to the planning target volume, homogeneity index, MPD PTV , the conformity index, V 10Gy of the spinal cord, and MPD cord . To compare the accuracy of delivery, we delivered all plans on a phantom and conducted gamma index (GI) comparisons with 3 mm/3% and 2 mm/2% criteria. All plans met our clinical requirements. Among 3 techniques, there were no differences on dose coverage to the tumor volume, maximum dose to the spinal cord, and plan homogeneity index (p > 0.05). The average V 10Gy of the spinal cord was 6.66 ± 0.03%, 5.49 ± 0.03%, and 4.76 ± 0.02% for IMRT, HARC, and VMAT plans, respectively. Accordingly, the conformity indices were 1.30 ± 0.11 and 1.29 ± 0.20, 1.53 ± 0.29, respectively. VMAT plans were significantly (p < 0.05) less conformal but significantly (p < 0.05) lower V 10Gy of the spinal cord than those from HARC and IMRT plans. With delivery accuracy measured by GIs, the average GIs of 3%/3 mm were 92.6 ± 1.1%, 96.5 ± 2.7%, 99.0 ± 1.1% for IMRT, HARC, and VMAT plans, respectively. The differences were significant (p < 0.05). Accordingly, the average monitor units were 9238 ± 2242, 9853 ± 2548 and 5091 ± 910. The plan quality created from the 3 planning techniques can meet the clinical requirement. Adding arc beams in delivery such as in HARC and VMAT plans improves the delivery accuracy. VMAT is the most efficient delivery method., (Copyright © 2018 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.)
Published: 2019
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21. Dosimetric differences between local failure and local controlled non-small cell lung cancer patients treated with stereotactic body radiotherapy: A matched-pair study.

Author: Zhuang T, Woody NM, Liu H, Cherian S, Reddy CA, Qi P, Magnelli A, Djemil T, Stephans KL, Xia P, and Videtic GM
Subjects: Aged, Aged, 80 and over, Algorithms, Dose Fractionation, Radiation, Female, Humans, Male, Matched-Pair Analysis, Middle Aged, Monte Carlo Method, Radiotherapy Dosage, Registries, Retrospective Studies, Treatment Outcome, Tumor Burden, Carcinoma, Non-Small-Cell Lung radiotherapy, Lung Neoplasms radiotherapy, Radiosurgery
Abstract: Introduction: Concerns were raised about the accuracy of pencil beam (PB) calculation and potential underdosing of medically inoperable non-small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT). From our institutional series, we designed a matched-pair study where each local failure and controlled patient was matched based upon several clinical factors, to investigate the dose difference between the matched-pair., Methods: Eighteen pairs of NSCLC patients, treated with 50 Gy in five fractions, were selected. These patients were matched based on treatment intent, tumour size, histology and clinical follow-up. All PB calculated clinical plans were retrospectively recalculated with a MC algorithm. The D 99 and D M ean of the gross tumour volume (GTV) and D 95 and D M ean of the planning tumour volume (PTV) from PB and Monte Carlo (MC) calculation were compared between local failures and controls using the Mann-Whitney test., Results: The mean PB calculated D95 of PTV was 50.4 Gy for both failures and controls (P = 0.85), indicating no planning differences between the groups. From MC calculations, the mean (±SD) of GTV D 99 , GTV D M ean , PTV D 95 , PTV D M ean were 47.6 ± 2.6/46.3 ± 2.4, 50.4 ± 2.1/49.8 ± 1.6, 44.4 ± 2.7/43.6 ± 3.1, 48.7 ± 2.4/48.2 ± 2.4 Gy for failure/controlled groups, respectively, and there was no significant difference between two groups (all P > 0.1). The dose differences between MC and PB calculations were in agreement with other literatures and there was no significant difference between two groups., Conclusions: While PB algorithms may overestimate tumour doses relative to MC algorithms, our matched-pair study did not find dose differences between local failure and local controlled cases., (© 2018 The Royal Australian and New Zealand College of Radiologists.)
Published: 2018
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22. Recursive partitioning analysis is predictive of overall survival for patients undergoing spine stereotactic radiosurgery.

Author: Balagamwala EH, Miller JA, Reddy CA, Angelov L, Suh JH, Tariq MB, Murphy ES, Yang K, Djemil T, Magnelli A, Mohammadi AM, Soeder S, and Chao ST
Subjects: Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Spinal Neoplasms mortality, Spinal Neoplasms secondary, Radiosurgery, Spinal Neoplasms diagnosis, Spinal Neoplasms radiotherapy
Abstract: Spine stereotactic radiosurgery (SRS) offers excellent radiographic and pain control for patients with spine metastases. We created a prognostic index using recursive partitioning analysis (RPA) to allow better patient selection for spine SRS. Patients who underwent single-fraction spine SRS for spine metastases were included. Primary histologies were divided into favorable (breast/prostate), radioresistant (renal cell/sarcoma/melanoma) and other. Cox proportional hazards regression was done to identify factors associated with overall survival (OS). RPA was performed to identify factors to classify patients into distinct risk groups with respect to OS. A total of 444 patients were eligible. Median dose was 16 Gy (range 8-18) in 1 fraction and median follow-up was 11.7 months. At time of analysis, 103 (23.1%) patients were alive. Median OS was 12.9 months. RPA identified three distinct classes. Class 1 was defined as KPS > 70 with controlled systemic disease (n = 142); class 3 was defined as KPS ≤ 70 and age < 54 years or KPS ≤ 70 age ≥ 54 years and presence of visceral metastases (n = 95); all remaining patients comprise class 2 (n = 207). Median overall survival was 26.7 months for class 1, 13.4 months for class 2, and 4.5 months for class 3 (p < 0.01). Our analysis demonstrates that there is considerably variability in survival among patients undergoing spine SRS. We created an objective risk stratification via RPA for spine SRS. Given the safety and efficacy of spine SRS and good survival in class 1 and 2 patients, this RPA can help clinicians identify patients who may benefit from upfront spine SRS.
Published: 2018
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23. Volumetric-based image guidance is superior to marker-based alignments for stereotactic body radiotherapy of prostate cancer.

Author: Li W, Lu L, Stephans KL, Sharma N, Vassil A, Shen ZL, Stockham A, Djemil T, Tendulkar RD, and Xia P
Subjects: Humans, Male, Prognosis, Prostatic Neoplasms diagnostic imaging, Prostatic Neoplasms pathology, Radiotherapy Dosage, Radiotherapy, Intensity-Modulated methods, Cone-Beam Computed Tomography methods, Organs at Risk radiation effects, Prostatic Neoplasms surgery, Radiosurgery methods, Radiotherapy Planning, Computer-Assisted methods, Surgery, Computer-Assisted methods
Abstract: Purposes: The aim of this study was to evaluate a dual marker-based and soft-tissue based image guidance for inter-fractional corrections in stereotactic body radiotherapy (SBRT) of prostate cancer., Methods/materials: We reviewed 18 patients treated with SBRT for prostate cancer. An endorectal balloon was inserted at simulation and each treatment. Planning margins were 3 mm/0 mm posteriorly. Prior to each treatment, a dual image guidance protocol was applied to align three makers using stereoscopic x ray images and then to the soft tissue using kilo-voltage cone beam CT (kV-CBCT). After treatment, prostate (CTV), rectal wall, and bladder were delineated on each kV-CBCT, and delivered dose was recalculated. Dosimetric endpoints were analyzed, including V 36.25 Gy for prostate, and D 0.03 cc for bladder and rectal wall., Results: Following initial marker alignment, additional translational shifts were applied to 22 of 84 fractions after kV-CBCT. Among the 22 fractions, ten fractions exceeded 3 mm shifts in any direction, including one in the left-right direction, four in the superior-inferior direction, and five in the anterior-posterior direction. With and without the additional kV-CBCT shifts, the average V 36.25 Gy of the prostate for the 22 fractions was 97.6 ± 2.6% with the kV x ray image alone, and was 98.1 ± 2.4% after applying the additional kV-CBCT shifts. The improvement was borderline statistical significance using Wilcoxon signed-rank test (P = 0.007). D 0.03 cc was 45.8 ± 6.3 Gy vs. 45.1 ± 4.9 Gy for the rectal wall; and 49.5 ± 8.6 Gy vs. 49.3 ± 7.9 Gy for the bladder before and after applying kV-CBCT shifts., Conclusions: Marker-based alignment alone is not sufficient. Additional adjustments are needed for some patients based kV-CBCT., (© 2018 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.)
Published: 2018
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24. Intra- and inter-fractional liver and lung tumor motions treated with SBRT under active breathing control.

Author: Lu L, Diaconu C, Djemil T, Videtic GM, Abdel-Wahab M, Yu N, Greskovich J Jr, Stephans KL, and Xia P
Subjects: Humans, Image Processing, Computer-Assisted methods, Liver Neoplasms diagnostic imaging, Lung Neoplasms diagnostic imaging, Patient Positioning, Radiotherapy Dosage, Retrospective Studies, Breath Holding, Cone-Beam Computed Tomography methods, Liver Neoplasms surgery, Lung Neoplasms surgery, Radiosurgery methods, Radiotherapy Planning, Computer-Assisted methods
Abstract: Purpose: To assess intra- and inter-fractional motions of liver and lung tumors using active breathing control (ABC)., Methods and Materials: Nineteen patients with liver cancer and 15 patients with lung cancer treated with stereotactic body radiotherapy (SBRT) were included in this retrospective study. All patients received a series of three CTs at simulation to test breath-hold reproducibility. The centroids of the whole livers and of the lung tumors from the three CTs were compared to assess intra-fraction variability. For 15 patients (8 liver, 7 lung), ABC-gated kilovoltage cone-beam CTs (kV-CBCTs) were acquired prior to each treatment, and the centroids of the whole livers and of the lung tumors were also compared to those in the planning CTs to assess inter-fraction variability., Results: Liver intra-fractional systematic/random errors were 0.75/0.39 mm, 1.36/0.97 mm, and 1.55/1.41 mm at medial-lateral (ML), anterior-posterior (AP), and superior-inferior (SI) directions, respectively. Lung intra-fractional systematic/random errors were 0.71/0.54 mm (ML), 1.45/1.10 mm (AP), and 3.95/1.93 mm (SI), respectively. Substantial intra-fraction motions (>3 mm) were observed in 26.3% of liver cancer patients and in 46.7% of lung cancer patients. For both liver and lung tumors, most inter-fractional systematic and random errors were larger than the corresponding intra-fractional errors. However, these inter-fractional errors were mostly corrected by the treatment team prior to each treatment based on kV CBCT-guided soft tissue alignment, thereby eliminating their effects on the treatment planning margins., Conclusions: Intra-fractional motion is the key to determine the planning margins since inter-fractional motion can be compensated based on daily gated soft tissue imaging guidance of CBCT. Patient-specific treatment planning margins instead of recipe-based margins were suggested, which can benefit mostly for the patients with small intra-fractional motions., (© 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.)
Published: 2018
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25. Pain flare after stereotactic radiosurgery for spine metastases.

Author: Balagamwala EH, Naik M, Reddy CA, Angelov L, Suh JH, Djemil T, Magnelli A, and Chao ST
Abstract: Purpose: Understanding of pain flare (PF) following spine stereotactic radiosurgery (sSRS) is lacking. This study sought to determine the incidence and risk factors associated with PF following single fraction sSRS., Materials/methods: An IRB-approved database was compiled to include patients who underwent sSRS. Patient and disease characteristics as well as treatment and dosimetric details were collected retrospectively. Pain relief post-sSRS was prospectively collected using the Brief Pain Inventory (BPI). These factors were correlated to the development of PF (defined as an increase in pain within 7 days of treatment which resolved with steroids). Survival was calculated using Kaplan-Meier analysis and logistic regression was utilized to evaluate the association between the clinical and treatment factors and occurrence of PF., Results: A total of 348 patients with 507 treatments were included. Median age and prescription dose were 59 years and 15 Gy (range: 7-18), respectively, and 62% of patients were male. Renal cell carcinoma (24%), lung cancer (14%), and breast cancer (11%) were the most common histologies, and 74% had epidural disease and 43% had thecal sac compression. The most common location of metastases was in the cervical/thoracic spine (59%), followed by lumbar spine (32%), and sacral spine (9%). Most common reason for treatment was pain (73%), followed by pain and neurological deficit (13%), asymptomatic disease (10%), and neurologic deficit only (3%). Median time to pain relief was 1.8 months. Median overall survival, time to radiographic failure, and time to pain progression were 13.6 months, 26.5 months, and 56.6 months, respectively. Only 14.4% of treatments resulted in the development of PF. Univariate analysis showed that higher Karnofsky performance score (KPS) (OR=1.03, p=0.03), female gender (OR=1.80, p=0.02), higher prescription dose (OR=1.30, p=0.008), and tumor location of cervical/thoracic spine vs lumbar spine (OR=1.81, p=0.047) were predictors for the development of PF. On multivariate analysis, higher consult KPS (OR=1.03, p=0.04), female gender (OR=1.93, p=0.01), higher prescription dose (OR=1.27, p=0.02), and tumor location of cervical/thoracic spine vs lumbar spine (OR=1.81, p=0.05) remained predictors of PF. No other dosimetric parameters were associated with the development of PF., Conclusion: PF is an infrequent complication of sSRS. Predictors for the development of PF include higher consult KPS, female gender, higher prescription dose, and cervical/thoracic tumor location. Dose to the spinal cord was not a predictor of PF. Since a minority (14.4%) of treatments result in PF, we do not routinely utilize prophylactic steroid treatment; however, prophylactic steroids may be considered in female patients with cervical/thoracic metastases receiving higher dose sSRS., Competing Interests: Authors’ disclosure of potential conflicts of interest Dr. Chao reports “honorarium” from Varian Medical Systems, outside the submitted work. Dr. Suh reports grants from Varian Medical Systems and “travel and lodging” from Elekta, outside the submitted work. Drs. Angelov, Balagamwala, Djemil, Magnelli, Naik, and Reddy have nothing to disclose.
Published: 2018

26. Dosimetric effect of multileaf collimator leaf width on volumetric modulated arc stereotactic radiotherapy for spine tumors.

Author: Amoush A, Long H, Subedi L, Qi P, Djemil T, and Xia P
Subjects: Humans, Radiotherapy Dosage, Reproducibility of Results, Retrospective Studies, Sensitivity and Specificity, Spinal Neoplasms diagnostic imaging, Treatment Outcome, Radiosurgery methods, Radiotherapy Planning, Computer-Assisted methods, Radiotherapy, Intensity-Modulated methods, Spinal Neoplasms radiotherapy
Abstract: This work aimed to study the dosimetric effect of multileaf collimator (MLC) leaf widths in treatment plans for patients receiving volumetric modulated arc therapy (VMAT) for spine stereotactic body radiation therapy (SBRT). Thirteen patients treated with spine SBRT were retrospectively selected for this study. The patients were treated following the protocol of the Radiation Therapy Oncology Group 0631 (RTOG 0631) for spine metastasis. The prescription dose was 16 Gy in 1 fraction to 90% of the target volume (V16 > 90%). The maximum spinal cord dose of 14 Gy and 10% of the spinal cord receiving < 10 Gy (V10) were the acceptable tolerance doses. For the purpose of this study, 2 dual-arc VMAT plans were created for each patient using 3 different MLC leaf widths: 2.5 mm, 4 mm, and 5 mm. The compliance with the RTOG 0631 protocol, conformity index (CI), dose gradient index (DGI), and number of monitor units (MUs) were compared. The average V16Gy of the targets was 91.8 ± 1.2%, 92.2 ± 2.1%, and 91.7 ± 2.3% for 2.5-mm, 4-mm, and 5-mm leaf widths, respectively (p = 0.78). Accordingly, the average CI was 1.45 ± 0.4, 1.47 ± 0.29, and 1.47 ± 0.31 (p = 0.98), respectively. The average DGI was 0.22 ± 0.04, 0.20 ± 0.06, and 0.22 ± 0.05, respectively (p = 0.77). The average maximum dose to the spinal cord was 12.45 ± 1.0 Gy, 12.80 ± 1.0 Gy, and 12.48 ± 1.1 (p = 0.62) and V10% of the spinal cord was 3.6 ± 2.1%, 5.6 ± 2.8%, and 5.5 ± 3.0% (p = 0.11) for 2.5-mm, 4-mm, and 5-mm leaf widths, respectively. Accordingly, the average number of MUs was 4341 ± 500 MU, 5019 ± 834 MU, and 4606 ± 691 MU, respectively (p = 0.053). The use of 2.5-mm, 4-mm, and 5-mm MLCs achieved similar VMAT plan quality as recommended by the RTOG 0631. The dosimetric parameters were also comparable for the 3 MLCs. In general, any of these leaf widths can be used for spine SBRT using VMAT., (Copyright © 2017 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.)
Published: 2017
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27. Single-Fraction Spine Stereotactic Body Radiation Therapy for the Treatment of Chordoma.

Author: Jung EW, Jung DL, Balagamwala EH, Angelov L, Suh JH, Djemil T, Magnelli A, and Chao ST
Subjects: Adolescent, Adult, Aged, Aged, 80 and over, Chordoma diagnostic imaging, Chordoma pathology, Disease-Free Survival, Female, Follow-Up Studies, Humans, Male, Middle Aged, Radiosurgery adverse effects, Spinal Neoplasms pathology, Spine diagnostic imaging, Spine radiation effects, Treatment Outcome, Chordoma radiotherapy, Radiosurgery methods, Spinal Neoplasms radiotherapy, Spine pathology
Abstract: Purpose: Chordoma is a radioresistant tumor that presents a therapeutic challenge with spine involvement, as high doses of radiation are needed for local control while limiting dose to the spinal cord. The purpose of this study is to determine the efficacy and safety of single-fraction spine stereotactic body radiation therapy for the treatment of spine chordoma., Methods: A retrospective review of our institutional database from 2006 to 2013 identified 8 patients (12 cases) with chordoma of the spine who were treated with spine stereotactic body radiation therapy. Surgical resection was performed in 7 of the 12 cases. The treatment volume was defined by the bony vertebral level of the tumor along with soft tissue extension appreciated on magnetic resonance imaging fusion. Medical records and imaging were assessed for pain relief and local control. Treatment toxicity was evaluated using Common Terminology Criteria for Adverse Events version 4.0., Results: Median age was 59 years (range, 17-91). Median target volume was 48 cm 3 (1-304), and median prescription dose was 16 Gy (11-16). Median conformality index was 1.44 (1.14-3.21), and homogeneity index was 1.12 (1.05-1.19). With a median follow-up time of 9.7 months (.5-84), local control was achieved in 75% of the cases treated. One patient developed limited grade 2 spinal cord myelopathy that resolved with steroids. There were no other treatment toxicities from spine stereotactic body radiation therapy., Conclusion: Single-fraction spine stereotactic body radiation therapy can be safely delivered to treat chordoma of the spine with the potential to improve pain symptoms. Although the early data are suggestive, long-term follow-up with more patients is necessary to determine the efficacy of spine stereotactic body radiation therapy in the treatment of chordoma of the spine.
Published: 2017
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28. Stereotactic Radiosurgery for the Treatment of Primary and Metastatic Spinal Sarcomas.

Author: Miller JA, Balagamwala EH, Angelov L, Suh JH, Djemil T, Magnelli A, Qi P, Zhuang T, Godley A, and Chao ST
Subjects: Adult, Aged, Disease-Free Survival, Female, Humans, Male, Middle Aged, Neoplasm Metastasis, Neoplasms, Second Primary pathology, Palliative Care, Retrospective Studies, Sarcoma pathology, Spinal Neoplasms pathology, Spine pathology, Treatment Outcome, Neoplasms, Second Primary radiotherapy, Radiosurgery methods, Sarcoma radiotherapy, Spinal Neoplasms radiotherapy
Abstract: Purpose: Despite advancements in local and systemic therapy, metastasis remains common in the natural history of sarcomas. Unfortunately, such metastases are the most significant source of morbidity and mortality in this heterogeneous disease. As a classically radioresistant histology, stereotactic radiosurgery has emerged to control spinal sarcomas and provide palliation. However, there is a lack of data regarding pain relief and relapse following stereotactic radiosurgery., Methods: We queried a retrospective institutional database of patients who underwent spine stereotactic radiosurgery for primary and metastatic sarcomas. The primary outcome was pain relief following stereotactic radiosurgery. Secondary outcomes included progression of pain, radiographic failure, and development of toxicities following treatment., Results: Forty treatment sites were eligible for inclusion; the median prescription dose was 16 Gy in a single fraction. Median time to radiographic failure was 14 months. At 6 and 12 months, radiographic control was 63% and 51%, respectively. Among patients presenting with pain, median time to pain relief was 1 month. Actuarial pain relief at 6 months was 82%. Median time to pain progression was 10 months; at 12 months, actuarial pain progression was 51%. Following multivariate analysis, presence of neurologic deficit at consult (hazard ratio: 2.48, P < .01) and presence of extraspinal bone metastases (hazard ratio: 2.83, P < .01) were associated with pain relief. Greater pain at consult (hazard ratio: 1.92, P < .01), prior radiotherapy (hazard ratio: 4.65, P = .02), and greater number of irradiated vertebral levels were associated with pain progression., Conclusions: Local treatment of spinal sarcomas has remained a challenge for decades, with poor rates of local control and limited pain relief following conventional radiotherapy. In this series, pain relief was achieved in 82% of treatments at 6 months, with half of patients experiencing pain progression by 12 months. Given minimal toxicity and suboptimal pain control at 12 months, dose escalation beyond 16 Gy is warranted.
Published: 2017
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29. Spine stereotactic radiosurgery for the treatment of multiple myeloma.

Author: Miller JA, Balagamwala EH, Chao ST, Emch T, Suh JH, Djemil T, and Angelov L
Subjects: Adult, Aged, Aged, 80 and over, Female, Humans, Incidence, Male, Middle Aged, Multiple Myeloma complications, Pain epidemiology, Retrospective Studies, Spinal Fractures etiology, Spinal Neoplasms complications, Treatment Outcome, Multiple Myeloma surgery, Radiosurgery methods, Spinal Fractures surgery, Spinal Neoplasms surgery
Abstract: OBJECTIVE The objective of this study was to define symptomatic and radiographic outcomes following spine stereotactic radiosurgery (SRS) for the treatment of multiple myeloma. METHODS All patients with pathological diagnoses of myeloma undergoing spine SRS at a single institution were included. Patients with less than 1 month of follow-up were excluded. The primary outcome measure was the cumulative incidence of pain relief after spine SRS, while secondary outcomes included the cumulative incidences of radiographic failure and vertebral fracture. Pain scores before and after treatment were prospectively collected using the Brief Pain Inventory (BPI), a validated questionnaire used to assess severity and impact of pain upon daily functions. RESULTS Fifty-six treatments (in 38 patients) were eligible for inclusion. Epidural disease was present in nearly all treatment sites (77%). Moreover, preexisting vertebral fracture (63%), thecal sac compression (55%), and neural foraminal involvement (48%) were common. Many treatment sites had undergone prior local therapy, including external beam radiation therapy (EBRT; 30%), surgery (23%), and kyphoplasty (21%). At the time of consultation for SRS, the worst, current, and average BPI pain scores at these treatment sites were 6, 4, and 4, respectively. The median prescription dose was 16 Gy in a single fraction. The median clinical follow-up duration after SRS was 26 months. The 6- and 12-month cumulative incidences of radiographic failure were 6% and 9%, respectively. Among painful treatment sites, 41% achieved pain relief adjusted for narcotic usage, with a median time to relief of 1.6 months. The 6- and 12-month cumulative incidences of adjusted pain progression were 13% and 15%, respectively. After SRS, 1-month and 3-month worst, current, and average BPI scores all significantly decreased (p < 0.01). Vertebral fracture occurred following 12 treatments (21%), with an 18% cumulative incidence of fracture at 6 and 12 months. Two patients (4%) developed pain flare following spine SRS. CONCLUSIONS This study reports the largest series of myeloma lesions treated with spine SRS. A rapid and durable symptomatic response was observed, with a median time to pain relief of 1.6 months. This response was durable among 85% of patients at 12 months following treatment, with 91% local control. The efficacy and minimal toxicity of spine SRS is likely related to the delivery of ablative and conformal radiation doses to the target. SRS should be considered with doses of 14-16 Gy in a single fraction for patients with multiple myeloma and limited spinal disease, myelosuppression requiring "marrow-sparing" radiation therapy, or recurrent disease after EBRT.
Published: 2017
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30. Stereotactic Body Radiotherapy for T3N0 Lung Cancer With Chest Wall Invasion.

Author: Berriochoa C, Videtic GM, Woody NM, Djemil T, Zhuang T, and Stephans KL
Subjects: Aged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung pathology, Female, Follow-Up Studies, Humans, Lung Neoplasms pathology, Male, Middle Aged, Neoplasm Invasiveness, Neoplasm Staging, Prognosis, Prospective Studies, Radiotherapy Dosage, Survival Rate, Thoracic Wall surgery, Carcinoma, Non-Small-Cell Lung surgery, Lung Neoplasms surgery, Radiosurgery methods, Thoracic Wall pathology
Abstract: Introduction: The role of stereotactic body radiotherapy (SBRT) for tumors involving the chest wall (CW) remains ill-defined. The Radiation Therapy Oncology Group 0236 trial allowed inclusion of T3N0 non-small-cell lung cancer (NSCLC) < 5 cm, although ultimately none were enrolled. No published data set investigating this population is available., Materials and Methods: We queried an institutional review board-approved prospective SBRT registry to identify patients with tumors involving the CW, defined as radiographic evidence of frank soft tissue invasion or bony destruction. All patients underwent SBRT to a median dose of 50 Gy in 5 fractions and were followed up for tumor control, pain response, and toxicity., Results: Of 820 NSCLC patients reviewed, 13 with CW involvement were identified. Of these 13 patients, 10 had primary T3N0 NSCLC and 3 had recurrent NSCLC. Their median age was 78 years, the Karnofsky performance status was 80, the Charlson score was 3, and the tumor diameter was 4.0 cm. The 1-year local, locoregional, and distant control rates were 89%, 62%, 80%, respectively. Of 9 patients with pretreatment tumor-related CW pain, 7 (78%) reported improvement after treatment. Regarding toxicity, 2 of 13 (15%) experienced new or worsening CW pain (both grade ≤ 2); 3 cases (23%) of grade 1-2 radiation pneumonitis developed. No patient exhibited late skin changes or fibrosis., Conclusion: SBRT for NSCLC involving the CW was well tolerated, with promising early rates of tumor control and no grade ≥ 3 toxicity. Tumor-related CW pain was relieved in most patients, and the treatment-related toxicity rates appeared acceptable. Further investigation in this subset of patients with NSCLC is warranted., (Copyright © 2016 Elsevier Inc. All rights reserved.)
Published: 2016
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31. Clinical and Quality of Life Implications of Vertebral Compression Fracture Following Spine Radiosurgery.

Author: Balagamwala EH, Miller JA, Angelov L, Suh JH, Mohammadi AM, Djemil T, Magnelli A, Soeder S, and Chao ST
Published: 2016
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32. Dose-Escalated Stereotactic Body Radiation Therapy for Patients With Intermediate- and High-Risk Prostate Cancer: Initial Dosimetry Analysis and Patient Outcomes.

Author: Kotecha R, Djemil T, Tendulkar RD, Reddy CA, Thousand RA, Vassil A, Stovsky M, Berglund RK, Klein EA, and Stephans KL
Subjects: Adult, Aged, Gastrointestinal Diseases diagnosis, Gastrointestinal Diseases prevention & control, Humans, Male, Middle Aged, Pilot Projects, Prostatic Neoplasms complications, Prostatic Neoplasms diagnosis, Radiation Injuries diagnosis, Radiation Injuries prevention & control, Risk Factors, Treatment Outcome, Dose Fractionation, Radiation, Gastrointestinal Diseases etiology, Prostatic Neoplasms radiotherapy, Radiation Injuries etiology, Radiosurgery adverse effects, Radiosurgery methods
Abstract: Purpose: To report the short-term clinical outcomes and acute and late treatment-related genitourinary (GU) and gastrointestinal (GI) toxicities in patients with intermediate- and high-risk prostate cancer treated with dose-escalated stereotactic body radiation therapy (SBRT)., Methods and Materials: Between 2011 and 2014, 24 patients with prostate cancer were treated with SBRT to the prostate gland and proximal seminal vesicles. A high-dose avoidance zone (HDAZ) was created by a 3-mm expansion around the rectum, urethra, and bladder. Patients were treated to a minimum dose of 36.25 Gy in 5 fractions, with a simultaneous dose escalation to a dose of 50 Gy to the target volume away from the HDAZ. Acute and late GU and GI toxicity outcomes were measured according to the National Cancer Institute Common Terminology Criteria for Adverse Events toxicity scale, version 4., Results: The median follow-up was 25 months (range, 18-45 months). Nine patients (38%) experienced an acute grade 2 GU toxicity, which was medically managed, and no patients experienced an acute grade 2 GI toxicity. Two patients (8%) experienced late grade 2 GU toxicity, and 2 patients (8%) experienced late grade 2 GI toxicity. No acute or late grade ≥3 GU or GI toxicities were observed. The 24-month prostate-specific antigen relapse-free survival outcome for all patients was 95.8% (95% confidence interval 75.6%-99.4%), and both biochemical failures occurred in patients with high-risk disease. All patients are currently alive at the time of this analysis and continue to be followed., Conclusions: A heterogeneous prostate SBRT planning technique with differential treatment volumes (low dose: 36.25 Gy; and high dose: 50 Gy) with an HDAZ provides a safe method of dose escalation. Favorable rates of biochemical control and acceptably low rates of acute and long-term GU and GI toxicity can be achieved in patients with intermediate- and high-risk prostate cancer treated with SBRT., (Copyright © 2016 Elsevier Inc. All rights reserved.)
Published: 2016
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33. Impact of small MU/segment and dose rate on delivery accuracy of volumetric-modulated arc therapy (VMAT).

Author: Huang L, Zhuang T, Mastroianni A, Djemil T, Cui T, and Xia P
Subjects: Humans, Particle Accelerators, Radiometry, Radiotherapy Dosage, Organs at Risk radiation effects, Phantoms, Imaging, Radiotherapy Planning, Computer-Assisted methods, Radiotherapy, Intensity-Modulated instrumentation, Radiotherapy, Intensity-Modulated methods
Abstract: Volumetric-modulated arc therapy (VMAT) plans may require more control points (or segments) than some of fixed-beam IMRT plans that are created with a limited number of segments. Increasing number of control points in a VMAT plan for a given prescription dose could create a large portion of the total number of segments with small number monitor units (MUs) per segment. The purpose of this study is to investigate the impact of the small number MU/segment on the delivery accuracy of VMAT delivered with various dose rates. Ten patient datasets were planned for hippocampus sparing for whole brain irradiation. For each dataset, two VMAT plans were created with maximum dose rates of 600 MU/min (the maximum field size of 21 × 40 cm2) and 1000 MU/min (the maximum field size of 15 × 15 cm2) for a daily dose of 3 Gy. Without reoptimization, the daily dose of these plans was purposely reduced to 1.5 Gy and 1.0 Gy while keeping the same total dose. Using the two dose rates and three different daily doses, six VMAT plans for each dataset were delivered to a physical phantom to investigate how the changes of dose rate and daily doses impact on delivery accuracy. Using the gamma index, we directly compared the delivered planar dose profiles with the reduced daily doses (1.5 Gy and 1.0 Gy) to the delivered planar dose at 3 Gy daily dose, delivered at dose rate of 600 MU/min and 1000 MU/min, respectively. The average numbers of segments with MU/segment ≤ 1 were 35 ± 8, 87 ± 6 for VMAT-600 1.5 Gy, VMAT-600 1 Gy plans, and 30 ± 7 and 42 ± 6 for VMAT-1000 1.5 Gy and VMAT-1000 1 Gy plans, respectively. When delivered at 600 MU/min dose rate, the average gamma index passing rates (1%/1 mm criteria) of comparing delivered 1.5 Gy VMAT planar dose profiles to 3.0 Gy VMAT delivered planar dose profiles was 98.28% ± 1.66%, and the average gamma index passing rate of comparing delivered 1.0 Gy VMAT planar dose to 3.0 Gy VMAT delivered planar dose was 83.75% ± 4.86%. If using 2%/2mm and 3%/3 mm criteria, the gamma index passing rates were greater than 97% for both 1.5 Gy VMAT and 1.0 Gy VMAT delivered planar doses. At 1000MU/min dose rate, the average gamma index passing rates were 96.59% ± 2.70% for 1.5 Gy VMAT planar dose profiles and 79.37% ± 9.96% for 1.0 Gy VMAT planar dose profiles when compared to the 3.0 Gy VMAT planar delivered dose profile. When using 2%/2 mm and 3%/3 mm criteria, the gamma index passing rates were greater than 93% for both 1.5 Gy VMAT and 1.0 Gy VMAT planar delivered dose. Under a stricter gamma index criterion (1%/1 mm), significant differences in delivered planar dose profiles at different daily doses were detected, indicating that the known communication delay between the MU console and MLC console may affect VMAT delivery accuracy.
Published: 2016
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34. Quantitative Evaluation of Local Control and Wound Healing Following Surgery and Stereotactic Spine Radiosurgery for Spine Tumors.

Author: Harel R, Emch T, Chao S, Elson P, Krishnaney A, Djemil T, Suh J, and Angelov L
Subjects: Adolescent, Adult, Aged, Aged, 80 and over, Child, Combined Modality Therapy, Female, Humans, Magnetic Resonance Imaging, Male, Medical Records, Middle Aged, Neurosurgical Procedures adverse effects, Radiotherapy Dosage, Response Evaluation Criteria in Solid Tumors, Retrospective Studies, Treatment Outcome, World Health Organization, Decompression, Surgical methods, Radiosurgery adverse effects, Spinal Fusion instrumentation, Spinal Fusion methods, Spinal Neoplasms pathology, Spinal Neoplasms surgery, Tumor Burden, Wound Healing
Abstract: Objective: The present study evaluated the optimal measuring criteria to assess spinal tumor response to surgery followed by stereotactic spine radiosurgery (SRS) and reports the local control and wound complication rates following combined multimodality treatment., Methods and Materials: Prospectively collected patient information was retrospectively reviewed to identify patients treated with spine surgery followed by SRS. Tumor sizes and volumetric assessment were formally measured. Local control status was defined according to World Health Organization (WHO, bidimensional), RECIST (unidimensional), or volumetric size change. Statistical comparative assessments of tumor measurements were performed., Results: Twenty-two patients were eligible for evaluation after having undergone surgery followed by single-fraction SRS within a 2-month period. Seventeen had follow-up magnetic resonance imaging (MRI) with a mean patient follow-up of 12.59 months (range 3-36 months). None developed wound complication after radiation therapy (95% lower confidence bound 13%). Two patients had clinical recurrence while 15 of 17 achieved local control (88.3%). A test of marginal homogeneity for RECIST versus WHO was not statistically significant, P = 1.0 suggesting similar response classifications with both systems. Spearman correlations among 1) volumetric assessment, 2) bidimensional size, and 3) unidimensional size were significant for all groups (P < 0.05)., Conclusion: High local control rates can be achieved with surgery followed by SRS. Further, adjuvant SRS following spine tumor surgery delivers less radiation to the wound than conventional radiation and thus potentially reduces wound complications. Unidimensional, bidimensional, and volumetric tumor assessments demonstrate similar results. Hence the use of the simpler RECIST criteria is suitable and appropriate for evaluating the response to treatment after spine radiosurgery., (Copyright © 2016 Elsevier Inc. All rights reserved.)
Published: 2016
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35. [Composition of 359 kidney stones from the East region of Algeria].

Author: Bouslama S, Boutefnouchet A, Hannache B, Djemil T, Kadi A, Dahdouh A, Saka S, and Daudon M
Subjects: Adult, Aged, Algeria epidemiology, Antioxidants analysis, Apatites analysis, Female, Hemostatics analysis, Hospitals statistics & numerical data, Humans, Magnesium Compounds analysis, Male, Middle Aged, Phosphates analysis, Prevalence, Retrospective Studies, Risk Factors, Sex Distribution, Spectroscopy, Fourier Transform Infrared methods, Struvite, Uric Acid analysis, Calcium Oxalate analysis, Kidney Calculi chemistry, Kidney Calculi epidemiology
Abstract: Purpose: Determine stones composition of the upper urinary tract in the eastern region of Algeria., Methods: Our study focuses on a set of 359 stones of the upper urinary tract collected between January 2007 and December 2012 at hospitals in the eastern region of Algeria and analyzed by Fourier transform infrared spectroscopy., Results: The male/female ratio was only 1.32. Calcium oxalate prevailed in 68.5% of stones and 49.3% of nuclei, mainly as whewellite (51.8% of stones and 37.9% of nuclei vs 16.7% and 11.4% respectively for weddellite). Carbapatite prevailed in 15% of stones and 29.8% of nuclei. The struvite, identified in 11.1% of calculi, prevailed in 3.9% of stones and 3.1% of nuclei. Among purines, uric acid prevailed with frequencies quite close to 8.9% and 7% respectively in the stone and in the nucleus while the ammonium urate prevailed in only 0.3% of stones and 3.3% of nuclei. The cystine frequency was 3.6% in both stone and nucleus. The frequency of stone with umbilication was 26.2%. Whewellite was the main component of umbilicated stones with Randall's plaque., Conclusion: Our results suggest that stones of the urinary tract in the Algerian east region resemble those observed in industrialized countries. Some features such as stones location, the whewellite prevalence, the frequencies of main components in both the stone and the nucleus as well as the formation of stones on renal papilla confirm this trend., Level of Evidence: 4., (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)
Published: 2016
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36. Dose differences in intensity-modulated radiotherapy plans calculated with pencil beam and Monte Carlo for lung SBRT.

Author: Liu H, Zhuang T, Stephans K, Videtic G, Raithel S, Djemil T, and Xia P
Subjects: Algorithms, Humans, Monte Carlo Method, Organs at Risk, Radiosurgery statistics & numerical data, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted statistics & numerical data, Radiotherapy, Intensity-Modulated statistics & numerical data, Retrospective Studies, Carcinoma, Non-Small-Cell Lung radiotherapy, Carcinoma, Non-Small-Cell Lung surgery, Lung Neoplasms radiotherapy, Lung Neoplasms surgery, Radiosurgery methods, Radiotherapy Planning, Computer-Assisted methods, Radiotherapy, Intensity-Modulated methods
Abstract: For patients with medically inoperable early-stage non-small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy, early treatment plans were based on a simpler dose calculation algorithm, the pencil beam (PB) calculation. Because these patients had the longest treatment follow-up, identifying dose differences between the PB calculated dose and Monte Carlo calculated dose is clinically important for understanding of treatment outcomes. Previous studies found significant dose differences between the PB dose calculation and more accurate dose calculation algorithms, such as convolution-based or Monte Carlo (MC), mostly for three-dimensional conformal radiotherapy (3D CRT) plans. The aim of this study is to investigate whether these observed dose differences also exist for intensity-modulated radiotherapy (IMRT) plans for both centrally and peripherally located tumors. Seventy patients (35 central and 35 peripheral) were retrospectively selected for this study. The clinical IMRT plans that were initially calculated with the PB algorithm were recalculated with the MC algorithm. Among these paired plans, dosimetric parameters were compared for the targets and critical organs. When compared to MC calculation, PB calculation overestimated doses to the planning target volumes (PTVs) of central and peripheral tumors with different magnitudes. The doses to 95% of the central and peripheral PTVs were overestimated by 9.7% ± 5.6% and 12.0% ± 7.3%, respectively. This dose overestimation did not affect doses to the critical organs, such as the spinal cord and lung. In conclusion, for NSCLC treated with IMRT, dose differences between the PB and MC calculations were different from that of 3D CRT. No significant dose differences in critical organs were observed between the two calculations.
Published: 2015
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37. Dosimetric impact of orthopedic metal artifact reduction (O-MAR) on Spine SBRT patients.

Author: Shen ZL, Xia P, Klahr P, and Djemil T
Subjects: Humans, Phantoms, Imaging, Prostheses and Implants, Radiographic Image Enhancement methods, Radiographic Image Interpretation, Computer-Assisted, Radiography, Abdominal, Radiotherapy Dosage, Radiotherapy, Image-Guided methods, Retrospective Studies, Algorithms, Artifacts, Orthopedic Fixation Devices, Radiosurgery methods, Spinal Neoplasms surgery, Titanium chemistry, Tomography, X-Ray Computed
Abstract: The dosimetric impact of orthopedic metal artifact reduction (O-MAR) on spine SBRT patients has not been comprehensively studied, particularly with spinal prostheses in high-dose gradient regions. Using both phantom and patient datasets, we investigated dosimetric effects of O-MAR in combination of various metal locations and dose calculation algorithms. A physical phantom, with and without a titanium insert, was scanned. A clinical patient plan was applied to the artifact-free reference, non-O-MAR, and O-MAR phantom images with the titanium located either inside or outside of the tumor. Subsequently, five clinical patient plans were calculated with pencil beam and Monte Carlo (iPlan) on non-O-MAR and O-MAR patient images using an extended CT-density table. The dose differences for phantom plans and patient plans were analyzed using dose distributions, dose-volume histograms (DVHs), gamma index, and selected dosimetric endpoints. From both phantom plans and patient plans, O-MAR did not affect dose distributions and DVHs while minimizing metal artifacts. Among patient plans, we found that, when the same dose calculation method was used, the difference in the dosimetric endpoints between non-O-MAR and O-MAR datasets were small. In conclusion, for spine SBRT patients with spinal prostheses, O-MAR image reconstruction does not affect dose calculation accuracy while minimizing metal artifacts. Therefore, O-MAR images can be safely used for clinical spine SBRT treatment planning.
Published: 2015
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38. Stereotactic Body Radiation Therapy for Non-Small Cell Lung Cancer Tumors Greater Than 5 cm: Safety and Efficacy.

Author: Woody NM, Stephans KL, Marwaha G, Djemil T, and Videtic GM
Subjects: Adenocarcinoma diagnostic imaging, Adenocarcinoma mortality, Adenocarcinoma pathology, Adenocarcinoma secondary, Adenocarcinoma surgery, Aged, Aged, 80 and over, Body Mass Index, Carcinoma, Non-Small-Cell Lung diagnostic imaging, Carcinoma, Non-Small-Cell Lung mortality, Carcinoma, Non-Small-Cell Lung secondary, Carcinoma, Squamous Cell diagnostic imaging, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell secondary, Carcinoma, Squamous Cell surgery, Disease-Free Survival, Dose Fractionation, Radiation, Female, Humans, Karnofsky Performance Status, Lung Neoplasms diagnostic imaging, Lung Neoplasms mortality, Male, Middle Aged, Positron-Emission Tomography methods, Proportional Hazards Models, Radiosurgery methods, Radiosurgery mortality, Retrospective Studies, Safety, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Non-Small-Cell Lung surgery, Lung Neoplasms pathology, Lung Neoplasms surgery, Radiosurgery adverse effects, Tumor Burden
Abstract: Purpose: The purpose of this study was to determine outcomes of patients with node-negative medically inoperable non-small cell lung cancer (NSCLC) whose primary tumors exceeded 5 cm and were treated with stereotactic body radiation therapy (SBRT)., Methods and Materials: We surveyed our institutional prospective lung SBRT registry to identify treated patients with tumors >5 cm. Treatment outcomes for local control (LC), locoregional control (LRC), disease-free survival (DFS), and overall survival (OS) were assessed by Kaplan-Meier estimates. Toxicities were graded according to Common Terminology Criteria for Adverse Events version 4. Mean pretreatment pulmonary function test values were compared to mean posttreatment values., Results: From December 2003 to July 2014, 40 patients met study criteria. Median follow-up was 10.8 months (range: 0.4-70.3 months). Median age was 76 years (range: 56-90 years), median body mass index was 24.3 (range: 17.7-37.2), median Karnofsky performance score was 80 (range: 60-90), and median Charlson comorbidity index score was 2 (range: 0-5). Median forced expiratory volume in 1 second (FEV1) was 1.41 L (range: 0.47-3.67 L), and median diffusion capacity (DLCO) was 47% of predicted (range: 29%-80%). All patients were staged by fluorodeoxyglucose-positron emission tomography/computed tomography staging, and 47.5% underwent mediastinal staging by endobronchial ultrasonography. Median tumor size was 5.6 cm (range: 5.1-10 cm), median SBRT dose was 50 Gy (range: 30-60 Gy) in 5 fractions (range: 3-10 fractions). Eighteen-month LC, LRC, DFS, and OS rates were 91.2%, 64.4%, 34.6%, and 59.7%, respectively. Distant failure was the predominant pattern of failure (32.5%). Three patients (7.5%) experienced grade 3 or higher toxicity. Mean posttreatment FEV1 was not significantly reduced (P=.51), but a statistically significant absolute 6.5% (P=.03) reduction in DLCO was observed., Conclusions: Lung SBRT for medically inoperable node-negative NSCLC with primary tumors larger than 5 cm is safe and provides excellent local control with limited toxicity. The predominant pattern of failure in this population was distant failure., (Copyright © 2015 Elsevier Inc. All rights reserved.)
Published: 2015
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39. Stereotactic body radiotherapy for a large arteriovenous malformation of the head and neck.

Author: Koyfman SA, Shukla ME, Bricker A, Djemil T, Wood B, Masaryk T, and Suh JH
Subjects: Adult, Arteriovenous Malformations diagnostic imaging, Female, Humans, Radiography, Tongue diagnostic imaging, Arteriovenous Malformations surgery, Radiosurgery, Tongue blood supply, Tongue surgery
Abstract: Large arteriovenous malformations (AVMs) of the head and neck present a treatment challenge. A 38-year-old woman presented with a large intraoral bleed from longstanding AVMs of the left infratemporal fossa and the right tongue, despite 10 prior surgeries and embolizations. She was treated with stereotactic body radiotherapy with a dose of 24 Gy in three weekly fractions. Four years later, she has had dramatic shrinkage of her AVM, no recurrent bleeding episodes, no further treatment required, and no significant late effects. Level of evidence: NA., (© 2014 The American Laryngological, Rhinological and Otological Society, Inc.)
Published: 2015
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40. Salvage stereotactic body radiation therapy (SBRT) for local failure after primary lung SBRT.

Author: Hearn JW, Videtic GM, Djemil T, and Stephans KL
Subjects: Adenocarcinoma pathology, Adenocarcinoma surgery, Aged, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell surgery, Female, Humans, Karnofsky Performance Status, Lung Neoplasms pathology, Male, Middle Aged, Neoplasm Recurrence, Local pathology, Radiation Dosage, Radiosurgery adverse effects, Radiotherapy, Image-Guided instrumentation, Salvage Therapy adverse effects, Treatment Failure, Tumor Burden, Carcinoma, Non-Small-Cell Lung surgery, Lung Neoplasms surgery, Neoplasm Recurrence, Local surgery, Radiosurgery methods, Salvage Therapy methods
Abstract: Purpose: Local failure after definitive stereotactic body radiation therapy (SBRT) for early-stage non-small cell lung cancer (NSCLC) is uncommon. We report the safety and efficacy of SBRT for salvage of local failure after previous SBRT with a biologically effective dose (BED) of ≥ 100 Gy10., Methods and Materials: Using an institutional review board-approved lung SBRT registry, we identified all patients initially treated for early-stage NSCLC between August 2004 and January 2012 who received salvage SBRT for isolated local failure. Failure was defined radiographically and confirmed histologically unless contraindicated. All patients were treated on a Novalis/BrainLAB system using ExacTrac for image guidance, and received a BED of ≥ 100 Gy10 for each SBRT course. Tumor motion control involved a Bodyfix vacuum system for immobilization along with abdominal compression., Results: Of 436 patients treated from August 2004 through January 2012, we identified 22 patients with isolated local failure, 10 of whom received SBRT for salvage. The median length of follow-up was 13.8 months from salvage SBRT (range 5.3-43.5 months). Median tumor size was 3.4 cm (range 1.7-4.8 cm). Two of the 10 lesions were "central" by proximity to the mediastinum, but were outside the zone of the proximal bronchial tree. Since completing salvage, 3 patients are alive and without evidence of disease. A fourth patient died of medical comorbidities without recurrence 13.0 months after salvage SBRT. Two patients developed distant disease only. Four patients had local failure. Toxicity included grade 1-2 fatigue (3 patients) and grade 1-2 chest wall pain (5 patients). There was no grade 3-5 toxicity., Conclusions: Repeat SBRT with a BED of ≥ 100 Gy10 after local failure in patients with early-stage medically inoperable NSCLC was well tolerated in this series and may represent a viable salvage strategy in select patients with peripheral tumors ≤ 5 cm., (Copyright © 2014 Elsevier Inc. All rights reserved.)
Published: 2014
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41. 30 Gy or 34 Gy? Comparing 2 single-fraction SBRT dose schedules for stage I medically inoperable non-small cell lung cancer.

Author: Videtic GM, Stephans KL, Woody NM, Reddy CA, Zhuang T, Magnelli A, and Djemil T
Subjects: Aged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung mortality, Carcinoma, Non-Small-Cell Lung pathology, Cohort Studies, Female, Humans, Lung Neoplasms mortality, Lung Neoplasms pathology, Male, Middle Aged, Neoplasm Staging, Radiosurgery adverse effects, Radiosurgery mortality, Radiotherapy Dosage, Retrospective Studies, Survival Rate, Treatment Outcome, Carcinoma, Non-Small-Cell Lung surgery, Lung Neoplasms surgery, Radiosurgery methods
Abstract: Purpose: To review outcomes of 2 single-fraction lung stereotactic body radiation therapy (SBRT) schedules used for medically inoperable early stage lung cancer., Methods and Materials: Patients in our institution have been treated on and off protocols using single-fraction SBRT (30 Gy and 34 Gy, respectively). All patients had node-negative lung cancer measuring ≤5 cm and lying ≥2 cm beyond the trachea-bronchial tree and were treated on a Novalis/BrainLAB system with the ExactTrac positioning system for daily image guidance., Results: For the interval from 2009 to 2012, 80 patients with 82 lesions were treated with single-fraction lung SBRT. Fifty-five patients (69%) and 25 patients (31%) received 30 Gy and 34 Gy, respectively. In a comparison of 30 Gy and 34 Gy cohorts, patient and tumor characteristics were balanced and median follow-up in months was 18.7 and 17.8, respectively. The average heterogeneity-corrected mean doses to the target were 33.75 Gy and 37.94 Gy for the 30-Gy and 34-Gy prescriptions, respectively. Comparing 30-Gy and 34-Gy cohorts, 92.7% and 84.0% of patients, respectively, experienced no toxicity (P was not significant), and had neither grade 3 nor higher toxicities. For the 30-Gy and 34-Gy patients, rates of 1-year local failure, overall survival, and lung cancer-specific mortality were 2.0% versus 13.8%, 75.0% versus 64.0%, and 2. 1% versus 16.0%, respectively (P values for differences were not significant)., Conclusions: This is the largest single-fraction lung SBRT series yet reported. and it confirms the safety, efficacy, and minimal toxicity of this schedule for inoperable early stage lung cancer., (Copyright © 2014 Elsevier Inc. All rights reserved.)
Published: 2014
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42. Esophageal dose tolerance to hypofractionated stereotactic body radiation therapy: risk factors for late toxicity.

Author: Stephans KL, Djemil T, Diaconu C, Reddy CA, Xia P, Woody NM, Greskovich J, Makkar V, and Videtic GM
Subjects: Adult, Aged, Aged, 80 and over, Carcinoma, Hepatocellular drug therapy, Carcinoma, Hepatocellular pathology, Carcinoma, Hepatocellular surgery, Carcinoma, Non-Small-Cell Lung drug therapy, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Non-Small-Cell Lung surgery, Dose Fractionation, Radiation, Esophagus pathology, Female, Humans, Liver Neoplasms drug therapy, Liver Neoplasms pathology, Lung Neoplasms drug therapy, Lung Neoplasms pathology, Male, Middle Aged, Organs at Risk radiation effects, Radiation Injuries complications, Registries, Retrospective Studies, Risk Factors, Vascular Endothelial Growth Factor A antagonists & inhibitors, Esophageal Fistula etiology, Esophagus radiation effects, Liver Neoplasms surgery, Lung Neoplasms surgery, Radiation Injuries pathology, Radiation Tolerance, Radiosurgery adverse effects
Abstract: Purpose: To identify factors associated with grade ≥3 treatment related late esophageal toxicity after lung or liver stereotactic body radiation therapy (SBRT)., Methods and Materials: This was a retrospective review of 52 patients with a planning target volume within 2 cm of the esophagus from a prospective registry of 607 lung and liver SBRT patients treated between 2005 and 2011. Patients were treated using a risk-adapted dose regimen to a median dose of 50 Gy in 5 fractions (range, 37.5-60 Gy in 3-10 fractions). Normal structures were contoured using Radiation Therapy Oncology Group (RTOG) defined criteria., Results: The median esophageal point dose and 1-cc dose were 32.3 Gy (range, 8.9-55.4 Gy) and 24.0 Gy (range, 7.8-50.9 Gy), respectively. Two patients had an esophageal fistula at a median of 8.4 months after SBRT, with maximum esophageal point doses of 51.5 and 52 Gy, and 1-cc doses of 48.1 and 50 Gy, respectively. These point and 1-cc doses were exceeded by 9 and 2 patients, respectively, without a fistula. The risk of a fistula for point doses exceeding 40, 45, and 50 Gy was 9.5% (n=2/21), 10.5% (n=2/19), and 12.5% (n=2/16), respectively. The risk of fistula for 1-cc doses exceeding 40, 45, and 50 Gy was 25% (n=2/9), 50% (n=2/4), and 50% (n=2/4), respectively. Eighteen patients received systemic therapy after SBRT (11 systemic chemotherapy, and 6 biologic agents, and 1 both). Both patients with fistulas had received adjuvant anti-angiogenic (vascular endothelial growth factor) agents within 2 months of completing SBRT. No patient had a fistula in the absence of adjuvant VEGF-modulating agents., Conclusions: Esophageal fistula is a rare complication of SBRT. In this series, fistula was seen with esophageal point doses exceeding 51 Gy and 1-cc doses greater than 48 Gy. Notably, however, fistula was seen only in those patients who also received adjuvant VEGF-modulating agents after SBRT. The potential interaction of dose and adjuvant therapy should be considered when delivering SBRT near the esophagus., (Copyright © 2014 Elsevier Inc. All rights reserved.)
Published: 2014
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43. Synchronous non small cell lung cancer nodules treated with stereotactic body radiation therapy (SBRT).

Author: Kumar AMS, Woody NM, Djemil T, Videtic GMM, and Stephans KL
Abstract: Background and Purpose: We compare our institutional outcomes of synchronous primary (SP) lung lesion patients with non-SP patients.Materials and Methods: From an IRB approved prospective registry of 445 NSCLC patients treated with SBRT (8/2005 8/2012), 26 (5.8%) had SPs by biopsy or PET/CT. SBRT was delivered on a Novalis/BrainLAB platform with daily Exactrac set-up., Results: There were no significant differences comparing SP vs non-SP groups for age, Charlson score, smoking pack years, and PET SUV (p=ns). 18 (69%) SP patients had at least one lesion biopsied. Ipsilateral and bilateral SPs were seen in 10 (38.4%) and 16 (61.6%) respectively. 77% received 50 Gy / 5 fx. SP vs non-SP median follow up was 12 (range 1.5-49.8) vs 15.2 months. Median survival for SP vs non-SP groups was 20.7 vs 28.4 months (p=0.3). In SP vs non-SP groups, local failure was 4% vs 7.6% (p=ns) and nodal/distant failure was 23% vs 24.6% (p=ns). Patients with ipsilateral and bilateral SPs had a 50% vs 14% distant failure respectively (p=0.037)., Conclusions: After SBRT, there were no differences in survival and patterns of failure for SP vs non-SP patients. Ipsilateral SPs had significantly worse distant failure compared to bilateral SPs.
Published: 2014

44. Stereotactic body radiation therapy-based treatment model for stage I medically inoperable small cell lung cancer.

Author: Videtic GM, Stephans KL, Woody NM, Pennell NA, Shapiro M, Reddy CA, and Djemil T
Abstract: Purpose: To report on medically inoperable stage I small cell lung cancer (SCLC) patients for whom stereotactic body radiation therapy (SBRT) was employed to manage the primary tumor., Methods and Materials: Review of our institutional review board approved SBRT registry revealed 6 cases of stage I SCLC out of 430 patients over a 6-year interval (2004-2010). All patients had biopsy proven disease and deemed medically inoperable by a thoracic surgeon. Our institutional approach was to treat with a combination of SBRT, platinum-etoposide chemotherapy (CHT) and prophylactic cranial irradiation (PCI). SBRT was delivered using a Novalis/BrainLAB platform and ExacTrac (BrainLab, Westchester, IL) for image guidance., Results: Patient characteristics included a median Karnofsky performance scale of 80, a median age of 68 years, 4 females, and 1 patient still smoking at presentation. Impaired pulmonary function caused inoperability in 50% of cases. Tumor characteristics included median tumor size of 2.6 cm and median positron emission tomography-standard uptake valuemax of 9. The SBRT was 60 Gy/3 fractions (3 patients), 50 Gy/5 fractions (2 patients), 30 Gy/1 fraction (1 patient). Median follow-up was 11.9 months. There was no grade 3 or higher, and 1 grade 2, toxicity. Three patients were alive at analysis and 3 patients had died of non-cancer causes. At 1 year, local control was 100%, there was no regional nodal failure, and 1 patient had distant failure (liver). Overall and disease-free survivals at 1 year were 63% and 75%, respectively., Conclusions: Employing SBRT for stage I medically inoperable SCLC is rational, with excellent local control and encouraging disease-specific survival. The absence of regional nodal failure supports positron emission tomography for mediastinal staging. Platinum-based CHT may be feasible in vulnerable populations., (Copyright © 2013 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.)
Published: 2013
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45. Dose calculation differences between Monte Carlo and pencil beam depend on the tumor locations and volumes for lung stereotactic body radiation therapy.

Author: Zhuang T, Djemil T, Qi P, Magnelli A, Stephans K, Videtic G, and Xia P
Subjects: Humans, Reproducibility of Results, Sensitivity and Specificity, Treatment Outcome, Tumor Burden, Carcinoma, Non-Small-Cell Lung surgery, Lung Neoplasms surgery, Monte Carlo Method, Radiosurgery methods, Radiotherapy Planning, Computer-Assisted methods, Surgery, Computer-Assisted methods
Abstract: Stereotactic body radiation therapy (SBRT) has been increasingly used as an efficacious treatment modality for early-stage non-small cell lung cancer. The accuracy of dose calculations is compromised due to the presence of inhomogeneity. For the purpose of a consistent prescription, radiation doses were calculated without heterogeneity correction in several RTOG trials. For patients participating in these trials, recalculations of the planned doses with more accurate dose methods could provide better correlations between the treatment outcomes and the planned doses. Using a Monte Carlo (MC) dose calculation algorithm as a gold standard, we compared the recalculated doses with the MC algorithm to the original pencil beam (PB) calculations for our institutional clinical lung SBRT plans. The focus of this comparison is to investigate the volume and location dependence on the differences between the two dose calculations. Thirty-one clinical plans that followed RTOG and other protocol guidelines were retrospectively investigated in this study. Dosimetric parameters, such as D1, D95, and D99 for the PTV and D1 for organs at risk, were compared between two calculations. Correlations of mean lung dose and V20 of lungs between two calculations were investigated. Significant dependence on tumor size and location was observed from the comparisons between the two dose calculation methods. When comparing the PB calculations without heterogeneity correction to the MC calculations with heterogeneity correction, we found that in terms of D95 of PTV: (1) the two calculations resulted in similar D95 for edge tumors with volumes greater than 25.1 cc; (2) an average overestimation of 5% in PB calculations for edge tumors with volumes less than 25.1 cc; and (3) an average overestimation of 9% or underestimation of 3% in PB calculations for island tumors with volumes smaller or greater than 22.6 cc, respectively. With heterogeneity correction, the PB calculations resulted in an average reduction of 23.8% and 15.3% in the D95 for the PTV for island and edge lesions, respectively, when compared to the MC calculations. For organs at risks, very small differences were found among all the comparisons. Excellent correlations for mean dose and V20 of lungs were observed between the two calculations. This study demonstrated that using a single scaling factor may be overly simplified when accounting for the effects of heterogeneity correction. Accurate dose calculations, such as the Monte Carlo algorithms, are highly recommended to understand dose responses in lung SBRT.
Published: 2013
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46. Single-fraction stereotactic body radiotherapy for spinal metastases from renal cell carcinoma.

Author: Balagamwala EH, Angelov L, Koyfman SA, Suh JH, Reddy CA, Djemil T, Hunter GK, Xia P, and Chao ST
Subjects: Adult, Aged, Aged, 80 and over, Carcinoma, Renal Cell secondary, Disease Progression, Female, Follow-Up Studies, Humans, Kidney Neoplasms pathology, Male, Middle Aged, Retrospective Studies, Spinal Neoplasms secondary, Treatment Outcome, Carcinoma, Renal Cell surgery, Kidney Neoplasms surgery, Radiosurgery, Spinal Neoplasms surgery
Abstract: Object: Stereotactic body radiotherapy (SBRT) has emerged as an important treatment option for spinal metastases from renal cell carcinoma (RCC) as a means to overcome RCC's inherent radioresistance. The authors reviewed the outcomes of SBRT for the treatment of RCC metastases to the spine at their institution, and they identified factors associated with treatment failure., Methods: Fifty-seven patients (88 treatment sites) with RCC metastases to the spine received single-fraction SBRT. Pain relief was based on the Brief Pain Inventory and was adjusted for narcotic use according to the Radiation Therapy Oncology Group protocol 0631. Toxicity was scored according to Common Toxicity Criteria for Adverse Events version 4.0. Radiographic failure was defined as infield or adjacent (within 1 vertebral body [VB]) failure on follow-up MRI. Multivariate analyses were performed to correlate outcomes with the following variables: epidural, paraspinal, single-level, or multilevel disease (2-5 sites); neural foramen involvement; and VB fracture prior to SBRT. Kaplan-Meier analysis and Cox proportional hazards modeling were used for statistical analysis., Results: The median follow-up and survival periods were 5.4 months (range 0.3-38 months) and 8.3 months (range 1.5-38 months), respectively. The median time to radiographic failure and unadjusted pain progression were 26.5 and 26.0 months, respectively. The median time to pain relief (from date of simulation) and duration of pain relief (from date of treatment) were 0.9 months (range 0.1-4.4 months) and 5.4 months (range 0.1-37.4 months), respectively. Multivariate analyses demonstrated that multilevel disease (hazard ratio [HR] 3.5, p = 0.02) and neural foramen involvement (HR 3.4, p = 0.02) were correlated with radiographic failure; multilevel disease (HR 2.3, p = 0.056) and VB fracture (HR 2.4, p = 0.046) were correlated with unadjusted pain progression. One patient experienced Grade 3 nausea and vomiting; no other Grade 3 or 4 toxicities were observed. Twelve treatment sites (14%) were complicated by subsequent vertebral fractures., Conclusions: Stereotactic body radiotherapy for RCC metastases to the spine offers fast and durable pain relief with minimal toxicity. Stereotactic body radiotherapy seems optimal for patients who have solitary or few spinal metastases. Patients with neural foramen involvement are at an increased risk for failure.
Published: 2012
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47. The efficacy of external beam radiotherapy and stereotactic body radiotherapy for painful spinal metastases from renal cell carcinoma.

Author: Hunter GK, Balagamwala EH, Koyfman SA, Bledsoe T, Sheplan LJ, Reddy CA, Chao ST, Djemil T, Angelov L, and Videtic GMM
Abstract: Purpose: Palliative radiotherapy is routinely used to treat painful spinal metastases from renal cell carcinoma (RCC). Conventionally planned external beam radiotherapy (CRT) has been standard, with high-dose stereotactic body radiotherapy (SBRT) becoming increasingly common given the radioresistant nature of RCC. We compared the efficacy and durability of pain relief produced by these 2 modalities., Methods and Materials: Patients with painful spinal metastases from RCC treated from 2002-2010 were included. Response was defined similar to the Radiation Therapy Oncology Group 0631 protocol: complete response (CR) being resolution of pain without increased narcotics; partial response (PR) included patients with an incomplete reduction in pain without increased narcotics. Patients who experienced a CR or PR were coded as having pain relief, while those with persistent pain or additional narcotics requirements were coded as failures. Achievement of pain relief was analyzed using competing risk analysis with death as the competing event. Time to pain relief was plotted using cumulative incidence analysis., Results: A total of 110 patients (34 CRT; 76 SBRT) were included. Median follow-up was 4.3 months (range, 0.2-38). Median Karnofsky performance score was higher for patients treated with SBRT compared with CRT (80 vs 70; P = .0004). Overall pain response rates were 68% for CRT and 62% for SBRT, with respective CR and PR rates of 12% and 56% for CRT, and 33% and 29% for SBRT (P = .01). Median time to pain relief was 0.6 weeks for CRT versus 1.2 weeks for SBRT (P = .29). For patients who achieved pain relief (n = 79), median duration was 1.7 months for CRT versus 4.8 months for SBRT (P = .095). On univariate analysis no factors were significantly related to pain relief., Conclusions: CRT was not statistically different than SBRT for pain relief in symptomatic spine metastases from RCC and should be used as first line treatment. The appropriate use of SBRT in this population merits prospective study., (Copyright © 2012 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.)
Published: 2012
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48. SU-E-T-423: Dosimetric Effect of Rotation on Stereotactic Body Radiotherapy (SBRT) of the Spine.

Author: Djemil T, Angelov L, and Chao S
Abstract: Purpose: To study the dosimetric effects of the residual setup rotation errors in spine SBRT., Methods: We selected 25 patients with 26 lesions from an IRB approved registry. All patients were setup with Exactrac IGRT and treated with Novalis. Excatrac provided 6D shifts (3 translational, 3 rotational). The translational shifts were corrected by moving the couch. The rotational shifts >2 degrees were corrected by repositioning the patient, while smaller shifts were ignored. For each patient, we rotated the simulation CT rigidly around the CTV center by the recorded residual angles, using the MIM 4.22 software. The resulting rotated CT with all contours were imported into the TPS. The clinical plans used for treatment were mapped onto the rotated CT. Dosimetric endpoints were extracted for the rotated CTV (mean, max, D90) and the rotated cord (D0.1cc, D1cc, V10, max). These endpoints were compared to those from the clinical plan., Results: For the CTV, the average ratio of the mean doses was 1.001 (0.996-1.004), the average ratio of D90 was 1.003 (0.998-1.011), and the average ratio of the maximum doses was 1.005 (0.995-1.029). For the cord, the average ratio of DO.lcc was 1.01 (0.94-1.06), the average ratio of D1cc was 1.036 (0.92-1.23), the average max doses ratio was 1.03 (0.95-1.11), and the average V10 ratio was 1.43 (0.56-2.78)., Conclusions: Rotational errors in patient setup as small as 2 degrees do have dosimetric effects in spine SBRT treatments. The use of a robotic table to eliminate translational and rotational shifts is strongly recommended. It is important to note that, eventhough, the residual rotations resulted in up to 11% variation (cord max dose) from the planned doses, none of these cases violated our clinical treatment plan acceptance criteria (tolerance of the critical organs)., (© 2012 American Association of Physicists in Medicine.)
Published: 2012
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49. SU-E-T-486: Volume and Location Dependence on the Difference Between Monte Carlo and Pencil Beam Dose Calculations for Lung Stereotactic Body Radiation Therapy.

Author: Zhuang T, Djemil T, Qi P, Magnelli A, Stephans K, Videtic G, and Xia P
Abstract: Purpose: Stereotactic body radiotherapy has been an efficacious treatment modality for early stage non-small cell lung cancer. The accuracy of dose calculations is in question due to the presence of inhomogeneity. It was required in several clinical trials to calculate dose without heterogeneity correction. However, to better correlate the outcomes with the planned dose, accurate dose calculation with heterogeneity correction is highly desirable., Methods: We compared the recalculated dose with Monte Carlo (MC) algorithm to the original Pencil Beam (PB) calculations for clinical lung SBRT plans. Thirty-one clinical plans that followed protocol guidelines were retrospectively investigated. Dosimetric parameters D1, D95 and D99 for the PTV and D1 for organs at risk were compared. Correlations of mean lung dose and V20 of lungs between two calculations were investigated., Results: Compared to the PB calculations without heterogeneity correction in clinical plans, we found that in terms of D95 of PTV, (1) the two calculations resulted in similar D95 for edge tumors with volumes greater than 25.1cc; (2) an average overestimation of 5% in PB calculations for edge tumors with volumes less than 25.1cc; and (3) an average overestimation of 9% or underestimation of 3% in PB calculations for island tumors with volumes smaller or greater than 22.6 cc, respectively. With heterogeneity correction, the PB calculation resulted in an average reduction of 23.8% and 15.3% in D95 for island and edge lesions respectively compared to the MC calculation. For organs at risks, no clinical meaningful differences were found among all the comparisons. Excellent correlations for mean dose and V20 of lungs were observed between the two calculations., Conclusions: Using a single scaling factor to account for the differences in using heterogeneity correction may not be sufficient. To understand dose-response relation in Lung SBRT, accurate dose calculation such as the Monte Carlo algorithms is highly recommended., (© 2012 American Association of Physicists in Medicine.)
Published: 2012
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50. SU-E-J-10: Accuracy of Image Guidance Using Cone-Beam CT with Multiple Breath Hold Using Active Breathing Coordination.

Author: Zhuang T, Magnelli A, Liu H, Qi P, Djemil T, Stephans K, Videtic G, and Xia P
Abstract: Purpose: To complete a CBCT for a treatment using ABC, multiple breath hold (BH) (>3) were used due to the slow gantry rotation and the short BH period. Inter-BH tumor position variability may introduce distortion in the reconstructed images. This study aims to determine a threshold of the inter-BH scan displacement so that the inconsistency can be identified from the CBCT images., Methods: A numerical phantom was constructed to represent the thorax region of a human body. To simulate the inter-BH displacements, known magnitudes of motion (s = 0, 1, 3, 5 mm) along the longitudinal direction were introduced for the 'tumor' and 'diaphragm' in the phantom. Two different irregular motion patterns (s1=s3=/=s2 and s1=/=s2=/=s3) during CBCT scans were tested. Furthermore, a physical phantom with a movable insert was scanned using a commercial CBCT system. The insert of the phantom was programmed to move in the longitudinal direction according to the same motion patterns as designed in the numerical simulations. Subsequently, nine CBCT's in 'half-fan' mode for the physical phantom were acquired with the insert in various positions. These CBCT images were then fused to the reference CT by aligning to either the body of the phantom or the 'tumor' inside the insert., Results: Based on numerical simulation, position variation >1mm can be observed from the reconstructed CBCT images. Based on acquired CBCTs of the physical phantom, position variations of >3mm or 5mm were observed, depending on the motion pattern during the data acquisition. Because of the use of half-fan mode, we observed the order of position displacements of the tumor during CBCT acquisition drastically affected the outcome of imaging registration., Conclusions: Using ABC device, the inter-BH variability during a CBCT acquisition affects accuracy of tumor localization. A patient individualized planning margin might be necessary to account for this effect., (© 2012 American Association of Physicists in Medicine.)
Published: 2012
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