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Trauma has always been a global public health issue and urgently needed to be solved. It has great practical significance for the research of trauma care system. There are two mainstream models of trauma care system in the world. One is the prehospital care represented by the United States and the United Kingdom, which emphasizes rapid transport, and the other is the prehospital care represented by France and Germany, which emphasizes on-site care. The trauma care system was deficient in most developing countries. During the past ten years, rapid progresses have been achieved in trauma care system construction in China which refers to "Chinese regional trauma care system(CRTCS)". CRTCS is established in one administrative region, with one large tertiary hospital as trauma center and five to six secondary hospitals as trauma care sites to form the closed-cycle regional trauma triage and transportation protocols. After several years of construction and implementation, CRTCS is considered to be a feasible new trauma care system in line with the characteristics of China's national conditions, which can significantly shorten the time of trauma treatment and reduce the mortality of trauma. It is worthy of reference for developing countries.创伤一直是世界各国普遍面临和亟需解决的重大公共卫生问题，创伤救治体系的研究具有重大现实意义。国际上有两种主流的创伤救治体系模式，一种是以美国、英国为代表的院前救治强调快速转运模式，另一种是以法国、德国为代表的院前救治强调现场救治模式。长期以来，发展中国家欠缺完整的创伤救治体系。近十余年来，中国在创伤救治体系建设方面取得飞速发展，建立了“中国区域性创伤救治体系（CRTCS）”。CRTCS以一个政府主辖区作为区域单位，以一家大型三级医院作为创伤救治中心，以区域内5~6家二级医院作为创伤救治点，建立院前急救团队、院内急救团队，以及院内创伤专科救治团队，并强化其救治能力，形成闭环式区域性创伤分拣、转运救治流程。经过数年的建设和实施，CRTCS被认为是符合中国国情特点的、切实可行的新型创伤救治体系，明显缩短创伤救治时间，降低创伤死亡率，可供发展中国家借鉴。.

Mitigation of Edge localized mode(ELM) has been achieved with different external actuators such as lower hybrid wave (LHW), mixture supersonic molecular beam injection(SMBI), and laser blow-off(LBO) impurity seeding on HL-2A. During these experiments, the pedestal turbulence enhancement is commonly observed, which is found closely related to ELM mitigation. The turbulence enhancement is caused by the externally driven the velocity shear rate without change of the turbulence correlation length, but correlated to its radial wavenumber spectral shift. A common plausible mechanism for the ELM mitigation with different external source input seems to be involved. A modified theoretical model based on the turbulence radial wavenumber spectral shift is used and successfully interprets the experimental observations. The simulation suggests that a critical growth rate of the most unstable mode, also identified by the experimental results, survives in the competition of the velocity shear rate, enhancing the turbulence intensity. An example of the LHW case is used and good agreements have been found between the experimental results and simulation results.

A branch of high-frequency Alfvénic modes is observed on the HL-2A tokamak. The electromagnetic mode can be driven unstably in the plasma with an off-axis neutral beam heating. Its mode frequency keeps almost unchanged or presents a slow-sweeping behavior, depending on the detail current evolution. The poloidal and toroidal mode numbers are m/n = 1/1. The mode has a quite short duration (≤20 ms) and usually appears 5–10 ms after the neutral beam being injected into the plasma. Hybrid simulations based on M3D-K have also been carried out. The result suggests that co-passing energetic particles are responsible for the mode excitation. The simulated mode structures are localized nearby location of minimum safety factor (q min) and agree with the structures obtained through tomography of soft x-ray arrays. Further, the modes are localized in the continuum gap and their frequencies increase with variation of q min in a wide range. Last but not least, the characteristic of unchanged frequency on experiment is also reproduced by the nonlinear simulation with a fixed safety factor. All those evidences indicate that the n = 1 high-frequency mode may belong to a reversed shear Alfvén eigenmode.

OBJECTIVE: To study the effects of ulnar styloid and sigmoid notch fractures on postoperative wrist function in patients with distal radius fracture. METHODS: In total, 139 patients treated for distal radius fracture in the Department of Orthopedic Trauma at Peking University People’s Hospital from Jan. 2006 to June 2016 were selected for outpatient follow-ups. Evaluation was based on Sartiento’s modification of the Gartland and Werley scores. Efficacy was assessed with wrist pain as the focus. RESULTS: The excellent and good efficacy rate was 97.1% (excellent: n=107, 77.0%; good: n=28, 19.4%; and fair: n=4, 2.9%). Gender, age, and whether the ulnar styloid fracture achieved union did not significantly impact the scores (P>0.05). The scores of the basal fracture group were significantly different (P=0.001). Internal fixation of ulnar styloid fracture was associated with a significant difference in scores (P=0.005). The effect of sigmoid notch fracture was also associated with a significant difference in scores (P=0.024). This study included 22 cases of ulnar wrist pain, and the overall incidence of ulnar wrist pain was 15.8%. Gender, age, whether the ulnar styloid fracture achieved union, and whether internal fixation was conducted for ulnar styloid fracture and sigmoid notch fracture had no significant effect on the occurrence of ulnar wrist pain (P>0.05). The incidence of ulnar wrist pain was higher in basal fractures than that in tip fractures. Among ulnar styloid fractures, the union rate of basal fracture was higher than that of tip fractures. The union rates of basal fracture and tip fracture were significantly different (P

OBJECTIVE: To explore the effect of multi-disciplinary team (MDT) in general hospitals on severe trauma patients. METHODS: This study reviewed the treatment of patients with severe trauma in trauma center of Peking University People's Hospital from March 2017 to April 2019. The baseline information: the patients' gender, age, injury mechanism, etc.; the start indicators: the Glasgow coma scale (GCS), trauma index (TI), injury severity score (ISS); the start related indicators: time for activation, time for MDT to arrive, time for CT scan, time for damage control surgery; patient treatment and prognosis: ICU (intensive care unit) length of stay, number of cured and discharged patients, number of dead cases, number of patients transferred to rehabilitation hospital, were all analyzed. It discussed the composition of MDT, the initiation scheme, the indicators of initiation of MDT for severe trauma, and analyzed the correlation between the application of MDT and the prognosis of patients. RESULTS: From March 2017 to April 2019, 112 trauma patients were treated by MDT in Peking University People's Hospital. There were 69 males and 43 females. The minimum age was 15 years, the maximum age was 89 years, most of them were 36-55 years old. The main injury mechanism was traffic accident injury. The GCS, TI, ISS were 13.0±2.9, 13.0±2.8, and 21.5±11.9, respectively. It took 3.7±0.8 minutes to start the call, 6.1±0.9 minutes for MDT personnel to arrive at the emergency rescue area, 23.8±3.0 minutes for fast CT and 92.6±15.4 minutes for injury control operation. All the hospitalized patients were treated effectively. ICU (Intensive care unit) hospitalization time was 12.6±6.7 days. 55 discharged patients were cured, 5 died (1 died of hemorrhagic shock, 4 died of severe brain injury) and 52 transferred to rehabilitation hospital. CONCLUSION: The treatment of severe trauma patients by MDT in trauma center of general hospitals can greatly improve the ability and level of treatment of severe trauma patients, make up for the lack of treatment of severe trauma especially multiple trauma patients in large general hospitals, and improve the treatment effect of severe trauma patients. It provides a reference model for large general hospitals to treat patients with severe trauma and multiple trauma and for the construction of trauma centers.

Energetic electrons driving low-frequency magnetohydrodynamic instabilities, e.g., electron fishbone (eFB) modes and electron beta-induced Alfvén eigenmodes (eBAEs), are found in co- and counter-current drive low hybrid current drive (LHCD) plasma in HL-2A, respectively. The eBAEs are found in LHCD plasma for the first time. Two branches eFB modes are observed in the core of plasma, and they can transit from the high-frequency one to the low-frequency one continuously. The different mode structures and positions are obtained by tomography of soft x-ray arrays. The frequency jump phenomena of eFB modes are also found. Two eBAEs, with poloidal and toroidal mode numbers m/n = 3/1 and 5/2, are found in the edge of the plasma. The single m/n = 3/1 mode is found when the LHCD power (P LHCD) is 0.44 MW. The strong m/n = 5/2 mode coexists with the weak 3/1 mode when P LHCD = 0.52 MW. Although the current drive direction of LHCD is opposite to the plasma current, the two eBAEs also propagate in the electron diamagnetic drift direction poloidally, which is the same direction as the eFB modes in co-current drive LHCD plasma. With increasing P LHCD (or changed current profile), the value of the edge safety factor (q) decreases. The evolutions of the mode numbers of eBAEs may be related to changes in the edge q factors.

With a newly installed 5-channel W-band Doppler reflectometer (DR) in EAST tokamak, many interesting coherence modes and turbulences have been observed. In this paper, the tearing mode (TM), a novel inter-edge localized mode (ELM) electromagnetic mode, and the eigenmode geodesic acoustic mode (GAM) accompanied by a broadband quasi-coherent mode (QCM) during H-mode stage have been reported. The TM could be directly observed in both density fluctuation and perpendicular velocity fluctuation at the DR channel localized in the magnetic island region; moreover, many high-order TM frequency harmonics, dual turbulence peaks inside and outside the island separatrix, and strong flow shear across the island separatrix could also be observed. A high-frequency ( ∼ 230 kHz) electromagnetic mode (toroidal mode number n = 1) could be identified. The mode is generated dozens of milliseconds before the ELM crash and may affect the ELM dynamic process. The eigenmode GAM excited during the H-mode stage is generated near the top of the density pedestal and then propagates radially inward with a radial wavenumber of about 1 cm − 1. A broadband QCM with a frequency range of 20 – 100 kHz is always accompanied by eigenmode GAM and nonlinearly coupled with both GAM and the background turbulence from the bispectrum analysis. All these results convince the validity of the Doppler reflectometer in multi-scale measurement from the mesoscale to microscale.

With the great progress of the economy, the level of industrialization has been increasing year by year, which leads to an increase in accidental trauma accidents. Chinese annual death of trauma is already more than 400 000, which makes trauma the fifth most common cause of death, following malignant tumor, heart, brain and respiratory diseases. Trauma is the leading cause of the death of young adults. At the same time, trauma has become a serious social problem in peace time. Trauma throws great treats on human health and life. As an important part in the medical and social security system, the emergency of trauma system occupies a very important position in the emergency medical service system. In European countries as well as the United States and also many other developed countries, trauma service system had a long history, and progressed to an advanced stage. However, Chinese trauma service system started late and is still developing. It has not turned into a complete and standardized system yet. This review summarizes the histories and current situations of the development of traumatic first aid system separately in European countries, the United States and our country. Special attentions are paid to the effects of the pre- and in-hospital emergency care. We also further try to explore the Chinese trauma emergency model that adapts to the situations of China and characteristics of different regions of China. Our review also introduces the trauma service system that suits the situations of China proposed by Professor Jiang Baoguo's team in details, taking Chinese conditions into account, they conducted a thematic study and made an expert consensus on pre-hospital emergency treatment of severe trauma, providing a basic routine and guidance of severe trauma treatment for those pre-hospital emergency physicians. They also advised to establish independent trauma disciplines and trauma specialist training systems, and to build the regional trauma care system as well as the standards for graded treatment, thus establishing a multiple disciplinary team (MDT) of severe trauma. In this way, we can reduce the mortality and disability risks of severe trauma, improve the quality of patients' life, and save more lives.

Hexagonal boron nitride hBN ceramic was successfully fabricated by pressureless sintering at 2100C using submicrometre hBN powders without any sintering additive. The as-prepared hBN ceramic showed a room temperature flexural strength of 30.7MPa. Its flexural strength increased with the increment of temperature in N2 atmosphere, and it retained a strength of 57.2MPa nearly two times of the room temperature strength at 1600C due to clean grain boundaries with no glassy phase. Additionally, the as-prepared hBN ceramic showed a high thermal conductivity of 31.76Wm1k1 and a good thermal shock resistance, which retained a relatively high residual flexural strength of 22.6MPa 73.5 of the original flexural strength at T800C. The as-prepared hBN ceramic presents a good application prospect at high temperature.

Our previous epidemiological study revealed that co-exposure of [Cr(VI)] with small amount of heavy metals could induce peripheral blood element imbalance, but little was known about the contribution of Cr(VI) itself and the multi-element distribution profile in other target tissues. We explored element homeostasis in the blood, RBC, serum and lung after Cr(VI) exposure and Zn intervention. 60 Sprague-Dawley male rats received intratracheal instillation of Cr(VI) (0, 0.063, 0.630mgCr/kg) weekly and/or intragastric administration of zinc sulfate (0, 10mgZn/kg) daily for one month. Element contents and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) concentrations were determined. Dose-response relationship was observed among rats exposed to Cr(VI). Ca, Mg, Mn in the blood, Fe, Mg, Se in the serum, and Mg and Zn in lung tissue decreased significantly, while Ca, Co, Cr, Mg, Mn, Se in RBC, and Ca, Co, Mo in the lung increased after Cr(VI) exposure. The alteration trends manifested differently, with RBC the most sensitive. Cr induced increase of urinary 8-OHdG, which decreased after Zn intervention. Zn intervention could help to restore element homeostasis after Cr(VI) exposure, especially for Ca, Fe, Mg and Se.

Cr(VI) is widely-recognized as occupational and environmental contaminant, but the precise underlying mechanisms of Cr(VI) induced carcinogenic toxicity remain to be elucidated. Among kinds of toxic mechanisms, alteration of protein profiling usually elaborate a key mechanism of Cr(VI) induced toxicity and carcinogenesis. Large-scale proteins changes can reflect the onset or progression of carcinogenic toxicity, and potential serum protein biomarkers of Cr(VI) exposure. To gain an insight into the serum proteins expression profiling in chromate workers and find potential novel serum proteins biomarkers of Cr(VI) exposure, 107 male participants from a chromate production plant were recruited into the study. Questionnaire was applied to collect personal information and occupational history. Chromium concentration in blood (CrB) was measured to evaluate the participants' internal exposure. Serum proteins profiling and bioinformatics analysis were performed to explore differentially expressed proteins, proteins-chemical interaction network, critical proteins nodes related to the signaling pathways among 16 controls and 25 exposure workers in the first stage. ELISA tests were applied to verify the critical interested proteins nodes in the remaining 41 exposure workers and 25 controls. The results showed that the CrB levels in the control group were significantly lower than that in the exposure group (P0.05). 44 significantly differentially expressed serum proteins formed 16 significant signaling pathways and a complex proteins-chemical interaction network, which associated with the immune system and extracellular matrix organization. C reactive protein (CRP), sonic hedgehog protein (SHH) and calcium located at critical nodes in proteins-chemical interaction network. There was a significant negative correlation between serum CRP level and CrB (P0.05), and a significant positive correlation between SHH concentrations and CrB (P0.05), which indicated that CRP and SHH might be as the potential novel biomarkers of Cr(VI) exposure. Also, the current study preliminarily paved the way to further functional studies to understand the underlying mechanisms and novel serum biomarkers of Cr(VI) exposure.

To invstigate the mechanism of new mechanically-activated cation channel protein (Piezo1) can cause the apoptosis of the human chondrocytes under compressive loading, using a Flexercell unit by activating classical Mitogen-activated protein kinase (MAPK) signal pathyway(ERK1/2).Primary human chondrocytes were isolated, cultured, and then subjected to the static compressive loading for 0, 2, 12, 24, 48 h, respectively.The expressions of Piezo1 and the ERK1/2 were assessed by reverse transcription-polymerase chain reaction(PT-PCR), as well as the apoptosis gene B cell lymphoma/leukemia-2(Bcl-2) Bel-associated X protein(Bax). In addition, Piezo1inhibitor, Grammostola spatulata mechanotoxin 4(GsMTx4), was used to block Piezo1, served as a positive control.The immunofluorescence was used to locate the expression of Piezo1 protein and ERK1/2.AnnexinV-PI was used to detect the apoptosis of chondrocytes.The expression of the Piezo1 in chondrocytesis was weak, the 12 h group was significant increased(0.198 1 vs 0.021 4, P0.05), the 24 h group was the highest expression while the expression of the 48 h group was lower than the 24 h group, as well as the ERK1/2, Bcl-2 and caspase3.The result of AV-PI had shown that the 2 h group had increased early stage of apoptosis.The 12 h group had increased late stage of apoptosis, and the 24 h group's apoptotic rate was the highest, while the apoptotic rate of the 48 h group was lower than the 24 h group(0.497 1 vs 0.743 1, q=0.035 9). The GsMTx4 could inhibit the late stage of apoptosis, and the location of the Piezo1 was expressed in the nucleus and cytoplasm of the chondrocytes.Piezo1 plays an important role in the apoptosis of the human chondrocyte through the classic MAPK/ERK1/2 signal pathway.

The invasive success of the exotic Argentine ant [Linepithema humile (Mayr)] is often closely tied to year-round availability of water sources. Previous studies suggest that the location of such water sources can strongly influence activity patterns of colonies and may be a key predictor of building infestations. We studied activity patterns of Argentine ants in relation to water and food resources in two open-air structures (aviaries). In one series of manipulations, ant activity inside the aviaries was significantly reduced with the placement of numerous water sources around the outside. Inside activity increased again when the outside water sources were removed. A second series of manipulations involved the placement of water sources at targeted locations outside of the structures. Ant activity inside the aviaries consistently shifted significantly closer to these targeted sites. The results suggest that providing a reliable water source to Argentine ant colonies exterior to buildings can be a non-chemical method of integrated pest management for reducing ant infestations. Independent of our manipulations, L. humile activity levels predictably declined with time of day, but these changes were uncorrelated with observed surface temperatures. In fact, activity was often noted at surface temperatures higher than those that cause worker mortality under laboratory conditions. This suggests that L. humile exhibits a consistent temperature-independent circadian activity pattern of reduced foraging in afternoons relative to mornings.

To apply modified proximal femoral nail anti-rotation (PFNA) fixation techniques performed by percutaneous placement of guide wire combined with true lateral view and to make the procedures simpler.A retrospective study was used to analyze the clinical data of femoral intertrochanteric fractures cases, which were treated with conventional PFNA fixation or modified PFNA fixation performed by percutaneous placement guide wire combined with true lateral view in our hospital, from March, 2011 to May, 2014. In the study, 60 cases were followed for average 13 months. The operation time, the amount of bleeding, the fluoroscopy time, postoperative radiographic measurements (tip apex distance, TAD) and hip function scores were analyzed.In modified PFNA group, the amount of bleeding, the operation time and the fluoroscopy time were (34.9±6.1) mL, (70.5±12.5) min, (63.6±9.7) s respectively. In conventional PFNA group,they were (47.8±6.7) mL, (80.6±17.1) min, (68.5±8.7) s respectively. There were significant differences in the above respects between the two groups (P were 0.006, 0.013, and 0.022 respectively). There were no significant differences in TAD, fracture healing time, postoperative hip scores between the two groups (P0.05).Fracture line is a natural entry point for some cases of femoral intertrochanteric fractures when we use proximal femoral nail anti-rotation to fix the fracture. Applying percutaneous insertion of the guide pin combined with true lateral view could reduce the operation time, amount of bleeding, and fluoroscopy time significantly, make the procedures simpler and acquire satisfactory results .

To measure vertical axis length of humerus head in patients with proximal humeral fractures and to evaluate the use of structure screws in proximal humerus internal locking osteosynthesis system (PHILOS).From January 2007 to February 2014,117 patients with proximal humerus fracture were treated by PHILOS plate. Preoperatively, all the patients tookanteroposterior X-ray of shoulder, and the vertical axis length of humerus head were measured, and the use of structure screws in PHILOS plate was observed.There were 40 male and 77 female patients; The vertical axis length of humerus head in male patients was (47.64±3.44) mm, and the rate of structure screw use was 52.5%; The vertical axis length of humerus head in female patients was (42.46±3.21) mm, and the rate of structure screw use was 32.5%. The vertical axis length of humerus head and the rate of structure screw use had significant difference in the male and female groups (P0.05).The rate of structure screw use was low in the treatment of proximal humerus fracture by PHILOS plate, especially for women. We should improve the design of plate according to the anatomical characteristics of Chinese.

To investigate the characteristics and perioperative management of hemophilia patients with fracture.Retrospectively, we analyzed 8 patients with hemophilia combined with fracture, who were admittted to our department from 2005 to 2013. Six patients were with hemophilia A and two with hemophilia B; Based on the severity of hemophilia, 2 cases were light, 3 moderate and 3 severe; Based on the location of fracture, 4 cases were femoral neck fractures, 1 femoral intertrochanteric fracture, 1 bilateral distal femur fractures, 1 tibiofibula fracture, and 1 humerus intercondylar fracture. Blood coagulation factor replacement therapy was conducted preoperatively, intraoperatively and postoperatively, All the patients underwent closed or open reduction and internal fixation or joint replacement. Also, we analyzed the perioperative complications and observed whether the fracture healed.The average age was 33.5 years (14 to 47 years); In 6 cases, fractures occurred at femur, accounting for 75% of all the fractures; Femoral neck fracture was treated by closed reduction and hollow screws fixation; Femoral intertrochanteric fracture, distal femur fracture, and tibiofibula fracture were treated by open reduction and internal fixation with plate; Humerus intercondylar fracture was treated by elbow joint replacement. Intraoperative bleeding was from 50 to 600 mL, an average of 262 mL; Perioperatively, the average use of FVIII/activated prothrombin complex concentrates (APCC) was 358 U/kg (125 to 554 U/kg). Postoperatively, poor wound healing was observed in 2 patients, and the condition improved after symptomatic treatment; In patients with internal fixation, all the fractures united, and the average healing time was 14 weeks. No complications such as fixation loosening or rupture occurred after internal fixation.Hemophilia combined with fracture mainly occurred in the young, and the site of fracture was given priority to femur. With perfect preoperative preparation, on the basis of the replacement therapy, hemophilia combined with fractures was safe for surgical treatment, and postoperative fractures healing wasgood. But the risk of poor wound healing was high.

Trauma is a global social problem, with the number of deaths up to 5.8 million all over the world annually. Currently, severe trauma has become the first cause of death in young adults in China. Nowadays, there are many problems in the trauma rescue system, including long pre-hospital transfer period, several secondary transfers, no information exchange between pre-hospital and in-hospital care, and the poor integrated treatment, which results in the situation that the overall treatment level of severe trauma in China is relatively low. In order to solve these problems, we carried out the research and promotion of severe trauma rescue standard, involving completing severe trauma information database, providing local rescue medical workers with standard training, and building up the information system for the linkage and warning of severe trauma. In addition, we developed and promoted the new standard system for severe trauma in 15 cities with 124 medical centers. Due to our research, the treatment ability of severe trauma in the pilot areas was enhanced, and the mortality and morbidity of severe trauma were reduced significantly. To sum up, we had got the expected results after implementing the project.

Au/In isothermal solidification technique was evaluated as an alternative method for high performance die attachment. Bonding could be achieved at temperatures between 250°C ‐ 3008C for about five to ten seconds. The microstructures of the bonds were studied and their effects on the reliability analysed. The quality of the bonds depends very much on the surface waviness of the substrate. For high quality substrates, bonding was successfully achieved on 3mm × 3mm dies, which is almost one order of magnitude bigger than the die size achievable for Au/Si eutectic bonding, and the bonds show no obvious degradation after 2,800 cycles between –55°C to 125°C.

A gold-indium isothermal solidification technique has been developed for die bonding. Both silicon on silicon and silicon on alloy 42 (chip size 2 × 2 mm2) are investigated. For silicon on silicon, the bonding is performed at 200°C within 30 sec. The bonds can withstand 1,500 cycles of temperature cycle between −65°C and 150°C without any degradation. For silicon on alloy 42, the bonding is done at 250°C within 5 sec. The bonds can pass the shear strength test specified by MIL STD 883D, Method 2019.5. The reliability of the bonds is evaluated by thermal cycle testing. After 500 cycles between −65°C and 150°C, only slight degradation was observed.

Insulin-dependent diabetes mellitus (IDDM) is the result of a T-cell mediated autoimmune beta-cell destruction, which is accompanied by autoantibodies. We analysed the cellular and humoral immune response to insulin and insulin peptides in patients with recent-onset IDDM, IDDM patients treated with insulin, non-diabetic first degree relatives and unrelated control subjects. There were no differences in T-cell reactivity to whole insulin or insulin peptides in general between age-matched groups of IDDM patients, relatives or healthy control subjects. In contrast to investigations in NOD mice, no immunodominant or disease-specific insulin peptide could be identified. Surprisingly, a positive correlation of T-cell responses to insulin with age was noticed (p < 0.005). This resulted in an inverse relation of insulin autoantibodies (IAA) and insulin reactive T-cells (p < 0.001) together with the well-described negative correlation of IAA with age. Interestingly, insulin-treated patients differed from age-matched recent-onset IDDM patients: first, simultaneous immune recognition of insulin with T-cells and IAA was only seen in patients treated for 6 months with insulin; second, insulin-treated patients rarely responded to whole insulin; third, they displayed less determinant spreading, and finally, recognition of multiple insulin peptides was not accompanied by crossreactivity to whole insulin. These distinct observations in insulin-treated IDDM patients, together with the inverse correlation between humoral and cellular responses to insulin, may result from activation or modulation of different T-cell subsets, and may be of relevance to insulin therapy trials, in which selective activation of non-destructive T-cell subsets may be a key to successful intervention.

An improved method for subtractive cloning with enhanced efficiency was developed by modifying the enzymatic degrading subtraction. The thionucleotide-modified tester cDNA fragments under control of one linker-primer were hybridized with excess driver cDNA fragments flanked by the other distinct linker-primer. After selective digestion of incompletely protected tester/driver and of unprotected driver/driver molecules with exonuclease III and VII, the protected tester/tester reassociates due to thionucleotides were exclusively amplified by PCR with the tester-cDNA-specific primer. The subtractively enriched target cDNA fragments, showing distinct bands in an agarose gel, were inserted into pUC19, and random colonies with inserts were screened by Northern hybridization to tester and driver RNA. Four distinct clones were confirmed to be up-regulated by the withdrawal of potassium from the nutrient solution of seedling barley growing hydroponically. The original protocol generated only smeared amplicons due to non-selective PCR amplification of the hybridized cDNA mixture including remains of undigested driver cDNA.

Gate-metal-related kink effects in InAlAs∕InGaAs∕GaAs metamorphic high-electron-mobility transistors have been investigated. Improvements on the kink effect have been observed by using the higher Schottky barrier height gate alloys, including Ti∕Au, Ni∕Au, and Pt∕Au, as compared to the use of the conventional Au gate metal. In comparison with gate alloy combinations, the devices with Ti∕Au alloy exhibit superior noise characteristics, whereas those with Ni∕Au alloy demonstrate the highest power characteristics. With the gate dimensions of 1.2×200μm2, the device minimum noise figure, NFmin, is 1.17dB at 2.4GHz by using Ti∕Au and the output power is 13.14dBm at 2.4GHz by using Ni∕Au. Significant rf characteristics have also been improved upon that with Au gate.

In this article, a Bayesian tomography method using non-stationary Gaussian process for a prior has been introduced. The Bayesian formalism allows quantities which bear uncertainty to be expressed in the probabilistic form so that the uncertainty of a final solution can be fully resolved from the confidence interval of a posterior probability. Moreover, a consistency check of that solution can be performed by checking whether the misfits between predicted and measured data are reasonably within an assumed data error. In particular, the accuracy of reconstructions is significantly improved by using the non-stationary Gaussian process that can adapt to the varying smoothness of emission distribution. The implementation of this method to a soft X-ray diagnostics on HL-2A has been used to explore relevant physics in equilibrium and MHD instability modes. This project is carried out within a large size inference framework, aiming at an integrated analysis of heterogeneous diagnostics.

Polarization-independent and omnidirectional tunable bandpass filters have been proposed and demonstrated. It is seen that a bilayer period structure composed of single-negative materials can act as a tunable filter, which can be changed from a filter with two symmetrical passband to one with a single pass bandpass, or from one with a wide to one with a narrow pass band. Moreover, the proposed filter is insensitive to the incident angle and polarization of light, which is an omnidirectional, polarization-independent filter for incidence angles between 0° to 90°.

Trititrigia (Triticum sect, trititrigia) is an artificially produced perennial wheat from the hybridization of durum wheat (T. durum, 2n=28) and intermediate wheatgrass (Elytrigia intermedia=Ely mus hispidus=Agropyron intermedium= Thinopyrum intermedium, 2n=42), which both belong to the tribe Triticeae in the family Gramineae. Durum wheat, the main tetraploid type of wheat, is mainly grown in relatively drier regions, embracing the Mediterranean basin, India, the former USSR, and the low rainfall areas of the great plains in the USA and Canada (Feldman 1976).

Maize (Zea mays, 2n = 20) is a cereal crop originating in the tropics, with C4 photosynthesis, belonging to the tribe Maydeae, subfamily Panicoideae, family Gramineae (Hutchinson 1959). It is cultivated in most parts of the world from 58° north to 40° south, covering the tropical, subtropical, and intermediate climates (Wilsie 1962). Its global production reached about 475 million metric tons and occupied 24% of all grains in the world in 1990. The chief maize- producing regions are the USA (42.4%) and China (18.4%), which provided more than 60% of the world total (FAO 1990).

Non-diffraction guiding modes covering the full broad band of a photonic crystal with elliptical rods for TM mode are reported in this paper. All such modes can be used to effectively guide electromagnetic waves since they have near-zero group velocity components along the ΓX′ direction. In the fourth dispersion surface of the photonic crystal, the two wide flat regions spanning the first Brillouin zone possess unique properties: one dimension corresponds to a broad band, while the other corresponds to full incident angles of 0–90°. These properties have many potential applications; as an example, here a broadband all-angle supercollimation with a bandwidth of 169 nm around 1550 nm is demonstrated. For the inverted structure of elliptical holes in a dielectric, similar results can be achieved over 140 nm around 1550 nm for TE mode.

PurposeThe aim of this study was to radiologically evaluate the risk of reduction loss after locking plate fixation of proximal humerus fractures.MethodsFrom September 2007 to April 2009, 71 patients (28 males, 43 females) with unstable proximal humeral fracture were treated with open reduction and internal fixation by locking plate. The mean follow-up time was 31.2 months (range: 26–47). The head-shaft angulation (HSA) and the humeral head height (HHH) in true anteroposterior (AP) were recorded and compared over time. All complications were noted. Shoulder function was measured by the Constant score.ResultsPatients with ΔHSA >10° (t=2.740, P=0.008) and ΔHHH >5mm (t=2.55, P=0.019) were more likely to have impaired shoulder function. Varus collapse occurred most frequently in patients with initial reduction of HSA 5mm HHH decrease were strongly associated with loss of reduction (χ2=24.23, P10° and HHH >5mm were radiological factors that indicated poor shoulder function. Intra-operative HSA >125° should be achieved to avoid reduction loss following locking plate fixation of proximal humerus fracture.Level of evidencelevel IV.