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To compile a personalized program for correcting the metabolism of a professional athlete, it is necessary to take into account many factors, including age, gender, sports specialization, individual characteristics, the pathologies in the anamnesis, the stage of the athlete’s training cycle, etc. When drawing up such programs for athletes of sports national teams of the Russian Federation, a scheme for assessing the characteristics of the athlete’s body is used, the basis for which is information obtained during in-depth medical examinations of athletes conducted on the basis of clinics of the FMBA Russia. To improve the quality of personalized programs of metabolic correction in the future, it is possible to use professionally oriented reference intervals of laboratory blood parameters, as well as the results of genetic screening based on the strategy of complete exomic sequencing of the athlete’s genome. One of the ways to increase the efficiency of metabolic correction of professional athletes is the introduction of modern information technologies and the development of a modern information system based on them. The introduction of such an information system will increase the speed of primary processing of initial information about the health status of the athlete and the peculiarities of his metabolic processes, as well as partially automate the formation of individualized recommendations regarding the diet and hydratation, and the choice of metabolic correction at various stages of the sports season.

Glutamine (GLN) and glutamic acid (GLA) are involved in many metabolic processes, from nucleotide synthesis to nerve impulse conduction; GLN is also an energy substrate for immunocompetent cells, making it an important link in the immune response. In stressful situations, which include significant physical activity, plasma levels of GLN and GLA decrease as a result of the amino acid being actively consumed in many biochemical reactions. GLN deficiency can lead to a number of negative manifestations in athletes and adversely affect athletic performance. The purpose of this work was to study the effects of glutamine deficiency and the possible replenishment of the deficiency by the consumption of exogenous forms of the substance when using glutamine-containing products; special attention was paid to the study of transient decrease in immune function as a relevant factor that impairs the mode of sports training.

Objective: to reveal the frequency of deviations occurrence in individual biochemical indicators, which can be markers of hidden metabolicconditioned deviations in the health of athletes.Materials and methods. Members of sports teams of Russia at the age of 16 to 38 years were examined. The total number of examined athletes was 5245: 3167 were male athletes and 2078 were female athletes. We studied 25 indicators of the biochemical composition of blood, showing latent metabolic disorders and the activity of its regulators, negative shifts in the functional state of individual physiological systems of the body and possible damage to tissues of individual organs.Results. Reference ranges and their centile gradations were calculated on the basis of a large array of data for 25 biochemical parameters. The use of centile gradations in assessing the values of blood biochemical parameters, recorded during the current monitoring in athletes, makes it possible to establish the vector of their changes and timely make changes in the volume and orientation of training loads, as well as to reasonably develop individualized programs for the athlete’s metabolic support. The use of the centile approach and the formation on its basis of gradation scales for each of the studied blood biochemical parameters also made it possible to establish the percentage of persons with significant deviations in certain biochemical parameters among the studied sample of athletes, admitted to the training process within the framework of in-depth medical examinations (DMO).Conclusion: such deviations from the norm may indicate hidden metabolic disorders that occur against the background of professional sports loads, and in the absence of timely compensation, they can lead to a breakdown in adaptation and the development of various metabolic-related pathologies