1. The Absence of Interleukin 1 Receptor–Related T1/St2 Does Not Affect T Helper Cell Type 2 Development and Its Effector Function
- Author
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Kiyoshi Takeda, Shin-ichiro Kashiwamura, Tomohiro Matsuyama, Kozo Kuribayashi, Tohru Tsujimura, Katsuaki Hoshino, Kenji Nakanishi, Taku Kodama, and Shizuo Akira
- Subjects
Ovalbumin ,Immunology ,Interleukin-1 Receptor-Like 1 Protein ,Interleukin-1 receptor ,Biology ,interleukin 1 receptor family ,gene targeting ,Interferon-gamma ,Mice ,Th2 Cells ,medicine ,Animals ,Immunology and Allergy ,Mast Cells ,Interleukin 5 ,Cells, Cultured ,Interleukin 4 ,Strongylida Infections ,Interleukin 3 ,Inflammation ,Mice, Knockout ,Brief Definitive Report ,Membrane Proteins ,Proteins ,Receptors, Interleukin-1 ,Interleukin ,Receptors, Interleukin ,asthma ,Mast cell ,Cell biology ,Mice, Inbred C57BL ,Interleukin 33 ,medicine.anatomical_structure ,Nippostrongylus ,T helper cells types 1 and 2 ,mast cell - Abstract
T1/ST2, an orphan receptor with homology with the interleukin (IL)-1 receptor family, is expressed constitutively and stably on the surface of T helper type 2 (Th2) cells, but not on Th1 cells. T1/ST2 is also expressed on mast cells, which are critical for Th2-mediated effector responses. To evaluate whether T1/ST2 is required for Th2 responses and mast cell function, we have generated T1/ST2-deficient (T1/ST2−/−) mice and examined the roles of T1/ST2. Naive CD4+ T cells isolated from T1/ST2−/− mice developed to Th2 cells in response to IL-4 in vitro. T1/ST2−/− mice showed normal Th2 responses after infection with the helminthic parasite Nippostrongylus brasiliensis as well as in the mouse model of allergen-induced airway inflammation. In addition, differentiation and function of bone marrow–derived cultured mast cells were unaffected. These findings demonstrate that T1/ST2 does not play an essential role in development and function of Th2 cells and mast cells.
- Published
- 1999
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