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Purpose. To evaluate the hypotensive effect of endotrabeculectomy as a standalone operation and in combination with cataract phacoemulsification in patients with primary open-angle glaucoma. Methods. There were 88 patients (88 eyes) with open-angle glaucoma under our observation. The patients of the first group (23 patients, 23 eyes) underwent standalone endotrabeculectomy. The patients of the second group (65 patients, 65 eyes) underwent endotrabeculectomy in combination with cataract phacoemulsification and intraocular lens implantation. Results. When comparing the IOP of the two groups, we found that no significant difference in its decrease depending on the type of surgery was detected, in all cases p > 0.05. A significant difference was found only when comparing the “Before surgery” subgroups – p = 0.031. When comparing the usage of glaucoma medications, we found that at the first 6 months, no significant difference in quantities of drugs depending on the type of surgery was found (p > 0.05), but in the next 6 months, there were significantly higher amounts of glaucoma medications used in the frst group to reach the target IOP than in the second group, which can be explained by the slightly lower baseline IOP and the lower number of glaucoma medications instilled during the preoperative period in the second group. Conclusion. Endotrabeculectomy is an effective operation for patients with primary open-angle glaucoma, both as an stand-alone surgery and in combination with cataract phacoemulsification.