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Two virus system, The Friend leukaemia virus (FLV) and the Rous sarcoma virus (RSV), were introduced into tissue both in vitro and in vivo. Both brought about substantial modification of the activity of the Golgi apparatus detectable as such by specific radioautographic studies. This modification was accompanied by changes in the development and social behaviour of the cells with some differences being detectable between the in vivo and in vitro studies.

Although leukemia can be regularly induced in the mouse and rat by whole-body exposure to ionizing radiation, both spontaneous and radiation-induced leukemias are rare in the rhesus (Macaca mulatta) monkey. During the past ten years, personnel of this laboratory have been studying the acute and delayed effects of exposure to ionizing radiation in a large colony of these animals. The subject of this report concerns a single instance of leukemia occurring in our colony in an animal exposed to fractionated low doses of whole-body neutron irradiation.