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2. Description and basic evaluation of simulated mean state, internal variability, and climate sensitivity in MIROC6

Author

H. Tatebe, T. Ogura, T. Nitta, Y. Komuro, K. Ogochi, T. Takemura, K. Sudo, M. Sekiguchi, M. Abe, F. Saito, M. Chikira, S. Watanabe, M. Mori, N. Hirota, Y. Kawatani, T. Mochizuki, K. Yoshimura, K. Takata, R. O'ishi, D. Yamazaki, T. Suzuki, M. Kurogi, T. Kataoka, M. Watanabe, and M. Kimoto

Subjects
Geology, QE1-996.5
Abstract

The sixth version of the Model for Interdisciplinary Research on Climate (MIROC), called MIROC6, was cooperatively developed by a Japanese modeling community. In the present paper, simulated mean climate, internal climate variability, and climate sensitivity in MIROC6 are evaluated and briefly summarized in comparison with the previous version of our climate model (MIROC5) and observations. The results show that the overall reproducibility of mean climate and internal climate variability in MIROC6 is better than that in MIROC5. The tropical climate systems (e.g., summertime precipitation in the western Pacific and the eastward-propagating Madden–Julian oscillation) and the midlatitude atmospheric circulation (e.g., the westerlies, the polar night jet, and troposphere–stratosphere interactions) are significantly improved in MIROC6. These improvements can be attributed to the newly implemented parameterization for shallow convective processes and to the inclusion of the stratosphere. While there are significant differences in climates and variabilities between the two models, the effective climate sensitivity of 2.6 K remains the same because the differences in radiative forcing and climate feedback tend to offset each other. With an aim towards contributing to the sixth phase of the Coupled Model Intercomparison Project, designated simulations tackling a wide range of climate science issues, as well as seasonal to decadal climate predictions and future climate projections, are currently ongoing using MIROC6.

Published
2019
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3. Distributions and sources of low-molecular-weight monocarboxylic acids in gas and particles from a deciduous broadleaf forest in northern Japan

Author

T. Mochizuki, K. Kawamura, Y. Miyazaki, B. Kunwar, and S. K. R. Boreddy

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

To better understand the distributions and sources of low-molecular-weight (LMW) monocarboxylic acids (monoacids) in the forest atmosphere, we conducted simultaneous collection of gaseous and particulate samples at a deciduous broadleaf forest site in northern Japan. LMW normal (C1–C10), branched (iC4–iC6), hydroxyl (glycolic and lactic) and aromatic (benzoic) monoacids were detected in the gas and particle phases. The dominant LMW monoacids in gas phase were formic (mean: 953 ng m−3) and acetic (528 ng m−3) acids followed by propionic (37 ng m−3) or isopentanoic (42 ng m−3) acid. In the particle phase, isopentanoic (159 ng m−3) was dominant, followed by acetic (104 ng m−3) and formic (71 ng m−3) or lactic (65 ng m−3) acids. Concentrations of LMW monoacids did not show correlations with anthropogenic tracers such as nss-SO42- and NO3-, indicating that anthropogenic contribution is not important. Concentrations of C1–C6 monoacids in the gas phase showed positive correlations (r2=0.21–0.91) with isobutyric acid (iC4), which may be produced by microbial activity in soil. The forest soil may be a source of gaseous C1–C6 monoacids in the forest atmosphere. Acetic acid in the particle phase positively correlated with nonanoic acid (C9) (r2=0.63), suggesting that formation of acetic and nonanoic acids is associated with the oxidation of biogenic unsaturated fatty acids in the aerosol phase, in addition to photochemical oxidation of biogenic volatile organic compounds. The particle-phase fractions (Fp) of formic and acetic acids showed negative correlation with ambient temperature (C1: r2=0.49, C2: r2=0.60) but showed positive correlation with relative humidity (C1: r2=0.30, C2: r2=0.55) in daytime, suggesting that these meteorological parameters are important for the gas and particle portioning of monoacids in the forest atmosphere.

Published
2019
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5. Long-range atmospheric transport of volatile monocarboxylic acids with Asian dust over a high mountain snow site, central Japan

Author

T. Mochizuki, K. Kawamura, K. Aoki, and N. Sugimoto

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

To understand the long-range transport of monocarboxylic acids from the Asian continent to the Japanese islands, we collected snowpack samples from a pit sequence (depth ca. 6 m) at the Murodo-Daira snowfield near the summit of Mt. Tateyama, central Japan, in 2009 and 2011. Snow samples (n = 16) were analyzed for normal (C1–C10), branched chain (iC4–iC6), aromatic (benzoic and toluic acid isomers), and hydroxyl (glycolic and lactic) monocarboxylic acids, together with inorganic ions and dissolved organic carbon (DOC). Acetic acid (C2) was found to be a dominant species (average 125 ng g−1), followed by formic acid (C1) (85.7 ng g−1) and isopentanoic acid (iC5) (20.0 ng g−1). We found a strong correlation (r = 0.88) between formic plus acetic acids and non-sea-salt Ca2+ that is a proxy of Asian dust. Contributions of total monocarboxylic acids to DOC in 2009 (21.2 ± 11.6 %) were higher than that in 2011 (3.75 ± 2.62 %), being consistent with higher intensity of Asian dust in 2009 than in 2011. Formic plus acetic acids also showed a positive correlation (r = 0.90) with benzoic acid that is a tracer of automobile exhaust, indicating that monocarboxylic acids and their precursors are largely emitted from anthropogenic sources in China and/or secondarily produced in the atmosphere by photochemical processing. In addition, the ratio of formic plus acetic acids to nss–Ca2+ (0.27) was significantly higher than those (0.00036–0.0018) obtained for reference dust materials of Chinese loess deposits from the Tengger and Gobi deserts. This result suggests that volatile and semi-volatile organic acids are adsorbed on the alkaline dust particles during long-range atmospheric transport. Entrainment of organic acids by dusts is supported by a good correlation (r = 0.87) between formic plus acetic acids and pH of melt snow samples. Our study suggests that Asian alkaline dusts may be a carrier of volatile monocarboxylic acids.

Published
2016
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6. Emissions of biogenic volatile organic compounds and subsequent formation of secondary organic aerosols in a Larix kaempferi forest

Author

T. Mochizuki, Y. Miyazaki, K. Ono, R. Wada, Y. Takahashi, N. Saigusa, K. Kawamura, and A. Tani

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

We conducted simultaneous measurements of concentrations and above-canopy fluxes of isoprene and α-pinene, along with their oxidation products in aerosols in a Larix kaempferi (Japanese larch) forest in summer 2012. Vertical profiles of isoprene showed the maximum concentration near the forest floor with a peak around noon, whereas oxidation products of isoprene, i.e., methacrolein (MACR) and methyl vinyl ketone (MVK), showed higher concentrations near the canopy level of the forest. The vertical profile suggests large emissions of isoprene near the forest floor, likely due to Dryopteris crassirhizoma (a fern species), and the subsequent reaction within the canopy. The concentrations of α-pinene also showed highest values near the forest floor, with maximums in the early morning and late afternoon. The vertical profiles of α-pinene suggest its large emissions from soil and litter in addition to emissions from L. kaempferi leaves at the forest site. Isoprene and its oxidation products in aerosols exhibited similar diurnal variations within the forest canopy, providing evidence of secondary organic aerosol (SOA) formation via oxidation of isoprene most likely emitted from the forest floor. Although high abundance of α-pinene was observed in the morning, its oxidation products in aerosols showed peaks in daytime, due to a time lag between the emission and atmospheric reactions of α-pinene to form SOA. Positive matrix factorization (PMF) analysis indicated that anthropogenic influence is the most important factor contributing to the elevated concentrations of molecular oxidation products of isoprene- (> 64 %) and α-pinene-derived SOA (> 57 %). The combination of the measured fluxes and vertical profiles of biogenic volatile organic compounds (BVOCs) suggests that the inflow of anthropogenic precursors/aerosols likely enhanced the formation of both isoprene SOA and α-pinene SOA within the forest canopy even when the BVOC flux was relatively low. This study highlights the importance of intra-canopy processes that promote biogenic SOA formation in the presence of significant inflow of oxidants together with anthropogenic aerosols and their precursors.

Published
2015
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7. Neutron angular distribution in (γ, n) reactions with linearly polarized γ-ray beam generated by laser Compton scattering

Author

K. Horikawa, S. Miyamoto, T. Mochizuki, S. Amano, D. Li, K. Imasaki, Y. Izawa, K. Ogata, S. Chiba, and T. Hayakawa

Subjects
Linear polarized γ-ray, Photodisintegration reactions, M1 strength, Giant dipole resonance, Neutron angular distribution, Physics, QC1-999
Abstract

In 1957, Agodi predicted that the neutron angular distribution in (γ, n) reactions with a 100% linearly polarized γ-ray beam for dipole excitation should be anisotropic and universally described by the simple function of a+b⋅cos⁡(2ϕ) at the polar angle θ=90°, where ϕ is the azimuthal angle. However, this prediction has not been experimentally confirmed in over half a century. We have verified experimentally this angular distribution in the (γ, n) reaction for 197Au, 127I, and natural Cu targets using linearly polarized laser Compton scattering γ-rays. The result suggests that the (γ→, n) reaction is a novel tool to study nuclear physics in the giant dipole resonance region.

Published
2014
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8. Water-repellency and surface roughness with the structures of double layers using electroplated nickel deposit from a chloride bath

Author

Katsuhiko Tashiro, Yohei Kotsuchibashi, S. Tako, M. Nakayama, and T. Mochizuki

Subjects
Morphology (linguistics), Materials science, 020209 energy, Metals and Alloys, 02 engineering and technology, Surfaces and Interfaces, Surface finish, Condensed Matter Physics, Chloride, Surfaces, Coatings and Films, Mechanics of Materials, 0202 electrical engineering, electronic engineering, information engineering, medicine, Surface roughness, Composite material, Electroplating, Electroplated nickel, medicine.drug
Abstract

The authors have studied water-repellency technology using a roughness structure fabricated by electroplating. This paper examined the relationship between surface morphology and water-repellency o...

Published
2021
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10. Neutron tagging following atmospheric neutrino events in a water Cherenkov detector

Author

K. Abe, Y. Haga, Y. Hayato, K. Hiraide, K. Ieki, M. Ikeda, S. Imaizumi, K. Iyogi, J. Kameda, Y. Kanemura, Y. Kataoka, Y. Kato, Y. Kishimoto, S. Miki, S. Mine, M. Miura, T. Mochizuki, S. Moriyama, Y. Nagao, M. Nakahata, T. Nakajima, Y. Nakano, S. Nakayama, T. Okada, K. Okamoto, A. Orii, K. Sato, H. Sekiya, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, A. Takenaka, H. Tanaka, S. Tasaka, T. Tomura, K. Ueno, S. Watanabe, T. Yano, T. Yokozawa, S. Han, T. Irvine, T. Kajita, I. Kametani, K. Kaneyuki, K.P. Lee, T. McLachlan, K. Okumura, E. Richard, T. Tashiro, R. Wang, J. Xia, G.D. Megias, D. Bravo-Berguño, L. Labarga, B. Zaldivar, M. Goldhaber, F.d.M. Blaszczyk, J. Gustafson, C. Kachulis, E. Kearns, J.L. Raaf, J.L. Stone, L.R. Sulak, S. Sussman, L. Wan, T. Wester, B.W. Pointon, J. Bian, G. Carminati, M. Elnimr, N.J. Griskevich, W.R. Kropp, S. Locke, A. Renshaw, M.B. Smy, H.W. Sobel, V. Takhistov, P. Weatherly, K.S. Ganezer, B.L. Hartfiel, J. Hill, W.E. Keig, N. Hong, J.Y. Kim, I.T. Lim, R.G. Park, T. Akiri, B. Bodur, A. Himmel, Z. Li, E. O'Sullivan, K. Scholberg, C.W. Walter, T. Wongjirad, L. Bernard, A. Coffani, O. Drapier, S. El Hedri, A. Giampaolo, J. Imber, Th.A. Mueller, P. Paganini, B. Quilain, T. Ishizuka, T. Nakamura, J.S. Jang, K. Choi, J.G. Learned, S. Matsuno, S.N. Smith, J. Amey, L.H.V. Anthony, R.P. Litchfield, W.Y. Ma, D. Marin, A.A. Sztuc, Y. Uchida, M.O. Wascko, V. Berardi, M.G. Catanesi, R.A. Intonti, E. Radicioni, N.F. Calabria, G. De Rosa, L.N. Machado, G. Collazuol, F. Iacob, M. Lamoureux, N. Ospina, L. Ludovici, M. Gonin, G. Pronost, Y. Maekawa, Y. Nishimura, S. Cao, M. Friend, T. Hasegawa, T. Ishida, T. Ishii, M. Jakkapu, T. Kobayashi, T. Matsubara, T. Nakadaira, K. Nakamura, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, T. Boschi, F. Di Lodovico, J. Migenda, S. Molina Sedgwick, M. Taani, S. Zsoldos, K.E. Abe, M. Hasegawa, Y. Isobe, Y. Kotsar, H. Miyabe, H. Ozaki, T. Shiozawa, T. Sugimoto, A.T. Suzuki, Y. Takeuchi, S. Yamamoto, A. Ali, Y. Ashida, C. Bronner, J. Feng, T. Hayashino, T. Hiraki, S. Hirota, K. Huang, M. Jiang, T. Kikawa, M. Mori, A. Murakami, KE. Nakamura, T. Nakaya, N.D. Patel, K. Suzuki, S. Takahashi, K. Tateishi, R.A. Wendell, K. Yasutome, P. Fernandez, N. McCauley, P. Mehta, A. Pritchard, K.M. Tsui, Y. Fukuda, Y. Itow, H. Menjo, G. Mitsuka, M. Murase, F. Muto, T. Niwa, T. Suzuki, M. Tsukada, K. Frankiewicz, P. Mijakowski, J. Hignight, J. Jiang, C.K. Jung, X. Li, J.L. Palomino, G. Santucci, C. Vilela, M.J. Wilking, C. Yanagisawa, D. Fukuda, K. Hagiwara, M. Harada, T. Horai, H. Ishino, S. Ito, T. Kayano, A. Kibayashi, H. Kitagawa, Y. Koshio, W. Ma, T. Mori, H. Nagata, N. Piplani, S. Sakai, M. Sakuda, Y. Takahira, C. Xu, R. Yamaguchi, Y. Kuno, G. Barr, D. Barrow, L. Cook, A. Goldsack, S. Samani, C. Simpson, D. Wark, F. Nova, R. Tacik, J.Y. Yang, A. Cole, S.J. Jenkins, M. Malek, J.M. McElwee, O. Stone, M.D. Thiesse, L.F. Thompson, H. Okazawa, Y. Choi, S.B. Kim, I. Yu, A.K. Ichikawa, K. Ito, K. Nishijima, R.G. Calland, P. de Perio, K. Martens, M. Murdoch, M.R. Vagins, M. Koshiba, Y. Totsuka, K. Iwamoto, Y. Nakajima, N. Ogawa, Y. Suda, M. Yokoyama, D. Hamabe, S. Izumiyama, M. Kuze, Y. Okajima, M. Tanaka, T. Yoshida, M. Inomoto, M. Ishitsuka, H. Ito, R. Matsumoto, K. Ohta, M. Shinoki, J.F. Martin, C.M. Nantais, H.A. Tanaka, T. Towstego, R. Akutsu, M. Hartz, A. Konaka, N.W. Prouse, S. Chen, B.D. Xu, Y. Zhang, S. Berkman, S. Tobayama, K. Connolly, R.J. Wilkes, M. Posiadala-Zezula, D. Hadley, B. Richards, B. Jamieson, J. Walker, Ll. Marti, A. Minamino, G. Pintaudi, S. Sano, R. Sasaki, Abe, K., Haga, Y., Hayato, Y., Hiraide, K., Ieki, K., Ikeda, M., Imaizumi, S., Iyogi, K., Kameda, J., Kanemura, Y., Kataoka, Y., Kato, Y., Kishimoto, Y., Miki, S., Mine, S., Miura, M., Mochizuki, T., Moriyama, S., Nagao, Y., Nakahata, M., Nakajima, T., Nakano, Y., Nakayama, S., Okada, T., Okamoto, K., Orii, A., Sato, K., Sekiya, H., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Tasaka, S., Tomura, T., Ueno, K., Watanabe, S., Yano, T., Yokozawa, T., Han, S., Irvine, T., Kajita, T., Kametani, I., Kaneyuki, K., Lee, K. P., Mclachlan, T., Okumura, K., Richard, E., Tashiro, T., Wang, R., Xia, J., Megias, G. D., Bravo-Bergu??o, D., Labarga, L., Zaldivar, B., Goldhaber, M., Blaszczyk, F. d. M., Gustafson, J., Kachulis, C., Kearns, E., Raaf, J. L., Stone, J. L., Sulak, L. R., Sussman, S., Wan, L., Wester, T., Pointon, B. W., Bian, J., Carminati, G., Elnimr, M., Griskevich, N. J., Kropp, W. R., Locke, S., Renshaw, A., Smy, M. B., Sobel, H. W., Takhistov, V., Weatherly, P., Ganezer, K. S., Hartfiel, B. L., Hill, J., Keig, W. E., Hong, N., Kim, J. Y., Lim, I. T., Park, R. G., Akiri, T., Bodur, B., Himmel, A., Li, Z., O'Sullivan, E., Scholberg, K., Walter, C. W., Wongjirad, T., Bernard, L., Coffani, A., Drapier, O., El Hedri, S., Giampaolo, A., Imber, J., Mueller, Th. A., Paganini, P., Quilain, B., Ishizuka, T., Nakamura, T., Jang, J. S., Choi, K., Learned, J. G., Matsuno, S., Smith, S. N., Amey, J., Anthony, L. H. V., Litchfield, R. P., Ma, W. Y., Marin, D., Sztuc, A. A., Uchida, Y., Wascko, M. O., Berardi, V., Catanesi, M. G., Intonti, R. A., Radicioni, E., Calabria, N. F., De Rosa, G., Nascimento Machado, L., Collazuol, G., Iacob, F., Lamoureux, M., Ospina, N., Ludovici, L., Gonin, M., Pronost, G., Maekawa, Y., Nishimura, Y., Cao, S., Friend, M., Hasegawa, T., Ishida, T., Ishii, T., Jakkapu, M., Kobayashi, T., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Boschi, T., Di Lodovico, F., Migenda, J., Molina Sedgwick, S., Taani, M., Zsoldos, S., Abe, K. E., Hasegawa, M., Isobe, Y., Kotsar, Y., Miyabe, H., Ozaki, H., Shiozawa, T., Sugimoto, T., Suzuki, A. T., Takeuchi, Y., Yamamoto, S., Ali, A., Ashida, Y., Bronner, C., Feng, J., Hayashino, T., Hiraki, T., Hirota, S., Huang, K., Jiang, M., Kikawa, T., Mori, M., Murakami, A., Nakamura, Ke., Nakaya, T., Patel, N. D., Suzuki, K., Takahashi, S., Tateishi, K., Wendell, R. A., Yasutome, K., Fernandez, P., Mccauley, N., Mehta, P., Pritchard, A., Tsui, K. M., Fukuda, Y., Itow, Y., Menjo, H., Mitsuka, G., Murase, M., Muto, F., Niwa, T., Suzuki, T., Tsukada, M., Frankiewicz, K., Mijakowski, P., Hignight, J., Jiang, J., Jung, C. K., Li, X., Palomino, J. L., Santucci, G., Vilela, C., Wilking, M. J., Yanagisawa, C., Fukuda, D., Hagiwara, K., Harada, M., Horai, T., Ishino, H., Ito, S., Kayano, T., Kibayashi, A., Kitagawa, H., Koshio, Y., Ma, W., Mori, T., Nagata, H., Piplani, N., Sakai, S., Sakuda, M., Takahira, Y., Xu, C., Yamaguchi, R., Kuno, Y., Barr, G., Barrow, D., Cook, L., Goldsack, A., Samani, S., Simpson, C., Wark, D., Nova, F., Tacik, R., Yang, J. Y., Cole, A., Jenkins, S. J., Malek, M., Mcelwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Okazawa, H., Choi, Y., Kim, S. B., Yu, I., Ichikawa, A. K., Ito, K., Nishijima, K., Calland, R. G., de Perio, P., Martens, K., Murdoch, M., Vagins, M. R., Koshiba, M., Totsuka, Y., Iwamoto, K., Nakajima, Y., Ogawa, N., Suda, Y., Yokoyama, M., Hamabe, D., Izumiyama, S., Kuze, M., Okajima, Y., Tanaka, M., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Matsumoto, R., Ohta, K., Shinoki, M., Martin, J. F., Nantais, C. M., Tanaka, H. A., Towstego, T., Akutsu, R., Hartz, M., Konaka, A., Prouse, N. W., Chen, S., Xu, B. D., Zhang, Y., Berkman, S., Tobayama, S., Connolly, K., Wilkes, R. J., Posiadala-Zezula, M., Hadley, D., Richards, B., Jamieson, B., Walker, J., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., and Sasaki, R.

Subjects
Physics - Instrumentation and Detectors, Large detector systems for particle and astroparticle physics, hep-ex, Cherenkov detectors, FOS: Physical sciences, Acceleratorfysik och instrumentering, Instrumentation and Detectors (physics.ins-det), Accelerator Physics and Instrumentation, High Energy Physics - Experiment, Subatomär fysik, High Energy Physics - Experiment (hep-ex), Particle identification methods, Neutrino detectors, Subatomic Physics, Cherenkov detectors Large detector systems for particle and astroparticle physics Neutrino detectors Particle identification methods, Detectors and Experimental Techniques, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), physics.ins-det, Mathematical Physics, Particle Physics - Experiment, astro-ph.IM
Abstract

We present the development of neutron-tagging techniques in Super-Kamiokande IV using a neural network analysis. The detection efficiency of neutron capture on hydrogen is estimated to be 26%, with a mis-tag rate of 0.016 per neutrino event. The uncertainty of the tagging efficiency is estimated to be 9.0%. Measurement of the tagging efficiency with data from an Americium-Beryllium calibration agrees with this value within 10%. The tagging procedure was performed on 3,244.4 days of SK-IV atmospheric neutrino data, identifying 18,091 neutrons in 26,473 neutrino events. The fitted neutron capture lifetime was measured as 218±9 μs. We present the development of neutron-tagging techniques in Super-Kamiokande IV using a neural network analysis. The detection efficiency of neutron capture on hydrogen is estimated to be 26%, with a mis-tag rate of 0.016 per neutrino event. The uncertainty of the tagging efficiency is estimated to be 9.0%. Measurement of the tagging efficiency with data from an Americium-Beryllium calibration agrees with this value within 10%. The tagging procedure was performed on 3,244.4 days of SK-IV atmospheric neutrino data, identifying 18,091 neutrons in 26,473 neutrino events. The fitted neutron capture lifetime was measured as 218 \pm 9 \mu s.

Published
2022

11. P723 Comparison of the Persistence Rates of Biologic Agents in Paediatric Crohn's Disease Patients (Japanese Paediatric IBD Registry Study)

Author

D Nishida, T Ishige, K Arai, H Shimizu, I Iwama, R Nambu, R Kunisaki, K Yaguchi, T Mizuochi, T Murakoshi, T Saito, S Kato, T Kudo, N Iwata, M Inoue, T Yodoshi, S I Hagiwara, N Toita, H Tajiri, T Mochizuki, F Kakuta, H Kumagai, A Noguchi, M Sasaki, S Nishimata, T Aomatsu, Y Hirano, and T Shimizu

Subjects
Gastroenterology, General Medicine
Abstract

Background Biologics are widely used for paediatric Crohn's disease (CD) and are highly effective; however, primary inefficacy and the emergence of secondary inefficacy during long-term use remain challenges. Although it is desirable for biologics used in paediatric patients to be safe and usable long-term, there are few detailed reports on the comparison of persistence rates of biologics in paediatric patients. Methods This was a multicentre prospective cohort study using a web-based registry system in Japan that was performed between October 2012 and March 2020. New paediatric inflammatory bowel disease patients diagnosed at less than 18 years of age were enrolled from 23 Japanese hospitals. The persistence rates of the first biologics (Infliximab: IFX and Adalimumab: ADA), and the second biologics (IFX, ADA, and Ustekinumab: UST) were analysed. Patients with unknown outcomes were excluded. Results We enrolled 185 patients with CD as the final diagnosis, and 109 (59%) received biologics during the observation period. As the first biologic, IFX was used in 52 (45%) patients, ADA in 52 (45%), UST and Vedolizumab (VED) in one, respectively, and the biologic in one patient was unidentified. The 1-, 3- and 5-year persistence rates of IFX and ADA as the first biologic were 90%, 70% and 61% for IFX, and 80%, 71% and 49% for ADA, respectively (Fig.1), with no statistically significant difference (P=0.31). There was also no statistically significant difference after propensity score matching (P=0.27). Multivariate analysis showed that Paris classification L4a and b were independent risk factors for lower retention of biologics in IFX and ADA. Of the 104 patients whose first biologic was IFX or ADA, 31 patients were treated with a second biologic (IFX: 7, ADA: 6, UST: 15, VED: 2 and unknown: 1). The 1- and 3-year persistence rates of the second biologic were 86% and 51% for IFX; 80% and 80% for ADA and 100% and 100% for UST, respectively (Fig.2). Conclusion The persistence rates of IFX and ADA as first biologics were similar in paediatric patients with CD, and the persistence rates of UST tended to be higher than IFX or ADA as second biologics, although the differences were not statistically significant.

Published
2023
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12. Search for tens of MeV neutrinos associated with gamma-ray bursts in Super-Kamiokande

Author

P. Fernandez, Y. Nishimura, M. Inomoto, J. Bian, P. de Perio, G. Pronost, L. Wan, M. Lamoureux, Shintaro Ito, S. Zsoldos, Y. Takeuchi, K. Martens, J. Xia, Y. Sonoda, O. Drapier, Takatomi Yano, S. El Hedri, T. Shiozawa, Ahmed Ali, Ll. Marti, K. Nakamura, C. Xu, Hiroaki Menjo, C. Bronner, A. Konaka, T. Sekiguchi, K. S. Ganezer, M. Hartz, A. Giampaolo, B. Jamieson, N. F. Calabria, J. G. Learned, Takaaki Kajita, K. Yasutome, S. Nakayama, A. Takenaka, M. Harada, Vincenzo Berardi, William R. Kropp, S. Chen, R. G. Park, L. Ludovici, Kimihiro Okumura, Yasuhiro Takemoto, K. M. Tsui, A. Takeda, Hiromasa Tanaka, C. W. Walter, H. Okazawa, K. Okamoto, Y. Ashida, J. McElwee, S. Izumiyama, D. Barrow, Y. Fukuda, M. Ikeda, R. P. Litchfield, T. Okada, Intae Yu, N. Ogawa, Kate Scholberg, H. Miyabe, G. D. Megias, C. Simpson, Makoto Sakuda, L. Bernard, S. Samani, M. G. Catanesi, J. Y. Yang, Masaki Ishitsuka, M. Thiesse, F. d. M. Blaszczyk, Jl Stone, Yoshitaka Kuno, G. Pintaudi, K. Ohta, Hiroyuki Sekiya, F. Nova, Y. Kato, P. Weatherly, K. Abe, S. Han, T. Sugimoto, Hirokazu Ishino, Masayuki Nakahata, N. McCauley, C. M. Nantais, B. Zaldivar, T. Nakadaira, S. Sakai, E. Kearns, A. Goldsack, Michael B. Smy, M. Jakkapu, R. A. Wendell, Y. Uchida, M. Posiadala-Zezula, Y. Oyama, B. Bodur, C. Vilela, G. De Rosa, K. Sato, G. Collazuol, Luis Labarga, J. Kameda, J. Feng, D. Fukuda, T. Niwa, P. Mijakowski, P. Paganini, B. D. Xu, N. J. Griskevich, P. Mehta, T. Horai, C. K. Jung, Lester D.R. Thompson, Yusuke Koshio, D. Bravo-Berguño, S. Matsuno, T. Tsukamoto, K. Hagiwara, S. Hirota, M. Koshiba, Y. Nakajima, G.D. Barr, Yuuki Nakano, T. Mochizuki, Stephen J. Jenkins, I. T. Lim, T. Ishida, Y. Isobe, L. N. Machado, T. Boschi, John Walker, Th. A. Mueller, Hiroshi Ito, B. W. Pointon, M. Taani, R. Akutsu, A. A. Sztuc, Makoto Hasegawa, L. H. V. Anthony, Tatsuya Kikawa, Volodymyr Takhistov, Yousuke Kataoka, N. W. Prouse, S. V. Cao, A. Pritchard, M. Tsukada, M. Gonin, Yoshihiro Suzuki, Y. Nagao, A. Minamino, M. Shinoki, M. Malek, J. Y. Kim, J. L. Raaf, S. Yamamoto, T. Nakamura, S. Locke, M. Jiang, A. Coffani, Yasuhiro Kishimoto, O. Stone, Takashi Kobayashi, T. Towstego, T. Hasegawa, S. Mine, Takahiko Matsubara, K. Frankiewicz, N. Piplani, A. Orii, Mark R. Vagins, S. B. Kim, A. K. Ichikawa, K. E. Nakamura, S. Molina Sedgwick, B. Richards, Ken Sakashita, W. Ma, R. Matsumoto, B. Quilain, J. F. Martin, M. Friend, Masato Shiozawa, Y. Choi, L. Cook, A. Suzuki, Masashi Yokoyama, T. Ishizuka, Tsuyoshi Nakaya, J. S. Jang, Masahiro Kuze, R. Sasaki, Henry W. Sobel, Kyoshi Nishijima, Natalv Ospina, Shigetaka Moriyama, H. A. Tanaka, S. Imaizumi, K. Iwamoto, T. Tashiro, Manabu Tanaka, Yoshinari Hayato, C. Yanagisawa, T. Wester, Yoshitaka Itow, M. Miura, M. J. Wilking, Takashi Yoshida, F. Iacob, E. Radicioni, John Hill, D. L. Wark, Y. Takahira, R. Wang, M. Mori, F. Di Lodovico, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Super-Kamiokande, and Super-Kamiokande Collaboration

Subjects
Astrophysics::High Energy Astrophysical Phenomena, General Physics and Astronomy, FOS: Physical sciences, Astrophysics, KAMIOKANDE, gamma ray: burst, 01 natural sciences, Fluence, Coincidence, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Positron, F03 Ultra-high energy phenomena of cosmic rays, neutrino: energy, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], 010303 astronomy & astrophysics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, background, High Energy Physics::Phenomenology, F22 Neutrinos from supernova remnant and other astronomical objects, network, positron, High Energy Physics::Experiment, C43 Underground experiments, Underground experiments Ultra-high energy phenomena of cosmic rays Neutrinos from supernova remnant and other astronomical objects, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Super-Kamiokande, Gamma-ray burst, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Energy (signal processing), Bar (unit)
Abstract

A search for neutrinos produced in coincidence with Gamma-Ray Bursts(GRB) was conducted with the Super-Kamiokande (SK) detector. Between December 2008 and March 2017, the Gamma-ray Coordinates Network recorded 2208 GRBs that occurred during normal SK operation. Several time windows around each GRB were used to search for coincident neutrino events. No statistically significant signal in excess of the estimated backgrounds was detected. The $\bar\nu_e$ fluence in the range from 8 MeV to 100 MeV in positron total energy for $\bar\nu_e+p\rightarrow e^{+}+n$ was found to be less than $\rm 5.07\times10^5$ cm$^{-2}$ per GRB in 90\% C.L. Upper bounds on the fluence as a function of neutrino energy were also obtained., Comment: 29 pages, 16 figures, 5 tables, accepted by PTEP

Published
2021
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13. Search for proton decay via p→e+π0 and p→μ+π0 with an enlarged fiducial volume in Super-Kamiokande I-IV

Author

J. S. Jang, B. Bodur, Yuji Kishimoto, L. H. V. Anthony, Rongkun Wang, J. L. Raaf, L. Labarga, K. Nakamura, T. Niwa, T. Kobayashi, F. d. M. Blaszczyk, M. Jakkapu, M. Hartz, Y. Nishimura, P. Weatherly, S. Moriyama, Y. Isobe, T. Boschi, Hiroshi Ito, B. Richards, G. Santucci, Masayuki Nakahata, N. Ospina, Y. Uchida, V. Takhistov, C. K. Jung, M. Mori, M. Taani, Y. Sonoda, M. Ikeda, M. Koshiba, P. de Perio, T. Yano, A. T. Suzuki, K. Okamoto, J. F. Martin, Masato Shiozawa, Y. Choi, Yoshitaka Itow, H. Okazawa, G. Pintaudi, E. Radicioni, L. Ludovici, W. R. Kropp, K. Sakashita, Yutaka Nakajima, C. Xu, Hiroaki Menjo, P. Paganini, M. Miura, T. Nakadaira, G. Pronost, F. Iacob, R. G. Park, B. D. Xu, N. F. Calabria, O. Drapier, Makoto Sakuda, Ke. Nakamura, M. Jiang, A. Coffani, M. Posiadala-Zezula, T. Horai, Ko Okumura, H. W. Sobel, S. Matsuno, A. Giampaolo, S. Molina Sedgwick, Yuuki Nakano, T. Mochizuki, T. Tashiro, T. Towstego, S. Imaizumi, K. Hagiwara, H.A. Tanaka, S. Cao, S. Sakai, B. W. Pointon, F. Nova, R. Sasaki, R. Matsumoto, Intae Yu, P. Mehta, Y. Kataoka, D. Fukuda, C. Bronner, M. G. Catanesi, S. Han, Pablo Fernandez, H. Miyabe, M. J. Wilking, Yuichi Oyama, R. P. Litchfield, C. M. Nantais, D. Bravo-Berguño, B. Quilain, J. G. Learned, K. Yasutome, S. Zsoldos, Y. Kuno, Ke. Abe, K. Nishijima, S. Locke, Atsushi Takeda, J. C. Hill, K. Ohta, T. Wester, E. Kearns, Vincenzo Berardi, N. Piplani, G. De Rosa, Masashi Yokoyama, J. L. Stone, David A. Wark, J. Y. Yang, M. Tsukada, Y. Takahira, Masaki Ishitsuka, M. Thiesse, K. Iwamoto, G.D. Barr, A. Konaka, S. J. Jenkins, M. R. Vagins, J. Walker, N. J. Griskevich, A. Ali, Yusuke Koshio, Y. Takemoto, A. Pritchard, W. Y. Ma, D. Barrow, L. F. Thompson, T. Ishizuka, Makoto Hasegawa, Y. Nagao, J. McElwee, A. Minamino, Tsuyoshi Nakaya, B. Jamieson, M. Shinoki, K. Frankiewicz, N. McCauley, S. B. Kim, I. T. Lim, S. Yamamoto, T. Matsubara, J. Y. Kim, A. Orii, S. El Hedri, J. Feng, L. Cook, Y. Takeuchi, T. Kajita, J. Bian, H. K. Tanaka, Seiko Hirota, T. Kikawa, M. Gonin, J. Xia, M. Friend, Masaaki Tanaka, N. W. Prouse, C. W. Walter, T. Sugimoto, Hiroyuki Sekiya, Y. Fukuda, L. Wan, R. Akutsu, Y. Hayato, T. Sekiguchi, Yasunari Suzuki, T. Shiozawa, C. Vilela, Ll. Marti, T. Yoshida, Song Chen, K. S. Ganezer, Yuto Ashida, T. Tsukamoto, T. Okada, T. Nakamura, N. Ogawa, T. Ishida, C. Yanagisawa, A. Goldsack, S. Nakayama, R. A. Wendell, A. Takenaka, K. Sato, A. K. Ichikawa, J. Kameda, Th. A. Mueller, Shintaro Ito, P. Mijakowski, Kalen Martens, Kate Scholberg, S. Mine, K. M. Tsui, Takehisa Hasegawa, M. Lamoureux, Hirokazu Ishino, Chris Simpson, G. Collazuol, F. Di Lodovico, M. Kuze, M. Inomoto, A. A. Sztuc, M. B. Smy, B. Zaldivar, Yuta Kato, L. N. Machado, and M. Harada

Subjects
Physics, 010308 nuclear & particles physics, Proton decay, Detector, 01 natural sciences, Lower limit, Nuclear physics, Volume (thermodynamics), 0103 physical sciences, Pi, Atmospheric neutrino, 010306 general physics, Fiducial marker, Super-Kamiokande
Abstract

We have searched for proton decay via p→e+π0 and p→μ+π0 modes with the enlarged fiducial volume data of Super-Kamiokande from April 1996 to May 2018, which corresponds to 450 kton·years exposure. We have accumulated about 25% more livetime and enlarged the fiducial volume of the Super-Kamiokande detector from 22.5 kton to 27.2 kton for this analysis, so that 144 kton·years of data, including 78 kton·years of additional fiducial volume data, has been newly analyzed. No candidates have been found for p→e+π0 and one candidate remains for p→μ+π0 in the conventional 22.5 kton fiducial volume and it is consistent with the atmospheric neutrino background prediction. We set lower limits on the partial lifetime for each of these modes: τ/B(p→e+π0)>2.4×1034 years and τ/B(p→μ+π0)>1.6×1034 years at 90% confidence level.

Published
2020
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15. ‘Yotsuboshi’, a new F1 hybrid strawberry of seed propagation type for year-round production

Author

F. Maeda, T. Inokuchi, I. Kato, Sachiko Isobe, J. Kohori, H. Kitamura, K. Sone, M. Ishikawa, Masanobu Fukami, Shusei Sato, T. Mori, and T. Mochizuki

Subjects
Breeding program, business.industry, Crop yield, media_common.quotation_subject, food and beverages, Horticulture, Biology, High yielding, Adaptability, Agriculture, Production (economics), Cultivar, Sugar, business, media_common
Abstract

'Yotsuboshi', a seed propagating type F1 hybrid strawberry cultivar adaptable for year-round production, was developed from the collaborative breeding program including four institutes of Mie, Kagawa and Chiba prefectures and National Agriculture and Food Research Organization (NARO) in Japan. The behavior of flower initiation is quite unique. 'otuboshi' exhibits stable extra earliness under natural condition with a lower temperature and shorter day-length, while it possesses the ever-bearing gene which results in the induction of flower initiation under long-day condition. Thus 'Yotsuboshi' is adaptable for year-round production including both forcing culture in autumn to spring and summer-autumn cultivation across Japan. 'Yotsuboshi' has several attractive traits such as a clear red fruit color, excellent fruit shape and size, high yielding ability, and superior taste with a high content of sugar and moderate acidity. The practical production system of F1 hybrid seeds and the DNA marker system for certifying the uniformity of seeds have already been established. The seeds and/or plug tray seedlings will be commercially provided from this summer for the member of the 'Research society for seed propagating type strawberries in Japan'.

Published
2017
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17. Measurement of the neutrino-oxygen neutral-current quasielastic cross section using atmospheric neutrinos at Super-Kamiokande

Author

E. Kearns, Masashi Yokoyama, T. Sugimoto, T. Towstego, T. Ishizuka, Y. Hayato, Tsuyoshi Nakaya, R. Akutsu, L. H. V. Anthony, C. W. Walter, F. Di Lodovico, C. Kachulis, T. Hayashino, C. K. Jung, Y. Kuno, K. Nishijima, A. Konaka, A. Minamino, N. McCauley, C. M. Nantais, Masato Shiozawa, Y. Choi, L. Ludovici, N. J. Griskevich, M. Vagins, M. Kuze, J. L. Raaf, Yusuke Koshio, Atsushi Takeda, T. Sekiguchi, P. de Perio, B. Bodur, V. Takhistov, Hiroyuki Sekiya, S. Molina Sedgwick, Soo-Bong Kim, Y. Fukuda, L. Wan, N. F. Calabria, Ke. Nakamura, Hirokazu Ishino, Y. Isobe, Y. Takeuchi, Lester D.R. Thompson, K. Martens, Y. Nishimura, A. T. Suzuki, K. Okamoto, Hiromasa Tanaka, M. Murdoch, J. Bian, C. Vilela, T. Tsukamoto, T. Okada, C. Xu, A. Pritchard, Makoto Hasegawa, W. R. Kropp, K. Sakashita, J. F. Martin, Takaaki Kajita, Yuichi Oyama, T. Nakadaira, M. Friend, M. Thiesse, G. De Rosa, C. Simpson, J. Imber, K. M. Tsui, Ahmed Ali, M. B. Smy, R. P. Litchfield, Seiko Hirota, Xiao-yan Li, G. Collazuol, Yuta Kato, T. Ishida, Rongkun Wang, T. Kikawa, M. Gonin, J. Xia, H. K. Tanaka, M. G. Catanesi, M. Ikeda, Makoto Sakuda, M. Miura, K. Frankiewicz, Yutaka Nakajima, Ll. Marti, K. Abe, J. L. Stone, Y. Okajima, K. Iyogi, J. Y. Kim, S. Mine, A. Orii, S. Cao, L. Labarga, Yoshihiro Suzuki, R. A. Wendell, M. J. Wilking, S. Berkman, J. L. Palomino, M. Hartz, K. Choi, Pablo Fernandez, C. Bronner, Shintaro Ito, R. A. Intonti, J. G. Learned, I. T. Lim, H. Miyabe, Kate Scholberg, H. Okazawa, S. Locke, S. Matsuno, B. Quilain, A. Takenaka, F. d. M. Blaszczyk, P. Weatherly, B. Richards, M. Koshiba, R. G. Park, Ko Okumura, Ke. Abe, K. Hagiwara, Yuuki Nakano, T. Mochizuki, Sara Sussman, J. Kameda, Th. A. Mueller, P. Mijakowski, Felix Iacob, J. S. Jang, Masaki Ishitsuka, M. O. Wascko, A. Goldsack, S. Nakayama, T. Yoshida, Song Chen, R. Tacik, D. Fukuda, K. S. Ganezer, E. Radicioni, John Hill, D. L. Wark, Y. Takahira, T. Yano, M. Mori, Y. Sonoda, Yoshitaka Itow, G. Pronost, T. Nakamura, M. Murrase, C. Yanagisawa, H. W. Sobel, Y. Ashida, K. Nakamura, S. Moriyama, G. Santucci, Masayuki Nakahata, Y. Uchida, T. Hasegawa, M. Jiang, Yasuhiro Kishimoto, Takashi Kobayashi, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Super-Kamiokande, Science and Technology Facilities Council (STFC), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), DE ROSA, Gianfranca, and Et, Al

Subjects
Physics::Instrumentation and Detectors, neutrino oxygen neutral current interaction, Flux, KAMIOKANDE, 7. Clean energy, 01 natural sciences, neutrino: flux, High Energy Physics - Experiment, Physics, Particles & Fields, High Energy Physics - Experiment (hep-ex), neutrino: atmosphere, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Particle Physics Experiments, neutrino: supernova, Nuclear Experiment, Physics, neutrino nucleon: inelastic scattering, atmospheric neutrinos, Supernova, Physical Sciences, quasi-elastic cross section, Neutrino, Nucleon, channel cross section: measured, neutrino oxygen neutral current interaction, quasi-elastic cross section, atmospheric neutrinos, SuperKamiokande experiment, neutral current, Cherenkov counter: water, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astronomy & Astrophysics, EVENTS, Nuclear physics, 5/3, neutrino: spectrum, SEARCH, 0103 physical sciences, 010306 general physics, Cherenkov radiation, Science & Technology, Neutral current, background, 010308 nuclear & particles physics, Scattering, scattering, neutrino nucleus: interaction, MU, 13. Climate action, High Energy Physics::Experiment, Super-Kamiokande, oxygen, SuperKamiokande experiment, experimental results
Abstract

Neutral current (NC) interactions of atmospheric neutrinos on oxygen form one of the major backgrounds in the search for supernova relic neutrinos with water-based Cherenkov detectors. The NC channel is dominated by neutrino quasi-elastic (NCQE) scattering off nucleons inside $^{16}$O nuclei. In this paper we report the first measurement of NCQE cross section using atmospheric neutrinos at Super-Kamiokande (SK). The measurement used 2,778 live days of SK-IV data with a fiducial volume of 22.5 kiloton water. Within the visible energy window of 7.5-29.5 MeV, we observed $117$ events compared to the expected $71.9$ NCQE signal and $53.1$ background events. Weighted by the atmospheric neutrino spectrum from 160 MeV to 10 GeV, the flux averaged NCQE cross section is measured to be $(1.01\pm0.17(\text{stat.})^{+0.78}_{-0.30}(\text{sys.}))\times10^{-38}$ cm$^2$., Comment: 11 pages, 9 figures, submitted to PRD

Published
2019
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19. Effect of augmented datasets on deep convolutional neural networks applied to chest radiographs

Author

R. Ogawa, T. Kido, and T. Mochizuki

Subjects
Abnormal chest, Radiography, Gaussian blur, Convolutional neural network, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Retrospective Studies, Contextual image classification, business.industry, Pattern recognition, General Medicine, Binary classification, 030220 oncology & carcinogenesis, Test set, symbols, Radiographic Image Interpretation, Computer-Assisted, Radiography, Thoracic, Artificial intelligence, Neural Networks, Computer, business, Rotation (mathematics)
Abstract

AIM To evaluate the effect of augmented training datasets in a deep convolutional neural network (DCNN) used for detecting abnormal chest radiographs. MATERIALS AND METHODS Chest radiographs were corrected to conform to a DCNN dataset, with 288 abnormal and 447 normal radiographs. The radiographic images were divided into training and validation sets (441, 60%), and a test set (294, 40%). The training and validation sets were augmented to generate a total of 12,789 training and validation images. The augmentation consisted of operations such as rotation, horizontal and vertical flipping, Gaussian blur, and brightness variation, either alone or combined. The DCNN performed binary classification of the images as being abnormal or normal chest radiographs, and accuracy was used as measure to assess the model performance. RESULTS The accuracy of the DCNN trained with the augmented dataset tended to be higher than that of the DCNN trained with the non-augmented dataset. The augmented datasets combining rotation and horizontal flipping had a high accuracy of 0.91, showing the highest accuracy among the applied augmentation techniques and combinations. CONCLUSION Augmentation of training datasets can improve the performance of DCNN for radiographic image classification depending on the applied augmentation technique.

Published
2018

20. Preoperative neutrophil-to-lymphocyte ratio as a prognosticator in early stage pancreatic ductal adenocarcinoma

Author

T. Mochizuki, Toshio Noriyuki, Masahiro Nakahara, Takuya Yano, Nobuaki Fujikuni, Tomoyuki Abe, Tomoaki Bekki, H. Takechi, H. Amano, and Hiroshi Okuda

Subjects
Pathology, medicine.medical_specialty, Pancreatic ductal adenocarcinoma, Hepatology, business.industry, Gastroenterology, medicine, Stage (cooking), Neutrophil to lymphocyte ratio, business
Published
2018
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21. Preoperative ratio of visceral adipose tissue area to skeletal mass index as a risk factor for pancreatic fistula following pancreatectomy

Author

Tomoyuki Abe, H. Amano, T. Mochizuki, Masahiro Nakahara, H. Takechi, Nobuaki Fujikuni, Tomoaki Bekki, Takuya Yano, Toshio Noriyuki, and Hiroshi Okuda

Subjects
medicine.medical_specialty, Hepatology, business.industry, medicine.medical_treatment, Gastroenterology, Adipose tissue, medicine.disease, Pancreatic fistula, Internal medicine, Pancreatectomy, medicine, Mass index, Risk factor, business
Published
2018
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22. Diagnostic capability of feature-tracking cardiovascular magnetic resonance to detect infarcted segments: a comparison with tagged magnetic resonance and wall thickening analysis

Author

R. Ogawa, T. Kido, M. Nakamura, A. Kurata, M. Miyagawa, and T. Mochizuki

Subjects
Male, Myocardial Infarction, 030204 cardiovascular system & hematology, Sensitivity and Specificity, 030218 nuclear medicine & medical imaging, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, medicine, Circumferential strain, Late gadolinium enhancement, Humans, Radiology, Nuclear Medicine and imaging, In patient, cardiovascular diseases, Myocardial infarction, Aged, Retrospective Studies, medicine.diagnostic_test, business.industry, Myocardium, Reproducibility of Results, Magnetic resonance imaging, Heart, General Medicine, Middle Aged, medicine.disease, Magnetic Resonance Imaging, cardiovascular system, Feature tracking, Female, Thickening, business, Nuclear medicine
Abstract

To examine the diagnostic capabilities of feature-tracking cardiovascular magnetic resonance (FT-CMR), tagged cine magnetic resonance (MR), and wall thickening (WT) analyses to detect infarcted segments in patients with established myocardial infarction (MI).Twenty patients with established MI were selected retrospectively and the peak endocardial circumferential strain (CS) was quantified based on the 16-segment model. According to CMR with late gadolinium enhancement, segments were categorised as transmural MI, subendocardial MI, and no MI.A total of 320 segments (62 transmural MI, 50 subendocardial MI, and 208 no MI) were analysed. Peak endocardial CS was significantly lower for transmural MI compared with subendocardial MI (p0.05) and no MI (p0.001). Cut-off values of -11.2% for CS by FTCMR, -10.9% for CS by tagged MR, and 23.8% for %WT, differentiated between infarcted and non-infarcted segments with a sensitivity of 72%, 71%, and 56%; specificity of 71%, 75%, and 67%; accuracy of 72%, 73%, and 63%; positive predictive value of 57%, 60%, and 48%; negative predictive value of 83%, 83%, and 74%; and an area-under-the-curve of 0.77, 0.79, and 0.64, respectively.FT-CMR was diagnostically superior to %WT, and could differentiate between subendocardial and transmural MI. Unlike tagged MR, FT-CMR did not require the acquisition of additional sequences.

Published
2016

23. Renal development and cystic diseases

Author

C. Cabrera-Lopez, E. Ars, T. Marti, P. C. Harris, R. Torra, C. Clerckx, T. Migeon, Z. Chen, P. Ronco, E. Plaisier, I. J. Lamers, J. Van Reeuwijk, M. Azam, K. Boldt, M. Maria, L. Koster-Kamphuis, R. Qamar, M. Ueffing, F. P. Cremers, R. Roepman, H. H. Arts, S. Papizh, V. Dlin, I. Leontieva, K. Tutelman, R. D. Perrone, K. T. Bae, A. B. Chapman, O. Devuyst, R. T. Gansevoort, J. J. Grantham, E. Higashihara, V. E. Torres, O. Sergeyeva, W. Zhou, J. D. Blais, F. S. Czerwiec, F. Liu, Y. Liao, P. Fu, N. Casteleijn, D. Zittema, S. Bakker, W. Boertien, C. Gaillard, E. Meijer, E. Spithoven, J. Struck, R. Gansevoort, P. Robinson, P. McEwan, H. Hadimeri, A. C. M. Ong, B. Orskov, R. Peces, R. Sandford, F. Scolari, G. Walz, C. Cooke, K. O'Reilly, M. Riwanto, S. Kapoor, D. Rodriguez, I. Edenhofer, S. Segerer, R. P. Wuthrich, S. De Rechter, J. Bacchetta, M. Van Dyck, P. Evenepoel, J. De Schepper, E. Levtchenko, D. Mekahli, A. Carr, A. Makin, A. Baker, L. Obeidova, J. Stekrova, T. Seeman, A. Puchmajerova, J. Reiterova, M. Kohoutova, V. Tesar, S. Treille, J.-M. Bailly, B. Guillaume, L. Tuta, A. Stanigut, F. Botea, H. A. Jo, H. C. Park, H. Kim, M. Han, H. Huh, J. C. Jeong, K.-H. Oh, J. Yang, T. Y. Koo, Y.-H. Hwang, C. Ahn, A. Pisani, G. Remuzzi, P. Ruggenenti, E. Riccio, B. Visciano, L. Spinelli, J. I. Kim, K. M. Park, F. X. Liu, P. Rutherford, K. Smoyer-Tomic, V. Martinez Jimenez, J. Comas, E. Arcos, J. M. Diaz, S. Muray, J. Cabezuelo, J. Ballarin, T. Miyaoka, S. Morimoto, H. Kataoka, T. Mochizuki, K. Tsuchiya, A. Ichihara, and K. Nitta

Subjects
Cystic diseases, Transplantation, medicine.medical_specialty, Nephrology, business.industry, Medicine, business, Intensive care medicine
Published
2016

25. Crystal structure and X-ray diffraction data of a new hexagonal perovskite compound, Ba4CuNb3O12

Author

Nobukazu Kinomura, W. Zhang, Yoshinori Yonesaki, N. Kumada, Qiang Dong, Takahiro Takei, and T. Mochizuki

Subjects
Radiation, Materials science, Hexagonal crystal system, chemistry.chemical_element, Barium, Crystal structure, Condensed Matter Physics, Copper, Crystallography, chemistry, X-ray crystallography, General Materials Science, Inert gas, Instrumentation, Chemical composition, Perovskite (structure)
Abstract

A new barium copper niobate, Ba4CuNb3O12, was successfully prepared by high-temperature solid-state reaction in an inert atmosphere. Rietveld-refinement analysis of the XRD data of the compound showed that it has the 8H-type hexagonal perovskite structure with space group P63/mmc (#194), a = 5.830(1) Å, c = 19.123(1) Å, and chemical composition of Ba4Cu1.84Nb2.16O12-δ.

Published
2011
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26. Abstracts

Author

V. Dunet, A. Dabiri, G. Allenbach, A. Goyeneche Achigar, B. Waeber, F. Feihl, R. Heinzer, J. O. Prior, J. E. Van Velzen, J. D. Schuijf, F. R. De Graaf, M. A. De Graaf, M. J. Schalij, L. J. Kroft, A. De Roos, J. W. Jukema, E. E. Van Der Wall, J. J. Bax, E. Lankinen, A. Saraste, T. Noponen, R. Klen, M. Teras, T. Kokki, S. Kajander, M. Pietila, H. Ukkonen, J. Knuuti, A. P. Pazhenkottil, R. N. Nkoulou, J. R. Ghadri, B. A. Herzog, R. R. Buechel, S. M. Kuest, M. Wolfrum, O. Gaemperli, L. Husmann, P. A. Kaufmann, D. Andreini, G. Pontone, S. Mushtaq, L. Antonioli, E. Bertella, A. Formenti, S. Cortinovis, G. Ballerini, C. Fiorentini, M. Pepi, A. S. Koh, J. S. Flores, F. Y. J. Keng, R. S. Tan, T. S. J. Chua, A. D. Annoni, G. Tamborini, M. Fusari, A. L. Bartorelli, S. H. Ewe, A. C. T. Ng, V. Delgado, J. Schuijf, F. Van Der Kley, A. Colli, A. De Weger, N. A. Marsan, K. H. Yiu, A. C. Ng, S. A. J. Timmer, P. Knaapen, T. Germans, P. A. Dijkmans, M. Lubberink, J. M. Ten Berg, F. J. Ten Cate, I. K. Russel, A. A. Lammertsma, A. C. Van Rossum, Y. Y. Wong, G. Ruiter, P. Raijmakers, W. J. Van Der Laarse, N. Westerhof, A. Vonk-Noordegraaf, G. Youssef, E. Leung, G. Wisenberg, C. Marriot, K. Williams, J. Etele, R. A. Dekemp, J. Dasilva, D. Birnie, R. S. B. Beanlands, R. C. Thompson, A. H. Allam, L. S. Wann, A. H. Nureldin, G. Adelmaksoub, I. Badr, M. L. Sutherland, J. D. Sutherland, M. I. Miyamoto, G. S. Thomas, H. J. Harms, S. De Haan, M. C. Huisman, R. C. Schuit, A. D. Windhorst, C. Allaart, A. J. Einstein, T. Khawaja, C. Greer, A. Chokshi, M. Jones, K. Schaefle, K. Bhatia, D. Shimbo, P. C. Schulze, A. Srivastava, R. Chettiar, J. Moody, C. Weyman, D. Natale, W. Bruni, Y. Liu, E. Ficaro, A. J. Sinusas, A. Peix, E. Batista, L. O. Cabrera, K. Padron, L. Rodriguez, B. Sainz, V. Mendoza, R. Carrillo, Y. Fernandez, E. Mena, A. Naum, T. Bach-Gansmo, N. Kleven-Madsen, M. Biermann, B. Johnsen, J. Aase Husby, S. Rotevatn, J. E. Nordrehaug, J. Schaap, R. M. Kauling, M. C. Post, B. J. W. M. Rensing, J. F. Verzijlbergen, J. Sanchez, G. Giamouzis, N. Tziolas, P. Georgoulias, G. Karayannis, A. Chamaidi, N. Zavos, K. Koutrakis, G. Sitafidis, J. Skoularigis, F. Triposkiadis, S. Radovanovic, A. Djokovic, D. V. Simic, M. Krotin, A. Savic-Radojevic, M. Pljesa-Ercegovac, M. Zdravkovic, J. Saponjski, S. Jelic, T. Simic, R. Eckardt, B. J. Kjeldsen, L. I. Andersen, T. Haghfelt, P. Grupe, A. Johansen, B. Hesse, H. Pena, G. Cantinho, M. Wilk, Y. Srour, F. Godinho, N. Zafrir, A. Gutstein, I. Mats, A. Battler, A. Solodky, E. Sari, N. Singh, A. Vara, A. M. Peters, A. De Belder, S. Nair, N. Ryan, R. James, S. Dizdarevic, G. Depuey, M. Friedman, R. Wray, R. Old, H. Babla, B. Chuanyong, J. Maddahi, E. Tragardh Johansson, K. Sjostrand, L. Edenbrandt, S. Aguade-Bruix, G. Cuberas-Borros, M. N. Pizzi, M. Sabate-Fernandez, G. De Leon, D. Garcia-Dorado, J. Castell-Conesa, J. Candell-Riera, D. Casset-Senon, M. Edjlali-Goujon, D. Alison, A. Delhommais, P. Cosnay, C. S. Low, A. Notghi, J. O'brien, A. C. Tweddel, N. Bingham, P. O Neil, M. Harbinson, O. Lindner, W. Burchert, M. Schaefers, C. Marcassa, R. Campini, P. Calza, O. Zoccarato, A. Kisko, J. Kmec, M. Babcak, M. Vereb, M. Vytykacova, J. Cencarik, P. Gazdic, J. Stasko, A. Abreu, E. Pereira, L. Oliveira, P. Colarinha, V. Veloso, I. Enriksson, G. Proenca, P. Delgado, L. Rosario, J. Sequeira, I. Kosa, I. Vassanyi, C. S. Egyed, G. Y. Kozmann, S. Morita, M. Nanasato, I. Nanbu, Y. Yoshida, H. Hirayama, A. Allam, A. Sharef, I. Shawky, M. Farid, M. Mouden, J. P. Ottervanger, J. R. Timmer, M. J. De Boer, S. Reiffers, P. L. Jager, S. Knollema, G. M. Nasr, M. Mohy Eldin, M. Ragheb, I. Casans-Tormo, R. Diaz-Exposito, F. J. Hurtado-Mauricio, R. Ruano, M. Diego, F. Gomez-Caminero, C. Albarran, A. Martin De Arriba, A. Rosero, R. Lopez, C. Martin Luengo, J. R. Garcia-Talavera, I. E. K. Laitinen, M. Rudelius, E. Weidl, G. Henriksen, H. J. Wester, M. Schwaiger, X. B. Pan, T. Schindler, A. Quercioli, H. Zaidi, O. Ratib, J. M. Declerck, E. Alexanderson Rosas, R. Jacome, M. Jimenez-Santos, E. Romero, M. A. Pena-Cabral, A. Meave, J. Gonzalez, F. Rouzet, L. Bachelet, J. M. Alsac, M. Suzuki, L. Louedec, A. Petiet, F. Chaubet, D. Letourneur, J. B. Michel, D. Le Guludec, A. Aktas, A. Cinar, G. Yaman, T. Bahceci, K. Kavak, A. Gencoglu, A. Jimenez-Heffernan, E. Sanchez De Mora, J. Lopez-Martin, R. Lopez-Aguilar, C. Ramos, C. Salgado, A. Ortega, C. Sanchez-Gonzalez, J. Roa, A. Tobaruela, S. V. Nesterov, O. Turta, M. Maki, C. Han, D. Daou, M. Tawileh, S. O. Chamouine, C. Coaguila, E. Mariscal-Labrador, N. Kisiel-Gonzalez, P. De Araujo Goncalves, P. J. Sousa, H. Marques, J. O'neill, J. Pisco, R. Cale, J. Brito, A. Gaspar, F. P. Machado, J. Roquette, M. Martinez, G. Melendez, E. Kimura, J. M. Ochoa, A. M. Alessio, A. Patel, R. Lautamaki, F. M. Bengel, J. B. Bassingthwaighte, J. H. Caldwell, K. Rahbar, H. Seifarth, M. Schafers, L. Stegger, T. Spieker, A. Hoffmeier, D. Maintz, H. Scheld, O. Schober, M. Weckesser, H. Aoki, I. Matsunari, K. Kajinami, M. Martin Fernandez, M. Barreiro Perez, O. V. Fernandez Cimadevilla, D. Leon Duran, E. Velasco Alonso, J. P. Florez Munoz, L. H. Luyando, C. Templin, C. E. Veltman, J. H. C. Reiber, S. Venuraju, A. Yerramasu, S. Atwal, A. Lahiri, T. Kunimasa, M. Shiba, K. Ishii, J. Aikawa, E. S. J. Kroner, K. T. Ho, Q. W. Yong, K. C. Chua, C. Panknin, C. J. Roos, J. M. Van Werkhoven, A. J. Witkowska-Grzeslo, M. J. Boogers, D. V. Anand, D. Dey, D. Berman, F. Mut, R. Giubbini, L. Lusa, T. Massardo, A. Iskandrian, M. Dondi, A. Sato, Y. Kakefuda, E. Ojima, T. Adachi, A. Atsumi, T. Ishizu, Y. Seo, M. Hiroe, K. Aonuma, M. Kruk, R. Pracon, C. Kepka, J. Pregowski, A. Kowalewska, M. Pilka, M. Opolski, I. Michalowska, Z. Dzielinska, M. Demkow, V. Stoll, N. Sabharwal, A. Chakera, O. Ormerod, H. Fernandes, M. Bernardes, E. Martins, P. Oliveira, T. Vieira, G. Terroso, A. Oliveira, T. Faria, F. Ventura, J. Pereira, S. Fukuzawa, M. Inagaki, J. Sugioka, A. Ikeda, S. Okino, J. Maekawa, T. Uchiyama, N. Kamioka, S. Ichikawa, M. Afshar, R. Alvi, N. Aguilar, R. Ippili, H. Shaqra, J. Bella, N. Bhalodkar, A. Dos Santos, M. Daicz, L. O. Cendoya, H. G. Marrero, J. Casuscelli, M. Embon, G. Vera Janavel, E. Duronto, E. P. Gurfinkel, C. M. Cortes, Y. Takeishi, K. Nakajima, Y. Yamasaki, T. Nishimura, K. Hayes Brown, F. Collado, M. Alhaji, J. Green, S. Alexander, R. Vashistha, S. Jain, F. Aldaas, J. Shanes, R. Doukky, K. Ashikaga, Y. J. Akashi, M. Uemarsu, R. Kamijima, K. Yoneyama, K. Omiya, Y. Miyake, Y. Brodov, U. Raval, A. Berezin, V. Seden, E. Koretskaya, T. A. Panasenko, S. Matsuo, S. Kinuya, J. Chen, R. J. Van Bommel, B. Van Der Hiel, P. Dibbets-Schneider, E. V. Garcia, I. Rutten-Vermeltfoort, M. M. J. Gevers, B. Verhoeven, A. B. Dijk Van, E. Raaijmakers, P. G. H. M. Raijmakers, J. E. Engvall, M. Gjerde, J. De Geer, E. Olsson, P. Quick, A. Persson, M. Mazzanti, M. Marini, L. Pimpini, G. P. Perna, C. Marciano, P. Gargiulo, M. Galderisi, C. D'amore, G. Savarese, L. Casaretti, S. Paolillo, A. Cuocolo, P. Perrone Filardi, M. Al-Amoodi, E. C. Thompson, K. Kennedy, K. A. Bybee, A. I. Mcghie, J. H. O'keefe, T. M. Bateman, R. L. F. Van Der Palen, A. M. Mavinkurve-Groothuis, B. Bulten, L. Bellersen, H. W. M. Van Laarhoven, L. Kapusta, L. F. De Geus-Oei, P. P. Pollice, M. B. Bonifazi, F. P. Pollice, I. P. Clements, D. O. Hodge, C. G. Scott, M. De Ville De Goyet, B. Brichard, T. Pirotte, S. Moniotte, R. A. Tio, A. Elvan, R. A. I. O. Dierckx, R. H. J. A. Slart, T. Furuhashi, M. Moroi, H. Hase, N. Joki, H. Masai, R. Nakazato, H. Fukuda, K. Sugi, K. Kryczka, E. Kaczmarska, J. Petryka, L. Mazurkiewicz, W. Ruzyllo, P. Smanio, E. Vieira Segundo, M. Siqueira, J. Kelendjian, J. Ribeiro, J. Alaca, M. Oliveira, F. Alves, I. Peovska, J. Maksimovic, M. Vavlukis, N. Kostova, D. Pop Gorceva, V. Majstorov, M. Zdraveska, S. Hussain, M. Djearaman, E. Hoey, L. Morus, O. Erinfolami, A. Macnamara, M. P. Opolski, A. Witkowski, V. Berti, F. Ricci, R. Gallicchio, W. Acampa, G. Cerisano, C. Vigorito, R. Sciagra', A. Pupi, H. Sliem, F. M. Collado, S. Schmidt, A. Maheshwari, R. Kiriakos, V. Mwansa, S. Ljubojevic, S. Sedej, M. Holzer, G. Marsche, V. Marijanski, J. Kockskaemper, B. Pieske, A. Ricalde, G. Alexanderson, A. Mohani, P. Khanna, A. Sinusas, F. Lee, V. A. Pinas, B. L. F. Van Eck-Smit, H. J. Verberne, C. M. De Bruin, G. Guilhermina, L. Jimenez-Angeles, O. Ruiz De Jesus, O. Yanez-Suarez, E. Vallejo, E. Reyes, M. Chan, M. L. Hossen, S. R. Underwood, A. Karu, S. Bokhari, V. Pineda, L. M. Gracia-Sanchez, A. Garcia-Burillo, K. Zavadovskiy, Y. U. Lishmanov, W. Saushkin, I. Kovalev, A. Chernishov, A. Annoni, M. Tarkia, T. Saanijoki, V. Oikonen, T. Savunen, M. A. Green, M. Strandberg, A. Roivainen, M. C. Gaeta, C. Artigas, J. Deportos, L. Geraldo, A. Flotats, V. La Delfa, I. Carrio, W. J. Laarse, M. M. Izquierdo Gomez, J. Lacalzada Almeida, A. Barragan Acea, A. De La Rosa Hernandez, R. Juarez Prera, G. Blanco Palacios, J. A. Bonilla Arjona, J. J. Jimenez Rivera, J. L. Iribarren Sarrias, I. Laynez Cerdena, A. Dedic, A. Rossi, G. J. R. Ten Kate, A. Dharampal, A. Moelker, T. W. Galema, N. Mollet, P. J. De Feyter, K. Nieman, D. Trabattoni, A. Broersen, M. Frenay, M. M. Boogers, P. H. Kitslaar, J. Dijkstra, D. A. Annoni, M. Muratori, N. Johki, M. Tokue, A. S. Dharampal, A. C. Weustink, L. A. E. Neefjes, S. L. Papadopoulou, C. Chen, N. R. A. Mollet, E. H. Boersma, G. P. Krestin, J. A. Purvis, D. Sharma, S. M. Hughes, D. S. Berman, R. Taillefer, J. Udelson, M. Devine, J. Lazewatsky, G. Bhat, D. Washburn, D. Patel, T. Mazurek, S. Tandon, S. Bansal, S. Inzucchi, L. Staib, J. Davey, D. Chyun, L. Young, F. Wackers, M. T. Harbinson, G. Wells, J. Dougan, S. Borges-Neto, H. Phillips, A. Farzaneh-Far, Z. Starr, L. K. Shaw, M. Fiuzat, C. O'connor, M. Henzlova, W. L. Duvall, A. Levine, U. Baber, L. Croft, S. Sahni, S. Sethi, L. Hermann, A. Nureldin, A. Gomaa, M. A. T. Soliman, H. A. R. Hany, F. De Graaf, A. Pazhenkottil, H. M. J. Siebelink, J. H. Reiber, M. Ayub, T. Naveed, M. Azhar, A. Van Tosh, T. L. Faber, J. R. Votaw, N. Reichek, B. Pulipati, C. Palestro, K. J. Nichols, K. Okuda, Y. Kirihara, T. Ishikawa, J. Taki, M. Yoshita, M. Yamada, A. Salacata, S. Keavey, V. Chavarri, J. Mills, H. Nagaraj, P. Bhambhani, D. E. Kliner, P. Soman, J. Heo, A. E. Iskandrian, M. Jain, B. Lin, A. Walker, C. Nkonde, S. Bond, A. Baskin, J. Declerck, M. E. Soto, G. Mendoza, M. Aguilar, S. P. Williams, G. Colice, J. R. Mcardle, A. Lankford, D. K. Kajdasz, C. R. Reed, L. Angelini, F. Angelozzi, G. Ascoli, A. Jacobson, H. J. Lessig, M. C. Gerson, M. D. Cerqueira, J. Narula, M. Uematsu, K. Kida, K. Suzuki, P. E. Bravo, K. Fukushima, M. Chaudhry, J. Merrill, A. Alonso Tello, J. F. Rodriguez Palomares, G. Marti Aguasca, S. Aguade Bruix, V. Aliaga, P. Mahia, T. Gonzalez-Alujas, J. Candell, A. Evangelista, R. Mlynarski, A. Mlynarska, M. Sosnowski, B. Zerahn, P. Hasbak, C. E. Mortensen, H. F. Mathiesen, M. Andersson, D. Nielsen, L. Ferreira Santos, M. J. Ferreira, D. Ramos, D. Moreira, M. J. Cunha, A. Albuquerque, A. Moreira, J. Oliveira Santos, G. Costa, L. A. Providencia, Y. Arita, S. Kihara, N. Mitsusada, M. Miyawaki, H. Ueda, H. Hiraoka, Y. Matsuzawa, J. Askew, M. O'connor, L. Jordan, R. Ruter, R. Gibbons, T. Miller, L. Emmett, A. Ng, N. Sorensen, R. Mansberg, L. Kritharides, T. Gonzalez, H. Majmundar, N. P. Coats, S. Vernotico, J. H. Doan, T. M. Hernandez, M. Evini, A. D. Hepner, T. K. Ip, W. A. Chalela, A. M. Falcao, L. O. Azouri, J. A. F. Ramires, J. C. Meneghetti, F. Manganelli, M. Spadafora, P. Varrella, G. Peluso, R. Sauro, E. Di Lorenzo, F. Rotondi, S. Daniele, P. Miletto, A. J. M. Rijnders, B. W. Hendrickx, W. Van Der Bruggen, Y. G. C. J. America, P. J. Thorley, F. U. Chowdhury, C. J. Dickinson, S. I. Sazonova, I. Y. U. Proskokova, A. M. Gusakova, S. M. Minin, Y. U. B. Lishmanov, V. V. Saushkin, G. Rodriguez, F. Roffe, H. Ilarraza, D. Bialostozky, A. N. Kitsiou, P. Arsenos, I. Tsiantis, S. Charizopoulos, S. Karas, R. C. Vidal Perez, M. Garrido, V. Pubul, S. Argibay, C. Pena, M. Pombo, A. B. Ciobotaru, A. Sanchez-Salmon, A. Ruibal Morell, J. R. Gonzalez-Juanatey, E. Rodriguez-Gomez, B. Martinez, D. Pontillo, F. Benvissuto, F. Fiore Melacrinis, S. Maccafeo, E. V. Scabbia, R. Schiavo, Y. Golzar, C. Gidea, J. Golzar, D. Pop-Gorceva, M. Zdravkovska, S. Stojanovski, L. J. Georgievska-Ismail, T. Katsikis, A. Theodorakos, A. Kouzoumi, M. Koutelou, Y. Yoshimura, T. Toyama, H. Hoshizaki, S. Ohshima, M. Inoue, T. Suzuki, A. Uitterdijk, M. Dijkshoorn, M. Van Straten, W. J. Van Der Giessen, D. J. Duncker, D. Merkus, G. Platsch, J. Sunderland, C. Tonge, P. Arumugam, T. Dey, H. Wieczorek, R. Bippus, R. L. Romijn, B. E. Backus, T. Aach, M. Lomsky, L. Johansson, J. Marving, S. Svensson, J. L. Pou, F. P. Esteves, P. Raggi, R. Folks, Z. Keidar, J. W. Askew, L. Verdes, L. Campos, V. Gulyaev, A. Pankova, J. Santos, S. Carmona, I. Henriksson, A. Prata, M. Carrageta, A. I. Santos, K. Yoshinaga, M. Naya, C. Katoh, O. Manabe, S. Yamada, H. Iwano, S. Chiba, H. Tsutsui, N. Tamaki, I. Vassiliadis, E. Despotopoulos, O. Kaitozis, E. Hatzistamatiou, R. Thompson, J. Hatch, M. Zink, B. S. Gu, G. D. Bae, C. M. Dae, G. H. Min, E. J. Chun, S. I. Choi, M. Al-Mallah, K. Kassem, O. Khawaja, D. Goodman, D. Lipkin, L. Christiaens, B. Bonnet, J. Mergy, D. Coisne, J. Allal, N. Dias Ferreira, D. Leite, J. Rocha, M. Carvalho, D. Caeiro, N. Bettencourt, P. Braga, V. Gama Ribeiro, U. S. Kristoffersen, A. M. Lebech, H. Gutte, R. S. Ripa, N. Wiinberg, C. L. Petersen, G. Jensen, A. Kjaer, C. Bai, R. Conwell, R. D. Folks, L. Verdes-Moreiras, D. Manatunga, A. F. Jacobson, D. Belzer, Y. Hasid, M. Rehling, R. H. Poulsen, L. Falborg, J. T. Rasmussen, L. N. Waehrens, C. W. Heegaard, J. M. U. Silvola, S. Forsback, J. O. Laine, S. Heinonen, S. Ylaherttuala, A. Broisat, M. Ruiz, N. C. Goodman, J. Dimastromatteo, D. K. Glover, F. Hyafil, F. Blackwell, G. Pavon-Djavid, L. Sarda-Mantel, L. J. Feldman, A. Meddahi-Pelle, V. Tsatkin, Y.- H. Liu, R. De Kemp, P. J. Slomka, R. Klein, G. Germano, R. S. Beanlands, A. Rohani, V. Akbari, J. G. J. Groothuis, M. Fransen, A. M. Beek, S. L. Brinckman, M. R. Meijerink, M. B. M. Hofman, C. Van Kuijk, S. Kogure, E. Yamashita, J. Murakami, R. Kawaguchi, H. Adachi, S. Oshima, S. Minin, S. Popov, Y. U. Saushkina, G. Savenkova, D. Lebedev, E. Alexandridis, D. Rovithis, C. Parisis, I. Sazonova, V. Saushkin, V. Chernov, L. Zaabar, H. Bahri, S. Hadj Ali, A. Sellem, I. Slim, N. El Kadri, H. Slimen, H. Hammami, S. Lucic, A. Peter, S. Tadic, K. Nikoletic, R. Jung, M. Lucic, K. Tagil, D. Jakobsson, S.- E. Svensson, P. Wollmer, L. Leccisotti, L. Indovina, L. Paraggio, M. L. Calcagni, A. Giordano, M. Kapitan, A. Paolino, M. Nunez, J. Sweeny, N. Kulkarni, K. Guma, Y. Akashi, M. Takano, M. Takai, S. Koh, F. Miyake, N. Torun, G. Durmus Altun, A. Altun, E. Kaya, H. Saglam, D. T. Matsuoka, A. Sanchez, C. Bartolozzi, D. Padua, G. Ponta, A. Ponte, A. Carneiro, A. Thom, R. Ashrafi, P. Garg, G. Davis, A. Falcao, M. Costa, F. Bussolini, J. A. C. Meneghetti, M. Tobisaka, E. Correia, J. W. Jansen, P. A. Van Der Vleuten, T. P. Willems, F. Zijlstra, M. Sato, K. Taniguchi, M. Kurabayashi, D. Pop Gjorcheva, M. Zdraveska-Kochovska, K. Moriwaki, A. Kawamura, K. Watanabe, T. Omura, S. Sakabe, T. Seko, A. Kasai, M. Ito, M. Obana, T. Akasaka, C. Hruska, D. Truong, C. Pletta, D. Collins, C. Tortorelli, D. Rhodes, M. El-Prince, A. Martinez-Moeller, M. Marinelli, S. Weismueller, C. Hillerer, B. Jensen, S. G. Nekolla, H. Wakabayashi, K. Tsukamoto, S. M. E. A. Baker, K. M. H. S. Sirajul Haque, A. Siddique, S. Krishna Banarjee, A. Ahsan, F. Rahman, M. Mukhlesur Rahman, T. Parveen, M. Lutfinnessa, F. Nasreen, H. Sano, S. Naito, M. L. De Rimini, G. Borrelli, F. Baldascino, P. Calabro, C. Maiello, A. Russo, C. Amarelli, P. Muto, I. Danad, P. G. Raijmakers, Y. E. Appelman, O. S. Hoekstra, J. T. Marcus, A. Boonstra, D. V. Ryzhkova, T. V. Kuzmina, O. S. Borodina, M. A. Trukshina, I. S. Kostina, H. Hommel, G. Feuchtner, O. Pachinger, G. Friedrich, A. M. Stel, J. W. Deckers, V. Gama, A. Ciarka, L. A. Neefjes, N. R. Mollet, E. J. Sijbrands, J. Wilczek, C. Llibre Pallares, O. Abdul-Jawad Altisent, H. Cuellar Calabria, P. Mahia Casado, M. T. Gonzalez-Alujas, A. Evangelista Masip, D. Garcia-Dorado Garcia, Y. Tekabe, X. Shen, Q. Li, J. Luma, D. Weisenberger, A. M. Schmidt, R. Haubner, L. Johnson, L. Sleiman, S. Thorn, M. Hasu, M. Thabet, J. N. Dasilva, S. C. Whitman, D. Genovesi, A. Giorgetti, A. Gimelli, G. Cannizzaro, F. Bertagna, G. Fagioli, M. Rossi, R. Bonini, P. Marzullo, C. A. Paterson, S. A. Smith, A. D. Small, N. E. R. Goodfield, W. Martin, S. Nekolla, H. Sherif, S. Reder, M. Yu, A. Kusch, D. Li, J. Zou, M. S. Lloyd, K. Cao, D. W. Motherwell, A. Rice, G. M. Mccurrach, S. M. Cobbe, M. C. Petrie, I. Al Younis, E. Van Der Wall, T. Mirza, M. Raza, H. Hashemizadeh, L. Santos, B. A. Krishna, F. Perna, M. Lago, M. Leo, G. Pelargonio, G. Bencardino, M. L. Narducci, M. Casella, F. Bellocci, S. Kirac, O. Yaylali, M. Serteser, T. Yaylali, A. Okizaki, Y. Urano, M. Nakayama, S. Ishitoya, J. Sato, Y. Ishikawa, M. Sakaguchi, N. Nakagami, T. Aburano, S. V. Solav, R. Bhandari, S. Burrell, S. Dorbala, I. Bruno, C. Caldarella, A. Collarino, M. V. Mattoli, A. Stefanelli, A. Cannarile, F. Maggi, V. Soukhov, S. Bondarev, A. Yalfimov, M. Khan, P. P. Priyadharshan, G. Chandok, T. Aziz, M. Avison, R. A. Smith, D. S. Bulugahapitya, T. Vakhtangadze, F. Todua, M. Baramia, G. Antelava, N.- C. Roche, P. Paule, S. Kerebel, J.- M. Gil, L. Fourcade, A. Tzonevska, K. Tzvetkov, M. Atanasova, V. Parvanova, A. Chakarova, E. Piperkova, B. Kocabas, H. Muderrisoglu, C. P. Allaart, E. Entok, S. Simsek, B. Akcay, I. Ak, E. Vardareli, M. Stachura, P. J. Kwasiborski, G. J. Horszczaruk, E. Komar, A. Cwetsch, B. Zraik, R. Morales Demori, A. D. J. Almeida, M. E. Siqueira, E. Vieira, I. Balogh, G. Kerecsen, E. Marosi, Z. S. Szelid, A. Sattar, T. Swadia, J. Chattahi, W. Qureshi, F. Khalid, A. Gonzalez, S. Hechavarria, K. Takamura, S. Fujimoto, R. Nakanishi, S. Yamashina, A. Namiki, J. Yamazaki, K. Koshino, Y. Hashikawa, N. Teramoto, M. Hikake, S. Ishikane, T. Ikeda, H. Iida, Y. Takahashi, N. Oriuchi, H. Higashino, K. Endo, T. Mochizuki, K. Murase, A. Baali, R. Moreno, M. Chau, H. Rousseau, F. Nicoud, P. Dolliner, L. Brammen, G. Steurer, T. Traub-Weidinger, P. Ubl, P. Schaffarich, G. Dobrozemsky, A. Staudenherz, M. Ozgen Kiratli, B. Temelli, N. B. Kanat, T. Aksoy, G. A. Slavich, G. Piccoli, M. Puppato, S. Grillone, D. Gasparini, S. Perruchoud, C. Poitry-Yamate, M. Lepore, R. Gruetter, T. Pedrazzini, D. Anselm, A. Anselm, H. Atkins, J. Renaud, R. Dekemp, I. Burwash, A. Guo, R. Beanlands, C. Glover, I. Vilardi, B. Zangheri, L. Calabrese, P. Romano, A. Bruno, O. C. Fernandez Cimadevilla, V. A. Uusitalo, M. Luotolahti, M. Wendelin-Saarenhovi, J. Sundell, O. Raitakari, S. Huidu, R. Gadiraju, M. Ghesani, Q. Uddin, B. Wosnitzer, N. Takahashi, E. Alhaj, A. Legasto, B. Abiri, K. Elsaban, T. El Khouly, T. El Kammash, A. Al Ghamdi, B. Kyung Deok, K. Bon Seung, Y. Sang Geun, D. Chang Min, and M. Gwan Hong

Subjects
Cardiology and Cardiovascular Medicine
Published
2011
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27. INHERITANCE OF FRUIT CLUSTER CHARACTERISTICS ASSOCIATED WITH SIZE AND UNIFORMITY OF FRUIT

Author

H. Yoshida, T. Mochizuki, Y Noguchi, M. Okimura, K. Sone, and E. Kitadani

Subjects
Horticulture, Inflorescence, Plant morphology, Peduncle (anatomy), Rosaceae, Coefficient of variation, food and beverages, Cultivar, Biology, Heritability, Fragaria, biology.organism_classification
Abstract

This study investigated the inheritance of morphological inflorescence characteristics associated with fruit size in 'Pajaro' and 'Nyoho', their F 1 progeny and their self progeny. Fruit size was highly correlated with the product of fruit arising node/total peduncle length ratio and fruit arising node/lower node diameter ratio (i.e., the fruit arising node length and diameter ratio). This characteristic was quantitatively inherited. The broad sense heritability in F 1 and self progenies derived from the two parental cultivars ranged from 0.795 to 0.895. The coefficient of variation of fruit size was highly correlated with that of state that it correlated with the C.V. of fruit arising node length rations. This characteristic was quantitatively inherited, and the distribution curve was slightly inclined to the ovary parental side, suggesting influence by the ovary parent. The broad sense heritability in F 1 and self progenies derived from the two parental cultivars ranged from 0.601 to 0.826. A breeding line 'Kurume No. 59' which was adapted to forcing culture demonstrated desirable characteristics suitable for saving labor in harvesting and preparation. The fruit is large (24.2 g), uniform (35% C.V. of weight), has good flavour and a long shelf life, and is suitable for using a prototype harvesting robot.

Published
2009
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29. Penile strangulation due to a metal ring: A case report

Author

K, Matsumiya, primary, T, Kawahara, primary, Y, Yamashita, primary, Y, Hayashi, primary, K, Shimokihara, primary, S, Tsutsumi, primary, D, Takamoto, primary, T, Mochizuki, primary, Y, Hattori, primary, J, Teranishi, primary, Y, Miyoshi, primary, Y, Yumura, primary, M, Yao, primary, and H, Uemura, primary

Published
2017
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30. A Case of Diffuse Cavernous Hemangioma of the Rectum Associated with Various Vascular Disorders

Author

Hiroshi Nakada, T Nagamine, Hideyuki Ishida, T Mochizuki, Masaru Yokoyama, Y Fujino, T. Sakimoto, Tsuyoshi Gonda, Keiichiro Ishibashi, and T Kitaoka

Subjects
Hemangioma, medicine.medical_specialty, medicine.anatomical_structure, business.industry, Gastroenterology, medicine, Rectum, Surgery, medicine.disease, business
Abstract

症例は33歳, 男性. 生後2～3カ月時にHirshsprung病の疑いで, S状結腸人工肛門が造設され, その後閉鎖された. 2歳時には直腸血管腫に対し, 外照射治療を受けた (詳細不明). 今回, 繰り返すイレウスと下血の精査・加療を目的に紹介入院となった. 入院後イレウスは保存的に軽快したが, 下血の原因は直腸びまん性血管腫であり, これに対して, 直腸切除・結腸肛門吻合術を施行した. 術前の画像診断では指摘できなかったが, 開腹時に虫垂のほぼ全長にびまん性血管腫を認めたため, 虫垂切除術も同時に行った. 術後15カ月の現在, 下血はなく健在である. 本症例は直腸びまん性血管腫に虫垂びまん性血管腫を合併していたこと, 臀部の皮膚に血管腫, 左下腿に静脈性血管瘤, 内腸骨血管の動静脈瘻を併存しており, Blue rubber bleb syndromeとは異なるものの, 血管系の異常の結果生じた稀な疾患単位の可能性があり, きわめて貴重な症例と考えられる.

Published
2007
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31. Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells

Author

K Hirose, Shuichi Furuta, Kendo Kiyosawa, T Mochizuki, Wei Hao Shang, Tohru Kamata, Y Yokoo, Junji Mitsushita, A Konagai, Maki Yamaura, M Ito, Jun Nakayama, and Satoshi Ishizone

Subjects
Cancer Research, Apoptosis, Adenocarcinoma, MAP Kinase Kinase Kinase 5, Onium Compounds, Cell Line, Tumor, Genetics, Humans, ASK1, Enzyme Inhibitors, Phosphorylation, RNA, Small Interfering, Molecular Biology, Protein kinase B, NADPH oxidase, biology, Kinase, NADPH Oxidases, NOX4, Pancreatic Neoplasms, NADPH Oxidase 4, NAD(P)H oxidase, biology.protein, Cancer research, Reactive Oxygen Species, Proto-Oncogene Proteins c-akt, Signal Transduction
Abstract

Pancreatic adenocarcinoma is an aggressive human malignancy and is characterized by resistance to apoptosis. Recently, NADPH oxidase (Nox) 4-mediated generation of intracellular reactive oxygen species (ROS) was proposed to confer antiapoptotic activity and thus a growth advantage to pancreatic cancer cells. The signaling mechanism by which Nox4 transmits cell survival signals remains unclear. Here, we show that both a flavoprotein inhibitor, diphenylene iodonium (DPI), and small interfering RNAs designed to target Nox4 mRNA (siNox4RNAs) inhibited superoxide production in PANC-1 pancreatic cancer cells, and depletion of ROS by DPI or siNox4RNAs induced apoptosis. Parallely, DPI treatment and siNox4RNA transfection blocked activation of the cell survival kinase AKT by attenuating phosphorylation of AKT. Furthermore, AKT phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) on Ser-83 was reduced by DPI and siNox4RNAs. When ASK1Ser83Ala (an AKT phosphorylation-defective ASK1 mutant) was introduced into PANC-1 cells, this mutant alone induced apoptosis. But, addition of DPI or co-transfection of siNox4RNA had no additive effect, indicating that the mutant can substitute for these reagents in apoptosis induction. Taken together, these findings suggest that ROS generated by Nox4, at least in part, transmit cell survival signals through the AKT-ASK1 pathway in pancreatic cancer cells and their depletion leads to apoptosis.

Published
2006
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33. Secondary systemic amyloidosis associated with frequently infected hepatic cysts in a patient with autosomal dominant polycystic kidney disease

Author

H Kamimura, Hiroshi Nihei, H Kobayashi, Tetsuya Ogawa, T Mochizuki, Ken Tsuchiya, and Kazuho Honda

Subjects
Pathology, medicine.medical_specialty, business.industry, Amyloidosis, Autosomal dominant polycystic kidney disease, Autopsy, General Medicine, medicine.disease, Nephrology, medicine, Cyst, Secondary systemic amyloidosis, Hepatic Cyst, Complication, business, Kidney disease
Published
2003
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34. Malignant Retroperitoneal Paraganglial Tumour in a Cow

Author

Yoshiyasu Kobayashi, Hidefumi Furuoka, Takane Matsui, Kazuya Matsuda, Takashi Umemura, and T. Mochizuki

Subjects
Silver Staining, Pathology, medicine.medical_specialty, Lung Neoplasms, Enolase, Cattle Diseases, Biology, Cytoplasmic Granules, Cell junction, Pathology and Forensic Medicine, Immunoenzyme Techniques, Paraganglioma, Cytokeratin, Biomarkers, Tumor, medicine, Animals, Neoplasm, Endocrine system, Retroperitoneal Neoplasms, Ganglia, Sympathetic, General Veterinary, Desmosomes, medicine.disease, Kidney Neoplasms, Ganglion, medicine.anatomical_structure, Phosphopyruvate Hydratase, Keratins, Cattle, Female, Lymph Nodes, Lymph, Organ of Zuckerkandl
Abstract

A large primary retroperitoneal sublumbar neoplasm was identified in an 11-year-old Holstein cow, with metastases to the lungs, kidneys and lymph nodes. The tumour cells proliferated in a characteristic endocrine pattern, were argyrophilic and positive for neuron-specific enolase, and had membrane-bounded intracytoplasmic granules. In addition, the cells were occasionally positive for cytokeratin and had desmosome-like intercellular junctions. The primary tumour mass was diagnosed as a malignant paraganglial tumour of the aortico-sympathetic ganglion (organ of Zuckerkandl), and was considered to contain primitive cells with epithelial differentiation.

Published
2003
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35. Single-copy RAPD marker loci undetectable in octoploid strawberry

Author

S. Matsumoto, T. Mochizuki, N. Fukino, and Z. Zhang

Subjects
Genetics, education.field_of_study, Population, Dna concentration, Horticulture, Single copy, Biology, law.invention, RAPD, law, Polymorphism (computer science), Cultivar, education, Polymerase chain reaction
Abstract

SummaryRandom amplified polymorphic DNA (RAPD) was used to examine two selfed populations and two cross populations of octoploid strawberry obtained from two parents, cultivars Sachinoka and Cesena. The polymorphic bands of one parent appeared not only on the individuals of its selfed population, but also on the individuals of another parent’s selfed population. In the selfed population of ‘Cesena’, the percentage of individuals presenting the polymorphic band of ‘Sachinoka’ was 10.3% to 41.4%, while in selfed population of ‘Sachinoka’, the percentage of individuals presenting the polymorphic band of Cesena was 13.8%. The result of experiments on an artificial mixture of DNA from two parents showed that polymorphism was never detected if DNA from ‘Sachinoka’ constituted a proportion of 0.3 or less. There was no change in the effect on polymorphic bands within the range of template DNA concentration in PCR reaction solution from 1 ng μl–1 to 10 ng μl–1. We concluded that single-copy RAPD marker loci are un...

Published
2003
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37. [Untitled]

Author

Hitoshi Asakura, Jun-ichi Ueki, Hirotaka Motoyama, T. Mochizuki, Akira Yoshimura, David H. Van Thiel, Terasu Honma, Takafumi Ichida, Kazuhito Sugimura, Mitsuya Iwafuchi, Yuichi Sato, and Rintaro Narisawa

Subjects
medicine.medical_specialty, Pathology, biology, Physiology, Autoimmune Gastritis, Atrophic gastritis, business.industry, Spirillaceae, Stomach, Gastroenterology, Helicobacter pylori, biology.organism_classification, medicine.disease, medicine.anatomical_structure, Internal medicine, medicine, Gastritis, medicine.symptom, Enterochromaffin-like cell, business, Gastrin
Abstract

In Japan, most cases of gastric carcinoid tumor (GCT) are unassociated with either autoimmune gastritis (AIG) showing type-A chronic atrophic gastritis (CAG-A) or Zollinger-Ellison syndrome (ZES). However, the pathogenesis of this tumor remains unknown. Recent studies have determined that Helicobacter pylori infection induces gastric carcinoid in Mongolian gerbils and that H. pylori lipopolysaccharide exerts a mitogenic effect on ECL cells. We examined five patients with histologically diagnosed GCT, 40 patients with H. pylori-positive gastric ulcer (Hp+GU), 24 patients with H. pylori-positive duodenal ulcer (Hp+DU), and 12 patients with AIG showing CAG-A topographically. We compared the prevalence of H. pylori infection, and the levels of gastrin and pepsinogen (PG) in the serum of patients with GCT with those of patients with Hp+GU, or Hp+DU, and AIG. We also investigated the histological characteristics of the tumor and the gastric corpus mucosa in the GCT patients. The levels of serum gastrin and PG I and II were measured using an RIA kit. In all five (100%) patients with GCT, H. pylori infection was present, without any evidence of AIG or ZES. The serum levels of gastrin in the GCT patients were higher than those in either Hp+GU or Hp+DU patients and lower than those in the AIG patients. In contrast, serum PG I levels and the PG I/II ratio were lower in the GCT group than in the Hp+GU or Hp+DU groups. Histologically, all GCTs were ECL cell tumors and peritumoral corporal mucosal atrophy was observed in four of the five patients with GCT. In conclusions, H. pylori infection and hypergastrinemia were found in the patients with GCT without AIG. This finding suggests that H. pylori infection may induce corporal mucosal atrophy and hypergastrinemia that can produce a GCT with time.

Published
2002
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38. Development of new and non-invasive diagnostic markers on urothelial cells in voided urine for the lower urinary tract symptoms/lower urinary tract dysfunction

Author

Norifumi Sawada, Takahiko Mitsui, T. Mochizuki, H. Shimura, S. Kira, Masayuki Takeda, T. Ihara, H. Nakagomi, Y. Imai, and T. Miyamoto

Subjects
medicine.medical_specialty, Lower urinary tract symptoms, business.industry, Urology, Urinary system, Non invasive, medicine, Diagnostic marker, Urine, medicine.disease, business
Published
2017
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39. Dressed-photon–phonon (DPP)-assisted visible- and infrared-light water splitting

Author

Kokoro Kitamura, T. Mochizuki, Takashi Yatsui, Tsubasa Imoto, and Tadashi Kawazoe

Subjects
Photocurrent, Multidisciplinary, Materials science, Infrared, business.industry, Phonon, Band gap, Cathodoluminescence, Photon energy, Article, Optoelectronics, Nanorod, business, Visible spectrum
Abstract

A dressed-phonon–phonon (DPP) assisted photocatalyst reaction was carried out to increase the visible light responsibility, where the photon energy of the radiation, which ranged from visible to infrared light is less than band gap energy of the photocatalyst (ZnO, 3.3 eV). The dependence of the photocurrent on excitation power indicated that two-step excitation occurred in DPP-assisted process. A cathodoluminescence measurement also supported the conclusion that the visible- and infrared-light excitation originated from DPP excitation, not from defect states in the ZnO nanorod photocatalyst.

Published
2014
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40. Stratification analysis ofMICAtriplet repeat polymorphisms and HLA antigens associated with ulcerative colitis in Japanese

Author

Hitoshi Asakura, Kenji Suzuki, Yoshihiko Katsuyama, Osamu Yoneyama, Masao Ota, T. Mochizuki, S.S. Seki, Jun Matsuzawa, Kazuhito Sugimura, Nobuhisa Mizuki, Kisei Ishizuka, Hidetoshi Inoko, and Terasu Honma

Subjects
Linkage disequilibrium, Immunology, Haplotype, General Medicine, Human leukocyte antigen, Odds ratio, Biology, Major histocompatibility complex, Biochemistry, stomatognathic diseases, Polymorphism (computer science), Genetics, biology.protein, Immunology and Allergy, Population study, Allele
Abstract

We previously reported a conserved haplotype of HLA B52-DR2 and a significantly high frequency of the major histocompatibility complex (MHC) class I chain-related gene A (MICA) transmembrane-short tandem repeat (TM-STR) 6 allele in Japanese patients with ulcerative colitis (UC). To examine the predominance of the MICA TM-STR 6 allele as a marker of the susceptibility to UC within the susceptible haplotype, the association of each allele with UC was estimated following stratification of the patients to control for any possible confounding effects of other alleles positively associated with UC. Sixty-four patients with UC and 236 unrelated healthy controls were included in this study. All subjects were Japanese. HLA-A, -B, -C, and -DR antigens were determined serologically. A triplet repeat polymorphism of the MICA was determined by direct sequencing. To control for the effect of linkage disequilibrium, Mantel-Haenszel weighed odds ratios were calculated. Significantly higher phenotype frequencies of B52, MICA TM-STR 6, and DR2 were observed in patients with UC. Linkage disequilibria among alleles associated with UC revealed that a B52 –MICA TM-STR 6 – DR2 haplotype was conserved in patients with UC, as in controls. When the association of HLA-B52 was estimated after patient stratification for the possible confounding effect of MICA TM-STR 6 or DR2, a strong significant association of B52 with UC was still observed. In contrast, no association with UC was observed for MICA TM-STR 6 or DR2, after stratification of the possible confounding effect of HLA-B52. These results imply that the significant increase in MICA TM-STR 6 in Japanese patients with UC is attributable to linkage disequilibrium with HLA-B52.

Published
2001
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41. SPring-8 standard X-ray monochromator

Author

T. Mochizuki, Yasuhiro Yoneda, Shunji Goto, Hiroshi Yamazaki, Makina Yabashi, T. Ishikawa, and Kenji Tamasaku

Subjects
Physics, Nuclear and High Energy Physics, business.industry, Geometry, SPring-8, Undulator, Radiation, law.invention, Crystal, Optics, Position (vector), law, X ray monochromator, business, Instrumentation, Power density, Monochromator
Abstract

A systematic alignment method is described for fixed-exit position operation of SPring-8 standard monochromator in rotated-inclined geometry. Results of high-heat-load test showed the water-cooled pin-post crystal combined with the geometry well surpass 400 W/mm 2 power density of the X-ray undulator radiation.

Published
2001
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42. Early commissioning of the SPring-8 beamline for high resolution inelastic X-ray scattering

Author

Hidekazu Kimura, Alfred Q. R. Baron, Shunji Goto, F. Yamamoto, T. Ishikawa, Kunikazu Takeshita, Daigo Miwa, Tomohiro Matsushita, T. Mochizuki, Yoshihito Tanaka, and D. Ishikawa

Subjects
Physics, Nuclear and High Energy Physics, Spectrum analyzer, Physics::Instrumentation and Detectors, business.industry, Scattering, Instrumentation, X-ray, Synchrotron radiation, SPring-8, First light, Optics, Beamline, Physics::Accelerator Physics, business
Abstract

BL35XU of SPring-8 is dedicated to the investigation of sample dynamics on ∼meV energy scales using inelastic X-ray scattering and nuclear resonant scattering of synchrotron radiation. The beamline saw first light in February 2000. We briefly describe the beamline design and status. We include results from the early commissioning period, and from our program of instrumentation development, including backscattering monochromators and analyzer crystals.

Published
2001
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43. High average and high peak brightness slab laser

Author

T. Mochizuki and S. Amano

Subjects
High peak, Physics, Brightness, business.industry, Amplifier, chemistry.chemical_element, Pulse duration, Condensed Matter Physics, Laser, Neodymium, Atomic and Molecular Physics, and Optics, law.invention, Optical pumping, Optics, chemistry, law, Slab laser, Electrical and Electronic Engineering, business
Abstract

A high average and high peak brightness Nd:YAG MOPA laser system composed of a laser-diode-pumped Nd:YAG master oscillator, flash-lamp-pumped slab power amplifiers and a phase conjugated mirror was developed. The system demonstrates an average output power of 235 W at a repetition rate of 320 Hz and a peak power of 30 MW at a pulse duration of 24 ns with M/sup 2/=1.5. Both an average brightness of 7/spl times/10/sup 9/ W/cm/sup 2//spl middot/sr and a peak brightness of 1/spl times/10/sup 15/ W/cm2/spl middot/sr are achieved simultaneously. The system design rules that we confirmed suggest that by replacing lamp pumping in the amplifier with laser-diode pumping, an average output power of /spl sim/1 kW can be obtained at /spl sim/1 kHz with a higher average brightness of /spl sim/3/spl times/10/sup 10/ W/cm/sup 2//spl middot/sr and a higher peak brightness of /spl sim/3/spl times/10/sup 15/ W/cm/sup 2//spl middot/sr.

Published
2001
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44. Influence of Interleukin-10 on the Interleukin-1 Receptor Antagonist/Interleukin-1β Ratio in the Colonic Mucosa of Ulcerative Colitis

Author

Kazuaki Otsuka, Kisei Ishizuka, Hitoshi Asakura, Osamu Yamaguchi, Masaaki Kobayashi, Kazunori Tashiro, Jun Matsuzawa, T. Mochizuki, Kouji Suzuki, Terasu Homma, and Kazuhito Sugimura

Subjects
Adult, Male, medicine.medical_treatment, Enzyme-Linked Immunosorbent Assay, Biology, Pathogenesis, medicine, Humans, Intestinal Mucosa, Receptor, Inflammation, Polymorphism, Genetic, Gastroenterology, Antagonist, Receptors, Interleukin-1, Interleukin, Middle Aged, medicine.disease, Ulcerative colitis, digestive system diseases, Interleukin-10, Interleukin 10, Interleukin 1 receptor antagonist, Cytokine, Immunology, Cytokines, Colitis, Ulcerative, Female, Interleukin-1
Abstract

A decrease in the ratio of IL-1ra/IL-1 beta produced regionally by the colonic mucosa of patients with ulcerative colitis (UC) is believed to play a role in the pathogenesis of UC. To investigate factors influencing intramucosal IL-1ra/IL-1 beta ratios, we evaluated polymorphism of the IL-1ra gene and the production of mucosal cytokines in Japanese patients with UC. Colonic biopsy specimens of mucosal tissue were placed in organ cultures for 24 h. Then, the supernatant concentrations of IL-1 beta, IL-1ra, IL-8, IL-4, IL-10, and TGF-beta were assayed by ELISA. Genomic DNA was extracted from patient peripheral blood samples, then IL-1ra gene polymorphism was determined using PCR amplification. The mucosa from patients with active stage UC showed a tendency toward a decreased IL-1ra/IL-1 beta ratio. In the resolving stage, IL-1ra/IL-1 beta ratios increased with increasing IL-10 and TGF-beta concentrations. The addition of human recombinant IL-10 to the culture supernatants produced concentration-dependent inhibition of IL-1 beta. In Japanese patients with UC, the IL-1ra allele gene 2 phenotype had no effect on the IL-1ra/IL-1 beta ratio. Our findings suggest that a relative deficiency of IL-10 in patients with UC may contribute to persistent inflammatory changes.

Published
2001
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45. A close relationship of triplet repeat polymorphism in MHC class I chain-related gene A (MICA) to the disease susceptibility and behavior in ulcerative colitis

Author

T. Mochizuki, Jun Matsuzawa, Kisei Ishizuka, Hidetoshi Inoko, Yoshihiko Katsuyama, Hitoshi Asakura, Kazuhito Sugimura, Masao Ota, Terasu Honma, Nobuhisa Mizuki, and S.S. Seki

Subjects
Genetics, biology, Immunology, Locus (genetics), General Medicine, Human leukocyte antigen, Major histocompatibility complex, Biochemistry, Gastrointestinal epithelium, stomatognathic diseases, MHC class I, biology.protein, Immunology and Allergy, Allele, Gene, Allele frequency
Abstract

Major histocompatibility complex (MHC) class I chain-related gene A (MICA) has been found near the HLA-B gene. The MICA molecule is exclusively expressed on gastrointestinal epithelium and recognized by intestinal epithelial gamma delta T cells, where it exhibits a triplet repeat polymorphism in the transmembrane region. We investigated the possible correlation between MICA genetic polymorphism and ulcerative colitis (UC). Eighty-three patients with UC and 132 unrelated controls were included in this study. All subjects were Japanese. A triplet repeat polymorphism in the transmembrane region of the MICA was determined by direct sequencing procedures after amplification by a polymerase chain reaction. A significantly higher allele and phenotype frequencies of MICA A6 allele were observed in patients with UC than controls (allele frequency: P(c)=0.000011, phenotype frequency: P(c)=0.0049 odds ratio=2.62). A6 homozygous patients with UC showed significantly earlier onset of UC than patients without the A6 allele ((P)c=0.0042). Phenotypes of MICA A6 allele in Japanese are closely related to the disease susceptibility and behavior in UC. Examinations of MICA polymorphism in other ethnic groups may provide important information about the locus of primary responsible gene for UC.

Published
2001
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46. Rapid analysis of steelmaking slag by energy-dispersive X-ray fluorescence spectrometry

Author

T. Mochizuki, M. Okano, S. Sato, Y. Yoshioka, and H. Nagashima

Subjects
Materials science, business.industry, Metallurgy, Metals and Alloys, Slag, Condensed Matter Physics, Steelmaking, Scientific method, Present method, visual_art, Materials Chemistry, visual_art.visual_art_medium, Energy Dispersive X-Ray Fluorescence Spectrometry, Physical and Theoretical Chemistry, business
Abstract

Rapid analysis of steelmaking slag by the combination of a new sampling technique and EDX has been developed.In the present method, the analysis time has been shortened to about 5 min. Moreover, the features of the present method are low cost, easy operation and useful accuracy for the process control.By using the present method, it has been possible to control the process by feedback of the slag composition in nearly real time in the steelmaking process.

Published
2000
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47. Fas/Fas Ligand Expression and Characteristics of Primed CD45RO+T Cells in the Inflamed Mucosa of Ulcerative Colitis

Author

T. Mochizuki, A. Suzuki, Rintarou Narisawa, Katsuhiko Hasegawa, Kenji Suzuki, K. Ohtsuka, Asakura H, Kazuhito Sugimura, T. Honma, and Kisei Ishizuka

Subjects
Adult, Male, Fas Ligand Protein, CD8 Antigens, T-Lymphocytes, Apoptosis, chemical and pharmacologic phenomena, Inflammation, Ligands, Fas ligand, Immune system, In Situ Nick-End Labeling, medicine, Humans, Cytotoxic T cell, fas Receptor, Intestinal Mucosa, Membrane Glycoproteins, TUNEL assay, business.industry, Gastroenterology, hemic and immune systems, T lymphocyte, Middle Aged, Flow Cytometry, Molecular biology, digestive system diseases, CD4 Antigens, Immunology, Leukocyte Common Antigens, Colitis, Ulcerative, Female, medicine.symptom, business, CD8
Abstract

Chronic immune activation in the colon is characteristic of ulcerative colitis (UC). Fas/Fas ligand (FasL) system is a mechanism responsible for activation-induced cell death (AICD), which maintains homeostasis within the immune system. Thus, Fas/FasL expression on activated colonic T cells of UC patients, as well as the susceptibility of such T cells to AICD was investigated in order to determine the role of activated colonic T cells in the long lasting inflammation in UC.Fas, FasL, and CD45RO expression on peripheral blood and colonic T cells of UC patients were assayed by flow cytometry. Apoptosis of colonic T cells induced by anti Fas antibody was assessed using the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) assay.The majority of colonic T cells expressed both CD45RO and Fas in the colonic mucosa, a situation that was quite different from that in the peripheral blood. The number of CD45RO+CD8+ and Fas+CD8+ T cells was significantly lower in UC patients than the controls, unlike the number of Fas+CD4+ T cells. In contrast, the number of both CD45RO+CD4+ and CD45RO+CD8+ T cells in UC mucosa expressing FasL was significantly higher than in the controls. While Fas mediated apoptosis of CD45RO+CD8+ T cells was higher in UC patients than the controls, the number of apoptotic CD45RO+CD4+ T cells from UC mucosa was not.In UC patients, CD45RO+CD4+ T cells are less sensitive to apoptotic signals mediated by Fas. These phenomena may contribute to the pathogenesis of UC.

Published
2000
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48. C. レーザーエネルギー応用

Author

S. Yamagami, H. Daido, H. Nagatomo, M. Suzuki, Y. Murakami, Li Woo Choi, H. Fiedorowicz, A. Bartnik, R. Rakowski, W. Yu, A. Sasaki, T. Utsumi, K. Moribayashi, T. Kawachi, M. Kado, N. Hasegawa, Y. Ueshima, T. Tajima, Yuzo Nagumo, Shigeki Hayashi, Takashi Yagi, Takeshi Matsumura, Susumu Yamazaki, Isao Kojima, Kazumasa Honda, A. Shimoura, T. Mochizuki, S. Miyamoto, S. Amano, Denis Joyeux, Daniel Phalippou, Gerard Jamelot, E. Takahashi, I. Okuda, Y. Matsumoto, I. Matsushima, S. Kato, K. Kuwahara, Y. Owadano, M. Iwasaki, T. Jitsuno, S. Motokoshi, N. Nishi, M. Nakatsuka, Koichi Mori, Kimiya Komurasaki, Yoshihiro Arakaw, M. Ishimoto, S. Uchida, K. Imasaki, X. Zhou, S. Sakabe, N. Kawashima, Shinichirou OKIHARA, Fuminobu SATOA, Takehiro SHIMADA, Kouji TAKAHASHI, Yusuke SAKABE, Takayoshi NORIMA'TUA, Yasukazu IZAWAA, Toshiyuki IIDA, Kazuhisa NAKAJIMA, Shuhei KANAZAWA, Masaki KANDO, Shuji KONDO, Hideyuki KOTAKI, Hideki DEWA, Tomonao HOSOKAI, M. YODA, Y. BABA, N. MUKAI, Y. SANO, T. OGlSU, M. Yamaura, S. Ihara, S. Satoh, C. Yamabe, S. Nozawa, Y. Shimada, A. Ogata, T. Yamanaka, C. Yamanaka, Y. Ishikubo, and K. Kawabata

Published
2000
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49. A CASE OF LYMPHANGIOMA OF THE LESSER OMENTUM

Author

Akira Oya, Hidenori Ueki, Tatsuo Tani, Koei Nihei, T. Mochizuki, and Takeyasu Suda

Subjects
Lesser omentum, medicine.anatomical_structure, business.industry, Lymphangioma, medicine, Anatomy, business, medicine.disease
Published
1999
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50. [Untitled]

Author

David H. Van Thiel, Kazuhito Sugimura, Yuichi Sato, Hitoshi Asakura, Rintaro Narisawa, H. Suriki, Terasu Honma, Takafumi Ichida, Kisei Ishizuka, T. Mochizuki, and Kazunori Tashiro

Subjects
Chemokine, medicine.medical_specialty, biology, Physiology, business.industry, Stomach, Spirillaceae, Gastroenterology, Helicobacter pylori, biology.organism_classification, medicine.anatomical_structure, Internal medicine, Duodenum, medicine, Gastric mucosa, biology.protein, Gastritis, medicine.symptom, business, Antrum
Abstract

It is well known that antrum-predominantgastritis and pan-gastritis occurs in the patients withHelicobacter pylori-positive duodenal ulcer (DU) andgastric ulcer (GU), respectively. However, the role of chemokines in the pathogenesis of thesepathologies is unclear. We examined the regionaldifferences in mucosal chemokine production in patientswith DU and GU. The production of interleukin-8 (IL-8), growth-related gene (GRO) α, andmacrophage inflammatory protein (MIP)-1α wasgreater in the antrum than in the corpus in DU patients.In the patients with GU, monocyte chemoattractantprotein (MCP)-1 levels in the mucosa adjacent to ulcer weregreater than those away for the ulcer in the corpus. Thereduction in chemokine production occurring inassociation with the eradication of H. pylori differed between DU and GU patients in the antrum (IL-8,P = 0.0394; GROα, P = 0.0149; MIP-1α, P =0.0246; MCP-1, P = 0.0087). The data imply a differentpathogenesis may exist for the gastritis present in patients with DU and GU occurring in H.pylori-positive individuals.

Published
1999
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