14,792 results on '"T Inoue"'
Search Results
2. Perinatal bile acid metabolism: analysis of urinary bile acids in pregnant women and newborns
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A Kimura, M Suzuki, T Murai, T Inoue, H Kato, D Hori, Y Nomura, T Yoshimura, T Kurosawa, and M Tohma
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Biochemistry ,QD415-436 - Abstract
The metabolism of bile acids in 30 pregnant women was evaluated by analyzing the urinary composition of bile acids during late gestation (weeks 30-41) and again in these women and their newborn infants during the first week after delivery. The levels of individual bile acids were determined by gas chromatography-mass spectrometry after solvolysis and hydrolysis of bile acid conjugates. The mean total bile acid/creatinine ratio in pregnant women decreased from 1.22 micromol/mmol creatinine at 30-32 weeks of gestation to 0.15 micromol/mmol creatinine at 6-7 days after delivery. The mean percentage of 1beta-hydroxylated bile acids peaked at 27﹪ at 3-4 days after delivery. In newborn infants, the mean total bile acid/creatinine ratio rapidly increased from 3.39 micromol/mmol creatinine at birth to 54.33 micromol/mmol creatinine at 7 days. During this period, large amounts (40-50﹪) of unsaturated ketonic bile acids, especially 7alpha,12alpha-dihydroxy-3-oxo-5beta-chol-1-en-24-oic acid and 7alpha,12alpha-dihydroxy-3-oxo-4-cholen-24-oic acid, were observed in the infants' urine. These data suggest that, during the perinatal period, the formation of polyhydroxylated and unsaturated ketonic bile acids probably represents a mechanism for the excretion of bile salts, and that the metabolism of bile acids in both the mother and the infant changes significantly after birth.
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- 1997
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3. Inhibition of cholesterol absorption and synthesis in rats by sesamin
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N Hirose, T Inoue, K Nishihara, M Sugano, K Akimoto, S Shimizu, and H Yamada
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Biochemistry ,QD415-436 - Abstract
The effects of sesamin, a lignan from sesame oil, on various aspects of cholesterol metabolism were examined in rats maintained on various dietary regimens. When given at a dietary level of 0.5% for 4 weeks, sesamin reduced the concentration of serum and liver cholesterol significantly irrespective of the presence or absence of cholesterol in the diet, except for one experiment in which the purified diet free of cholesterol was given. On feeding sesamin, there was a decrease in lymphatic absorption of cholesterol accompanying an increase in fecal excretion of neutral, but not acidic, steroids, particularly when the cholesterol-enriched diet was given. Sesamin inhibited micellar solubility of cholesterol, but not bile acids, whereas it neither bound taurocholate nor affected the absorption of fatty acids. Only a marginal proportion (ca. 0.15%) of sesamin administered intragastrically was recovered in the lymph. There was a significant reduction in the activity of liver microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase after feeding sesamin, although the activity of hepatic cholesterol 7 alpha-hydroxylase, drug metabolizing enzymes, and alcohol dehydrogenase remained uninfluenced. Although the weight and phospholipid concentration of the liver increased unequivocally on feeding sesamin, the histological examination by microscopy showed no abnormality, and the activity of serum GOT and GPT remained unchanged. Since sesamin lowered both serum and liver cholesterol levels by inhibiting absorption and synthesis of cholesterol simultaneously, it deserves further study as a possible hypocholesterolemic agent of natural origin.
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- 1991
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4. ALMA Observations of Supernova Remnant N49 in the Large Magellanic Cloud. II. Non-LTE Analysis of Shock-heated Molecular Clouds
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H. Sano, Y. Yamane, J. Th. van Loon, K. Furuya, Y. Fukui, R. Z. E. Alsaberi, A. Bamba, R. Enokiya, M. D. Filipović, R. Indebetouw, T. Inoue, A. Kawamura, M. Lakićević, C. J. Law, N. Mizuno, T. Murase, T. Onishi, S. Park, P. P. Plucinsky, J. Rho, A. M. S. Richards, G. Rowell, M. Sasaki, J. Seok, P. Sharda, L. Staveley-Smith, H. Suzuki, T. Temim, K. Tokuda, K. Tsuge, and K. Tachihara
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Supernova remnants ,Interstellar medium ,Molecular clouds ,X-ray sources ,Astrophysics ,QB460-466 - Abstract
We present the first compelling evidence of shock-heated molecular clouds associated with the supernova remnant (SNR) N49 in the Large Magellanic Cloud (LMC). Using ^12 CO( J = 2–1, 3–2) and ^13 CO( J = 2–1) line emission data taken with the Atacama Large Millimeter/Submillimeter Array, we derived the H _2 number density and kinetic temperature of eight ^13 CO-detected clouds using the large velocity gradient approximation at a resolution of 3.″5 (∼0.8 pc at the LMC distance). The physical properties of the clouds are divided into two categories: three of them near the shock front show the highest temperatures of ∼50 K with densities of ∼500–700 cm ^−3 , while other clouds slightly distant from the SNR have moderate temperatures of ∼20 K with densities of ∼800–1300 cm ^−3 . The former clouds were heated by supernova shocks, but the latter were dominantly affected by the cosmic-ray heating. These findings are consistent with the efficient production of X-ray recombining plasma in N49 due to thermal conduction between the cold clouds and hot plasma. We also find that the gas pressure is roughly constant except for the three shock-engulfed clouds inside or on the SNR shell, suggesting that almost no clouds have evaporated within the short SNR age of ∼4800 yr. This result is compatible with the shock-interaction model with dense and clumpy clouds inside a low-density wind bubble.
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- 2023
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5. Alluvial cover on bedrock channels: applicability of existing models
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J. Mishra and T. Inoue
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Dynamic and structural geology ,QE500-639.5 - Abstract
Several studies have demonstrated the importance of alluvial cover; furthermore, several mathematical models have also been introduced to predict the alluvial cover on bedrock channels. Here, we provide an extensive review of research exploring the relationship between alluvial cover, sediment supply and bed topography of bedrock channels, describing various mathematical models used to analyse the deposition of alluvium. To test one-dimensional theoretical models, we performed a series of laboratory-scale experiments with varying bed roughness under simple conditions without bar formation. Our experiments show that alluvial cover is not merely governed by increasing sediment supply and that bed roughness is an important controlling factor of alluvial cover. A comparison between the experimental results and the five theoretical models shows that (1) two simple models that calculate alluvial cover as a linear or exponential function of the ratio of the sediment supplied to the capacity of the channel produce good results for rough bedrock beds but not for smoother bedrock beds; (2) two roughness models which include changes in roughness with alluviation and a model including the probability of sediment accumulation can accurately predict alluvial cover in both rough and smooth beds; and (3), however, except for a model using the observed hydraulic roughness, it is necessary to adjust model parameters even in a straight channel without bars.
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- 2020
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6. Subsidence of rice paddy and upland crop fields in Shinotsu Peatland, Hokkaido, Japan
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M. Yokochi, K. Sekimoto, and T. Inoue
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Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
Agricultural land use on peatlands inevitably causes ongoing land surface subsidence resulting in a reduction of productivity. In addition, oxidation of the peat substrate associated with subsidence is responsible for greenhouse gas emission with the ensuing consequence for global climatic stability. A concept of “paludiculture”, the utilisation of wet or rewetted peatlands for agriculture, has been proposed in European countries to avoid further subsidence and greenhouse gas emission. However, few studies have documented a long-term record of subsidence through agriculture in wet peatlands such as paddy fields for rice cultivation. In this study, we measured the subsidence rates of peatland in rice paddy use and compared them to the rates in peatland with upland crop cultivation. The average subsidence between 2006 and 2016 for the paddy plots was 3.6±1.9 cm (± SE) and significantly less than that of 25.6±1.7 cm for the upland plots, and the subsidence reduced linearly as the period of paddy use increased. These results suggest that paddy use of peatlands can effectively reduce subsidence. Our results will encourage the use of peatlands with a wet environment as one of the valid options for future peatland management in terms of mitigation of land subsidence and peat loss.
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- 2020
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7. Synthesis and Characterization of Zinc, Iron, Copper, and Manganese Oxides Nanoparticles for Possible Application as Plant Fertilizers
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Michel E. Neto, David W. Britt, Kyle A. Jackson, João H. V. Almeida Junior, Rodrigo S. Lima, Dimas A. M. Zaia, Tadeu T. Inoue, and Marcelo A. Batista
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Article Subject ,General Materials Science - Abstract
This research evaluates the synthesis and characterization of nanometric-sized metallic particles with potential application as support materials for supplying nutrients to plants. Nanoscale Zn, Mn, Fe, and Cu oxides particles were synthesized using microwave-assisted synthesis. Nanoparticles (NPs) were characterized with Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), specific surface area (SSA), and total chemical analysis. Synthesized NPs were all in oxide forms and characterized for confirmation of size, shape, surface structure, crystalline nature, and study of elemental proportion. The results indicate that synthesized NPs size was ranged between 20 and 50 nm and was all in their respective oxide forms as ZnO, Mn3O4, Fe3O4, and CuO.
- Published
- 2023
8. Factors and outcomes associated with improved left ventricular systolic function in patients with cardiomyopathy
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Dylan Eiger, Daniel P. Fishbein, Zainab Samad, Jeanne E. Poole, Kerry L. Lee, Daniel Friedman, Sana M. Al-Khatib, Gillian D Sanders, Daniel B. Mark, Qijun Li, Lurdes Y. T. Inoue, and Gust H. Bardy
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medicine.medical_specialty ,medicine.medical_treatment ,Cardiomyopathy ,Placebo ,Ventricular Function, Left ,Sudden cardiac death ,QRS complex ,Risk Factors ,Internal medicine ,Humans ,Medicine ,In patient ,cardiovascular diseases ,Heart Failure ,Ejection fraction ,business.industry ,Stroke Volume ,General Medicine ,medicine.disease ,Implantable cardioverter-defibrillator ,humanities ,Defibrillators, Implantable ,Death, Sudden, Cardiac ,Heart failure ,cardiovascular system ,Cardiology ,Female ,Cardiomyopathies ,Cardiology and Cardiovascular Medicine ,business ,therapeutics ,circulatory and respiratory physiology - Abstract
Background: Many patients in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) had a significant improvement (> 10%) in the left ventricular ejection fraction (LVEF) during the course of the study, but the factors and outcomes associated with such improvement are uncertain. Methods: We examined factors and rates of mortality, cause-specific mortality, and implantable cardioverter defibrillator (ICD) shocks associated with improvement in LVEF by analyzing patients in the SCD-HeFT who were randomized to placebo or an ICD and who had an LVEF checked during follow-up. Results: During a median follow-up of 3.99 years, of 837 patients who had at least two follow-up LVEF measurements, 276 (33%) patients had > 10% improvement in LVEF and 561 (67%) patients had no significant change in LVEF. Factors significantly associated with LVEF improvement included female sex, white race, history of hypertension, a QRS duration < 120 ms, and beta-blocker use. Improvement in LVEF was associated with a significant improvement in survival. There was no significant association between improvement in LVEF and cause-specific death, but there was a significant association between improvement in LVEF and reduced risk of receiving appropriate ICD shocks. Conclusions: About a third of patients in this analysis, who were randomized to placebo or an ICD in SCD-HeFT, had a significant improvement in LVEF during follow-up; improvement in LVEF was associated with improved survival but not with cause-specific death, and with decreased likelihood of receiving appropriate ICD shocks.
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- 2022
9. Development of foods with function claims based on the health benefits of tomato-derived nutrients
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K. Yoshida, T. Inoue, K. Aizawa, and H. Suganuma
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Horticulture - Published
- 2022
10. The prognostic value of 18F-FDG PET/CT taken immediately after completion of radiotherapy for lung cancer treated with concurrent chemoradiotherapy: A pilot study
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A. Harigai, A.I. Saito, T. Inoue, M. Suzuki, Y. Namba, Y. Suzuki, F. Makino, O. Nagashima, S. Sasaki, and K. Sasai
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Oncology ,Radiology, Nuclear Medicine and imaging - Published
- 2022
11. DISSEMINATION OF THE 'TOUCH THE UNIVERSE' TACTILE EXHIBITION
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K. Usuda-Sato, Y. Suzuki, S. Kawashima, Y. Goko, and T. Inoue
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General Medicine - Abstract
We created a whole set of the "Touch the Universe" tactile exhibition, including 3D models of celestial bodies and telescopes that both blind and visually impaired (BVI) people and sighted people can understand and enjoy. Through the JAPAN Science Museum Association network, science museums in Japan can easily borrow it and hold their own tacile exhibition without using a 3D printer. The exhibition set consists of existing 3D models, additional tactile images, scale models of the Solar System. Each model has a concise description panel with both printed and braille letters. This easy-to-use set can be a breakthrough for science museum staff members to hold their own tactile exhibition and communicate with BVI people.
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- 2022
12. Waterfall height sets the mechanism and rate of upstream retreat
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T. Inoue, N. Izumi, J.S. Scheingross, Y. Hiramatsu, S. Tanigawa, and T. Sumner
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Geology - Abstract
Waterfalls are among the fastest-eroding parts of river networks, but predicting natural waterfall retreat rates is difficult due to multiple processes that can drive waterfall erosion. We lack data on how waterfall height influences the mechanism and rate of upstream waterfall retreat. We addressed this knowledge gap with experiments testing the influence of drop height on waterfall retreat. Our experiments showed that shorter waterfalls retreat up to five times faster than taller waterfalls, when bedrock strength, sediment supply, and water discharge are constant. This retreat rate difference is due to a change in the erosion mechanism. Short waterfalls retreat by the formation of several small, rapidly eroding bedrock steps (i.e., cyclic steps), whereas tall waterfalls tend to form large bedrock plunge pools where lateral plunge pool erosion allows headwall undercutting and subsequent waterfall retreat. Because waterfall height can be partially set by the waterfall formation mechanism, our results highlight that the rate of waterfall retreat and subsequent landscape evolution can be modulated by the processes that form waterfalls.
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- 2023
13. Hypertriglyceridaemia-induced pancreatitis
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T Goto, K Ishizuka, Y Kitai, and T Inoue
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General Medicine - Published
- 2023
14. KpFtsZ single filament
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J, Fujita, additional, H, Amesaka, additional, T, Yoshizawa, additional, K, Hibino, additional, N, Kamimura, additional, N, Kuroda, additional, T, Konishi, additional, Y, Kato, additional, M, Hara, additional, T, Inoue, additional, K, Namba, additional, SI, Tanaka, additional, and H, Matsumura, additional
- Published
- 2023
- Full Text
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15. KpFtsZ–Mb double helical tube
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J, Fujita, additional, H, Amesaka, additional, T, Yoshizawa, additional, K, Hibino, additional, N, Kamimura, additional, N, Kuroda, additional, T, Konishi, additional, Y, Kato, additional, M, Hara, additional, T, Inoue, additional, K, Namba, additional, SI, Tanaka, additional, and H, Matsumura, additional
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- 2023
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16. Random non-proportional fatigue tests with planar tri-axial fatigue testing machine
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T. Inoue, R. Nagao, and N. Takeda
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Fatigue ,Non-proportional ,Random ,Plane stress ,Fatigue life prediction ,Testing machine ,Mechanical engineering and machinery ,TJ1-1570 ,Structural engineering (General) ,TA630-695 - Abstract
Complex stresses, which occur on the mechanical surfaces of transport machinery in service, bring a drastic degradation in fatigue life. However, it is hard to reproduce such complex stress states for evaluating the fatigue life with conventional multiaxial fatigue machines. We have developed a fatigue testing machine that enables reproduction of such complex stresses. The testing machine can reproduce arbitrary in-plane stress states by applying three independent loads to the test specimen using actuators which apply loads in the 0, 45, and 90 degree directions. The reproduction was tested with complex stress data obtained from the actual operation of transport machinery. As a result, it was found that the reproduced stress corresponded to the measured stress with an error range of less than 10 %. Then, we made a comparison between measured fatigue lives under random non-proportional loading conditions and predicted fatigue lives. It was found that predicted fatigue lives with cr, stress on critical plane, were over a factor of 10 against measured fatigue lives. On the other hand, predicted fatigue lives with ma, stress in consideration of a non-proportional level evaluated by using amplitude and direction of principal stress, were within a factor of 3 against measured fatigue lives
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- 2016
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17. Isoprothiolane advances improvement of color through gibberellic acid metabolism in satsuma mandarin (Citrus unshiu Marc.)
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Satoru Kondo, Hiroyuki Tomiyama, Risa Oda, Takanori Saito, Katsuya Ohkawa, Hitoshi Ohara, S Aramaki, T Inoue, and Takashi Ohtsuka
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Physiology ,Plant Science ,Agronomy and Crop Science - Abstract
The functions of isoprothiolane (IPT), which is a fungicide against rice blast, in carotenoid accumulation were examined in satsuma mandarin fruit (Citrus unshiu Marc). Whole trees were treated with IPT at 25 days before harvest. Concentrations of gibberellic acid-1 (GA1) and GA4 in the flavedo of IPT-treated trees were significantly decreased at 5 days after treatment (DAT) compared to the untreated control. The expressions of CitGA20ox1 in IPT-treated flavedo were lower than those in the untreated controls at 5 and 25 DAT. The CitGA3ox expressions in IPT-treated flavedo were lower than those in the untreated control at 5 DAT. ABA concentrations in IPT-treated flavedo were significantly higher than those in the untreated control at 25 DAT. The concentrations of b-cryptoxanthin in IPT-treated flavedo were higher than those in the untreated control at 25 DAT. The chlorophyll concentrations of IPT-treated flavedo were lower than those in the untreated control at 5 and 20 DAT. These results suggest that IPT advances b-cryptoxanthin accumulation through the regulation of endogenous GA1 and GA4 based on the inhibition of CitGA20ox1 and CitGA3ox expressions. It is possible that IPT can be utilized to improve coloration in other citrus fruit.
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- 2023
18. Application of genetic algorithms for parameters identification in a developing smart gear system
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T. T. Mac, D. Iba, Y. Matsushita, S. Mukai, T. Inoue, A. Fukushima, N. Miura, T. Iizuka, A. Masuda, and I. Moriwaki
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General Engineering - Published
- 2022
19. Concentrations, loads and yields of organic carbon from two tropical peat swamp forest streams in Riau Province, Sumatra, Indonesia
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H.M. Yupi, T. Inoue, J. Bathgate, and R. Putra
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carbon leaching ,DOC ,fluvial carbon ,TOC ,tropical peatland ,Ecology ,QH540-549.5 - Abstract
Tropical peat swamp forest (PSF) stores large quantities of carbon. To estimate how much organic C is released from this type of landscape we determined organic carbon (C) concentrations, loads and yields in two contrasting watercourses draining from PSF in Riau Province, Sumatra (Indonesia). Meranti Ditch (MD) is an artificial watercourse whose small catchment (estimated area 4.8 km2) is in semi-intact condition, whereas Turip River (TR) has a large natural catchment (estimated area 458 km2) covered with fairly intact PSF where > 75 % of the original canopy trees remain. The organic C load (Gg C yr-1) of each watercourse was calculated by combining TOC concentration with water discharge rate to give organic C yield (g C m-2 yr-1). Dissolved organic carbon (DOC) was the dominant (95.0–99.8 %) component of total organic carbon (TOC) in the water. TOC concentration was 85–94 mg C L-1 in MD and 50–58 mg C L-1 in TR. The high concentration in MD was not surprising because this catchment had been disturbed by repeated phases of logging and a dense network of ditches was excavated ten years ago. The TOC loads were 0.23 Gg C yr-1 in MD and 14.0 Gg C yr-1 in TR. TOC yields (i.e. TOC fluxes through the fluvial system) were 41.6–55.5 g C m-2 yr-1 in MD and 26.2–34.9 g C m-2 yr-1 in TR.
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- 2016
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20. GroEL on Quantifoil grid
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J, Fujita, additional, F, Makino, additional, H, Asahara, additional, M, Moriguchi, additional, S, Kumano, additional, I, Anzai, additional, J, Kishikawa, additional, Y, Matsuura, additional, T, Kato, additional, K, Namba, additional, and T, Inoue, additional
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- 2022
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21. A Value-of-Information Framework for Personalizing the Timing of Surveillance Testing
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Charles J. Wolock, Aasthaa Bansal, David L. Veenstra, Anirban Basu, Lurdes Y. T. Inoue, and Patrick J. Heagerty
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medicine.medical_specialty ,Dynamic prediction ,business.industry ,Cost-Benefit Analysis ,Health Policy ,Disease progression ,Uncertainty ,Article ,Value of information ,Neoplasms ,Disease Progression ,Humans ,Biomarker (medicine) ,Medicine ,Personalized medicine ,business ,Intensive care medicine ,Biomarkers - Abstract
Background Patient surveillance using repeated biomarker measurements presents an opportunity to detect and treat disease progression early. Frequent surveillance testing using biomarkers is recommended and routinely conducted in several diseases, including cancer and diabetes. However, frequent testing involves tradeoffs. Although surveillance tests provide information about current disease status, the complications and costs of frequent tests may not be justified for patients who are at low risk of progression. Predictions based on patients’ earlier biomarker values may be used to inform decision making; however, predictions are uncertain, leading to decision uncertainty. Methods We propose the Personalized Risk-Adaptive Surveillance (PRAISE) framework, a novel method for embedding predictions into a value-of-information (VOI) framework to account for the cost of uncertainty over time and determine the time point at which collection of biomarker data would be most valuable. The proposed sequential decision-making framework is innovative in that it leverages the patient’s longitudinal history, considers individual benefits and harms, and allows for dynamic tailoring of surveillance intervals by considering the uncertainty in current information and estimating the probability that new information may change treatment decisions, as well as the impact of this change on patient outcomes. Results When applied to data from cystic fibrosis patients, PRAISE lowers costs by allowing some patients to skip a visit, compared to an “always test” strategy. It does so without compromising expected survival, by recommending less frequent testing among those who are unlikely to be treated at the skipped time point. Conclusions A VOI-based approach to patient monitoring is feasible and could be applied to several diseases to develop more cost-effective and personalized strategies for ongoing patient care. Highlights In many patient-monitoring settings, the complications and costs of frequent tests are not justified for patients who are at low risk of disease progression. Predictions based on patient history may be used to individualize the timing of patient visits based on evolving risk. We propose Personalized Risk-Adaptive Surveillance (PRAISE), a novel method for personalizing the timing of surveillance testing, where prediction modeling projects the disease trajectory and a value-of-information (VOI)–based pragmatic decision-theoretic framework quantifies patient- and time-specific benefit-harm tradeoffs. A VOI-based approach to patient monitoring could be applied to several diseases to develop more personalized and cost-effective strategies for ongoing patient care.
- Published
- 2021
22. Rivaroxaban Monotherapy in Patients With Atrial Fibrillation After Coronary Stenting
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Tetsuya Matoba, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa, Yukihiro Koretsune, Takafumi Hiro, Tetsuya Sumiyoshi, Kazumi Kimura, Yoichiro Hashimoto, Teruyuki Hirano, Hiroyuki Daida, Yasushi Okada, Tsutomu Yamazaki, A. Nakamura, E. Tamiya, T. Yamamoto, S. Suetake, T. Noguchi, S. Nakamura, A. Matsumura, J. Kojima, S. Suwa, H. Yamaguchi, K. Kaikita, T. Yasu, A. Nakajima, T. Yamada, H. Arai, Y. Hata, T. Sakanashi, H. Tateishi, T. Nakayama, Y. Nozaki, M. Akao, Y. Okumura, M. Tokue, N. Kuroki, Y. Maruyama, T. Matoba, N. Hagiwara, H. Suzuki, Y. Nishida, M. Ajioka, K. Yumoto, S. Shimizu, T. Aoyama, H. Shimomura, T. Takeda, K. Oshiro, N. Sugishita, Y. Shibata, T. Otonari, H. Kihara, H. Ogawa, A. Ohno, M. Hazama, M. Shimizu, K. Tsukahara, S. Haruta, T. Wakeyama, T. Haruna, M. Ito, K. Fujii, N. Atsuchi, M. Sata, K. Kimura, N. Hasebe, Y. Kobayasi, K. Ohsato, K. Hironaga, Y. Naganuma, K. Anzaki, K. Oiwa, S. Okazaki, Y. Nakagawa, K. Tokuhiro, K. Tanaka, T. Momose, Y. Fukushima, R. Kametani, K. Kawamitsu, Y. Saito, S. Akashi, K. Kumagai, K. Eshima, T. Tobaru, T. Seo, K. Okuhara, K. Kozuma, Y. Ikari, T. Takahashi, I. Michishita, H. Fujikura, S. Momomura, Y. Yamamoto, K. Otomo, T. Matsubara, H. Tashiro, T. Inoue, M. Ishihara, I. Shiojima, E. Tachibana, J. Ako, K. Sumii, N. Yamamoto, N. Ohmura, T. Nakamura, Y. Morita, N. Takahashi, K. Watanabe, H. Fujinaga, M. Maruyama, T. Oka, T. Shirayama, T. Amano, K. Fukui, K. Ando, S. Oshima, S. Kagiyama, H. Teragawa, M. Yuge, S. Ono, T. Koga, K. Fujiu, M. Kuwabara, Y. Ohya, Y. Yumoto, N. Kuji, M. Ikemura, K. Kario, K. Chatani, K. Sato, H. Miyagi, M. Murakami, K. Saito, M. Hoshiga, S. Sato, N. Kubo, Y. Sakamoto, K. Ashida, H. Sakamoto, S. Murasaki, H. Uehara, T. Akasaka, Y. Ooba, S. Nakahara, Y. Hanaoka, T. Nishimiya, R. Tsunoda, Y. Onuma, S. Higuchi, A. Tani, A. Wada, M. Kato, H. Obata, Y. Higuchi, T. Endo, R. Katou, T. Matsunaga, T. Matsuoka, H. Noguchi, M. Usui, T. Hayashi, Y. Otsuji, T. Osaki, H. Zaizen, H. Yoshihara, K. Kadota, T. Hirose, T. Miyazawa, A. Mori, M. Takano, W. Shimizu, M. Wake, S. Oriso, M. Yoshiyama, S. Kakinoki, T. Nishioka, T. Ozaki, K. Nomoto, K. Seki, K. Kawai, Y. Ozaki, S. Miura, M. Kawasaki, R. Funada, K. Dote, T. Nagano, S. Okamoto, T. Kubo, Y. Murozono, T. Owada, T. Doke, T. Matsumura, M. Horiuchi, A. Takaishi, M. Yamamoto, H. Nakashima, M. Munemasa, Y. Sakata, N. Inoue, T. Ota, Y. Hamano, N. Abe, T. Tsubokura, M. Goto, I. Kubota, M. Yano, K. Umetani, T. Date, H. Morimoto, T. Noda, S. Goto, K. Hibi, A. Nakano, S. Hiramitsu, Y. Kihara, M. Sugi, N. Shiba, D. Izumi, T. Sato, S. Tayama, T. Matsui, A. Suzuki, K. Ajiki, M. Oishi, M. Kiryu, T. Ko, H. Ando, S. Miyazaki, T. Kinugawa, H. Otake, H. Kitaoka, Y. Hirata, S. Honda, M. Manita, Y. Ishii, H. Oka, Y. Nanba, M. Nishino, T. Sakamoto, T. Saito, H. Sakai, M. Ichikawa, S. Namiuchi, K. Inoue, N. Komiyama, Y. Akashi, Y. Nakamura, T. Komaru, T. Hosokawa, T. Chikamori, H. Tanaka, O. Arasaki, K. Aonuma, Y. Wakasa, T. Yoshizawa, T. Sugano, N. Yokota, A. Kakutani, T. Suzuki, Y. Abe, T. Kataoka, H. Okayama, H. Yokoi, K. Chin, K. Hasegawa, H. Tomita, H. Honzyo, H. Kawai, K. Yamamoto, Y. Morino, S. Tsujiyama, S. Hamasaki, Y. Niijima, Y. Mizuno, A. Maki, K. Tanabe, T. Murohara, S. Naomi, M. Arikawa, T. Kato, N. Matsumoto, T. Minamino, H. Sairenji, N. Miyamoto, H. Ito, Y. Matsuura, S. Hata, Y. Nakatsu, T. Onodera, M. Yoshimura, H. Amano, E. Tokutake, M. Kasao, M. Moriguchi, M. Tsuji, H. Yamamoto, Y. Yanbe, T. Iwasawa, M. Suzuki, and H. Mori
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Rivaroxaban ,medicine.medical_specialty ,business.industry ,Unstable angina ,medicine.medical_treatment ,Percutaneous coronary intervention ,Atrial fibrillation ,medicine.disease ,Thrombosis ,Coronary artery disease ,Internal medicine ,medicine ,Cardiology ,cardiovascular diseases ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,business ,Stroke ,medicine.drug - Abstract
Objectives The aim of this AFIRE (Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease) trial subgroup analysis was to examine rivaroxaban monotherapy benefits and their relation to the time between stenting and enrollment among patients after coronary stenting. Background Of 2,215 patients with atrial fibrillation and stable coronary artery disease in the AFIRE trial, rivaroxaban monotherapy was noninferior to rivaroxaban plus antiplatelet therapy (combination therapy) in terms of efficacy and superior for safety endpoints. However, thrombotic risk after antiplatelet therapy cessation remained a concern among 1,444 patients who had undergone coronary stenting >1 year before enrollment. Methods The benefits of rivaroxaban monotherapy in coronary stenting subgroups were assessed for efficacy (a composite of stroke, systemic embolism, myocardial infarction, unstable angina requiring revascularization, or death of any cause), safety (major bleeding defined according to International Society on Thrombosis and Haemostasis criteria), ischemic endpoints, net adverse clinical event, and time between stenting and enrollment. Results Efficacy and safety endpoints for monotherapy were superior to combination therapy, with HRs of 0.70 for efficacy (95% CI: 0.50-0.98; P = 0.036) and 0.55 for safety (95% CI: 0.33-0.92; P = 0.019). For ischemic endpoints, the HR was 0.82 (95% CI: 0.58-1.15; P = 0.240). The HR became smaller with longer time between stenting and enrollment (efficacy, P for interaction = 0.158; safety, P = 0.097). Conclusions In patients with atrial fibrillation after coronary stenting, the benefits of rivaroxaban monotherapy for efficacy and safety endpoints were consistent with those in the whole AFIRE trial population. The benefits became apparent with longer time between stenting and enrollment. (Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study [AFIRE]; UMIN000016612 , NCT02642419 )
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- 2021
23. WCN23-0404 SYNERGISTIC ANTI-INFLAMMATORY AND RENAL PROTECTIVE MECHANISMS MEDIATED BY PARASYMPATHETIC AND SYMPATHETIC NERVOUS STIMULATION VIA IMMUNE SYSTEM
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R. UMENE, C.H. Wu, Y. Nakamura, T. Inoue, and T. Nishino
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Nephrology - Published
- 2023
24. Hounsfield unit in predicting intra and postoperative outcomes in retrograde intrarenal surgery using holmium and thulium fiber laser? Results from multicentre FLEXible ureteroscopy outcomes registry (FLEXOR)
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D. Ragoori, W. Ong Lay Keat, J. Yuen-Chun Teoh, B.H. Chew, T. Inoue, S. More, T. Ahn, S. Biligere, C.A. Chai, M.P. Pavia, K. Sarica, O. Traxer, D. Castellani, B.K. Somani, and V. Gauhar
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Urology - Published
- 2023
25. Comparative study on stone retropulsion using pulse modulation mode in virtual ureter model
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Y. Maruyama, S. Yamashita, Y. Tasaka, T. Inoue, Y. Kohjimoto, T. Matsumura, and I. Hara
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Urology - Published
- 2023
26. Comparison of intrarenal pressure during retrograde intrarenal surgery using various single-use ureteroscopes: An in-vitro study
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S. Yamashita, R. Deguchi, Y. Iwahashi, M. Higuchi, T. Inoue, Y. Kohjimoto, and I. Hara
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Urology - Published
- 2023
27. Application of a global nonhydrostatic model with a stretched-grid system to regional aerosol simulations around Japan
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D. Goto, T. Dai, M. Satoh, H. Tomita, J. Uchida, S. Misawa, T. Inoue, H. Tsuruta, K. Ueda, C. F. S. Ng, A. Takami, N. Sugimoto, A. Shimizu, T. Ohara, and T. Nakajima
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Geology ,QE1-996.5 - Abstract
An aerosol-coupled global nonhydrostatic model with a stretched-grid system has been developed. Circulations over the global and target domains are simulated with a single model, which includes fine meshes covering the target region to calculate meso-scale circulations. The stretched global model involves lower computational costs to simulate atmospheric aerosols with fine horizontal resolutions compared with a global uniform nonhydrostatic model, whereas it may require higher computational costs compared with the general regional models, because the stretched-grid system calculates inside and outside the target domain. As opposed to general regional models, the stretched-grid system requires neither a nesting technique nor lateral boundary conditions. In this study, we developed a new-type regional model for the simulation of aerosols over Japan, especially in the Kanto areas surrounding Tokyo, with a maximum horizontal resolution of approximately 10 km. This model usually reproduces temporal variations and their averages of the observed weather around Japan. This model generally reproduces monthly mean distributions of the observed sulfate and SO2 over East Asia, with high correlations (R > 0.6), but the underestimation of the simulated concentrations by 40% (sulfate) and 50% (SO2). Their underestimation of the simulated sulfate and SO2 concentrations over East Asia are strongly affected by their underestimation in China and possibly by the uncertainty of the simulated precipitation around Japan. In the Kanto area, this model succeeds in simulating the wind patterns and the diurnal transitions around the center of the Kanto area, although it is inadequate to simulate the wind patterns and the diurnal transitions at some sites located at the edge of the Kanto area and surrounded on three sides by mountains, e.g., Maebashi, mainly due to the insufficient horizontal resolution. This model also generally reproduces both diurnal and synoptic variations of the observed and/or a regional aerosol-transport model, WRF-CMAQ, simulated EC, sulfate, and SO2 concentrations in the Kanto area, especially with their high correlation (R > 0.5) at Komae/Tokyo. Although the aerosol module used in this study is relatively simplified compared to the general regional aerosol models, this study reveals that our proposed model with the stretched-grid system can be applicable for the regional aerosol simulation.
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- 2015
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28. GroEL on EG-grid stored for 3 months after graphene oxidation
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J, Fujita, additional, F, Makino, additional, H, Asahara, additional, M, Moriguchi, additional, S, Kumano, additional, I, Anzai, additional, J, Kishikawa, additional, Y, Matsuura, additional, T, Kato, additional, K, Namba, additional, and T, Inoue, additional
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- 2022
- Full Text
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29. 394P Research of the algorithm for rare driver genes in non-small cell lung cancer using pathological images and artificial intelligence
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K. Yoh, S. Matsumoto, Y. Sugawara, Y. Hirano, J. Iwasawa, T. Inoue, K. Mizuno, W. Kochi, M. Amamoto, D. Maeda, and K. Goto
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Oncology ,Hematology - Published
- 2022
30. P-185 The migration speed of nucleolar precursor bodies in pronuclei affects in vitro fertilization-derived human embryo ploidy status
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T Inoue, S Taguchi, M Uemura, Y Tsujimoto, and Y Yamashita
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Reproductive Medicine ,Rehabilitation ,Obstetrics and Gynecology - Abstract
Study question Does the migration speed of nucleolar precursor bodies (NPBs) in male and female pronuclei (mPN and fPN) affect in vitro fertilization (IVF)-derived embryo ploidy status? Summary answer The NPB migration speed in mPN impacts the IVF-derived human embryo ploidy status and this indicator could be an attractive marker for noninvasive embryo selection. What is known already NPBs are not considered as simple nucleolar components transmitted from an oocyte to an embryo, and they could participate in genome remodeling during embryo development. NPBs are essential only shortly after fertilization, suggesting that they may actively participate in centromeric chromatin establishment. A previous study demonstrated that NPBs migrated faster in intracytoplasmic sperm injection-derived zygotes having the potential to develop into a blastocyst and eventually into a baby (Inoue et al., 2021). However, the relationship between NPB migration speed and IVF-derived embryo ploidy status is unclear. Study design, size, duration The relationship between the NPB migration speed and embryo ploidy status was retrospectively analyzed in patients with recurrent assisted reproductive technology failure (euploid n =18; aneuploid n =19; and total = 219 NPBs). Archived time-lapse videos (images were recorded every 5 min; Geri+) from incubation after IVF were retrieved after the patients were identified for the study, and the NPB migration speed was analyzed. The retrospective analyses were performed with the patient’s identities masked. Participants/materials, setting, methods mPN and fPN were identified by appearance location in a zygote (fPN appearance is just below the polar bodies). The mPN, fPN, and 2–3 NPBs/PN central coordinates were measured by Kinovea (motion capture software). Their central coordinates were confirmed/revised every image and were decided. The migration distance of NPBs between two sequential images was calculated as the standard of the central PN coordinates. Thereafter, the migration speed of NPBs was calculated. Main results and the role of chance Both NPB speeds were significantly faster in the euploid than in the aneuploid groups (mPN: 4.08±0.61 vs. 3.54±0.54 µm/h, P =0.003, power [1-β]: 0.999, fPN: 4.03±0.89 vs. 3.26±0.45 µm/h, P Limitations, reasons for caution The NPB migration in the z-axis direction could not be analyzed. NPB tracking could not be performed when NPBs were large in number or drastically moved. Our findings should help in elucidating the relationship, although they did not completely explain the relationship between NPB migration and embryo development. Wider implications of the findings The migration speed of NPBs impacts human embryo ploidy status. NPB migration speed may add clinical value for embryo selection, which may be associated with live birth, and consequently, the time of the live birth could be shorter. The indicator could be an attractive marker for noninvasive embryo selection. Trial registration number Not applicable
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- 2022
31. Simplified Improvement of Higher Order Extended Bulk Flow Analysis Specialized for Derivation of Rotordynamic Coefficients of the Annular Plain Seal With Large Static Eccentricity
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T. Inoue and K. Yamada
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Control and Systems Engineering ,Applied Mathematics ,Mechanical Engineering ,General Medicine - Abstract
Rotordynamic (RD) fluid force of turbomachinery is known as one of the causes of the shaft vibration problem. Bulk flow analysis is the analytical method of RD fluid force, and it is widely used in design stage. Conventional bulk flow analysis has been basically carried out under the assumption of concentric circular whirl orbit. While, the actual turbomachinery is often operated with static eccentricity due to the effect of static load and so on. However, there are not many studies that have investigated the case with large static eccentricity, in particular, the case more than half the seal clearance. In this paper, the linear RD coefficient for the plain annular seal is focused on and examined for the range that static eccentricity is up to 65% of seal clearance. In this range of static eccentricity, it requires the nonlinear analysis extended to the fifth order and largely increases the number of equations to be solved. This paper proposed simplification of higher order extended bulk flow (SHEBF) analysis, and as a result, the number of analytical equations to be solved is significantly reduced. The validity of this method is confirmed both numerically and experimentally.
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- 2022
32. Takayasu's Arteritis with Symptomatic Brachiocephalic Artery Stenosis and Left Common Carotid Artery Occlusion Undergoing Partial Arch Replacement after Coronary Artery Bypass Grafting
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Kenji Okada, Mari Hamaguchi, Soichiro Henmi, Hidekazu Nakai, Katsuhiro Yamanaka, Takeshi Inoue, Takanori Tsujimoto, Yu Murakami, Atsushi Omura, and T. Inoue
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medicine.medical_specialty ,Bypass grafting ,business.industry ,Takayasu's arteritis ,medicine.disease ,Stenosis ,medicine.anatomical_structure ,Internal medicine ,medicine.artery ,Occlusion ,medicine ,Brachiocephalic artery ,Cardiology ,Common carotid artery ,business ,Artery - Published
- 2021
33. High-speed Construction of Large-section, Great-depth, Long-distance Shield Using RC Segments with Fire Resistance
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A. Ehara, J. Takahashi, and T. Inoue
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General Materials Science - Published
- 2021
34. Gas exchange of root hemi-parasite Striga hermonthica and its host Sorghum bicolor under short-term soil water stress
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T. Inoue, Y. Yamauchi, A. H. Eltayeb, H. Samejima, A. G. T. Babiker, and Y. Sugimoto
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drought ,host-parasite interaction ,net photosynthetic rate ,relative water content ,respiration rate ,stomatal conductance ,transpiration rate ,Biology (General) ,QH301-705.5 ,Plant ecology ,QK900-989 - Abstract
The gas exchange of the upper fully expanded leaf of the root parasite Striga hermonthica and of its host Sorghum bicolor was measured under wet and dry conditions to identify the mechanisms of the devastating effects of the parasite on its hosts under drought. The short-term water stress severely reduced photosynthetic rate in infected sorghum, but less in S. hermonthica. Soil water stress did not affect leaf respiration rate in either S. hermonthica or infected sorghum. This suggests that under dry conditions both infected sorghum and S. hermonthica decreased autotrophic carbon gain. The transpiration rate of S. hermonthica, a major driving force for assimilate uptake from the host, was higher and less affected by water stress than that of infected sorghum. Stomatal density on the abaxial surfaces of the leaves was higher in S. hermonthica than in sorghum. Both S. hermonthica infection and water stress decreased stomatal conductance of the sorghum leaves. S. hermonthica, irrespective of soil water status, had greater stomatal aperture on the adaxial and abaxial surfaces of its leaves than infected sorghum. These results indicate that the higher transpiration rate of S. hermonthica even under water stress, achieved through higher stomatal density on the abaxial surfaces of the leaves and greater stomatal aperture on both surfaces of the leaves, may induce the maintenance of water and solute transfers from the host to the parasite leading to severe damage to the host under drought.
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- 2013
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35. Late-onset hypogonadism is one of an important cause of anemia in male hemodialysis patients
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T. Ando, K. Murakami, D. Miki, Y. Fujita, T. Ishikawa, S. Suzuki, S. Abe, K. Iwasaki, M. Shinohara, Y. Sato, S. Sejiyama, S. Hata, T. Inoue, T. Shibuya, and T. Shin
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Urology - Published
- 2023
36. Comparison of Patency in 5- and 6-mm Hemodialysis Grafts
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Y. Tasaki, T. Inoue, T. Odate, Y. Hisata, and T. Yamada
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03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,medicine.medical_treatment ,030232 urology & nephrology ,Medicine (miscellaneous) ,Medicine ,Hemodialysis ,030204 cardiovascular system & hematology ,business ,Surgery - Abstract
Highlights Abstract Objectives: Arteriovenous grafts (AVGs) are often the mode of vascular access of choice because poor blood vessels in patients hinder the creation of arteriovenous fistulas (AVFs). The present study aimed to compare the characteristics and patency rates between 5-mm and 6-mm straight grafts. Methods: We analyzed 119 cases involving AVG operations performed at a single center. The cases were divided into 2 groups based on the size of the straight graft, namely 5-mm (62.2%) and 6-mm (37.8%) grafts. The differences in the baseline characteristics, perioperative data, and patency rates between the groups were subsequently analyzed. Results: Patients who received 5-mm grafts were predominantly female (P = 0.042) and had a higher body mass index (BMI; P = 0.012) than those who received 6-mm grafts. The 5-mm graft group showed increased primary patency (P = 0.035). However, significant intergroup differences were not observed with respect to the secondary patency rates (P = 0.087). A multivariable analysis confirmed that higher BMI (P = 0.022), cause of diabetes mellitus nephropathy (P = 0.015), frequency of the procedure (≥5 times; P = 0.002), and procedure time (P = 0.028) were significant independent variables that affected the primary patency rates. Conclusions: Five-mm grafts were associated with higher BMI, female predominance, and increased primary patency compared with the 6-mm grafts. Therefore, 5-mm grafts should be considered for patients with poor blood vessels.
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- 2020
37. EP05.02-017 Prognostic Factors Following Induction Therapy for N2 Lung Cancer
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T. Inoue, Y. Tokuda, T. Aruga, S. Umeda, Y. Yazaki, S. Imamura, A. Nomura, O. Araki, T. Nakajima, S. Maeda, and M. Chida
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Pulmonary and Respiratory Medicine ,Oncology - Published
- 2022
38. Predictive Relations between Pre-discharge APIB Scores and Post-term General Movement (GM) Assessment in Very Low Birth Weight Infants
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T Fujimoto, A Ogaki, T Inoue, T Kawai, M Tanaka, M Kugo, and J Browne
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- 2022
39. Choice of 16S ribosomal RNA primers impacts urinary microbiota profiling
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Vitor Heidrich, Lilian T. Inoue, Paula F. Asprino, Fabiana Bettoni, Antonio C.H. Mariotti, Diogo A. Bastos, Denis L.F. Jardim, Marco A. Arap, and Anamaria A. Camargo
- Abstract
Accessibility to next-generation sequencing (NGS) technologies has enabled the profiling of microbial communities living in distinct habitats. 16S ribosomal RNA (rRNA) gene sequencing is widely used for microbiota profiling with NGS technologies. Since most used NGS platforms generate short reads, sequencing the full-length 16S rRNA gene is impractical. Therefore, choosing which 16S rRNA hypervariable region to sequence is critical in microbiota profiling studies. All nine 16S rRNA hypervariable regions are taxonomically informative, but due to variability in profiling performance for specific clades, choosing the ideal 16S rRNA hypervariable region will depend on the bacterial composition of the habitat under study. Recently, NGS allowed the identification of microbes in the urinary tract, and urinary microbiota has become an active research area. However, there is no current study evaluating the performance of different 16S rRNA hypervariable regions for urinary microbiota profiling. We collected urine samples from male volunteers and profiled their urinary microbiota by sequencing a panel of six amplicons encompassing all nine 16S rRNA hypervariable regions. After systematically comparing their performance, we show that V1V2 hypervariable regions better assess the taxa commonly present in urine samples and V1V2 amplicon sequencing is more suitable for urinary microbiota profiling. We believe our results will be helpful to guide this crucial methodological choice in future urinary microbiota studies.
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- 2022
40. Choice of 16S Ribosomal RNA Primers Impacts Male Urinary Microbiota Profiling
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Vitor Heidrich, Lilian T. Inoue, Paula F. Asprino, Fabiana Bettoni, Antonio C. H. Mariotti, Diogo A. Bastos, Denis L. F. Jardim, Marco A. Arap, and Anamaria A. Camargo
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Microbiology (medical) ,Male ,Infectious Diseases ,Bacteria ,Microbiota ,RNA, Ribosomal, 16S ,Immunology ,High-Throughput Nucleotide Sequencing ,Humans ,Sequence Analysis, DNA ,Microbiology ,Phylogeny ,DNA Primers - Abstract
Accessibility to next-generation sequencing (NGS) technologies has enabled the profiling of microbial communities living in distinct habitats. 16S ribosomal RNA (rRNA) gene sequencing is widely used for microbiota profiling with NGS technologies. Since most used NGS platforms generate short reads, sequencing the full-length 16S rRNA gene is impractical. Therefore, choosing which 16S rRNA hypervariable region to sequence is critical in microbiota profiling studies. All nine 16S rRNA hypervariable regions are taxonomically informative, but due to variability in profiling performance for specific clades, choosing the ideal 16S rRNA hypervariable region will depend on the bacterial composition of the habitat under study. Recently, NGS allowed the identification of microbes in the urinary tract, and urinary microbiota has become an active research area. However, there is no current study evaluating the performance of different 16S rRNA hypervariable regions for male urinary microbiota profiling. We collected urine samples from male volunteers and profiled their urinary microbiota by sequencing a panel of six amplicons encompassing all nine 16S rRNA hypervariable regions. Systematic comparisons of their performance indicate V1V2 hypervariable regions better assess the taxa commonly present in male urine samples, suggesting V1V2 amplicon sequencing is more suitable for male urinary microbiota profiling. We believe our results will be helpful to guide this crucial methodological choice in future male urinary microbiota studies.
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- 2022
41. Cherenkov Telescope Array : the World’s largest VHE gamma-ray observatory
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Roberta Zanin, H. Abdalla, H. Abe, S. Abe, A. Abusleme, F. Acero, A. Acharyya, V. Acin Portella, K. Ackley, R. Adam, C. Adams, S.S. Adhikari, I. Aguado Ruesga, I. Agudo, R. Aguilera, A. Aguirre Santaella, F. Aharonian, A. Alberdi, R. Alfaro, J. Alfaro, C. Alispach, R. Aloisio, R. Alves Batista, J.P. Amans, L. Amati, E. Amato, L. Ambrogi, G. Ambrosi, M. Ambrosio, R. Ammendola, J. Anderson, M. Anduze, E.O. Anguner, L.A. Antonelli, V. Antonuccio, P. Antoranz, R. Anutarawiramkul, J. Aragunde Gutierrez, C. Aramo, A. Araudo, M. Araya, A. Arbet Engels, C. Arcaro, V. Arendt, C. Armand, T. Armstrong, F. Arqueros, L. Arrabito, B. Arsioli, M. Artero, K. Asano, Y. Ascasibar, J. Aschersleben, M. Ashley, P. Attina, P. Aubert, C. B. Singh, D. Baack, A. Babic, M. Backes, V. Baena, S. Bajtlik, A. Baktash, C. Balazs, M. Balbo, O. Ballester, J. Ballet, B. Balmaverde, A. Bamba, R. Bandiera, A. Baquero Larriva, P. Barai, C. Barbier, V. Barbosa Martins, M. Barcelo, M. Barkov, M. Barnard, L. Baroncelli, U. Barres de Almeida, J.A. Barrio, D. Bastieri, P.I. Batista, I. Batkovic, C. Bauer, R. Bautista González, J. Baxter, U. Becciani, J. Becerra González, Y. Becherini, G. Beck, J. Becker Tjus, W. Bednarek, A. Belfiore, L. Bellizzi, R. Belmont, W. Benbow, D. Berge, E. Bernardini, M.I. Bernardos, K. Bernlöhr, A. Berti, M. Berton, B. Bertucci, V. Beshley, N. Bhatt, S. Bhattacharyya, W. Bhattacharyya, B. Y. Bi, G. Bicknell, N. Biederbeck, C. Bigongiari, A. Biland, R. Bird, E. Bissaldi, J. Biteau, M. Bitossi, O. Blanch, M. Blank, J. Blazek, J. Bobin, C. Boccato, F. Bocchino, C. Boehm, M. Bohacova, C. Boisson, J. Boix, J.P. Bolle, J. Bolmont, G. Bonanno, C. Bonavolontà, L. Bonneau Arbeletche, G. Bonnoli, P. Bordas, J. Borkowski, R. Bose, D. Bose, Z. Bosnjak, E. Bottacini, Markus Böttcher, M.T. Botticella, C. Boutonnet, F. Bouyjou, V. Bozhilov, E. Bozzo, L. Brahimi, C. Braiding, S. Brau Nogue, S. Breen, J. Bregeon, M. Breuhaus, A. Brill, W. Brisken, E. Brocato, A.M. Brown, K. Brügge, P. Brun, F. Brun, L. Brunetti, G. Brunetti, P. Bruno, A. Bruno, A. Bruzzese, N. Bucciantini, J. H. Buckley, R. Bühler, A. Bulgarelli, T. Bulik, M. Bünning, M. Bunse, M. Burton, A. Burtovoi, M. Buscemi, S. Buschjager, G. Busetto, J. Buss, K. Byrum, A. Caccianiga, F. Cadoux, A. Calanducci, C. Calderon, J. Calvo Tovar, R. A. Cameron, P. Campana, R. Canestrari, F. Cangemi, B. Cantlay, M. Capalbi, M. Capasso, M. Cappi, A. Caproni, R. Capuzzo Dolcetta, P. Caraveo, V. Cárdenas, L. Cardiel, M. Cardillo, C. Carlile, S. Caroff, R. Carosi, A. Carosi, E. Carquin, M. Carrere, J.M. Casandjian, S. Casanova, F. Cassol, F. Catalani, O. Catalano, D. Cauz, A. Ceccanti, C. Celestino Silva, K. Cerny, M. Cerruti, E. Chabanne, P. Chadwick, Y. Chai, P. Chambery, C. Champion, S. Chaty, A. Chen, K. Cheng, M. Chernyakova, G. Chiaro, A. Chiavassa, M. Chikawa, V.R. Chitnis, J. Chudoba, L. Chytka, S. Cikota, A. Circiello, P. Clark, M. Colak, E. Colombo, S. Colonges, A. Comastri, A. Compagnino, V. Conforti, E. Congiu, R. Coniglione, J. Conrad, F. Conte, J.L. Contreras, P. Coppi, R. Cornat, J. Coronado Blazquez, J. Cortina, A. Costa, H. Costantini, G. Cotter, B. Courty, S. Covino, S. Crestan, P. Cristofari, R. Crocker, J. Croston, K. Cubuk, O. Cuevas, X. Cui, G. Cusumano, S. Cutini, G. D'Amico, F. D'Ammando, P. D'Avanzo, P. Da Vela, M. Dadina, S. Dai, M. Dalchenko, M. Dall'Ora, M.K. Daniel, J. Dauguet, I. Davids, J. Davies, B. Dawson, A. De Angelis, A.E. de Araujo Carvalho, M. de Bony de Lavergne, G. De Cesare, F. de Frondat, I. de la Calle, E. de Gouveia Dal Pino, B. De Lotto, A. De Luca, D. De Martino, M. de Naurois, E. de Ona Wilhelmi, F. De Palma Persio, N. De Simone, V. de Souza Valle, E. Delagnes, G. Deleglise Reznicek, C. Delgado, A.G. Delgado Giler, J. Delgado Mengual Valle, Domenico Della Volpe, D. Depaoli, J. Devin, T. Di Girolamo, C. Di Giulio Pierro, L. Di Venere, C. Díaz, C. Dib, S. Diebold, S. Digel, A. Djannati Atai, J. Djuvsland, A. Dmytriiev, K. Docher, A. Domínguez, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, Rita Cassia dos Anjos, J.L. Dournaux, T. Downes, G. Drake, H. Drass, D. Dravins, C. Duangchan, A. Duara, G. Dubus, L. Ducci, C. Duffy, D. Dumora, K. Dundas Mora, A. Durkalec, V.V. Dwarkadas, J. Ebr, C. Eckner, J. Eder, E. Edy, K. Egberts, S. Einecke, C. Eleftheriadis, D. Elsässer, G. Emery, D. Emmanoulopoulos, J.P. Ernenwein, M. Errando, P. Escarate, J. Escudero, C. Espinoza, S. Ettori, A. Eungwanichayapant, P. Evans, C. Evoli, M. Fairbairn, D. Falceta Goncalves, A. Falcone, V. Fallah Ramazanı, R. Falomo, K. Farakos, G. Fasola, A. Fattorini, Y. Favre, R. Fedora, E. Fedorova, K. Feijen, Q. Feng, G. Ferrand, G. Ferrara, O. Ferreira, M. Fesquet, E. Fiandrini, A. Fiasson, M. Filipovic, D. Fink, J.P. Finley, V. Fioretti, D.F.G. Fiorillo, M. Fiorini, S. Flis, H. Flores, L. Foffano, C. Fohr, M.V. Fonseca, L. Font, G. Fontaine, O. Fornieri, P. Fortin, L. Fortson, N. Fouque, B. Fraga, A. Franceschini, F.J. Franco, L. Freixas Coromina, L. Fresnillo, D. Fugazza, Y. Fujita, S. Fukami, Y. Fukazawa, D. Fulla, S. Funk, A. Furniss, S. Gabici, D. Gaggero, G. Galanti, P. Galdemard, Y. A. Gallant, D. Galloway, S. Gallozzi, V. Gammaldi, R. Garcia, L. E. García-Muñoz, E. Garcia Lopez, F. Gargano, C. Gargano, S. Garozzo, D. Gascon, T. Gasparetto, D. Gasparrini, H. Gasparyan, M. Gaug, N. Geffroy, A. Gent, S. Germani, A. Ghalumyan, A. Ghedina, G. Ghirlanda, F. Gianotti, S. Giarrusso, M. Giarrusso, G. Giavitto, B. Giebels, N. Giglietto, V. Gika, F. Gillardo, R. Gimenes, F. Giordano, E. Giro, M. Giroletti, Andrea Giuliani, M. Gjaja, J.F. Glicenstein, P. Gliwny, H. Goksu, P. Goldoni, J.L. Gomez, M.M. Gonzalez, Juan Manuel Gonzalez, K.S. Gothe, D. Gotz Coelho, T. Grabarczyk, R. Graciani, P. Grandi, G. Grasseau, D. Grasso, D. Green, J. Green, T. Greenshaw, P. Grespan, A. Grillo, M.H. Grondin, J. Grube, V. Guarino, B. Guest, O. Gueta, M. Günduz, S. Gunji, G. Gyuk, J. Hackfeld, D. Hadasch, L. Hagge, A. Hahn, J.E. Hajlaoui, A. Halim, P. Hamal, W. Hanlon, Y. Harada, M.J. Hardcastle, M. Harvey Collado, T. Haubold, A. Haupt, M. Havelka, K. Hayashi, M. Hayashida, H. He, L. Heckmann, M. Heller, F. Henault, Gilles Henri, G. Hermann, S. Hernández Cadena, J. Herrera Llorente, O. Hervet, J. Hinton, A. Hiramatsu, K. Hirotani, B. Hnatyk, R. Hnatyk, J.K. Hoang, D. H.H. Hoffmann, C. Hoischen, J. Holder, M. Holler, B. Hona, D. Horan, Dieter Horns, P. Horvath, J. Houles, M. Hrabovsky, D. Hrupec, Y. Huang, J.‑M. Huet, G. Hughes, G. Hull, T.B. Humensky, M. Hütten, M. Iarlori, J.M. Illa, R. Imazawa, T. Inada, F. Incardona, A. Ingallinera, S. Inoue, T. Inoue, Y. Inoue, F. Iocco, K. Ioka, M. Ionica, S. Iovenitti, A. Iriarte, K. Ishio, W. Ishizaki, Y. Iwamura, J. Jacquemier, M. Jacquemont, M. Jamrozy, P. Janecek, F. Jankowsky, A. JardinBlicq, C. Jarnot, P. Jean Martínez, L. Jocou, N. Jordana, M. Josselin, I. JungRichardt, F.J.P.A. Junqueira, C. Juramy Gilles, P. Kaaret, L.H.S. Kadowaki, M. Kagaya, R. Kankanyan, D. Kantzas, V. Karas, A. Karastergiou, S. Karkar, J. Kasperek, H. Katagiri, J. Kataoka, K. Katarzynski, S. Katsuda, N. Kawanaka, D. Kazanas, D. Kerszberg, B. Khélifi, M.C. Kherlakian, T.P. Kian, D.B. Kieda, T. Kihm, S. Kim, S. Kisaka, R. Kissmann, R. Kleijwegt, G. Kluge, W. Kluźniak, J. Knapp, A. Kobakhidze, Y. Kobayashi, B. Koch, J. Kocot, K. Kohri, N. Komin, A. Kong, K. Kosack, F. Krack, M. Krause, F. Krennrich, H. Kubo, V. N. Kudryavtsev, S. Kunwar, J. Kushida, P. Kushwaha, Barbera Parola, G. La Rosa, R. Lahmann, A. Lamastra, M. Landoni, D. Landriu, R.G. Lang, J. Lapington, P. Laporte, P. Lason, J. Lasuik, J. Lazendic Galloway, T. Le Flour, P. Le Sidaner, S. Leach, S.H. Lee, W.H. Lee, S. Lee Oliveira, A. Lemiere, M. Lemoine Goumard, J.P. Lenain, F. Leone, V. Leray, G. Leto, F. Leuschner, R. Lindemann, E. Lindfors, L. Linhoff, I. Liodakis, A. Lipniacka, M. Lobo, Thomas Lohse, S. Lombardi, A. Lopez, M. Lopez, R. Lopez Coto, F. Louis, M. Louys, F. Lucarelli, H. Ludwig Boudi, P.L. Luque Escamilla, M.C. Maccarone, E. Mach, A.J. Maciejewski, J. Mackey, P. Maeght, C. Maggio, G. Maier, P. Majumdar, M. Makariev, M. Mallamaci, R. Malta Nunes de Almeida, D. Malyshev, D. Mandat, G. Maneva, M. Manganaro, P. Manigot, K. Mannheim, N. Maragos, D. Marano, M. Marconi, A. Marcowith, M. Marculewicz, B. Marcun, J. Marin, N. Marinello, P. Marinos, S. Markoff, P. Marquez, G. Marsella, J. M. Martin, P. G. Martin, M. Martinez, G. Martinez, O. Martinez, H. Martinez Huerta, C. Marty, R. Marx, N. Masetti, P. Massimino, H. Matsumoto, N. Matthews, G. Maurin, W. Max Moerbeck, N. Maxted, M.N. Mazziotta, S.M. Mazzola, J.D. Mbarubucyeye, L. Mc Comb, I. McHardy, S. McKeague, S. McMuldroch, E. Medina, D. Medina Miranda, A. Melandri, C. Melioli, D. Melkumyan, S. Menchiari, S. Mereghetti, G. Merino Arevalo, E. Mestre, J.L. Meunier, T. Meures, S. Micanovic, M. Miceli, M. Michailidis, J. Michalowski, T. Miener, I. Mievre, J. D. Miller, T. Mineo, M. Minev, J.M. Miranda, A. Mitchell, T. Mizuno, B. A. Mode, R. Moderski, L. Mohrmann, E. Molinari, T. Montaruli, I. Monteiro, C. Moore, A. Moralejo, D. Morcuende Parrilla, E. Moretti, K. Mori, P. Moriarty, K. Morik, P. Morris, A. Morselli, K. Mosshammer, R. Mukherjee, J. Muller, C. Mundell, J. Mundet, T. Murach, A. Muraczewski, H. Muraishi, I. Musella, A. Musumarra, A. Nagai, S. Nagataki, T. Naito, T. Nakamori, K. Nakashima, K. Nakayama, N. Nakhjiri, G. Naletto, D. Naumann, L. Nava, M.A. Nawaz, H. Ndiyavala, D. Neise, L. Nellen, R. Nemmen, N. Neyroud, K. Ngernphat, T. Nguyen Trung, L. Nicastro, L. Nickel, J. Niemiec, D. Nieto, C. Nigro, M. Nikołajuk, D. Ninci, K. Noda, Y. Nogami, S. Nolan, R. P. Norris, D. Nosek, M. Nöthe, V. Novotny, S. Nozaki, F. Nunio, P. O'Brien, K. Obara, Y. Ohira, M. Ohishi, S. Ohm, T. Oka, N. Okazaki, A. Okumura, C. Oliver, G. Olivera, B. Olmi, M. Orienti, R. Orito, M. Orlandini, E. Orlando, J.P. Osborne, M. Ostrowski, N. Otte, E. Ovcharov, E. Owen, I. Oya, A. Ozieblo, M. Padovani, A. Pagliaro, A. Paizis, M. Palatiello, M. Palatka, E. Palazzi, J.‑L. Panazol, D. Paneque, S. Panny, Francesca Romana Pantaleo, M. Panter, M. Paolillo, A. Papitto, A. Paravac, J.M. Paredes, G. Pareschi, N. Parmiggiani, R.D. Parsons, P. Paśko, S. R. Patel, B. Patricelli, L. Pavletic, S. Pavy, A. Peer, M. Pecimotika, M.G. Pellegriti, P. Peñil Del Campo, A. Pepato, S. Perard, C. Perennes, M. Peresano, A. Perez Aguilera, J. Perez Romero, M.A. Perez Torres, M. Persic, P. O. Petrucci, O. Petruk, B. Peyaud, K. Pfrang, E. Pian, P. Piatteli, E. Pietropaolo, R. Pillera, D. Pimentel, F. Pintore, C. Pio Garcia, G. Pirola, F. Piron, S. Pita, M. Pohl, V. Poireau, A. Pollo, M. Polo, C. Pongkitivanichkul, J. Porthault, J. Powell, D. Pozo, R.R. Prado, E. Prandini, J. Prast, K. Pressard, G. Principe, N. Produit, D. Prokhorov, H. Prokoph, H. Przybilski, E. Pueschel, G. Pühlhofer, I. Puljak, M.L. Pumo, M. Punch, F. Queiroz, J. Quinn, A. Quirrenbach, P.J. Rajda, R. Rando, S. Razzaque, S. Recchia, P. Reichherzer, O. Reimer, A. Reisenegger, Q. Remy, M. Renaud, T. Reposeur, B. Reville, J.M. Reymond, J. Reynolds, D. Ribeiro, M. Ribo, G. Richards, J. Rico, F. Rieger, L. Riitano, M. Riquelme, D. Riquelme, S. Rivoire, V. Rizi, E. Roache, M. Roche, J. Rodriguez, G. Rodriguez Fernandez, J.C. Rodriguez Ramirez, J.J. Rodriguez Vazquez, G. Rojas, P. Romano, G. Romeo Lobato, C. Romoli, M. Roncadelli, J. Rosado, A. Rosales de Leon, G. Rowell, A. Rugliancich, J.E. Ruiz del Mazo, C. Rulten, C. Russell, F. Russo Hatlen, S. Safi Harb, L. Saha, V. Sahakian, S. Sailer, T. Saito, N. Sakaki, S. Sakurai, G. Salina, H. Salzmann, D. Sanchez, H. Sandaker, A. Sandoval, P. Sangiorgi, M. Sanguillon, H. Sano, M. Santander, A. Santangelo, R. Santos Lima, A. Sanuy, L. Sapozhnikov, T. Saric, S. Sarkar, H. Sasaki, N. Sasaki, Y. Sato, F.G. Saturni, M. Sawada, J. Schaefer, A. Scherer, J. Scherpenberg, P. Schipani, B. Schleicher, J. Schmoll, M. Schneider, H. Schoorlemmer, P. Schovanek, F. Schussler, B. Schwab, U. Schwanke, J. Schwarz, E. Sciacca, S. Scuderi, M. Seglar Arroyo, I. Seitenzahl, D. Semikoz, O. Sergijenko, J.E. Serna Franco, Karol Seweryn, V. Sguera, A. Shalchi, R.Y. Shang, P. Sharma, L. Sidoli, J. Sieiro, H. Siejkowski, A. Sillanpaa, B.B. Singh, K.K. Singh, A. Sinha, C. Siqueira, J. Sitarek, P. Sizun, V. Sliusar, D. Sobczynska, R.W. Sobrinho, H. Sol, G. Sottile, H. Spackman, S. Spencer, G. Spengler, D. Spiga, W. Springer, A. Stamerra, S. Stanic, R. Starling, Ł. Stawarz, Stanislav Stefanik, C. Stegmann, A. Steiner, S. Steinmassl, C. Stella, R. Sternberger, M. Sterzel, C. Stevens, B. Stevenson, T. Stolarczyk, G. Stratta, U. Straumann, J. Striskovic, M. Strzys, R. Stuik, M. Suchenek, Y. Sunada, Tiina Suomijarvi, T. Suric, H. Suzuki, P. Swierk, T. Szepieniec, K. Tachihara, G. Tagliaferri, H. Tajima, N. Tajima, D. Tak, H. Takahashi, M. Takahashi, J. Takata, R. Takeishi, T. Tam, M. Tanaka, T. Tanaka, S. Tanaka, M. Tavani, F. Tavecchio, T. Tavernier, A. Russ Taylor, L.A. Tejedor, P. Temnikov, K. Terauchi, J.C. Terrazas, R. Terrier, T. Terzic, M. Teshima, D. Thibaut, F. Thocquenne, W. Tian, L. Tibaldo, A. Tiengo, M. Tluczykont, C.J. Todero Peixoto, K. Toma, L. Tomankova, J. Tomastik, M. Tornikoski, D.F. Torres, E. Torresi, G. Tosti, L. Tosti, N. Tothill, F. Toussenel, G. Tovmassian, C. Trichard, M. Trifoglio, A. Trois, S. Truzzi, A. Tsiahina, B. Turk, A. Tutone, Y. Uchiyama, P. Utayarat, L. Vaclavek, M. Vacula, V. Vagelli, F. Vagnetti, J.A. Valdivia, M. Valentino, A. Valio, B. Vallage, P. Vallania Quispe, A.M. van den Berg, W. van Driel, C. van Eldik, C. van Rensburg, Brian van Soelen, J. Vandenbroucke, G. Vasileiadis, V. Vassiliev, M. Vazquez Acosta, M. Vecchi, A. Vega, J. Veh, P. Veitch, C. Venter, S. Ventura, S. Vercellone, V. Verguilov, G. Verna, S. Vernetto, V. Verzi, G.P. Vettolani, C. Veyssiere, I. Viale, A. Viana, N. Viaux, J. Vignatti, C.F. Vigorito, J. Villanueva, V. Vitale, V. Vittorini, V. Vodeb, N. Vogel, V. Voisin, S. Vorobiov, M. Vrastil, T. Vuillaume, S.J. Wagner, P. Wagner, K. Wakazono, S.P. Wakely, M. Ward, D. Warren, J. Watson, M. Wechakama, P. Wegner, A. Weinstein, C. Weniger, F. Werner, H. Wetteskind, M. L. White, A. Wierzcholska, S. Wiesand, R. Wijers, M. Wilkinson, M. Will, J. Williams, T. J. Williamson, A. Wolter, Y.W. Wong, M. Wood, T. Yamamoto, H. Yamamoto, Y. Yamane, R. Yamazaki, S. Yanagita, L. Yang, S. Yoo, T. Yoshida, T. Yoshikoshi, P. Yu, A. Yusafzai, Michael Zacharias, B. Zaldivar, L. Zampieri, R. Zanin, R. Zanmar Sanchez, D. Zaric, M. Zavrtanik, D. Zavrtanik, Andrzej Zdziarski, A. Zech, H. Zechlin, A. Zenin, A. Zerwekh, K. Ziętara, A. Zink, J. Ziolkowski, M. Zivec, A. Zmija, Współautorami artykułu są członkowie CTA Observatory, CTA Consortium i LST Collaboration w liczbie 1139, Astronomy, Research unit Nuclear & Hadron Physics, and Research unit Astroparticle Physics
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Physics ,Observatory ,Gamma ray ,Astronomy - Abstract
Very-high Energy (VHE) gamma-ray astroparticle physics is a relatively young field, and observations over the past decade have surprisingly revealed almost two hundred VHE emitters which appear to act as cosmic particle accelerators. These sources are an important component of the Universe, influencing the evolution of stars and galaxies. At the same time, they also act as a probe of physics in the most extreme environments known - such as in supernova explosions, and around or after the merging of black holes and neutron stars. However, the existing experiments have provided exciting glimpses, but often falling short of supplying the full answer. A deeper understanding of the TeV sky requires a significant improvement in sensitivity at TeV energies, a wider energy coverage from tens of GeV to hundreds of TeV and a much better angular and energy resolution with respect to the currently running facilities. The next generation gamma-ray observatory, the Cherenkov Telescope Array Observatory (CTAO), is the answer to this need. In this talk I will present this upcoming observatory from its design to the construction, and its potential science exploitation. CTAO will allow the entire astronomical community to explore a new discovery space that will likely lead to paradigm-changing breakthroughs. In particular, CTA has an unprecedented sensitivity to short (sub-minute) timescale phenomena, placing it as a key instrument in the future of multi-messenger and multi-wavelength time domain astronomy. I will conclude the talk presenting the first scientific results obtained by the LST-1, the prototype of one CTAO telescope type - the Large-Sized Telescope, that is currently under commission., PoS: Proceedings of Science, 395, ISSN:1824-8039, Proceedings of 37th International Cosmic Ray Conference (ICRC2021)
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- 2022
42. Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline
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Raghu, G. Remy-Jardin, M. Richeldi, L. Thomson, C.C. Antoniou, K.M. Bissell, B.D. Bouros, D. Buendia-Roldan, I. Caro, F. Crestani, B. Ewing, T. Ghazipura, M. Herman, D.D. Ho, L. Hon, S.M. Hossain, T. Inoue, Y. Johkoh, T. Jones, S. Kheir, F. Khor, Y.H. Knight, S.L. Kreuter, M. Lynch, D.A. Macrea, M. Maher, T.M. Mammen, M.J. Martinez, F.J. Molina-Molina, M. Morisset, J. Myers, J.L. Nicholson, A.G. Olson, A.L. Podolanczuk, A. Poletti, V. Ryerson, C.J. Selman, M. Strek, M.E. Troy, L.K. Wijsenbeek, M. Wilson, K.C. the American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, Asociacion Latinoamericana de Torax
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respiratory system ,respiratory tract diseases - Abstract
Background: This American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Asociacion Latinoamericana de Torax guideline updates prior idiopathic pulmonary fibrosis (IPF) guidelines and addresses the progression of pulmonary fibrosis in patients with interstitial lung diseases (ILDs) other than IPF. Methods: A committee was composed of multidisciplinary experts in ILD, methodologists, and patient representatives. 1) Update of IPF: Radiological and histopathological criteria for IPF were updated by consensus. Questions about transbronchial lung cryobiopsy, genomic classifier testing, antacid medication, and antireflux surgery were informed by systematic reviews and answered with evidence-based recommendations using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. 2) Progressive pulmonary fibrosis (PPF): PPF was defined, and then radiological and physiological criteria for PPF were determined by consensus. Questions about pirfenidone and nintedanib were informed by systematic reviews and answered with evidence-based recommendations using the GRADE approach. Results: 1) Update of IPF: A conditional recommendation was made to regard transbronchial lung cryobiopsy as an acceptable alternative to surgical lung biopsy in centers with appropriate expertise. No recommendation was made for or against genomic classifier testing. Conditional recommendations were made against antacid medication and antireflux surgery for the treatment of IPF. 2) PPF: PPF was defined as at least two of three criteria (worsening symptoms, radiological progression, and physiological progression) occurring within the past year with no alternative explanation in a patient with an ILD other than IPF. A conditional recommendation was made for nintedanib, and additional research into pirfenidone was recommended. Conclusions: The conditional recommendations in this guideline are intended to provide the basis for rational, informed decisions by clinicians. © 2022 by the American Thoracic Society
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- 2022
43. Application of genetic algorithms for parameters identification in a developing smart gear system
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T.-T. Mac, D. Iba, Y. Matsushita, S. Mukai, T. Inoue, A. Fukushima, N. Miura, T. Iizuka, A. Masuda, and I. Moriwaki
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- 2022
44. Animated solid model of the lung constructed from unsynchronized MR sequential images.
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Marcos de Sales Guerra Tsuzuki, Fábio Kawaoka Takase, Toshiyuki Gotoh, Seiichiro Kagei, Akira Asakura, Tae Iwasawa, and T. Inoue
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- 2009
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45. Backcalculation of Pavement Layer Moduli without Using D0-Deflection
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J.W. Maina, T. Inoue, A. Kasahara, and K. Matsui
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- 2021
46. Recalibration Methods for Improved Clinical Utility of Risk Scores
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Robyn L. McClelland, Lurdes Y. T. Inoue, Anu Mishra, and Kathleen F. Kerr
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Framingham Risk Score ,Computer science ,Calibration (statistics) ,Health Policy ,Constrained optimization ,Cardiology ,Interval (mathematics) ,American Heart Association ,Atherosclerosis ,Risk Assessment ,Mesa ,United States ,R package ,Risk analysis (engineering) ,Risk Factors ,Cohort ,Humans ,Risk threshold ,computer ,computer.programming_language - Abstract
Background An established risk model may demonstrate miscalibration, meaning predicted risks do not accurately capture event rates. In some instances, investigators can identify and address the cause of miscalibration. In other circumstances, it may be appropriate to recalibrate the risk model. Existing recalibration methods do not account for settings in which the risk score will be used for risk-based clinical decision making. Methods We propose 2 new methods for risk model recalibration when the intended purpose of the risk model is to prescribe an intervention to high-risk individuals. Our measure of risk model clinical utility is standardized net benefit. The first method is a weighted strategy that prioritizes good calibration at or around the critical risk threshold. The second method uses constrained optimization to produce a recalibrated risk model with maximum possible net benefit, thereby prioritizing good calibration around the critical risk threshold. We also propose a graphical tool for assessing the potential for recalibration to improve the net benefit of a risk model. We illustrate these methods by recalibrating the American College of Cardiology (ACC)–American Heart Association (AHA) atherosclerotic cardiovascular disease (ASCVD) risk score within the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. Results New methods are implemented in the R package ClinicalUtilityRecal. Recalibrating the ACC-AHA-ASCVD risk score for a MESA subcohort results in higher estimated net benefit using the proposed methods compared with existing methods, with improved calibration in the most clinically impactful regions of risk. Conclusion The proposed methods target good calibration for critical risks and can improve the net benefit of a risk model. We recommend constrained optimization when the risk model net benefit is paramount. The weighted approach can be considered when good calibration over an interval of risks is important.
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- 2021
47. Analysis of hydrochemical parameters and dissolved zinc interaction by using PHREEQC simulation
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H Alimuddin, P Andarani, K Yokota, T Inoue, and M N Nguyen
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General Medicine ,General Chemistry - Abstract
Zinc is frequently reacting with inorganic species in water to form zinc species. Thus, the chemical speciation of Zinc in the aquatic environment has become a significant concern nowadays due to its adverse effect on humans and its potential toxicity in the water system. In this study, to investigate the interaction between dissolved zinc and hydro-chemical factors and to estimate the Zn speciation form, samples of river water were collected spatially from the Umeda River mainstream and tributaries in different seasons for one year. The hydrochemistry and dissolved zinc pollution characteristics of the samples were analyzed. Zn speciation was assessed by PHREEQC simulation. The result show that the main form of Zn speciation was Zinc free ion (Zn2+) in all seasons. However, in summer and spring season, the ZnCO3 and ZnOH+ concentration was higher than the other season. These speciation form may be attributed to the activities around the river in different season according to the similarities in downstream and upstream areas by the hierarchical cluster analysis result.
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- 2022
48. Decreased Diversity of Gut Microbiota Is Associated with Decreased Muscle Mass and Function in Older Adults Residing in a Nursing Home
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Y. Ishida, Keisuke Maeda, T. Inoue, S. Satake, and N. Mori
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Feces ,Nutrition and Dietetics ,Muscles ,RNA, Ribosomal, 16S ,Humans ,Medicine (miscellaneous) ,Geriatrics and Gerontology ,Aged ,Gastrointestinal Microbiome ,Nursing Homes - Published
- 2022
49. GroEL on hydrophilized graphene grid (high particle density)
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J, Fujita, additional, F, Makino, additional, H, Asahara, additional, M, Moriguchi, additional, S, Kumano, additional, I, Anzai, additional, J, Kishikawa, additional, Y, Matsuura, additional, T, Kato, additional, K, Namba, additional, and T, Inoue, additional
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- 2021
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50. SARS-CoV-2 spike protein (1-up RBD) on EG-grid
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J, Fujita, additional, F, Makino, additional, H, Asahara, additional, M, Moriguchi, additional, S, Kumano, additional, I, Anzai, additional, J, Kishikawa, additional, Y, Matsuura, additional, T, Kato, additional, K, Namba, additional, and T, Inoue, additional
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- 2021
- Full Text
- View/download PDF
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