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21 results on '"Tőke, Enikő R."'

1. Supplementary Figure from Safety and Activity of PolyPEPI1018 Combined with Maintenance Therapy in Metastatic Colorectal Cancer: an Open-Label, Multicenter, Phase Ib Study

Author

Hubbard, Joleen M., primary, Tőke, Enikő R., primary, Moretto, Roberto, primary, Graham, Rondell P., primary, Youssoufian, Hagop, primary, Lőrincz, Orsolya, primary, Molnár, Levente, primary, Csiszovszki, Zsolt, primary, Mitchell, Jessica L., primary, Wessling, Jaclynn, primary, Tóth, József, primary, and Cremolini, Chiara, primary

Published
2023
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2. Supplementary Table from Safety and Activity of PolyPEPI1018 Combined with Maintenance Therapy in Metastatic Colorectal Cancer: an Open-Label, Multicenter, Phase Ib Study

Author

Hubbard, Joleen M., primary, Tőke, Enikő R., primary, Moretto, Roberto, primary, Graham, Rondell P., primary, Youssoufian, Hagop, primary, Lőrincz, Orsolya, primary, Molnár, Levente, primary, Csiszovszki, Zsolt, primary, Mitchell, Jessica L., primary, Wessling, Jaclynn, primary, Tóth, József, primary, and Cremolini, Chiara, primary

Published
2023
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3. T cell immunity ameliorates COVID-19 disease severity and provides post-exposure prophylaxis after peptide-vaccination, in Syrian hamsters

Author

Somogyi, Eszter, primary, Kremlitzka, Mariann, additional, Csiszovszki, Zsolt, additional, Molnár, Levente, additional, Lőrincz, Orsolya, additional, Tóth, József, additional, de Waal, Leon, additional, Pattijn, Sofie, additional, Reineking, Wencke, additional, Beineke, Andreas, additional, and Tőke, Enikő R., additional

Published
2023
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7. Safety and Activity of PolyPEPI1018 Combined with Maintenance Therapy in Metastatic Colorectal Cancer: an Open-Label, Multicenter, Phase Ib Study

Author

Hubbard, Joleen M., primary, Tőke, Enikő R., additional, Moretto, Roberto, additional, Graham, Rondell P., additional, Youssoufian, Hagop, additional, Lőrincz, Orsolya, additional, Molnár, Levente, additional, Csiszovszki, Zsolt, additional, Mitchell, Jessica L., additional, Wessling, Jaclynn, additional, Tóth, József, additional, and Cremolini, Chiara, additional

Published
2022
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8. T cell immunity ameliorates COVID-19 disease severity and provides post-exposure prophylaxis after peptidevaccination, in Syrian hamsters.

Author

Somogyi, Eszter, Kremlitzka, Mariann, Csiszovszki, Zsolt, Molnár, Levente, Lőrincz, Orsolya, Tóth, József, Waal, Leon de, Pattijn, Sofie, Reineking, Wencke, Beineke, Andreas, and Tőke, Enikő R.

Abstract

Background: The emergence of novel SARS-CoV-2 variants that resist neutralizing antibodies drew the attention to cellular immunity and calls for the development of alternative vaccination strategies to combat the pandemic. Here, we have assessed the kinetics of T cell responses and protective efficacy against severe COVID-19 in pre- and post-exposure settings, elicited by PolyPEPI-SCoV-2, a peptide based T cell vaccine. Methods: 75 Syrian hamsters were immunized subcutaneously with PolyPEPI-SCoV-2 on D0 and D14. On D42, hamsters were intranasally challenged with 102 TCID50 of the virus. To analyze immunogenicity by IFN-γ ELISPOT and antibody secretion, lymphoid tissues were collected both before (D0, D14, D28, D42) and after challenge (D44, D46, D49). To measure vaccine efficacy, lung tissue, throat swabs and nasal turbinate samples were assessed for viral load and histopathological changes. Further, body weight was monitored on D0, D28, D42 and every day after challenge. Results: The vaccine induced robust activation of T cells against all SARS-CoV-2 structural proteins that were rapidly boosted after virus challenge compared to control animals (~4-fold, p<0.05). A single dose of PolyPEPI-SCoV-2 administered one day after challenge also resulted in elevated T cell response (p<0.01). The vaccination did not induce virus-specific antibodies and viral load reduction. Still, peptide vaccination significantly reduced body weight loss (p<0.001), relative lung weight (p<0.05) and lung lesions (p<0.05), in both settings. Conclusion: Our study provides first proof of concept data on the contribution of T cell immunity on disease course and provide rationale for the use of T cell-based peptide vaccines against both novel SARS-CoV-2 variants and supports post-exposure prophylaxis as alternative vaccination strategy against COVID-19. [ABSTRACT FROM AUTHOR]

Published
2023
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11. A Peptide Vaccine Candidate Tailored to Individuals' Genetics Mimics the Multi-Targeted T Cell Immunity of COVID-19 Convalescent Subjects

Author

Somogyi, Eszter, primary, Csiszovszki, Zsolt, additional, Molnár, Levente, additional, Lőrincz, Orsolya, additional, Tóth, József, additional, Pattijn, Sofie, additional, Schockaert, Jana, additional, Mazy, Aurélie, additional, Miklós, István, additional, Pántya, Katalin, additional, Páles, Péter, additional, and Tőke, Enikő R., additional

Published
2021
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16. Peptide vaccine candidate mimics the heterogeneity of natural SARS-CoV-2 immunity in convalescent humans and induces broad T cell responses in mice models

Author

Somogyi, Eszter, primary, Csiszovszki, Zsolt, additional, Molnár, Levente, additional, Lőrincz, Orsolya, additional, Tóth, József, additional, Pattijn, Sofie, additional, Schockaert, Jana, additional, Mazy, Aurélie, additional, Miklós, István, additional, Pántya, Katalin, additional, Páles, Péter, additional, and Tőke, Enikő R., additional

Published
2020
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19. Single DermaVir Immunization: Dose-Dependent Expansion of Precursor/Memory T Cells against All HIV Antigens in HIV-1 Infected Individuals

Author

Lisziewicz, Julianna, primary, Bakare, Nyasha, additional, Calarota, Sandra A., additional, Bánhegyi, Dénes, additional, Szlávik, János, additional, Újhelyi, Eszter, additional, Tőke, Enikő R., additional, Molnár, Levente, additional, Lisziewicz, Zsolt, additional, Autran, Brigitte, additional, and Lori, Franco, additional

Published
2012
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