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9. Verkürzung der Erythrocytenlebensdauer: Hämolytische Anämien : Hereditäre, corpusculäre, hämolytische Anämien

Author

Tönz, O., Damerow, R., Betke, K., Gasser, C., Opitz, H., editor, Schmid, F., editor, Weicker, H., editor, Althoff, H., editor, Baumgartner, G., editor, Beckmann, R., editor, Betke, K., editor, Bettex, M., editor, Burgio, G. R., editor, Cottier, H., editor, Damerow, R., editor, Degenhardt, K.-H., editor, Diemer, K., editor, Emrich, R., editor, Fey, F., editor, Fichsel, H., editor, Flatz, G., editor, Garby, L., editor, Gasser, C., editor, Gugler, E., editor, Hansen, H. G., editor, Hauke, H., editor, Haupt, H., editor, Hitzig, W. H., editor, Hövels, O., editor, Jacobi, H., editor, Jéquier, S., editor, Jonxis, J. H. P., editor, Kaufmann, H. J., editor, Kleihauer, E. F., editor, Künzer, W., editor, Kuhnke, E., editor, Laissue, J., editor, Leiber, B., editor, Lüscher, E. F., editor, Maier, W. A., editor, Marti, H. R., editor, Merker, H., editor, Murken, J.-D., editor, Oehme, J., editor, Ofteringer, K., editor, Plenert, W., editor, Rind, H. J., editor, Rogner, G., editor, Roos, B., editor, Ruhrmann, G., editor, Schönenberg, H., editor, Schröder, G., editor, Spranger, J., editor, Stobbe, H., editor, Theiler, K., editor, Thomas, G., editor, Tönz, O., editor, Versé, H., editor, Vest, M., editor, Weippl, G., editor, Weyers, H., editor, Wiedemann, H.-R., editor, and Wilhelm, G., editor

Published
1967
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10. Röteln (Rubeolen)

Author

Tönz, O., Rossi, E., Gsell, O., editor, Mohr, W., editor, Blaškovič, D., editor, Bock, H. E., editor, Fanconi, G., editor, Friolet, B., editor, Germer, W. D., editor, Gibbels, E., editor, Henneberg, G., editor, Knüttgen, H., editor, Libíková, H., editor, Malamos, B., editor, Mayer, J. B., editor, Oehme, J., editor, Rossi, E., editor, Scheid, W., editor, Seifert, G., editor, Siegert, R., editor, Stüttgen, G., editor, Tönz, O., editor, Weisse, K., editor, Gugler, E., editor, von Harnack, G.-A., editor, Lippelt, H., editor, Löffler, H., editor, Lüthy, F., editor, Paccaud, M. F., editor, von Rechenberg, H. K., editor, Regamey, R. H., editor, Reimann, H. A., editor, Rieger, H., editor, Said, M. E., editor, Siede, W., editor, and Sonck, C. E., editor

Published
1967
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14. Folsäure – Freiwilliger Zusatz bei diversen Lebensmitteln oder obligate Anreicherung eines Grundnahrungsmittels?

Author

Tönz O

Subjects
Gynecology, medicine.medical_specialty, Mandatory fortification, business.industry, medicine, Staple food, General Medicine, business, Folic acid supplementation
Abstract

Eine normale, landesübliche Mischkost reicht nicht aus, um den von wissenschaftlichen Gremien definierten Tagesbedarf von 400 μg Folsäure zu decken. Das Angebot diverser Folsäure-angereicherter Lebensmittel scheint deshalb berechtigt. Ob damit eine prophylaktische Wirkung auf die verschiedenen Homocystein-assoziierten Krankheiten der zweiten Lebenshälfte erwartet werden kann, ist allerdings nicht bewiesen, sondern nur fundierte Hypothese. Für die Verhütung von Neuralrohrdefekten und andern embryonalen Missbildungen und frühkindlichen Malignomen ist eine medikamentöse Prophylaxe mit 0,4–0,8 mg Folsäure notwendig, oder die generelle, d.h. obligate Anreicherung von Backmehl. Die Problematik dieser im Ausland erfolgreich erprobten Maßnahme wird diskutiert.

Published
2007

15. Stirbt die Schweiz aus?

Author

Tönz O

Subjects
Political science, Child bearing, Obstetrics and Gynecology, General Medicine, Humanities
Abstract

Seit Jahrzehnten unterschreiten in den meisten Ländern Europas die Geburtenziffern den für eine Konstanterhaltung der Bevölkerung notwenigen Sollwert beträchtlich. In der Schweiz beträgt die Gesamtfertilität 1,37 Kinder pro Frau zwischen 15 und 48 Jahren (Soll 2,1); die Schweizerinnen allein – ohne Ausländer – haben den historischen Tiefstwert von 1,21 erreicht. Bei der einheimischen Bevölkerung besteht seit 1998 ein negativer Geburtenüberschuss, d.h. die Aufrechterhaltung der Einwohnerzahl wird nur noch durch Immigration gewährleistet. Bei Weiterbestehen dieser niedrigen Geburtenziffern würde die einheimische Bevölkerung ohne weitere Zuwanderung schon innerhalb von 200 Jahren auf 2% der heutigen Grösse zusammenschrumpfen, also praktisch aussterben. Ursachen dieser demografisch bedenklichen Entwicklung und allenfalls mögliche Gegenmassnahmen werden kurz skizziert.

Published
2005

16. Anomale Hämoglobine : Klinische Aspekte

Author

Tönz, O., Bachmann, K. D., editor, Berger, H., editor, Bierich, J., editor, Boda, D., editor, Bremer, H.-J., editor, Brodehl, J., editor, Burgio, G. R., editor, Fischer, K., editor, Gladtke, E., editor, Hadorn, B., editor, Hagberg, B., editor, Hallman, N., editor, Hansen, H. G., editor, Harbauer, H., editor, von Harnack, G.-A., editor, Hecker, W. C., editor, Helge, H., editor, Hitzig, W. H., editor, Huth, E., editor, Kleihauer, E., editor, Künzer, W., editor, Lassrich, M. A., editor, Leiber, B., editor, Lindquist, B., editor, Marget, W., editor, Oehme, J., editor, Olbing, H., editor, Pfeiffer, R. A., editor, Prader, A., editor, Riegel, K., editor, Rossi, E., editor, Schärer, K., editor, Schmidt, E., editor, Schulte, F.-J., editor, Spiess, H., editor, Spranger, J., editor, Stalder, G., editor, Stephan, U., editor, Stoermer, J., editor, Ströder, J., editor, Teller, W., editor, Zetterström, R., editor, and Zweymüller, E., editor

Published
1980
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23. Die Zecken-Meningoradikulitis - eine Spirochätose

Author

Caflisch, U., Tönz, O., Schaad, U. B., Aeschlimann, André, and Burgdorfer, Willy

Abstract

Es wird über drei Fälle von Zekken-Meningoradikulitis im Kindesalter berichtet. Diese Erkrankung ist klinisch durch eine typische Symptomenfolge gekennzeichnet: Erythema chronicum migrans, lokalisierte Schmerzen und schliesslich asymmetrische neurologische Ausfälle (insbesondere Fazialisparesen), begleitet von chronischer lymphozytärer Meningitis. Aufgrund serologischer Untersuchungen an unseren Patienten darf angenommen werden, dass es sich bei dieser Krankheit wie bei der amerikanischen Lyme-Arthritis um eine Spirochätose handelt. Analoge positive Serumtiter konnten wir bei weiteren Patienten mit Erythema chronicum migrans und bei einem Kind mit benigner Lymphadenosis cutis Bäfverstedt nachweisen (s. Anhang). 20% der in der Region Luzern untersuchten Zecken (Ixodes ricinus) sind tatsächlich Träger dieser kürzlich entdeckten Zecken-Spirochäte. Three pediatric cases oftick-bomemeningoradiculitis are presented. This disease is characterized by a distinct sequence of symptoms: erythema chronicum migrans, localized pain. and eventually radicular asymmetric neurologic involvement (in particular facial palsy) associated with findings of aseptic meningitis. On the basis of specific serologic data in these three patients, it is suggested that the etiology of tick-borne meningoradiculitis is also spirochetal, as recently shown for the tick-associated Lyme disease. Analogue positive spirochetal antibody liters were found in additional patients with erythema chronicum migrans and in a child with Bafverstedt cutaneous ymphadenosis (see addendum). 20% of tick specimens collected in the area of Lucerne (Ixodes ricinus) were infected by these spirochetes.

Published
2011

27. Störung der Normoblastenentkernung: Pseudoaplastische Anämie

Author

Weicker, H., primary, Althoff, H., additional, Baumgartner, G., additional, Beckmann, R., additional, Betke, K., additional, Bettex, M., additional, Burgio, G. R., additional, Cottier, H., additional, Damerow, R., additional, Degenhardt, K.-H., additional, Diemer, K., additional, Emrich, R., additional, Fey, F., additional, Fichsel, H., additional, Flatz, G., additional, Garby, L., additional, Gasser, C., additional, Gugler, E., additional, Hansen, H. G., additional, Hauke, H., additional, Haupt, H., additional, Hitzig, W. H., additional, Hövels, O., additional, Jacobi, H., additional, Jéquier, S., additional, Jonxis, J. H. P., additional, Kaufmann, H. J., additional, Kleihauer, E. F., additional, Künzer, W., additional, Kuhnke, E., additional, Laissue, J., additional, Leiber, B., additional, Lüscher, E. F., additional, Maier, W. A., additional, Marti, H. R., additional, Merker, H., additional, Murken, J.-D., additional, Oehme, J., additional, Ofteringer, K., additional, Plenert, W., additional, Rind, H. J., additional, Rogner, G., additional, Roos, B., additional, Ruhrmann, G., additional, Schmid, F., additional, Schönenberg, H., additional, Schröder, G., additional, Spranger, J., additional, Stobbe, H., additional, Theiler, K., additional, Thomas, G., additional, Tönz, O., additional, Versé, H., additional, Vest, M., additional, Weippl, G., additional, Weyers, H., additional, Wiedemann, H.-R., additional, and Wilhelm, G., additional

Published
1967
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30. Congenital sensory neuropathy with anhidrosis.

Author

VASSELLA, F., EMRICH, H. M., KRAUS-RUPPERT, R., AUFDERMAUR, F., TÖNZ, O., and Tönz, O

Subjects
CHLORIDES analysis, ACETYLCHOLINE, ADRENALINE, CONSANGUINITY, PEOPLE with intellectual disabilities, MOTOR ability, PERIPHERAL neuropathy, NEUROLOGIC examination, PAIN, PERSPIRATION, SELF-mutilation, SWEAT glands, DISEASE complications
Published
1968
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37. Vitamin K1Concentration in Breast-Fed Neonates After Oral or Intramuscular Administration of a Single Dose of a New Mixed-Micellar Preparation of Phylloquinone

Author

Schubiger, G., Tönz, O., Grüter, J., and Shearer, M. J.

Abstract

The plasma disposition of a new mixedmicellar preparation (KONAKION MM, Roche) of phylloquinone (vitamin K1) has been studied in 25 healthy, fully breast-fed, newborn babies, randomized to receive a single dose of either 1.5 mg i.m. (11 babies) or 3 mg p.o. (14 babies). Venous blood samples were collected at 25 h, 4 days, and 24 days. After p.o. administration, the median plasma phylloquinone concentration increased to 89 ng/ml after 24 h, then decreased to 51 ng/ml after 4 days; the respective concentrations after i.m. injection were 146 ng/ml and 34 ng/ml. The higher plasma phylloquinone level in the i.m. group after 24 h was not statistically significant compared with that of the p.o. group, but the reversed higher concentration in the p.o. group after 4 days was significant (p < 0.01). After 24 days the median plasma phylloquinone had decreased to 0.44 ng/ml (range 0.19–1.44) and 1.05 ng/ml (range 0.37–1.87) in the p.o. and i.m. groups, respectively. There was a significant difference between these plasma concentrations (p < 0.01). They were within or above the reference adult fasting range (0.17–0.68 ng/ml). The narrow range of plasma concentrations at 24 h and 4 days suggests a greater consistency of absorption from this micellar preparation than from other emulsion-based preparations. Further studies are required to assess the long-term protection of a single oral dose against late hemorrhagic disease of the newborn. Until such time, breast-fed babies given this preparation orally should receive (an) additional dose(s).

Published
1993
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38. Vitamin K1Concentration in BreastFed Neonates After Oral or Intramuscular Administration of a Single Dose of a New MixedMicellar Preparation of Phylloquinone

Author

Schubiger, G., Tönz, O., Grüter, J., and Shearer, M. J.

Abstract

The plasma disposition of a new mixedmicellar preparation (KONAKION MM, Roche) of phylloquinone (vitamin K1) has been studied in 25 healthy, fully breast-fed, newborn babies, randomized to receive a single dose of either 1.5 mg i.m. (11 babies) or 3 mg p.o. (14 babies). Venous blood samples were collected at 25 h, 4 days, and 24 days. After p.o. administration, the median plasma phylloquinone concentration increased to 89 ng/ml after 24 h, then decreased to 51 ng/ml after 4 days; the respective concentrations after i.m. injection were 146 ng/ml and 34 ng/ml. The higher plasma phylloquinone level in the i.m. group after 24 h was not statistically significant compared with that of the p.o. group, but the reversed higher concentration in the p.o. group after 4 days was significant (p < 0.01). After 24 days the median plasma phylloquinone had decreased to 0.44 ng/ml (range 0.19–1.44) and 1.05 ng/ml (range 0.37–1.87) in the p.o. and i.m. groups, respectively. There was a significant difference between these plasma concentrations (p < 0.01). They were within or above the reference adult fasting range (0.17–0.68 ng/ml). The narrow range of plasma concentrations at 24 h and 4 days suggests a greater consistency of absorption from this micellar preparation than from other emulsion-based preparations. Further studies are required to assess the long-term protection of a single oral dose against late hemorrhagic disease of the newborn. Until such time, breast-fed babies given this preparation orally should receive (an) additional dose(s).

Published
1993

39. Imaging diagnosis and follow-up of infantile hepatic haemangioendothelioma: a case report.

Author

Berger, Thomas, Berger, Markus, Hoffman, Alan, Zimmerman, Donald, Tönz, Otmar, Berger, T M, Berger, M F, Hoffman, A D, Zimmerman, D, and Tönz, O

Abstract

A 4-week-old male infant was admitted to the hospital with acute gastrointestinal bleeding and marked coagulopathy secondary to vitamin K malabsorption in the presence of cholestasis. Physical examination revealed hepatomegaly and cutaneous haemangiomas. Ultrasonography, CT, and MRI demonstrated a multifocal vascular process and allowed the diagnosis of infantile hepatic haemangioendothelioma to be made without the use of more invasive diagnostic procedures. To avoid high-output congestive heart failure, the patient was treated with oral corticosteroids. After 5 months, rapid involution of the vascular malformations ensued. At age 2 years, a magnetic resonance scan confirmed complete resolution of the hepatic haemangioendothelioma. [ABSTRACT FROM AUTHOR]

Published
1994
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40. Familial epilepsy and yellow teeth--a disease of the CNS associated with enamel hypoplasia

Author

Alfried Kohlschütter, Chappuis D, Meier C, Tönz O, Vassella F, and Herschkowitz N

Subjects
Brain Chemistry, Inclusion Bodies, Male, Cytoplasm, Sodium, Brain, Infant, Electroencephalography, Nerve Fibers, Myelinated, Axons, Chlorides, Child, Preschool, Intellectual Disability, Potassium, Humans, Dental Enamel Hypoplasia, Female, Epilepsy, Tonic-Clonic, Child, Pneumoencephalography, Sweat, Neuroglia

41. Die Zecken-Meningoradikulitis - eine Spirochätose

Author

Caflisch, U., Tönz, O., Schaad, U. B., Aeschlimann, André, Burgdorfer, Willy, Caflisch, U., Tönz, O., Schaad, U. B., Aeschlimann, André, and Burgdorfer, Willy

Abstract

Es wird über drei Fälle von Zekken-Meningoradikulitis im Kindesalter berichtet. Diese Erkrankung ist klinisch durch eine typische Symptomenfolge gekennzeichnet: Erythema chronicum migrans, lokalisierte Schmerzen und schliesslich asymmetrische neurologische Ausfälle (insbesondere Fazialisparesen), begleitet von chronischer lymphozytärer Meningitis. Aufgrund serologischer Untersuchungen an unseren Patienten darf angenommen werden, dass es sich bei dieser Krankheit wie bei der amerikanischen Lyme-Arthritis um eine Spirochätose handelt. Analoge positive Serumtiter konnten wir bei weiteren Patienten mit Erythema chronicum migrans und bei einem Kind mit benigner Lymphadenosis cutis Bäfverstedt nachweisen (s. Anhang). 20% der in der Region Luzern untersuchten Zecken (Ixodes ricinus) sind tatsächlich Träger dieser kürzlich entdeckten Zecken-Spirochäte., Three pediatric cases oftick-bomemeningoradiculitis are presented. This disease is characterized by a distinct sequence of symptoms: erythema chronicum migrans, localized pain. and eventually radicular asymmetric neurologic involvement (in particular facial palsy) associated with findings of aseptic meningitis. On the basis of specific serologic data in these three patients, it is suggested that the etiology of tick-borne meningoradiculitis is also spirochetal, as recently shown for the tick-associated Lyme disease. Analogue positive spirochetal antibody liters were found in additional patients with erythema chronicum migrans and in a child with Bafverstedt cutaneous ymphadenosis (see addendum). 20% of tick specimens collected in the area of Lucerne (Ixodes ricinus) were infected by these spirochetes.

49. Koagulopathien

Author

Rogner, G., Opitz, H., editor, Schmid, F., editor, Weicker, H., editor, Althoff, H., editor, Baumgartner, G., editor, Beckmann, R., editor, Betke, K., editor, Bettex, M., editor, Burgio, G. R., editor, Cottier, H., editor, Damerow, R., editor, Degenhardt, K.-H., editor, Diemer, K., editor, Emrich, R., editor, Fey, F., editor, Fichsel, H., editor, Flatz, G., editor, Garby, L., editor, Gasser, C., editor, Gugler, E., editor, Hansen, H. G., editor, Hauke, H., editor, Haupt, H., editor, Hitzig, W. H., editor, Hövels, O., editor, Jacobi, H., editor, Jéquier, S., editor, Jonxis, J. H. P., editor, Kaufmann, H. J., editor, Kleihauer, E. F., editor, Künzer, W., editor, Kuhnke, E., editor, Laissue, J., editor, Leiber, B., editor, Lüscher, E. F., editor, Maier, W. A., editor, Marti, H. R., editor, Merker, H., editor, Murken, J.-D., editor, Oehme, J., editor, Ofteringer, K., editor, Plenert, W., editor, Rind, H. J., editor, Rogner, G., editor, Roos, B., editor, Ruhrmann, G., editor, Schönenberg, H., editor, Schröder, G., editor, Spranger, J., editor, Stobbe, H., editor, Theiler, K., editor, Thomas, G., editor, Tönz, O., editor, Versé, H., editor, Vest, M., editor, Weippl, G., editor, Weyers, H., editor, Wiedemann, H.-R., editor, and Wilhelm, G., editor

Published
1967
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50. Die Differenzierungsstörungen der Erythropoese: die aplastischen und die hypoplastischen Anämien

Author

Fichsel, H., Opitz, H., editor, Schmid, F., editor, Weicker, H., editor, Althoff, H., editor, Baumgartner, G., editor, Beckmann, R., editor, Betke, K., editor, Bettex, M., editor, Burgio, G. R., editor, Cottier, H., editor, Damerow, R., editor, Degenhardt, K.-H., editor, Diemer, K., editor, Emrich, R., editor, Fey, F., editor, Fichsel, H., editor, Flatz, G., editor, Garby, L., editor, Gasser, C., editor, Gugler, E., editor, Hansen, H. G., editor, Hauke, H., editor, Haupt, H., editor, Hitzig, W. H., editor, Hövels, O., editor, Jacobi, H., editor, Jéquier, S., editor, Jonxis, J. H. P., editor, Kaufmann, H. J., editor, Kleihauer, E. F., editor, Künzer, W., editor, Kuhnke, E., editor, Laissue, J., editor, Leiber, B., editor, Lüscher, E. F., editor, Maier, W. A., editor, Marti, H. R., editor, Merker, H., editor, Murken, J.-D., editor, Oehme, J., editor, Ofteringer, K., editor, Plenert, W., editor, Rind, H. J., editor, Rogner, G., editor, Roos, B., editor, Ruhrmann, G., editor, Schönenberg, H., editor, Schröder, G., editor, Spranger, J., editor, Stobbe, H., editor, Theiler, K., editor, Thomas, G., editor, Tönz, O., editor, Versé, H., editor, Vest, M., editor, Weippl, G., editor, Weyers, H., editor, Wiedemann, H.-R., editor, and Wilhelm, G., editor

Published
1967
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