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Background Biologics are commonly used for the treatment of Crohn’s disase (CD); however, the proportion of biologics used and their initiation time from diagnosis differs widely between different regions. There is limited information about the patient characteristics and the treatment persistence of each initial biologics, and the treatment persistence of top-down and step-up therapy. iCREST-CD is a prospective, non-interventional, longitudinal, observational registry study conducted at 19 tertiary centres to understand the characteristics of CD treatments in actual clinical settings in Japan. We conducted an interim analysis (cutoff date: 30 June 2022) of iCREST-CD to mainly evaluate the indication and outcomes of initial biologic therapy. Methods Patients newly diagnosed with CD after June 2016 based on the diagnostic criteria of the Japanese Guidelines, aged ≥16 years at the time of informed consent with no prior exposure to biologics were enrolled. Patient demographics, clinical data, disease activity and medical treatment were recorded. Biologic use without prior steroid use was defined as top-down and biologic use with prior steroid use was defined as step-up. Results A total of 672 eligible patients (68.2% male) with mean age (±SD) of 29.4 (13.1) years were analysed. Cumulative proportion of patients prescribed 5-aminosalicylic acid, steroids, immunomodulators, and biologics at 6- and 12-months from diagnosis were 71.3%, 40.6%, 31.4%, and 47.5%; and 75.0%, 43.6%, 36.0%, and 59.7%, respectively (Figure 1). A total of 498 patients received biological therapy—infliximab (IFX; 121 [24.3%]), adalimumab (ADA; 244 [49.0%]), ustekinumab (UST; 107 [21.5%]), and vedolizumab (VDZ; 26 [5.2%]). The mean age (±SD) at the initiation of biologic treatment was IFX: 28.2 (11.3), ADA: 26.6 (10.8), UST: 30.4 (14.1), and VDZ: 36.2 (17.4), and the mean (±SD) levels of C-reactive protein (CRP) (mg/L) was IFX: 25.9 (26.8), ADA: 18.9 (26.0), UST: 13.5 (17.9), and VDZ: 9.5 (19.0) (Table.1). The initial biologic treatment persistence rates of IFX, ADA, UST and VDZ at 36-months were 77.5%, 75.8%, 79.8%, and 49.0%, respectively (Figure 2). Patients receiving top-down and step-up therapy were 284 (57.0%) and 214 (43.0%), respectively. The treatment persistence rate of initial biologics by top-down and step-up therapy at 36-months from diagnosis was 81.6% and 66.9%, respectively (P=0.001) (Figure 3). Conclusion This registry study that demonstrated the treatment persistence rate of initial biologic therapy was significantly higher in the top-down than the step-up approach.

We developed 16 Mb 1T1R NRAM integrating CNTs resistor elements into the intermediate wirings of 55 nm CMOS. Excellent reliabilities were proven by the retention test at 150 °C extrapolated for 100 kh and the endurance test of 1E6 cycles. The switching speed was realized for cell array at 200 ns. In addition, we successfully fabricated CNTs resistor elements with 49% shrunk small via pitch cell area and realized advantageous high switching speed with 0.5 ns single pulse even omitting verify operation.

Background Information on patient demographics and disease characteristics at the time of Crohn’s disease (CD) diagnosis is considered to be an important aspect in the treatment and management of CD. However, reports on phenotypes, disease course, and treatment impact in newly diagnosed CD patients are limited. An interim analysis of a large registry study was conducted to analyze the clinical characteristics of CD patients at the time of diagnosis. Methods This prospective, non-interventional, observational registry study was conducted at 19 tertiary centers for CD treatment in Japan. Patients newly diagnosed with CD after Jun 2016 based on diagnostic criteria of the Ministry of Health, Labour & Welfare of Japan (age ≥16 years (yrs) at the time of informed consent with no prior exposure to biologics) were enrolled. Patient demographics, diagnostic procedures and categories, disease location and behavior of the lesions (based on Montreal classification) at time of CD diagnosis, were recorded. Results Patients were enrolled between Dec 17, 2018 and Jun 30, 2020, and a total of 672 eligible patients were analyzed; 93.3% (n=627) had definitive diagnosis and 68.2% were men. At the time of diagnosis, median age was 25 (range 13–86) yrs, and peak disease onset was 20–24 yrs. Diagnostic imaging examinations included conventional ileocolonoscopy (542/665, 81.5%), esophagogastroduodenoscopy (413/665, 62.1%), small bowel capsule endoscopy (74/665, 11.1%), balloon-assisted enteroscopy (149/665, 22.4%), CT enterography (74/665, 11.1%), and MR enterography (45/665, 6.8%). Most common disease location was L3 (ileocolonic), followed by, L1 (ileal) and L2 (colonic), 60.1%, 22.7%, and 16.3% of 664, respectively. Nonstricturing/nonpenetrating disease (B1) was most common behavior, followed by stricturing (B2) and penetrating disease (B3), 62.8%, 25.8% and 10.7% of 662, respectively; perianal disease was seen in 48.9% of 662. Interestingly, disease phenotype was different between the different age-at-onset groups (A1 [≤16 yrs], A2 [17–39 yrs], A3 [40–64 yrs], and elderly defined by age of onset ≥65 yrs; Figure 1–3). The male-to-female ratios were also different between these groups (A1: 1.7, A2: 2.6, A3: 1.3 and elderly: 1.3). Conclusion The study provides novel prospective insight on the clinical characteristics of newly diagnosed CD patients. Disease phenotype varied between patients

Our group “ASACUSA MUSASHI” has established an efficient way for accumulating antiprotons and extracting them as intense ultra-slow mono-energetic beams at the CERN-AD facility. This novel beam opens new frontiers for investigating a variety of physics. For realizing H spectroscopy and the test for charge-parity-time symmetry, we have also developed the cusp trap, a combination of an anti-Helmholz superconducting coil and a multi-ring electrode trap, for trapping both antiprotons and positrons and then synthesizing antihydrogens. Recently, the cusp trap was practically used to accumulate antiprotons. The last piece for synthesizing antihydrogens in the cusp trap is the positron accumulator. We have developed a compact system to effectively accumulate positrons based on N2 gas-buffer scheme with a specially designed high precision cylindrical multi-ring electrode trap. The recent progress of the developing work is an important milestone for upcoming antihydrogen science of ASACUSA MUSASHI.

Carbon brushes for automotive starters are used under severe conditions of high electrical current density, high contact pressure and high sliding velocity. Lead has traditionally been added to carbon brushes to improve their performance and durability. Because lead is an environmental hazardous substance, after January 2005 the EU has prohibited adding lead to carbon brushes for electric motors installed in new vehicles. This paper reports the development of the lead-free brush material for the high-load starter. Those brushes are used in much more extreme conditions - at a PV-value (the product of brush contact pressure and sliding velocity) approximately three times that of other starter brushes, and double the electrical current density. The major technical requirement of this development was to decrease the electrical wear in brushes caused by commutation sparking. We developed the brush material that reduces electrical wear by adding a phosphorous compound. Because the phosphorous compound can improve the lubricity at high-temperature and the contact stability of brushes, the developed brush reduces commutation sparks. The life of the developed brush is about 1.5 times longer than that of conventional brushes containing lead.

To explore the aetiology of pathological laughing, a 65-year-old woman with pathological laughing was examined by 3-T functional magnetic resonance imaging (fMRI) before and after treatment with drugs. Here, we report that the patient consistently showed exaggerated pontine activation during the performance of three tasks before treatment, whereas abnormal pontine activation was no longer found after successful treatment with the selective serotonin reuptake inhibitor, paroxetine. Our findings in this first fMRI study of pathological laughing suggest that serotonergic replacement decreases the aberrant activity in a circuit that involves the pons.

Neutron source emission rates are determined by absolute or relative measurement. The relative measurement is performed by comparing between a sample source and a calibrated reference source of the same type. In this calibration, the energy spectra of the sample and reference sources should be identical, since normally there exists energy dependence in the response of neutron detectors. We propose a method of relative calibration of the neutron source emission rate between different source types and spectra. In the present method, a sample source or a calibrated reference source is located at the center of a graphite pile and thermal neutron flux at a special position is monitored and compared. We performed gold foil activation measurements at the NMIJ/AIST graphite pile and revealed that the thermal neutron flux at that position per unit source emission rate is independent of the types of neutron sources. The details of the physical mechanism were examined by calculating the spectral fluence of the neutrons thermalized inside the graphite pile using the MCNP4C code. We demonstrated this method using Am-Be, Ra(/spl alpha/)-Be, Cf, Pu-Be neutron sources and obtained the successful results which agreed within 1%.

TZT-1027 is an antimicrotubule agent targeting beta-tubulin that is undergoing clinical development. The genomic response of cancer cells to TZT-1027 was profiled to evaluate its biochemical activity. A lung cancer cell line, PC-14, was exposed to antimicrotubule agents including dolastatins, Vinca alkaloids and taxanes at an equivalent toxicity level. Alterations in the TZT-1027-induced gene expression of approximately 600 genes were then examined using microarray technology and the resulting gene profiles were compared with those for cells exposed to the other antimicrotubule agents. A principle component analysis using the whole gene set demonstrated that TZT-1027 produced similar gene profiles to those produced by dolastatin 10, but that these gene profiles differed from those produced by other agents. The agents were classified according to their induced genomic response in a molecular structure-dependent manner. Genes whose expression profiles differed according to drug class included intermediate filaments, extracellular matrix protein and Rho regulatory genes that may be involved in cytoskeletal and angiogenesis processes that are regulated by microtubule dynamics. TZT-1027 produces a unique genomic response profile distinct from that of Vinca alkaloids and taxanes, suggesting that this agent has a different mechanism of action. The selected genes may act as pharmacodynamic biomarkers allowing the unique mode of action of TZT-1027 to be discriminated from those of other antimicrotubule agents.

The amygdala is related to recognition of faces and emotions, and functional magnetic resonance imaging (fMRI) studies have reported that the amygdala is habituated over time with repetition of facial stimuli. When subjects are presented repeatedly with unfamiliar faces, they come to gradually recognize the unfamiliar faces as familiar. To investigate the brain areas participating in the acquisition of familiarity to repeatedly presented unfamiliar faces, we conducted an fMRI study in 16 healthy subjects. During the task periods, the subjects were instructed to see presented unfamiliar faces repeatedly and to judge whether the face was male or female or whether the face had emotional valences. The experiment consisted of nine sessions. To clarify the brain areas that showed increasing or decreasing activation as the experimental session proceeded, we analyzed the fMRI data using specified linear covariates in the face recognition task from the first session to the ninth session. Imaging data were investigated on a voxel-by-voxel basis for single-group analysis according to the random effect model using Statistical Parametric Mapping. The bilateral posterior cingulate cortices showed significant increases in activity as the experimental sessions proceeded, while the activation in the right amygdala and the left medial fusiform gyrus decreased. Thus, the posterior cingulate cortex may play an important role in the acquisition of facial familiarity.

The BIOMED I programme Stable Isotopes in Gastroenterology and Nutrition (SIGN) has focused upon evaluation and standardisation of stable isotope breath tests using 13C labelled substrates. The programme dealt with comparison of 13C substrates, test meals, test conditions, analysis techniques, and calculation procedures. Analytical techniques applied for 13CO2 analysis were evaluated by taking an inventory of instrumentation, calibration protocols, and analysis procedures. Two ring tests were initiated measuring 13C abundances of carbonate materials. Evaluating the data it was found that seven different models of isotope ratio mass spectrometers (IRMS) were used by the participants applying both the dual inlet system and the continuous flow configuration. Eight different brands of certified 13C reference materials were used with a 13C abundance varying from δ13CPDB−37.2 to +2.0 ‰. CO2 was liberated from certified material by three techniques and different working standards were used varying from −47.4 to +0.4 ‰ in their δ13CPDB value. The standard deviations (SDs) found for all measurements by all participants were 0.25 ‰ and 0.50 ‰ for two carbonates used in the ring tests. The individual variation for the single participants varied from 0.02 ‰ (dual inlet system) to 0.14 ‰ (continuous flow system). The measurement of the difference between two carbonates showed a SD of 0.33 ‰ calculated for all participants. Internal precision of IRMS as indicated by the specifications of the different instrument suppliers is

We examined a nutritional approach to the therapy of Crohn's disease with an enteral formula ('Enterued', Terumo Corporation, Tokyo, Japan) which contains low molecular weight peptides as a protein source. Total protein, albumin, transferrin, prealbumin and retinol-binding protein levels were significantly increased as indices of the nutritional status, when compared with those observed before treatment. White blood cell count (WBC), erythrocyte sedimentation rate and C reactive protein (CRP) as the indices of inflammation levels were reduced significantly after the termination of the treatment, when compared with those observed before treatment. The International Organization for the Study of Inflammatory Bowel Disease (IOIBD) assessment scores decreased in all cases, except for one case out of 51 cases evaluated. Deterioration in nutritional status was not observed in any patient, but rather was maintained or improved; 42 out of the total 51 cases (82.4%) exhibited at least moderate improvement. Treatment was discontinued on account of side effects such as abdominal distension, abdominal pain and diarrhoea in five cases (8.1%). The enteral formula 'Enterued', utilizing low molecular weight peptides as a nitrogen source, appears to improve nutritional status and encourage remission of the inflammatory process with minimal side effects.

Chlorogenic acid (CGA) is found in many foods, including coffee, berries, potatoes, carrots, wine, apples, and various herbs, and has anti-inflammatory, antidiabetic, and antitumoral actions. The CGA is well absorbed orally, and its effects on gastric ulcer have not been previously reported. The present manuscript evaluated the effect of oral administration of CGA on ethanol/HCl (Et/HCl) or nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcer model in male Swiss mice. Animals were pretreated with 0.2 % carboxymethylcellulose (vehicle, p.o.), omeprazole (positive control, 30 mg/kg, p.o.), carbenoxolone (antioxidant positive control, 100 mg/kg, p.o.), or CGA (5, 25, or 50 mg/kg, p.o.). One hour later, the gastric ulcer was induced by injecting Et/HCl solution (100 μL/10 g body weight; Et 60 % + HCl 0.03 M) or piroxicam (100 mg/kg, p.o). After another hour or 4 h later, gastric tissues were collected from Et/HCl or piroxicam-treated animals, respectively, to evaluate the size of the lesion, histological alterations, secretion of gastric acid, neutrophil migration, oxidative/antioxidative enzymes, markers of lipid peroxidation, or concentrations of inflammatory mediators. CGA treatment had a gastroprotective effect in both models, reducing the percentage of lesioned area. CGA treatment did not alter the secretion of gastric action but inhibited neutrophil migration and restored the levels of catalase, superoxide dismutase, glutathione peroxidase, glutathione, and thiobarbituric acid reactive substances in mice treated with Et/HCl. Additionally, CGA treatment blocked the increase of tumor necrosis factor alpha and leukotriene B4 but did not restore the reduced prostaglandin levels in the NSAID-induced ulcer. Together, the data presented herein show that CGA may be a suitable natural compound for the prevention and treatment of gastric lesions caused by a different etiology.

SUMMARY. Hepatitis C virus (HCV) RNA was tested for, and HCV genotypes determined, in 96 patients with haemophilia A in Japan. Of 88 patients aged ≥ 10 years, 74 (84%) were positive for HCV RNA at a frequency higher than that in patients aged less than 10 years (one of eight, 13%P

大腸絨毛腫瘍の形態学的特徴と発育進展を知る目的で, 外科的切除した11例 (focal cancer 5例, mp以深の進行癌が6例) を対象に摘出標本のmicroangiographyによる血管構築像を解析して検討した。絨毛腺腫の肉眼形態は血管構築像から有茎性ポリープと結節集簇様病変とに大別された.有茎性ポリープの茎部は比較的太い多数のstalk vesselsで構成され, 豊富な血流動態が示唆された.腫瘍血管は繊細で細長く, 絨毛突起の組織像を反映した.結節集簇様病変は基本的にはstalk vesselsを有するポリープが集簇した像で, 進行癌では個々のポリープの破壊・脱落と潰瘍形成がみられた.腫瘤型癌はポリープの基本血管構築像が保たれていた.限局潰瘍型癌は周堤部にstalk vesseslsを有するポリープが集簇し, 潰瘍部は腸壁全層の血管系の改築が著しく, stalk invasionを含めた垂直方向進展が示唆された.絨毛腫瘍の血管構築像を念頭においた臨床的取り扱いの必要性を強調した.

We utilized balloon compression in two cases of arterial hemorrhage from duodenal ulcers. The bleeding was quickly controlled in both cases. The advantages of this technique are its simplicity and ease of performance, and the fact that it does not require precise identification of the bleeding point in the duodenal bulb. No serious complications, such as perforation or stenosis, are associated with this technique. During the healing of the ulcer, balloon expansion may result in decreased duodenal bulb deformity. The following points, however, should be clarified in future studies: a) the stability of the duodenal bulb after longer-term balloon compression, and b) the optimum amount of cold water to be injected into the balloon and the optimum compression time.

The gastric proton pump inhibitor lansoprazole, its active analog AG-2000, and omeprazole dose dependently inhibited urease activity extracted with distilled water from Helicobacter pylori cells; the 50% inhibitory concentrations were between 3.6 and 9.5 microM, which were more potent than those of urease inhibitors, such as acetohydroxamic acid, hydroxyurea, and thiourea. These compounds also inhibited urease activity in intact cells of H. pylori and Helicobacter mustelae but did not inhibit ureases from other bacteria, such as Proteus vulgaris, Proteus mirabilis, and Providencia rettgeri. The mechanism of urease inhibition was considered to be blockage of the SH groups of H. pylori urease, since SH residues in the enzyme decreased after preincubation with lansoprazole and glutathione or dithiothreitol completely abolished the inhibitory action. The SH-blocking reagents N-ethylmaleimide and idoacetamide were also examined for their inhibition of the urease activity; their 50% inhibitory concentrations were 100- to 1,000-fold higher than those of lansoprazole. These results suggest that lansoprazole and omeprazole can potently and selectively inhibit H. pylori urease and that inhibition may be related to earlier findings indicating that these compounds have selective activity against HP growth.

A measurement of the decay K{sup +{yields}{pi}0{mu}+{nu}}{sub {mu}{gamma}}has been performed with the E787 detector at Brookhaven National Laboratory. Forty events were observed in the signal region with the background expectation of (16.5{+-}2.7) events. The branching ratio was measured to be (1.58{+-}0.46(stat.){+-}0.08(syst.))x10{sup -5} in the kinematic region E{sub {gamma}>}30 MeV and {theta}{sub {mu}{gamma}>}20 deg., where E{sub {gamma}}is the energy of the emitted photon and {theta}{sub {mu}{gamma}}is the angle between the muon and the photon in the K{sup +} rest frame. The results were consistent with theoretical predictions.

Serological studies in developed and developing countries using enzyme-linked immunosorbent assays have validated this technique as a rapid, noninvasive method for the diagnosis of Helicobacter pylori infections. The prevalence of serum antibodies to H pylori was studied in 473 Canadian blood donors from Manitoba, 212 healthy Japanese. and 226 healthy Americans. As expected, the seroprevalence rose progressively with age in the three populations and reached its peak (greater than 55%) in subjects 60 years of age and older. The seroprevalence did not decrease in elderly persons (60 to 99 years), indicating a persistent immune response. More detailed analysis was perfom1ed on the Canadian population. Age-adjusted prevalence rates in men and women were similar. Among young adults (15 to 29 years). farmers had a significantly higher seroprevalence rate than white-collar or blue-collar workers. but in older persons occupational rates were similar. A multiple linear regression analysis of the data confirmed that age and occupation in young adults were both significantly associated with seroprevalence of H pylori infections.

A 62-year-old woman who had undergone a left mastectomy for a breast cancer consulted us for an abnormal chest shadow. Chest computed tomography showed a well-defined nodule of 1 cm diameter periphery in lower lobe of the right lung. The differential diagnosis included benign lung tumors, such as intrapulmonary lymph nodes, granuloma etc. However, because of her past history we needed to consider metastasis. To make diagnosis, a wedge resection of the pulmonary nodule was performed. The tumor was diagnosed as a lipoma. No malignant cells were seen. Although peripheral intrapulmonary lipoma is very rare, it should be kept in mind in the differential diagnosis of an intrapulmonary nodule.

Intraosseous ameloblastoma (IA) is the quintessence of epithelial odontogenic tumor and histologically and behaviorally defined as an undoubted neoplastic process. Current information must lead to the consensus that IA arises from the embryologic inclusions of odontogenic epithelium within the jawbone. Nevertheless, clinically oriented evidence is limited to this day.The clinical and radiographic features, behavior, and pathology of 14 cases of small IA confined to the alveolar region were systematically examined.Six cases were a chance finding. There was no gender predilection and half of the lesions clustered in middle age (40 years). The posterior region of the mandible (n = 7) and the anterior segment of the maxilla (n = 4) were favored. Five radiographic characteristics were recognized: interradicular (n = 5) and periradicular (n = 3), and periapical, residual and pericoronal (n = 2 each). They showed solid (n = 12) or unicystic (n = 2) growth pattern and 12 lesions were divided into seven follicular, three desmoplastic, and two plexiform subtypes. The main location of tumor was microscopically traceable in six cases; three interradicular type outside the periodontal ligament space and two periradicular and one periapical variants inside.By in-depth evaluation of the spatial relationship between tumor and its surrounding structure, the alveolar process, periodontal ligament space, and pericoronal area are all the likely starting points of IA. This report re-awakens the oral pathologist to the histogenetic significance of incipient IA as the only available human specimen for reappraisal of their origin.

Our group ASACUSA‐MUSASHI has succeeded in accumulating several million antiprotons and extracting them as monochromatic ultra‐slow antiproton beams (10 eV–1 keV) at CERN AD. We have observed ultra‐slow antiprotons using micro‐channel plates (MCP). The integrated pulse area of the output signals generated when the MCP was irradiated by ultra‐slow antiprotons was 6 times higher than that by electrons. As a long‐term effect, we also observed an increase in the background rate presumably due to the radioactivation of the MCP surface. Irradiating the antiproton beams on the MCP induces antiproton‐nuclear annihilations only on the first layer of the surface. Low‐energy and short‐range secondary particles like charged nuclear fragments caused by the “surface nuclear reactions” would be the origin of our observed phenomena.

We are developing a national standard of a monoenergetic kilo electron volt neutron field with the (45)Sc(p,n)(45)Ti resonance reaction. A wide resonance yields 27.4 keV neutrons at 0 degrees with respect to the proton beam. The proton energy was precisely determined in the measurement of the relative neutron yield as a function of the proton energy from the threshold energy to 2.942 MeV. Absolute measurement of the monoenergetic neutron fluence was performed using a (3)He proportional counter. Relative measurement was also carried out using a Bonner sphere calibrated at our 144 keV standard neutron field. Calibration factors were obtained between the count of a neutron monitor and the neutron fluence. A silicon-surface barrier detector with a (6)LiF foil converter was also being developed for the neutron fluence measurement. Successful results were obtained in the tests in the 144 keV standard neutron field.

This paper describes the 8-MeV neutron field where the neutrons are generated in the (9)Be(alpha,n)(12)C reaction by bombardment of a beryllium target with a 2.4-MeV (4)He(+) beam from a Van de Graaff accelerator. The neutron field is being prepared for a new national standard on neutron fluence in Japan. Absolute measurement of the neutron fluence was taken using a proton recoil neutron detector, consisting of a silicon surface barrier detector with a polyethylene radiator. Neutron spectra were measured using a newly developed recoil proton spectrometer and a liquid organic scintillation detector. The gamma rays existing in the field were also characterised using a liquid organic scintillation detector. The ambient dose equivalents of the gamma rays were estimated to be

The jawbone is replete with a vestige of odontogenesis. The overall consensus is that intraosseous remnants of the enamel organ and dental lamina are the only histogenetic option for central epithelial odontogenic tumors. Curiously, incipient tumors or possible precursor conditions of residual odontogenic epithelium have rarely been reported in the literature.We microscopically evaluated 39,660 biopsy samples to determine the presence of a tumor-like odontogenic epithelial nodule in the maxilla and mandible.Seven intraosseous specimens that associated with a focal proliferation of odontogenic epithelium were retrieved. Six hamartomatous processes showed four different morphologic patterns comparable with the tumor nests comprising ameloblastoma (n = 1), squamous odontogenic tumor (n=1), calcifying epithelial odontogenic tumor (n=2) and calcifying cystic odontogenic tumor (n=2). Among six lesions, four were the intrafollicular development. The remaining case of interest was multiple hyperplastic clear rests of Malassez in association with an impacted tooth.Although it is impossible to predict the fate of these microscopic structures of hamartomatous character, the present case series indicates that any of the dormant embryonic residues of odontogenic epithelium can return to an active state, capable of non-reactive, probably neoplastic proliferation of pathological significance.

In the positioning system of the large-scale high-precision step-stage, the primary resonance mode appears in low frequency even in the high stiffness stage. The resonance mode is a major obstacle of fast and precise positioning. In this paper, we apply vibration suppression PTC (perfect tracking control) which can control the resonance mode actively on the large- scale stage. Finally, simulations and experiments are performed to show the advantages of the vibration suppression PTC.

Precision measurement of nuclear beta decay correlations at newly constructing RIKEN‐RIBF and KEK‐TRIAC is planned. Measurements of beta neutrino correlation and T‐violating electron transverse polarization using spin polarized RI beams are aimed to be performed using slow radioactive nuclei.