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We develop a new method to analyze the total electron content (TEC) depression in the ionosphere after a tsunami occurrence. We employ Gaussian process regression to accurately estimate the TEC disturbance every 30 s using satellite observations from the global navigation satellite system (GNSS) network, even over regions without measurements. We face multiple challenges. First, the impact of the acoustic wave generated by a tsunami onto TEC levels is nonlinear and anisotropic. Second, observation points are moving. Third, the measured data are not uniformly distributed in the targeting range. Nevertheless, our method always computes the electron density depression volumes, along with estimated uncertainties, when applied to the 2011 Tohoku-Oki earthquake, even with random selections of only 5 % of the 1000 GPS Earth Observation Network System receivers considered here over Japan. Also, the statistically estimated TEC depression area mostly overlaps the range of the initial tsunami, which indicates that our method can potentially be used to estimate the initial tsunami. The method can warn of a tsunami event within 15 min of the earthquake, at high levels of confidence, even with a sparse receiver network. Hence, it is potentially applicable worldwide using the existing GNSS network.

Piers can be severely damaged by earthquakes. When an action of a massive earthquake is assumed, the seismic performance of the pier can be improved by widening the foundation width. A previous horizontal loading study indicated that extending only the Foundation Bottom (FB) width, rather than the complete foundation, can boost seismic resilience while suppressing the increase in building cost. However, the research dealt with only two types of FB width, i.e. normal and widened, and the data for sufficiently assessing the inclination angle of the pier with loading were not obtained. In this study, to evaluate the seismic performance of piers with different FB widths in more detail, horizontal loading tests on piers with ordinary columnar foundations and two types of piers with widened FB were conducted, and the seismic resistance of the three pier types were compared. It was shown that horizontal displacement and inclination angle of the pier can be reduced by widening the FB. Furthermore, finite element analysis was carried out to reproduce the experimental results. The analysis results showed good agreement with the experimental results in terms of pier horizontal displacement and inclination angle.

Structures are subjected to vertical and horizontal loads. Vertical subgrade reaction acts on the foundation bottom surface, and in the case of an embedded structure, horizontal subgrade reaction acts on the embedded part. The subgrade reaction is obtained by multiplying the displacement of the foundation by the Subgrade Reaction Modulus (SRM). In practice, SRM is calculated using an equation that incorporates the negative power relationship of the Foundation Width (FW). If the structure is evaluated to be poorly seismic resistant, it is necessary to widen FW. However, when the FW is widened, the design value of SRM decreases. In this case, it is not possible to expect an increase in the subgrade reaction proportional to the increase of FW. Therefore, when the inertia force is very high, the FW has to be very wide. However, underestimating SRM can lead to structural overdesign. In this study, the relationship between SRM and FW, for a structure in which vertical and horizontal load act simultaneously, was analyzed. Compared with the design practice assumptions, the horizontal SRM was found to be highly dependent on FW while the vertical SRM was shown to be less dependent on FW.

Objectives: This study aimed to determine whether texture analysis of positron emission tomography (PET) images from patients with oral squamous cell carcinoma (OSCC) can accurately diagnose cervical lymph node (LN) metastases. Methods: We conducted a retrospective chart review of 166 patients with newly pathologically diagnosed OSCC. The patient inclusion criteria were LNs exhibiting high 18F-fluorodeoxyglucose uptake [maximum standardised uptake value (SUVmax) ≥2.5] and/or LNs diagnosed as metastatic cervical LNs by a board-certified nuclear medicine physician, irrespective of the SUVmax value. The patient exclusion criteria were LNs with a metabolic tumour volume (MTV) of ≤1.0 cm3. The primary predictor variables were 31 textural indices, SUVmax and MTV. The diagnostic performance was evaluated by receiver operating characteristic (ROC) curve analysis. Results: Analyses of 91 cervical LNs (48 positives, 43 negatives) indicated that long-run emphasis (LRE) could demonstrate the highest area under the ROC curve (AUC) of 0.809. Comparison of the AUCs between SUVmax and LRE indicated that the AUC of LRE was marginally higher than that of SUVmax (p = 0.067). Furthermore, the diagnostic performance of the combination of SUVmax and LRE was more accurate than that of SUVmax alone (p = 0.04). Conclusions: The combination of SUVmax and LRE may improve the diagnostic accuracy of determining cervical LN metastases.

Seismic design is the preparation for earthquake ground motions considering the seismicity and seismic amplification properties of the ground at the target site. However, the effects of source, path, and site amplification characteristics are not sufficiently anticipated in seismic codes. Regarding the source and path characteristics, earthquakes that have the strongest influence on the target site should be considered specifically, and, concerning seismic amplification, the effects of not only a shallow subsurface but also a deep subsurface should be considered. This article takes the design spectra of Japanese highway bridges as an object and compares them with the spectra produced by a ground motion prediction equation and the source- and site-specific spectra evaluated using a state-of-the-art method. The results show that the spectra differ greatly. In this way, the necessity of the application of a state-of-the-art technique in the evaluation of source, path, and site amplification characteristics is demonstrated.

The resistance of a pier to horizontal loads, like seismic loads, is due to the flexural rigidity of its foundations and the horizontal subgrade reaction. In the event of a massive earthquake, the latter becomes very small because of the softening of the ground, while the structure may experience a large inertial force and lateral spreading pressure. Therefore, structures with high seismic resistance are required in areas with high seismicity. When a wide caisson is used as a pier foundation, a rotational resistance moment caused by the vertical subgrade reaction acting on the foundation bottom can be expected. Although this rotational resistance moment increases if the foundation is widened, in design practice the subgrade reaction coefficient is evaluated as being low under such circumstances. Therefore, even if the foundation is widened, the rotational resistance moment does not increase greatly. Rotational resistance commensurate with the increased construction cost due to foundation widening cannot be expected. In the present study, horizontal loading experiments were performed at one pier with a normal foundation and at one with widened at the bottom foundation, and the way that the widening affected the seismic performance was examined. The results show that compared with the normal foundation, the bottom-widened one experienced far less displacement and offered higher earthquake resistance.

Codes of practice and ground motion prediction equations involve ground structure proxies to account for seismic amplification. Although the ground consists of both shallow and deep subsurface, proxies are mainly related to the shallow subsurface as it is shallow subsurface information that is mostly available. However, as deep subsurface seismic amplification is not negligible, it may not be appropriate to use shallow subsurface proxies. In this study, the relationship between shallow and deep subsurface seismic amplification factors is discussed on the basis of S-wave velocity profile data from Japanese KiK-net strong-motion observation system stations. The correlation between typical proxies such as the average S-wave velocity of the top 30m of the ground surface and the seismic amplification factor was examined. Although there was a negative correlation between the two, the degree of the correlation was weak. A new proxy showing stronger correlations with the seismic amplification factor is proposed and its effectiveness is demonstrated.

The considered parameters in seismic design vary, with the Earthquake Ground Motion (EGM) having the largest variation. Since source characteristic, path characteristic, and Site Amplification Factor (SAF) influence the EGM, it is crucial to appropriately consider their variations. Source characteristic variations are mainly considered in a seismic hazard analysis, which is commonly used to evaluate variations in EGM. However, it is also important to evaluate variations in path characteristic and SAF with only a few studies having individually and quantitatively examined the variations of these two characteristics. In this study, based on strong-motion observation records obtained from four sites in central Japan, the three characteristics were extracted from seismograms using the concept of spectral inversion. After removing the source characteristic, the path characteristic and SAF were separated, and the variations in these two characteristics were quantified. To separate and obtain each characteristic from the observed record, one constraint condition must be imposed, whereas the variations in the constraint condition must be ignored. In that case, the variations in the constraint condition are included in the variations of the separated characteristics. In this study, this problem was solved by evaluating the variation in the constraint condition, which is the SAF at a hard rock site, by the use of the vertical array observation record at the site.

In a seismic design of embedded foundations, the vertical Subgrade Reaction (SR) acting on a foundation bottom surface and the Rotational Resistance Moment (RRM) generated by the SR are calculated using an SR Modulus (SRM). The SRM and RRM depend on both ground rigidity and Foundation Width (FW). However, the SRM and RRM calculation methods adopted in design codes might not properly consider their FW dependency. In this study, SRM and RRM evaluation methods for embedded foundations subjected to a seismic load were examined by conducting a two-dimensional finite element analysis under the condition where ground rigidity and FW were changed considering the nonlinearity of the ground. The results show that when the seismic load is large and the nonlinearity of the ground appears, the SR distribution is different from the assumption in the design code. The FW dependency of the SRM was lower than the assumption of the design code. Furthermore, methods to calculate the SRM and RRM in accordance with the FW and ground rigidity are proposed.

We evaluated whether texture analysis of positron emission tomography (PET) scans could predict the response to induction chemotherapy (ICT) in patients with oral squamous cell carcinoma (OSCC). Our retrospective cohort study included 21 patients with OSCC who underwent ICT. We extracted 31 textural indices from pretreatment PET scans and performed receiver operating characteristic curve (ROC) analysis to evaluate these indices’ efficacy in predicting ICT response. The area under the ROC curve was statistically significant for one texture index: short-zone emphasis (SZE; p = 0.041).

Since an Earthquake Ground Motion (EGM) is amplified from the propagation through the ground, different models are required for each ground type in the seismic design of structures. While the shallow subsurface indicators are used for the classification of ground types, a deep subsurface has a significant impact on the amplification of the EGMs. This study discusses the maximum credible EGMs for seismic design reflecting seismic amplification due to deep subsurface. The design spectra, reflecting the site amplification factor of the target location, are presented by the calculation of the EGMs with the same source and path characteristics and different site amplification factors as recent major Japanese earthquake records have shown, from the perspective of establishing the maximum credible EGMs that may occur in the future at a target site. The present design spectra, which are based on the natural period of a shallow subsurface, are compared with those based on the site amplification factors, considering the effect of deep subsurfaces. Although there are almost no differences in the design spectra with the present design methods according to the surface ground type, the proposed method provides significantly different design spectra for each site amplification factor.

In the seismic design of pile foundations, the safety of the pile is assessed by considering the inertial force during an earthquake and subgrade reaction as external forces against the pile. The amount of deformation of the pile must be limited to a small value to maintain the safety of the pile. In the event of a large earthquake, quay walls and seawalls are subjected to lateral spreading because of the influence of biased seaward earth pressure. The amount of lateral spreading is considerably larger than what can be expected in a typical pile seismic design and may reach several meters. In this study, loading experiments that reproduced lateral spreading were conducted to evaluate the lateral spreading pressure acting on a pile when considerably large lateral spreading occurred. The experiment results showed that lateral spreading pressure depended on the ratio of pile spacing to pile diameter while the peak value of lateral spreading pressure was larger than the one assumed in practical design.

Observations from the new Japanese geostationary satellite Himawari-8 permit quasi-real-time estimation of global shortwave radiation at an unprecedented temporal resolution. However, accurate comparisons with ground-truthing observations are essential to assess their uncertainty. In this study, we evaluated the Himawari-8 global radiation product AMATERASS using observations recorded at four SKYNET stations in Japan and, for certain analyses, from the surface network of the Japanese Meteorological Agency in 2016. We found that the spatiotemporal variability of the satellite estimates was smaller than that of the ground observations; variability decreased with increases in the time step and spatial domain. Cloud variability was the main source of uncertainty in the satellite radiation estimates, followed by direct effects caused by aerosols and bright albedo. Under all-sky conditions, good agreement was found between satellite and ground-based data, with a mean bias in the range of 20–30 W m−2 (i.e., AMATERASS overestimated ground observations) and a root mean square error (RMSE) of approximately 70–80 W m−2. However, results depended on the time step used in the validation exercise, on the spatial domain, and on the different climatological regions. In particular, the validation performed at 2.5 min showed largest deviations and RMSE values ranging from about 110 W m−2 for the mainland to a maximum of 150 W m−2 in the subtropical region. We also detected a limited overestimation in the number of clear-sky episodes, particularly at the pixel level. Overall, satellite-based estimates were higher under overcast conditions, whereas frequent episodes of cloud-induced enhanced surface radiation (i.e., measured radiation was greater than expected clear-sky radiation) tended to reduce this difference. Finally, the total mean bias was approximately 10–15 W m−2 under clear-sky conditions, mainly because of overall instantaneous direct aerosol forcing efficiency in the range of 120–150 W m−2 per unit of aerosol optical depth (AOD). A seasonal anticorrelation between AOD and global radiation differences was evident at all stations and was also observed within the diurnal cycle.

In this paper, an evaluation of the variation of earthquake ground motions with a focus on site amplification factors based on spectral analysis is presented. By using strong motion record obtained at six sites in Japan, probability distributions of site amplification factors were shown. The relations between standard deviations of site amplification factors and distances between the sites were studied. The variations of representative values of earthquake ground motions based on the variations of site amplification factors were discussed by using probabilistic seismic hazard analysis with focus on Fourier amplitude and group delay time. The distributions of peak ground accelerations and peak ground velocities were shown. It is suggested that design earthquake ground motions considering the average site amplification factors may lead the engineering design on the dangerous side.

For the prediction of the expected Tokai Earthquake (EQ), Japan Meteorological Agency (JMA) has been observing volumetric strain changes to detect its presumed pre-slip phenomena in Tokai and South Kanto regions. In 1998, an anomalous volumetric strain change, lasting for 5 days, which initially attracted much attention as a possible precursor to the Tokai EQ, was observed at Shimizu station in the Tokai area. Eventually, the Tokai EQ did not occur and the causal mechanism of the observed anomaly was unknown. However, we found variations of geoelectric potential differences (GPD) possibly associated with the anomaly by applying Principal Component Analysis (PCA) to the GPD data taken in the same area. From the polarities of the observed GPD changes, we infer that these GPD variations were caused by electrokinetic effects of groundwater motion, which might have been related with the strain changes. These results imply that the GPD observations may assist us in understanding the nature of EQ precursory phenomena.

Ce3+, Eu3+ ions singly doped, and Ce3+/Eu3+ codoped bismuth phosphate (BiPO4) nanophosphors were synthesized by a simple precipitation method and their structural, morphological, and photoluminescence properties were investigated. The structural and morphological analysis confirms the pure hexagonal crystal structure of the synthesized nanophosphors. From the Fourier transform infrared (FTIR) spectra various absorption bands respective to functional groups such as PO4 and phonon vibrations including the bending modes of the PO4 units are identified. The Ce3+ doped nanophosphors show spectrally broad luminescence in the blue (centred at 459 nm) wavelength region under the direct optical excitation of Ce3+ at 417 nm. For Eu3+ doped nanophosphors, five emission bands have been observed with 394 nm excitation wavelength. Among them, 595 nm has shown bright yellowish-orange emission. These results demonstrate that by appropriately tuning the excitation wavelength of these codoped nanophosphors the emission color in the visible region (blue and orange) can be flexibly controlled in a single sample without varying its chemical composition and size. The mechanism for this excitation energy dependent tunable emission is explained on the basis of nonenergy transfer (ET) occurring among Ce3+/Eu3+ dopant ions.

OBJETIVO: Estudar a produção de anticorpos a antígenos polissacarídicos em pacientes com ataxia-telangiectasia CASUÍSTICA E MÉTODO: Utilizando a técnica de ELISA, determinamos os níveis de IgG aos sorotipos 1, 3, 5, 6B, 9V e 14 do pneumococo em 14 pacientes com ataxia-telangiectasia, antes e após a imunização com a vacina pneumocócica 23-valente. Resposta adequada a cada sorotipo foi definida como IgG > 1,3 µg/ml ou o incremento de quatro vezes dos níveis pós em relação aos pré-imunização. RESULTADOS: Seis pacientes (43%) não responderam a todos os sorotipos analisados, quatro a apenas um sorotipo, um paciente a dois, dois a três e apenas um paciente a quatro dos seis sorotipos analisados. Nenhum paciente apresentou resposta adequada a todos os sorotipos testados. Os níveis de IgG ao pneumococo pós-imunização foram superiores aos pré-imunização para todos os sorotipos testados, exceto o 3. Apesar disso, os valores médios pós-imunização foram inferiores a 1,3 µg/ml para todos os sorotipos analisados, exceto o 14. A média de incremento da resposta foi inferior a quatro para todos os sorotipos analisados. CONCLUSÃO: Nossos resultados sugerem que pacientes com ataxia-telangiectasia têm grande risco de apresentar resposta inadequada ao pneumococo, o que pode ser uma das causas das infecções sinopulmonares de repetição.OBJECTIVE: To analyze the production of antibodies to polysaccharide antigens in patients with ataxia-telangiectasia. PATIENTS AND METHODS: We used the ELISA technique to measure the levels of IgG antibodies to serotypes 1, 3, 5, 6B, 9V and 14 of Streptococcus pneumoniae in 14 patients with ataxia-telangiectasia before and after immunization with 23-valent polysaccharide vaccine. Adequate response to individual polysaccharide can be defined as a postimmunization antibody titer equal to or greater than 1.3 µg/ml or as a minimum fourfold increase over the baseline (preimmunization) value. RESULTS: Six (43%) patients showed an absent response to all serotypes analyzed. Four patients showed adequate response to only one serotype, one patient to two serotypes, two patients to three serotypes and only one patient to four out of six serotypes analyzed. No patient had adequate response to all serotypes tested. Postimmunization pneumococcus IgG levels were higher than preimmunization levels to all serotypes analyzed, except for serotype 3. In spite of this, the mean postimmunization levels were lower than 1.3 µg/ml in all serotypes, except for serotype 14. Mean increment was less than four in all serotypes analyzed. CONCLUSION: Our results suggest that patients with ataxia-telangiectasia are at a high risk of having an impaired response to pneumococcus, which may be one of the causes of recurrent sinopulmonary infections in these patients.

OBJETIVO: Rever as publicações recentes mais relevantes sobre alergia medicamentosa e oferecer ao clínico subsídios para uma maior compreensão dessa problemática de grande relevância para a saúde pública. FONTES DOS DADOS: Busca de artigos originais e revisões indexados nas bases MEDLINE, Pubmed e Lilacs, publicados na última década, relacionando o tema de alergia a medicamentos com mecanismos imunológicos, epidemiologia, diagnóstico laboratorial, lesões cutâneas, manejo clínico e reexposição ao fármaco. SÍNTESE DOS DADOS: As reações alérgicas representam um terço das reações adversas a medicamentos. São consideradas eventos raros, mas com elevada morbimortalidade. Apesar da descrição de Gell & Coombs, útil para classificar reações alérgicas a fármacos, algumas permanecem sem classificação devido ao desconhecimento dos mecanismos imunológicos envolvidos. A existência de subpopulações de células T com características diversas daquelas comumente descritas revela a complexidade do tema e, ao mesmo tempo, elucida inúmeras questões inerentes ao mesmo. Recentemente, um novo conceito de apresentação de fármaco a linfócitos T surgiu, diante de evidências crescentes do seu envolvimento nas lesões cutâneas decorrentes de reações alérgicas a medicamentos. Na prática clínica, é muito difícil a correlação de sinais e sintomas das reações alérgicas a medicamentos com o mecanismo imunológico envolvido sem o auxílio de testes laboratoriais. Testes cutâneos in vivo e testes in vitro têm sido empregados nas suspeitas de reações alérgicas a medicamentos. No entanto, há poucos produtos comerciais adequados para sua execução. CONCLUSÕES: As reações alérgicas a fármacos constituem uma fração importante dos eventos adversos a medicamentos. É importante enfatizar a necessidade de notificação dessas reações pelos profissionais envolvidos no tratamento do paciente de forma sistematizada, por meio de ações de farmacovigilância, bem como a identificação dos possíveis mecanismos imunológicos envolvidos através de testes laboratoriais, história e avaliação clínica detalhadas.OBJECTIVE: This review addresses the most recent published literature regarding drug allergy, in order to provide physicians with a background for a better understanding of this problem of great relevance for public health. SOURCES OF DATA: The sources of data for obtaining the original and review articles published in the last 10 years were MEDLINE, Pubmed and Lilacs. The articles chosen for this review relate drug allergy to immunological mechanisms, epidemiology, clinical and laboratory evaluation, skin lesions, clinical management, and re-exposure to the drug. SUMMARY OF THE FINDINGS: Allergic reactions represent one third of adverse drug reactions. They are considered rare but with high morbimortality. Gell & Coombs' definition has been useful for classifying some types of drug allergic reactions; however, some still remain without classification because of poor knowledge of the mechanisms involved. The existence of T cell subpopulations with diverse characteristics reveals the complexity of the subject and, at the same time, elucidates several questions raised about it. It was recently postulated a new concept of chemically inert drug presentation to T cells, restricted to the major histocompatibility complex, but in a non-covalent and labile way. In clinical practice, without adequate laboratory tests, it is difficult to correlate clinical symptoms and immunological mechanisms. In vitro and in vivo skin tests have been employed in cases of suspected drug allergy reaction. However, there are very few commercially available reagents. CONCLUSIONS: Drug allergy constitutes an important problem in adverse drug reactions because of its potential of morbidity and mortality. It is necessary to emphasize the relevance of pharmacovigilance during treatment of patients, as well as the identification of possible immunological mechanisms involved in the events, through laboratory tests and detailed history and clinical evaluation.

A review of data processing of electromagnetic emission observation collected at the Complex Geophysical Observatory Karimshino (Kamchatka peninsula) during the first 5 months (July–November, 2000) of its operation is given. The main goal of this study addresses the detection of the phenomena associated with Kamchatka seismic activity. The following observations have been conducted at CGO: variations of ULF/ELF magnetic field, geoelectric potentials (telluric currents), and VLF signals from navigation radio transmitters. The methods of data processing of these observations are discussed. The examples of the first experimental results are presented.

Regular monitoring of some geophysical parameters in association with seismicity has been carried out since last year at the Japan-Russian Complex Geophysical Observatory in the Kamchatka region. This observatory was organized in connection with the ISTC project in Russia and was motivated by the results of the FRONTIER/RIKEN and FRONTIER/NASDA research projects in Japan. The main purpose of the observations is to investigate the electromagnetic and acoustic phenomena induced by the lithosphere processes (especially by seismic activity). The seismicity of the Kamchatka area is analyzed and a description of the observatory equipment is presented. At present, the activity of the observatory includes the seismic (frequency range ∆F = 0.5 – 40 Hz) and meteorological recordings, together with seismo-acoustic (∆F = 30 – 1000 Hz) and electromagnetic observations: three-component magnetic ULF variations ( ∆F = 0.003 – 30 Hz), three-component electric potential variations ( ∆F < 1.0 Hz), and VLF transmitter’s signal perturbations ( ∆F ~ 10 – 40 kHz).

The sensitivity in surface enhanced infrared spectroscopy (SEIRS) strongly depends on where the resonant excitation is spectrally located compared to the molecular vibration that is to be enhanced. In this contribution, we study the effect of coupling in the electromagnetic properties of 2D gold nanorod arrays in the IR. We also study the SEIRS activity of higher order resonant excitations in long nanoantennas to identify polaritonic signals of a supporting SiO2 layer with nanometer thickness (3 nm) on a silicon substrate.