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1. <scp>Anti‐BP180</scp> , pruritus, and thymus and activation‐regulated chemokines as surrogate markers for disease activity in bullous pemphigoid

Author

S. Wada, T. Komori, C.S. de Jesus, T. Nomura, T. Komura, S. Yonekura, R. Shibuya, E. Adachi, Y. Sakurai, M. Ishikawa, S. Usui, N. Kambe, and K. Kabashima

Subjects
Infectious Diseases, Pruritus, Pemphigoid, Bullous, Humans, Dermatology, Non-Fibrillar Collagens, Chemokines, Autoantigens, Biomarkers, Autoantibodies
Published
2022
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2. X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

Author

S. Abiru, John F. Dillon, Yasuhiro Miyake, Piero Portincasa, Giancarlo Spinzi, R. Harvey, T. Ngatchu, Agostino Colli, M. Taniai, K. Flahive, Masanori Abe, B. Hoeroldt, S. Holder, Howard Curtis, María Isabel Colombo, C. MacNicol, Gang Xie, Andrew Chilton, H. Hussaini, Cristina Rigamonti, M. Kato, Shintaro Yagi, G. Abouda, D. Tyrer, Chris D. Evans, Christopher I. Amos, K. Koss, Kazuaki Chayama, P. Premchand, K. Migita, Simon Panter, Marco Marzioni, Silvia Colombo, Konstantinos N. Lazaridis, M. Yagura, Ashley Brown, D. Gocher, Domenico Alvaro, K. Murata, Mark Wright, Piero Luigi Almasio, C. Healey, A. Ciaccio, N. Wheatley, Vincenzo Cardinale, T. Delahooke, Chiara Milani, T. Shewan, W. Stableforth, S. Levi, Mark L. Green, James V. Jones, Y. Baird, Aftab Ala, Burroughs Ak, D. Williams, K. Ario, P. Sanghi, Hemant Gupta, P. Southern, L. Farrington, M. Hamilton, Andrew D. Higham, I. Yabuuchi, H. Yatsuhashi, Lorenzo Morini, T. Yamamoto, Douglas Thorburn, M. Carnahan, N. Nishida, Susan Slininger, M. Koga, K. Honda, Annarosa Floreani, Andrew Douglass, K. Netherton, M. Yasunami, Hirohito Tsubouchi, F. Donato, K. Walker, U. Shmueli, Paolo Muratori, Ray Mathew, J. Maiden, E. Dungca, Subramaniam Ramakrishnan, S. Vyas, Helen Sweeting, Subrata Saha, T. Komeda, T. Komatsu, H. J. Lee, Maria Consiglia Bragazzi, T. Komura, C. Thomas, C. Shallcross, C. Duggan, J. Kordula, F. Muscariu, Lourdes Cumlat, Imran Patanwala, Giulia Cardamone, L. Morgan, J. Brighton, Masao Honda, H. Nakamura, David Jones, Raj Srirajaskanthan, M. E. Gershwin, T. Muro, L. Stafford, N. Fukushima, Graham P. Butcher, Andrea Crosignani, George Lipscomb, K. Hirata, Y. Nagaoki, S. Mann, Paul G. Richardson, David A Elphick, M. Mupudzi, Y. Ohara, E. Grieve, Gayle Clifford, Claudio Tiribelli, M. Quinn, G. Van Duyvenvoorde, E. Archer, Tatsuki Ichikawa, J. Maltby, T. Arinaga-Hino, Simon Williams, A. King, Yasuni Nakanuma, H. Doyle, A. Brind, Nora Cazzagon, H. Ota, Daphne D’Amato, K. Hogben, H. Wooldridge, J. Wilkins, Shuichi Kaneko, L. Hankey, Gordon Wood, Andrew Fraser, K. Martin, A. Naqvi, M. Ninkovic, M. Patel, Yoshihiko Maehara, Kapil Kapur, I. Amey, Vincenza Calvaruso, Kenichi Harada, T. Yamashita, James Neuberger, N. Taylor, T. Lee, J. Featherstone, C. Lawlor, K. Seward, Satoshi Yamagiwa, Andrea Galli, L. Tan, Kentaro Kikuchi, K. Furuta, Mark A. Ainsworth, Hiromasa Ohira, Esther Unitt, Yosuke Kawai, N. Lancaster, D. Simpson, R. Shidrawi, I. Salam, A.J. Bell, Pietro Andreone, J. Ishida, Voi Shim Wong, N Fisher, Andrew C. Douds, R. Penn, Matthew Foxton, A. Watson, Andrew Mason, S. Walsh, Hiromi Ishibashi, Daniel M. Forton, Giovanni Casella, H. Takaki, K. Yamauchi, Pietro Lampertico, Osamu Yokosuka, M. Koda, M. Davies, H. Mitchison, P. Gyawali, G. Bird, M. Hughes, L. Jones, C. Hamilton, A. Hynes, R. Galaska, Fabio Marra, Debasish Das, C. Cowley, A. Fouracres, Yasuhiko Sugawara, E. Mita, T. Saoshiro, Akinobu Taketomi, Robert P. Myers, R. Przemioslo, F. Wright, L. Hobson, L. Currie, J. Allison, J. Hails, Noriyo Yamashiki, Massimo Zuin, C. Grimley, Alessio Gerussi, S. Besley, Stefano Duga, A. Piotrowicz, H. Kouno, L. Dali-kemmery, H. Sakai, M. Mizokami, Stefano Fagiuoli, Amy Davis, Pier Maria Battezzati, Masao Nagasaki, Luigi Muratori, A. Mori, S. Desmennu, S. Jones, R. Abrahams, Keith George, F. Makita, J. Brown, D. Gorard, Satoru Joshita, M. Mills, Pierluigi Toniutto, S. Campbell, J. Butterworth, S. Dyer, Filomena Morisco, Norihiro Kokudo, T. Yapp, C. Shorrock, Floriano Rosina, E. Walker, Shinji Uemoto, H. Takahashi, Simon M. Rushbrook, K. Amor, E. Marshall, J. Browning, S. Batham, Luca Fabris, Paul R. Banim, Meenakshi Narain, M. Harada, Dermot Gleeson, N. Hirashima, M. Kikuchi, T. Nikami, Gideon M. Hirschfield, Carlo Ferrari, G. Prasad, O. Chirag, Katsushi Tokunaga, M. Nasseri, Rosanna Asselta, Y. Lu, Ken Shirabe, D. Sirdefield, George F. Mells, K. Sugi, R. Ayres, G. Whatley, A. Singhal, M. Leoni, N. Sivaramakrishnan, T. Harding, Rupert Ransford, Anton V J Gunasekera, C. Mulvaney-Jones, D. Ramanaden, M. Mendall, Muhammad F. Dawwas, Dave Jones, Luca Valenti, Earl J. Williams, Markus Gess, Peter Bramley, A. McNair, E. Hashimoto, P. Townshend, C. Ford, Mario Strazzabosco, Luca Miele, Matthew J Brookes, J. Colley, Mark Wilkinson, H. Dewhurst, Charles Millson, E. Shpuza, Shinji Shimoda, T. Himoto, P. Kitchen, M. Nakamuta, Hiroaki Nishimura, Martin Lombard, Kevork M. Peltekian, M. Pitcher, G. Lim, L. Graves, C. Palmer, S. Lord, S. Katsushima, S. Tripoli, Andrew Austin, N. White, B. Grover, S. Congreave, M. Prince, Rebecca Jones, K. Hirano, A. Shepherd, Y. Mano, Michael A. Heneghan, Richard Sandford, L. O'Donohoe, Marco Carbone, S. A. Rolls, Patrick Goggin, M. L. Cowan, M. Crossey, A. Loftus, K. Young, Mesbah Rahman, Cameron N. Ghent, E. Nambela, M. Xiong, L. Grellier, Sunil Dolwani, Antonio Picciotto, Gill Watts, Alberto Mattalia, Elvezia Maria Paraboschi, J. Orpe, Takeji Umemura, Yuki Hitomi, Fiona H. Gordon, Shotaro Sakisaka, A. Dias, Chin Lye Ch'ng, M. Carter, A. Mandal, Yufang Shi, Takafumi Ichida, N. Masaki, M. Oblak, S. Nagaoka, Kevin Yoong, O. Gervais, Minoru Nakamura, Kazuhiko Nakao, S. Taylor-Robinson, L. Kent, Sushma Saksena, A. Affronti, K. Boulton, R. Ede, H. Pateman, K. Yoshizawa, G. Bray, H. Ebinuma, Yeng Ang, Akio Ido, John Ramage, Richard Sturgess, C. Gray, E. Durant, M. Hayes, A. Saeed, J. Keggans, J. Gitahi, T. Valliani, Edoardo G. Giannini, C. Foale, A. Palegwala, Lory Saveria Crocè, K. Matsushita, S. Shaukat, J. Mclindon, S. Pearson, A. Barnardo, A. Wright, Mirko Tarocchi, R Marley, M. Kent, C. Dickson, A. Gibbins, J. Whiteman, S. Singhal, Richard Aspinall, M. Ito, Laura Cristoferi, Maurizia Rossana Brunetto, J. Booth, A. Bathgate, Morikazu Onji, A. Grant, A. Paton, Y. Aiba, P. Chan, J. Sayer, S. Whalley, T. Mathialahan, J. Gotto, T. Kanda, B. Williams, K. Elliott, P. Raymode, Akinobu Takaki, V. Silvestre, I. Gee, C. Hovell, Graham R. Foster, D. Cotterill, G. Stansfield, Grazia Anna Niro, J. Conder, Yoshiyuki Ueno, A. Shah, Jane Metcalf, S. Hayashi, T. Sato, S. Jain, J. Subhani, Donatella Barisani, A. McKay, Kuniaki Arai, Jeremy Shearman, Torao Tanaka, S. Glenn, S. E. O'Donnell, Federica Malinverno, Denise O'Donnell, R. Casey, N. Sharer, J. Bowles, J. Kendall, Maria Cristina Vinci, Antonio Benedetti, George MacFaul, K. Houghton, Vincenzo Ronca, P. Desousa, B. Holbrook, F. Ali, B. Longhurst, Atsushi Tanaka, Marek Czajkowski, R. Tang, Kazuhide Yamamoto, Y. Watanabe, Graeme J.M. Alexander, R. Cloudsdale, F. Hines, M. Karmo, Brian D. Juran, I. Gooding, Y. Takeyama, J. Fraser, A. Mukhopadhya, Sumihito Tamura, Hajime Takikawa, R. Damant, E. Wilhelmsen, M. Kobayashi, J. Tregonning, V. Lambourne, D. Clement, D. Braim, M. Shimada, S. Sen, Shaun Greer, C. Innes, E. Gunter, C. Brown, H. Klass, A. Komori, Andy Li, H. Fairlamb, N. Ncube, Yoshinori Shimada, M. Harrison, S. Marriott, I. Grattagliano, Savino Bruno, A. Naganuma, Xiangjun Gu, Michael F. Seldin, S. Thornthwaite, Peter R. Mills, Katherine A. Siminovitch, X. Liu, Masataka Seike, J. Curtis, Carmela Cursaro, Z. Li, Mikio Zeniya, K. Warner, B. Bird, Jane Collier, Bridget Gunson, S. Tsuruta, E. Tanqueray, Richard Evans, H. Kamitsukasa, R. Sugimoto, Jeremy Tibble, D. Neal, S. Ducker, Francesco Azzaroli, K. Spurdle, K. Ocker, M. Senju, C. Collins, Y. Nakamura, Matthew E. Cramp, Yuji Soejima, I. Drake, K. Ueno, T. Mannami, Clara Mancuso, M. Kawashima, M. Cox, S. S. Kohn, H. Shibata, Stephen D. Ryder, Christopher Macdonald, J. Ridpath, Stephen P. Pereira, L. March, Barbara Coco, J. Morrison, A. Broad, J. Verheyden, Angelo Andriulli, N. Higuchi, J. Musselwhite, R. Bishop, Gwen Baxter, Richard A. Miller, Guido Colloredo, A. Eastick, I. Rees, Deb Ghosh, L. Winter, Sara Massironi, R. McCorry, Gianfranco Elia, T. Kobata, N. Naeshiro, K. Pollock, J. Gasem, S. Gallagher, K. Jing, S. Misra, B. Shinder, Harriet Gordon, E. Takesaki, J. Sadeghian, S. Tsunematsu, Ana Lleo, M. Aldersley, Elizabeth J. Atkinson, Pietro Invernizzi, Heather J. Cordell, Asselta, R., Paraboschi, E. M., Gerussi, A., Cordell, H. J., Mells, G. F., Sandford, R. N., Jones, D. E., Nakamura, M., Ueno, K., Hitomi, Y., Kawashima, M., Nishida, N., Tokunaga, K., Nagasaki, M., Tanaka, A., Tang, R., Li, Z., Shi, Y., Liu, X., Xiong, M., Hirschfield, G., Siminovitch, K. A., Walker, E., Xie, G., Mason, A., Myers, R., Peltekian, K., Ghent, C., Atkinson, E., Juran, B., Lazaridis, K., Lu, Y., Gu, X., Jing, K., Amos, C., Affronti, A., Brunetto, M., Coco, B., Spinzi, G., Elia, G., Ferrari, C., Lleo, A., Muratori, L., Muratori, P., Portincasa, P., Colli, A., Bruno, S., Colloredo, G., Azzaroli, F., Andreone, P., Bragazzi, M., Alvaro, D., Cardinale, V., Cazzagon, N., Rigamonti, C., Floreani, A., Rosina, F., Ciaccio, A., Cristoferi, L., D'Amato, D., Malinverno, F., Mancuso, C., Massironi, S., Milani, C., O'Donnell, S. E., Ronca, V., Barisani, D., Lampertico, P., Donato, F., Fagiuoli, S., Almasio, P. L., Giannini, E., Cursaro, C., Colombo, M., Valenti, L., Miele, L., Andriulli, A., Niro, G. A., Grattagliano, I., Morini, L., Casella, G., Vinci, M., Battezzati, P. M., Crosignani, A., Zuin, M., Mattalia, A., Calvaruso, V., Colombo, S., Benedetti, A., Marzioni, M., Galli, A., Marra, F., Tarocchi, M., Picciotto, A., Morisco, F., Fabris, L., Croce, L. S., Tiribelli, C., Toniutto, P., Strazzabosco, M., Ch'Ng, C. L., Rahman, M., Yapp, T., Sturgess, R., Healey, C., Czajkowski, M., Gunasekera, A., Gyawali, P., Premchand, P., Kapur, K., Marley, R., Foster, G., Watson, A., Dias, A., Subhani, J., Harvey, R., Mccorry, R., Ramanaden, D., Gasem, J., Evans, R., Mathialahan, T., Shorrock, C., Lipscomb, G., Southern, P., Tibble, J., Gorard, D., Palegwala, A., Jones, S., Dawwas, M., Alexander, G., Dolwani, S., Prince, M., Foxton, M., Elphick, D., Mitchison, H., Gooding, I., Karmo, M., Saksena, S., Mendall, M., Patel, M., Ede, R., Austin, A., Sayer, J., Hankey, L., Hovell, C., Fisher, N., Carter, M., Koss, K., Piotrowicz, A., Grimley, C., Neal, D., Lim, G., Levi, S., Ala, A., Broad, A., Saeed, A., Wood, G., Brown, J., Wilkinson, M., Gordon, H., Ramage, J., Ridpath, J., Ngatchu, T., Grover, B., Shaukat, S., Shidrawi, R., Abouda, G., Ali, F., Rees, I., Salam, I., Narain, M., Brown, A., Taylor-Robinson, S., Williams, S., Grellier, L., Banim, P., Das, D., Chilton, A., Heneghan, M., Curtis, H., Gess, M., Drake, I., Aldersley, M., Davies, M., Jones, R., Mcnair, A., Srirajaskanthan, R., Pitcher, M., Sen, S., Bird, G., Barnardo, A., Kitchen, P., Yoong, K., Chirag, O., Sivaramakrishnan, N., Macfaul, G., Jones, D., Shah, A., Evans, C., Saha, S., Pollock, K., Bramley, P., Mukhopadhya, A., Fraser, A., Mills, P., Shallcross, C., Campbell, S., Bathgate, A., Shepherd, A., Dillon, J., Rushbrook, S., Przemioslo, R., Macdonald, C., Metcalf, J., Shmueli, U., Davis, A., Naqvi, A., Lee, T., Ryder, S. D., Collier, J., Klass, H., Ninkovic, M., Cramp, M., Sharer, N., Aspinall, R., Goggin, P., Ghosh, D., Douds, A., Hoeroldt, B., Booth, J., Williams, E., Hussaini, H., Stableforth, W., Ayres, R., Thorburn, D., Marshall, E., Burroughs, A., Mann, S., Lombard, M., Richardson, P., Patanwala, I., Maltby, J., Brookes, M., Mathew, R., Vyas, S., Singhal, S., Gleeson, D., Misra, S., Butterworth, J., George, K., Harding, T., Douglass, A., Panter, S., Shearman, J., Bray, G., Butcher, G., Forton, D., Mclindon, J., Cowan, M., Whatley, G., Mandal, A., Gupta, H., Sanghi, P., Jain, S., Pereira, S., Prasad, G., Watts, G., Wright, M., Neuberger, J., Gordon, F., Unitt, E., Grant, A., Delahooke, T., Higham, A., Brind, A., Cox, M., Ramakrishnan, S., King, A., Collins, C., Whalley, S., Li, A., Fraser, J., Bell, A., Wong, V. S., Singhal, A., Gee, I., Ang, Y., Ransford, R., Gotto, J., Millson, C., Bowles, J., Thomas, C., Harrison, M., Galaska, R., Kendall, J., Whiteman, J., Lawlor, C., Gray, C., Elliott, K., Mulvaney-Jones, C., Hobson, L., Van Duyvenvoorde, G., Loftus, A., Seward, K., Penn, R., Maiden, J., Damant, R., Hails, J., Cloudsdale, R., Silvestre, V., Glenn, S., Dungca, E., Wheatley, N., Doyle, H., Kent, M., Hamilton, C., Braim, D., Wooldridge, H., Abrahams, R., Paton, A., Lancaster, N., Gibbins, A., Hogben, K., Desousa, P., Muscariu, F., Musselwhite, J., Mckay, A., Tan, L., Foale, C., Brighton, J., Flahive, K., Nambela, E., Townshend, P., Ford, C., Holder, S., Palmer, C., Featherstone, J., Nasseri, M., Sadeghian, J., Williams, B., Rolls, S. -A., Hynes, A., Duggan, C., Crossey, M., Stansfield, G., Macnicol, C., Wilkins, J., Wilhelmsen, E., Raymode, P., Lee, H. -J., Durant, E., Bishop, R., Ncube, N., Tripoli, S., Casey, R., Cowley, C., Miller, R., Houghton, K., Ducker, S., Wright, F., Bird, B., Baxter, G., Keggans, J., Hughes, M., Grieve, E., Young, K., Williams, D., Ocker, K., Hines, F., Martin, K., Innes, C., Valliani, T., Fairlamb, H., Thornthwaite, S., Eastick, A., Tanqueray, E., Morrison, J., Holbrook, B., Browning, J., Walker, K., Congreave, S., Verheyden, J., Slininger, S., Stafford, L., O'Donnell, D., Ainsworth, M., Lord, S., Kent, L., March, L., Dickson, C., Simpson, D., Longhurst, B., Hayes, M., Shpuza, E., White, N., Besley, S., Pearson, S., Wright, A., Jones, L., Gunter, E., Dewhurst, H., Fouracres, A., Farrington, L., Graves, L., Marriott, S., Leoni, M., Tyrer, D., Dali-kemmery, L., Lambourne, V., Green, M., Sirdefield, D., Amor, K., Colley, J., Shinder, B., Jones, J., Mills, M., Carnahan, M., Taylor, N., Boulton, K., Tregonning, J., Brown, C., Clifford, G., Archer, E., Hamilton, M., Curtis, J., Shewan, T., Walsh, S., Warner, K., Netherton, K., Mupudzi, M., Gunson, B., Gitahi, J., Gocher, D., Batham, S., Pateman, H., Desmennu, S., Conder, J., Clement, D., Gallagher, S., Orpe, J., Chan, P., Currie, L., O'Donohoe, L., Oblak, M., Morgan, L., Quinn, M., Amey, I., Baird, Y., Cotterill, D., Cumlat, L., Winter, L., Greer, S., Spurdle, K., Allison, J., Dyer, S., Sweeting, H., Kordula, J., Aiba, Y., Nakamura, H., Abiru, S., Nagaoka, S., Komori, A., Yatsuhashi, H., Ishibashi, H., Ito, M., Kawai, Y., Kohn, S. -S., Gervais, O., Migita, K., Katsushima, S., Naganuma, A., Sugi, K., Komatsu, T., Mannami, T., Matsushita, K., Yoshizawa, K., Makita, F., Nikami, T., Nishimura, H., Kouno, H., Ota, H., Komura, T., Nakamura, Y., Shimada, M., Hirashima, N., Komeda, T., Ario, K., Nakamuta, M., Yamashita, T., Furuta, K., Kikuchi, M., Naeshiro, N., Takahashi, H., Mano, Y., Tsunematsu, S., Yabuuchi, I., Shimada, Y., Yamauchi, K., Sugimoto, R., Sakai, H., Mita, E., Koda, M., Tsuruta, S., Kamitsukasa, H., Sato, T., Masaki, N., Kobata, T., Fukushima, N., Higuchi, N., Ohara, Y., Muro, T., Takesaki, E., Takaki, H., Yamamoto, T., Kato, M., Nagaoki, Y., Hayashi, S., Ishida, J., Watanabe, Y., Kobayashi, M., Koga, M., Saoshiro, T., Yagura, M., Hirata, K., Takikawa, H., Ohira, H., Zeniya, M., Abe, M., Onji, M., Kaneko, S., Honda, M., Arai, K., Arinaga-Hino, T., Hashimoto, E., Taniai, M., Umemura, T., Joshita, S., Nakao, K., Ichikawa, T., Shibata, H., Yamagiwa, S., Seike, M., Honda, K., Sakisaka, S., Takeyama, Y., Harada, M., Senju, M., Yokosuka, O., Kanda, T., Ueno, Y., Kikuchi, K., Ebinuma, H., Himoto, T., Yasunami, M., Murata, K., Mizokami, M., Shimoda, S., Miyake, Y., Takaki, A., Yamamoto, K., Hirano, K., Ichida, T., Ido, A., Tsubouchi, H., Chayama, K., Harada, K., Nakanuma, Y., Maehara, Y., Taketomi, A., Shirabe, K., Soejima, Y., Mori, A., Yagi, S., Uemoto, S., Tanaka, T., Yamashiki, N., Tamura, S., Sugawara, Y., Kokudo, N., Carbone, M., Cardamone, G., Duga, S., Gershwin, M. E., Seldin, M. F., Invernizzi, P., Asselta R., Paraboschi E.M., Gerussi A., Cordell H.J., Mells G.F., Sandford R.N., Jones D.E., Nakamura M., Ueno K., Hitomi Y., Kawashima M., Nishida N., Tokunaga K., Nagasaki M., Tanaka A., Tang R., Li Z., Shi Y., Liu X., Xiong M., Hirschfield G., Siminovitch K.A., Walker E., Xie G., Mason A., Myers R., Peltekian K., Ghent C., Atkinson E., Juran B., Lazaridis K., Lu Y., Gu X., Jing K., Amos C., Affronti A., Brunetto M., Coco B., Spinzi G., Elia G., Ferrari C., Lleo A., Muratori L., Muratori P., Portincasa P., Colli A., Bruno S., Colloredo G., Azzaroli F., Andreone P., Bragazzi M., Alvaro D., Cardinale V., Cazzagon N., Rigamonti C., Floreani A., Rosina F., Ciaccio A., Cristoferi L., D'Amato D., Malinverno F., Mancuso C., Massironi S., Milani C., O'Donnell S.E., Ronca V., Barisani D., Lampertico P., Donato F., Fagiuoli S., Almasio P.L., Giannini E., Cursaro C., Colombo M., Valenti L., Miele L., Andriulli A., Niro G.A., Grattagliano I., Morini L., Casella G., Vinci M., Battezzati P.M., Crosignani A., Zuin M., Mattalia A., Calvaruso V., Colombo S., Benedetti A., Marzioni M., Galli A., Marra F., Tarocchi M., Picciotto A., Morisco F., Fabris L., Croce L.S., Tiribelli C., Toniutto P., Strazzabosco M., Ch'ng C.L., Rahman M., Yapp T., Sturgess R., Healey C., Czajkowski M., Gunasekera A., Gyawali P., Premchand P., Kapur K., Marley R., Foster G., Watson A., Dias A., Subhani J., Harvey R., McCorry R., Ramanaden D., Gasem J., Evans R., Mathialahan T., Shorrock C., Lipscomb G., Southern P., Tibble J., Gorard D., Palegwala A., Jones S., Dawwas M., Alexander G., Dolwani S., Prince M., Foxton M., Elphick D., Mitchison H., Gooding I., Karmo M., Saksena S., Mendall M., Patel M., Ede R., Austin A., Sayer J., Hankey L., Hovell C., Fisher N., Carter M., Koss K., Piotrowicz A., Grimley C., Neal D., Lim G., Levi S., Ala A., Broad A., Saeed A., Wood G., Brown J., Wilkinson M., Gordon H., Ramage J., Ridpath J., Ngatchu T., Grover B., Shaukat S., Shidrawi R., Abouda G., Ali F., Rees I., Salam I., Narain M., Brown A., Taylor-Robinson S., Williams S., Grellier L., Banim P., Das D., Chilton A., Heneghan M., Curtis H., Gess M., Drake I., Aldersley M., Davies M., Jones R., McNair A., Srirajaskanthan R., Pitcher M., Sen S., Bird G., Barnardo A., Kitchen P., Yoong K., Chirag O., Sivaramakrishnan N., MacFaul G., Jones D., Shah A., Evans C., Saha S., Pollock K., Bramley P., Mukhopadhya A., Fraser A., Mills P., Shallcross C., Campbell S., Bathgate A., Shepherd A., Dillon J., Rushbrook S., Przemioslo R., Macdonald C., Metcalf J., Shmueli U., Davis A., Naqvi A., Lee T., Ryder S.D., Collier J., Klass H., Ninkovic M., Cramp M., Sharer N., Aspinall R., Goggin P., Ghosh D., Douds A., Hoeroldt B., Booth J., Williams E., Hussaini H., Stableforth W., Ayres R., Thorburn D., Marshall E., Burroughs A., Mann S., Lombard M., Richardson P., Patanwala I., Maltby J., Brookes M., Mathew R., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Panter S., Shearman J., Bray G., Butcher G., Forton D., Mclindon J., Cowan M., Whatley G., Mandal A., Gupta H., Sanghi P., Jain S., Pereira S., Prasad G., Watts G., Wright M., Neuberger J., Gordon F., Unitt E., Grant A., Delahooke T., Higham A., Brind A., Cox M., Ramakrishnan S., King A., Collins C., Whalley S., Li A., Fraser J., Bell A., Wong V.S., Singhal A., Gee I., Ang Y., Ransford R., Gotto J., Millson C., Bowles J., Thomas C., Harrison M., Galaska R., Kendall J., Whiteman J., Lawlor C., Gray C., Elliott K., Mulvaney-Jones C., Hobson L., Van Duyvenvoorde G., Loftus A., Seward K., Penn R., Maiden J., Damant R., Hails J., Cloudsdale R., Silvestre V., Glenn S., Dungca E., Wheatley N., Doyle H., Kent M., Hamilton C., Braim D., Wooldridge H., Abrahams R., Paton A., Lancaster N., Gibbins A., Hogben K., Desousa P., Muscariu F., Musselwhite J., McKay A., Tan L., Foale C., Brighton J., Flahive K., Nambela E., Townshend P., Ford C., Holder S., Palmer C., Featherstone J., Nasseri M., Sadeghian J., Williams B., Rolls S.-A., Hynes A., Duggan C., Crossey M., Stansfield G., MacNicol C., Wilkins J., Wilhelmsen E., Raymode P., Lee H.-J., Durant E., Bishop R., Ncube N., Tripoli S., Casey R., Cowley C., Miller R., Houghton K., Ducker S., Wright F., Bird B., Baxter G., Keggans J., Hughes M., Grieve E., Young K., Williams D., Ocker K., Hines F., Martin K., Innes C., Valliani T., Fairlamb H., Thornthwaite S., Eastick A., Tanqueray E., Morrison J., Holbrook B., Browning J., Walker K., Congreave S., Verheyden J., Slininger S., Stafford L., O'Donnell D., Ainsworth M., Lord S., Kent L., March L., Dickson C., Simpson D., Longhurst B., Hayes M., Shpuza E., White N., Besley S., Pearson S., Wright A., Jones L., Gunter E., Dewhurst H., Fouracres A., Farrington L., Graves L., Marriott S., Leoni M., Tyrer D., Dali-kemmery L., Lambourne V., Green M., Sirdefield D., Amor K., Colley J., Shinder B., Jones J., Mills M., Carnahan M., Taylor N., Boulton K., Tregonning J., Brown C., Clifford G., Archer E., Hamilton M., Curtis J., Shewan T., Walsh S., Warner K., Netherton K., Mupudzi M., Gunson B., Gitahi J., Gocher D., Batham S., Pateman H., Desmennu S., Conder J., Clement D., Gallagher S., Orpe J., Chan P., Currie L., O'Donohoe L., Oblak M., Morgan L., Quinn M., Amey I., Baird Y., Cotterill D., Cumlat L., Winter L., Greer S., Spurdle K., Allison J., Dyer S., Sweeting H., Kordula J., Aiba Y., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Kawai Y., Kohn S.-S., Gervais O., Migita K., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Higuchi N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Takikawa H., Ohira H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Carbone M., Cardamone G., Duga S., Gershwin M.E., Seldin M.F., Invernizzi P., Asselta, R, Paraboschi, E, Gerussi, A, Cordell, H, Mells, G, Sandford, R, Jones, D, Nakamura, M, Ueno, K, Hitomi, Y, Kawashima, M, Nishida, N, Tokunaga, K, Nagasaki, M, Tanaka, A, Tang, R, Li, Z, Shi, Y, Liu, X, Xiong, M, Hirschfield, G, Siminovitch, K, Walker, E, Xie, G, Mason, A, Myers, R, Peltekian, K, Ghent, C, Atkinson, E, Juran, B, Lazaridis, K, Lu, Y, Gu, X, Jing, K, Amos, C, Affronti, A, Brunetto, M, Coco, B, Spinzi, G, Elia, G, Ferrari, C, Lleo, A, Muratori, L, Muratori, P, Portincasa, P, Colli, A, Bruno, S, Colloredo, G, Azzaroli, F, Andreone, P, Bragazzi, M, Alvaro, D, Cardinale, V, Cazzagon, N, Rigamonti, C, Floreani, A, Rosina, F, Ciaccio, A, Cristoferi, L, D'Amato, D, Malinverno, F, Mancuso, C, Massironi, S, Milani, C, O'Donnell, S, Ronca, V, Barisani, D, Lampertico, P, Donato, F, Fagiuoli, S, Almasio, P, Giannini, E, Cursaro, C, Colombo, M, Valenti, L, Miele, L, Andriulli, A, Niro, G, Grattagliano, I, Morini, L, Casella, G, Vinci, M, Battezzati, P, Crosignani, A, Zuin, M, Mattalia, A, Calvaruso, V, Colombo, S, Benedetti, A, Marzioni, M, Galli, A, Marra, F, Tarocchi, M, Picciotto, A, Morisco, F, Fabris, L, Croce, L, Tiribelli, C, Toniutto, P, Strazzabosco, M, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Dawwas, M, Alexander, G, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Taylor-Robinson, S, Williams, S, Grellier, L, Banim, P, Das, D, Chilton, A, Heneghan, M, Curtis, H, Gess, M, Drake, I, Aldersley, M, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Bathgate, A, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Thorburn, D, Marshall, E, Burroughs, A, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Neuberger, J, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney-Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Williams, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, O'Donnell, D, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali-kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, O'Donohoe, L, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, Kordula, J, Aiba, Y, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Kawai, Y, Kohn, S, Gervais, O, Migita, K, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Higuchi, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Takikawa, H, Ohira, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Carbone, M, Cardamone, G, Duga, S, Gershwin, M, Seldin, M, Invernizzi, P, Asselta R, Paraboschi EM, Gerussi A, Cordell HJ, Mells GF, Sandford RN, Jones DE, Nakamura M, Ueno K, Hitomi Y, Kawashima M, Nishida N, Tokunaga K, Nagasaki M, Tanaka A, Tang R, Li Z, Shi Y, Liu X, Xiong M, Hirschfield G, Siminovitch KA, Canadian-US PBC Consortium, Italian PBC Genetics Study Group, UK-PBC Consortium, Japan PBC-GWAS Consortium, Carbone M, Cardamone G, Duga S, Gershwin ME, Seldin MF, Invernizzi P, and LiveR North

Subjects
Canadian-US PBC Consortium, 0301 basic medicine, Male, Linkage disequilibrium, Genome-wide association study, Disease, PBC, Settore MED/03 - GENETICA MEDICA, Linkage Disequilibrium, 0302 clinical medicine, UK-PBC Consortium, Genotype, Mitochondrial Precursor Protein Import Complex Proteins, Italian PBC Genetics Study Group, Odds Ratio, X-Wide Association Study, Japan PBC-GWAS Consortium, X chromosome, Genetics, Liver Cirrhosis, Biliary, Gastroenterology, Forkhead Transcription Factors, DNA-Binding Proteins, Shal Potassium Channels, 030211 gastroenterology & hepatology, Female, Adult, Monosaccharide Transport Proteins, Superenhancer, Locus (genetics), Single-nucleotide polymorphism, Biology, Protein Serine-Threonine Kinases, Polymorphism, Single Nucleotide, Article, White People, 03 medical and health sciences, Asian People, Proto-Oncogene Proteins, Endopeptidases, Humans, Cell Lineage, Genetic Predisposition to Disease, Meta-analysi, Genetic association, Chromosomes, Human, X, Gastroenterology & Hepatology, Hepatology, 1103 Clinical Sciences, Meta-analysis, 030104 developmental biology, Genetic Loci, 1114 Paediatrics and Reproductive Medicine, 1109 Neurosciences, Carrier Proteins, Genome-Wide Association Study
Abstract

Background & aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10-4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10-6; odds ratio [OR], 1.39; 95% confidence interval [CI], 1.028-1.88; Japanese cohort). Although the transethnic meta-analysis evidenced only a suggestive signal (rs2239452, mapping within the PIM2 gene; OR, 1.17; 95% CI, 1.09-1.26; P = 9.93 × 10-8), the population-specific meta-analysis showed a genome-wide significant locus in East Asian individuals pointing to the same region (rs7059064, mapping within the GRIPAP1 gene; P = 6.2 × 10-9; OR, 1.33; 95% CI, 1.21-1.46). Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP3, the main T-regulatory cell lineage specification factor. Consistently, OTUD5 and FOXP3 RNA levels were up-regulated in PBC case patients (1.75- and 1.64-fold, respectively). Conclusions: This work represents the first comprehensive study, to our knowledge, of the chrX contribution to the genetics of an autoimmune liver disease and shows a novel PBC-related genome-wide significant locus.

Published
2021

4. Hydrogen permeation and recombination in Ni membrane placed on spherical tokamak QUEST

Author

T. Komura, Yuji Hatano, Y. Nakamura, S.K. Sharma, Akio Sagara, Y. Hisano, R. Imade, Ikuji Takagi, Hideki Zushi, and N. Ashikawa

Subjects
Nuclear and High Energy Physics, Tokamak, Hydrogen, Chemistry, Analytical chemistry, chemistry.chemical_element, Plasma, Atmospheric temperature range, Permeation, Spherical tokamak, Thermal diffusivity, law.invention, Membrane, Nuclear Energy and Engineering, law, General Materials Science
Abstract

A permeation measuring system with a nickel membrane of 30 μm thickness was installed in a spherical tokamak QUEST. The membrane was located near the mid plane of the tokamak so that one side of the membrane was faced to the plasma. After the membrane was heated to 502 K, hydrogen plasma was discharged using 2.45 GHz RF system. The permeation flux through the membrane increased with a proper time-lag, that is, a significant plasma-driven permeation was observed. A numerical calculation of the diffusion equation under recombination boundary conditions was successfully conducted to simulate the transient permeation behavior. The recombination coefficients, estimated in a temperature range of 412–575 K, can be explained by a model of thermally activated processes. Stable operation of the permeation system indicates the suitability of this system for the measurements of atomic flux with known diffusivity and recombination coefficients.

Published
2011
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5. Diabetes (PP-104)

Author

Katharine M. Irvine, A. Yasukawa, L. Steidler, M. Roncarolo, J. Hofmann, B. Xu, A. G. Baxter, H. Dooms, S. Han, D. P. Funda, Andrew Cotterill, H. K. Takahashi, H. Kawakami, C. J. M. Saris, M. Nishibori, A. M. Cotterill, S. Watanabe, K. S. Shtayn, Y. Lim, T. Chikovani, I. Yermak, S. Moon, J. Kwon, H. Sytwu, T. Abufazeli, K. Sugimura, G. A. S. Passos, T. Hegay, W. Kuswanto, A. E. Feijó, H. F. Carvalho, M. Ogata, Christine A. Wells, K. Hwang, T. Takiishi, N. Ide-Iwata, K. Tauchi, S. Chen, Z. Yang, M. Lin, Y. Huang, S. Oazaki, A. Enomoto, M. Vojgani, L. Zhang, R. Cook, A. Y. Ramirez Marmol, T. Fujikawa, L. C. Harrison, D. Pang, K. Node, V. Ordodi, H. Fujimoto, K. Yoshida, D. Boveda Ruiz, T. Takagi, P. Maffi, S. Yekollu, L. Teyton, A. P. M. Fernandes, S. Chowdhury, P. Gil Bernabe, L. Grice, K. Huszarik, M. Cristea, F. A. Mic, N. Gerlach, Y. Nishitani, H. Kozakova, B. Singh, E. Sokolova, J. A. Bluestone, M. C. Foss-Freitas, H. Matsumoto, K. Rekhviashvili, A. Valle, A. Kretowski, E. Ramos, J. W. Herzog, A. Ishizaka, C. Gysemans, M. L. Lukić, S. Shieh, N. Deghaide, Y. Miyake, É. Szabó, P. Monti, T. Takamura, Y. Sakai, S. J. Petzold, J. O. Crispim, E. Oh, S. M. Pavlović, R. Katada, S. Sherwani, A. Nishimoto-Hazuku, P. Fundova, Y. Miyazaki, O. L. Schuklina, T. Decsi, Thomas W.H. Kay, L. Piemonti, T. Won, S. Bertin-Maghit, J. Wands, Gethin P. Thomas, R. Bogdanovich, C. Ortiz-Martínez, E. R. Unanue, N. N. Arsenijević, L. Harrison, S. Olek, F. Chou, A. Nikolaeva, J. F. Mohan, E. C. Gabazza, A. Bossowski, Ranjeny Thomas, F. M. Bojin, Z. Xu, S. Smith, Raymond J. Steptoe, Patricia H. Gallego, R. Jose, B. F. Lin, H. Kong, V. A. Lopatina, M. Chibana, K. Cho, C. Staudacher, B. Jabri, P. Rottiers, A. Rosca, R. O'Brien, M. Toda, A. Chavarria, T. Y. Lu, E. N. Smirnova, J. Morser, C. M. Junta, M. W. A. Khan, C. A. Tatu, S. Green Mitchell, Y. Lee, J. L. Nadler, K. Aydintug, S. Kaneko, M. A. Morris, L. A. Peroni, V. M. Timganova, N. Kikodze, M. Chien, K. Fujii, H. Oh, D. Chang, E. A. Donadi, D. Lee, A. Secchi, B. Melo-Lima, T. Marosvölgyi, M. Tomoyoshi, I. A. Wilson, A. Stasiak-Barmuta, N. Jin, J. Kos, W. Park, R. Ruscher, A. Ferraro, C. Socci, T. Takeuchi, K. Matsushima, S. Shin, A. K. Abbas, M. Tanaka, N. Wawrusiewicz-Kurylonek, W. Luczynski, S. Dervish, A. Stabilini, H. Yoshida, M. C. Foss, S. Ookuma, Mark Harris, C. J. Jackson, A. L. Corper, M. G. Levisetti, Y. Wang, K. Mizuo, T. Baskerville, Helen E. Thomas, I. Pantsulaia, W. Born, Matthew A. Brown, M. Scavini, S. Mori, H. Namdari, B. Calderon, Y. Park, J. Bang, M. Taherian, C. Penaranda, K. Liu, T. Aripova, Y. Yano, K. Tateda, T. Aboofazeli, C. Mathieu, L. Yeh, H. Hara, S. Roffler, Emily Duggan, E. T. Sakamoto-Hojo, C. N. D'Alessandro-Gabazza, D. M. Rassi, P. Yu, E. Ilendo, T. Komura, T. Hirase, V. Paunescu, S. Michie, J. Roddick, G. Eisenbarth, R. Pérez-Tamayo, D. R. Stach-Machado, E. M. Kuklina, K. Otsu, I. J. Wastowski, S. Kryzhanovskiy, S. Flynn, O. I. Gavriliuc, A. Tárnok, S. Kim, N. S. Zdravković, G. Fulcher, R. Nano, Saparna Pai, W. Lin, G. Martelli-Palomino, M. Honda, E. Salehi, M. Battaglia, O. L. Gorbunova, K. Kim, M. Iobadze, M. Xue, M. Ghayedi, Brendan O'Sullivan, J. A. F. da Silva, S. Best, H. Wake, K. Zufarova, D. Song, H. Pahao, H. Tlaskalova-Hogenova, J. Shin, O. Taguchi, K. Buschard, E. Bonifacio, G. Lin, K. Takahashi, M. Lai, M. Gorska, and S. Okazaki

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Diabetes mellitus, Immunology, medicine, Immunology and Allergy, General Medicine, medicine.disease, business
Published
2010
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6. Preparation of micrometer-sized, monodisperse, magnetic polymer particles

Author

Masayoshi Okubo, T. Komura, and Hideto Minami

Subjects
Dispersion polymerization, Materials science, Polymers and Plastics, Dispersity, Radical polymerization, General Chemistry, Surfaces, Coatings and Films, Micrometre, Colloid, chemistry.chemical_compound, Polymerization, chemistry, Chemical engineering, Polymer chemistry, Materials Chemistry, Polystyrene, Microparticle
Abstract

Micrometer-sized, monodisperse, magnetic composite particles were prepared by heating micrometer-sized, monodisperse, hollow polystyrene/polydivinylbenzene composite polymer particles at 200°C for 4 h (particles had been dipped in pentacarbonyliron) and then washed in 12 N HCl and water. The hollow polymer particles were produced by seeded polymerization by the dynamic swelling method that was proposed by authors. The magnetic composite particles contained Fe3O4, the content of which was 49% based on total weight, and were attracted easily in water by a 1650 G magnet. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 88: 428–433, 2003

Published
2003
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8. X-ray Study of CHF3 and CH3Cl Monolayers on Boron Nitride

Author

Kunimitsu Morishige and T. Komura

Subjects
Diffraction, Chemistry, Stereochemistry, X-ray, Surfaces and Interfaces, Halocarbon, Condensed Matter Physics, chemistry.chemical_compound, Crystallography, Adsorption, Boron nitride, X-ray crystallography, Monolayer, Electrochemistry, General Materials Science, Basal plane, Spectroscopy
Abstract

The structures of CHF3 and CH3Cl monolayers adsorbed on the basal plane of boron nitride have been examined by X-ray diffraction. For CHF3, orientationally disordered, triangular, incommensurate hi...

Published
1998
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10. Soft Magnetic Properties and Corrosion Resistance of Nanocrystalline Fe-Al-Ta-C Films

Author

F. Koike, Toshiro Sato, T. Komura, M. Saito, and T. Watanabe

Subjects
Materials science, Electrical resistance and conductance, Chemical engineering, Electrical resistivity and conductivity, Annealing (metallurgy), Metallurgy, Optical polarization, Microstructure, Nanocrystalline material, Amorphous solid, Corrosion
Abstract

The effect of addition of Al to sputtered nanocrystalline Fe-Ta-C films on the film structure, soft magnetic properties and corrosion resistance were investigated. Films were crystallized from an amorphous state to a nanocrystalline state in which ultra-fine TaC particles were dispersed. Most of the Al in the films was dissolved in ?-Fe after crystallization. When the Al concentration was increased, the high-frequency permeability improved owing to the increase in electrical resistivity. The thermal stability of the soft magnetic properties was also improved over that of Fe-Ta-C films, and the film corrosion resistance improved sufficiently, probably because of the Al dissolved in ?-Fe. An Fe 66.6 Al 10.6 Ta 10.5 C 12.3 nanocrystalline film after annealing at 823K exhibited a high saturation point of 1.25 T, a high permeability of 3200 at 1 MHz, a high electrical resistivity of 1.32 ??-m, and excellent corrosion resistance and noble pitting potential.

Published
1994
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11. Tooth eruption in a patient with craniometaphyseal dysplasia: case report

Author

Shizuo Sobue, Takashi Ooshima, T. Komura, and Tetsuyuki Hayashibara

Subjects
Orthodontics, Molar, Cancer Research, Hyperostosis, Dentition, business.industry, Tooth eruption, Dentistry, medicine.disease, Osteochondrodysplasia, Pathology and Forensic Medicine, stomatognathic diseases, stomatognathic system, Otorhinolaryngology, Maxilla, medicine, Periodontics, Oral Surgery, Malocclusion, business, Permanent teeth
Abstract

Craniometaphyseal dysplasia (CMD) is a very rare genetic disorder of bone remodeling caused by osteoclast dysfunction. The clinical and radiographical features of oral findings are presented in a sporadic case of CMD in a child (age 10 years, 7 months). An intraoral examination showed severe malocclusions, including anterior crossbite and deep bite. Furthermore, a radiographic examination showed increased radiopacity of the maxilla and mandibular bones due to hyperostosis and sclerosis of the jaw. There was no root resorption of the canines or molars in the primary dentition, although root formation of the permanent teeth was proceeding. Dental age was calculated to be approximately 1 year, 4 months younger than his chronological age. The eruption speed of the permanent lateral incisors after the gingival emergence was shown to be within normal values, and we discuss whether the canines and premolars in the permanent dentition could erupt or not.

Published
2000
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12. P2H-5 Small 3x2.5mm² Sized Surface Acoustic Wave Duplexer for US-PCS with Excellent Temperature and Frequency Characteristics

Author

N. Takada, D. Yamamoto, Y. Nakai, Michio Kadota, T. Komura, Y. Ishiura, R. Kita, K. Nishiyama, and Takeshi Nakao

Subjects
Bonding process, Materials science, business.industry, Surface acoustic wave, Substrate (electronics), Piezoelectricity, symbols.namesake, Duplexer, Electrode, symbols, Optoelectronics, Rayleigh scattering, Telecommunications, business, Temperature coefficient
Abstract

Using flattened-SiO2/Cu-electrode/36~48deg LiTaO3 structure, small size (5 x5mm2) surface acoustic wave (SAW) duplexer with a good temperature coefficient of frequency (TCF) for US-PCS was realized by authors. However, a smaller duplexer has been strongly required. Using flip-chip bonding process of SAW chips and Rayleigh SAW propagating on the flattened-SiO2/Cu- electrode/126~128degYX-LiNbO3, which has larger cou pling factor than above-mentioned substrate, a smaller sized (3x2.5mm2) SAW duplexer with a good TCF has been realized.

Published
2007
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13. SAW substrate with coupling factor and excellent temperature stability suitable for duplexer of PCS in US

Author

Michio Kadota, K. Nishiyama, Norio Taniguchi, Takeshi Nakao, Eiichi Takata, Takuo Hada, T. Komura, and Masakazu Mimura

Subjects
Coupling, Electromechanical coupling coefficient, Materials science, business.industry, Acoustics, Surface acoustic wave, Substrate (electronics), Transition band, symbols.namesake, Duplexer, symbols, Optoelectronics, Reflection coefficient, Rayleigh wave, business
Abstract

The pass-bands of a transmission (Tx) and a receiving (Rx) of the Personal Communication Services (PCS) Handy-phone in US are 1850-1910 MHz and 1930-1990 MHz, respectively. The transition bandwidth between the Tx and the Rx is very narrow as 20 MHz compared with other systems. A duplexer for the PCS using surface acoustic wave (SAW) requires a SAW substrate, which has a the good temperature stability, an optimum electromechanical coupling factor, and a large reflection coefficient. Some Rayleigh waves and leaky SAW (LSAW) on various substrate or structures have a good temperature characteristic, but almost all of them have not an optimum coupling factor and a large reflection coefficient for the US-PCS duplexer. In 2003, the authors reported a US-PCS SAW duplexer having good temperature stability, a steep frequency characteristic in transition band, a low loss, and a large out-of-band suppression. This paper describes the detail of the new substrate having the good temperature stability, the optimum electromechanical coupling factor, and sufficient reflection coefficient.

Published
2005
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15. SAW duplexer for PCS in US with excellent temperature stability

Author

E. Takata, Takeshi Nakao, N. Taniguchi, Masakazu Mimura, T. Hada, Michio Kadota, K. Nishiyama, and T. Komura

Subjects
Resonator, Materials science, Transmission (telecommunications), Duplexer, Frequency band, Acoustics, Bandwidth (signal processing), Surface acoustic wave, Transition band, Antenna (radio)
Abstract

The transition frequency band between Tx (transmission) and Rx (receiving) pass bands of the personal communication services (PCS) handy phone in US is relatively narrow (20MHz) compared with similar systems' handy phones. The antenna duplexer for the PCS needs a good temperature stability of frequency and a steep cut-off frequency characteristics in the transition band. Up to the present, there exists no substrate for the surface acoustic wave (SAW) having both the good temperature stability and the optimum electromechanical coupling factor to realize the required bandwidth of the PCS duplexer. So, the PCS SAW duplexer has been developed with the only steeper cut-off characteristics to eke out its insufficient temperature stability. The PCS duplexers consisting of FBAR (film bulk acoustic resonator) have also been designed as another approach, but their temperature characteristics are not enough. This paper describes a new substrate having both the good temperature stability and the suitable electromechanical coupling factor and a US-PCS SAW duplexer constructed of this substrate.

Published
2004
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16. Tooth eruption in a patient with craniometaphyseal dysplasia: case report

Author

T, Hayashibara, T, Komura, S, Sobue, and T, Ooshima

Subjects
Craniofacial Abnormalities, Male, Sclerosis, Root Resorption, Humans, Hyperostosis, Tooth Exfoliation, Child, Jaw Diseases, Malocclusion, Tooth Eruption
Abstract

Craniometaphyseal dysplasia (CMD) is a very rare genetic disorder of bone remodeling caused by osteoclast dysfunction. The clinical and radiographical features of oral findings are presented in a sporadic case of CMD in a child (age 10 years, 7 months). An intraoral examination showed severe malocclusions, including anterior crossbite and deep bite. Furthermore, a radiographic examination showed increased radiopacity of the maxilla and mandibular bones due to hyperostosis and sclerosis of the jaw. There was no root resorption of the canines or molars in the primary dentition, although root formation of the permanent teeth was proceeding. Dental age was calculated to be approximately 1 year, 4 months younger than his chronological age. The eruption speed of the permanent lateral incisors after the gingival emergence was shown to be within normal values, and we discuss whether the canines and premolars in the permanent dentition could erupt or not.

Published
2000

18. [Advanced prostate cancer with normal serum prostate-specific antigen values]

Author

T, Komura, K, Yamagiwa, H, Ogura, Y, Kohjimoto, T, Ohkawa, T, Inagaki, S, Ebisuno, and A, Senzaki

Subjects
Aged, 80 and over, Male, Prostatectomy, Reference Values, Biomarkers, Tumor, Humans, Prostatic Neoplasms, Adenocarcinoma, Middle Aged, Prostate-Specific Antigen, Aged
Abstract

Although prostate-specific antigen (PSA) is a valuable marker of prostate cancer, some untreated patients with advanced prostate cancer have normal PSA values. Over a period of 5 years, we reviewed pretreatment serum PSA levels in 131 patients with advanced prostate cancer (stages C and D). Ten patients (7.6%) had normal PSA values. The histological type of prostate cancer associated with normal PSA values was variable and the prognosis was not so poor. Immunostaining for PSA was performed on the resected prostate tissue of the 10 patients. PSA staining was positive in 5 cases, negative in 3 cases, and equivocal in the remaining 2 cases. In conclusion, PSA is not always useful, especially for following patients with normal PSA values.

Published
1998

19. [Retropharyngeal node metastasis in cancer of the oropharynx and hypopharynx: analysis of retropharyngeal node dissection regarding preoperative radiographic diagnosis]

Author

Yasuhisa Hasegawa, Bin Nakayama, Akihiro Terada, Tetsuya Ogawa, Takashi Matsuzuka, Hidehiro Matsuura, T Komura, Koji Okumura, and Yasushi Fujimoto

Subjects
Adult, Male, medicine.medical_specialty, Radiography, medicine.medical_treatment, Oropharynx, Sensitivity and Specificity, Metastasis, medicine, Carcinoma, Humans, Aged, medicine.diagnostic_test, business.industry, Cancer, Magnetic resonance imaging, Neck dissection, Pharyngeal Neoplasms, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Dissection, Hypopharynx, Pharyngeal Neoplasm, Otorhinolaryngology, Lymphatic Metastasis, Carcinoma, Squamous Cell, Lymph Node Excision, Female, Radiology, business, Tomography, X-Ray Computed
Abstract

In our department, all patients with advanced carcinoma of the oropharynx and hypopharynx are treated by retropharyngeal (RP) node dissection in addition to primary resection and standard neck dissection. Records of 42 patients (11 oropharynx, 29 hypopharynx and 2 retromandibula) who received RP node dissection from 1992 to 1996 in our department were examined for metastasis to RP nodes and for preoperative radiographic diagnosis (MRI or CT). The criteria for radiographic involvement of RP nodes are as follows: a diameter greater than 10mm on axial images or central necrosis within the nodal substance. Of the 42 patients, 6 (14.3%) had pathologically positive RP nodes and of those 6 patients, 5 were able to be diagnosed preoperatively by either CT scan or MRI. Results of radiographic diagnosis (MRI or CT) were as follows: by CT scan the sensitivity, specificity and accuracy were all 100% and by MRI the sensitivity, specificity and accuracy were 83.3%, 100% and 97.0% respectively. It is our conclusion that preoperative radiographic diagnosis (MRI or CT) is very useful and effective for diagnosis of metastasis to RP nodes.

Published
1998

20. [Studies on infection urolithiasis--urease induced crystallization in synthetic urine]

Author

T, Komura

Subjects
Nephelometry and Turbidimetry, Humans, Calcium, Magnesium, Urinary Calculi, Urine, Crystallization, Infections, Urease
Abstract

In the present study, urease induced crystallization in synthetic urine was studied by an aggregometer technique.The synthetic urine was made by the method by Griffith et al (1976). The synthetic urine of 200 microliters portions were stirred constantly at 37 degrees C, and then 10 microliters of urease solution (1000 U/ml) was added. An aggregometer were recorded as turbidity curves on a chart during the incubation for the crystallization simultaneously.A two-phase turbidity curve was obtained from the reaction of synthetic urine and urease. Firstly the mild turbidity appeared gradually up until to approximately 13 min, and then the turbidity increased rapidly. The mild turbidity was called "early crystallization" and the rapid turbidity was called "late crystallization". The early crystallization appeared gradually at pH 7.3 and 0.05 M of anmmonia concentration, and this amount was completely depended on the concentration of calcium in the synthetic urine. The late crystallization occurred rapidly at pH 8.5 and 0.06-0.08 M of anmmonia concentration and this amount was completely depended on the concentration of magnesium in the synthetic urine. We confirmed the early crystallization as calcium phosphate and the late crystallization as magnesium ammonium phosphate by the observations of polarized light microscopy as well as the estimations using an infrared spectrometer.Urease induced crystallizations in the synthetic urine had a two-phase turbidity. Firstly the mild turbidity of calcium phosphate appeared gradually, and then rapid turbidity of magnesium ammonium phosphate occurred. Therefore, it is suggested that various crystallizations may be developed in the infected human urine according to the constituents of calcium and magnesium.

Published
1998

21. Effect of LDL-apheresis on the pharmacokinetics of the lipophilic antilipidemic agent probucol

Author

Takahara K, Yasuhide Nakashima, M Sugano, T. Komura, A. Fujinishi, Akio Kuroiwa, and Hiromi Tasaki

Subjects
Male, medicine.medical_specialty, Probucol, Familial hypercholesterolemia, Hyperlipoproteinemia Type II, chemistry.chemical_compound, Pharmacokinetics, Internal medicine, Blood plasma, medicine, Humans, Pharmacology (medical), Pharmacology, Chemistry, Cholesterol, Anticholesteremic Agents, Middle Aged, medicine.disease, Lipids, Lipoproteins, LDL, Endocrinology, LDL apheresis, Blood Component Removal, lipids (amino acids, peptides, and proteins), Female, Antilipidemic Agent, medicine.drug, Lipoprotein
Abstract

The effect of LDL-apheresis on the pharmacokinetics of antilipidemic agents has not been evaluated thoroughly. In this study, we investigated the effect of LDL-apheresis on the pharmacokinetics of probucol, a lipophilic antilipidemic agent, by studying its distribution and changes in the blood concentration of probucol after LDL-apheresis. The concentrations of lipoproteins were measured before and after LDL-apheresis in eight patients with familial hypercholesterolemia taking probucol. Concentrations of probucol in the various lipoprotein fractions and plasma were measured by HPLC. The serum concentrations of probucol before and after LDL-apheresis were 39.8 +/- 3.3 and 16.5 +/- 1.6 micrograms/ml, and the correlation coefficient between the changes in the serum probucol concentration and those in the serum cholesterol concentration before and after LDL-apheresis was significant (r = 0.73, P < 0.01). Changes in the probucol and cholesterol concentrations after LDL-apheresis were mainly found in the LDL fraction. The calculated reductions in the serum contents of probucol and cholesterol were similar to the contents of probucol and cholesterol in the irrigation fluid of the dextran sulfate column. These data suggest that changes of probucol concentration in plasma by LDL-apheresis are mainly due to reductions in the LDL fraction.

Published
1997

22. Characteristics of physical health conditions in middle-aged and elderly joggers

Author

T, Komura, S, Muraki, M, Irizawa, and M, Yamasaki

Subjects
Male, Jogging, Japan, Physical Fitness, Health Status, Humans, Female, Musculoskeletal Diseases, Middle Aged, Aged
Abstract

To clarify the characteristics of physical health conditions in middle-aged and elderly joggers who run regularly, they were compared with middle-aged and elderly people who did not exercise routinely. The physical health conditions were investigated by a questionnaire survey sent by mail. The subjects were 316 joggers (230 men and 86 women) and 272 non-joggers (173 men and 99 women). The number of joggers having any illness was lower than that of non-joggers in both men and women. In contrast, there was no significant difference in type of illness between joggers and non-joggers. Concerning symptoms, the number of joggers who complained of lumbar pain and shoulder stiffness was low, but the number of joggers with symptoms including knee joint pain and muscle pain as well as injury was high compared to non-joggers. While the results of this study reconfirm that continuous jogging in middle-aged and elderly people may effectively improve their physical condition, based on the finding that the morbidity was low, it appears that many joggers have knee joint pain, a typical disorder due to running.

Published
1997

23. Urease-induced crystallizations of calcium phosphate and magnesium ammonium phosphate in synthetic urine and human urine

Author

Shoichi Ebisuno, Tadashi Ohkawa, K. Yamagiwa, and T. Komura

Subjects
Calcium Phosphates, Male, Urease, Struvite, Urology, Urinary system, chemistry.chemical_element, Magnesium Compounds, Urine, Calcium, law.invention, Phosphates, law, Humans, Crystallization, Incubation, Spinal Cord Injuries, Chromatography, biology, Chemistry, Magnesium, Hydrogen-Ion Concentration, Biochemistry, biology.protein, Composition (visual arts), Female
Abstract

An aggregometer technique was used to study urease-induced crystallizations in synthetic urine and human urine from healthy subjects and patients with chronic spinal cord injuries. The two different phases of crystallization, calcium phosphate and magnesium ammonium phosphate, were easily evaluated with a single assay using this technique. The crystallization of calcium phosphate and magnesium ammonium phosphate varied markedly among the different urine specimens after incubation with urease. The turbidity curves from human urine were divided into four patterns. We assumed that the variations in the patterns of the turbidity curves appeared to be mainly due to differences in the composition of the urine and in the original pH, and that the calcium and magnesium concentrations were very important in the urinary constituents.

Published
1997

24. Combined treatment of probucol with diltiazem regresses atherosclerosis induced by 196 cholesterol diet in rabbit aorta

Author

R, Kouzuma, H, Tasaki, T, Komura, Y, Nakashima, A, Kuroiwa, A, Tanimoto, and O, Koide

Subjects
Male, Time Factors, Arteriosclerosis, Anticholesteremic Agents, Lipoproteins, Cardiovascular Agents, Muscle, Smooth, Vascular, Cholesterol, Dietary, Diltiazem, Cholesterol, Probucol, Animals, Diet, Atherogenic, Drug Therapy, Combination, Rabbits, Aorta, Phospholipids, Triglycerides
Abstract

To clarify whether probucol, an antioxidant, or diltiazem, a Ca2+ antagonist, favorably affect the regression of established atherosclerosis, rabbits were fed a 1% cholesterol diet for 10 weeks, then a standard diet for an additional 25 weeks (regression period). During the regression period, rabbits were grouped into a saline (S) group (n=8, 1 ml saline/d), a probucol (P) group (n=8, 1000 mg/d probucol), or a probucol and diltiazem (P+D) group (n=8, probucol 1000 mg/d in diet and diltiazem 30 mg/d). We measured cholesterol in serum, lipoprotein fractions, and serum triglyceride or phospholipid concentration and found no significant differences among the three groups at 10, 15, or 35 weeks. After 10 weeks of the atherogenic diet, the ratio of macroscopic atherosclerotic lesions in aortic intima rose to 36.6 + or - 5.6%. After the regression period, the S group developed more atherosclerotic lesions (48.6 + or - 6.4%). The P+D and P groups, however, had decreased scores of 24.3 + or - 5.5% (p0.05 vs. S) and 32.3 + or - 5.6%, respectively. Moreover, these decreased scores were well correlated with the decrease in aortic tissue lipid compositions, but not the parameters for extracellular matrices. We concluded that P+D or P therapy might be effective in regressing established atherosclerosis by removing lipid contents but not extracellular matrices.

Published
1995

25. 125 Baseline bone metabolism markers as predictors for progression-free survival of patients with treatment-naïve bone-metastatic prostate cancer treated with zoledronic acid plus combined androgen blockade

Author

H. Kajikawa, M. Imanishi, M. Nozawa, A. Esa, Kazuhiro Nagao, M. Kitagawa, Hideyasu Matsuyama, T. Ogawa, Y. Uekado, T. Inagaki, T. Komura, Shigeya Uejima, T. Nishioka, Hirotsugu Uemura, and I. Hara

Subjects
Oncology, medicine.medical_specialty, business.industry, medicine.drug_class, Urology, Androgen, medicine.disease, Bone remodeling, Blockade, Therapy naive, Prostate cancer, Zoledronic acid, Internal medicine, medicine, Progression-free survival, business, medicine.drug
Published
2012
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26. Characteristics of the health conditions of old patients with spinal cord injury

Author

T, Komura, M, Yamasaki, S, Muraki, and K, Seki

Subjects
Adult, Male, Adolescent, Japan, Health Status, Surveys and Questionnaires, Age Factors, Humans, Female, Middle Aged, Health Surveys, Spinal Cord Injuries, Aged
Abstract

The state of health of old patients with spinal cord injury (SCI) was investigated to clarify the disorders that they are presently suffering from. A questionnaire was sent by mail to 668 patients with SCI living in western Japan. Valid answers were returned from 448 (67%), and they were divided into a young group (160 patients aged 18-39 years), middle-aged group (193 patients aged 40-59 years), and elderly group (95 patients aged 60-73). About 30% in the young group answered that they were ill or worrying about their health. This percentage was about 60% in the middle-aged and elderly groups. According to disease types, none of the young group had urological diseases except urological impairment or cardiovascular diseases, but many of the elderly group had urological tract infection, kidney diseases, cardiovascular diseases, and digestive diseases. Decubitus ulcer was reported in all groups. Urological diseases and decubitus ulcer were considered to be characteristic ailments of individuals with SCI. The elderly group was also characterized by a high incidence of adult diseases such as hypertension and diabetes mellitus. Therefore, the types of diseases and their frequency are considered to be different in older patients with SCI compared with the aged population in general because of the characteristic conditions of SCI in addition to adult diseases.

Published
1994

27. [A case of deoxycorticosterone-producing adrenal tumor]

Author

T, Komura, Y, Uekado, A, Suzuki, and M, Miyai

Subjects
Adenoma, Adrenal Gland Neoplasms, Humans, Female, Middle Aged, Desoxycorticosterone, Aldosterone
Abstract

We present a case of a 11-deoxycorticosterone (DOC)-producing adrenocortical tumor. A 55-year-old female was admitted to our hospital with the chief complaints of sustained hypertension and weakness of lower extremities. A laboratory study revealed a decrease in the serum potassium level and plasma renin activity, a normal level of plasma aldosterone and a significant elevation of plasma DOC and 18-OH-DOC levels. The plasma DOC level was increased by ACTH stimulation and was not suppressed by dexamethasone. The tumor appeared at a low intensity of the T1 weighted image of magnetic resonance imaging (MRI) and at a high intensity on the T2 weighted image. Left adrenalectomy was performed and histological examination revealed a benign adrenal adenoma. Postoperatively, the abnormal blood pressure, serum potassium level and plasma level of DOC and 18-OH-DOC became normal.

Published
1993

28. Daily energy expenditure in active and inactive persons with spinal cord injury

Author

M, Yamasaki, M, Irizawa, T, Komura, K, Kikuchi, H, Sasaki, K, Kai, and K, Ohdoko

Subjects
Adult, Male, Heart Rate, Activities of Daily Living, Humans, Middle Aged, Energy Metabolism, Life Style, Spinal Cord Injuries
Abstract

Daily energy expenditure (DEE) was evaluated seventeen male subjects with spinal cord injury (SSCI), who had active (N = 9) and inactive (N = 8) lifestyles, and in seven normal males. DEE was estimated from the mean 24-hr heart rate and heart rate-energy expenditure relationship determined in an arm cranking exercise. The DEE of SSCI on active days did not differ from those of normal subjects. On inactive days, SSCI had significantly lower DEE than on active days and than normal subjects. In contrast, the mean 24-hr heart rates of SSCI on active days and inactive SSCI were significantly greater than those of normal subjects, suggesting that SSCI, particularly inactive SSCI, exhibited a slight degree of tachycardia when compared to normal subjects. On inactive days, the DEE was fairly independent of the level of spinal cord injury. However, on active days, there was a clear tendency for SSCI with a low lesion level to have a higher DEE. Even if a SSCI with a high lesion level engaged in active sports, his DEE was relatively small. This lower DEE was largely attributable to the smaller functional muscle mass due to the limitation of physical activity.

Published
1992

29. [A case of retrovesical fibrosarcoma with severe hypoglycemia]

Author

A, Hirano, Y, Sawada, H, Aoshi, T, Komura, M, Matsumoto, Y, Kohjimoto, T, Inagaki, and T, Ohkawa

Subjects
Male, Urinary Bladder Neoplasms, Fibrosarcoma, Humans, Hypoglycemia, Aged
Abstract

We report a case of retrovesical fibrosarcoma with severe hypoglycemia. A 67-year-old man was admitted to our hospital with second recurrence of the retrovesical tumor with hypoglycemia. The episodes of hypoglycemia were accompanied by the advance of tumor size. Complete tumor resection with total cystectomy was performed on December 21, 1989, and the tumor was diagnosed histopathologically as fibrosarcoma. Soon after removal of the tumor, hypoglycemia disappeared and the patient has been well without local recurrence or distant metastasis for more than 20 months.

Published
1992

30. [A case of heterozygous familial hypercholesterolemia showing the regression of coronary atherosclerosis by LDL-apheresis]

Author

S, Nomura, R, Kouzuma, T, Komura, T, Sadayasu, J, Segawa, Y, Nakashima, and A, Kuroiwa

Subjects
Hyperlipoproteinemia Type II, Heterozygote, Blood Component Removal, Humans, Female, Cholesterol, LDL, Coronary Artery Disease, Coronary Angiography, Aged
Abstract

A case showing the regression of coronary atherosclerosis by the treatment with LDL-apheresis, was reported. The patient was a 67-year old female with heterozygous familial hypercholesterolemia. She had noticed the xanthelasma or left cubital xanthoma at the age of 50 years old. She was informed about her high serum cholesterol level (greater than 350 mg/dl), and the abnormal thickness of her bilateral achilles tendon at the age of 61 years. As her serum cholesterol level did not decrease sufficiently with several lipid-lowering drugs, she was referred to our hospital in order to obtain treatment for it by LDL-apheresis at the age of 66 years. LDL-apheresis was performed once every two weeks with drugs such as probucol, cholestyramine and pravastatin. Her coronary angiogram after two and half years of LDL-apheresis showed a decrease of the coronary narrowing in segment 1 and segment 13 (from 96.8% to 74.6% in segment 1, and from 81.5% to 61.7% in segment 13, respectively). The thickness of her bilateral achilles tendons had also decreased from 18 mm in the right and 19 mm in the left to 14 mm in both, after receiving LDL-apheresis for two and half years. It is suggested from the result of this case that the regression of coronary atherosclerosis could be expected after treatment with LDL-apheresis in hypercholesterolemic patients.

Published
1992

32. Changes in plasma vitamin E and thiobarbituric acid-reactive substances (TBARS) during a single and long-term repeated LDL-apheresis

Author

Akio Kuroiwa, Yasuhide Nakashima, T. Komura, A. Fujinishi, Akira Yashiro, Hiromi Tasaki, C. Ohba, Kazuhito Yamashita, and Kazuo Takahara

Subjects
medicine.medical_specialty, chemistry.chemical_compound, Endocrinology, LDL apheresis, Chemistry, Thiobarbituric acid, Vitamin E, medicine.medical_treatment, Internal medicine, medicine, TBARS, Cardiology and Cardiovascular Medicine
Published
1994
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34. Lisinopril, an ACE inhibitor, suppresses atherogenesis in the aorta but not the coronary arteries of chlolesterol-fed rabbits

Author

A. Fujinisji, Yasuhide Nakashima, T. Komura, Kazuo Takahara, Akio Kuroiwa, and Akira Yashiro

Subjects
medicine.medical_specialty, Aorta, business.industry, Lisinopril, Coronary arteries, medicine.anatomical_structure, Internal medicine, medicine.artery, ACE inhibitor, Cardiology, Medicine, Cardiology and Cardiovascular Medicine, business, medicine.drug
Published
1994
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38. Amorphous alloy powders with dispersed carbonitride particles prepared by high pressure nitrogen atomization

Author

Akihisa Inoue, T. Komura, T. Masumoto, D. Sun, and Masahiro Oguchi

Subjects
Materials science, Amorphous metal, Metallurgy, General Engineering, Niobium, chemistry.chemical_element, Vanadium, Raw material, Nitrogen, Amorphous solid, chemistry, Chemical engineering, Thermal stability, Particle size
Abstract

Amorphous alloy powders having f.c.c. V(C, N) and Nb(C, N) dispersed particles have been produced by N 2 atomization of Fe13P15C8Cr4Mo alloys including an easy carbonitride-forming element such as vanadium and niobium with a high dynamic pressure of 10 MPa. A critical diameter for the formation of the mixed-phase powders is 63 μm and the particle size and the interparticle distance of the carbonitrides are about 0.2 to 0.6 μm and 0.3 to 1.0 μm, respectively. No distinct degradation of the thermal stability of the amorphous phase by the coexistence of V(C, N) or Nb(C, N) particles is seen. The new processing technique and the resultant mixed-phase powders are expected to become significant as a raw material to produce a material having useful characteristics which are not obtained for an amorphous single phase.

Published
1988
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41. 3.An Experimental Study on Sclero Therapy to the Hemorrhoid

Author

Kinoshita, M. Kurosu, T. Sakabe, T. Komura, K. Katoh, S. Nishida, K. Kuroki, and H. Shimizu

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, Medicine, Surgery, business
Abstract

In Europe and America, 5 % Phenol-Almond Oil was used generally for the treatment of hemorrhoid and some clinical cases were reported of fair .results.In order to examine of hitological reaction in infused region this oil was injected in subcutanous tissue of colon in dogs and histological study was performed by lapse of times.

Published
1971
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42. Thermal Degradation of Sugars. Quantitative Analysis of Sugar Components and Determination of Degree of Polymerization*

Author

H. Sugisawa and T. Komura

Subjects
chemistry.chemical_classification, Polymerization, Chemistry, Materials Chemistry, Molecule, Degradation (geology), Organic chemistry, Polymer, Degree of polymerization, Sugar, Quantitative analysis (chemistry), Catalysis
Abstract

A quantitative analysis of sugar polymers formed by heating glucose without a catalyst for various times at 150° C was carried out. From the results, it is evident that glucose molecules rapidly polymerize to dissacharides and these sugars then undergo further polymerization to complex higher oligosaccharides.

Published
1970
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43. [Adrenal incidentaloma: report of eight cases]

Author

S, Morimoto, H, Aoshi, A, Hirano, T, Komura, I, Kyoku, T, Okawa, M, Kitagawa, S, Minakata, and T, Watanabe

Subjects
Adenoma, Adult, Male, Cysts, Adrenal Gland Neoplasms, Adrenalectomy, Pheochromocytoma, Middle Aged, Catecholamines, Renin, Humans, Female, Tomography, X-Ray Computed, Aged
Abstract

Since 1983, eight cases of adrenal incidentaloma were experienced at the Department of Urology, Wakayama Medical College and affiliated hospitals. Six adrenal masses were incidentally detected by computed tomography, and two were first noted by either ultrasonography or intravenous pyelography. Surgical exploration was performed in all cases as the final diagnostic measure. Of them, three had adrenocortical adenomas, three had adrenal cysts, one had adrenal metastasis and one had pheochromocytoma. Preoperative evaluation revealed that all patients except one with pheochromocytoma had no endocrinological abnormality. The management of the adrenal incidentaloma, which will be discovered more frequently accompanied with the increasing use of computed tomography, was discussed with special references to its precise indication of surgical treatment.

Published
1988

44. [Uroepithelial tumors of the upper urinary tract following bladder cancer]

Author

T, Shinka, S, Morimoto, Y, Uekado, T, Yoshida, K, Kumeda, A, Hirano, T, Komura, T, Watanabe, and T, Ohkawa

Subjects
Male, Neoplasms, Multiple Primary, Urethral Neoplasms, Urologic Neoplasms, Urinary Bladder Neoplasms, Ureteral Neoplasms, Urinary Bladder, Humans, Middle Aged, Urinary Diversion, Aged
Abstract

Five hundred and nineteen patients with primary bladder cancer were treated between January, 1969 and December, 1984, 12 of whom had developed upper urothelial tumors. These patients had received various transurethral treatment for the primary bladder lesions, except for one patient who had undergone total cystectomy and ileal conduit diversion. Overall incidence of patients with upper urinary tract tumors following bladder cancer was 2.3%. The incidence of patients with treated bladder tumors (13.2%) for dye workers was higher than that for the general population (1.1%). The interval between initial treatment of the bladder tumor and diagnosis of the upper tract tumor ranged from 7 to 170 months (mean 70 months). The incidence of upper tract tumors increased with the passage of time. We conclude that the occurrence of upper urinary tract tumors following primary bladder cancers is promoted by nonspecific chemical irritants against the urothelium already made unstable by certain urinary chemical carcinogens.

Published
1987

46. [Pharmacological studies on azosemide [5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)-phenyltetrazole], a new diuretic (1) Effects on diuresis, plasma renin activity and urinary prostaglandin E excretion in normal rats (author's transl)]

Author

Y, Suzuki, M, Ito, and T, Komura

Subjects
Male, Prostaglandins E, Indomethacin, Rats, Inbred Strains, Blood Urea Nitrogen, Diuresis, Rats, Electrolytes, Furosemide, Creatinine, Renin, Sulfanilamides, Animals, Diuretics
Abstract

Effects of azosemide on diuresis, plasma renin activity (PRA), and urinary prostaglandin E (PGE) excretion in normal rats and rats pretreated with indomethacin were studied in comparison with those of furosemide. Azosemide at doses ranging from 10 to 40 mg/kg p.o. dose-dependently increased urinary volume and Na+, K+, and Cl- excretions. In this case, the increases in urinary volume and Na+, K+, and Cl- excretions with 40 mg/kg of this drug were 3.4 and 4.1, 2.9, and 5.8 times, respectively. Pretreatment with indomethacin (10 mg/kg X 3 p.o.), a PG synthesis inhibitor, inhibited the increasing effects of this drug on urinary volume and Na+ and Cl-excretions by 80 or approximately 90%. Moreover, the increasing effects of this drug on PRA and urinary PGE excretion were also inhibited remarkably to the same degree by pretreatment with indomethacin. These effects of azosemide were roughly similar to those of furosemide. From these results, the diuretic action of azosemide, like that of furosemide, may partly be mediated through the activation of the PG system in kidney.

Published
1982

47. [Adenomatous polyps with prostatic type epithelium: a report of two cases]

Author

T, Komura, T, Yoshida, S, Morimoto, T, Shinka, and T, Ohkawa

Subjects
Male, Urethral Neoplasms, Polyps, Humans, Prostatic Neoplasms, Middle Aged
Abstract

Two cases of adenomatous polyps with prostatic type epithelium are reported. The first case was of a 62-year-old male suffering from asymptomatic hematuria. Cystoscopic findings showed an urethral tumor in the prostatic urethra. He was treated by transurethral resection of the prostate. The second case was of a 47-year-old male with complaints of hematuria and doubtful findings in urinary cytology. Cystoscopic findings showed that he had an urethral tumor in the prostatic urethra as well as bladder tumor. Both were resected transurethrally. Histological examination revealed that both urethral tumors were papillary adenoma of the prostatic urethra, corresponding to the adenomatous polyps with prostatic type epithelium in the classification of AFIP. The peroxidase-antiperoxidase complex method was performed using the anti-prostatic acid phosphatase antibody and anti-prostatic-specific antigen antibody, and positive reactions were obtained which confirmed that the tumors originated in the prostatic tissue. Benign urethral tumor in males is not common and description of adenomatous polyps with prostatic type epithelium is very rare. We could find only 11 cases in the Japanese literature.

Published
1987

49. [Pharmacological studies on diuretic action of azosemide [5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)-phenyltetrazole], a new diuretic (2). Diuretic action of azosemide in HgCl2-induced acute renal failure in rats]

Author

Y, Suzuki, M, Ito, and T, Komura

Subjects
Male, Furosemide, Mercuric Chloride, Sulfanilamides, Animals, Rats, Inbred Strains, Mercury, Acute Kidney Injury, Diuretics, Rats
Abstract

The diuretic effect of azosemide in HgCl2-induced acute renal failure of rats was investigated in comparison with that of furosemide. Acute renal failure was induced by the single s.c. injection of 1, 2, or 4 mg/kg HgCl2; and the test drug was administered 48 hr after treatment with HgCl2. Treatment with HgCl2 resulted in a dose related elevation of plasma urea nitrogen and creatinine levels (mg/dl). In rats with 1 mg/kg HgCl2-induced acute renal failure, azosemide at doses ranging from 10 to 40 mg/kg p.o. dose-dependently increased urinary volume (ml/5 hr) and urinary Na+, K+, and Cl- excretions (mEq/5 hr). In this case, azosemide at 40 mg/kg caused a 3.5-fold increase in urinary volume and 4.5-, 2.1, and 4.1-fold increases in urinary Na+, K+, and Cl- excretions, respectively. Although plasma electrolyte levels were little affected by azosemide, plasma urea nitrogen and creatinine levels were significantly elevated by doses of more than 20 mg/kg of this drug. The diuretic effect of azosemide was more markedly reduced in rats with 2 mg/kg HgCl2-induced acute renal failure than in rats with 1 mg/kg HgCl2-induced acute renal failure. In the case of treatment with HgCl2 of 2 mg/kg, the diuretic effect of azosemide at doses ranging from 40-320 mg/kg p.o. was dose-dependent. However, azosemide had no effect on plasma electrolyte, urea nitrogen, and creatinine levels. The diuretic effect of azosemide in rats given 4 mg/kg HgCl2 was more pronouncedly reduced as compared with that in the case of 2 mg/kg HgCl2. In this case, azosemide at 320 mg/kg brought about a 2.6-fold increase in urinary volume and 4.8-, 4.6-, and 3.9-fold increases in urinary Na+, K+, and Cl- excretions, respectively. This drug had no effect on any plasma parameters. The diuretic effect of azosemide was slightly more potent than those of furosemide in the case of acute renal failure induced by 2 and 4 mg/kg HgCl2.

Published
1982

50. [Foreign body in the kidney: report of a case]

Author

I, Kyoku, T, Fukatani, S, Yasukawa, H, Aoshi, A, Hirano, T, Komura, and T, Yamauchi

Subjects
Male, Accidents, Occupational, Humans, Middle Aged, Foreign Bodies, Kidney, Tomography, X-Ray Computed
Abstract

A 49-year-old man was admitted with the suspicion of renal foreign body. A fragment of wire rope was penetrated from his right lumbar region while working. Drip infusion pyelography and computed tomography films revealed a linear metallic object in the region of the right kidney. The foreign body was successfully extracted from the right renal parenchyma. The 38 cases of foreign bodies in the upper urinary tract including 12 in the renal parenchyma found in the literature are reviewed.

Published
1988

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