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14,828 results on '"T, Inoue"'

1. Electrical conductivity anisotropy of InGaZn3O6 single crystals by pressurized optical floating zone growth and its oxygen annealing effect

Author

N. Kase, Y. Kawamura, Y. Kobayashi, T. Inoue, K. Tanaka, and N. Miyakawa

Subjects
Biotechnology, TP248.13-248.65, Physics, QC1-999
Abstract

Large bulk single crystals of InGaZn3O6 (InGaO3(ZnO)3 or IGZO-13) have been successfully grown using an optical floating zone method under a flow of dry-air at high pressure. These crystals exhibit a distinct blue hue in their as-grown state, with notable enhancement in transparency attainable through O2 annealing. Comparative analysis with IGZO-11 reveals a substantial reduction in conductivity following O2 annealing. Moreover, a pronounced in-plane/out-of-plane conductive anisotropy ranging from 100 to 450 is observed, surpassing that of IGZO-11 under similar in-plane conductivity conditions. This increase in electrical conducting anisotropy is ascribed to the incorporation of ZnO blocks amid the two InO layers, aligned along the c axis. Based on these findings, it is concluded that the contribution of In-5s orbitals likely assumes a predominant role, surpassing that of other cations from an experimental standpoint.

Published
2024
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2. Estudo do Inversor ĆUK Integrado Monofásico em Operação Autônoma no Modo de Condução Descontínua

Author

Rafael T. Inoue, Anderson A. Dionizio, Leonardo P. Sampaio, Sérgio A. O. da Silva, Moacyr A. G. de Brito, and Guilherme M. Pelz

Subjects
conversor ćuk, inversor de único estágio, inversor integrado, inversor monofásico, modo de condução descontínua, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

Estruturas de inversores integrados vêm sendo amplamente adotados na interface de fontes de energia elétrica em CC com aplicações em CA. Desta forma, este trabalho contribui com estudos acerca do inversor Ćuk integrado (ICI) monofásico, apresentando a modelagem da estrutura, além de uma nova estratégia de comutação para os interruptores de potência. O ICI é projetado para operar no modo de condução descontinua, bem como para atuar de forma autônoma, a fim de fornecer tensão senoidal e controlada para cargas locais em CA. A partir da modelagem em espaço de estados, é obtida a função de transferência do inversor, bem como projetado o controlador de tensão. O ICI se destaca por: i) empregar menor número de componentes; ii) operar somente com um interruptor em alta frequência; iii) ser capaz de elevar a tensão de entrada e fornecer uma tensão senoidal de forma simultânea. Por meio de resultados de simulações computacionais e experimentais, a viabilidade do ICI é avaliada e validada. Os testes experimentais demonstram que o ICI possui elevado rendimento e é capaz de fornecer uma tensão senoidal com baixa distorção harmônica.

Published
2024
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3. THE EFFECT OF CULTURE-SPECIFIC DIFFERENCES IN URBAN STREETSCAPES ON THE INFERENCE ACCURACY OF DEEP LEARNING MODELS

Author

T. Inoue, R. Manabe, A. Murayama, and H. Koizumi

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Owing to the increasing focus on places in urban planning and design, methods to evaluate the quality and value of urban places is crucially needed. Many studies use deep learning models to identify the proportion and composition of landscape elements in images for evaluation. The accuracy of semantic segmentation achieved with such models is often validated using Cityscapes, a street-level image dataset taken from German cities. However, few studies have quantitatively revealed the inference accuracy decrease caused by culture-specific characteristics of streetscapes.In this study, we calculated by-class intersection over union (IoU) and newly-defined indices of false inferences to demonstrate how and to what extent deep learning models can infer each landscape element falsely when applied to Japanese street-level images. Our analysis revealed that certain landscape elements are more difficult to infer correctly based on specific causes, such as their appearances in images and unique characteristics of the fixed physical configuration of Japanese streets. By applying the false inference categorization framework presented in this study, researchers can adjust their approaches considering two aspects: a decrease in inference accuracies of deep learning models and the impact of culture-specific characteristics of streetscapes on people's perception and valuation of urban places. Based on the results and analyses, a future research direction is to develop and implement more accurate image recognition models considering culture-specific characteristics to understand people's perceptions of urban spaces and assess the value of urban places by using the big data including street-level images.

Published
2022
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4. Cloud–Cloud Collision: Formation of Hub-filament Systems and Associated Gas Kinematics. Mass-collecting Cone—A New Signature of Cloud–Cloud Collision

Author

A. K. Maity, T. Inoue, Y. Fukui, L. K. Dewangan, H. Sano, R. I. Yamada, K. Tachihara, N. K. Bhadari, and O. R. Jadhav

Subjects
Magnetohydrodynamics, Interstellar filaments, Star formation, Massive stars, Astrophysics, QB460-466
Abstract

Massive star-forming regions (MSFRs) are commonly associated with hub-filament systems (HFSs) and sites of cloud–cloud collision (CCC). Recent observational studies of some MSFRs suggest a possible connection between CCC and the formation of HFSs. To understand this connection, we analyzed the magnetohydrodynamic simulation data from Inoue et al. This simulation involves the collision of a spherical turbulent molecular cloud with a plane-parallel sea of dense molecular gas at a relative velocity of about 10 km s ^−1 . Following the collision, the turbulent and nonuniform cloud undergoes shock compression, rapidly developing filamentary structures within the compressed layer. We found that CCC can lead to the formation of HFSs, which is the combined effect of turbulence, shock compression, magnetic field, and gravity. The collision between the cloud components shapes the filaments into a cone and drives inward flows among them. These inward flows merge at the vertex of the cone, rapidly accumulating high-density gas, which can lead to the formation of massive star(s). The cone acts as a mass-collecting machine, involving a nongravitational early process of filament formation, followed by gravitational gas attraction to finalize the HFS. The gas distribution in the position–velocity (PV) and position–position spaces highlights the challenges in detecting two cloud components and confirming their complementary distribution if the colliding clouds have a large size difference. However, such CCC events can be confirmed by the PV diagrams presenting gas flow toward the vertex of the cone, which hosts gravitationally collapsing high-density objects, and by the magnetic field morphology curved toward the direction of the collision.

Published
2024
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5. Choice of 16S Ribosomal RNA Primers Impacts Male Urinary Microbiota Profiling

Author

Vitor Heidrich, Lilian T. Inoue, Paula F. Asprino, Fabiana Bettoni, Antonio C. H. Mariotti, Diogo A. Bastos, Denis L. F. Jardim, Marco A. Arap, and Anamaria A. Camargo

Subjects
urobiome, urinary microbiota, bladder microbiota, 16S amplicon sequencing, 16S rRNA primers, Microbiology, QR1-502
Abstract

Accessibility to next-generation sequencing (NGS) technologies has enabled the profiling of microbial communities living in distinct habitats. 16S ribosomal RNA (rRNA) gene sequencing is widely used for microbiota profiling with NGS technologies. Since most used NGS platforms generate short reads, sequencing the full-length 16S rRNA gene is impractical. Therefore, choosing which 16S rRNA hypervariable region to sequence is critical in microbiota profiling studies. All nine 16S rRNA hypervariable regions are taxonomically informative, but due to variability in profiling performance for specific clades, choosing the ideal 16S rRNA hypervariable region will depend on the bacterial composition of the habitat under study. Recently, NGS allowed the identification of microbes in the urinary tract, and urinary microbiota has become an active research area. However, there is no current study evaluating the performance of different 16S rRNA hypervariable regions for male urinary microbiota profiling. We collected urine samples from male volunteers and profiled their urinary microbiota by sequencing a panel of six amplicons encompassing all nine 16S rRNA hypervariable regions. Systematic comparisons of their performance indicate V1V2 hypervariable regions better assess the taxa commonly present in male urine samples, suggesting V1V2 amplicon sequencing is more suitable for male urinary microbiota profiling. We believe our results will be helpful to guide this crucial methodological choice in future male urinary microbiota studies.

Published
2022
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6. Alluvial cover on bedrock channels: applicability of existing models

Author

J. Mishra and T. Inoue

Subjects
Dynamic and structural geology, QE500-639.5
Abstract

Several studies have demonstrated the importance of alluvial cover; furthermore, several mathematical models have also been introduced to predict the alluvial cover on bedrock channels. Here, we provide an extensive review of research exploring the relationship between alluvial cover, sediment supply and bed topography of bedrock channels, describing various mathematical models used to analyse the deposition of alluvium. To test one-dimensional theoretical models, we performed a series of laboratory-scale experiments with varying bed roughness under simple conditions without bar formation. Our experiments show that alluvial cover is not merely governed by increasing sediment supply and that bed roughness is an important controlling factor of alluvial cover. A comparison between the experimental results and the five theoretical models shows that (1) two simple models that calculate alluvial cover as a linear or exponential function of the ratio of the sediment supplied to the capacity of the channel produce good results for rough bedrock beds but not for smoother bedrock beds; (2) two roughness models which include changes in roughness with alluviation and a model including the probability of sediment accumulation can accurately predict alluvial cover in both rough and smooth beds; and (3), however, except for a model using the observed hydraulic roughness, it is necessary to adjust model parameters even in a straight channel without bars.

Published
2020
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7. Subsidence of rice paddy and upland crop fields in Shinotsu Peatland, Hokkaido, Japan

Author

M. Yokochi, K. Sekimoto, and T. Inoue

Subjects
Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract

Agricultural land use on peatlands inevitably causes ongoing land surface subsidence resulting in a reduction of productivity. In addition, oxidation of the peat substrate associated with subsidence is responsible for greenhouse gas emission with the ensuing consequence for global climatic stability. A concept of “paludiculture”, the utilisation of wet or rewetted peatlands for agriculture, has been proposed in European countries to avoid further subsidence and greenhouse gas emission. However, few studies have documented a long-term record of subsidence through agriculture in wet peatlands such as paddy fields for rice cultivation. In this study, we measured the subsidence rates of peatland in rice paddy use and compared them to the rates in peatland with upland crop cultivation. The average subsidence between 2006 and 2016 for the paddy plots was 3.6±1.9 cm (± SE) and significantly less than that of 25.6±1.7 cm for the upland plots, and the subsidence reduced linearly as the period of paddy use increased. These results suggest that paddy use of peatlands can effectively reduce subsidence. Our results will encourage the use of peatlands with a wet environment as one of the valid options for future peatland management in terms of mitigation of land subsidence and peat loss.

Published
2020
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8. ALMA Observations of Supernova Remnant N49 in the Large Magellanic Cloud. II. Non-LTE Analysis of Shock-heated Molecular Clouds

Author

H. Sano, Y. Yamane, J. Th. van Loon, K. Furuya, Y. Fukui, R. Z. E. Alsaberi, A. Bamba, R. Enokiya, M. D. Filipović, R. Indebetouw, T. Inoue, A. Kawamura, M. Lakićević, C. J. Law, N. Mizuno, T. Murase, T. Onishi, S. Park, P. P. Plucinsky, J. Rho, A. M. S. Richards, G. Rowell, M. Sasaki, J. Seok, P. Sharda, L. Staveley-Smith, H. Suzuki, T. Temim, K. Tokuda, K. Tsuge, and K. Tachihara

Subjects
Supernova remnants, Interstellar medium, Molecular clouds, X-ray sources, Astrophysics, QB460-466
Abstract

We present the first compelling evidence of shock-heated molecular clouds associated with the supernova remnant (SNR) N49 in the Large Magellanic Cloud (LMC). Using ^12 CO( J = 2–1, 3–2) and ^13 CO( J = 2–1) line emission data taken with the Atacama Large Millimeter/Submillimeter Array, we derived the H _2 number density and kinetic temperature of eight ^13 CO-detected clouds using the large velocity gradient approximation at a resolution of 3.″5 (∼0.8 pc at the LMC distance). The physical properties of the clouds are divided into two categories: three of them near the shock front show the highest temperatures of ∼50 K with densities of ∼500–700 cm ^−3 , while other clouds slightly distant from the SNR have moderate temperatures of ∼20 K with densities of ∼800–1300 cm ^−3 . The former clouds were heated by supernova shocks, but the latter were dominantly affected by the cosmic-ray heating. These findings are consistent with the efficient production of X-ray recombining plasma in N49 due to thermal conduction between the cold clouds and hot plasma. We also find that the gas pressure is roughly constant except for the three shock-engulfed clouds inside or on the SNR shell, suggesting that almost no clouds have evaporated within the short SNR age of ∼4800 yr. This result is compatible with the shock-interaction model with dense and clumpy clouds inside a low-density wind bubble.

Published
2023
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9. Superior mechanical resistance in the exoskeleton of the coconut crab, Birgus latro

Author

T. Inoue, T. Hara, K. Nakazato, and S. Oka

Subjects
Biomineralization, Tissue structure, Crustacean cuticle, Nanoindentation, Structure-property relations, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

The hierarchical tissue structure that can balance the lightweight and strength of organisms gives hints on the development of biologically inspired materials. The exoskeleton of the coconut crab, Birgus latro, which is the largest terrestrial crustacean, was systematically analyzed using a materials science approach. The tissue structures, chemical compositions, and mechanical properties of the claw, walking legs, cephalothorax, and abdomen were compared. The local mechanical properties, hardness(H) and stiffness(E), were examined by nanoindentation testing. The stacking height, Sh, of the twisted plywood structure observed only in the exocuticle, the exoskeleton thickness, and the thickness and compositions at each layer differed significantly by body part. The exocuticle is strongly mineralized regardless of body parts. The claw and walking legs were thicker than the cephalothorax and abdomen, and their endocuticle was mineralized as compared to the endocuticle in the cephalothorax and abdomen. The H and Sh had a correlation in the exocuticle layer, and the H increased with decreasing the Sh. On the H−E map for abrasion resistance of materials, the results showed that the exocuticle layer of the coconut crab was superior to that of other arthropods and all engineering polymers and competitive with the hardest metallic alloys.

Published
2021
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10. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry

Author

Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, Alex Spyropoulos, John Eikelboom, Ramon Corbalan, Dayi Hu, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Sanjay Kakkar, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, D.Y. Hu, K.N. Chen, Y.S. Zhao, H.Q. Zhang, J.Z. Chen, S.P. Cao, D.W. Wang, Y.J. Yang, W.H. Li, Y.H. Yin, G.Z. Tao, P. Yang, Y.M. Chen, S.H. He, Ying Wang, Yong Wang, G.S. Fu, X. Li, T.G. Wu, X.S. Cheng, X.W. Yan, R.P. Zhao, M.S. Chen, L.G. Xiong, P. Chen, Y. Jiao, Y. Guo, L. Xue, F.Z. Wang, H. Li, Z.M. Yang, C.L. Bai, J. Chen, J.Y. Chen, X. Chen, S. Feng, Q.H. Fu, X.J. Gao, W.N. Guo, R.H. He, X.A. He, X.S. Hu, X.F. Huang, B. Li, J. Li, L. Li, Y.H. Li, T.T. Liu, W.L. Liu, Y.Y. Liu, Z.C. Lu, X.L. Luo, T.Y. Ma, J.Q. Peng, X. Sheng, X.J. Shi, Y.H. Sun, G. Tian, K. Wang, L. Wang, R.N. Wu, Q. Xie, R.Y. Xu, J.S. Yang, L.L. Yang, Q. Yang, Y. Ye, H.Y. Yu, J.H. Yu, T. Yu, H. Zhai, Q. Zhan, G.S. Zhang, Q. Zhang, R. Zhang, Y. Zhang, W.Y. Zheng, B. Zhou, Z.H. Zhou, X.Y. Zhu, S. Kakkar, J.P.S. Sawhney, P. Jadhav, R. Durgaprasad, A.G. Ravi Shankar, R.K. Rajput, K. Bhargava, R. Sarma, A. Srinivas, D. Roy, U.M. Nagamalesh, M. Chopda, R. Kishore, G. Kulkarni, P. Chandwani, R.A. Pothiwala, M. Padinhare Purayil, S. Shah, K. Chawla, V.A. Kothiwale, B. Raghuraman, G. Vijayaraghavan, V.M. Vijan, G. Bantwal, V. Bisne, A. Khan, J.B. Gupta, S. Kumar, D. Jain, S. Abraham, D. Adak, A. Barai, H. Begum, P. Bhattacharjee, M. Dargude, D. Davies, B. Deshpande, P. Dhakrao, V. Dhyani, S. Duhan, M. Earath, A. Ganatra, S. Giradkar, V. Jain, R. Karthikeyan, L. Kasala, S. Kaur, S. Krishnappa, A. Lawande, B. Lokesh, N. Madarkar, R. Meena, P. More, D. Naik, K. Prashanth, M. Rao, N.M. Rao, N. Sadhu, D. Shah, M. Sharma, P. Shiva, S. Singhal, S. Suresh, V. Vanajakshamma, S.G. Panse, Y. Koretsune, S. Kanamori, K. Yamamoto, K. Kumagai, Y. Katsuda, K. Sadamatsu, F. Toyota, Y. Mizuno, I. Misumi, H. Noguchi, S. Ando, T. Suetsugu, M. Minamoto, Hiroshi Oda, K. Shiraishi, S. Adachi, K. Chiba, H. Norita, M. Tsuruta, T. Koyanagi, H. Ando, T. Higashi, K. Okada, S. Azakami, S. Komaki, K. Kumeda, T. Murayama, J. Matsumura, Y. Oba, R. Sonoda, K. Goto, K. Minoda, Y. Haraguchi, H. Suefuji, H. Miyagi, H. Kato, Tadashi Nakamura, Tsugihiro Nakamura, H. Nandate, R. Zaitsu, Yoshihisa Fujiura, A. Yoshimura, H. Numata, J. Ogawa, H. Tatematsu, Y. Kamogawa, K. Murakami, Y. Wakasa, M. Yamasawa, H. Maekawa, S. Abe, H. Kihara, S. Tsunoda, Katsumi Saito, Kazuyuki Saito, T. Fudo, K. Obunai, H. Tachibana, I. Oba, T. Kuwahata, S. Higa, M. Gushiken, T. Eto, H. Yoshida, D. Ikeda, Yoshitake Fujiura, M. Ishizawa, M. Nakatsuka, K. Murata, C. Ogurusu, M. Shimoyama, M. Akutsu, I. Takamura, F. Hoshino, N. Yokota, T. Iwao, K. Tsuchida, M. Takeuchi, Y. Hatori, Y. Kitami, Yoichi Nakamura, R. Oyama, M. Ageta, Hiroyuki Oda, Y. Go, K. Mishima, T. Unoki, S. Morii, Yuhei Shiga, H. Sumi, T. Nagatomo, K. Sanno, K. Fujisawa, Y. Atsuchi, T. Nagoshi, T. Seto, T. Tabuchi, M. Kameko, K. Nii, K. Oshiro, H. Takezawa, S. Nagano, N. Miyamoto, M. Iwaki, Yuichiro Nakamura, M. Fujii, M. Okawa, Masahiko Abe, Masatake Abe, Mitsunori Abe, T. Saito, T. Mito, K. Nagao, J. Minami, T. Mita, I. Sakuma, T. Taguchi, S. Marusaki, H. Doi, M. Tanaka, T. Fujito, M. Matsuta, T. Kusumoto, S. Kakinoki, K. Ashida, N. Yoshizawa, J. Agata, O. Arasaki, M. Manita, M. Ikemura, S. Fukuoka, H. Murakami, S. Matsukawa, Y. Hata, T. Taniguchi, T. Ko, H. Kubo, M. Imamaki, M. Akiyama, M. Inagaki, H. Odakura, T. Ueda, Y. Katsube, A. Nakata, H. Watanabe, M. Techigawara, M. Igarashi, K. Taga, T. Kimura, S. Tomimoto, M. Shibuya, M. Nakano, K. Ito, T. Seo, S. Hiramitsu, H. Hosokawa, M. Hoshiai, M. Hibino, K. Miyagawa, Hajime Horie, N. Sugishita, Yukio Shiga, A. Soma, K. Neya, Tetsuro Yoshida, Tomoki Yoshida, M. Mizuguchi, M. Ishiguro, T. Minagawa, M. Wada, H. Mukawa, F. Okuda, S. Nagasaka, Y. Abe, Sen Adachi, Susumu Adachi, T. Adachi, K. Akahane, T. Amano, K. Aoki, T. Aoyama, H. Arai, S. Arima, T. Arino, H. Asano, T. Asano, J. Azuma, T. Baba, T. Betsuyaku, H. Chibana, H. Date, J. Doiuchi, Y. Emura, M. Endo, Y. Fujii, R. Fujiki, A. Fujisawa, Y. Fujisawa, T. Fukuda, T. Fukui, N. Furukawa, T. Furukawa, W. Furumoto, T. Goto, M. Hamaoka, N. Hanazono, K. Hasegawa, T. Hatsuno, Y. Hayashi, K. Higuchi, K. Hirasawa, H. Hirayama, M. Hirose, S. Hirota, M. Honda, Hideki Horie, T. Ido, O. Iiji, H. Ikeda, K. Ikeda, K. Ikeoka, M. Imaizumi, H. Inaba, T. Inoue, F. Iseki, A. Ishihara, N. Ishioka, N. Ito, T. Iwase, H. Kakuda, J. Kamata, H. Kanai, H. Kanda, M. Kaneko, H. Kano, T. Kasai, T. Kato, Y. Kato, Y. Kawada, K. Kawai, K. Kawakami, S. Kawakami, T. Kawamoto, S. Kawano, J. Kim, T. Kira, H. Kitazawa, H. Kitazumi, T. Kito, T. Kobayashi, T. Koeda, J. Kojima, H. Komatsu, I. Komatsu, Y. Koshibu, T. Kotani, T. Kozuka, Y. Kumai, T. Kumazaki, I. Maeda, K. Maeda, Y. Maruyama, S. Matsui, K. Matsushita, Y. Matsuura, K. Mineoi, H. Mitsuhashi, N. Miura, S. Miyaguchi, S. Miyajima, H. Miyamoto, A. Miyashita, S. Miyata, I. Mizuguchi, A. Mizuno, T. Mori, O. Moriai, K. Morishita, O. Murai, Sho Nagai, Shunichi Nagai, E. Nagata, H. Nagata, A. Nakagomi, S. Nakahara, M. Nakamura, R. Nakamura, N. Nakanishi, T. Nakayama, R. Nakazato, T. Nanke, J. Nariyama, Y. Niijima, H. Niinuma, Y. Nishida, Y. Nishihata, K. Nishino, H. Nishioka, K. Nishizawa, I. Niwa, K. Nomura, S. Nomura, M. Nozoe, T. Ogawa, N. Ohara, M. Okada, K. Okamoto, H. Okita, M. Okuyama, H. Ono, T. Ono, Y. Onuki Pearce, S. Oriso, A. Ota, E. Otaki, Y. Saito, H. Sakai, N. Sakamoto, Y. Sakamoto, Y. Samejima, Y. Sasagawa, H. Sasaguri, A. Sasaki, T. Sasaki, Kazuki Sato, Kiyoharu Sato, M. Sawano, S. Seki, Y. Sekine, Y. Seta, K. Sezaki, N. Shibata, Y. Shiina, H. Shimono, Y. Shimoyama, T. Shindo, H. Shinohara, R. Shinohe, T. Shinozuka, T. Shirai, T. Shiraiwa, Y. Shozawa, T. Suga, C. Sugimoto, Kazuo Suzuki, Keita Suzuki, Shu Suzuki, Shunji Suzuki, Susumu Suzuki, Y. Suzuki, M. Tada, A. Taguchi, T. Takagi, Y. Takagi, K. Takahashi, S. Takahashi, H. Takai, C. Takanaka, S. Take, H. Takeda, K. Takei, K. Takenaka, T. Tana, G. Tanabe, K. Taya, H. Teragawa, S. Tohyo, S. Toru, Y. Tsuchiya, T. Tsuji, K. Tsuzaki, H. Uchiyama, O. Ueda, Y. Ueyama, N. Wakaki, T. Wakiyama, T. Washizuka, M. Watanabe, T. Yamada, T. Yamagishi, H. Yamaguchi, Kenichi Yamamoto, Kentaro Yamamoto, Kunihiko Yamamoto, T. Yamamoto, M. Yamaura, M. Yamazoe, K. Yasui, Y. Yokoyama, K. Yoshida, T.W. Lim, C.K. Ching, C.G. Foo, J.H. Chow, D.D. Chen, F.R. Jaufeerally, Y.M. Lee, G. Lim, W.T. Lim, S. Thng, S.Y. Yap, C. Yeo, S. Oh, H.N. Pak, J.-B. Kim, J.H. Kim, S.-W. Jang, D.H. Kim, D.R. Ryu, S.W. Park, D.-K. Kim, D.J. Choi, Y.S. Oh, M.-C. Cho, S.-H. Kim, H.-K. Jeon, D.-G. Shin, J.S. Park, H.K. Park, S.-J. Han, J.H. Sung, J.-G. Cho, G.-B. Nam, Y.K. On, H.E. Lim, J.J. Kwak, T.-J. Cha, T.J. Hong, S.H. Park, J.H. Yoon, N.-H. Kim, K.-S. Kim, B.C. Jung, G.-S. Hwang, C.-J. Kim, D.B. Kim, J.J. Ahn, H.J. An, H. Bae, A.L. Baek, W.J. Chi, E.A. Choi, E.H. Choi, H.K. Choi, H.S. Choi, S. Han, E.S. Heo, K.O. Her, S.W. Hwang, E.M. Jang, H.-S. Jang, S. Jang, H.-G. Jeon, S.R. Jeon, Y.R. Jeon, H.K. Jeong, I.-A. Jung, Hyeon Jeong Kim, Hyun Ju Kim, Ji Seon Kim, Jung Sook Kim, J.A. Kim, K.T. Kim, M.S. Kim, Sang Hee Kim, Sang Hyun Kim, Y.-I. Kim, C.S. Lee, E.H. Lee, G.H. Lee, H.Y. Lee, H.-Y. Lee, K.H. Lee, K.R. Lee, M.S. Lee, M.-Y. Lee, R.W. Lee, S.E. Lee, S.H. Lee, S. Lee, W.Y. Lee, I.K. Noh, A.R. Park, B.R. Park, H.N. Park, J.H. Park, M. Park, Y. Park, S.-Y. Seo, J. Shim, J.H. Sim, Y.M. Sohn, W.S. Son, Y.S. Son, H.J. Song, H.K. Wi, J.J. Woo, S. Ye, K.H. Yim, K.M. Yoo, E.J. Yoon, S.Y. Yun, P. Angchaisuksiri, S. Chawanadelert, P. Mongkolwongroj, K. Kanokphatcharakun, S. 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Nathani, M. Ibrahim, E.M. Esheiba, R. Singh, A. Naguib, M. Abu-Mahfouz, M. Al Omairi, A. Al Naeemi, R. Maruthanayagam, N. Bazargani, A. Wassef, R. Gupta, M. Khan, B. Subbaraman, A. Abdul, A. Al Mulla, S. El Bardisy, P. Haridas, S. Jadhav, K. Magdaluyo, M. Makdad, I. Maqsood, R. Mohamed, N. Sharma, R. Sharma, M. Thanzeel, S.Z. Goldhaber, R. Canosa, P. Rama, E. Blumberg, J. Garcia, P. Mullen, V. Wilson, A. Quick, K. Ferrick, W.M. Kutayli, M. Cox, M. Franco, S. Falkowski, R. Mendelson, M. Williams, S. Miller, S. Beach, A. Alfieri, T. Gutowski, I. Haque, R. Reddy, W. Ahmed, P. Delafontaine, D. Diercks, D. Theodoro, K. Remmel, M. Alberts, R. Ison, H. Noveck, P. Duffy, S. Pitta, D. Nishijima, C. Treasure, N. Asafu-Adjaye, K. Ball, M. Bartlett, M. Bentley, S. Bowers, A. Brown, A. Browne, J. Cameron-Watts, M. Canova, D. Cassidy, K. Cervellione, S. Congal, J. DePauw, A. Dickerson, M. Eley, L. Evans, S. Felpel, K. Ferdinand, D. Fielder, P. Gentry, A. Haideri, F. Hakimi, T. Harbour, E. Hartranft, B. Hawkins, M. Headlee, L. Henson, C. Herrick, T. Hicks, S. Jasinski, A. Jones, L. Jones, P. Jones, S. Karl, M. Keeling, J. Kerr, P. Knowles, J. Langdon, M. Lay, J.A. Lee, T. Lincoln, E. Malone, A. Merliss, D. Merritt, J. Minardo, B. Mooso, C. Orosco, V. Palumbo, M. Parker, T. Parrott, S. Paserchia, G. Pearl, J. Peterson, N. Pickelsimer, T. Purcell, J. Raynor, S. Raziano, C. Richard, T. Richardson, C. Robertson, A. Sage, T. Sanghera, P. Shaw, J. Shoemaker, K. Smith, B. Stephanie, A. Thatcher, H. Theobald, N. Thompson, L. Treasure, T. Tripti, C. Verdi, and V. Worthy

Subjects
Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P

Published
2018
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11. Synthesis and Characterization of Zinc, Iron, Copper, and Manganese Oxides Nanoparticles for Possible Application as Plant Fertilizers

Author

Michel E. Neto, David W. Britt, Kyle A. Jackson, João H. V. Almeida Junior, Rodrigo S. Lima, Dimas A. M. Zaia, Tadeu T. Inoue, and Marcelo A. Batista

Subjects
Article Subject, General Materials Science
Abstract

This research evaluates the synthesis and characterization of nanometric-sized metallic particles with potential application as support materials for supplying nutrients to plants. Nanoscale Zn, Mn, Fe, and Cu oxides particles were synthesized using microwave-assisted synthesis. Nanoparticles (NPs) were characterized with Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), specific surface area (SSA), and total chemical analysis. Synthesized NPs were all in oxide forms and characterized for confirmation of size, shape, surface structure, crystalline nature, and study of elemental proportion. The results indicate that synthesized NPs size was ranged between 20 and 50 nm and was all in their respective oxide forms as ZnO, Mn3O4, Fe3O4, and CuO.

Published
2023

14. Factors and outcomes associated with improved left ventricular systolic function in patients with cardiomyopathy

Author

Dylan Eiger, Daniel P. Fishbein, Zainab Samad, Jeanne E. Poole, Kerry L. Lee, Daniel Friedman, Sana M. Al-Khatib, Gillian D Sanders, Daniel B. Mark, Qijun Li, Lurdes Y. T. Inoue, and Gust H. Bardy

Subjects
medicine.medical_specialty, medicine.medical_treatment, Cardiomyopathy, Placebo, Ventricular Function, Left, Sudden cardiac death, QRS complex, Risk Factors, Internal medicine, Humans, Medicine, In patient, cardiovascular diseases, Heart Failure, Ejection fraction, business.industry, Stroke Volume, General Medicine, medicine.disease, Implantable cardioverter-defibrillator, humanities, Defibrillators, Implantable, Death, Sudden, Cardiac, Heart failure, cardiovascular system, Cardiology, Female, Cardiomyopathies, Cardiology and Cardiovascular Medicine, business, therapeutics, circulatory and respiratory physiology
Abstract

Background: Many patients in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) had a significant improvement (> 10%) in the left ventricular ejection fraction (LVEF) during the course of the study, but the factors and outcomes associated with such improvement are uncertain. Methods: We examined factors and rates of mortality, cause-specific mortality, and implantable cardioverter defibrillator (ICD) shocks associated with improvement in LVEF by analyzing patients in the SCD-HeFT who were randomized to placebo or an ICD and who had an LVEF checked during follow-up. Results: During a median follow-up of 3.99 years, of 837 patients who had at least two follow-up LVEF measurements, 276 (33%) patients had > 10% improvement in LVEF and 561 (67%) patients had no significant change in LVEF. Factors significantly associated with LVEF improvement included female sex, white race, history of hypertension, a QRS duration < 120 ms, and beta-blocker use. Improvement in LVEF was associated with a significant improvement in survival. There was no significant association between improvement in LVEF and cause-specific death, but there was a significant association between improvement in LVEF and reduced risk of receiving appropriate ICD shocks. Conclusions: About a third of patients in this analysis, who were randomized to placebo or an ICD in SCD-HeFT, had a significant improvement in LVEF during follow-up; improvement in LVEF was associated with improved survival but not with cause-specific death, and with decreased likelihood of receiving appropriate ICD shocks.

Published
2022

19. The effect of levofloxacin for patients with non-muscle invasive bladder cancer treated by intravesical Bacillus Calmette-Guerin: Results of a randomized, prospective, multicenter study

Author

K. Numakura, M. Kobayashi, T. Ishida, K. Okane, K. Suzuki, N. Shimoda, T. Kumazawa, T. Suzuki, R. Sasaki, H. Fukuda, T. Nara, S. Kanda, M. Huang, M. Saito, S. Narita, T. Inoue, N. Tsuchiya, and T. Habuchi

Subjects
Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published
2020
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21. The impact of phosphatidylinositol phosphate and its associated enzyme levels on clinical outcomes in patients with renal cell carcinoma who underwent surgery

Author

N.S. Narita, H. Nakanishi, Y. Matsuda, M. Huang, A. Koizumi, A. Kikuchi, R. Sagehashi, T. Nara, S. Kanda, K. Numakura, M. Saito, T. Inoue, S. Satoh, and T. Habuchi

Subjects
Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published
2020
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22. qSR: a quantitative super-resolution analysis tool reveals the cell-cycle dependent organization of RNA Polymerase I in live human cells

Author

J. O. Andrews, W. Conway, W -K. Cho, A. Narayanan, J -H. Spille, N. Jayanth, T. Inoue, S. Mullen, J. Thaler, and I. I. Cissé

Subjects
Medicine, Science
Abstract

Abstract We present qSR, an analytical tool for the quantitative analysis of single molecule based super-resolution data. The software is created as an open-source platform integrating multiple algorithms for rigorous spatial and temporal characterizations of protein clusters in super-resolution data of living cells. First, we illustrate qSR using a sample live cell data of RNA Polymerase II (Pol II) as an example of highly dynamic sub-diffractive clusters. Then we utilize qSR to investigate the organization and dynamics of endogenous RNA Polymerase I (Pol I) in live human cells, throughout the cell cycle. Our analysis reveals a previously uncharacterized transient clustering of Pol I. Both stable and transient populations of Pol I clusters co-exist in individual living cells, and their relative fraction vary during cell cycle, in a manner correlating with global gene expression. Thus, qSR serves to facilitate the study of protein organization and dynamics with very high spatial and temporal resolutions directly in live cell.

Published
2018
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24. DISSEMINATION OF THE 'TOUCH THE UNIVERSE' TACTILE EXHIBITION

Author

K. Usuda-Sato, Y. Suzuki, S. Kawashima, Y. Goko, and T. Inoue

Subjects
General Medicine
Abstract

We created a whole set of the "Touch the Universe" tactile exhibition, including 3D models of celestial bodies and telescopes that both blind and visually impaired (BVI) people and sighted people can understand and enjoy. Through the JAPAN Science Museum Association network, science museums in Japan can easily borrow it and hold their own tacile exhibition without using a 3D printer. The exhibition set consists of existing 3D models, additional tactile images, scale models of the Solar System. Each model has a concise description panel with both printed and braille letters. This easy-to-use set can be a breakthrough for science museum staff members to hold their own tactile exhibition and communicate with BVI people.

Published
2022

25. Waterfall height sets the mechanism and rate of upstream retreat

Author

T. Inoue, N. Izumi, J.S. Scheingross, Y. Hiramatsu, S. Tanigawa, and T. Sumner

Subjects
Geology
Abstract

Waterfalls are among the fastest-eroding parts of river networks, but predicting natural waterfall retreat rates is difficult due to multiple processes that can drive waterfall erosion. We lack data on how waterfall height influences the mechanism and rate of upstream waterfall retreat. We addressed this knowledge gap with experiments testing the influence of drop height on waterfall retreat. Our experiments showed that shorter waterfalls retreat up to five times faster than taller waterfalls, when bedrock strength, sediment supply, and water discharge are constant. This retreat rate difference is due to a change in the erosion mechanism. Short waterfalls retreat by the formation of several small, rapidly eroding bedrock steps (i.e., cyclic steps), whereas tall waterfalls tend to form large bedrock plunge pools where lateral plunge pool erosion allows headwall undercutting and subsequent waterfall retreat. Because waterfall height can be partially set by the waterfall formation mechanism, our results highlight that the rate of waterfall retreat and subsequent landscape evolution can be modulated by the processes that form waterfalls.

Published
2023

26. KpFtsZ single filament

Author

J, Fujita, additional, H, Amesaka, additional, T, Yoshizawa, additional, K, Hibino, additional, N, Kamimura, additional, N, Kuroda, additional, T, Konishi, additional, Y, Kato, additional, M, Hara, additional, T, Inoue, additional, K, Namba, additional, SI, Tanaka, additional, and H, Matsumura, additional

Published
2023
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27. KpFtsZ–Mb double helical tube

Author

J, Fujita, additional, H, Amesaka, additional, T, Yoshizawa, additional, K, Hibino, additional, N, Kamimura, additional, N, Kuroda, additional, T, Konishi, additional, Y, Kato, additional, M, Hara, additional, T, Inoue, additional, K, Namba, additional, SI, Tanaka, additional, and H, Matsumura, additional

Published
2023
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29. Isoprothiolane advances improvement of color through gibberellic acid metabolism in satsuma mandarin (Citrus unshiu Marc.)

Author

Satoru Kondo, Hiroyuki Tomiyama, Risa Oda, Takanori Saito, Katsuya Ohkawa, Hitoshi Ohara, S Aramaki, T Inoue, and Takashi Ohtsuka

Subjects
Physiology, Plant Science, Agronomy and Crop Science
Abstract

The functions of isoprothiolane (IPT), which is a fungicide against rice blast, in carotenoid accumulation were examined in satsuma mandarin fruit (Citrus unshiu Marc). Whole trees were treated with IPT at 25 days before harvest. Concentrations of gibberellic acid-1 (GA1) and GA4 in the flavedo of IPT-treated trees were significantly decreased at 5 days after treatment (DAT) compared to the untreated control. The expressions of CitGA20ox1 in IPT-treated flavedo were lower than those in the untreated controls at 5 and 25 DAT. The CitGA3ox expressions in IPT-treated flavedo were lower than those in the untreated control at 5 DAT. ABA concentrations in IPT-treated flavedo were significantly higher than those in the untreated control at 25 DAT. The concentrations of b-cryptoxanthin in IPT-treated flavedo were higher than those in the untreated control at 25 DAT. The chlorophyll concentrations of IPT-treated flavedo were lower than those in the untreated control at 5 and 20 DAT. These results suggest that IPT advances b-cryptoxanthin accumulation through the regulation of endogenous GA1 and GA4 based on the inhibition of CitGA20ox1 and CitGA3ox expressions. It is possible that IPT can be utilized to improve coloration in other citrus fruit.

Published
2023

30. Random non-proportional fatigue tests with planar tri-axial fatigue testing machine

Author

T. Inoue, R. Nagao, and N. Takeda

Subjects
Fatigue, Non-proportional, Random, Plane stress, Fatigue life prediction, Testing machine, Mechanical engineering and machinery, TJ1-1570, Structural engineering (General), TA630-695
Abstract

Complex stresses, which occur on the mechanical surfaces of transport machinery in service, bring a drastic degradation in fatigue life. However, it is hard to reproduce such complex stress states for evaluating the fatigue life with conventional multiaxial fatigue machines. We have developed a fatigue testing machine that enables reproduction of such complex stresses. The testing machine can reproduce arbitrary in-plane stress states by applying three independent loads to the test specimen using actuators which apply loads in the 0, 45, and 90 degree directions. The reproduction was tested with complex stress data obtained from the actual operation of transport machinery. As a result, it was found that the reproduced stress corresponded to the measured stress with an error range of less than 10 %. Then, we made a comparison between measured fatigue lives under random non-proportional loading conditions and predicted fatigue lives. It was found that predicted fatigue lives with cr, stress on critical plane, were over a factor of 10 against measured fatigue lives. On the other hand, predicted fatigue lives with ma, stress in consideration of a non-proportional level evaluated by using amplitude and direction of principal stress, were within a factor of 3 against measured fatigue lives

Published
2016
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31. Concentrations, loads and yields of organic carbon from two tropical peat swamp forest streams in Riau Province, Sumatra, Indonesia

Author

H.M. Yupi, T. Inoue, J. Bathgate, and R. Putra

Subjects
carbon leaching, DOC, fluvial carbon, TOC, tropical peatland, Ecology, QH540-549.5
Abstract

Tropical peat swamp forest (PSF) stores large quantities of carbon. To estimate how much organic C is released from this type of landscape we determined organic carbon (C) concentrations, loads and yields in two contrasting watercourses draining from PSF in Riau Province, Sumatra (Indonesia). Meranti Ditch (MD) is an artificial watercourse whose small catchment (estimated area 4.8 km2) is in semi-intact condition, whereas Turip River (TR) has a large natural catchment (estimated area 458 km2) covered with fairly intact PSF where > 75 % of the original canopy trees remain. The organic C load (Gg C yr-1) of each watercourse was calculated by combining TOC concentration with water discharge rate to give organic C yield (g C m-2 yr-1). Dissolved organic carbon (DOC) was the dominant (95.0–99.8 %) component of total organic carbon (TOC) in the water. TOC concentration was 85–94 mg C L-1 in MD and 50–58 mg C L-1 in TR. The high concentration in MD was not surprising because this catchment had been disturbed by repeated phases of logging and a dense network of ditches was excavated ten years ago. The TOC loads were 0.23 Gg C yr-1 in MD and 14.0 Gg C yr-1 in TR. TOC yields (i.e. TOC fluxes through the fluvial system) were 41.6–55.5 g C m-2 yr-1 in MD and 26.2–34.9 g C m-2 yr-1 in TR.

Published
2016
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33. GroEL on Quantifoil grid

Author

J, Fujita, additional, F, Makino, additional, H, Asahara, additional, M, Moriguchi, additional, S, Kumano, additional, I, Anzai, additional, J, Kishikawa, additional, Y, Matsuura, additional, T, Kato, additional, K, Namba, additional, and T, Inoue, additional

Published
2022
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34. A Value-of-Information Framework for Personalizing the Timing of Surveillance Testing

Author

Charles J. Wolock, Aasthaa Bansal, David L. Veenstra, Anirban Basu, Lurdes Y. T. Inoue, and Patrick J. Heagerty

Subjects
medicine.medical_specialty, Dynamic prediction, business.industry, Cost-Benefit Analysis, Health Policy, Disease progression, Uncertainty, Article, Value of information, Neoplasms, Disease Progression, Humans, Biomarker (medicine), Medicine, Personalized medicine, business, Intensive care medicine, Biomarkers
Abstract

Background Patient surveillance using repeated biomarker measurements presents an opportunity to detect and treat disease progression early. Frequent surveillance testing using biomarkers is recommended and routinely conducted in several diseases, including cancer and diabetes. However, frequent testing involves tradeoffs. Although surveillance tests provide information about current disease status, the complications and costs of frequent tests may not be justified for patients who are at low risk of progression. Predictions based on patients’ earlier biomarker values may be used to inform decision making; however, predictions are uncertain, leading to decision uncertainty. Methods We propose the Personalized Risk-Adaptive Surveillance (PRAISE) framework, a novel method for embedding predictions into a value-of-information (VOI) framework to account for the cost of uncertainty over time and determine the time point at which collection of biomarker data would be most valuable. The proposed sequential decision-making framework is innovative in that it leverages the patient’s longitudinal history, considers individual benefits and harms, and allows for dynamic tailoring of surveillance intervals by considering the uncertainty in current information and estimating the probability that new information may change treatment decisions, as well as the impact of this change on patient outcomes. Results When applied to data from cystic fibrosis patients, PRAISE lowers costs by allowing some patients to skip a visit, compared to an “always test” strategy. It does so without compromising expected survival, by recommending less frequent testing among those who are unlikely to be treated at the skipped time point. Conclusions A VOI-based approach to patient monitoring is feasible and could be applied to several diseases to develop more cost-effective and personalized strategies for ongoing patient care. Highlights In many patient-monitoring settings, the complications and costs of frequent tests are not justified for patients who are at low risk of disease progression. Predictions based on patient history may be used to individualize the timing of patient visits based on evolving risk. We propose Personalized Risk-Adaptive Surveillance (PRAISE), a novel method for personalizing the timing of surveillance testing, where prediction modeling projects the disease trajectory and a value-of-information (VOI)–based pragmatic decision-theoretic framework quantifies patient- and time-specific benefit-harm tradeoffs. A VOI-based approach to patient monitoring could be applied to several diseases to develop more personalized and cost-effective strategies for ongoing patient care.

Published
2021

35. Rivaroxaban Monotherapy in Patients With Atrial Fibrillation After Coronary Stenting

Author

Tetsuya Matoba, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa, Yukihiro Koretsune, Takafumi Hiro, Tetsuya Sumiyoshi, Kazumi Kimura, Yoichiro Hashimoto, Teruyuki Hirano, Hiroyuki Daida, Yasushi Okada, Tsutomu Yamazaki, A. Nakamura, E. Tamiya, T. Yamamoto, S. Suetake, T. Noguchi, S. Nakamura, A. Matsumura, J. Kojima, S. Suwa, H. Yamaguchi, K. Kaikita, T. Yasu, A. Nakajima, T. Yamada, H. Arai, Y. Hata, T. Sakanashi, H. Tateishi, T. Nakayama, Y. Nozaki, M. Akao, Y. Okumura, M. Tokue, N. Kuroki, Y. Maruyama, T. Matoba, N. Hagiwara, H. Suzuki, Y. Nishida, M. Ajioka, K. Yumoto, S. Shimizu, T. Aoyama, H. Shimomura, T. Takeda, K. Oshiro, N. Sugishita, Y. Shibata, T. Otonari, H. Kihara, H. Ogawa, A. Ohno, M. Hazama, M. Shimizu, K. Tsukahara, S. Haruta, T. Wakeyama, T. Haruna, M. Ito, K. Fujii, N. Atsuchi, M. Sata, K. Kimura, N. Hasebe, Y. Kobayasi, K. Ohsato, K. Hironaga, Y. Naganuma, K. Anzaki, K. Oiwa, S. Okazaki, Y. Nakagawa, K. Tokuhiro, K. Tanaka, T. Momose, Y. Fukushima, R. Kametani, K. Kawamitsu, Y. Saito, S. Akashi, K. Kumagai, K. Eshima, T. Tobaru, T. Seo, K. Okuhara, K. Kozuma, Y. Ikari, T. Takahashi, I. Michishita, H. Fujikura, S. Momomura, Y. Yamamoto, K. Otomo, T. Matsubara, H. Tashiro, T. Inoue, M. Ishihara, I. Shiojima, E. Tachibana, J. Ako, K. Sumii, N. Yamamoto, N. Ohmura, T. Nakamura, Y. Morita, N. Takahashi, K. Watanabe, H. Fujinaga, M. Maruyama, T. Oka, T. Shirayama, T. Amano, K. Fukui, K. Ando, S. Oshima, S. Kagiyama, H. Teragawa, M. Yuge, S. Ono, T. Koga, K. Fujiu, M. Kuwabara, Y. Ohya, Y. Yumoto, N. Kuji, M. Ikemura, K. Kario, K. Chatani, K. Sato, H. Miyagi, M. Murakami, K. Saito, M. Hoshiga, S. Sato, N. Kubo, Y. Sakamoto, K. Ashida, H. Sakamoto, S. Murasaki, H. Uehara, T. Akasaka, Y. Ooba, S. Nakahara, Y. Hanaoka, T. Nishimiya, R. Tsunoda, Y. Onuma, S. Higuchi, A. Tani, A. Wada, M. Kato, H. Obata, Y. Higuchi, T. Endo, R. Katou, T. Matsunaga, T. Matsuoka, H. Noguchi, M. Usui, T. Hayashi, Y. Otsuji, T. Osaki, H. Zaizen, H. Yoshihara, K. Kadota, T. Hirose, T. Miyazawa, A. Mori, M. Takano, W. Shimizu, M. Wake, S. Oriso, M. Yoshiyama, S. Kakinoki, T. Nishioka, T. Ozaki, K. Nomoto, K. Seki, K. Kawai, Y. Ozaki, S. Miura, M. Kawasaki, R. Funada, K. Dote, T. Nagano, S. Okamoto, T. Kubo, Y. Murozono, T. Owada, T. Doke, T. Matsumura, M. Horiuchi, A. Takaishi, M. Yamamoto, H. Nakashima, M. Munemasa, Y. Sakata, N. Inoue, T. Ota, Y. Hamano, N. Abe, T. Tsubokura, M. Goto, I. Kubota, M. Yano, K. Umetani, T. Date, H. Morimoto, T. Noda, S. Goto, K. Hibi, A. Nakano, S. Hiramitsu, Y. Kihara, M. Sugi, N. Shiba, D. Izumi, T. Sato, S. Tayama, T. Matsui, A. Suzuki, K. Ajiki, M. Oishi, M. Kiryu, T. Ko, H. Ando, S. Miyazaki, T. Kinugawa, H. Otake, H. Kitaoka, Y. Hirata, S. Honda, M. Manita, Y. Ishii, H. Oka, Y. Nanba, M. Nishino, T. Sakamoto, T. Saito, H. Sakai, M. Ichikawa, S. Namiuchi, K. Inoue, N. Komiyama, Y. Akashi, Y. Nakamura, T. Komaru, T. Hosokawa, T. Chikamori, H. Tanaka, O. Arasaki, K. Aonuma, Y. Wakasa, T. Yoshizawa, T. Sugano, N. Yokota, A. Kakutani, T. Suzuki, Y. Abe, T. Kataoka, H. Okayama, H. Yokoi, K. Chin, K. Hasegawa, H. Tomita, H. Honzyo, H. Kawai, K. Yamamoto, Y. Morino, S. Tsujiyama, S. Hamasaki, Y. Niijima, Y. Mizuno, A. Maki, K. Tanabe, T. Murohara, S. Naomi, M. Arikawa, T. Kato, N. Matsumoto, T. Minamino, H. Sairenji, N. Miyamoto, H. Ito, Y. Matsuura, S. Hata, Y. Nakatsu, T. Onodera, M. Yoshimura, H. Amano, E. Tokutake, M. Kasao, M. Moriguchi, M. Tsuji, H. Yamamoto, Y. Yanbe, T. Iwasawa, M. Suzuki, and H. Mori

Subjects
Rivaroxaban, medicine.medical_specialty, business.industry, Unstable angina, medicine.medical_treatment, Percutaneous coronary intervention, Atrial fibrillation, medicine.disease, Thrombosis, Coronary artery disease, Internal medicine, medicine, Cardiology, cardiovascular diseases, Myocardial infarction, Cardiology and Cardiovascular Medicine, business, Stroke, medicine.drug
Abstract

Objectives The aim of this AFIRE (Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease) trial subgroup analysis was to examine rivaroxaban monotherapy benefits and their relation to the time between stenting and enrollment among patients after coronary stenting. Background Of 2,215 patients with atrial fibrillation and stable coronary artery disease in the AFIRE trial, rivaroxaban monotherapy was noninferior to rivaroxaban plus antiplatelet therapy (combination therapy) in terms of efficacy and superior for safety endpoints. However, thrombotic risk after antiplatelet therapy cessation remained a concern among 1,444 patients who had undergone coronary stenting >1 year before enrollment. Methods The benefits of rivaroxaban monotherapy in coronary stenting subgroups were assessed for efficacy (a composite of stroke, systemic embolism, myocardial infarction, unstable angina requiring revascularization, or death of any cause), safety (major bleeding defined according to International Society on Thrombosis and Haemostasis criteria), ischemic endpoints, net adverse clinical event, and time between stenting and enrollment. Results Efficacy and safety endpoints for monotherapy were superior to combination therapy, with HRs of 0.70 for efficacy (95% CI: 0.50-0.98; P = 0.036) and 0.55 for safety (95% CI: 0.33-0.92; P = 0.019). For ischemic endpoints, the HR was 0.82 (95% CI: 0.58-1.15; P = 0.240). The HR became smaller with longer time between stenting and enrollment (efficacy, P for interaction = 0.158; safety, P = 0.097). Conclusions In patients with atrial fibrillation after coronary stenting, the benefits of rivaroxaban monotherapy for efficacy and safety endpoints were consistent with those in the whole AFIRE trial population. The benefits became apparent with longer time between stenting and enrollment. (Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study [AFIRE]; UMIN000016612 , NCT02642419 )

Published
2021

40. Macro-roughness model of bedrock–alluvial river morphodynamics

Author

L. Zhang, G. Parker, C. P. Stark, T. Inoue, E. Viparelli, X. Fu, and N. Izumi

Subjects
Dynamic and structural geology, QE500-639.5
Abstract

The 1-D saltation–abrasion model of channel bedrock incision of Sklar and Dietrich (2004), in which the erosion rate is buffered by the surface area fraction of bedrock covered by alluvium, was a major advance over models that treat river erosion as a function of bed slope and drainage area. Their model is, however, limited because it calculates bed cover in terms of bedload sediment supply rather than local bedload transport. It implicitly assumes that as sediment supply from upstream changes, the transport rate adjusts instantaneously everywhere downstream to match. This assumption is not valid in general, and thus can give rise to unphysical consequences. Here we present a unified morphodynamic formulation of both channel incision and alluviation that specifically tracks the spatiotemporal variation in both bedload transport and alluvial thickness. It does so by relating the bedrock cover fraction to the ratio of alluvium thickness to bedrock macro-roughness, rather than to the ratio of bedload supply rate to capacity bedload transport. The new formulation (MRSAA) predicts waves of alluviation and rarification, in addition to bedrock erosion. Embedded in it are three physical processes: alluvial diffusion, fast downstream advection of alluvial disturbances, and slow upstream migration of incisional disturbances. Solutions of this formulation over a fixed bed are used to demonstrate the stripping of an initial alluvial cover, the emplacement of alluvial cover over an initially bare bed and the advection–diffusion of a sediment pulse over an alluvial bed. A solution for alluvial–incisional interaction in a channel with a basement undergoing net rock uplift shows how an impulsive increase in sediment supply can quickly and completely bury the bedrock under thick alluvium, thus blocking bedrock erosion. As the river responds to rock uplift or base level fall, the transition point separating an alluvial reach upstream from an alluvial–bedrock reach downstream migrates upstream in the form of a "hidden knickpoint". A tectonically more complex case of rock uplift subject to a localized zone of subsidence (graben) yields a steady-state solution that is not attainable with the original saltation–abrasion model. A solution for the case of bedrock–alluvial coevolution upstream of an alluviated river mouth illustrates how the bedrock surface can be progressively buried not far below the alluvium. Because the model tracks the spatiotemporal variation in both bedload transport and alluvial thickness, it is applicable to the study of the incisional response of a river subject to temporally varying sediment supply. It thus has the potential to capture the response of an alluvial–bedrock river to massive impulsive sediment inputs associated with landslides or debris flows.

Published
2015
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41. Application of a global nonhydrostatic model with a stretched-grid system to regional aerosol simulations around Japan

Author

D. Goto, T. Dai, M. Satoh, H. Tomita, J. Uchida, S. Misawa, T. Inoue, H. Tsuruta, K. Ueda, C. F. S. Ng, A. Takami, N. Sugimoto, A. Shimizu, T. Ohara, and T. Nakajima

Subjects
Geology, QE1-996.5
Abstract

An aerosol-coupled global nonhydrostatic model with a stretched-grid system has been developed. Circulations over the global and target domains are simulated with a single model, which includes fine meshes covering the target region to calculate meso-scale circulations. The stretched global model involves lower computational costs to simulate atmospheric aerosols with fine horizontal resolutions compared with a global uniform nonhydrostatic model, whereas it may require higher computational costs compared with the general regional models, because the stretched-grid system calculates inside and outside the target domain. As opposed to general regional models, the stretched-grid system requires neither a nesting technique nor lateral boundary conditions. In this study, we developed a new-type regional model for the simulation of aerosols over Japan, especially in the Kanto areas surrounding Tokyo, with a maximum horizontal resolution of approximately 10 km. This model usually reproduces temporal variations and their averages of the observed weather around Japan. This model generally reproduces monthly mean distributions of the observed sulfate and SO2 over East Asia, with high correlations (R > 0.6), but the underestimation of the simulated concentrations by 40% (sulfate) and 50% (SO2). Their underestimation of the simulated sulfate and SO2 concentrations over East Asia are strongly affected by their underestimation in China and possibly by the uncertainty of the simulated precipitation around Japan. In the Kanto area, this model succeeds in simulating the wind patterns and the diurnal transitions around the center of the Kanto area, although it is inadequate to simulate the wind patterns and the diurnal transitions at some sites located at the edge of the Kanto area and surrounded on three sides by mountains, e.g., Maebashi, mainly due to the insufficient horizontal resolution. This model also generally reproduces both diurnal and synoptic variations of the observed and/or a regional aerosol-transport model, WRF-CMAQ, simulated EC, sulfate, and SO2 concentrations in the Kanto area, especially with their high correlation (R > 0.5) at Komae/Tokyo. Although the aerosol module used in this study is relatively simplified compared to the general regional aerosol models, this study reveals that our proposed model with the stretched-grid system can be applicable for the regional aerosol simulation.

Published
2015
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44. P-185 The migration speed of nucleolar precursor bodies in pronuclei affects in vitro fertilization-derived human embryo ploidy status

Author

T Inoue, S Taguchi, M Uemura, Y Tsujimoto, and Y Yamashita

Subjects
Reproductive Medicine, Rehabilitation, Obstetrics and Gynecology
Abstract

Study question Does the migration speed of nucleolar precursor bodies (NPBs) in male and female pronuclei (mPN and fPN) affect in vitro fertilization (IVF)-derived embryo ploidy status? Summary answer The NPB migration speed in mPN impacts the IVF-derived human embryo ploidy status and this indicator could be an attractive marker for noninvasive embryo selection. What is known already NPBs are not considered as simple nucleolar components transmitted from an oocyte to an embryo, and they could participate in genome remodeling during embryo development. NPBs are essential only shortly after fertilization, suggesting that they may actively participate in centromeric chromatin establishment. A previous study demonstrated that NPBs migrated faster in intracytoplasmic sperm injection-derived zygotes having the potential to develop into a blastocyst and eventually into a baby (Inoue et al., 2021). However, the relationship between NPB migration speed and IVF-derived embryo ploidy status is unclear. Study design, size, duration The relationship between the NPB migration speed and embryo ploidy status was retrospectively analyzed in patients with recurrent assisted reproductive technology failure (euploid n =18; aneuploid n =19; and total = 219 NPBs). Archived time-lapse videos (images were recorded every 5 min; Geri+) from incubation after IVF were retrieved after the patients were identified for the study, and the NPB migration speed was analyzed. The retrospective analyses were performed with the patient’s identities masked. Participants/materials, setting, methods mPN and fPN were identified by appearance location in a zygote (fPN appearance is just below the polar bodies). The mPN, fPN, and 2–3 NPBs/PN central coordinates were measured by Kinovea (motion capture software). Their central coordinates were confirmed/revised every image and were decided. The migration distance of NPBs between two sequential images was calculated as the standard of the central PN coordinates. Thereafter, the migration speed of NPBs was calculated. Main results and the role of chance Both NPB speeds were significantly faster in the euploid than in the aneuploid groups (mPN: 4.08±0.61 vs. 3.54±0.54 µm/h, P =0.003, power [1-β]: 0.999, fPN: 4.03±0.89 vs. 3.26±0.45 µm/h, P Limitations, reasons for caution The NPB migration in the z-axis direction could not be analyzed. NPB tracking could not be performed when NPBs were large in number or drastically moved. Our findings should help in elucidating the relationship, although they did not completely explain the relationship between NPB migration and embryo development. Wider implications of the findings The migration speed of NPBs impacts human embryo ploidy status. NPB migration speed may add clinical value for embryo selection, which may be associated with live birth, and consequently, the time of the live birth could be shorter. The indicator could be an attractive marker for noninvasive embryo selection. Trial registration number Not applicable

Published
2022

45. Simplified Improvement of Higher Order Extended Bulk Flow Analysis Specialized for Derivation of Rotordynamic Coefficients of the Annular Plain Seal With Large Static Eccentricity

Author

T. Inoue and K. Yamada

Subjects
Control and Systems Engineering, Applied Mathematics, Mechanical Engineering, General Medicine
Abstract

Rotordynamic (RD) fluid force of turbomachinery is known as one of the causes of the shaft vibration problem. Bulk flow analysis is the analytical method of RD fluid force, and it is widely used in design stage. Conventional bulk flow analysis has been basically carried out under the assumption of concentric circular whirl orbit. While, the actual turbomachinery is often operated with static eccentricity due to the effect of static load and so on. However, there are not many studies that have investigated the case with large static eccentricity, in particular, the case more than half the seal clearance. In this paper, the linear RD coefficient for the plain annular seal is focused on and examined for the range that static eccentricity is up to 65% of seal clearance. In this range of static eccentricity, it requires the nonlinear analysis extended to the fifth order and largely increases the number of equations to be solved. This paper proposed simplification of higher order extended bulk flow (SHEBF) analysis, and as a result, the number of analytical equations to be solved is significantly reduced. The validity of this method is confirmed both numerically and experimentally.

Published
2022

46. Study on hydraulic resistance of erodible bed at the Chiyoda experimental flume

Author

T. Kakinuma, T. Inoue, R. Akahori, and A. Takeda

Subjects
Science, Geology, QE1-996.5, Dynamic and structural geology, QE500-639.5
Abstract

The authors made erodible bed experiments under steady flow condition at the Chiyoda Experimental Flume, a large-scale facility constructed on the floodplain of the Tokachi River, and observed sand waves on the bed of the flume. In this study, the characteristics of the sand waves are examined along the longitudinal survey lines and confirmed to be dunes. Next, the authors estimated Manning's roughness coefficients from the observed hydraulic values and assumed that the rise of the coefficients attributed to the sand wave development. Finally, vertical flow distribution on the sand waves are examined, and observed velocity distribution on the crest of waves found to be explained by the logarithmic distribution theory.

Published
2014
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47. Takayasu's Arteritis with Symptomatic Brachiocephalic Artery Stenosis and Left Common Carotid Artery Occlusion Undergoing Partial Arch Replacement after Coronary Artery Bypass Grafting

Author

Kenji Okada, Mari Hamaguchi, Soichiro Henmi, Hidekazu Nakai, Katsuhiro Yamanaka, Takeshi Inoue, Takanori Tsujimoto, Yu Murakami, Atsushi Omura, and T. Inoue

Subjects
medicine.medical_specialty, Bypass grafting, business.industry, Takayasu's arteritis, medicine.disease, Stenosis, medicine.anatomical_structure, Internal medicine, medicine.artery, Occlusion, medicine, Brachiocephalic artery, Cardiology, Common carotid artery, business, Artery
Published
2021

48. Gas exchange of root hemi-parasite Striga hermonthica and its host Sorghum bicolor under short-term soil water stress

Author

T. Inoue, Y. Yamauchi, A. H. Eltayeb, H. Samejima, A. G. T. Babiker, and Y. Sugimoto

Subjects
drought, host-parasite interaction, net photosynthetic rate, relative water content, respiration rate, stomatal conductance, transpiration rate, Biology (General), QH301-705.5, Plant ecology, QK900-989
Abstract

The gas exchange of the upper fully expanded leaf of the root parasite Striga hermonthica and of its host Sorghum bicolor was measured under wet and dry conditions to identify the mechanisms of the devastating effects of the parasite on its hosts under drought. The short-term water stress severely reduced photosynthetic rate in infected sorghum, but less in S. hermonthica. Soil water stress did not affect leaf respiration rate in either S. hermonthica or infected sorghum. This suggests that under dry conditions both infected sorghum and S. hermonthica decreased autotrophic carbon gain. The transpiration rate of S. hermonthica, a major driving force for assimilate uptake from the host, was higher and less affected by water stress than that of infected sorghum. Stomatal density on the abaxial surfaces of the leaves was higher in S. hermonthica than in sorghum. Both S. hermonthica infection and water stress decreased stomatal conductance of the sorghum leaves. S. hermonthica, irrespective of soil water status, had greater stomatal aperture on the adaxial and abaxial surfaces of its leaves than infected sorghum. These results indicate that the higher transpiration rate of S. hermonthica even under water stress, achieved through higher stomatal density on the abaxial surfaces of the leaves and greater stomatal aperture on both surfaces of the leaves, may induce the maintenance of water and solute transfers from the host to the parasite leading to severe damage to the host under drought.

Published
2013
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