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2. P1127: WATCHFUL WAITING IS AN ACCEPTABLE TREATMENT OPTION FOR PRIMARY OCULAR ADNEXAL MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA: A RETROSPECTIVE STUDY

Author

K. Mizuhara, T. Kobayashi, M. Nakao, R. Takahashi, H. Kaneko, K. Shimura, K. Hirakawa, N. Uoshima, Y. Kamitsuji, K. Wada, E. Kawata, R. Isa, T. Fujino, Y. Matsumura-Kimoto, T. Tsukamoto, S. Mizutani, Y. Shimura, M. Taniwaki, and J. Kuroda

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
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3. Incidence and Clinical Significance of Hyperkalemia Following Heart Transplantation

Author

Teruhiko Imamura, Luise Holzhauser, Matan Uriel, Gene Kim, Nir Uriel, T. Fujino, Laura Lourenco, Gabriel Sayer, Ann Nguyen, Jayant Raikhelkar, and Daniel Rodgers

Subjects
Adult, Male, medicine.medical_specialty, Hyperkalemia, medicine.medical_treatment, Gastroenterology, Postoperative Complications, Risk Factors, Internal medicine, medicine, Humans, Cumulative incidence, Clinical significance, Aged, Retrospective Studies, Heart transplantation, Transplantation, business.industry, Incidence, Incidence (epidemiology), Middle Aged, Confidence interval, Potassium, Heart Transplantation, Female, Surgery, medicine.symptom, Complication, business
Abstract

Background Hyperkalemia (HK) is a life-threatening complication following solid organ transplantation, and patients often need potassium-chelating agents and deviations from standard posttransplant protocols. This is the first study to report the incidence and clinical impact of hyperkalemia following heart transplantation. Methods We retrospectively included patients who underwent heart transplantation at our institution between April 2014 and December 2018. Patients with multiorgan transplantation were excluded. Clinical outcomes of patients who had serum potassium >5.5 mEq/L in the first year posttransplant (HK group) were compared to patients who did not have serum potassium >5.5 mEq/L in the first year posttransplant (non-HK group). Results A total of 143 patients were included in this study. During the first year posttransplant, cumulative incidence of serum potassium >5.0, >5.5, and >6.0 mEq/L was 96%, 63%, and 24%, respectively. Fifty-five percent of patients required treatment with potassium-chelating agents. Sulfamethoxazole-trimethoprim was discontinued because of HK in 39% of patients. Overall survival of patients in the HK group (n = 89) was comparable to that of patients in the non-HK group (n = 54, 91% vs 98% at 1 year, P = .19), whereas infection-free survival was significantly lower in the HK group (34% vs 53% at 1 year, P = .010). Multivariate analysis revealed pretransplant renal dysfunction (odds ratio = 2.62; 95% confidence interval, 1.18-5.80; P = .018) and use of mechanical circulatory support (odds ratio = 2.90; 95% confidence interval, 1.08-7.76; P = .035) as significant predictors of posttransplant hyperkalemia. Conclusions The incidence of HK following heart transplantation was high, with more than half of patients requiring any therapeutic interventions, and HK was related to an increase in infection events.

Published
2021
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6. Impact of worsening of aortic insufficiency during HeartMate 3 LVAD support

Author

D. Nitta, Nikhil Narang, Nir Uriel, Jonathan Grinstein, Jayant Raikhelkar, Takeyoshi Ota, Ann Nguyen, Daniel Rodgers, T. Fujino, Valluvan Jeevanandam, Gene Kim, Teruhiko Imamura, and Gabriel Sayer

Subjects
Adult, Male, Aortic valve, medicine.medical_specialty, Aortic Valve Insufficiency, 0206 medical engineering, Biomedical Engineering, Medicine (miscellaneous), Hemodynamics, Bioengineering, 02 engineering and technology, 030204 cardiovascular system & hematology, Doppler echocardiography, Patient Readmission, Ventricular Function, Left, Biomaterials, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Internal medicine, Humans, Medicine, Prospective Studies, Adverse effect, Proportional Hazards Models, Retrospective Studies, Heart Failure, Trauma Severity Indices, medicine.diagnostic_test, business.industry, Hazard ratio, General Medicine, Middle Aged, medicine.disease, 020601 biomedical engineering, Echocardiography, Doppler, Confidence interval, Treatment Outcome, medicine.anatomical_structure, Aortic Valve, Heart failure, Disease Progression, cardiovascular system, Cardiology, Female, Heart-Assist Devices, business, Follow-Up Studies, Destination therapy
Abstract

Aortic insufficiency remains a difficult to treat and highly morbid condition even in the era of HeartMate 3 left ventricular assist devices (LVADs). The prognostic nature of the longitudinal progression of aortic insufficiency, however, remains unknown. We prospectively collected data on patients who received HeartMate 3 LVAD implantation, who had assessments of aortic insufficiency using a novel Doppler echocardiography obtained at outflow graft at three (baseline) and 6 months postimplant. Patients with moderate or greater aortic insufficiency at baseline were excluded. The risk of aortic insufficiency progression on 1-year death and readmission for heart failure was investigated. In total, 41 patients (median 51 years old and 29 males) were included. All patients had less than moderate aortic insufficiency at baseline. Of them, 22 patients had worsening aortic insufficiency for 3 months following baseline assessments, which was associated with a significantly higher risk of 1-year death or heart failure readmission rate (41% vs. 11%, P = .023) with a hazard ratio of 3.24 (95% confidence interval 1.02-18.5, P = .038) adjusted for device speed at baseline and destination therapy indication. In patients with HeartMate 3 LVADs, progressive aortic insufficiency may be associated with a higher risk of 1-year death or readmission for heart failure. Close monitoring of patients with baseline aortic insufficiency should be considered as a measure to risk-stratify those for future adverse events.

Published
2020
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7. Future Perspectives of Intra-Aortic Balloon Pumping for Cardiogenic Shock

Author

T. Fujino, Teruhiko Imamura, and Koichiro Kinugawa

Subjects
medicine.medical_specialty, Intra-Aortic Balloon Pumping, business.industry, Cardiogenic shock, Shock, Cardiogenic, Diastole, General Medicine, Blood flow, 030204 cardiovascular system & hematology, medicine.disease, Balloon, 03 medical and health sciences, 0302 clinical medicine, Heart failure, Internal medicine, Circulatory system, medicine, Cardiology, Humans, 030212 general & internal medicine, Myocardial infarction, Cardiology and Cardiovascular Medicine, business
Abstract

An intra-aortic balloon pump (IABP) is a device of internal counterpulsation. Inflation of the balloon in diastole results in a potential increase in coronary blood flow and an improvement in systemic perfusion, and deflation at the end of diastole reduces left ventricular afterload, although the hemodynamic effects are relatively small. With its favorable safety profile due to fewer adverse events, IABP has been used for more than 5 decades as the most common mechanical circulatory support device for cardiogenic shock. Recently, however, other short-term devices have become available, and the position of IABP for cardiogenic shock is rapidly changing. Meanwhile, novel improvements in knowledge and technology are pushing the boundaries of this device. In this review, we summarize the basic physiology and current evidence of this device and then discuss the outlook and implications of IABP in the future.

Published
2020
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8. Estimation of the Severity of Aortic Insufficiency by HVAD Flow Waveform

Author

Teruhiko Imamura, Daniel Rodgers, Sara Kalantari, Gabriel Sayer, Tae Song, Nikhil Narang, Luise Holzhauser, Valluvan Jeevanandam, Ben Chung, Nir Uriel, Ann Nguyen, D. Nitta, Gene Kim, Takeyoshi Ota, T. Fujino, and Bryan Smith

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, Flow waveform, medicine.medical_specialty, Aortic Valve Insufficiency, 030204 cardiovascular system & hematology, Doppler echocardiography, Severity of Illness Index, Article, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Severity of illness, Humans, Medicine, Cutoff, In patient, Prospective Studies, Prospective cohort study, Aged, Framingham Risk Score, medicine.diagnostic_test, business.industry, Incidence, Middle Aged, Echocardiography, Doppler, 030228 respiratory system, Aortic Valve, Regurgitant fraction, Cardiology, Female, Surgery, Heart-Assist Devices, Illinois, Cardiology and Cardiovascular Medicine, business, Blood Flow Velocity
Abstract

Purpose Aortic insufficiency (AI) significantly affects morbidity and mortality in patients with left ventricular assist devices. Although AI may be commonly assessed by echocardiography, expert techniques are required for accurate quantification of AI severity. Description In this prospective blinded study, screenshots from the HVAD (Medtronic, Framingham, MA) display and simultaneous echocardiographic measurements were obtained. Each screenshot was digitized and the early diastolic phase slope was calculated, with blinding to the echocardiographic results. The regurgitant fraction of AI was quantified by Doppler echocardiography of the outflow graft. Evaluation A total of 30 patients (median, 57 years old; 57% male) were enrolled. A cutoff of −17.6 L/min/s for the early diastolic phase slope had a sensitivity of 0.92 and a specificity of 0.53 to estimate significant AI with a regurgitant fraction of 30% or greater, and it significantly stratified patients into a low regurgitant faction group (0.3%) and a high regurgitant fraction group (33.0%) (P = .009). The early diastolic phase slope had a moderate correlation with the actually measured regurgitant fraction (r = .50). Conclusions The early diastolic phase slope of the HVAD flow waveform may be a parameter that can estimate the presence of clinically significant AI.

Published
2020
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9. Short-Term Efficacy and Safety of Tolvaptan in Patients with Left Ventricular Assist Devices

Author

Teruhiko Imamura, Sara Kalantari, Daniel Rodgers, C. LaBuhn, Bryan Smith, T. Fujino, Jayant Raikhelkar, Nikhil Narang, Ben Chung, D. Nitta, Nir Uriel, Valluvan Jeevanandam, Nitasha Sarswat, Ann Nguyen, Gene Kim, and Gabriel Sayer

Subjects
Adult, Male, medicine.medical_specialty, Biomedical Engineering, Biophysics, Tolvaptan, Diuresis, Bioengineering, 030204 cardiovascular system & hematology, Article, Biomaterials, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Internal medicine, medicine, Humans, In patient, Retrospective Studies, Heart Failure, business.industry, Medical record, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, 030228 respiratory system, Heart failure, Cardiology, Female, Heart-Assist Devices, Hyponatremia, business, Antidiuretic Hormone Receptor Antagonists, medicine.drug
Abstract

Tolvaptan is an effective therapy for heart failure patients with symptomatic congestion and hyponatremia. The efficacy of its use in patients with continuous-flow left ventricular assist devices (LVADs) is unknown. The aim of this study was to assess the clinical efficacy and safety of tolvaptan in LVAD patients. We retrospectively reviewed medical records of patients who underwent LVAD implantation between January 2014 and August 2018. Among 217 consecutive LVAD patients, tolvaptan was used in 20 patients. Mean age was 46 ± 14 years old and 14 patients were males. The duration of tolvaptan therapy was 4 (interquartile range 1–8) days. Urine volume significantly increased from 2,623 ± 1,109 ml/day before tolvaptan to 4,308 ± 1,432 ml/day during tolvaptan therapy (p < 0.001). Serum sodium increased from 127 ± 3 to 133 ± 3 mEq/L at the end of tolvaptan therapy (p < 0.001). No patients developed hypernatremia (serum sodium >150 mEq/L). The 90-day overall survival following tolvaptan therapy was 89% in both the tolvaptan group and a propensity score-matched non-tolvaptan group (p = 0.918). Survival free of heart failure readmissions was also comparable between the groups (p = 0.751). In conclusion, short-term use of tolvaptan following LVAD implantation is a safe and effective therapy to augment diuresis and improve hyponatremia.

Published
2020
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10. Transcatheter Aortic Valve Replacement in Left Ventricular Assist Device Patients with Aortic Regurgitation

Author

Anthony J. Kanelidis, B.B. Chung, Mark N. Belkin, Takeyoshi Ota, Sara Kalantari, Luise Holzhauser, Gabriel Sayer, Ann Nguyen, Teruhiko Imamura, Nikhil Narang, Nir Uriel, Jayant Raikhelkar, Atman P. Shah, Valluvan Jeevanandam, John E.A. Blair, Daniel Burkhoff, Sandeep Nathan, T. Fujino, Jonathan Paul, Bryan Smith, Imo A. Ebong, and Gene Kim

Subjects
medicine.medical_specialty, Poor prognosis, Transcatheter aortic, business.industry, medicine.medical_treatment, Regurgitation (circulation), equipment and supplies, Valve replacement, Internal medicine, Ventricular assist device, cardiovascular system, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract

Background: Development of aortic regurgitation (AR) following left ventricular assist device (LVAD) implantation is common, and it is associated with a poor prognosis. Transcatheter aortic valve r...

Published
2020
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14. Experimental Study of $^{4}n$ by Directly Detecting the Decay Neutrons

Author

Atsumi Saito, Yohei Shimizu, H. Törnqvist, B. Monteagudo, T. Isobe, M. Caamaño, H. Scheit, S. Kiyotake, J. Tscheuschner, M. L. Cortés, F. M. Marqués, N. Fukuda, N. A. Orr, J. M. Gheller, A. Gillibert, A. Matta, K. Yoneda, L. Stuhl, Z. Elekes, I. Kuti, V. Wagner, M. Miwa, Z. Halász, A. Obertelli, S. Kim, A. Revel, L. Zanetti, N. L. Achouri, S. Takeuchi, F. Dufter, C. A. Douma, S. Masuoka, Stefanos Paschalis, R. Gernhäuser, S. Chen, Nobuyuki Chiga, S. Storck, T. Shimada, M.N. Harakeh, P. Koseoglou, T. Harada, B. Yang, M. Matsumoto, H. Takeda, D. S. Ahn, Yuya Kubota, H. Yamada, Yasuhiro Togano, A. Hirayama, Y. Yasuda, T. Fujino, D. M. Rossi, Nasser Kalantar-Nayestanaki, J. Tanaka, M. Böhmer, N. Inabe, Didier Beaumel, S. Park, Thomas Aumann, H. Baba, Tomohiro Uesaka, F. Schindler, J. Feng, Zaihong Yang, I. Murray, Julien Gibelin, K. Boretzky, S. W. Huang, B. Fernández-Domínguez, S. Reichert, Takashi Nakamura, Yu-xin Liu, K. Wimmer, Yukie Maeda, L. Yang, H. Sato, E. Tronchin, P. Doornenbal, Dmytro Symochko, D. Cortina, J. Kahlbow, S. Shimoura, H. Suzuki, Hideaki Otsu, M. Potlog, P. J. Li, J. Mayer, H. Miki, Masaki Sasano, Toshio Kobayashi, Z. Ge, D. Kim, Juzo Zenihiro, T. Tomai, I. Stefan, M. Parlog, H. Simon, V. Panin, Igor Gašparić, C. Lehr, Yosuke Kondo, C. Lenain, U. Forsberg, Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Research unit Nuclear & Hadron Physics, and Nuclear Energy

Subjects
Nuclear structure and force, tetraneutron, direct reactions, radioactive beams, Physics, Nuclear physics, 010308 nuclear & particles physics, 0103 physical sciences, Tetraneutron, Neutron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 010306 general physics, 01 natural sciences, Atomic and Molecular Physics, and Optics, 3. Good health
Abstract

The tetraneutron has attracted the attention of nuclear physicists during the past decades, but there is still no unambiguous confirmation of its existence or non-existence. A new experiment based on $$^{8}$$ He(p, 2p) $$^{7}$$ H{t+ $$^{4}n$$ } reaction, with direct detection of the four neutrons, has been carried out at RIBF, which can hopefully help to draw a definite conclusion on the tetraneutron system.

Published
2021
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15. Discordance between immunofluorescence and immunohistochemistry C4d staining and outcomes following heart transplantation

Author

Daniel Rodgers, Gene Kim, Yuto Kumai, Anthony Chang, Aliya N. Husain, Kammi J. Henriksen, T. Fujino, Nir Uriel, Gabriel Sayer, Sara Kalantari, and Benjamin Yang

Subjects
Graft Rejection, medicine.medical_specialty, medicine.medical_treatment, Biopsy, Fluorescent Antibody Technique, 030230 surgery, Immunofluorescence, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Complement C4b, Humans, Clinical significance, Cumulative incidence, Heart transplantation, Transplantation, medicine.diagnostic_test, Staining and Labeling, business.industry, medicine.disease, Immunohistochemistry, Peptide Fragments, Staining, Heart failure, Heart Transplantation, 030211 gastroenterology & hepatology, business
Abstract

BACKGROUND Capillary deposition of C4d is an important marker of antibody-mediated rejection (AMR) following heart transplantation (HT). There are two immunopathologic assay methods for detecting C4d: frozen-tissue immunofluorescence (IF) and paraffin immunohistochemistry (IHC). The clinical significance of discrepancy between the results of IF and IHC has not been understood. METHODS AND RESULTS We reviewed 2187 biopsies from 142 HT recipients who had biopsies with assessment of both IF and IHC staining. Among them, 103 (73%) patients had negative IF and IHC C4d staining (Negative Group) and 32 (23%) patients had positive IF but negative IHC staining (Discordant Group). At the time of positive biopsy, 6 (19%) Discordant patients had graft dysfunction, compared to 5 (5%) Negative patients (p = .022). Cumulative incidence of cellular rejection at 1 year was comparable (31% vs. 29%, p = .46); however, cumulative incidence of AMR was significantly higher in the Discordant group (21% vs. 4%, p = .004). Overall 1-year survival was comparable (90% vs. 96%, p = .24); however, freedom from heart failure (HF) was significantly lower in the Discordant group (70% vs. 96%, p

Published
2021

17. Prevalence of Epiretinal Membrane among Subjects in a Health Examination Program in Japan

Author

Shimizu H, Asaoka R, Omoto T, Fujino Y, Mitaki S, Onoda K, Nagai A, Yamaguchi S, Tanito M., Shimizu, Hiroshi, MITAKI, Shingo, NAGAI, Atsushi, Yamaguchi, Shuhei, TANITO, Masaki, Shimizu H, Asaoka R, Omoto T, Fujino Y, Mitaki S, Onoda K, Nagai A, Yamaguchi S, Tanito M., Shimizu, Hiroshi, MITAKI, Shingo, NAGAI, Atsushi, Yamaguchi, Shuhei, and TANITO, Masaki

Published
2021

19. Donor-derived cell-free DNA is associated with cardiac allograft vasculopathy

Author

Nir Uriel, Jayant Raikhelkar, Kevin J. Clerkin, Luise Holzhauser, T. Fujino, Gabriel Sayer, Francis J. Alenghat, and Gene Kim

Subjects
Graft Rejection, Angiogenesis, Inflammation, 030230 surgery, Cardiac allograft vasculopathy, Article, 03 medical and health sciences, 0302 clinical medicine, Medicine, Humans, Donor derived, Multiplex, Transplantation, biology, medicine.diagnostic_test, business.industry, Allografts, Kidney Transplantation, Tissue Donors, Cell-free fetal DNA, Immunoassay, Immunology, cardiovascular system, biology.protein, Heart Transplantation, 030211 gastroenterology & hepatology, Antibody, medicine.symptom, business, Cell-Free Nucleic Acids
Abstract

BACKGROUND: The role of donor-derived cell-free DNA (dd-cfDNA) in screening for cardiac allograft vasculopathy (CAV) is unknown. We hypothesized that dd-cfDNA correlates with CAV, markers of inflammation, and angiogenesis in stable heart transplant (HT) recipients. METHODS: Sixty-five HT recipients ≥2 years post-transplant, without recent rejection, were stratified by high (≥0.12%) versus low levels (

Published
2020

20. Hypogammaglobulinemia following heart transplantation: Prevalence, predictors, and clinical importance

Author

Gene Kim, Nir Uriel, Gabriel Sayer, Jayant Raikhelkar, Yuto Kumai, T. Fujino, Luise Holzhauser, Laura Lourenco, D. Nitta, Daniel Rodgers, and Ann Nguyen

Subjects
Male, medicine.medical_specialty, Multivariate analysis, medicine.medical_treatment, 030230 surgery, Gastroenterology, Hypogammaglobulinemia, 03 medical and health sciences, 0302 clinical medicine, Agammaglobulinemia, Risk Factors, Internal medicine, Prevalence, Overall survival, medicine, Humans, Retrospective Studies, Heart transplantation, Transplantation, business.industry, Incidence (epidemiology), Mean age, Middle Aged, medicine.disease, Immunoglobulin G, Heart Transplantation, Female, 030211 gastroenterology & hepatology, Solid organ transplantation, business
Abstract

Hypogammaglobulinemia (HGG) can occur following solid organ transplantation. However, there are limited data describing the prevalence, risk factors, and clinical outcomes associated with HGG following heart transplantation. We retrospectively reviewed data of 132 patients who had undergone heart transplantation at our institution between April 2014 and December 2018. We classified patients into three groups based on the lowest serum IgG level post-transplant: normal (≥700 mg/dL), mild HGG (≥450 and

Published
2020
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21. Optimal cannula positioning of HeartMate 3 left ventricular assist device

Author

Jayant Raikhelkar, Valluvan Jeevanandam, Nikhil Narang, Nir Uriel, Daniel Rodgers, Teruhiko Imamura, Gene Kim, D. Nitta, T. Fujino, Ann Nguyen, Takeyoshi Ota, and Gabriel Sayer

Subjects
Adult, Male, medicine.medical_specialty, Heart Ventricles, medicine.medical_treatment, 0206 medical engineering, Biomedical Engineering, Medicine (miscellaneous), Lumen (anatomy), Hemodynamics, Bioengineering, 02 engineering and technology, 030204 cardiovascular system & hematology, Patient Readmission, Ventricular Function, Left, Prosthesis Implantation, Biomaterials, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Cannula, Humans, Pulmonary wedge pressure, Aged, Retrospective Studies, Heart Failure, business.industry, Central venous pressure, General Medicine, Middle Aged, equipment and supplies, medicine.disease, 020601 biomedical engineering, Survival Rate, Treatment Outcome, Echocardiography, Ventricular assist device, Heart failure, Coronal plane, Cardiology, Female, Heart-Assist Devices, business
Abstract

Background Cannula position in HeartMate II and HeartWare left ventricular assist devices (LVADs) is associated with clinical outcome. This study aimed to investigate the clinical implication of the device positioning in HeartMate 3 LVAD cohort. Methods and results Consecutive patients who underwent HeartMate 3 LVAD implantation were followed for one year from index discharge. At index discharge, chest X-ray parameters were measured: (1) cannula coronal angle, (2) height of pump bottom, (3) cannula sagittal angle, and (4) cannula lumen area. The association of each measurement of cannula position with one-year clinical outcomes was investigated. Sixty-four HeartMate 3 LVAD patients (58 years old, 64% male) were enrolled. In the multivariable Cox regression model, the cannula coronal angle was a significant predictor of death or heart failure readmission (hazard ratio 1.27 [1.01-1.60], p = 0.045). Patients with a cannula coronal angle ≤28 degrees had lower central venous pressure (p = 0.030), lower pulmonary capillary wedge pressure (p = 0.027), and smaller left ventricular size (p = 0.019) compared to those with the angle >28 degrees. Right ventricular size and parameters of right ventricular function were also better in the narrow angle group, as was one-year cumulative incidence of death or heart failure readmission (10% vs. 50%, p = 0.008). Conclusion Narrow cannula coronal angle in patients with HeartMate 3 LVADs was associated with improved cardiac unloading and lower incidence of death or heart failure readmission. Larger studies to confirm the implication of optimal device positioning are warranted.

Published
2020
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22. Results of gravitational lensing and primordial gravitational waves from the POLARBEAR experiment

Author

Peter A. R. Ade, Davide Poletti, C. Verges, Shunsuke Adachi, Kam Arnold, Yuji Chinone, A. Suzuki, Yuto Minami, Chang Feng, J. Peloton, Nathan Whitehorn, Oliver Jeong, N. W. Halverson, Yuki Inoue, T. Hamada, Akito Kusaka, Y. Zhou, A. Zahn, A. Cukierman, M. Aguilar, Carole Tucker, D. Beck, Nicoletta Krachmalnicoff, Rolando Dünner, Brian Keating, Paul L. Richards, Stephen M. Feeney, J. C. Groh, Julian Borrill, C. Tsai, Joshua Montgomery, Darcy Barron, Theodore Kisner, R. Stompor, G. Hall, D. Boettger, Tucker Elleflot, Josquin Errard, Frederick Matsuda, L. N. Lowry, D. Leon, Takayuki Tomaru, Reijo Keskitalo, Benjamin Westbrook, M. Navaroli, D. Kaneko, K. Cheung, Osamu Tajima, A. T. P. Pham, Eric V. Linder, Giulio Fabbian, A. J. Gilbert, L. Howe, Neil Goeckner-Wald, H. El-Bouhargani, Max Silva-Feaver, Hans P. Paar, M. A. Dobbs, S. Takatori, Federico Bianchini, Colin Ross, Christian L. Reichardt, John Groh, Praween Siritanasak, Julien Carron, Tomotake Matsumura, T. Fujino, Y. Akiba, H. Nishino, G. Jaehnig, Giuseppe Puglisi, Charles A. Hill, D. Tanabe, Andrew H. Jaffe, Masashi Hazumi, Nicholas Galitzki, Blake D. Sherwin, S. Kikuchi, Carlo Baccigalupi, E. M. Leitch, S. Beckman, N. Katayama, Grant Teply, A. Ducout, Aashrita Mangu, M. LeJeune, Adrian T. Lee, Nathan Stebor, Masaya Hasegawa, S. Takakura, Y. Segawa, Scott Chapman, Kevin T. Crowley, Chinone, Y, Adachi, S, Ade, P, Aguilar, M, Akiba, Y, Arnold, K, Baccigalupi, C, Barron, D, Beck, D, Beckman, S, Bianchini, F, Boettger, D, Borrill, J, Elbouhargani, H, Carron, J, Chapman, S, Cheung, K, Crowley, K, Cukierman, A, Dunner, R, Dobbs, M, Ducout, A, Elleflot, T, Errard, J, Fabbian, G, Feeney, S, Feng, C, Fujino, T, Galitzki, N, Gilbert, A, Goeckner-Wald, N, Groh, J, Hall, G, Halverson, N, Hamada, T, Hasegawa, M, Hazumi, M, Hill, C, Howe, L, Inoue, Y, Jaehnig, G, Jaffe, A, Jeong, O, Lejeune, M, Kaneko, D, Katayama, N, Keating, B, Keskitalo, R, Kikuchi, S, Kisner, T, Krachmalnicoff, N, Kusaka, A, Lee, A, Leitch, E, Leon, D, Linder, E, Lowry, L, Mangu, A, Matsuda, F, Matsumura, T, Minami, Y, Montgomery, J, Navaroli, M, Nishino, H, Paar, H, Peloton, J, Pham, A, Poletti, D, Puglisi, G, Reichardt, C, Richards, P, Ross, C, Segawa, Y, Sherwin, B, Silva-Feaver, M, Siritanasak, P, Stebor, N, Stompor, R, Suzuki, A, Tajima, O, Takakura, S, Takatori, S, Tanabe, D, Teply, G, Tomaru, T, Tsai, C, Tucker, C, Verges, C, Westbrook, B, Whitehorn, N, Zahn, A, Zhou, Y, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), POLARBEAR, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)

Subjects
History, satellite: Planck, Cosmic microwave background, gravitational lensing, cosmic background radiation: polarization, detector: noise, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Gravity waves, power spectrum, 01 natural sciences, Education, Primary mirror, symbols.namesake, Settore FIS/05 - Astronomia e Astrofisica, gravitation: lens, Polarization, 0103 physical sciences, Planck, mirror, 010303 astronomy & astrophysics, Physics, COSMIC cancer database, 010308 nuclear & particles physics, Gravitational wave, Settore FIS/05, POLARBEAR experiment, Gravitational effects, gravitational radiation: primordial, Astrophysics::Instrumentation and Methods for Astrophysics, Polarization (waves), Galaxy, Computer Science Applications, Gravitational lens, B-mode, symbols, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], galaxy
Abstract

POLARBEAR is a Cosmic Microwave Background radiation (CMB) polarization experiment that is located in the Atacama Desert in Chile. The scientific goals of the experiment are to characterize the B-mode signal from gravitational lensing, as well as to search for B-mode signals created by primordial gravitational waves (PGWs). Polarbear started observations in 2012 and has published a series of results. These include the first measurement of a nonzero B-mode angular auto-power spectrum at sub-degree scales where the dominant signal is gravitational lensing of the CMB. In addition, we have achieved the first measurement of crosscorrelation between the lensing potential, which was reconstructed from the CMB polarization data alone by Polarbear, and the cosmic shear field from galaxy shapes by the Subaru Hyper Suprime-Cam (HSC) survey. In 2014, we installed a continuously rotating half-wave plate (CRHWP) at the focus of the primary mirror to search for PGWs and demonstrated the control of low-frequency noise. We have found that the low-frequency B-mode power in the combined dataset with the Planck high-frequency maps is consistent with Galactic dust foreground, thus placing an upper limit on the tensor-to-scalar ratio of r < 0.90 at the 95% confidence level after marginalizing over the foregrounds.

Published
2020
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23. Aortic Insufficiency During HeartMate 3 Left Ventricular Assist Device Support

Author

D. Nitta, T. Fujino, Takeyoshi Ota, Jonathan Grinstein, Valluvan Jeevanandam, Teruhiko Imamura, Nikhil Narang, Daniel Rodgers, Ann Nguyen, N. I.R. Uriel, Gabriel Sayer, and G. E.N.E. Kim

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Aortic Valve Insufficiency, Hemodynamics, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Retrospective Studies, Heart Failure, business.industry, Hazard ratio, equipment and supplies, medicine.disease, Cannula, Confidence interval, Echocardiography, Doppler, Echocardiography, Heart failure, Ventricular assist device, Child, Preschool, Cardiology, Female, Implant, Heart-Assist Devices, Cardiology and Cardiovascular Medicine, Complication, business
Abstract

Background Aortic insufficiency (AI) is associated with morbidity and mortality in patients with continuous-flow left ventricular assist devices (LVADs), whereas its impact on the HeartMate 3 LVAD cohorts remains uninvestigated. We aimed to investigate the clinical impact of AI on patients with HeartMate 3 LVADs. Methods and Results Consecutive 61 patients (median age 54 years; 67% male) implanted with HeartMate 3 LVAD between 2015 and 2019 were enrolled and underwent echocardiography at 3 months after LVAD implantation. AI severity was quantified by the novel Doppler echocardiographic method obtained at the outflow cannula and the calculated regurgitation fraction of 30% or greater (moderate or greater) was defined as significant. At 3 months after implant, 12 patients (20%) had significant AI. They had a higher incidence of death or heart failure readmissions compared with those without significant AI during a 1-year observational period (70% vs 24%, P = .003) with an adjusted hazard ratio of 2.76 (95% confidence interval 1.03–7.88). Conclusions In patients with HeartMate 3 LVAD support, significant AI remains both prevalent and a clinically significant downstream complication.

Published
2020

24. A measurement of the CMB E-mode angular power spectrum at subdegree scales from 670 square degrees of POLARBEAR data

Author

Osamu Tajima, T. Fujino, Andrew H. Jaffe, Scott Chapman, Eric V. Linder, S. Kikuchi, N. Katayama, D. Leon, Masashi Hazumi, Oliver Jeong, D. Tanabe, Grant Teply, Nicholas Galitzki, Tucker Elleflot, S. Takakura, Christian L. Reichardt, Praween Siritanasak, Josquin Errard, Akito Kusaka, Giulio Fabbian, John Groh, Brian Keating, Federico Bianchini, Ben Westbrook, M. A. O. Aguilar Faúndez, Shunsuke Adachi, Ted Kisner, K. Cheung, Adrian T. Lee, Y. Zhou, C. Tsai, Neil Goeckner-Wald, Frederick Matsuda, Tomotake Matsumura, D. Beck, Kam Arnold, Masaya Hasegawa, S. Takatori, Darcy Barron, Carlo Baccigalupi, L. N. Lowry, Davide Poletti, Clara Vergès, Kevin D. Crowley, G. Hall, M. Navaroli, Haruki Nishino, Yuto Minami, Haruaki Hirose, A. T. P. Pham, Chang Feng, Yuji Chinone, H. El Bouhargani, Y. Segawa, M. A. Dobbs, Daisuke Kaneko, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), APC - Cosmologie, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Polarbear, Adachi, S, Aguilar Faundez, M, Arnold, K, Baccigalupi, C, Barron, D, Beck, D, Bianchini, F, Chapman, S, Cheung, K, Chinone, Y, Crowley, K, Dobbs, M, El Bouhargani, H, Elleflot, T, Errard, J, Fabbian, G, Feng, C, Fujino, T, Galitzki, N, Goeckner-Wald, N, Groh, J, Hall, G, Hasegawa, M, Hazumi, M, Hirose, H, Jaffe, A, Jeong, O, Kaneko, D, Katayama, N, Keating, B, Kikuchi, S, Kisner, T, Kusaka, A, Lee, A, Leon, D, Linder, E, Lowry, L, Matsuda, F, Matsumura, T, Minami, Y, Navaroli, M, Nishino, H, Pham, A, Poletti, D, Reichardt, C, Segawa, Y, Siritanasak, P, Tajima, O, Takakura, S, Takatori, S, Tanabe, D, Teply, G, Tsai, C, Verges, C, Westbrook, B, Zhou, Y, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)

Subjects
cosmological model, 010504 meteorology & atmospheric sciences, Cosmic microwave background, cosmic background radiation: polarization, detector: noise, Astrophysics, cosmic background radiation, 01 natural sciences, Physical Chemistry, Atomic, expansion: multipole, Cosmology, Particle and Plasma Physics, Cosmic microwave background radiation, Big Bang nucleosynthesis, polarbear data, polarization: power spectrum, 010303 astronomy & astrophysics, helium: primordial, Physics, Hubble constant, symbols, astro-ph.CO, power spectrum: angular dependence, Astronomical and Space Sciences, Physical Chemistry (incl. Structural), Astrophysics - Cosmology and Nongalactic Astrophysics, satellite: Planck, Cosmology and Nongalactic Astrophysics (astro-ph.CO), nucleosynthesis: big bang, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Astronomy & Astrophysics, symbols.namesake, Settore FIS/05 - Astronomia e Astrofisica, statistical analysis, Nucleosynthesis, 0103 physical sciences, Nuclear, Planck, cosmic background radiation: power spectrum, 0105 earth and related environmental sciences, Spectral density, Molecular, Astronomy and Astrophysics, Abundance of the chemical elements, detector: sensitivity, Space and Planetary Science, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Hubble's law
Abstract

We report a measurement of the E-mode polarization power spectrum of the cosmic microwave background (CMB) using 150 GHz data taken from July 2014 to December 2016 with the POLARBEAR experiment. We reach an effective polarization map noise level of $32\,\mu\mathrm{K}$-$\mathrm{arcmin}$ across an observation area of 670 square degrees. We measure the EE power spectrum over the angular multipole range $500 \leq \ell, Comment: 15 pages, 5 figures, submitted to ApJ

Published
2020
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25. Experimental study of 4 n with 8He(p,2p) reaction

Author

M. Böhmer, Masaki Sasano, S. Reichert, Naohito Inabe, S. Chen, T. Shimada, M. Matsumoto, Susumu Shimoura, I. Stefan, J. Kahlbow, N. Kalantar-Nayestanaki, T. Harada, D. Symochko, István Kuti, S. W. Huang, D. Cortina, Tomohiro Uesaka, Z. Ge, N. L. Achouri, Yosuke Kondo, Hiroyuki Takeda, K. Yoneda, B. Fernández-Domínguez, U. Forsberg, Z. Elekes, Roman Gernhäuser, Y. Yasuda, H. Suzuki, Yohei Shimizu, D. Beaumel, D. Kim, C. A. Douma, Yukie Maeda, A. Hirayama, J. M. Gheller, Heiko Scheit, F. Dufter, T. Elidiano, Yasuhiro Togano, M. L. Cortés, M. Potlog, Nobuyuki Chiga, P. J. Li, Juzo Zenihiro, B. Yang, T. Isobe, M. Caamaño, Thomas Aumann, H. T. Törnqvsit, A. Gillibert, D. S. Ahn, F. Schindler, M.N. Harakeh, J. Feng, J. Tscheuschner, S. Kim, Atsumi Saito, L. Zanetti, P. Koseoglou, V. Wagner, M. Parlog, B. M. Godoy, N. Orr, Takashi Nakamura, Yu-xin Liu, J. Mayer, A. Obertelli, Yuya Kubota, Hideaki Otsu, S. Storck, S. Masuoka, K. Boretzky, Kathrin Wimmer, H. Miki, T. Tomai, F. M. Marqués, V. Panin, P. Doornenbal, Stefanos Paschalis, L. Yang, Satoshi Takeuchi, M. A. Knösel, Igor Gašparić, T. Kobayashi, C. Lehr, H. Yang, C. Lenain, M. Miwa, Z. Halász, A. Revel, H. Sato, T. Fujino, D. M. Rossi, H. Baba, S. Park, I. Murray, L. Stuhl, H. Yamada, J. Gibelin, J. Tanaka, Naoki Fukuda, RIKEN Nishina Center for Accelerator-Based Science, German Research Foundation, Federal Ministry of Education and Research (Germany), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
Physics, Paper, History, 010308 nuclear & particles physics, tetraneutron, nuclear force, proton knock-out, radioactive beams, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, Computer Science Applications, Education, ddc, Nuclear physics, 0103 physical sciences, Tetraneutron, Neutron, ddc:530, 010306 general physics
Abstract

7 pags., 3 figs. -- 27th International Nuclear Physics Conference (INPC2019), The tetraneutron has attracted the attention of nuclear physicists during the past decades, but there is still no unambiguous confirmation of its existence or nonexistence. A new experiment based on 8 He(p,2p)7H{t+4n} reaction, with direct detection of the four neutrons, has been carried out at RIBF, which can hopefully help to draw a definite conclusion on the tetraneutron system., We acknowledge the support of the RIBF accelerator staff and the BigRIPS team for providing the high-quality beam. Z. H. Yang acknowledges the financial support from the Foreign Postdoctoral Researcher program of RIKEN. T. Aumann acknowledges the support by DFG via SFB 1245. P. Koseoglou acknowledges the support from BMBF (NUSTAR.DA grant No.05P 15RDFN1).

Published
2020
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27. Optimal Cannula Positioning of Heart Mate 3 Left Ventricular Assist Device

Author

Daniel Rodgers, Luise Holzhauser, Jayant Raikhelkar, Anh Nguyen, Gabriel Sayer, Dan Burkhoff, Teruhiko Imamura, Nikhil Narang, Nir Uriel, D. Nitta, Valluvan Jeevanandam, Gene Kim, Takeyoshi Ota, T. Fujino, and Bow Chung

Subjects
Pulmonary and Respiratory Medicine, Transplantation, medicine.medical_specialty, business.industry, medicine.medical_treatment, Central venous pressure, Lumen (anatomy), equipment and supplies, medicine.disease, Cannula, Sagittal plane, medicine.anatomical_structure, Internal medicine, Ventricular assist device, Heart failure, Coronal plane, medicine, Cardiology, Surgery, Cardiology and Cardiovascular Medicine, Pulmonary wedge pressure, business
Abstract

Purpose Cannula position in HeartMate II and HVAD left ventricular assist devices (LVADs) is associated with clinical outcome. We aimed to investigate the clinical implication of the device positioning in HeartMate 3 LVADs. Methods Consecutive patients who underwent HeartMate 3 LVAD implantation were followed for one year from index discharge. At index discharge, chest X-ray parameters were measured: (1) cannula coronal angle, (2) height of pump bottom, (3) cannula sagittal angle, and (4) cannula lumen area. Results Sixty-four HeartMate 3 LVAD patients (58 years old, 64% male) were enrolled. In the multivariate Cox regression model, cannula coronal angle was a significant predictor of heart failure readmission (hazard ratio 1.27 [1.01-1.60], p = 0.045). Patients with a cannula coronal angle ≤28 degrees had lower central venous pressure (p = 0.030), lower pulmonary capillary wedge pressure (p = 0.027), and smaller left ventricular size (p = 0.019) compared to those with the angle >28 degrees. Right ventricular size and parameters of right ventricular function were also better in the narrow angle group, as was survival free of heart failure readmission (90% vs. 50%, p = 0.008; Figure). Conclusion Narrow cannula coronal angle in patients with HeartMate 3 LVADs was associated with improved cardiac unloading and higher survival free of heart failure readmission. Further studies to clarify the methodology and implication of optimal device positioning are warranted.

Published
2020
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28. Post-Heart Transplant Diabetes Mellitus: Incidence, Prevalence and Outcomes

Author

Jayant Raikhelkar, Bow Chung, T. Fujino, Nir Uriel, Gabriel Sayer, Bryan Smith, S. Mazzone, Anh Nguyen, and Gene Kim

Subjects
0301 basic medicine, Pulmonary and Respiratory Medicine, Heart transplantation, Transplantation, medicine.medical_specialty, business.industry, Incidence (epidemiology), Insulin, medicine.medical_treatment, Renal function, 030209 endocrinology & metabolism, Retrospective cohort study, medicine.disease, Gastroenterology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Diabetes mellitus, Internal medicine, Medicine, Surgery, Cumulative incidence, Cardiology and Cardiovascular Medicine, Complication, business
Abstract

Purpose De novo diabetes mellitus (DM) is a common complication of solid organ transplantation. However, studies about post-transplant DM (PTDM) following heart transplantation (HT) are scarce. This study aims to compare baseline characteristics and clinical outcomes between patients who developed PTDM and those who did not as well as investigate the incidence and prevalence of PTDM following HT. Methods 148 consecutive patients undergoing HT between 4/2014 and 12/2018 were enrolled to this retrospective study. PTDM diagnosis was made based on a HbA1c ≥6.5%, fasting blood glucose ≥ 126mg/dL or use of insulin or oral hypoglycemic agents. Results Of the 148 patients, 57 (39%) had no DM, 37 (25%) had DM prior to HT, and 54 (36%) developed PTDM. Among the patients without DM at the time of HT, cumulative incidence of PTDM was 37% at discharge, 46% at 6 months, and 48% at 1 year post-HT. The prevalence of PTDM at 6 months post-HT was 44% and decreased to 36%, 26%, and 17% at 1, 2, and 3 years, respectively (Figure 1A). PTDM patients had a significantly higher pre-HT HbA1c compared to those without DM (5.8 (5.6, 6.0) vs 5.5 (5.3, 5.9)%; p=0.017). There was no difference in the dose of immunosuppressive medications between the groups. PTDM patients had a higher rate of infection requiring hospitalization compared to patients with no DM post-HT (80% vs 61%; p=0.036). Infection free survival was significantly lower in the PTDM group at 2 years (16% vs 35%; p=0.046) (Figure 1B). Overall survival (96% vs 96% at 2 years; p=0.986), rejection-free survival (46% vs 51% at 2 years; p=0.410), rate of cardiac allograft vasculopathy (33% vs 22%; p=0.267), kidney function and number of hospitalizations were similar between the PTDM and no DM groups. Conclusion The incidence of PTDM after HT was high but prevalence decreased after 6 months. Patients with PTDM had increased pre-HT HbA1c and higher post-HT rates of infection compared to patients without DM. Further studies are needed to determine the clinical impact of PTDM.

Published
2020
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29. Internal delensing of cosmic microwave background polarization B-modes with the POLARBEAR experiment

Author

Kam Arnold, Grant Teply, D. Leon, R. Stompor, Neil Goeckner-Wald, Yuji Chinone, D. Beck, J. Borrill, H. El Bouhargani, Kevin T. Crowley, S. Takatori, Toshiya Namikawa, M. A. O. Aguilar Faúndez, Max Silva-Feaver, M. Navaroli, Christian L. Reichardt, J. Peloton, Tucker Elleflot, Josquin Errard, Darcy Barron, Davide Poletti, Osamu Tajima, K. Cheung, C. Verges, L. N. Lowry, N. Katayama, Federico Bianchini, Eric V. Linder, Giulio Fabbian, Praween Siritanasak, Yuto Minami, Brian Keating, Julien Carron, L. Howe, Shunsuke Adachi, Tomotake Matsumura, A. T. P. Pham, Y. Segawa, Carlo Baccigalupi, Aamir Ali, Akito Kusaka, Masaya Hasegawa, Frederick Matsuda, Aaron Lee, Chang Feng, Giuseppe Puglisi, Charles A. Hill, T. Fujino, Y. Akiba, D. Tanabe, S. Kikuchi, H. Nishino, Masashi Hazumi, Blake D. Sherwin, AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), POLARBEAR, Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Adachi, S, Aguilar Faundez, M, Akiba, Y, Ali, A, Arnold, K, Baccigalupi, C, Barron, D, Beck, D, Bianchini, F, Borrill, J, Carron, J, Cheung, K, Chinone, Y, Crowley, K, El Bouhargani, H, Elleflot, T, Errard, J, Fabbian, G, Feng, C, Fujino, T, Goeckner-Wald, N, Hasegawa, M, Hazumi, M, Hill, C, Howe, L, Katayama, N, Keating, B, Kikuchi, S, Kusaka, A, Lee, A, Leon, D, Linder, E, Lowry, L, Matsuda, F, Matsumura, T, Minami, Y, Namikawa, T, Navaroli, M, Nishino, H, Peloton, J, Pham, A, Poletti, D, Puglisi, G, Reichardt, C, Segawa, Y, Sherwin, B, Silva-Feaver, M, Siritanasak, P, Stompor, R, Tajima, O, Takatori, S, Tanabe, D, Teply, G, Verges, C, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), APC - Cosmologie, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Cosmology and Nongalactic Astrophysics (astro-ph.CO), Cosmic Microwave Background Polarization, Cosmic microwave background, FOS: Physical sciences, General Physics and Astronomy, cosmic background radiation: polarization, General Relativity and Quantum Cosmology (gr-qc), Gravitation and Astrophysics, 01 natural sciences, General Relativity and Quantum Cosmology, B-mode: primordial, Settore FIS/05 - Astronomia e Astrofisica, QB0980, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), QC, QB, Physics, Settore FIS/05, Polarization (waves), inflation: model, Computational physics, POLARBEAR Experiment, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Instrumentation and Methods for Astrophysics, Variance reduction, Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Using only cosmic microwave background polarization data from the POLARBEAR experiment, we measure $B$-mode polarization delensing on subdegree scales at more than $5\sigma$ significance. We achieve a 14% $B$-mode power variance reduction, the highest to date for internal delensing, and improve this result to 2% by applying for the first time an iterative maximum a posteriori delensing method. Our analysis demonstrates the capability of internal delensing as a means of improving constraints on inflationary models, paving the way for the optimal analysis of next-generation primordial $B$-mode experiments., Comment: Matches version published in Physical Review Letters

Published
2019
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30. A Measurement of the Degree Scale CMB B-mode Angular Power Spectrum with POLARBEAR

Author

Julien Carron, M. A. Dobbs, C. Tsai, Dominic Beck, D. Leon, Ted Kisner, Aashrita Mangu, D. Boettger, Christian L. Reichardt, A. T. P. Pham, Kam Arnold, Akito Kusaka, Nicoletta Krachmalnicoff, T. Hamada, John Groh, S. Beckman, Josquin Errard, Ben Westbrook, Nathan Stebor, Neil Goeckner-Wald, Reijo Keskitalo, Daisuke Kaneko, Greg Jaehnig, Kevin T. Crowley, S. Takatori, Masaya Hasegawa, D. Tanabe, Tucker Elleflot, Giulio Fabbian, L. Howe, A. Cukierman, T. Fujino, Y. Zhou, S. Takakura, Eric V. Linder, Julian Borrill, N. Katayama, Yuki Inoue, Davide Poletti, Praween Siritanasak, Haruki Nishino, Yuto Minami, Yuji Chinone, Y. Segawa, H. El Bouhargani, Osamu Tajima, Aritoki Suzuki, N. W. Halverson, Darcy Barron, Masashi Hazumi, L. N. Lowry, G. Hall, Frederick Matsuda, Federico Bianchini, Scott Chapman, M. Navaroli, R. Stompor, Nicholas Galitzki, Clara Vergès, Maximiliano Silva-Feaver, Oliver Jeong, M. A. O. Aguilar Faúndez, Grant Teply, Brian Keating, Shunsuke Adachi, S. Kikuchi, K. Cheung, Adrian T. Lee, Giuseppe Puglisi, Charles A. Hill, Chang Feng, C. Baccigalupi, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), POLARBEAR, Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Adachi, S, Aguilar Faundez, M, Arnold, K, Baccigalupi, C, Barron, D, Beck, D, Beckman, S, Bianchini, F, Boettger, D, Borrill, J, Carron, J, Chapman, S, Cheung, K, Chinone, Y, Crowley, K, Cukierman, A, Dobbs, M, Bouhargani, H, Elleflot, T, Errard, J, Fabbian, G, Feng, C, Fujino, T, Galitzki, N, Goeckner-Wald, N, Groh, J, Hall, G, Halverson, N, Hamada, T, Hasegawa, M, Hazumi, M, Hill, C, Howe, L, Inoue, Y, Jaehnig, G, Jeong, O, Kaneko, D, Katayama, N, Keating, B, Keskitalo, R, Kikuchi, S, Kisner, T, Krachmalnicoff, N, Kusaka, A, Lee, A, Leon, D, Linder, E, Lowry, L, Mangu, A, Matsuda, F, Minami, Y, Navaroli, M, Nishino, H, Pham, A, Poletti, D, Puglisi, G, Reichardt, C, Segawa, Y, Silva-Feaver, M, Siritanasak, P, Stebor, N, Stompor, R, Suzuki, A, Tajima, O, Takakura, S, Takatori, S, Tanabe, D, Teply, G, Tsai, C, Verges, C, Westbrook, B, Zhou, Y, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), APC - Cosmologie, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Cosmic microwave background radiation, Cosmic inflation, Cosmology, Observational cosmology, cosmological model, 010504 meteorology & atmospheric sciences, Cosmic microwave background, Astrophysics, 01 natural sciences, Atomic, Physical Chemistry, Spectral line, thermal, Cosmic microwave background radiationCosmic inflationCosmologyObservational cosmology, Particle and Plasma Physics, polarization: power spectrum, 010303 astronomy & astrophysics, media_common, Physics, Settore FIS/05, Polarization (waves), symbols, astro-ph.CO, power spectrum: angular dependence, Astronomical and Space Sciences, Physical Chemistry (incl. Structural), Astrophysics - Cosmology and Nongalactic Astrophysics, data analysis method, noise, Cosmology and Nongalactic Astrophysics (astro-ph.CO), satellite: Planck, media_common.quotation_subject, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Astronomy & Astrophysics, frequency: high, cosmic background radiation: B-mode, symbols.namesake, Settore FIS/05 - Astronomia e Astrofisica, gravitation: lens, statistical analysis, 0103 physical sciences, Nuclear, Planck, cosmic background radiation: power spectrum, inflation, 0105 earth and related environmental sciences, gravitational radiation: primordial, gravitational radiation, Spectral density, Molecular, Astronomy and Astrophysics, Square degree, detector: sensitivity, Space and Planetary Science, Sky, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

We present a measurement of the $B$-mode polarization power spectrum of the cosmic microwave background (CMB) using taken from July 2014 to December 2016 with the POLARBEAR experiment. The CMB power spectra are measured using observations at 150 GHz with an instantaneous array sensitivity of $\mathrm{NET}_\mathrm{array}=23\, \mu \mathrm{K} \sqrt{\mathrm{s}}$ on a 670 square degree patch of sky centered at (RA, Dec)=($+0^\mathrm{h}12^\mathrm{m}0^\mathrm{s},-59^\circ18^\prime$). A continuously rotating half-wave plate is used to modulate polarization and to suppress low-frequency noise. We achieve $32\,\mu\mathrm{K}$-$\mathrm{arcmin}$ effective polarization map noise with a knee in sensitivity of $\ell = 90$, where the inflationary gravitational wave signal is expected to peak. The measured $B$-mode power spectrum is consistent with a $\Lambda$CDM lensing and single dust component foreground model over a range of multipoles $50 \leq \ell \leq 600$. The data disfavor zero $C_\ell^{BB}$ at $2.2\sigma$ using this $\ell$ range of POLARBEAR data alone. We cross-correlate our data with Planck high frequency maps and find the low-$\ell$ $B$-mode power in the combined dataset to be consistent with thermal dust emission. We place an upper limit on the tensor-to-scalar ratio $r < 0.90$ at 95% confidence level after marginalizing over foregrounds.

Published
2019
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31. Increasing heart transplant donor pool by liberalization of size matching

Author

Valluvan Jeevanandam, Jayant Raikhelkar, Nikhil Narang, Tae Song, Teruhiko Imamura, Luise Holzhauser, T. Fujino, D. Nitta, David Onsager, Anthony J. Kanelidis, Nir Uriel, Gene Kim, Nikhil Bassi, C. Murks, Gabriel Sayer, and Takeyoshi Ota

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, medicine.medical_specialty, Time Factors, Tissue and Organ Procurement, medicine.medical_treatment, Diastole, Cardiac index, Hemodynamics, 030204 cardiovascular system & hematology, 030230 surgery, Article, Donor Selection, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Donor pool, Retrospective Studies, Heart transplantation, Transplantation, business.industry, Heart, Organ Size, Length of Stay, Middle Aged, Size matching, Survival Rate, Size mismatch, Cohort, Cardiology, Heart Transplantation, Surgery, Female, Cardiology and Cardiovascular Medicine, business
Abstract

BACKGROUND: The heart transplant (HT) guidelines recommendation to match recipient and donors within 30% of body weight lacks a strong evidence base and is not well established in patients bridged to transplant with left ventricular assist devices (LVAD). In light of the scarcity of donor hearts, we investigated the effect of size mismatch on hemodynamics, one-year survival and length of stay (LOS) following HT. METHODS: Single-center retrospective analysis of consecutive HT patients from April 2007 to September 2017. Recipients were divided into 3 cohorts based on donor-to-recipient weight ratio (DRWR): (1) undersized (1.3). RESULTS: 288 consecutive patients were identified (mean age 53 ± 11 years; 76% male), 46 were undersized (0.61 ± 0.05), 210 size-matched (0.94 ± 0.16), and 32 oversized (1.65 ± 0.38). There was no significant difference in donor left ventricular end diastolic diameter (LVEDD) between the 3 groups (p = 0.11). The donor/recipient (D/R) predicted heart mass (PHM) was lowest in the undersized group (0.92 ± 0.13). There were no significant differences in 1-year survival in the overall and LVAD cohort (p = 0.65 and 0.59, respectively). Neither donor LVEDD nor D/R PHM differed among survivors or non-survivors. LOS was longer in the undersized group than the size-matched cohort (p = 0.004). The undersized group had hearts with the highest filling pressures and lowest cardiac index at 1 week among the remaining groups (p = 0.009, 0.017, and p = 0.05, respectively). There were no clinically significant differences in hemodynamics at 1 or 6 months. CONCLUSIONS: HT undersizing affects hemodynamics early but not later in the course and does not impact 1-year survival. The liberalization of size matching may increase the HT donor pool significantly.

Published
2019

32. Aortic Insufficiency and Hemocompatibility-related Adverse Events in Patients with Left Ventricular Assist Devices

Author

Bryan Smith, Gene Kim, Nikhil Narang, T. Fujino, Teruhiko Imamura, D. Nitta, Nir Uriel, Valluvan Jeevanandam, Takeyoshi Ota, Sara Kalantari, Ann Nguyen, Tae Song, Luise Holzhauser, Daniel Rodgers, Jonathan Grinstein, Colleen Juricek, and Gabriel Sayer

Subjects
Male, medicine.medical_specialty, Aortic Valve Insufficiency, Diastole, Hemodynamics, Regurgitation (circulation), 030204 cardiovascular system & hematology, Doppler echocardiography, Severity of Illness Index, Article, Ventricular Function, Left, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Materials Testing, medicine, Humans, 030212 general & internal medicine, Adverse effect, Retrospective Studies, Heart Failure, medicine.diagnostic_test, business.industry, Hemodynamic Monitoring, Atrial fibrillation, Middle Aged, medicine.disease, Cannula, Echocardiography, Doppler, United States, Heart failure, Cardiology, Female, Heart-Assist Devices, Cardiology and Cardiovascular Medicine, business
Abstract

AIM: Hemocompatibility-related adverse events (HRAE) are a major cause of readmissions in patients with left ventricular assist devices (LVAD). The impact of aortic insufficiency (AI) on HRAE remains uncertain. We aimed to investigate the impact of AI on HRAE. METHODS AND RESULTS: Patients who underwent LVAD implantation between August 2014 and July 2017 and had echocardiograms 3 months post-LVAD implantation were enrolled. AI severity was assessed by measuring the systolic/diastolic ratio of flow and the rate of diastolic flow acceleration using Doppler echocardiography of the outflow cannula. Regurgitation fraction was derived from these parameters. Significant AI was defined as regurgitation fraction > 30%. Among 105 patients (median age, 56 years; 76% male), 36 patients (34%) had significant AI. Baseline characteristics were statistically not significantly different between those with and without significant AI except for higher rates of ischemic etiology and atrial fibrillation in the significant AI group (P < 0.05 for both). One-year survival free from HRAE was 44% in patients with AI compared to 67% in patients without significant AI (P = 0.018). The average hemocompatibility score, which defines the net burden of HRAE, was higher in the AI group (1.72 vs 0.64; P = 0.009), due mostly to higher tier I (mild HRAE; P = 0.034) and tier IIIB scores (severe HRAE; P = 0.011). CONCLUSION: Significant AI, as assessed by Doppler echocardiographic parameters, was associated with HRAE during LVAD support. (J Cardiac Fail 2019;00:1–8)

Published
2019

33. HVAD Flow Waveform Estimates Left Ventricular Filling Pressure

Author

Gabriel Sayer, T. Fujino, Nikhil Narang, Nir Uriel, Gene Kim, Jonathan Grinstein, Daniel Rodgers, Valluvan Jeevanandam, Ann Nguyen, D. Nitta, and Teruhiko Imamura

Subjects
Flow waveform, Male, medicine.medical_specialty, medicine.medical_treatment, Heart Ventricles, Hemodynamics, Invasive hemodynamics, 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Cutoff, Humans, 030212 general & internal medicine, Prospective Studies, Pulmonary Wedge Pressure, Pulmonary wedge pressure, Heart Failure, business.industry, Middle Aged, medicine.disease, Heart failure, Ventricular assist device, Cardiology, Female, Heart-Assist Devices, Cardiology and Cardiovascular Medicine, business, Ventricular filling
Abstract

BACKGROUND: HVAD left ventricular assist device flow waveforms provides graphical real-time information linking device performance with invasive hemodynamics. Previous studies have demonstrated a good correlation between the slopes of the ventricular filling phase slope (VFPS) and directly measured pulmonary capillary wedge pressure (PCWP). We aimed to validate the utility of VFPS to estimate PCWP and predict clinical outcomes. METHODS: In this prospective blinded study, screenshots from the HVAD monitor and simultaneous invasive hemodynamic measurements were obtained. Each screenshot was digitized and the VFPS was calculated by 2 independent reviewers who were blinded to the hemodynamic results. The equation PCWP = 7.053 +1.365 × (VFPS) was derived from a previously published dataset and the estimated PCWP was correlated to the actually measured PCWP. RESULTS: One hundred thirty-one sets of simultaneous measurements (VFPS and PCWP) were obtained from 27 HVAD patients (mean age 55 years, 47% male). A previously proposed cutoff of VFPS ≥5.8 L/min/s predicted PCWP ≥18 mmHg with 91.5% sensitivity and 95.2% specificity with the area under curve of 0.987. The estimated PCWP significantly correlated with measured PCWP (R(2) = 0.65, P < .001) and showed acceptable agreement with measured PCWP. Patients with VFPS ≥5.8 L/min/s experienced significantly higher heart failure readmission rates than those without (0.24 vs 0.05 events/y, P < .001). CONCLUSIONS: VFPS of the HVAD flow waveform is a novel noninvasive parameter that can estimate PCWP. (J Cardiac Fail 2020;00:1 7)

Published
2019

34. Longitudinal Trajectories of Hemodynamics Following Left Ventricular Assist Device Implantation

Author

T. Fujino, Valluvan Jeevanandam, Nir Uriel, Gabriel Sayer, Daniel Burkhoff, Jayant Raikhelkar, Nikhil Narang, D. Nitta, Bryan Smith, Teruhiko Imamura, Aline Sayer, Ann Nguyen, C. LaBuhn, Daniel Rodgers, and Gene Kim

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Ventricular Dysfunction, Right, Cardiac index, Hemodynamics, 030204 cardiovascular system & hematology, Pulsatility index, 03 medical and health sciences, 0302 clinical medicine, medicine.artery, Internal medicine, Medicine, Humans, 030212 general & internal medicine, Pulmonary wedge pressure, Retrospective Studies, Heart Failure, business.industry, Central venous pressure, Middle Aged, medicine.disease, Heart failure, Ventricular assist device, Pulmonary artery, Cardiology, Heart-Assist Devices, Cardiology and Cardiovascular Medicine, business
Abstract

Background Continuous-flow left ventricular assist devices (LVADs) improve the hemodynamics of patients with advanced heart failure. However, the longitudinal trajectories of hemodynamics in patients after LVAD implantation remain unknown. The aim of this study was to investigate the trends of hemodynamic parameters following LVAD implantation. Methods and Results We retrospectively reviewed patients who underwent LVAD implantation between April 2014 and August 2018. We collected hemodynamic parameters from right heart catheterizations. Of 199 consecutive patients, we enrolled 150 patients who had both pre- and postimplant right heart catheterizations. They had 3 (2, 4) postimplant right heart catheterizations during a follow-up of 2.3 (1.3, 3.1) years. The mean age was 57 ± 13 years, and 102 patients (68%) were male. Following LVAD implantation, pulmonary arterial pressure and pulmonary capillary wedge pressure decreased, and cardiac index increased significantly, then remained unchanged throughout follow-up. Right atrial pressure decreased initially and then gradually increased to preimplant values. The pulmonary artery pulsatility index decreased initially and returned to preimplant values, then progressively decreased over longer follow-up. Subgroup analysis showed significant differences in the trajectories of the pulmonary artery pulsatility index based on gender. Conclusions Despite improvement in left-side filling pressures and cardiac index following LVAD implantation, right atrial pressure increased and the pulmonary artery pulsatility index decreased over time, suggesting progressive right ventricular dysfunction.

Published
2019

35. Deployment of Polarbear-2A

Author

Chang Feng, Radek Stompor, Takayuki Tomaru, Rolando Dünner, Josquin Errard, D. Tanabe, Praween Siritanasak, N. Stebor, Julien Carron, D. Leon, Davide Poletti, K. Cheung, C. Tsai, S. Takakura, Grant Teply, Yuto Minami, Yuki Inoue, Stephen M. Feeney, Yuji Chinone, Frederick Matsuda, D. Beck, Akito Kusaka, Y. Akiba, A. Suzuki, Nicoletta Krachmalnicoff, Adrian T. Lee, M. Aguilar Faúndez, J. Peloton, Colin Ross, Osamu Tajima, D. Boettger, B. Westbrook, A. T. P. Pham, M. Navaroli, N. W. Halverson, Y. Zhou, Federico Bianchini, A. Cukierman, Aashrita Mangu, Nobuhiko Katayama, T. Hamada, Tucker Elleflot, Y. Segawa, Masaya Hasegawa, G. Hall, Julian Borrill, Peter A. R. Ade, Eric V. Linder, Giulio Fabbian, H. Nishino, G. Jaehnig, Giuseppe Puglisi, Charles A. Hill, Shunsuke Adachi, S. Takatori, L. Howe, A. J. Gilbert, H. El-Bouhargani, Christian L. Reichardt, Kam Arnold, John Groh, Masashi Hazumi, Neil Goeckner-Wald, Nicholas Galitzki, S. Beckman, Brian Keating, M. A. Dobbs, Carlo Baccigalupi, Clara Vergès, Theodore Kisner, Reijo Keskitalo, Daisuke Kaneko, T. Fujino, S. Kikuchi, Darcy Barron, L. N. Lowry, Scott Chapman, Maximiliano Silva-Feaver, Oliver Jeong, Kevin T. Crowley, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Kaneko, D, Adachi, S, Ade, P, Aguilar Faundez, M, Akiba, Y, Arnold, K, Baccigalupi, C, Barron, D, Beck, D, Beckman, S, Bianchini, F, Boettger, D, Borrill, J, Carron, J, Chapman, S, Cheung, K, Chinone, Y, Crowley, K, Cukierman, A, Dobbs, M, Dunner, R, El-Bouhargani, H, Elleflot, T, Errard, J, Fabbian, G, Feeney, S, Feng, C, Fujino, T, Galitzki, N, Gilbert, A, Goeckner-Wald, N, Groh, J, Hall, G, Halverson, N, Hamada, T, Hasegawa, M, Hazumi, M, Hill, C, Howe, L, Inoue, Y, Jaehnig, G, Jeong, O, Katayama, N, Keating, B, Keskitalo, R, Kikuchi, S, Kisner, T, Krachmalnicoff, N, Kusaka, A, Lee, A, Leon, D, Linder, E, Lowry, L, Mangu, A, Matsuda, F, Minami, Y, Navaroli, M, Nishino, H, Peloton, J, Pham, A, Poletti, D, Puglisi, G, Reichardt, C, Ross, C, Segawa, Y, Silva-Feaver, M, Siritanasak, P, Stebor, N, Stompor, R, Suzuki, A, Tajima, O, Takakura, S, Takatori, S, Tanabe, D, Teply, G, Tomaru, T, Tsai, C, Verges, C, Westbrook, B, Zhou, Y, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)

Subjects
[PHYS]Physics [physics], Settore FIS/05, Gravitational wave, Cosmic microwave background, Millimeter wave, First light, CMB, Condensed Matter Physics, 7. Clean energy, 01 natural sciences, Atomic and Molecular Physics, and Optics, 010305 fluids & plasmas, Microwave emission, Settore FIS/05 - Astronomia e Astrofisica, TES bolometer, Planet, Software deployment, 0103 physical sciences, Extremely high frequency, B-mode polarization, General Materials Science, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Remote sensing
Abstract

International audience; Polarbear-2A is the first of three receivers in the Simons array, a cosmic microwave background experiment located on the Atacama Plateau in Chile. Polarbear-2A was deployed and achieved the first light in January 2019 by mapping the microwave emission from planet observations. Commissioning work is underway to prepare the receiver for science observations.

Published
2019
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36. Deep Y-Descent in Right Atrial Waveforms Following Left Ventricular Assist Device Implantation

Author

D. Nitta, Luise Holzhauser, Takeyoshi Ota, Sara Kalantari, Tae Song, Nir Uriel, T. Fujino, Gabriel Sayer, Ann Nguyen, Valluvan Jeevanandam, Gene Kim, Teruhiko Imamura, Bryan Smith, Nikhil Narang, and Daniel Rodgers

Subjects
Male, Gastrointestinal bleeding, medicine.medical_specialty, medicine.medical_treatment, Ventricular Dysfunction, Right, Hemodynamics, 030204 cardiovascular system & hematology, Right atrial, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Adverse effect, Stroke, Retrospective Studies, Heart Failure, business.industry, Middle Aged, medicine.disease, equipment and supplies, Impaired right ventricular function, Echocardiography, Heart failure, Ventricular assist device, Cardiology, Ventricular Function, Right, Heart-Assist Devices, Cardiology and Cardiovascular Medicine, business
Abstract

Background Characterization of right heart catheterization (RHC) waveforms provides diagnostic and clinical information in heart failure patients. We aimed to investigate the implication of RHC waveforms, specifically the y-descent, in patients with left ventricular assist device (LVAD). Methods and Results Patients underwent RHC and waveforms were quantified prior to and 6 months after LVAD implantation. The impact of a deep y-descent (>3 mmHg) on echocardiographic measures of right heart function and 1-year hemocompatibility-related adverse event rates were investigated. Eighty-nine patients (median 59 years old, 65 male) underwent RHC. RHC waveform showed unique changes following LVAD implantation, particularly an increase in the steepness of the y-descent. A post-LVAD deep y-descent was associated with reduced right ventricular function and enlarged right heart. Patients with post-LVAD deep y-descent had higher rates of gastrointestinal bleeding (0.866 vs 0.191 events/year) and stroke (0.199 vs 0 events/year) compared with those without (P Conclusion RHC waveforms characterized by deep y-descent on RHC waveform during LVAD support was associated with impaired right ventricular function and worse clinical outcomes.

Published
2019

37. HeartWare Ventricular Assist Device Cannula Position and Hemocompatibility-Related Adverse Events

Author

Takeyoshi Ota, Nir Uriel, D. Nitta, Jayant Raikhelkar, Ben Chung, Gene Kim, Ann Nguyen, Gabriel Sayer, Valluvan Jeevanandam, Nikhil Narang, Luise Holzhauser, Colleen Juricek, Teruhiko Imamura, Sara Kalantari, Tae Song, T. Fujino, Bryan Smith, and Daniel Rodgers

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Cardiac Catheterization, medicine.medical_treatment, Hemodynamics, Intracardiac pressure, 030204 cardiovascular system & hematology, Ventricular Function, Left, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine.artery, medicine, Cannula, Humans, Prospective cohort study, Aged, Retrospective Studies, Heart Failure, business.industry, Middle Aged, medicine.disease, 030228 respiratory system, Echocardiography, Ventricular assist device, Heart failure, Coronal plane, Pulmonary artery, Cardiology, Surgery, Female, Heart-Assist Devices, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract

BACKGROUND. HeartWare ventricular assist device (HVAD) cannula position is associated with hemodynamics and heart failure readmissions. However, its impact on hemocompatibility-related adverse events (HRAEs) remains uncertain. METHODS. HVAD patients were followed for 1 year after index hospitalization, when cannula coronal angle was quantified from chest x-ray film. Invasive right heart catheterization and transthoracic echocardiography were performed. One-year occurrences of each HRAE were compared between those with and without a cannula coronal angle of greater than 65 degrees. RESULTS. Among 63 HVAD patients (median age 60 years, 63% male), 10 (16%) had a cannula coronal angle greater than 65 degrees. The wide-angle group had elevated intracardiac pressures and lower pulmonary artery pulsatility index (P < .05). They also had reduced right ventricular function by echocardiography. Freedom from HRAEs tended to be lower in the wide-angle group (24% vs 62%; P = .11). The rate of gastrointestinal bleeding was significantly higher in the greater than 65 degrees group (0.90 events/year vs 0.40 events/year; P = .013). The rates of stroke and pump thrombosis were statistically comparable irrespective of cannula angle (P > .05). CONCLUSIONS. HVAD cannula coronal angle was associated with reduced right ventricular function and HRAEs. Prospective studies evaluating surgical techniques to ensure optimal device positioning and its effects on HRAEs are warranted.

Published
2019

38. Effect of Concomitant Tricuspid Valve Surgery With Left Ventricular Assist Device Implantation

Author

Ben Chung, Colleen Juricek, Nikhil Narang, D. Nitta, Bryan Smith, T. Fujino, Ann Nguyen, Daniel Rodgers, Gabriel Sayer, Sara Kalantari, Teruhiko Imamura, Tae Song, Daniel Burkhoff, Takeyoshi Ota, Nir Uriel, Gene Kim, Valluvan Jeevanandam, and Luise Holzhauser

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Regurgitation (circulation), 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, In patient, TRICUSPID VALVE REPAIR, Aged, Retrospective Studies, Heart Failure, Heart Valve Prosthesis Implantation, Tricuspid valve, business.industry, Retrospective cohort study, Middle Aged, medicine.disease, equipment and supplies, Tricuspid Valve Insufficiency, Surgery, medicine.anatomical_structure, Treatment Outcome, 030228 respiratory system, Echocardiography, Concomitant, Ventricular assist device, Heart failure, Female, Heart-Assist Devices, Tricuspid Valve, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract

BACKGROUND: Tricuspid regurgitation (TR) is common in advanced heart failure (HF) patients. However, the effect of concomitant tricuspid valve repair or replacement (tricuspid valve intervention, TVI) with left ventricular assist device (LVAD) implantation is controversial. The aim of this study was to investigate the longitudinal trend of TR following LVAD implantation, and the effect of TVI on the TR trend and clinical outcomes. METHODS: We retrospectively reviewed patients at our institution who underwent LVAD implantation between April 2014 and August 2018. We evaluated the grade of TR by echocardiography prior to and following LVAD implantation. Moderate or greater TR was defined as significant. RESULTS: Among 199 consecutive patients, 194 patients had at least 2 echocardiographic TR assessments prior to and following LVAD implantation. Of these, 108 patients were included in the TVI+ group and 86 in the TVI− group. In the TVI+ group, the prevalence of significant TR decreased from 52% to about 20% in the first 6 months following implantation (P

Published
2019

39. LiteBIRD: A Satellite for the Studies of B-Mode Polarization and Inflation from Cosmic Background Radiation Detection

Author

Josquin Errard, Kent D. Irwin, Ingunn Kathrine Wehus, Kazunori Kohri, Kam Arnold, Atsushi Okamoto, Osamu Tajima, T. Tomida, Hirokazu Ishino, L. Montier, T. Kawasaki, M. Willer, Ryo Yamamoto, Nobuhiko Katayama, B. Thorne, Eiichiro Komatsu, Takayuki Tomaru, Benjamin Westbrook, Toshiaki Iida, Tadayasu Dotani, Yuki Inoue, T. Funaki, Chiko Otani, Bruno Maffei, L. Hayes, Charles A. Hill, F. Vansyngel, T. Nagasaki, L. Duband, Tucker Elleflot, H. Imada, Johannes Hubmayr, A. Cukierman, M. Nakajima, T. Hasebe, Paul Turin, A. Dominjon, Eric V. Linder, S. Takatori, Toshifumi Shimizu, Yuto Minami, Shin Utsunomiya, Y. Sato, Yoshinori Uzawa, D. Tanabe, J. M. Duval, F. Boulanger, Takahiro Okamura, Jo Dunkley, Hiroyuki Sugita, Masato Naruse, Julian Borrill, Makoto Hattori, Theodore Kisner, Yuji Chinone, Tom Nitta, Dale Li, Mathieu Remazeilles, K. Ganga, Hideo Ogawa, Reijo Keskitalo, Masashi Hazumi, Giampaolo Pisano, E. Taylor, S. Takakura, H. Kanai, Jun-ichi Suzuki, N. Sato, Masahiro Tsujimoto, Yutaro Sekimoto, Shin-ichiro Sakai, Kimihiro Kimura, M. Nagai, N. W. Halverson, Anna Mangilli, Seongjae Cho, M. Tristram, S. A. Kernasovskiy, Jonathan Aumont, Blake D. Sherwin, Carole Tucker, Tomotake Matsumura, Kiyotomo Ichiki, Satoru Mima, T. de Haan, T. Hamada, N. Tomita, G. Patanchon, K. Komatsu, Shuji Matsuura, J. Grain, Paul L. Richards, Norio Okada, N. Hidehira, Kazuhisa Mitsuda, Soumen Basak, Yasuhiro Yamada, Aritoki Suzuki, H. K. Eriksen, Hajime Sugai, Shogo Nakamura, Peter A. R. Ade, Alex Lazarian, T. Fujino, Y. Akiba, Gabriel M. Rebeiz, H. Nishino, Nathan Whitehorn, Martin Bucher, R. Stompor, Shingo Kashima, A. Kibayashi, Y. Kida, Noah Kurinsky, D. W. Curtis, M. Inoue, Masaya Hasegawa, Adrian T. Lee, Shugo Oguri, Y. Segawa, David Alonso, A. Ducout, Carlo Baccigalupi, U. Fuskeland, S. Beckman, Uroš Seljak, R. Nagata, J. Fischer, Mitsuhiro Yoshida, K. L. Thompson, Darcy Barron, Gene C. Hilton, Noriko Y. Yamasaki, Erminia Calabrese, Neil Goeckner-Wald, R. Takaku, Suguru Takada, M. A. Dobbs, Oliver Jeong, Toshiya Namikawa, Yuki Sakurai, Chao-Lin Kuo, Kaori Hattori, Keisuke Shinozaki, D. Meilhan, M. Maki, Makoto Sawada, D. Kaneko, T. Yamashita, S. Uozumi, Takashi Noguchi, Akito Kusaka, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Service des Basses Températures (SBT ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire des Cryoréfrigérateurs et Cryogénie Spatiale (LCCS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
detector: cryogenics, Cosmic microwave background, Cosmic background radiation, cosmic background radiation: polarization, Lagrangian point, B-mode polarization, Cosmic inflation, Primordial gravitational wave, Quantum gravity, Satellite, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, 01 natural sciences, 010305 fluids & plasmas, law.invention, Telescope, Settore FIS/05 - Astronomia e Astrofisica, bolometer, law, 0103 physical sciences, General Materials Science, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], detector: optical, 010306 general physics, Physics, Bolometer, gravitational radiation: primordial, Astrophysics::Instrumentation and Methods for Astrophysics, Condensed Matter Physics, Polarization (waves), inflation: model, Atomic and Molecular Physics, and Optics, detector: sensitivity, modulation, Cardinal point, B-mode, angular resolution, moment: multipole, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Multipole expansion
Abstract

著者人数: 152名(所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 羽澄, 昌史; 堂谷, 忠靖; 長谷部, 孝; 今田, 大皓; 満田, 和久; 坂井, 真一郎; 関本, 裕太郎; Tomida, T.; 辻本, 匡弘; Yamamoto, R.; 山崎, 典子), Accepted: 2019-01-18, 資料番号: SA1180402000

Published
2019
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40. Copper contaminated water mediated biochemical changes on charophyte species Chara braunii

Author

A Herbst, T Fujino, and V P Ranawakage

Subjects
chemistry.chemical_classification, Reactive oxygen species, Antioxidant, biology, medicine.medical_treatment, General Medicine, General Chemistry, biology.organism_classification, Pigment, chemistry.chemical_compound, chemistry, Catalase, Chara braunii, visual_art, medicine, biology.protein, visual_art.visual_art_medium, Food science, Hydrogen peroxide, Carotenoid, Peroxidase
Abstract

Over the past few decades water bodies have been heavily contaminated by the heavy metals thus charophytes communities tended to disappear from their own habitat niches. In this experiment we hypothesized that elevating Cu concentrations and increasing exposure time deviates the biochemical responses ofChara braunii. For evaluating this hypothesis we considered changes in plant reactive oxygen species (ROS) mainly as hydrogen peroxide. Thereafter, scavenging antioxidant activities were measured (POD, CAT) while pigment content assessed means of Chla, Chlband Carotenoids. Each treatment contains 3 replicates and subjected to four levels of Cu concentrations (0ppm, 1ppm, 5ppm, and 10ppm) for over four days respectively. Compared to the control, all dosages of Cu concentrations and exposure times were caused to trigger H2O2generation. Observed results revealed that dramatic increases of H2O2level on the 1stday of copper contamination by the 10ppm concentration. Conversely, after 1stday H2O2content continuously tended to decreases and in 4thday it shown the lowest value. Moreover,C. brauniiexhibited significant increase in the catalase activity and peroxidase activity for detoxifying Cu toxicity for short duration whereas inhibited antioxidant activity on prolonged exposure. Consequently, chlorophyll pigments content impaired significantly and deteriorated plant color suggests subjected plant were under extreme stress. This study results indicated that exposure to Cu contaminated water is lethal for charophyte growth and the physiological process by enhancing oxidative damages to the cells.

Published
2021
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41. Radiation Tolerance of Aluminum Microwave Kinetic Inductance Detector

Author

Shibo Shu, T. Yamashita, Masato Naruse, Takashi Noguchi, Shigeyuki Sekiguchi, Masashi Hazumi, Masakazu Sekine, Agnes Dominjon, Kenichi Karatsu, N. Oka, Tomotake Matsumura, Tom Nitta, Yasuhiro Yamada, Yutaro Sekimoto, K. Mizukami, T. Funaki, T. Fujino, Hirokazu Ishino, F. Irie, and Y. Kida

Subjects
Physics, Proton, Physics::Instrumentation and Detectors, business.industry, Microwave kinetic inductance detectors, Astrophysics::Instrumentation and Methods for Astrophysics, LiteBIRD, Substrate (electronics), Condensed Matter Physics, 01 natural sciences, Atomic and Molecular Physics, and Optics, Radiation tolerance, Resonator, Responsivity, Optics, Absorbed dose, 0103 physical sciences, General Materials Science, Irradiation, Satellite mission, 010306 general physics, business, 010303 astronomy & astrophysics, Microwave, Beam (structure)
Abstract

著者人数: 20名, Accepted: 2016-01-21, 資料番号: SA1160044000

Published
2016
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42. Absence of Aortic Valve Opening after Hemodynamic Ramp Optimization Study Does Not Impact LVAD Morbidity of Mortality

Author

Sara Kalantari, Tae Song, Anh Nguyen, Gabriel Sayer, Natasha Mehta, Nir Uriel, Daniel Rodgers, M. Dela Cruz, Bow Chung, Jonathan Grinstein, Bryan Smith, T. Fujino, Gene Kim, Takeyoshi Ota, Nitasha Sarswat, Luise Holzhauser, Jayant Raikhelkar, and Valluvan Jeevanandam

Subjects
Pulmonary and Respiratory Medicine, Aortic valve, Transplantation, medicine.medical_specialty, business.industry, Hemodynamics, equipment and supplies, Right atrial, medicine.anatomical_structure, Native valve, Internal medicine, cardiovascular system, Cardiology, medicine, Overall survival, Surgery, In patient, Single institution, Cardiology and Cardiovascular Medicine, business
Abstract

Purpose Aortic valve opening in patients supported by left ventricular assist devices (LVAD) preserves native valve geometry and structure and reduces rates of aortic insufficiency and need for aortic valve interventions. With LVAD speed optimization studies (Ramp studies) hemodynamic optimization can sometimes come at the expense of aortic valve opening. Here we explore the impact of aortic valve opening after optimization on morbidity and mortality. Methods LVAD Patients from a single institution underwent simultaneous echocardiographic (TTE) and hemodynamic LVAD ramp study. Patients were deemed optimized when their hemodynamic profile reached a target right atrial (RA) pressure 2.2L/min/m2. The impact of presence or absence of aortic valve opening on readmission-free survival, hemocompatibility related adverse events (HRAE)-free survival and overall survival at 3 years was determined. Results 113 LVAD patients were included in the analysis (62=HMII, 34=HVAD, 17 =HM3). Mean CI was 2.73L/min/m2, RAP 9.4mmHg and PCWP 13.7mmHg after optimization. 52 patients had absence of aortic valve opening at their set speed. There was no difference in overall survival (p = 0.89), HF admissions (p = 0.81) and HRAE (p = 0.85) at 3 years in those with and without aortic valve opening (Figure A-C). Conclusion Absence of aortic valve opening after LVAD speed optimization did not demonstrate more adverse events or LVAD-related morbidity and mortality compared to those who had aortic valve opening. Speed optimization should focus on hemodynamic optimization with less emphasis on aortic valve opening.

Published
2020
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43. Prognostication of Residual Mitral Regurgitation or Aortic Insufficiency after Invasive Hemodynamic Ramp Optimization

Author

Sara Kalantari, Tae Song, Bryan Smith, Daniel Rodgers, Jayant Raikhelkar, Nehal N. Mehta, Dongbo Yu, Valluvan Jeevanandam, Nir Uriel, T. Fujino, Anh Nguyen, Gene Kim, Luise Holzhauser, M. DelaCruz, Bow Chung, Mark N. Belkin, Takeyoshi Ota, Nitasha Sarswat, Gabriel Sayer, and Jonathan Grinstein

Subjects
Pulmonary and Respiratory Medicine, Transplantation, medicine.medical_specialty, Mitral regurgitation, business.industry, Hemodynamics, Residual, medicine.disease, Heart failure, Internal medicine, Cohort, Cardiology, Overall survival, Medicine, Surgery, Cardiology and Cardiovascular Medicine, business, Adverse effect
Abstract

Purpose LVAD speed optimization via invasive ramp studies have been shown to reduce LVAD related morbidity. Many LVAD implanting centers use non-invasive echocardiographic (TTE) ramp studies for optimization and use mitral (MR) and aortic insufficiency (AI) severity as surrogates for unloading and optimization. We examined the prognostic value of residual MR and AI after invasive hemodynamic optimization. Methods Patients underwent simultaneous TTE and hemodynamic LVAD ramp study with hemodynamic and TTE measurements at each incremental speed increase. The device was set at a speed that demonstrated an optimized hemodynamic profile with target CVP 2.2L/min/m2. MR and AR severity at the optimized speed was quantified by TTE and the impact of residual regurgitant lesions on heart failure (HF) readmission-free survival and hemocompatibility related adverse events (HRAE) free survival and overall survival at 3 years was determined. Results After hemodynamic optmization, mean PCWP was 13.7mmHg, CI was 2.73L/min/m2 and RAP was 9.4mmHg for the entire cohort. 24 patients had residual mild/moderate or greater AI and 27 patients had mild or greater MR after optimization. Freedom from HRAE was higher in those without residual AI (45% vs 24%, p =0.05) at 3 years with no difference in overall survival or HF admission (Figure Top). Patients without residual MR had higher 3 year survival compared to those with residual MR (75% vs 51%, p =0.03). There was a trend toward higher HRAE and HF readmission rates in those with residual MR (Figure Bottom). Conclusion Residual AI and MR after LVAD hemodynamic speed optimization has negative consequences with regard to HRAE and HF readmission-free survival and overall mortality at 3 years. Additional speed optimization may be needed in this cohort to mitigate morbidity and mortality.

Published
2020
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44. Donor-Derived Cell-Free DNA Does Not Correlate with Levels of Inflammation or Angiogenesis in a Stable Post Transplant Population

Author

Luise Holzhauser, T. Fujino, Gabriel Sayer, Jayant Raikhelkar, Gene Kim, Nir Uriel, Anh Nguyen, and Francis J. Alenghat

Subjects
Pulmonary and Respiratory Medicine, Transplantation, education.field_of_study, TGF alpha, medicine.diagnostic_test, business.industry, Angiogenesis, Population, Inflammation, Vascular endothelial growth factor, chemistry.chemical_compound, chemistry, Cell-free fetal DNA, Immunoassay, Immunology, medicine, Surgery, Tumor necrosis factor alpha, medicine.symptom, Cardiology and Cardiovascular Medicine, education, business
Abstract

Purpose Donor-derived cell-free DNA (dd-cfDNA) has recently been introduced as a novel marker of acute cellular and antibody mediated rejection. We hypothesized that levels of dd-cfDNA would correlate with markers of chronic inflammation and angiogenesis in a stable post-transplant population. Methods 65 heart transplant recipients who were 8.5±5.4 years post transplant were enrolled at routine clinic visits. Exclusion criteria for the study were episodes of rejection within 6 months or recent infection. Peripheral blood protein expression of interluekin-6 (IL-6), interluekin-18 (IL-18), tumor necrosis factor-alpha (TNF-α), soluble Fas-ligand (sFASL), angiopoetin-2, vascular endothelial growth factor (VEGF) A, C and D and transforming growth factor alpha (TGF-α) was assessed using a multiplex immunoassay system (Bioplex®). Dd-cfDNA was measured using a targeted amplification, next generation-sequencing assay (AlloSure®; CareDx, Inc.). Results Patients were stratified for levels of dd-cfDNA % as low and high defined as above (≥0.14%) or below the mean ( Conclusion Inflammatory and angiogenesis cytokines are not associated with levels of dd-cfDNA in a stable post transplant population. Further studies of should investigate if temporal changes can predict adverse outcomes.

Published
2020
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45. Donor-Derived Cell-Free DNA is Associated with Cardiac Allograft Vasculopathy

Author

Jayant Raikhelkar, Gabriel Sayer, T. Fujino, Luise Holzhauser, Gene Kim, Francis J. Alenghat, and Nir Uriel

Subjects
Pulmonary and Respiratory Medicine, Transplantation, medicine.medical_specialty, medicine.diagnostic_test, biology, business.industry, Disease, Cardiac allograft vasculopathy, Post transplant, Cell-free fetal DNA, Internal medicine, Cohort, Intravascular ultrasound, cardiovascular system, Cardiology, biology.protein, Medicine, Surgery, Donor derived, Antibody, Cardiology and Cardiovascular Medicine, business
Abstract

Purpose There is mounting evidence on the use of donor-derived cell-free DNA (dd-cfDNA) as a non-invasive tool to detect acute antibody and cellular mediated rejection. However the role of dd-cfDNA in detecting and monitoring cardiac allograft vasculopathy (CAV) in the absence of acute rejection remains unknown. We hypothesized that dd-cfDNA levels would correlate with the presence of CAV. Methods 65 clinically stable heart transplant recipients ≥ 2 years post-transplant, with no rejection episodes in the preceding 6 months were enrolled. CAV was assessed by routine coronary angiogram and intravascular ultrasound. Patients were stratified by time since transplant (2-5, 5-10 and ≥ 10 years post transplant) and high versus low levels of dd-cfDNA defined as above and below the median. Significant CAV was defined as Stanford III-IV or angiographic disease. A targeted amplification, next generation-sequencing assay (AlloSure®; CareDx, Inc.) was used to detect dd-cfDNA. Results Of 58 patients with known CAV status, 30 had high levels of ddcf-DNA (≥0.14%) and 28 had low levels ( Conclusion dd-cfDNA levels were associated with CAV in a cohort of stable transplant recipients >2 years post HT and thus might help to identify those in need for invasive assessment. Further studies should investigate if there is an association between dd-cfDNA levels and CAV severity and whether dd-cfDNA levels can predict CAV progression.

Published
2020
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46. Hypogammaglobulinemia Following Heart Transplantation - Prevalence and Clinical Importance

Author

Daniel Rodgers, T. Fujino, Yuto Kumai, Nir Uriel, Laura Lourenco, Bow Chung, Gene Kim, Anh Nguyen, D. Nitta, Gabriel Sayer, and Jayant Raikhelkar

Subjects
Pulmonary and Respiratory Medicine, Heart transplantation, Transplantation, medicine.medical_specialty, business.industry, medicine.medical_treatment, Immunosuppression, Mean age, medicine.disease, Hypogammaglobulinemia, Internal medicine, Overall survival, Medicine, Surgery, In patient, Clinical significance, Cardiology and Cardiovascular Medicine, business
Abstract

Purpose Hypogammaglobulinemia (HGG) can be identified in patients following solid organ transplantation and is thought to be predominantly due to immunosuppression. There is limited data describing the extent, degree and clinical outcomes associated with HGG following heart transplantation. The aim of this study is to investigate the prevalence and clinical significance of HGG in heart transplant recipients. Methods We retrospectively reviewed data of patients who had underwent heart transplantation at our institution between 4/2014 and 12/2018. We excluded patients with multi-organ transplantation. We defined serum IgG Results We enrolled 132 patients who had at least one serum IgG value following heart transplantation during the study period. Mean age was 53±14 years old and 94 (71%) patients were male. During 761 (463, 1266) days of follow-up, patients had a median of 4 (3, 6) IgG measurements. Prevalence of severe HGG was highest (27%) 3-6 months post-heart transplant and then decreased to 5% at 1-2 years (Figure A). Survival freedom of infection was 51%, 35% and 17% at 2 years in the normal, mild HGG and severe HGG groups, respectively (P=0.03, Figure B). Overall survival and rejection-free survival were comparable between the groups. Conclusion There is a high prevalence of HGG in the early post-heart transplant period that decreases over time. HGG is significantly associated with infectious complications. Further studies are needed to investigate the prophylactic treatment of HGG with IVIG in heart transplant recipients.

Published
2020
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48. Study of multi-neutron systems with SAMURAI spectrometer

Author

K. Yoneda, Z. Elekes, Masaki Sasano, Heiko Scheit, Atsumi Saito, N. Inabe, I. Stefan, J. Tscheuschner, Mohsen Harakeh, Julien Gibelin, M. A. Knösel, K. Boretzky, Z. Ge, Takashi Nakamura, D. Kim, H. Sato, J. Kahlbow, Igor Gašparić, Y. Yasuda, Susumu Shimoura, T. Isobe, Juzo Zenihiro, M. Caamaño, Yosuke Kondo, S. Masuoka, H. Suzuki, A. Hirayama, S. W. Huang, C. A. Douma, B. M. Godoy, Z. Halász, H. Yamada, C. Lehr, M. Böhmer, Nobuyuki Chiga, A. Revel, N. L. Achouri, P. Koseoglou, Kathrin Wimmer, V. Wagner, N. A. Orr, M. Potlog, M. Miwa, B. Yang, A. Obertelli, T. Harada, H. T. Törnqvsit, S. Reichert, H. Miki, D. S. Ahn, T. Tomai, István Kuti, J. Mayer, J. Tanaka, S. Park, Yasuhiro Togano, M. Parlog, Naoki Fukuda, Yu-xin Liu, S. Chen, V. Panin, L. Zanetti, F. Schindler, S. Storck, T. Shimada, Tomohiro Uesaka, J. Feng, M. Matsumoto, Zaihong Yang, U. Forsberg, Roman Gernhäuser, I. Murray, F. Dufter, D. Symochko, L. Stuhl, J. M. Gheller, Hideaki Otsu, D. Beaumel, T. Kobayashi, H. Takeda, A. Gillibert, D. Cortina, P. Doornenbal, L. Yang, Nasser Kalantar-Nayestanaki, Satoshi Takeuchi, Thomas Aumann, Stefanos Paschalis, T. Fujino, D. M. Rossi, H. Baba, Yohei Shimizu, M. L. Cortés, F. M. Marqués, B. Fernández-Domínguez, Yuya Kubota, Yukie Maeda, S. K. Kim, P. J. Li, Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
Physics, Firm conclusion, Spectrometer, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, 010305 fluids & plasmas, Nuclear physics, 0103 physical sciences, Tetraneutron, Neutron, Nuclear Experiment (nucl-ex), 010306 general physics, Nuclear Experiment
Abstract

The tetraneutron has been drawing the attention of the nuclear physics community for decades, but a firm conclusion on its existence and properties is still far from being reached despite many experimental and theoretical efforts. New measurements have recently been performed at RIBF with the SAMURAI spectrometer by applying complementary reaction probes, which will help to pin down the properties of this four-neutron system., Comment: 5 pages, 2 figures, conference proceedings of XXII International Conference on Few-Body Problems in Physics (FB22), Caen, France, July 2018

Published
2018
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49. The LiteBIRD Satellite Mission: Sub-Kelvin Instrument

Author

A. Suzuki, P. A. R. Ade, Y. Akiba, D. Alonso, K. Arnold, J. Aumont, C. Baccigalupi, D. Barron, S. Basak, S. Beckman, J. Borrill, F. Boulanger, M. Bucher, E. Calabrese, Y. Chinone, S. Cho, B. Crill, A. Cukierman, D. W. Curtis, T. de Haan, M. Dobbs, A. Dominjon, T. Dotani, L. Duband, A. Ducout, J. Dunkley, J. M. Duval, T. Elleflot, H. K. Eriksen, J. Errard, J. Fischer, T. Fujino, T. Funaki, U. Fuskeland, K. Ganga, N. Goeckner-Wald, J. Grain, N. W. Halverson, T. Hamada, T. Hasebe, M. Hasegawa, K. Hattori, M. Hattori, L. Hayes, M. Hazumi, N. Hidehira, C. A. Hill, G. Hilton, J. Hubmayr, K. Ichiki, T. Iida, H. Imada, M. Inoue, Y. Inoue, K. D. Irwin, H. Ishino, O. Jeong, H. Kanai, D. Kaneko, S. Kashima, N. Katayama, T. Kawasaki, S. A. Kernasovskiy, R. Keskitalo, A. Kibayashi, Y. Kida, K. Kimura, T. Kisner, K. Kohri, E. Komatsu, K. Komatsu, C. L. Kuo, N. A. Kurinsky, A. Kusaka, A. Lazarian, A. T. Lee, D. Li, E. Linder, B. Maffei, A. Mangilli, M. Maki, T. Matsumura, S. Matsuura, D. Meilhan, S. Mima, Y. Minami, K. Mitsuda, L. Montier, M. Nagai, T. Nagasaki, R. Nagata, M. Nakajima, S. Nakamura, T. Namikawa, M. Naruse, H. Nishino, T. Nitta, T. Noguchi, H. Ogawa, S. Oguri, N. Okada, A. Okamoto, T. Okamura, C. Otani, G. Patanchon, G. Pisano, G. Rebeiz, M. Remazeilles, P. L. Richards, S. Sakai, Y. Sakurai, Y. Sato, N. Sato, M. Sawada, Y. Segawa, Y. Sekimoto, U. Seljak, B. D. Sherwin, T. Shimizu, K. Shinozaki, R. Stompor, H. Sugai, H. Sugita, J. Suzuki, O. Tajima, S. Takada, R. Takaku, S. Takakura, S. Takatori, D. Tanabe, E. Taylor, K. L. Thompson, B. Thorne, T. Tomaru, T. Tomida, N. Tomita, M. Tristram, C. Tucker, P. Turin, M. Tsujimoto, S. Uozumi, S. Utsunomiya, Y. Uzawa, F. Vansyngel, I. K. Wehus, B. Westbrook, M. Willer, N. Whitehorn, Y. Yamada, R. Yamamoto, N. Yamasaki, T. Yamashita, M. Yoshida, Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA (UMR_8112)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Service des Basses Températures (SBT ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire des Cryoréfrigérateurs et Cryogénie Spatiale (LCCS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
Cosmic microwave background, FOS: Physical sciences, cosmic background radiation: polarization, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Radio spectrum, law.invention, Antenna array, Telescope, Optics, bolometer, Settore FIS/05 - Astronomia e Astrofisica, law, Polarization, 0103 physical sciences, B-mode, Inflation, Satellite, General Materials Science, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, activity report, detector: design, Physics, 010308 nuclear & particles physics, business.industry, Gravitational wave, Detector, Bolometer, Astrophysics::Instrumentation and Methods for Astrophysics, Condensed Matter Physics, Astrophysics - Astrophysics of Galaxies, Atomic and Molecular Physics, and Optics, cryogenics, Astrophysics of Galaxies (astro-ph.GA), electronics: readout, interference: quantum, Transition edge sensor, Astrophysics - Instrumentation and Methods for Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], business, cosmic background radiation: anisotropy
Abstract

著者人数: 153名（所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 堂谷, 忠靖; 羽澄, 昌史; 今田, 大皓; 満田, 和久; 坂井, 真一郎; Tomida, T.; 辻本, 匡弘; Yamamoto, R.; 山崎, 典子）, Accepted: 2018-04-30, 資料番号: SA1180210000

Published
2018
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50. Decoupling between Pulmonary Artery and Wedge Pressure is Associated with Hemocompatibility-Related Adverse Events Following LVAD Implantation

Author

Sara Kalantari, Tae Song, Anh Nguyen, Pamela Combs, Teruhiko Imamura, V. Jeevanandam, David Onsager, D. Nitta, Nir Uriel, Gabriel Sayer, Nikhil Narang, Colleen Juricek, Bow Chung, Luise Holzhauser, Daniel Rodgers, Jayant Raikhelkar, Takeyoshi Ota, Imo A. Ebong, Bryan Smith, Gene Kim, and T. Fujino

Subjects
Pulmonary and Respiratory Medicine, Transplantation, medicine.medical_specialty, business.industry, Diastole, Hemodynamics, medicine.artery, Internal medicine, Pulmonary artery, medicine, Cardiology, Surgery, Cardiology and Cardiovascular Medicine, Adverse effect, Pump thrombosis, Prospective cohort study, business, Pulmonary wedge pressure, Decoupling (electronics)
Abstract

Purpose Hemocompatibility-related adverse events (HRAEs) are major causes of readmission in LVAD patients. Decoupling between diastolic pulmonary artery pressure (dPAP) and pulmonary capillary wedge pressure (PCWP) is an index of pulmonary vascular damage. This study assessed the implication of decoupling on HRAEs in LVAD patients. Methods In this prospective study LVAD patients underwent invasive hemodynamic tests and were followed for 1 year. Decoupling was defined as a difference >5 mmHg between dPAP and PCWP. One-year freedom from any HRAEs and the net burden of HRAEs, which was calculated by using a hemocompatibility score (using 4 escalating tiers of hierarchal severity to derive a total score for events), were compared between those with and without decoupling. Results Among 92 LVAD patients (median age 61 years, 57% male), 44 patients (48%) had decoupling. One-year freedom from any HRAEs was 49% in the decoupling group compared with 79% in the decoupling-free group (p = 0.005; Figure 1A). The average hemocompatibility score in the decoupling group was significantly higher compared with the control group (2.14 vs. 0.67; p = 0.004; Figure 1B), due to reduced Tier I (1-2 gastrointestinal bleedings or medically managed pump thrombosis; p = 0.027) and Tier IIIB scores (HRAEs-related death; p = 0.041). Conclusion The presence of decoupling between dPAP and PCWP was associated with HRAEs in LVAD patients. Studies evaluating if a reduction in decoupling will also reduce HRAE's is warranted.

Published
2019
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