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Your search keyword '"Szylberg, Tadeusz"' showing total 18 results
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18 results on '"Szylberg, Tadeusz"'

5. MGMT Promoter Methylation as a Prognostic Factor in Primary Glioblastoma: A Single-Institution Observational Study

Author

Szylberg, Mateusz, primary, Sokal, Paweł, additional, Śledzińska, Paulina, additional, Bebyn, Marek, additional, Krajewski, Stanisław, additional, Szylberg, Łukasz, additional, Szylberg, Aneta, additional, Szylberg, Tadeusz, additional, Krystkiewicz, Kamil, additional, Birski, Marcin, additional, Harat, Marek, additional, Włodarski, Robert, additional, and Furtak, Jacek, additional

Published
2022
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8. Mutations in the von Hippel-Lindau Tumour Suppressor Gene in Central Nervous System Hemangioblastomas

Author

Cybulski Cezary, Matyjasik Joanna, Soroka Marianna, Szymaś Janusz, Górski Bohdan, Dębniak Tadeusz, Jakubowska Anna, Bernaczyk Andrzej, Zimnoch Lech, Bierzyńska-Macyszyn Grażyna, Trojanowski Tomasz, Wierzba-Bobrowicz Teresa, Prudlak Edmund, Markowska-Wojciechowska Alicja, Nowacki Przemysław, Roszkiewicz Andrzej, Kordek Radzisław, Szylberg Tadeusz, Matyja Ewa, Zieliński Krzysztof, Woźniewicz Bogdan, Taraszewska Anna, Kozłowski Wojciech, and Lubiński Jan

Subjects
VHL disease, hemangioblastoma, germline mutations, VHL gene, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Genetics, QH426-470
Abstract

Abstract Central nervous system hemangioblastomas (cHAB) are rare tumours which most commonly arise in the cerebellum. Most tumours are sporadic, but as many as one third of cHABs occur in the course of the hereditary disorder - von Hippel-Lindau disease (VHL). In order to diagnose new VHL families in Poland we performed sequencing of the entire VHL gene in archival material (paraffin embedded hemangioblastoma tissues) in a large series of 203 unselected patients with cHAB. VHL gene mutations were detected in 70 (41%) of 171 tumour samples from which DNA of relatively good quality was isolated. We were able to obtain blood samples from 19 of mutation positive cases. Eight (42%) of these harboured germline mutations in persons from distinct undiagnosed VHL families.

Published
2004
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17. Duodenal bulb tumour of unknown origin.

Author

Hankiewicz-Ziołkowska K, Soboń M, Szylberg T, and Rudziński J

Abstract

Gastrointestinal stromal tumours (GIST) are rare mesenchymal neoplasms of the gastrointestinal tract. Their development typically depends on mutations in the Kit or PDGFRA gene. We have diagnosed and treated a duodenal bulb GIST in a 63-year-old woman. The confirmation of the diagnosis was made on the basis of a histological test after radical resection of the tumour. Making the right diagnosis is crucial for patients, since complex surgical and pharmacological approaches are effective even in the advanced stages of the disease. Nevertheless, radical surgical treatment is still the primary choice for patients with GIST.

Published
2014
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18. [Primary central nervous system vasculitis imitating a brain tumour--a case report].

Author

Wiszniewska M, Szylberg T, and Harat M

Subjects
Biopsy, Needle methods, Brain Neoplasms diagnosis, Cerebral Angiography methods, Cyclophosphamide therapeutic use, Diagnosis, Differential, Disease Progression, Glucocorticoids therapeutic use, Humans, Male, Middle Aged, Vasculitis, Central Nervous System diagnostic imaging, Vasculitis, Central Nervous System pathology, Brain diagnostic imaging, Brain pathology, Vasculitis, Central Nervous System diagnosis, Vasculitis, Central Nervous System drug therapy
Abstract

Primary central nervous system vasculitis (PCNSV) is a rare disease with an annual incidence rate of 2.4 cases per 1,000,000 person-years. PCNSV causes various neurological symptoms dominated by headache as well as consciousness and mental disturbances. The disease sometimes imitates a brain tumour on CT and rarely presents as stroke. The diagnosis of PCNSV is difficult and frequently requires a brain biopsy in which transmural vascular inflammation involving leptomeningeal or parenchymal vessels is typically found. Angiographic changes indicating an irregular course of vessels with characteristic segmental narrowing can be observed but sometimes the angiogram is normal. The authors present a 57-year-old man in whom PCNSV was diagnosed in brain biopsy. The patient was treated with corticosteroid pulses for 18 months with good effect lasting for 2.5 years. After one year of ending glucocorticoid therapy the symptoms had occurred again and in spite of combined therapy of glucocorticoids with cyclophosphamide the patient died.

Published
2008

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