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1. Ultra-fast yttrium hydride chemistry at high pressures via non-equilibrium states induced by x-ray free electron laser

Author

Siska, Emily, Smith, G. Alexander, Villa-Cortes, Sergio, Conway, Lewis J., Husband, Rachel J., Van Cleave, Joshua, Petitgirard, Sylvain, Cerantola, Valerio, Appel, Karen, Baehtz, Carsten, Bouffetier, Victorien, Dwiwedi, Anand, Göde, Sebastian, Gorkhover, Taisia, Konopkova, Zuzana, Hosseini, Mohammad, Kuschel, Stephan, Laurus, Torsten, Nakatsutsumi, Motoaki, Strohm, Cornelius, Sztuk-Dambietz, Jolanta, Zastrau, Ulf, Smith, Dean, Lawler, Keith V., Pickard, Chris J., Schwartz, Craig P., and Salamat, Ashkan

Subjects
Condensed Matter - Materials Science
Abstract

Controlling the formation and stoichiometric content of desired phases of materials has become a central interest for the study of a variety of fields, notably high temperature superconductivity under extreme pressures. The further possibility of accessing metastable states by initiating reactions by x-ray triggered mechanisms over ultra-short timescales is enabled with the development of x-ray free electron lasers (XFEL). Utilizing the exceptionally high brilliance x-ray pulses from the EuXFEL, we report the synthesis of a previously unobserved yttrium hydride under high pressure, along with non-stoichiometric changes in hydrogen content as probed at a repetition rate of 4.5\,MHz using time-resolved x-ray diffraction. Exploiting non-equilibrium pathways we synthesize and characterize a hydride with yttrium cations in an \textit{A}15 structure type at 125\,GPa, predicted using crystal structure searches, with a hydrogen content between 4.0--5.75 hydrogens per cation, that is enthalpically metastable on the convex hull. We demonstrate a tailored approach to changing hydrogen content using changes in x-ray fluence that is not accessible using conventional synthesis methods, and reveals a new paradigm in metastable chemical physics.

Published
2023

2. Diamond precipitation dynamics from hydrocarbons at icy planet interior conditions

Author

Frost, Mungo, McWilliams, R. Stewart, Bykova, Elena, Bykov, Maxim, Husband, Rachel J., Andriambariarijaona, Leon M., Khandarkhaeva, Saiana, Massani, Bernhard, Appel, Karen, Baehtz, Carsten, Ball, Orianna B., Cerantola, Valerio, Chariton, Stella, Choi, Jinhyuk, Cynn, Hyunchae, Duff, Matthew J., Dwivedi, Anand, Edmund, Eric, Fiquet, Guillaume, Graafsma, Heinz, Hwang, Huijeong, Jaisle, Nicolas, Kim, Jaeyong, Konôpková, Zuzana, Laurus, Torsten, Lee, Yongjae, Liermann, Hanns-Peter, McHardy, James D., McMahon, Malcolm I., Morard, Guillaume, Nakatsutsumi, Motoaki, Nguyen, Lan Anh, Ninet, Sandra, Prakapenka, Vitali B., Prescher, Clemens, Redmer, Ronald, Stern, Stephan, Strohm, Cornelius, Sztuk-Dambietz, Jolanta, Turcato, Monica, Wu, Zhongyan, Glenzer, Siegfried H., and Goncharov, Alexander F.

Published
2024
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3. Publisher Correction: Diamond precipitation dynamics from hydrocarbons at icy planet interior conditions

Author

Frost, Mungo, McWilliams, R. Stewart, Bykova, Elena, Bykov, Maxim, Husband, Rachel J., Andriambariarijaona, Leon M., Khandarkhaeva, Saiana, Massani, Bernhard, Appel, Karen, Baehtz, Carsten, Ball, Orianna B., Cerantola, Valerio, Chariton, Stella, Choi, Jinhyuk, Cynn, Hyunchae, Duff, Matthew J., Dwivedi, Anand, Edmund, Eric, Fiquet, Guillaume, Graafsma, Heinz, Hwang, Huijeong, Jaisle, Nicolas, Kim, Jaeyong, Konôpková, Zuzana, Laurus, Torsten, Lee, Yongjae, Liermann, Hanns-Peter, McHardy, James D., McMahon, Malcolm I., Morard, Guillaume, Nakatsutsumi, Motoaki, Nguyen, Lan Anh, Ninet, Sandra, Prakapenka, Vitali B., Prescher, Clemens, Redmer, Ronald, Stern, Stephan, Strohm, Cornelius, Sztuk-Dambietz, Jolanta, Turcato, Monica, Wu, Zhongyan, Glenzer, Siegfried H., and Goncharov, Alexander F.

Published
2024
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4. Megahertz single-particle imaging at the European XFEL

Author

Sobolev, Egor, Zolotarev, Serguey, Giewekemeyer, Klaus, Bielecki, Johan, Okamoto, Kenta, Reddy, Hemanth K. N., Andreasson, Jakob, Ayyer, Kartik, Barak, Imrich, Bari, Sadia, Barty, Anton, Bean, Richard, Bobkov, Sergey, Chapman, Henry N., Chojnowski, Grzegorz, Daurer, Benedikt J., Dörner, Katerina, Ekeberg, Tomas, Flückiger, Leonie, Galzitskaya, Oxana, Gelisio, Luca, Hauf, Steffen, Hogue, Brenda G., Horke, Daniel A., Hosseinizadeh, Ahmad, Ilyin, Vyacheslav, Jung, Chulho, Kim, Chan, Kim, Yoonhee, Kirian, Richard A., Kirkwood, Henry, Kulyk, Olena, Letrun, Romain, Loh, Duane, Messerschmidt, Marc, Mühlig, Kerstin, Ourmazd, Abbas, Raab, Natascha, Rode, Andrei V., Rose, Max, Round, Adam, Sato, Takushi, Schubert, Robin, Schwander, Peter, Sellberg, Jonas A., Sikorski, Marcin, Silenzi, Alessandro, Song, Changyong, Spence, John C. H., Stern, Stephan, Sztuk-Dambietz, Jolanta, Teslyuk, Anthon, Timneanu, Nicusor, Trebbin, Martin, Uetrecht, Charlotte, Weinhausen, Britta, Williams, Garth J., Xavier, P Lourdu, Xu, Chen, Vartanyants, Ivan, Lamzin, Victor, Mancuso, Adrian, and Maia, Filipe R. N. C.

Subjects
Physics - Instrumentation and Detectors, Physics - Biological Physics
Abstract

The emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimental data per day than was previously possible. The European XFEL will soon provide 27,000 pulses per second, more than two orders of magnitude more than any other XFEL. The increased pulse rate is a key enabling factor for single-particle X-ray diffractive imaging, which relies on averaging the weak diffraction signal from single biological particles. Taking full advantage of this new capability requires that all experimental steps, from sample preparation and delivery to the acquisition of diffraction patterns, are compatible with the increased pulse repetition rate. Here, we show that single-particle imaging can be performed using X-ray pulses at megahertz repetition rates. The obtained results pave the way towards exploiting high repetition-rate X-ray free-electron lasers for single-particle imaging at their full repetition rate.

Published
2019
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5. Megahertz single-particle imaging at the European XFEL

Author

Sobolev, Egor, Zolotarev, Sergei, Giewekemeyer, Klaus, Bielecki, Johan, Okamoto, Kenta, Reddy, Hemanth KN, Andreasson, Jakob, Ayyer, Kartik, Barak, Imrich, Bari, Sadia, Barty, Anton, Bean, Richard, Bobkov, Sergey, Chapman, Henry N, Chojnowski, Grzegorz, Daurer, Benedikt J, Dörner, Katerina, Ekeberg, Tomas, Flückiger, Leonie, Galzitskaya, Oxana, Gelisio, Luca, Hauf, Steffen, Hogue, Brenda G, Horke, Daniel A, Hosseinizadeh, Ahmad, Ilyin, Vyacheslav, Jung, Chulho, Kim, Chan, Kim, Yoonhee, Kirian, Richard A, Kirkwood, Henry, Kulyk, Olena, Küpper, Jochen, Letrun, Romain, Loh, N Duane, Lorenzen, Kristina, Messerschmidt, Marc, Mühlig, Kerstin, Ourmazd, Abbas, Raab, Natascha, Rode, Andrei V, Rose, Max, Round, Adam, Sato, Takushi, Schubert, Robin, Schwander, Peter, Sellberg, Jonas A, Sikorski, Marcin, Silenzi, Alessandro, Song, Changyong, Spence, John CH, Stern, Stephan, Sztuk-Dambietz, Jolanta, Teslyuk, Anthon, Timneanu, Nicusor, Trebbin, Martin, Uetrecht, Charlotte, Weinhausen, Britta, Williams, Garth J, Xavier, P Lourdu, Xu, Chen, Vartanyants, Ivan A, Lamzin, Victor S, Mancuso, Adrian, and Maia, Filipe RNC

Abstract

The emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimental data per day than was previously possible. The European XFEL is expected to provide 27,000 pulses per second, over two orders of magnitude more than any other XFEL. The increased pulse rate is a key enabling factor for single-particle X-ray diffractive imaging, which relies on averaging the weak diffraction signal from single biological particles. Taking full advantage of this new capability requires that all experimental steps, from sample preparation and delivery to the acquisition of diffraction patterns, are compatible with the increased pulse repetition rate. Here, we show that single-particle imaging can be performed using X-ray pulses at megahertz repetition rates. The results obtained pave the way towards exploiting high repetition-rate X-ray free-electron lasers for single-particle imaging at their full repetition rate.

Published
2020

6. Time-resolved serial femtosecond crystallography at the European XFEL

Author

Pandey, Suraj, Bean, Richard, Sato, Tokushi, Poudyal, Ishwor, Bielecki, Johan, Cruz Villarreal, Jorvani, Yefanov, Oleksandr, Mariani, Valerio, White, Thomas A, Kupitz, Christopher, Hunter, Mark, Abdellatif, Mohamed H, Bajt, Saša, Bondar, Valerii, Echelmeier, Austin, Doppler, Diandra, Emons, Moritz, Frank, Matthias, Fromme, Raimund, Gevorkov, Yaroslav, Giovanetti, Gabriele, Jiang, Man, Kim, Daihyun, Kim, Yoonhee, Kirkwood, Henry, Klimovskaia, Anna, Knoska, Juraj, Koua, Faisal HM, Letrun, Romain, Lisova, Stella, Maia, Luis, Mazalova, Victoria, Meza, Domingo, Michelat, Thomas, Ourmazd, Abbas, Palmer, Guido, Ramilli, Marco, Schubert, Robin, Schwander, Peter, Silenzi, Alessandro, Sztuk-Dambietz, Jolanta, Tolstikova, Alexandra, Chapman, Henry N, Ros, Alexandra, Barty, Anton, Fromme, Petra, Mancuso, Adrian P, and Schmidt, Marius

Subjects
Biochemistry and Cell Biology, Biological Sciences, Bacterial Proteins, Crystallography, X-Ray, Light, Models, Molecular, Photoreceptors, Microbial, Protein Conformation, Time Factors, Technology, Medical and Health Sciences, Developmental Biology, Biological sciences
Abstract

The European XFEL (EuXFEL) is a 3.4-km long X-ray source, which produces femtosecond, ultrabrilliant and spatially coherent X-ray pulses at megahertz (MHz) repetition rates. This X-ray source has been designed to enable the observation of ultrafast processes with near-atomic spatial resolution. Time-resolved crystallographic investigations on biological macromolecules belong to an important class of experiments that explore fundamental and functional structural displacements in these molecules. Due to the unusual MHz X-ray pulse structure at the EuXFEL, these experiments are challenging. Here, we demonstrate how a biological reaction can be followed on ultrafast timescales at the EuXFEL. We investigate the picosecond time range in the photocycle of photoactive yellow protein (PYP) with MHz X-ray pulse rates. We show that difference electron density maps of excellent quality can be obtained. The results connect the previously explored femtosecond PYP dynamics to timescales accessible at synchrotrons. This opens the door to a wide range of time-resolved studies at the EuXFEL.

Published
2020

7. Author Correction: Membrane protein megahertz crystallography at the European XFEL

Author

Gisriel, Chris, Coe, Jesse, Letrun, Romain, Yefanov, Oleksandr M, Luna-Chavez, Cesar, Stander, Natasha E, Lisova, Stella, Mariani, Valerio, Kuhn, Manuela, Aplin, Steve, Grant, Thomas D, Dörner, Katerina, Sato, Tokushi, Echelmeier, Austin, Villarreal, Jorvani Cruz, Hunter, Mark S, Wiedorn, Max O, Knoska, Juraj, Mazalova, Victoria, Roy-Chowdhury, Shatabdi, Yang, Jay-How, Jones, Alex, Bean, Richard, Bielecki, Johan, Kim, Yoonhee, Mills, Grant, Weinhausen, Britta, Meza, Jose D, Al-Qudami, Nasser, Bajt, Saša, Brehm, Gerrit, Botha, Sabine, Boukhelef, Djelloul, Brockhauser, Sandor, Bruce, Barry D, Coleman, Matthew A, Danilevski, Cyril, Discianno, Erin, Dobson, Zachary, Fangohr, Hans, Martin-Garcia, Jose M, Gevorkov, Yaroslav, Hauf, Steffen, Hosseinizadeh, Ahmad, Januschek, Friederike, Ketawala, Gihan K, Kupitz, Christopher, Maia, Luis, Manetti, Maurizio, Messerschmidt, Marc, Michelat, Thomas, Mondal, Jyotirmoy, Ourmazd, Abbas, Previtali, Gianpietro, Sarrou, Iosifina, Schön, Silvan, Schwander, Peter, Shelby, Megan L, Silenzi, Alessandro, Sztuk-Dambietz, Jolanta, Szuba, Janusz, Turcato, Monica, White, Thomas A, Wrona, Krzysztof, Xu, Chen, Abdellatif, Mohamed H, Zook, James D, Spence, John CH, Chapman, Henry N, Barty, Anton, Kirian, Richard A, Frank, Matthias, Ros, Alexandra, Schmidt, Marius, Fromme, Raimund, Mancuso, Adrian P, Fromme, Petra, and Zatsepin, Nadia A

Subjects
Biochemistry and Cell Biology, Biological Sciences
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

8. The Adaptive Gain Integrating Pixel Detector at the European XFEL

Author

Allahgholi, Aschkan, Becker, Julian, Delfs, Annette, Dinapoli, Roberto, Goettlicher, Peter, Greiffenberg, Dominic, Henrich, Beat, Hirsemann, Helmut, Kuhn, Manuela, Klanner, Robert, Klyuev, Alexander, Krueger, Hans, Lange, Sabine, Laurus, Torsten, Marras, Alessandro, Mezza, Davide, Mozzanica, Aldo, Niemann, Magdalena, Poehlsen, Jennifer, Schwandt, Joern, Sheviakov, Igor, Shi, Xintian, Smoljanin, Sergej, Steffen, Lothar, Sztuk-Dambietz, Jolanta, Trunk, Ulrich, Xia, Qingqing, Zeribi, Mourad, Zhang, Jiaguo, Zimmer, Manfred, Schmidt, Bernd, and Graafsma, Heinz

Subjects
Physics - Instrumentation and Detectors
Abstract

The Adaptive Gain Integrating Pixel Detector (AGIPD) is an x-ray imager, custom designed for the European x-ray Free-Electron Laser (XFEL). It is a fast, low noise integrating detector, with an adaptive gain amplifier per pixel. This has an equivalent noise of less than 1 keV when detecting single photons and, when switched into another gain state, a dynamic range of more than 10$^4$ photons of 12 keV. In burst mode the system is able to store 352 images while running at up to 6.5 MHz, which is compatible with the 4.5 MHz frame rate at the European XFEL. The AGIPD system was installed and commissioned in August 2017, and successfully used for the first experiments at the Single Particles, Clusters and Biomolecules (SPB) experimental station at the European XFEL since September 2017. This paper describes the principal components and performance parameters of the system., Comment: revised version after peer review

Published
2018

9. Membrane protein megahertz crystallography at the European XFEL

Author

Gisriel, Chris, Coe, Jesse, Letrun, Romain, Yefanov, Oleksandr M, Luna-Chavez, Cesar, Stander, Natasha E, Lisova, Stella, Mariani, Valerio, Kuhn, Manuela, Aplin, Steve, Grant, Thomas D, Dörner, Katerina, Sato, Tokushi, Echelmeier, Austin, Cruz Villarreal, Jorvani, Hunter, Mark S, Wiedorn, Max O, Knoska, Juraj, Mazalova, Victoria, Roy-Chowdhury, Shatabdi, Yang, Jay-How, Jones, Alex, Bean, Richard, Bielecki, Johan, Kim, Yoonhee, Mills, Grant, Weinhausen, Britta, Meza, Jose D, Al-Qudami, Nasser, Bajt, Saša, Brehm, Gerrit, Botha, Sabine, Boukhelef, Djelloul, Brockhauser, Sandor, Bruce, Barry D, Coleman, Matthew A, Danilevski, Cyril, Discianno, Erin, Dobson, Zachary, Fangohr, Hans, Martin-Garcia, Jose M, Gevorkov, Yaroslav, Hauf, Steffen, Hosseinizadeh, Ahmad, Januschek, Friederike, Ketawala, Gihan K, Kupitz, Christopher, Maia, Luis, Manetti, Maurizio, Messerschmidt, Marc, Michelat, Thomas, Mondal, Jyotirmoy, Ourmazd, Abbas, Previtali, Gianpietro, Sarrou, Iosifina, Schön, Silvan, Schwander, Peter, Shelby, Megan L, Silenzi, Alessandro, Sztuk-Dambietz, Jolanta, Szuba, Janusz, Turcato, Monica, White, Thomas A, Wrona, Krzysztof, Xu, Chen, Abdellatif, Mohamed H, Zook, James D, Spence, John CH, Chapman, Henry N, Barty, Anton, Kirian, Richard A, Frank, Matthias, Ros, Alexandra, Schmidt, Marius, Fromme, Raimund, Mancuso, Adrian P, Fromme, Petra, and Zatsepin, Nadia A

Subjects
Biochemistry and Cell Biology, Biological Sciences, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Crystallography, Cyanobacteria, Electrons, Lasers, Membrane Proteins, Models, Molecular, Photosystem I Protein Complex, Static Electricity, Synchrotrons, Thermosynechococcus, X-Rays
Abstract

The world's first superconducting megahertz repetition rate hard X-ray free-electron laser (XFEL), the European XFEL, began operation in 2017, featuring a unique pulse train structure with 886 ns between pulses. With its rapid pulse rate, the European XFEL may alleviate some of the increasing demand for XFEL beamtime, particularly for membrane protein serial femtosecond crystallography (SFX), leveraging orders-of-magnitude faster data collection. Here, we report the first membrane protein megahertz SFX experiment, where we determined a 2.9 Å-resolution SFX structure of the large membrane protein complex, Photosystem I, a > 1 MDa complex containing 36 protein subunits and 381 cofactors. We address challenges to megahertz SFX for membrane protein complexes, including growth of large quantities of crystals and the large molecular and unit cell size that influence data collection and analysis. The results imply that megahertz crystallography could have an important impact on structure determination of large protein complexes with XFELs.

Published
2019

10. A multi-million image Serial Femtosecond Crystallography dataset collected at the European XFEL

Author

Kirkwood, Henry J., de Wijn, Raphael, Mills, Grant, Letrun, Romain, Kloos, Marco, Vakili, Mohammad, Karnevskiy, Mikhail, Ahmed, Karim, Bean, Richard J., Bielecki, Johan, Dall’Antonia, Fabio, Kim, Yoonhee, Kim, Chan, Koliyadu, Jayanath, Round, Adam, Sato, Tokushi, Sikorski, Marcin, Vagovič, Patrik, Sztuk-Dambietz, Jolanta, and Mancuso, Adrian P.

Published
2022
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11. Data reduction activities at European XFEL: early results

Author

Sobolev, Egor, primary, Schmidt, Philipp, additional, Malka, Janusz, additional, Hammer, David, additional, Boukhelef, Djelloul, additional, Möller, Johannes, additional, Ahmed, Karim, additional, Bean, Richard, additional, Bermúdez Macías, Ivette Jazmín, additional, Bielecki, Johan, additional, Bösenberg, Ulrike, additional, Carinan, Cammille, additional, Dall’Antonia, Fabio, additional, Esenov, Sergey, additional, Fangohr, Hans, additional, Ferreira de Lima, Danilo Enoque, additional, Ferreira Maia, Luís Gonçalo, additional, Firoozi, Hadi, additional, Flucke, Gero, additional, Gessler, Patrick, additional, Giovanetti, Gabriele, additional, Koliyadu, Jayanath, additional, Madsen, Anders, additional, Michelat, Thomas, additional, Schuh, Michael, additional, Sikorski, Marcin, additional, Silenzi, Alessandro, additional, Sztuk-Dambietz, Jolanta, additional, Turcato, Monica, additional, Turkot, Oleksii, additional, Wrigley, James, additional, Aplin, Steve, additional, Hauf, Steffen, additional, Wrona, Krzysztof, additional, and Gelisio, Luca, additional

Published
2024
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12. Turning European XFEL raw data into user data

Author

Schmidt, Philipp, primary, Ahmed, Karim, additional, Danilevski, Cyril, additional, Hammer, David, additional, Rosca, Robert, additional, Kluyver, Thomas, additional, Michelat, Thomas, additional, Sobolev, Egor, additional, Gelisio, Luca, additional, Maia, Luis, additional, Manetti, Maurizio, additional, Malka, Janusz, additional, Wrona, Krzysztof, additional, Sztuk-Dambietz, Jolanta, additional, Rovensky, Vratko, additional, Ramilli, Marco, additional, Duarte, Nuno, additional, Lomidze, David, additional, Dourki, Ibrahym, additional, Yousef, Hazem, additional, Senfftleben, Björn, additional, Meyer, Olivier, additional, Turcato, Monica, additional, Hauf, Steffen, additional, and Aplin, Steve, additional

Published
2024
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13. Performance of an LPD prototype detector at MHz frame rates under Synchrotron and FEL radiation

Author

Koch, Andreas, Hart, Matthew, Nicholls, Tim, Angelsen, Christian, Coughlan, John, French, Marcus, Hauf, Steffen, Kuster, Markus, Sztuk-Dambietz, Jolanta, Turcato, Monica, Carini, Gabriella A., Chollet, Matthieu, Herrmann, Sven C., Lemke, Henrik T., Nelson, Silke, Song, Sanghoon, Weaver, Matt, Zhu, Diling, Meents, Alke, and Fischer, Pontus

Subjects
Physics - Instrumentation and Detectors
Abstract

A MHz frame rate X-ray area detector (LPD - Large Pixel Detector) is under development by the Rutherford Appleton Laboratory for the European XFEL. The detector will have 1 million pixels and allows analogue storage of 512 images taken at 4.5 MHz in the detector front end. The LPD detector has 500 mm thick silicon sensor tiles that are bump bonded to a readout ASIC. The ASICs preamplifier provides relatively low noise at high speed which results in a high dynamic range of 10^5 photons over an energy range of 5-20 keV. Small scale prototypes of 32x256 pixels (LPD 2-Tile detector) and 256x256 pixels (LPD supermodule detector) are now available for X-ray tests. The performance of prototypes of the detector is reported for first tests under synchrotron radiation (PETRA III at DESY) and Free-Electron-Laser radiation (LCLS at SLAC). The initial performance of the detector in terms of signal range and noise, radiation hardness and spatial and temporal response are reported. The main result is that the 4.5 MHz sampling detection chain is reliably working, including the analogue on-chip memory concept. The detector is at least radiation hard up to 5 MGy at 12 keV. In addition the multiple gain concept has been demonstrated over a dynamic range to 10^4 at 12 keV with a readout noise equivalent to <1 photon rms in its most sensitive mode.

Published
2013
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14. Status of detector development for the European XFEL

Author

Sztuk-Dambietz, Jolanta, Hauf, Steffen, Koch, Andreas, Kuster, Markus, and Turcato, Monica

Subjects
Physics - Instrumentation and Detectors
Abstract

The European X-ray Free Electron Laser (XFEL.EU) will provide as-yet-unrivaled peak brilliance and ultra-short pulses of spatially coherent X-rays with a pulse length of less than 100 fs in the energy range between 0.25 and 25 keV. The high radiation intensity and ultra-short pulse duration will open a window for novel scientific techniques and will allow to explore new phenomena in biology, chemistry, material science, as well as matter at high energy density, atomic, ion and molecular physics. The variety of scientific applications and especially the unique XFEL.EU time structure require adequate instrumentation to be developed in order to exploit the full potential of the light source. To make optimal use of the unprecedented capabilities of the European XFEL and master these vast technological challenges, the European XFEL GmbH has started a detector R&D program. The technology concepts of the detector system presently under development are complementary in their performance and will cover the requirements of a large fraction of the scientific applications envisaged for the XFEL.EU facility. The actual status of the detector development projects which includes ultra-fast 2D imaging detectors, low repetition rate 2D detectors as well as strip detectors for e.g. spectroscopy applications and the infrastructure for the detectors' calibration and tests will be presented. Furthermore, an overview of the forthcoming implementation phase of the European XFEL in terms of detector R&D will be given., Comment: Prepared for the Proccedings of SPIE Optics + Optoelectronics Conference, Prague, Czech Republic, 15th - 18th April 2013

Published
2013
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15. Detector Development for the European XFEL: Requirements and Status

Author

Koch, Andreas, Kuster, Markus, Sztuk-Dambietz, Jolanta, and Turcato, Monica

Subjects
Physics - Instrumentation and Detectors
Abstract

The variety of applications and especially the unique European XFEL time structure will require adequate instrumentation to be developed to exploit the full potential of the light source. Two-dimensional integrating X-ray detectors with ultra-fast read out up to 4.5 MHz for 1024 x 1024 pixel images are under development for a variety of imaging applications. The actual status of the European XFEL detector development projects is presented. Furthermore, an outlook will be given with respect to detector research and development, performance optimization, integration, and commissioning., Comment: Journal of Physics: Conference Series, 2012

Published
2012
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16. Operational experience with Adaptive Gain Integrating Pixel Detectors at European XFEL.

Author

Sztuk-Dambietz, Jolanta, Rovensky, Vratko, Klujev, Alexander, Laurus, Torsten, Trunk, Ulrich, Ahmed, Karim, Meyer, Olivier, Möller, Johannes, Parenti, Andrea, Raab, Natascha, Shayduk, Roman, Sikorski, Marcin, Ansaldi, Gabriele, Bösenberg, Ulrike, Luis, Lopez M., Muenich, Astrid, Preston, Thomas R., Schmidt, Philipp, Stern, Stephan, and Bean, Richard

Subjects
FREE electron lasers, PROGRAMMABLE controllers, ULTRASHORT laser pulses, DETECTORS, X-ray lasers, INFORMATION storage & retrieval systems
Abstract

The European X-ray Free Electron Laser (European XFEL) is a cutting-edge user facility that generates per second up to 27,000 ultra-short, spatially coherent X-ray pulses within an energy range of 0.26 to more than 20 keV. Specialized instrumentation, including various 2D X-ray detectors capable of handling the unique time structure of the beam, is required. The one-megapixel AGIPD (AGIPD1M) detectors, developed for the European XFEL by the AGIPD Consortium, are the primary detectors used for user experiments at the SPB/SFX and MID instruments. The first AGIPD1M detector was installed at SPB/SFX when the facility began operation in 2017, and the second one was installed at MID in November 2018. The AGIPD detector systems require a dedicated infrastructure, well-defined safety systems, and high-level control procedures to ensure stable and safe operation. As of now, the AGIPD1M detectors installed at the SPB/SFX and MID experimental end stations are fully integrated into the European XFEL environment, including mechanical integration, vacuum, power, control, data acquisition, and data processing systems. Specific high-level procedures allow facilitated detector control, and dedicated interlock systems based on Programmable Logic Controllers ensure detector safety in case of power, vacuum, or cooling failure. The first 6 years of operation have clearly demonstrated that the AGIPD1M detectors provide high-quality scientific results. The collected data, along with additional dedicated studies, have also enabled the identification and quantification of issues related to detector performance, ensuring stable operation. Characterization and calibration of detectors are among the most critical and challenging aspects of operation due to their complex nature. A methodology has been developed to enable detector characterization and data correction, both in near real-time (online) and offline mode. The calibration process optimizes detector performance and ensures the highest quality of experimental results. Overall, the experience gained from integrating and operating the AGIPD detectors at the European XFEL, along with the developed methodology for detector characterization and calibration, provides valuable insights for the development of next-generation detectors for Free Electron Laser X-ray sources. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Segmented flow generator for serial crystallography at the European X-ray free electron laser

Author

Echelmeier, Austin, Cruz Villarreal, Jorvani, Messerschmidt, Marc, Kim, Daihyun, Coe, Jesse D., Thifault, Darren, Botha, Sabine, Egatz-Gomez, Ana, Gandhi, Sahir, Brehm, Gerrit, Conrad, Chelsie E., Hansen, Debra T., Madsen, Caleb, Bajt, Saša, Meza-Aguilar, J. Domingo, Oberthür, Dominik, Wiedorn, Max O., Fleckenstein, Holger, Mendez, Derek, Knoška, Juraj, Martin-Garcia, Jose M., Hu, Hao, Lisova, Stella, Allahgholi, Aschkan, Gevorkov, Yaroslav, Ayyer, Kartik, Aplin, Steve, Ginn, Helen Mary, Graafsma, Heinz, Morgan, Andrew J., Greiffenberg, Dominic, Klujev, Alexander, Laurus, Torsten, Poehlsen, Jennifer, Trunk, Ulrich, Mezza, Davide, Schmidt, Bernd, Kuhn, Manuela, Fromme, Raimund, Sztuk-Dambietz, Jolanta, Raab, Natascha, Hauf, Steffen, Silenzi, Alessandro, Michelat, Thomas, Xu, Chen, Danilevski, Cyril, Parenti, Andrea, Mekinda, Leonce, Weinhausen, Britta, Mills, Grant, Vagovic, Patrik, Kim, Yoonhee, Kirkwood, Henry, Bean, Richard, Bielecki, Johan, Stern, Stephan, Giewekemeyer, Klaus, Round, Adam R., Schulz, Joachim, Dörner, Katerina, Grant, Thomas D., Mariani, Valerio, Barty, Anton, Mancuso, Adrian P., Weierstall, Uwe, Spence, John C. H., Chapman, Henry N., Zatsepin, Nadia, Fromme, Petra, Kirian, Richard A., and Ros, Alexandra

Published
2020
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18. A MHz X-ray diffraction set-up for dynamic compression experiments in the diamond anvil cell

Author

Husband, Rachel J., primary, Strohm, Cornelius, additional, Appel, Karen, additional, Ball, Orianna B., additional, Briggs, Richard, additional, Buchen, Johannes, additional, Cerantola, Valerio, additional, Chariton, Stella, additional, Coleman, Amy L., additional, Cynn, Hyunchae, additional, Dattelbaum, Dana, additional, Dwivedi, Anand, additional, Eggert, Jon H., additional, Ehm, Lars, additional, Evans, William J., additional, Glazyrin, Konstantin, additional, Goncharov, Alexander F., additional, Graafsma, Heinz, additional, Howard, Alex, additional, Huston, Larissa, additional, Hutchinson, Trevor M., additional, Hwang, Huijeong, additional, Jacob, Sony, additional, Kaa, Johannes, additional, Kim, Jaeyong, additional, Kim, Minseob, additional, Koemets, Egor, additional, Konôpková, Zuzana, additional, Langenhorst, Falko, additional, Laurus, Torsten, additional, Li, Xinyang, additional, Mainberger, Jona, additional, Marquardt, Hauke, additional, McBride, Emma E., additional, McGuire, Christopher, additional, McHardy, James D., additional, McMahon, Malcolm I., additional, McWilliams, R. Stewart, additional, Méndez, Alba S. J., additional, Mondal, Anshuman, additional, Morard, Guillaume, additional, O'Bannon, Earl F., additional, Otzen, Christoph, additional, Pépin, Charles M., additional, Prakapenka, Vitali B., additional, Prescher, Clemens, additional, Preston, Thomas R., additional, Redmer, Ronald, additional, Roeper, Michael, additional, Sanchez-Valle, Carmen, additional, Smith, Dean, additional, Smith, Raymond F., additional, Sneed, Daniel, additional, Speziale, Sergio, additional, Spitzbart, Tobias, additional, Stern, Stephan, additional, Sturtevant, Blake T., additional, Sztuk-Dambietz, Jolanta, additional, Talkovski, Peter, additional, Velisavljevic, Nenad, additional, Vennari, Cara, additional, Wu, Zhongyan, additional, Yoo, Choong-Shik, additional, Zastrau, Ulf, additional, Jenei, Zsolt, additional, and Liermann, Hanns-Peter, additional

Published
2023
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20. A MHz X-ray diffraction set-up for dynamic compression experiments in the diamond anvil cell

Author

Husband, Rachel J., Strohm, Cornelius, Appel, Karen, Ball, Orianna B., Briggs, Richard, Buchen, Johannes, Cerantola, Valerio, Chariton, Stella, Coleman, Amy, Cynn, Hyunchae, Dattelbaum, Dana, Dwivedi, Anand, Eggert, Jon H., Ehm, Lars, Evans, William J., Glazyrin, Konstantin, Goncharov, Alexander, Graafsma, Heinz, Howard, Alexander, Huston, Larissa, Hutchinson, Trevor M., Hwang, Huijeong, Jacob, Sony, Kaa, Johannes, Kim, Jaeyong, Kim, Minseob, Koemets, Egor, Konôpková, Zuzana, Langenhorst, Falko, Laurus, Torsten, Li, Xinyang, Mainberger, Jona, Marquardt, Hauke, McBride, Emma E., McGuire, Christopher, McHardy, James, McMahon, Malcolm I., McWilliams, R. Stewart, Méndez, Alba S. J., Mondal, Anshuman, Morard, Guillaume, O'Bannon, Earl, Otzen, Christoph, Pépin, Charles, Prakapenka, Vitali, Prescher, Clemens, Preston, Thomas, Redmer, Ronald, Roeper, Michael, Sanchez-Valle, Carmen, Smith, Dean, Smith, Raymond F., Sneed, Daniel, Speziale, Sergio, Spitzbart, Tobias, Stern, Stephan, Sturtevant, Blake, Sztuk-Dambietz, Jolanta, Talkovski, Peter, Velisavljevic, Nenad, Vennari, Cara, Wu, Zhongyan, Yoo, Choong-Shik, Zastrau, Ulf, Jenei, Zsolt, and Liermann, Hanns-Peter

Subjects
ddc:550
Abstract

Journal of synchrotron radiation 30(4), 671 - 685 (2023). doi:10.1107/S1600577523003910, An experimental platform for dynamic diamond anvil cell (dDAC) research hasbeen developed at the High Energy Density (HED) Instrument at the EuropeanX-ray Free Electron Laser (European XFEL). Advantage was taken of the highrepetition rate of the European XFEL (up to 4.5 MHz) to collect pulse-resolvedMHz X-ray diffraction data from samples as they are dynamically compressed atintermediate strain rates ( 10 3 s1), where up to 352 diffraction images can becollected from a single pulse train. The set-up employs piezo-driven dDACscapable of compressing samples in 340 ms, compatible with the maximumlength of the pulse train (550 ms). Results from rapid compression experimentson a wide range of sample systems with different X-ray scattering powers arepresented. A maximum compression rate of 87 TPa s1 was observed duringthe fast compression of Au, while a strain rate of 1100 s1 was achievedduring the rapid compression of N2 at 23 TPa s1., Published by Wiley-Blackwell, [Erscheinungsort nicht ermittelbar]

Published
2023

21. MHz data collection of a microcrystalline mixture of different jack bean proteins

Author

Grünbein, Marie Luise, Bielecki, Johan, Gorel, Alexander, Stricker, Miriam, Bean, Richard, Cammarata, Marco, Dörner, Katerina, Fröhlich, Lars, Hartmann, Elisabeth, Hauf, Steffen, Hilpert, Mario, Kim, Yoonhee, Kloos, Marco, Letrun, Romain, Messerschmidt, Marc, Mills, Grant, Nass Kovacs, Gabriela, Ramilli, Marco, Roome, Christopher M., Sato, Tokushi, Scholz, Matthias, Sliwa, Michel, Sztuk-Dambietz, Jolanta, Weik, Martin, Weinhausen, Britta, Al-Qudami, Nasser, Boukhelef, Djelloul, Brockhauser, Sandor, Ehsan, Wajid, Emons, Moritz, Esenov, Sergey, Fangohr, Hans, Kaukher, Alexander, Kluyver, Thomas, Lederer, Max, Maia, Luis, Manetti, Maurizio, Michelat, Thomas, Münnich, Astrid, Pallas, Florent, Palmer, Guido, Previtali, Gianpietro, Raab, Natascha, Silenzi, Alessandro, Szuba, Janusz, Venkatesan, Sandhya, Wrona, Krzysztof, Zhu, Jun, Doak, R. Bruce, Shoeman, Robert L., Foucar, Lutz, Colletier, Jacques-Philippe, Mancuso, Adrian P., Barends, Thomas R. M., Stan, Claudiu A., and Schlichting, Ilme

Published
2019
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22. Megahertz data collection from protein microcrystals at an X-ray free-electron laser

Author

Grünbein, Marie Luise, Bielecki, Johan, Gorel, Alexander, Stricker, Miriam, Bean, Richard, Cammarata, Marco, Dörner, Katerina, Fröhlich, Lars, Hartmann, Elisabeth, Hauf, Steffen, Hilpert, Mario, Kim, Yoonhee, Kloos, Marco, Letrun, Romain, Messerschmidt, Marc, Mills, Grant, Nass Kovacs, Gabriela, Ramilli, Marco, Roome, Christopher M., Sato, Tokushi, Scholz, Matthias, Sliwa, Michel, Sztuk-Dambietz, Jolanta, Weik, Martin, Weinhausen, Britta, Al-Qudami, Nasser, Boukhelef, Djelloul, Brockhauser, Sandor, Ehsan, Wajid, Emons, Moritz, Esenov, Sergey, Fangohr, Hans, Kaukher, Alexander, Kluyver, Thomas, Lederer, Max, Maia, Luis, Manetti, Maurizio, Michelat, Thomas, Münnich, Astrid, Pallas, Florent, Palmer, Guido, Previtali, Gianpietro, Raab, Natascha, Silenzi, Alessandro, Szuba, Janusz, Venkatesan, Sandhya, Wrona, Krzysztof, Zhu, Jun, Doak, R. Bruce, Shoeman, Robert L., Foucar, Lutz, Colletier, Jacques-Philippe, Mancuso, Adrian P., Barends, Thomas R. M., Stan, Claudiu A., and Schlichting, Ilme

Published
2018
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23. Direct Observation of the Mechanism of Antibiotic Resistance by Mix-and-Inject at the European XFEL

Author

Pandey, Suraj, Bean, Richard, Hunter, Mark, Abdellatif, Mohamed H., Bajt, Saša, Bondar, Valerii, Echelmeier, Austin, Doppler, Diandra, Emons, Moritz, Frank, Matthias, Fromme, Raimund, Gevorkov, Yaroslav, Sato, Tokushi, Giovanetti, Gabriele, Jiang, Man, Kim, Daihyun, Kim, Yoonhee, Kirkwood, Henry, Klimovskaia, Anna, Knoska, Juraj, Koua, Faisal H. M., Letrun, Romain, Lisova, Stella, Poudyal, Ishwor, Maia, Luis, Mazalova, Victoria, Meza, Domingo, Michelat, Thomas, Ourmazd, Abbas, Palmer, Guido, Ramilli, Marco, Schubert, Robin, Schwander, Peter, Silenzi, Alessandro, Bielecki, Johan, Sztuk-Dambietz, Jolanta, Tolstikova, Alexandra, Chapman, Henry N., Ros, Alexandra, Barty, Anton, Fromme, Petra, Mancuso, Adrian P., Schmidt, Marius, Cruz Villarreal, Jorvani, Yefanov, Oleksandr, Mariani, Valerio, White, Thomas A., and Kupitz, Christopher

Subjects
Enzyme substrate complex, Millisecond, Materials science, Bacterial antibiotic resistance, Chemical physics, Atomic resolution, Direct observation, Substrate (chemistry), Time resolution, ddc:610, Ultrashort pulse
Abstract

In this study, we follow the diffusion and buildup of occupancy of the substrate ceftriaxone inM. tuberculosisβ-lactamase BlaC microcrystals by structural analysis of the enzyme substrate complex at single millisecond time resolution. We also show the binding and the reaction of an inhibitor, sulbactam, on a slower millisecond time scale. We use the ‘mix-and-inject’ technique to initiate these reactions by diffusion, and determine the resulting structures by serial crystallography using ultrafast, intense X-ray pulses from the European XFEL (EuXFEL) arriving at MHz repetition rates. Here, we show how to use the EuXFEL pulse structure to dramatically increase the size of the data set and thereby the quality and time resolution of “molecular movies” which unravel ligand binding and enzymatically catalyzed reactions. This shows the great potential for the EuXFEL as a tool for biomedically relevant research, particularly, as shown here, for investigating bacterial antibiotic resistance.One Sentence SummaryDirect observation of fast ligand binding in a biomedically relevant enzyme at near atomic resolution with MHz X-ray pulses at the European XFEL.

Published
2020

24. Evaluation of serial crystallographic structure determination within megahertz pulse trains

Author

Yefanov, Oleksandr, Oberthür, Dominik, Bean, Richard, Wiedorn, Max Oliver, Knoška, Juraj, Pena, Gisel, Awel, Salah, Gumprecht, Lars, Domaracky, Martin, Sarrou, Iosifina, Xavier, Paulrajpillai Lourdu, Metz, Markus, Bajt, Saša, Mariani, Valerio, Gevorkov, Yaroslav, White, Thomas A., Tolstikova, Aleksandra, Villanueva-Perez, Pablo, Seuring, Carolin, Aplin, Steven, Estillore, Armando D., Küpper, Jochen, Klyuev, Alexander, Kuhn, Manuela, Laurus, Torsten, Graafsma, Heinz, Monteiro, Diana C.F., Trebbin, Martin, Maia, Filipe R. N. C., Cruz-Mazo, Francisco, Gañán-Calvo, Alfonso M., Heymann, Michael, Darmanin, Connie, Abbey, Brian, Schmidt, Marius, Fromme, Petra, Giewekemeyer, Klaus, Sikorski, Marcin, Graceffa, Rita, Vagovic, Patrik, Kluyver, Thomas, Bergemann, Martin, Fangohr, Hans, Sztuk-Dambietz, Jolanta, Hauf, Steffen, Raab, Natascha, Bondar, Valerii, Mancuso, Adrian P., Chapman, Henry N., Barty, Anton, Yefanov, Oleksandr, Oberthür, Dominik, Bean, Richard, Wiedorn, Max Oliver, Knoška, Juraj, Pena, Gisel, Awel, Salah, Gumprecht, Lars, Domaracky, Martin, Sarrou, Iosifina, Xavier, Paulrajpillai Lourdu, Metz, Markus, Bajt, Saša, Mariani, Valerio, Gevorkov, Yaroslav, White, Thomas A., Tolstikova, Aleksandra, Villanueva-Perez, Pablo, Seuring, Carolin, Aplin, Steven, Estillore, Armando D., Küpper, Jochen, Klyuev, Alexander, Kuhn, Manuela, Laurus, Torsten, Graafsma, Heinz, Monteiro, Diana C.F., Trebbin, Martin, Maia, Filipe R. N. C., Cruz-Mazo, Francisco, Gañán-Calvo, Alfonso M., Heymann, Michael, Darmanin, Connie, Abbey, Brian, Schmidt, Marius, Fromme, Petra, Giewekemeyer, Klaus, Sikorski, Marcin, Graceffa, Rita, Vagovic, Patrik, Kluyver, Thomas, Bergemann, Martin, Fangohr, Hans, Sztuk-Dambietz, Jolanta, Hauf, Steffen, Raab, Natascha, Bondar, Valerii, Mancuso, Adrian P., Chapman, Henry N., and Barty, Anton

Abstract

The new European X-ray Free-Electron Laser (European XFEL) is the first X-ray free-electron laser capable of delivering intense X-ray pulses with a megahertz interpulse spacing in a wavelength range suitable for atomic resolution structure determination. An outstanding but crucial question is whether the use of a pulse repetition rate nearly four orders of magnitude higher than previously possible results in unwanted structural changes due to either radiation damage or systematic effects on data quality. Here, separate structures from the first and subsequent pulses in the European XFEL pulse train were determined, showing that there is essentially no difference between structures determined from different pulses under currently available operating conditions at the European XFEL.

Published
2020

25. Shock Damage Analysis in Serial Femtosecond Crystallography Data Collected at MHz X-ray Free-Electron Lasers

Author

Gorel, Alexander, primary, Grünbein, Marie, additional, Bean, Richard, additional, Bielecki, Johan, additional, Hilpert, Mario, additional, Cascella, Michele, additional, Colletier, Jacques-Philippe, additional, Fangohr, Hans, additional, Foucar, Lutz, additional, Hartmann, Elisabeth, additional, Hunter, Mark, additional, Kirkwood, Henry, additional, Kloos, Marco, additional, Letrun, Romain, additional, Michelat, Thomas, additional, Shoeman, Robert, additional, Sztuk-Dambietz, Jolanta, additional, Tetreau, Guillaume, additional, Zimmermann, Herbert, additional, Mancuso, Adrian, additional, Barends, Thomas, additional, Doak, R., additional, Stan, Claudiu, additional, and Schlichting, Ilme, additional

Published
2020
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26. Time-resolved serial femtosecond crystallography at the European XFEL

Author

Pandey, Suraj, primary, Bean, Richard, additional, Sato, Tokushi, additional, Poudyal, Ishwor, additional, Bielecki, Johan, additional, Cruz Villarreal, Jorvani, additional, Yefanov, Oleksandr, additional, Mariani, Valerio, additional, White, Thomas A., additional, Kupitz, Christopher, additional, Hunter, Mark, additional, Abdellatif, Mohamed H., additional, Bajt, Saša, additional, Bondar, Valerii, additional, Echelmeier, Austin, additional, Doppler, Diandra, additional, Emons, Moritz, additional, Frank, Matthias, additional, Fromme, Raimund, additional, Gevorkov, Yaroslav, additional, Giovanetti, Gabriele, additional, Jiang, Man, additional, Kim, Daihyun, additional, Kim, Yoonhee, additional, Kirkwood, Henry, additional, Klimovskaia, Anna, additional, Knoska, Juraj, additional, Koua, Faisal H. M., additional, Letrun, Romain, additional, Lisova, Stella, additional, Maia, Luis, additional, Mazalova, Victoria, additional, Meza, Domingo, additional, Michelat, Thomas, additional, Ourmazd, Abbas, additional, Palmer, Guido, additional, Ramilli, Marco, additional, Schubert, Robin, additional, Schwander, Peter, additional, Silenzi, Alessandro, additional, Sztuk-Dambietz, Jolanta, additional, Tolstikova, Alexandra, additional, Chapman, Henry N., additional, Ros, Alexandra, additional, Barty, Anton, additional, Fromme, Petra, additional, Mancuso, Adrian P., additional, and Schmidt, Marius, additional

Published
2019
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27. Evaluation of serial crystallographic structure determination within megahertz pulse trains

Author

Yefanov, Oleksandr, primary, Oberthür, Dominik, additional, Bean, Richard, additional, Wiedorn, Max O., additional, Knoska, Juraj, additional, Pena, Gisel, additional, Awel, Salah, additional, Gumprecht, Lars, additional, Domaracky, Martin, additional, Sarrou, Iosifina, additional, Lourdu Xavier, P., additional, Metz, Markus, additional, Bajt, Saša, additional, Mariani, Valerio, additional, Gevorkov, Yaroslav, additional, White, Thomas A., additional, Tolstikova, Aleksandra, additional, Villanueva-Perez, Pablo, additional, Seuring, Carolin, additional, Aplin, Steve, additional, Estillore, Armando D., additional, Küpper, Jochen, additional, Klyuev, Alexander, additional, Kuhn, Manuela, additional, Laurus, Torsten, additional, Graafsma, Heinz, additional, Monteiro, Diana C. F., additional, Trebbin, Martin, additional, Maia, Filipe R. N. C., additional, Cruz-Mazo, Francisco, additional, Gañán-Calvo, Alfonso M., additional, Heymann, Michael, additional, Darmanin, Connie, additional, Abbey, Brian, additional, Schmidt, Marius, additional, Fromme, Petra, additional, Giewekemeyer, Klaus, additional, Sikorski, Marcin, additional, Graceffa, Rita, additional, Vagovic, Patrik, additional, Kluyver, Thomas, additional, Bergemann, Martin, additional, Fangohr, Hans, additional, Sztuk-Dambietz, Jolanta, additional, Hauf, Steffen, additional, Raab, Natascha, additional, Bondar, Valerii, additional, Mancuso, Adrian P., additional, Chapman, Henry, additional, and Barty, Anton, additional

Published
2019
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28. Evaluation of serial crystallographic structure determination within megahertz pulse trains

Author

Yefanov, Oleksandr, Oberth��r, Dominik, Bean, Richard, Wiedorn, Max Oliver, Kno��ka, Juraj, Pena, Gisel, Awel, Salah, Gumprecht, Lars, Domaracky, Martin, Sarrou, Iosifina, Xavier, Paulrajpillai Lourdu, Metz, Markus, Bajt, Sa��a, Mariani, Valerio, Gevorkov, Yaroslav, White, Thomas A., Tolstikova, Aleksandra, Villanueva-Perez, Pablo, Seuring, Carolin, Aplin, Steven, Estillore, Armando D., K��pper, Jochen, Klyuev, Alexander, Kuhn, Manuela, Laurus, Torsten, Graafsma, Heinz, Monteiro, Diana C.F., Trebbin, Martin, Maia, Filipe R. N. C., Cruz-Mazo, Francisco, Ga����n-Calvo, Alfonso M., Heymann, Michael, Darmanin, Connie, Abbey, Brian, Schmidt, Marius, Fromme, Petra, Giewekemeyer, Klaus, Sikorski, Marcin, Graceffa, Rita, Vagovic, Patrik, Kluyver, Thomas, Bergemann, Martin, Fangohr, Hans, Sztuk-Dambietz, Jolanta, Hauf, Steffen, Raab, Natascha, Bondar, Valerii, Mancuso, Adrian P., Chapman, Henry N., and Barty, Anton

Subjects
Fysikalisk kemi, ARTICLES, lcsh:QD901-999, 004: Informatik, Acceleratorfysik och instrumentering, lcsh:Crystallography, ddc:500, Biological Systems, ddc:004, Informatik [004], Accelerator Physics and Instrumentation, Physical Chemistry
Abstract

Structural dynamics 6(6), 064702 - (2019). doi:10.1063/1.5124387, Published by AIP Publishing LLC, Melville, NY

Published
2019
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29. The Adaptive Gain Integrating Pixel Detector at the European XFEL

Author

Allahgholi, Aschkan, Becker, Julian, Delfs, Annette, Dinapoli, Roberto, Goettlicher, Peter, Greiffenberg, Dominic, Henrich, Beat, Hirsemann, Helmut, Kuhn, Manuela, Klanner, Robert, Klyuev, Alexander, Krueger, Hans, Lange, Sabine, Laurus, Torsten, Marras, Alessandro, Mezza, Davide, Mozzanica, Aldo, Niemann, Magdalena, Poehlsen, Jennifer, Schwandt, Joern, Sheviakov, Igor, Shi, Xintian, Smoljanin, Sergej, Steffen, Lothar, Sztuk-Dambietz, Jolanta, Trunk, Ulrich, Xia, Qingqing, Zeribi, Mourad, Zhang, Jiaguo, Zimmer, Manfred, Schmitt, Bernd, and Graafsma, Heinz

Subjects
X-ray detector, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, European XFEL, Acceleratorfysik och instrumentering, Instrumentation and Detectors (physics.ins-det), Accelerator Physics and Instrumentation, Research Papers, AGIPD, ddc:550, Physics::Accelerator Physics, Radiologi och bildbehandling, Radiology, Nuclear Medicine and Medical Imaging
Abstract

Journal of synchrotron radiation 26(1), 74 - 82 (2019). doi:10.1107/S1600577518016077, The Adaptive Gain Integrating Pixel Detector (AGIPD) is an X-ray imager, custom designed for the European X-ray Free-Electron Laser (XFEL). It is a fast, low-noise integrating detector, with an adaptive gain amplifier per pixel. This has an equivalent noise of less than 1 keV when detecting single photons and, when switched into another gain state, a dynamic range of more than 10$^4$ photons of 12 keV. In burst mode the system is able to store 352 images while running at up to 6.5 MHz, which is compatible with the 4.5 MHz frame rate at the European XFEL. The AGIPD system was installed and commissioned in August 2017, and successfully used for the first experiments at the Single Particles, Clusters and Biomolecules (SPB) experimental station at the European XFEL since September 2017. This paper describes the principal components and performance parameters of the system., Published by Wiley-Blackwell, Chester

Published
2019

30. Membrane protein megahertz crystallography at the European XFEL

Author

Gisriel, Christopher, Coe, Jesse, Letrun, Romain, Yefanov, Oleksandr, Luna-Chavez, Cesar, Stander, Natasha E., Lisova, Stella, Mariani, Valerio, Kuhn, Manuela, Aplin, Steven, Grant, Thomas D., Dörner, Katerina Henrike, Sato, Tokushi, Echelmeier, Austin, Cruz Villarreal, Jorvani, Hunter, Mark S., Wiedorn, Max Oliver, Knoška, Juraj, Mazalova, Victoria, Roy-Chowdhury, Shatabdi, Yang, Jay How, Jones, Alex, Bean, Richard, Bielecki, Johan, Kim, Yoonhee, Mills, Grant, Weinhausen, Britta, Meza, Jose D., Al-Qudami, Nasser, Bajt, Saša, Brehm, Gerrit, Botha, Sabine, Boukhelef, Djelloul, Brockhauser, Sandor, Bruce, Barry D., Coleman, Matthew A., Danilevski, Cyril, Discianno, Erin, Dobson, Zachary, Fangohr, Hans, Martin-Garcia, Jose Manuel, Gevorkov, Yaroslav, Hauf, Steffen, Hosseinizadeh, Ahmad, Januschek, F., Ketawala, Gihan K., Kupitz, Christopher, Maia, Luis, Manetti, Maurizio, Messerschmidt, Marc, Michelat, Thomas, Mondal, Jyotirmoy, Ourmazd, Abbas, Previtali, Gianpietro, Sarrou, Iosifina, Schön, Silvan, Schwander, Peter, Shelby, Megan L., Silenzi, Alessandro, Sztuk-Dambietz, Jolanta, Szuba, Janusz, Turcato, Monica, White, Thomas A., Wrona, Krzysztof, Xu, Chen, Abdellatif, Mohamed H., Zook, James D., Spence, John C. H., Chapman, Henry N., Barty, Anton, Kirian, Richard A., Frank, Matthias, Ros, Alexandra, Schmidt, Marius, Fromme, Raimund, Mancuso, Adrian P., Fromme, Petra, Zatsepin, Nadia, Gisriel, Christopher, Coe, Jesse, Letrun, Romain, Yefanov, Oleksandr, Luna-Chavez, Cesar, Stander, Natasha E., Lisova, Stella, Mariani, Valerio, Kuhn, Manuela, Aplin, Steven, Grant, Thomas D., Dörner, Katerina Henrike, Sato, Tokushi, Echelmeier, Austin, Cruz Villarreal, Jorvani, Hunter, Mark S., Wiedorn, Max Oliver, Knoška, Juraj, Mazalova, Victoria, Roy-Chowdhury, Shatabdi, Yang, Jay How, Jones, Alex, Bean, Richard, Bielecki, Johan, Kim, Yoonhee, Mills, Grant, Weinhausen, Britta, Meza, Jose D., Al-Qudami, Nasser, Bajt, Saša, Brehm, Gerrit, Botha, Sabine, Boukhelef, Djelloul, Brockhauser, Sandor, Bruce, Barry D., Coleman, Matthew A., Danilevski, Cyril, Discianno, Erin, Dobson, Zachary, Fangohr, Hans, Martin-Garcia, Jose Manuel, Gevorkov, Yaroslav, Hauf, Steffen, Hosseinizadeh, Ahmad, Januschek, F., Ketawala, Gihan K., Kupitz, Christopher, Maia, Luis, Manetti, Maurizio, Messerschmidt, Marc, Michelat, Thomas, Mondal, Jyotirmoy, Ourmazd, Abbas, Previtali, Gianpietro, Sarrou, Iosifina, Schön, Silvan, Schwander, Peter, Shelby, Megan L., Silenzi, Alessandro, Sztuk-Dambietz, Jolanta, Szuba, Janusz, Turcato, Monica, White, Thomas A., Wrona, Krzysztof, Xu, Chen, Abdellatif, Mohamed H., Zook, James D., Spence, John C. H., Chapman, Henry N., Barty, Anton, Kirian, Richard A., Frank, Matthias, Ros, Alexandra, Schmidt, Marius, Fromme, Raimund, Mancuso, Adrian P., Fromme, Petra, and Zatsepin, Nadia

Abstract

The world’s first superconducting megahertz repetition rate hard X-ray free-electron laser (XFEL), the European XFEL, began operation in 2017, featuring a unique pulse train structure with 886 ns between pulses. With its rapid pulse rate, the European XFEL may alleviate some of the increasing demand for XFEL beamtime, particularly for membrane protein serial femtosecond crystallography (SFX), leveraging orders-of-magnitude faster data collection. Here, we report the first membrane protein megahertz SFX experiment, where we determined a 2.9 Å-resolution SFX structure of the large membrane protein complex, Photosystem I, a > 1 MDa complex containing 36 protein subunits and 381 cofactors. We address challenges to megahertz SFX for membrane protein complexes, including growth of large quantities of crystals and the large molecular and unit cell size that influence data collection and analysis. The results imply that megahertz crystallography could have an important impact on structure determination of large protein complexes with XFELs.

Published
2019

31. Data Analysis Support in Karabo at European XFEL

Author

Fangohr, Hans, Aplin, Steve, Barty, Anton, Beg, Marijan, Bondar, Valerii, Boukhelef, Djelloul, Brockhauser, Sandor, Danilevski, Cyril, Ehsan, Wajid, Esenov, Sergey, Flucke, Gero, Giovanetti, Gabriele, Goeries, Dennis, Hauf, Steffen, Heisen, Burkhard, Hickin, David, Khakhulin, Dmitry, Klimovskaia, Anna, Kluyver, Thomas, Kuhn, Manuela, Kuster, Markus, Lang, Philipp-Michael, Maia, Luis, Mariani, Valerio, Mekinda, Leonce, Michelat, Thomas, Parenti, Andrea, Previtali, Gianpietro, Santos, Hugo, Silenzi, Alessandro, Sztuk-Dambietz, Jolanta, Szuba, Janusz, Teichmann, Martin, Weger, Kerstin, Wiggins, John, Wrona, Krzysztof, and Xu, Chen

Subjects
Data Analytics, Accelerator Physics
Abstract

We describe the data analysis structure that is integrated into the Karabo framework [1] to support scientific experiments and data analysis at European XFEL GmbH. The photon science experiments have a range of data analysis requirements, including online (i.e. near real-time during the actual measurement) and offline data analysis. The Karabo data analysis framework supports execution of automatic data analysis for routine tasks, supports complex experiment protocols including data analysis feedback integration to instrument control, and supports integration of external applications. The online data analysis is carried out using distributed and accelerator hardware (such as GPUs) where required to balance load and achieve near real-time data analysis throughput. Analysis routines provided by Karabo are implemented in C++ and Python, and make use of established scientific libraries. The XFEL control and analysis software team collaborates with users to integrate experiment specific analysis codes, protocols and requirements into this framework, and to make it available for the experiments and subsequent offline data analysis., Proceedings of the 16th Int. Conf. on Accelerator and Large Experimental Control Systems, ICALEPCS2017, Barcelona, Spain

Published
2018
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32. The Adaptive Gain Integrating Pixel Detector at the European XFEL

Author

Allahgholi, Aschkan, primary, Becker, Julian, additional, Delfs, Annette, additional, Dinapoli, Roberto, additional, Goettlicher, Peter, additional, Greiffenberg, Dominic, additional, Henrich, Beat, additional, Hirsemann, Helmut, additional, Kuhn, Manuela, additional, Klanner, Robert, additional, Klyuev, Alexander, additional, Krueger, Hans, additional, Lange, Sabine, additional, Laurus, Torsten, additional, Marras, Alessandro, additional, Mezza, Davide, additional, Mozzanica, Aldo, additional, Niemann, Magdalena, additional, Poehlsen, Jennifer, additional, Schwandt, Joern, additional, Sheviakov, Igor, additional, Shi, Xintian, additional, Smoljanin, Sergej, additional, Steffen, Lothar, additional, Sztuk-Dambietz, Jolanta, additional, Trunk, Ulrich, additional, Xia, Qingqing, additional, Zeribi, Mourad, additional, Zhang, Jiaguo, additional, Zimmer, Manfred, additional, Schmitt, Bernd, additional, and Graafsma, Heinz, additional

Published
2019
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33. Megahertz serial crystallography

Author

Wiedorn, Max Oliver, Oberthür, Dominik, Bean, Richard, Schubert, Robin, Werner, Nadine, Abbey, Brian, Aepfelbacher, Martin, Adriano, Luigi, Allahgholi, Aschkan, Al-Qudami, Nasser, Andreasson, Jakob, Shelby, Megan L., Shoemann, Robert L., Sikorski, Marcin, Silenzi, Alessandro, Stan, Claudiu A., Shi, Xintian, Stern, Stephan, Sztuk-Dambietz, Jolanta, Szuba, Janusz, Tolstikova, Aleksandra, Aplin, Steven, Trebbin, Martin, Trunk, Ulrich, Vagovic, Patrik, Ve, Thomas, Weinhausen, Britta, White, Thomas A., Wrona, Krzysztof, Xu, Chen, Yefanov, Oleksandr, Zatsepin, Nadia, Awel, Salah, Zhang, Jiaguo, Perbandt, Markus, Mancuso, Adrian P., Betzel, Christian, Chapman, Henry N., Banty, Anton, Ayyer, Kartik, Bajt, Saša, Barák, Imrich, Bari, Sadia, Bielecki, Johan, Botha, Sabine, Boukhelef, Djelloul, Brehm, Wolfgang, Brockhauser, Sandor, Cheviakov, Igor, Coleman, Matthew A., Cruz-Mazo, Francisco, Danilevski, Cyril, Darmanin, Connie, Doak, R. Bruce, Domaracky, Martin, Dörner, Katerina Henrike, Du, Yang, Fangohr, Hans, Fleckenstein, Holger, Frank, Matthias, Fromme, Petra, Gañán-Calvo, Alfonso M., Gevorkov, Yaroslav, Giewekemeyer, Klaus, Ginn, Helen Mary, Graafsma, Heinz, Graceffa, Rita, Greiffenberg, Dominic, Gumprecht, Lars, Göttlicher, Peter, Hajdu, János, Hauf, Steffen, Heymann, Michael, Holmes, Susannah, Horke, Daniel A., Hunter, Mark S., Imlau, Siegfried, Kaukher, Alexander, Kim, Yoonhee, Klyuev, Alexander, Knoška, Juraj, Kobe, Bostjan, Kuhn, Manuela, Kupitz, Christopher, Küpper, Jochen, Lahey-Rudolph, Janine Mia, Laurus, Torsten, Le Cong, Karoline, Letrun, Romain, Xavier, Paulrajpillai Lourdu, Maia, Luis, Maia, Filipe R. N. C., Mariani, Valerio, Messerschmidt, Marc, Metz, Markus, Mezza, Davide, Michelat, Thomas, Mills, Grant, Monteiro, Diana C.F., Morgan, Andrew J., Mühlig, Kerstin, Munke, Anna, Münnich, Astrid, Nette, Julia, Nugent, Keith A., Nuguid, Theresa, Orville, Allen M., Pandey, Suraj, Pena, Gisel, Vilanueva-Pérez, Pablo, Pöhlsen, Jennifer, Previtali, Gianpietro, Redecke, Lars, Riekehr, Winnie Maria, Rohde, Holger, Round, Adam R., Safenreiter, Tatiana, Sarrou, Iosifina, Sato, Tokushi, Schmidt, Marius, Schmitt, Bernd, Schönherr, Robert, Schulz, Joachim, Sellberg, Jonas Alexander, Seibert, M. Marvin, Seuring, Carolin, Wiedorn, Max Oliver, Oberthür, Dominik, Bean, Richard, Schubert, Robin, Werner, Nadine, Abbey, Brian, Aepfelbacher, Martin, Adriano, Luigi, Allahgholi, Aschkan, Al-Qudami, Nasser, Andreasson, Jakob, Shelby, Megan L., Shoemann, Robert L., Sikorski, Marcin, Silenzi, Alessandro, Stan, Claudiu A., Shi, Xintian, Stern, Stephan, Sztuk-Dambietz, Jolanta, Szuba, Janusz, Tolstikova, Aleksandra, Aplin, Steven, Trebbin, Martin, Trunk, Ulrich, Vagovic, Patrik, Ve, Thomas, Weinhausen, Britta, White, Thomas A., Wrona, Krzysztof, Xu, Chen, Yefanov, Oleksandr, Zatsepin, Nadia, Awel, Salah, Zhang, Jiaguo, Perbandt, Markus, Mancuso, Adrian P., Betzel, Christian, Chapman, Henry N., Banty, Anton, Ayyer, Kartik, Bajt, Saša, Barák, Imrich, Bari, Sadia, Bielecki, Johan, Botha, Sabine, Boukhelef, Djelloul, Brehm, Wolfgang, Brockhauser, Sandor, Cheviakov, Igor, Coleman, Matthew A., Cruz-Mazo, Francisco, Danilevski, Cyril, Darmanin, Connie, Doak, R. Bruce, Domaracky, Martin, Dörner, Katerina Henrike, Du, Yang, Fangohr, Hans, Fleckenstein, Holger, Frank, Matthias, Fromme, Petra, Gañán-Calvo, Alfonso M., Gevorkov, Yaroslav, Giewekemeyer, Klaus, Ginn, Helen Mary, Graafsma, Heinz, Graceffa, Rita, Greiffenberg, Dominic, Gumprecht, Lars, Göttlicher, Peter, Hajdu, János, Hauf, Steffen, Heymann, Michael, Holmes, Susannah, Horke, Daniel A., Hunter, Mark S., Imlau, Siegfried, Kaukher, Alexander, Kim, Yoonhee, Klyuev, Alexander, Knoška, Juraj, Kobe, Bostjan, Kuhn, Manuela, Kupitz, Christopher, Küpper, Jochen, Lahey-Rudolph, Janine Mia, Laurus, Torsten, Le Cong, Karoline, Letrun, Romain, Xavier, Paulrajpillai Lourdu, Maia, Luis, Maia, Filipe R. N. C., Mariani, Valerio, Messerschmidt, Marc, Metz, Markus, Mezza, Davide, Michelat, Thomas, Mills, Grant, Monteiro, Diana C.F., Morgan, Andrew J., Mühlig, Kerstin, Munke, Anna, Münnich, Astrid, Nette, Julia, Nugent, Keith A., Nuguid, Theresa, Orville, Allen M., Pandey, Suraj, Pena, Gisel, Vilanueva-Pérez, Pablo, Pöhlsen, Jennifer, Previtali, Gianpietro, Redecke, Lars, Riekehr, Winnie Maria, Rohde, Holger, Round, Adam R., Safenreiter, Tatiana, Sarrou, Iosifina, Sato, Tokushi, Schmidt, Marius, Schmitt, Bernd, Schönherr, Robert, Schulz, Joachim, Sellberg, Jonas Alexander, Seibert, M. Marvin, and Seuring, Carolin

Abstract

The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a β-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.

Published
2018

34. Calibration and Calibration Data Processing Concepts at the European XFEL

Author

Hauf, Steffen, Boukhelef, Djelloul, Weidenspointner, Georg, Youngman, Christopher, Gessler, Patrick, Heisen, Burkhard, Kuster, Markus, Maia, Luis, Raab, Natascha, Sztuk-Dambietz, Jolanta, Turcato, Monica, and Wrona, Krzysztof

Abstract

The European X-ray Free Electron Laser (Altarelli, 2006) is a high-intensity X-ray light source currently being constructed in Hamburg, Germany, that will provide spatially coherent X-rays in the energy range between 0.25 keV and 25 keV. The machine will deliver a unique time structure, consisting of up to 2700 pulses, with a 4.5 MHz repetition rate, 10 times per second at very high photon fluxes up to 1017 photons/s (Tschentscher, 2012). The LPD (Hart, 2012; Koch, 2013), DSSC (Porro, 2010, 2012; Lutz, 2010) and AGIPD (Graafsma, 2009) detectors are being developed to provide Mpixel imaging capabilities at the aforementioned repetition rates for a dynamic range spanning from single photon sensitivity to 104 –105 photons per pixel. The detectors are optimized for specific energy ranges. A direct consequence of the aforementioned detectors’ characteristics is that they generate raw data volumes unprecedented in photon science, ranging up to 1Mpixel x 640 memory cells x 10 pulse/s x 16 bit, i.e. 12.8 Gbyte/s. On-detector vetoing may not necessarily lower these rates much - a memory cell freed by a vetoed pulse may be used by data from one of the remaining 2700 pulses a train consists of. The PC-layer may reduce this data amount by additional software triggering, but this is not guaranteed. Figure 1 gives an overview of the different data products at European XFEL, as well as their flows and involved user roles, under the assumption that processing takes place within XFEL’s Karabo framework (Heisen, 2013). In addition to the high data rates, the Mpixel detectors’ on-sensor memory-cell and multi-gain-stage architectures necessary for the high dynamic range, pose unique challenges in detector-specific data corrections and calibration (Weidenspointner, 2012; Sztuk-Dambietz, 2013a). These challenges are addressed by providing a dedicated and thoroughly characterized set of test stands, which utilize continuous sources (Fe-55, X-ray tubes) as well as a pulsed setup: PulXar (Sztuk-Dambietz, 2013b), which is designed to produce X-ray pulses of 50-150 ns duration, within a 0.6 ms burst followed by a 99.4 ms gap. The radiation it produces thus closely matches the XFEL pulse structure. Additionally, simulation tools are being developed to assist in detector characterization (Bohlen and Joy, 2013).

Published
2014

37. Scaled momentum distributions for K S 0 and ∧/∧ in DIS at HERA

Author

Abramowicz, Halina, Abt, Iris, Adamczyk, Leszek, Adamus, Marek, Aggarwal, Ritu, Antonelli, Stefano, Antonioli, Pietro, Antonov, Alexei A., Arneodo, Michele, Aushev, Volodymyr E., Aushev, Y., Bachynska, O., Bamberger, Andreas, Barakbaev, A. N., Barbagli, G., Bári, Gergely, Barreiro, Fernando, Bartosik, N., Bartsch, D., Basile, Maurizio, Behnke, Olaf, Behr, Jörg, Behrens, Ulf, Bellagamba, Lorenzo, Bertolin, Alessandro, Bhadra, Sampa, Bindi, Marcello, Blohm, C., Bokhonov, V., Bołd, Tomasz, Bondarenko, K., Boos, E. G., Borras, Kerstin, Boscherini, Davide, Bot, D., Brock, Ian C., Brownson, Eric, Brugnera, Riccardo, Brümmer, Nichol C., Bruni, Alessia, Bruni, Graziano, Brzozowska, Beata, Bussey, Peter J., Bylsma, B. G., Caldwell, Allen C., Capua, M., Carlin, Roberto, Catterall, C. D., Chekanov, S. V., Chwastowski, Janusz J., Ciborowski, Jacek, Ciesielski, Robert, Cifarelli, Luisa, Cindolo, Federico, Contin, Andrea, Cooper-Sarkar, Amanda M., Coppola, Nicola, Corradi, Massimo, Corriveau, François, Costa, Mario J., D'Agostini, Giulio, Dal Corso, Flavio, Del Peso, J., Dementiev, R. K., De Pasquale, Salvatore, Derrick, Mark, Devenish, Robin C E, Dobur, Didar, Dolgoshein, Boris A., Dolinska, Ganna, Doyle, Anthony T., Drugakov, V., Durkin, Louis S., Dusini, S., Eisenberg, Yehuda, Ermolov., P. F., Eskreys, A. W., Fang, Shuangshi, Fazio, Salvatore, Ferrando, James, Ferrero, Mauro I., Figiel, Jan, Forrest, Matthew, Foster, Brian, Gach, Grzegorz P., Galas, Anna I., Gallo, Elisabetta, Garfagnini, Alberto, Geiser, Achim, Gialas, Ioannis, Gladilin, Leonid K., Gladkov, Daniil, Glasman, Claudia J., Gogota, O., Golubkov, Yu A., Göttlicher, Peter, Grabowska-Bo, I., Grebenyuk, Julia, Gregor, Ingrid Maria, Grigorescu, Gabriela, Grzelak, Grzegorz, Gueta, O., Guzik, M., Gwenlan, Claire, Haas, Tobias, Hain, W., Hamatsu, Ryosuke, Hart, John C., Hartmann, Hans Jörg, Hartner, G., Hilger, Erwin, Hochman, Don, Hori, R., Horton, K., Hüttmann, Antje, Ibrahim, Zainol Abidin, Iga, Yasunobu, Ingbir, Ronen, Ishitsuka, Masaki, Jakob, H. P., Januschek, Friederike, Jones, T. W., Jüngst, M., Kadenko, Igor M., Kahle, Benjamin, Kananov, S., Kanno, Takayuki, Karshon, Uri, Karstens, Falk, Katkov, Igor I., Kaur, Manjit, Kaur, Prabhdeep, Keramidas, Avraam A., Khein, Lev A., Kim, Jihyun, Kisielewska, Danuta, Kitamura, Shoichi, Klanner, Robert, Klein, Uta, Koffeman, Els N., Kooijman, Paul M., Korol, Korzhavina, Irina A., Kotański, A., Kötz, Ulrich, Kowalski, Henryk, Kuprash, Oleg E., Kuze, Masahiro, Lee, Albert, Levchenko, Boris B., Levy, Aharon, Libov, Vladyslav, Limentani, Sylvia, Ling, T. Y., Lisovyi, Mykhailo, Łobodzińska, Ewelina Maria, Lohmann, Wolfgang, Löhr, Bernd, Lohrmann, Erich, Long, Kenneth, Longhin, Andrea, Lontkovskyi, Denys I., Lukina, Ou Yu, Maeda, Jouji, Magill, Stephen R., Makarenko, Irina V., Malka, Janusz, Mankel, Rainer, Margotti, Anselmo, Marini, Giuseppe P., Martin, John F., Mastroberardino, A., Mattingly, M. C K, Melzer-Pellmann, Isabell Alissandra, Mergelmeyer, Sebastian, Miglioranzi, Silvia, Mohamad Idris, F., Monaco, Vincenzo, Montanari, Andrea, Morris, John D., Mujkic, Kenan, Musgrave, B., Nagano, Kunihiro, Namsoo, Tim A., Nania, Rosario, Nigro, Andrea, Ning, Y., Nobe, Takuya, Noor, U., Notz, Dieter, Nowak, Roman J., Nuncio-Quiroz, A. E., Oh, B. Y., Okazaki, Noriaki, Oliver, Katie, Olkiewicz, Krystyna, Onishchuk, Yu M., Papageorgiu, K., Parenti, Andrea, Paul, Ewald, Pawlak, J. M., Pawlik, Barbara, Pelfer, Pier Giovanni, Pellegrino, Antonio R., Perlański, Wojciech, Perrey, Hanno, Piotrzkowski, Krzysztof, Pluciński, Pawel, Pokrovskiy, N. S., Polini, Alessandro, Proskuryakov, Alexander S., Przybycień, Mariusz B., Raval, Amita, Reeder, D. D., Reisert, Burkard, Ren, Zhongliang, Repond, José, Ri, Y. D., Robertson, Ashley I., Roloff, Philipp, Rubinsky, I. A., Ruspa, Marta, Sacchi, Roberto, Salii, Andrii, Samson, Ursula, Sartorelli, Gabriella, Savin, Alexander A., Saxon, David H., Schioppa, Marco, Schlenstedt, Stefan, Schleper, Peter, Schmidke, William B., Schneekloth, U., Schönberg, Verena, Schörner-Sadenius, Thomas, Schwartz, Joshua David, Sciulli, Frank J., Shcheglova, Lydia M., Shehzadi, R., Shimizu, Shima, Singh, Inderpal J., Skillicorn, Ian O., Słomiński, Wojciech, Smith, Wesley H., Sola, Valentina, Solano, Ada, Son, Dongchul, Sosnovtsev, V. V., Spiridonov, A., Stadie, Hartmut, Stanco, Luca, Stern, Amir, Stewart, T. P., Stifutkin, A. A., Stopa, P., Suchkov, S. I., Susinno, G. C., Suszycki, Leszek, Sztuk-Dambietz, Jolanta, Szuba, Dorota, Szuba, J., Tapper, A. D., Tassi, Enrico, Terrón, Juan M., Theedt, T., Tiecke., H. G J M, Tokushuku, Katsuo, Tomalak, O., Tomaszewska, Justyna, Tsurugai, Takashi, Turcato, Monica, Tymieniecka, Teresa, Vázquez., Manuel M., Verbytskyi, Andrii, Viazlo, O., Vlasov, Nikolai N., Volynets, G. V., Walczak, Roman, Wan Abdullah, Wan Ahmad Tajuddin Bin, Whitmore, J. J., Wiggers, Lisbeth W., Wing, Matthew, Własenko, Michał, Wolf, Günter K., Wolfe, H., Wrona, K., Yagües-Molina, A. G., Yamada, Satoru, Yamazaki, Yasunori, Yoshida, Rik, Youngman, Christopher, Zarnecki, Aleksander Filip, Zawiejski, Leszek, Zenaiev, Oleksandr, Zeuner, Wolfram D., Zhautykov, B. O., Zhmak, N., Zhou, C., Zichichi, Antonino, Zolkapli, Zukhaimira, Zolko, M., Zotkin, D. S., and UAM. Departamento de Física Teórica

Subjects
Lepton-nucleon scattering, High Energy Physics::Phenomenology, Física, High Energy Physics::Experiment, Nuclear Experiment
Abstract

Journal of High Energy Physics 2012. 3 (2012): 020 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA), Scaled momentum distributions for the strange hadrons KS0 and Λ/Λ were measured in deep inelastic ep scattering with the ZEUS detector at HERA using an integrated luminosity of 330 pb-1. The evolution of these distribuitions with the photon virtuality, Q2, was studied in the kinematic region 10 < Q2 < 40000 GeV2 and 0.001 < x < 0.75, where x is the Bjorken scaling variable. Clear scaling violations are observed. Predictions based on different approaches to fragmentation were compared to the measurements. Leading-logarithm parton-shower Monte Carlo calculations interfaced to the Lund string fragmentation model describe the data reasonably well in the whole range measured. Next- to-leading-order QCD calculations based on fragmentation functions, FFs, extracted from e+e- data alone, fail to describe the measurements. The calculations based on FFs extracted from a global analysis including e+e-, ep and pp data give an improved description. The measurements presented in this paper have the potential to further constrain the FFs of quarks, anti-quarks and gluons yielding KS 0 and Λ/ Λ̄ strange hadrons., We thank the DESY Directorate for their strong support and encouragement. The remarkable achievements of the HERA machine group were essential for the successful completion of this work and are greatly appreciated. We are grateful for the support of the DESY computing and network services

Published
2012

42. Megahertz serial crystallography

Author

Wiedorn, Max Oliver, Oberth��r, Dominik, Bean, Richard, Schubert, Robin, Werner, Nadine, Abbey, Brian, Aepfelbacher, Martin, Adriano, Luigi, Allahgholi, Aschkan, Al-Qudami, Nasser, Andreasson, Jakob, Horke, Daniel A., Hunter, Mark S., Imlau, Siegfried, Kaukher, Alexander, Kim, Yoonhee, Klyuev, Alexander, Kno��ka, Juraj, Kobe, Bostjan, Kuhn, Manuela, Kupitz, Christopher, M��hlig, Kerstin, K��pper, Jochen, Lahey-Rudolph, Janine Mia, Laurus, Torsten, Le Cong, Karoline, Letrun, Romain, Xavier, Paulrajpillai Lourdu, Maia, Luis, Maia, Filipe R. N. C., Mariani, Valerio, Messerschmidt, Marc, Munke, Anna, Metz, Markus, Mezza, Davide, Michelat, Thomas, Mills, Grant, Monteiro, Diana C.F., Morgan, Andrew J., M��nnich, Astrid, Nette, Julia, Nugent, Keith A., Nuguid, Theresa, Orville, Allen M., Pandey, Suraj, Pena, Gisel, Villanueva-Perez, Pablo, Shelby, Megan L., P��hlsen, Jennifer, Previtali, Gianpietro, Redecke, Lars, Riekehr, Winnie Maria, Rohde, Holger, Round, Adam R., Safenreiter, Tatiana, Sarrou, Iosifina, Sato, Tokushi, Schmidt, Marius, Shoemann, Robert L., Schmitt, Bernd, Sch��nherr, Robert, Schulz, Joachim, Sellberg, Jonas Alexander, Seibert, M. Marvin, Seuring, Carolin, Sikorski, Marcin, Silenzi, Alessandro, Stan, Claudiu A., Shi, Xintian, Stern, Stephan, Sztuk-Dambietz, Jolanta, Szuba, Janusz, Tolstikova, Aleksandra, Aplin, Steven, Trebbin, Martin, Trunk, Ulrich, Vagovic, Patrik, Ve, Thomas, Weinhausen, Britta, White, Thomas A., Wrona, Krzysztof, Xu, Chen, Yefanov, Oleksandr, Zatsepin, Nadia, Awel, Salah, Zhang, Jiaguo, Perbandt, Markus, Mancuso, Adrian P., Betzel, Christian, Chapman, Henry N., Banty, Anton, Ayyer, Kartik, Bajt, Sa��a, Bar��k, Imrich, Bari, Sadia, Bielecki, Johan, Botha, Sabine, Boukhelef, Djelloul, Brehm, Wolfgang, Brockhauser, Sandor, Cheviakov, Igor, Coleman, Matthew A., Cruz-Mazo, Francisco, Danilevski, Cyril, Darmanin, Connie, Doak, R. Bruce, Domaracky, Martin, D��rner, Katerina Henrike, Du, Yang, Fangohr, Hans, Fleckenstein, Holger, Frank, Matthias, Fromme, Petra, Ga����n-Calvo, Alfonso M., Gevorkov, Yaroslav, Giewekemeyer, Klaus, Ginn, Helen Mary, Graafsma, Heinz, Graceffa, Rita, Greiffenberg, Dominic, Gumprecht, Lars, G��ttlicher, Peter, Hajdu, J��nos, Hauf, Steffen, Heymann, Michael, and Holmes, Susannah

Subjects
600: Technik, 3. Good health
Abstract

The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a ��-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.

43. Ultrafast Yttrium Hydride Chemistry at High Pressures via Non-equilibrium States Induced by an X-ray Free Electron Laser.

Author

Siska E, Smith GA, Villa-Cortes S, Conway LJ, Husband RJ, Van Cleave J, Petitgirard S, Cerantola V, Appel K, Baehtz C, Bouffetier V, Dwivedi A, Göde S, Gorkhover T, Konopkova Z, Hosseini-Saber SMA, Kuschel S, Laurus T, Nakatsutsumi M, Strohm C, Sztuk-Dambietz J, Zastrau U, Smith D, Lawler KV, Pickard CJ, Schwartz CP, and Salamat A

Abstract

Controlling the formation and stoichiometric content of the desired phases of materials has become of central interest for a variety of fields. The possibility of accessing metastable states by initiating reactions by X-ray-triggered mechanisms over ultrashort time scales has been enabled by the development of X-ray free electron lasers (XFELs). Utilizing the exceptionally high-brilliance X-ray pulses from the EuXFEL, we report the synthesis of a previously unobserved yttrium hydride under high pressure, along with nonstoichiometric changes in hydrogen content as probed at a repetition rate of 4.5 MHz using time-resolved X-ray diffraction. Exploiting non-equilibrium pathways, we synthesize and characterize a hydride in a Weaire-Phelan structure type at pressures as low as 125 GPa, predicted using a crystal structure search, with a hydrogen content of 4.0-5.75 hydrogens per cation, that is enthalpically metastable on the convex hull.

Published
2024
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