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29 results on '"Sztretye, Mónika"'

3. Genetic Manipulation of CB1 Cannabinoid Receptors Reveals a Role in Maintaining Proper Skeletal Muscle Morphology and Function in Mice

Author

Singlár, Zoltán, primary, Ganbat, Nyamkhuu, additional, Szentesi, Péter, additional, Osgonsandag, Nomin, additional, Szabó, László, additional, Telek, Andrea, additional, Fodor, János, additional, Dienes, Beatrix, additional, Gönczi, Mónika, additional, Csernoch, László, additional, and Sztretye, Mónika, additional

Published
2022
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4. Astaxanthin Exerts Anabolic Effects via Pleiotropic Modulation of the Excitable Tissue

Author

Gönczi, Mónika, primary, Csemer, Andrea, additional, Szabó, László, additional, Sztretye, Mónika, additional, Fodor, János, additional, Pocsai, Krisztina, additional, Szenthe, Kálmán, additional, Keller-Pintér, Anikó, additional, Köhler, Zoltán Márton, additional, Nánási, Péter, additional, Szentandrássy, Norbert, additional, Pál, Balázs, additional, and Csernoch, László, additional

Published
2022
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5. Assessing the potential of nutraceuticals as geroprotectors on muscle performance and cognition in aging mice

Author

Singlár, Zoltán, Szentesi, Péter, Fodor, János, Angyal, Ágnes, Csernoch, László, and Sztretye, Mónika

Subjects
cognition, calcium homeostasis, Supplementary Figure 1, S1, S2 video, krill oil, aging, excitation–contraction coupling, excitation-contraction coupling, RM1-950, Article, astaxanthin, mitochondrial calcium, Therapeutics. Pharmacology, nutraceutical, skeletal muscle, muscle performance
Abstract

Aging and frailty are associated with a decline in muscle force generation, which is a direct consequence of reduced muscle quantity and quality. Among the leading contributors to aging is the generation of reactive oxygen species, the byproducts of terminal oxidation. Their negative effects can be moderated via antioxidant supplementation. Krill oil and astaxanthin (AX) are nutraceuticals with a variety of health promoting, geroprotective, anti-inflammatory, anti-diabetic and anti-fatigue effects. In this work, we examined the functional effects of these two nutraceutical agents supplemented via pelleted chow in aging mice by examining in vivo and in vitro skeletal muscle function, along with aspects of intracellular and mitochondrial calcium homeostasis, as well as cognition and spatial memory. AX diet regimen limited weight gain compared to the control group, however, this phenomenon was not accompanied by muscle tissue mass decline. On the other hand, both AX and krill oil supplementation increased force production without altering calcium homeostasis during excitation-contraction coupling mechanism or mitochondrial calcium uptake processes. We also provide evidence of improved spatial memory and learning ability in aging mice because of krill oil supplementation. Taken together, our data favors the application of antioxidant nutraceuticals as geroprotectors to improve cognition and healthy aging by virtue of improved skeletal muscle force production.

Published
2021
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14. Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging

Author

Sztretye, Mónika, Dienes, Beatrix, Gönczi, Mónika, Czirják, Tamás, Csernoch, László, Dux, László, Szentesi, Péter, and Keller-Pintér, Anikó

Subjects
Article Subject
Abstract

Oxidative stress is characterized by an imbalance between prooxidant and antioxidant species, leading to macromolecular damage and disruption of redox signaling and cellular control. It is a hallmark of various diseases including metabolic syndrome, chronic fatigue syndrome, neurodegenerative, cardiovascular, inflammatory, and age-related diseases. Several mitochondrial defects have been considered to contribute to the development of oxidative stress and known as the major mediators of the aging process and subsequent age-associated diseases. Thus, mitochondrial-targeted antioxidants should prevent or slow down these processes and prolong longevity. This is the reason why antioxidant treatments are extensively studied and newer and newer compounds with such an effect appear. Astaxanthin, a xanthophyll carotenoid, is the most abundant carotenoid in marine organisms and is one of the most powerful natural compounds with remarkable antioxidant activity. Here, we summarize its antioxidant targets, effects, and benefits in diseases and with aging.

Published
2019
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26. Charged Surface Area of Maurocalcine Determines Its Interaction with the Skeletal Ryanodine Receptor

Author

Lukács, Balázs, primary, Sztretye, Mónika, additional, Almássy, János, additional, Sárközi, Sándor, additional, Dienes, Beatrix, additional, Mabrouk, Kamel, additional, Simut, Cecilia, additional, Szabó, László, additional, Szentesi, Péter, additional, De Waard, Michel, additional, Ronjat, Michel, additional, Jóna, István, additional, and Csernoch, László, additional

Published
2008
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27. Measurement of RyR Permeability Reveals a Role of Calsequestrin in Termination of SR \(Ca^{2+}\) Release in Skeletal Muscle

Author

Sztretye, Monika, Yi, Jianxun, Figueroa, Lourdes, Zhou, Jingsong, Royer, Leandro, Brum, Gustavo, Ríos, Eduardo, and Allen, Paul Denney

Abstract

The mechanisms that terminate \(Ca^{2+}\) release from the sarcoplasmic reticulum are not fully understood. D4cpv-Casq1 (Sztretye et al. 2011. J. Gen. Physiol. doi:10.1085/jgp.201010591) was used in mouse skeletal muscle cells under voltage clamp to measure free \(Ca^{2+}\) concentration inside the sarcoplasmic reticulum (SR), \([Ca^{2+}]_{SR}\), simultaneously with that in the cytosol, \([Ca^{2+}]_c\), during the response to long-lasting depolarization of the plasma membrane. The ratio of \(Ca^{2+}\) release flux (derived from \([Ca^{2+}]_c(t)\)) over the gradient that drives it (essentially equal to \([Ca^{2+}]_{SR}\)) provided directly, for the first time, a dynamic measure of the permeability to \(Ca^{2+}\) of the releasing SR membrane. During maximal depolarization, flux rapidly rises to a peak and then decays. Before 0.5 s, \([Ca^{2+}]_{SR}\) stabilized at ~35% of its resting level; depletion was therefore incomplete. By 0.4 s of depolarization, the measured permeability decayed to ~10% of maximum, indicating ryanodine receptor channel closure. Inactivation of the t tubule voltage sensor was immeasurably small by this time and thus not a significant factor in channel closure. In cells of mice null for Casq1, permeability did not decrease in the same way, indicating that calsequestrin (Casq) is essential in the mechanism of channel closure and termination of \(Ca^{2+}\) release. The absence of this mechanism explains why the total amount of calcium releasable by depolarization is not greatly reduced in Casq-null muscle (Royer et al. 2010. J. Gen. Physiol. doi:10.1085/jgp.201010454). When the fast buffer BAPTA was introduced in the cytosol, release flux became more intense, and the SR emptied earlier. The consequent reduction in permeability accelerated as well, reaching comparable decay at earlier times but comparable levels of depletion. This observation indicates that \([Ca^{2+}]_{SR}\), sensed by Casq and transmitted to the channels presumably via connecting proteins, is determinant to cause the closure that terminates \(Ca^{2+}\) release.

Published
2011
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28. Improved Tetanic Force and Mitochondrial Calcium Homeostasis by Astaxanthin Treatment in Mouse Skeletal Muscle.

Author

Sztretye, Mónika, Singlár, Zoltán, Szabó, László, Angyal, Ágnes, Balogh, Norbert, Vakilzadeh, Faranak, Szentesi, Péter, Dienes, Beatrix, and Csernoch, László

Subjects
ASTAXANTHIN, HOMEOSTASIS, CALCIUM, INTRACELLULAR calcium, LIPID metabolism, CALCIUM metabolism, SKELETAL muscle physiology
Abstract

Background: Astaxanthin (AX) a marine carotenoid is a powerful natural antioxidant which protects against oxidative stress and improves muscle performance. Retinol and its derivatives were described to affect lipid and energy metabolism. Up to date, the effects of AX and retinol on excitation-contraction coupling (ECC) in skeletal muscle are poorly described. Methods: 18 C57Bl6 mice were divided into two groups: Control and AX supplemented in rodent chow for 4 weeks (AstaReal A1010). In vivo and in vitro force and intracellular calcium homeostasis was studied. In some experiments acute treatment with retinol was employed. Results: The voltage activation of calcium transients (V50) were investigated in single flexor digitorum brevis isolated fibers under patch clamp and no significant changes were found following AX supplementation. Retinol shifted V50 towards more positive values and decreased the peak F/F0 of the calcium transients. The amplitude of tetani in the extensor digitorum longus was significantly higher in AX than in control group. Lastly, the mitochondrial calcium uptake was found to be less prominent in AX. Conclusion: AX supplementation increases in vitro tetanic force without affecting ECC and exerts a protecting effect on the mitochondria. Retinol treatment has an inhibitory effect on ECC in skeletal muscle. [ABSTRACT FROM AUTHOR]

Published
2020
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